Research outputs
2026
Spatial transcriptomics uncovers the hybrid molecular identity, ciliated phenotype, and immune signature of adenomyosis lesions
Maclean, A., Johnson, E., Rushworth, C., Hill, C. J., Gutierrez, E. C., & Hapangama, D. K. (2026). Spatial transcriptomics uncovers the hybrid molecular identity, ciliated phenotype, and immune signature of adenomyosis lesions. SCIENCE ADVANCES, 12(26), 16 pages. doi:10.1126/sciadv.aea6379
Hydrosalpinx perturbs the tubal and endometrial immune environment
Aljassim, F., Rigby, C. H., Drury, J. A., Alnafakh, R., Rushworth, C., Maclean, A., . . . Hill, C. J. (2026). Hydrosalpinx perturbs the tubal and endometrial immune environment. REPRODUCTION AND FERTILITY, 7(2), 8 pages. doi:10.1530/RAF-25-0204
2025
Patient preferences for non-invasive diagnostic biospecimens among women with chronic pelvic pain: A cross-sectional survey
Wyatt, J., Powell, S. G., Arshad, I., Hill, C. J., Maclean, A., Probert, C., . . . Hapangama, D. K. (2025). Patient preferences for non-invasive diagnostic biospecimens among women with chronic pelvic pain: A cross-sectional survey. Journal of Endometriosis and Uterine Disorders, 11. doi:10.1016/j.jeud.2025.100121
Spatial Transcriptomics Identifies Immune Cell Dysregulation in Adenomyosis, Endometriosis, and Fibroids, and Potential for Re-Purposed Treatments
Maclean, A., Johnson, E., Gutierrez, E. C., & Hapangama, D. K. (2025). Spatial Transcriptomics Identifies Immune Cell Dysregulation in Adenomyosis, Endometriosis, and Fibroids, and Potential for Re-Purposed Treatments. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 132 (pp. 4). Retrieved from https://www.webofscience.com/
Transcriptional Profiling of SSEA-1<SUP>+</SUP> Endometrial Epithelial Progenitor Cells Highlights Their Role in Endometrial Regeneration, Remodeling, and Homeostasis
Al-Lamee, H., Soul, J., Green, D., Drury, J., Hill, C. J., Vasieva, O., . . . Hapangama, D. K. (2025). Transcriptional Profiling of SSEA-1<SUP>+</SUP> Endometrial Epithelial Progenitor Cells Highlights Their Role in Endometrial Regeneration, Remodeling, and Homeostasis. FASEB JOURNAL, 39(9), 20 pages. doi:10.1096/fj.202402861R
Spatial Transcriptomics Identifies Immune Cell Dysregulation in Adenomyosis, Endometriosis, and Fibroids
Maclean, A., Johnson, E., Caamano-Gutierrez, E., & Hapangama, D. K. (2025). Spatial Transcriptomics Identifies Immune Cell Dysregulation in Adenomyosis, Endometriosis, and Fibroids. In REPRODUCTIVE SCIENCES Vol. 32 (pp. 53A). Retrieved from https://www.webofscience.com/
Hormone receptor profile of ectopic and eutopic endometrium in adenomyosis: a systematic review
Maclean, A., Tipple, L., Newton, E., & Hapangama, D. K. (2025). Hormone receptor profile of ectopic and eutopic endometrium in adenomyosis: a systematic review. Human Reproduction Open. doi:10.1093/hropen/hoaf002
Hormonal Control of the Fallopian Tube
Dutton, P. J., Maclean, A. J., Aljassim, F., Badran, D., McKinley, A., Bunni, E., . . . Hapangama, D. K. (2025). Hormonal Control of the Fallopian Tube. In Fallopian Tube Physiology and Clinical Aspects (pp. 106-131). doi:10.1142/9789811263965_0006
2024
Spatial transcriptomics identifies dysregulated pathways within endometrium of adenomyosis, endometriosis and fibroids
Badran, D., Maclean, A., Johnson, E., Gutierrez, E. C., & Hapangama, D. (2024). Spatial transcriptomics identifies dysregulated pathways within endometrium of adenomyosis, endometriosis and fibroids. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 131 (pp. 50-51). Retrieved from https://www.webofscience.com/
Supplement: Abstracts of the RCOG World Congress 2024, 15 - 17 October 2024, Muscat, Oman.
Supplement: Abstracts of the RCOG World Congress 2024, 15 - 17 October 2024, Muscat, Oman. (2024). BJOG : an international journal of obstetrics and gynaecology, 131(Suppl 5), 3-214. doi:10.1111/1471-0528.17946
Identification of key transcriptional and functional differences in adenomyosis lesions to identify novel therapeutic targets
Maclean, A. (2024). Identification of key transcriptional and functional differences in adenomyosis lesions to identify novel therapeutic targets. (University of Liverpool).
