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Anne McArdle

Professor Anne McArdle
BSc (Hons.) PhD, FAPS

Contact

Mdcr02@liverpool.ac.uk

+44 (0)151 794 9059

Research



Research grants

Close regulation of peroxiredoxin oxidation is essential for maintenance of muscle mass and function in the elderly.

MEDICAL RESEARCH COUNCIL

December 2021 - March 2025

Microgravity as a model for accelerated skeletal muscle ageing

UK SPACE AGENCY (UK)

November 2018 - May 2022

HDHL- Combining vitamin E-functionalized chocolate with physical exercise to reduce the risk of protein-energy malnutrition in aged people (CHOKO-AGE)

UK RESEARCH AND INNOVATION

April 2021 - April 2025

Determining the mechanism responsible for frailty in older people: opportunities for novel interventions.

THE TERESA ROSENBAUM GOLDEN CHARITABLE TRUST (THE ROSETREES TRUST) (UK)

October 2016 - September 2019

Neuromuscular redox homeostasis in mice lacking SOD1 and aging wild type mice

NATIONAL INSTITUTES OF HEALTH (USA)

September 2016 - April 2022

The Royal Canin Wellness Clinic for Senior Cats - An initiative to promote the health of older cats

ROYAL CANIN (FRANCE)

January 2016 - September 2028

Microgravity as a model for accelerated skeletal muscle ageing

UK SPACE AGENCY (UK)

October 2017 - April 2018

Characterisation of the skeletal muscle secretome in IIM

THE MYOSITIS ASSOCIATION (TMA) (USA)

October 2015 - July 2019

Resident senescent cells drive the ageing phenotype of skeletal muscle

BRITISH SOCIETY FOR RESEARCH ON AGEING (UK)

September 2015 - October 2019

Disruption of redox relays in the age-related failure of muscle responses to contractile activity

MEDICAL RESEARCH COUNCIL

March 2017 - September 2021

201551427 Mrs Batool Ali M Alghamdi

ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

February 2022 - January 2026

Development of the UK study for the ESA FLUMIAS project: Mitochondrial hydrogen peroxide as a mediator of muscle loss under microgravity and ageing

UK SPACE AGENCY (UK)

July 2022 - December 2027

Liverpool array tomography: revitalising and strengthening the capabilities of a national hub for biomedical volume EM research (Liverpool AT: vEM)

MEDICAL RESEARCH COUNCIL

July 2024 - March 2025

MicroAge II: Mitochondria as Key Regulators of Muscle Mass in Microgravity and during Ageing the Funded Activities

UK SPACE AGENCY (UK)

February 2023 - March 2026

Mitochondrial hydrogen peroxide as the mediator of skeletal muscle loss under microgravity and during ageing on earth

UK SPACE AGENCY (UK)

October 2021 - September 2022

Denervation of small numbers of fibres during ageing leads to dysregulation of ROS and functional changes in whole skeletal muscles

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

April 2013 - March 2016

Dietary polyphenols as modulators of redox signalling pathways to reduce chronio inflammation in the elderly

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

April 2011 - January 2015

Centre of Excellence in musculoskeletal ageing research (MRC CIMA)

MEDICAL RESEARCH COUNCIL

June 2012 - December 2017

Translational research into Frailty for the benefit of Older People

THE DOWAGER COUNTESS ELEANOR PEEL TRUST (UK)

February 2009 - April 2012

Molecular mechanisms of preservation of muscle with age by HSP70.

EUROPEAN COMMISSION

August 2002 - July 2004

Extracellular Reactive Oxygen Species as Propagators of Tissue Ageing.

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

July 2002 - February 2006

Insulin resistance mediates age-related loss of muscle mass and function

RESEARCH INTO AGEING

February 2007 - February 2010

Pilot Study to investigate the role of glutamine in the early protective stress response.

INTENSIVE CARE SOCIETY (UK)

July 2006 - July 2009

Role of defective mitochondrial function in the loss of skeletal muscle and weakness that occurs in patients with chronic renal failure

MERSEY KIDNEY FIRST (UK)

June 2011 - November 2013

Capacity building award in integrative mammalian biology

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

January 2007 - October 2015

Modulation of aberrant mitochondrial and cytokine production in muscles of patients with CFS by polyphenols

MEDICAL RESEARCH COUNCIL, THE ME ASSOCIATION (UK)

September 2012 - April 2016

Free radical generation by skeletal muscle: signals for adaptation to contractile activity?

WELLCOME TRUST (UK)

February 2001 - February 2004

The role of heat shock proteins in ageing-related loss of muscle function.

RESEARCH INTO AGEING

April 1998 - April 2001

Examination of the effect of antioxidant supplementation on the ability of cells from the elderly to respond to stress.

ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

August 2001 - July 2002

The role of heat shock proteins in glutamine-induced protection of skeletal muscle during sepsis.

MEDICAL RESEARCH COUNCIL

September 2005 - December 2008

The role of Heat Shock Factor activation in the age related failure of regeneration in skeletal muscles of old mice.

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

October 2006 - September 2009

Ageing-Related Skeletal Muscle Weakness: Mechanisms of Prevention by Stress Proteins.

RESEARCH INTO AGEING

October 2001 - September 2006

Are reactive oxygen species a mediator of skeletal muscle damage and weakness in IIM?

THE MYOSITIS ASSOCIATION (TMA) (USA)

January 2015 - December 2020

Motor unit remodelling contributes to the age-related loss of skeletal muscle fibres

MEDICAL RESEARCH COUNCIL

June 2015 - June 2018