P-283 Spatial transcriptomics identifies dysregulated pathways in adenomyosis proposing potential re-purposed lesion-specific treatments
Maclean, A., Johnson, E., Caamano-Gutierrez, E., & Hapangama, D. K. (2024). P-283 Spatial transcriptomics identifies dysregulated pathways in adenomyosis proposing potential re-purposed lesion-specific treatments. Human Reproduction, 39(Supplement_1), deae108.651. doi:10.1093/humrep/deae108.651
P-312 Transcriptional profiling of SSEA-1+ endometrial epithelial cells highlights their role in endometrial regeneration, remodelling and homeostasis
Al-Lamee, H., Soul, J., Green, D., Drury, J., Hill, C., Valentijn, A., . . . Hapangama, D. (2024). P-312 Transcriptional profiling of SSEA-1+ endometrial epithelial cells highlights their role in endometrial regeneration, remodelling and homeostasis. Human Reproduction, 39(Supplement_1), deae108.677. doi:10.1093/humrep/deae108.677
P-312 Transcriptional profiling of SSEA-I plus endometrial epithelial cells highlights their role in endometrial regeneration, remodelling and homeostasis
Al-Lamee, H., Soul, J., Green, D., Drury, J., Hill, C., Valentijn, A., . . . Hapangama, D. (2024). P-312 Transcriptional profiling of SSEA-I plus endometrial epithelial cells highlights their role in endometrial regeneration, remodelling and homeostasis. In HUMAN REPRODUCTION Vol. 39 (pp. I341-+). Retrieved from https://www.webofscience.com/
Spatial transcriptomics identifies dysregulated pathways in adenomyosis proposing potential re-purposed lesion-specific treatments
Maclean, A., Johnson, E., Caamano-Gutierrez, E., & Hapangama, D. K. (2024). Spatial transcriptomics identifies dysregulated pathways in adenomyosis proposing potential re-purposed lesion-specific treatments. In HUMAN REPRODUCTION Vol. 39 (pp. I328). Retrieved from https://www.webofscience.com/
Diagnostic utility of clinicodemographic, biochemical and metabolite variables to identify viable pregnancies in a symptomatic cohort during early gestation.
Hill, C. J., Phelan, M. M., Dutton, P. J., Busuulwa, P., Maclean, A., Davison, A. S., . . . Hapangama, D. K. (2024). Diagnostic utility of clinicodemographic, biochemical and metabolite variables to identify viable pregnancies in a symptomatic cohort during early gestation.. Scientific reports, 14(1), 11172. doi:10.1038/s41598-024-61690-3
Spatial Profiling of Adenomyosis Lesions Reveals Region Specific Transcriptional Differences Compared to the Eutopic Endometrium.
Maclean, A., Emily, J., Gutierrez, E. C., & Hapangama, D. K. (2024). Spatial Profiling of Adenomyosis Lesions Reveals Region Specific Transcriptional Differences Compared to the Eutopic Endometrium.. In REPRODUCTIVE SCIENCES Vol. 31 (pp. 124A). Retrieved from https://www.webofscience.com/
2023
Characterising the immune cell phenotype of ectopic adenomyosis lesions compared with eutopic endometrium: A systematic review
Maclean, A., Barzilova, V., Patel, S., Bates, F., & Hapangama, D. K. (2023). Characterising the immune cell phenotype of ectopic adenomyosis lesions compared with eutopic endometrium: A systematic review. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 157, 10 pages. doi:10.1016/j.jri.2023.103925
Characterising the Immune Cell Phenotype in Adenomyosis and Application to a New Physiomimetic 3D Model
Maclean, A., Barzilova, V., Bates, F., Hill, C., & Hapangama, D. K. (2023). Characterising the Immune Cell Phenotype in Adenomyosis and Application to a New Physiomimetic 3D Model. In REPRODUCTIVE SCIENCES Vol. 30 (pp. 202A-203A). Retrieved from https://www.webofscience.com/
Organ-on-a-Chip Models of the Uterine Wall
Hill, C. J., Busch, C., Maclean, A., Hapangama, D. K., Zagnoni, M., & Sandison, M. E. (2023). Organ-on-a-Chip Models of the Uterine Wall. In REPRODUCTIVE SCIENCES Vol. 30 (pp. 199A). Retrieved from https://www.webofscience.com/
Phenotypical Changes in the Myometrium of Adenomyosis Uteri: A Systematic Review
Hapangama, N., Choi, F., Maclean, A., & Hapangama, D. K. (2023). Phenotypical Changes in the Myometrium of Adenomyosis Uteri: A Systematic Review. In REPRODUCTIVE SCIENCES Vol. 30 (pp. 201A). Retrieved from https://www.webofscience.com/
2022
Characterisation of novel in-vitro 3D cell-culture model of adenomyosis
Maclean, A., Hill, C., & Hapangama, D. (2022). Characterisation of novel in-vitro 3D cell-culture model of adenomyosis. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 129 (pp. 9). Retrieved from https://www.webofscience.com/
The effect of pre-analytical variables on downstream application and data analysis of human endometrial biopsies
Maclean, A., Adishesh, M., Button, L., Richards, L., Alnafakh, R., Newton, E., . . . Hapangama, D. K. (2022). The effect of pre-analytical variables on downstream application and data analysis of human endometrial biopsies. HUMAN REPRODUCTION OPEN, 2022(3), 11 pages. doi:10.1093/hropen/hoac026
Characterisation of Novel <i>In Vitro</i> 3D Cell Culture Model of Adenomyosis
Maclean, A., Hill, C. J., & Hapangama, D. K. (2022). Characterisation of Novel <i>In Vitro</i> 3D Cell Culture Model of Adenomyosis. In REPRODUCTIVE SCIENCES Vol. 29 (pp. 69). Retrieved from https://www.webofscience.com/
Novel microarchitecture of human endometrial glands: implications in endometrial regeneration and pathologies
Tempest, N., Hill, C. J., Maclean, A., Marston, K., Powell, S. G., Al-Lamee, H., & Hapangama, D. K. (2022). Novel microarchitecture of human endometrial glands: implications in endometrial regeneration and pathologies. HUMAN REPRODUCTION UPDATE, 28(2), 153-171. doi:10.1093/humupd/dmab039
2021
A systematic review and meta-analysis of gestational diabetes mellitus and mental health among BAME populations
Delanerolle, G., Phiri, P., Zeng, Y., Marston, K., Tempest, N., Busuulwa, P., . . . Hapangama, D. K. (2021). A systematic review and meta-analysis of gestational diabetes mellitus and mental health among BAME populations. ECLINICALMEDICINE, 38, 24 pages. doi:10.1016/j.eclinm.2021.101016
An exploration of the mental health sequelae of fibroids amongst BAME women
Thomas, E., Delanerolle, G., Phan, T., Zeng, Y., Shi, J., Phiri, P., . . . Hapangama, D. (2021). An exploration of the mental health sequelae of fibroids amongst BAME women. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 128 (pp. 222). Retrieved from https://www.webofscience.com/
Exploring the mental health sequelae of pre-eclampsia amongst BAME women
Duffy, G., Delanerolle, G., Hapangama, D., Zeng, Y., Shi, J., Phiri, P., . . . Tempest, N. (2021). Exploring the mental health sequelae of pre-eclampsia amongst BAME women. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 128 (pp. 119-120). Retrieved from https://www.webofscience.com/
Systematic review of gestational diabetes and mental health sequelae amongst BAME women
Marston, K., Delanerolle, G., Phan, T., Zeng, Y., Shi, J., Phiri, P., . . . Hapangama, D. (2021). Systematic review of gestational diabetes and mental health sequelae amongst BAME women. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 128 (pp. 119). Retrieved from https://www.webofscience.com/
A Systematic Review and Meta-Analysis of Gestational Diabetes and Mental Health Among BAME Populations
Delanerolle, G., Phiri, P., Zeng, Y., Tempest, N., Masterson, K., Busuulwa, P., . . . Hapangama, D. K. (2021). A Systematic Review and Meta-Analysis of Gestational Diabetes and Mental Health Among BAME Populations. doi:10.2139/ssrn.3825536
2020
Developing a Preoperative Algorithm for the Diagnosis of Uterine Leiomyosarcoma
Lawlor, H., Ward, A., Maclean, A., Lane, S., Adishesh, M., Taylor, S., . . . Hapangama, D. K. (2020). Developing a Preoperative Algorithm for the Diagnosis of Uterine Leiomyosarcoma. DIAGNOSTICS, 10(10). doi:10.3390/diagnostics10100735
Fallopian tube epithelial cells express androgen receptor and have a distinct hormonal responsiveness when compared with endometrial epithelium
Maclean, A., Bunni, E., Makrydima, S., Withington, A., Kamal, A. M., Valentijn, A. J., & Hapangama, D. K. (2020). Fallopian tube epithelial cells express androgen receptor and have a distinct hormonal responsiveness when compared with endometrial epithelium. HUMAN REPRODUCTION, 35(9), 2097-2106. doi:10.1093/humrep/deaa177
Endometriosis and the Fallopian Tubes: Theories of Origin and Clinical Implications
Hill, C. J., Fakhreldin, M., Maclean, A., Dobson, L., Nancarrow, L., Bradfield, A., . . . Hapangama, D. K. (2020). Endometriosis and the Fallopian Tubes: Theories of Origin and Clinical Implications. JOURNAL OF CLINICAL MEDICINE, 9(6), 21 pages. doi:10.3390/jcm9061905
Human Uterine Biopsy: Research Value and Common Pitfalls.
Maclean, A., Kamal, A., Adishesh, M., Alnafakh, R., Tempest, N., & Hapangama, D. K. (2020). Human Uterine Biopsy: Research Value and Common Pitfalls.. International Journal of Reproductive Medicine, 2020, 9275360. doi:10.1155/2020/9275360
Hormone Interactions in Endometrial Cancer
Kamal, A., Tempest, N., Maclean, A., Adishesh, M., Bhullar, J., Makrydima, S., & Hapangama, D. K. (2020). Hormone Interactions in Endometrial Cancer. In MANAGEMENT OF ENDOMETRIAL CANCER (pp. 69-99). doi:10.1007/978-3-319-64513-1_6
2019
A multi-methodological approach defines sub-populations in human endometrial epithelium
Maclean, A., Bhullar, J., Vaseiva, O., Valentijn, A., Drury, J., Tempest, N., . . . Hapangama, D. (2019). A multi-methodological approach defines sub-populations in human endometrial epithelium. In HUMAN REPRODUCTION Vol. 34 (pp. 41). Retrieved from https://www.webofscience.com/
Differential expression of hormone metabolising enzymes defines endometrial epithelial sub-populations
Maclean, A., Bhullar, J., Miwa, S., von Glinicki, T., Morais, C. L. M., Martin, F., . . . Hapangama, D. (2019). Differential expression of hormone metabolising enzymes defines endometrial epithelial sub-populations. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 126 (pp. E134). Retrieved from https://www.webofscience.com/
Multi-Methodological Approach Defines Sub-Populations of Epithelial Cells in Human Endometrium.
Maclean, A., Bhullar, J., Miwa, S., von Glinicki, T., Medeiros-de-Morais, C. D. L., Martin, F. L., . . . Hapangama, D. (2019). Multi-Methodological Approach Defines Sub-Populations of Epithelial Cells in Human Endometrium.. In REPRODUCTIVE SCIENCES Vol. 26 (pp. 103A). Retrieved from https://www.webofscience.com/
Hormone Interactions in Endometrial Cancer
Kamal, A., Tempest, N., Adishesh, M., Makrydima, S., Hapangama, D. K., Maclean, A., & Bhullar, J. (2019). Hormone Interactions in Endometrial Cancer. In Management of Endometrial Cancer (pp. 69-99). doi:10.1007/9783319645131_6
2018
Optimising methodology to characterise human endometrial epithelial cell sub populations
Maclean, A., Hapangama, D., Drury, J., Bhullar, J., & Simon, S. (2018). Optimising methodology to characterise human endometrial epithelial cell sub populations. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 125 (pp. 17). Retrieved from https://www.webofscience.com/
Endometrial Stem Cell Markers: Current Concepts and Unresolved Questions
Tempest, N., Maclean, A., & Hapangama, D. K. (2018). Endometrial Stem Cell Markers: Current Concepts and Unresolved Questions. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(10), 26 pages. doi:10.3390/ijms19103240
The human fallopian tube vs endometrium: can differences in function and steroid hormone receptor expression be explained by differential hormone responsiveness?
Maclean, A., Bunni, E., Makrydima, S., Withington, A., Drury, J., & Hapangama, D. (2018). The human fallopian tube vs endometrium: can differences in function and steroid hormone receptor expression be explained by differential hormone responsiveness?. In HUMAN REPRODUCTION Vol. 33 (pp. 254). Retrieved from https://www.webofscience.com/
2017
Identification of markers of endometrial epithelial cells (EEC's) contributes to the characterisation of EEC subtypes
Maclean, A., Drury, J., & Hapangama, D. (2017). Identification of markers of endometrial epithelial cells (EEC's) contributes to the characterisation of EEC subtypes. In HUMAN REPRODUCTION Vol. 32 (pp. 264-265). Retrieved from https://www.webofscience.com/