Research outputs
2026
Uncoupling TGFβ1 signalling from collagen protein synthesis in Dupuytren's disease
Cooper, G., Gumbs, J. A., Alkharabsheh, S., Lee, K. J., Carter, A., Coleman, H., . . . Canty-laird, E. G. (2026). Uncoupling TGFβ1 signalling from collagen protein synthesis in Dupuytren's disease. JOURNAL OF PATHOLOGY, 268(4), 383-397. doi:10.1002/path.70020
2025
Uncoupling TGFβ1 signalling from collagen protein synthesis in Dupuytren’s disease
Cooper, G., Gumbs, J., Alkharabsheh, S., Lee, K., Carter, A., Coleman, H., . . . Laird, E. (n.d.). Uncoupling TGFβ1 signalling from collagen protein synthesis in Dupuytren’s disease.
Active synthesis of type I collagen homotrimer in Dupuytren’s fibrosis is unaffected by anti–TNF-α treatment
Williamson, K., Lee, K. J., Beamish, E. L., Carter, A., Gumbs, J. A., Cooper, G., . . . Canty-Laird, E. G. (2025). Active synthesis of type I collagen homotrimer in Dupuytren’s fibrosis is unaffected by anti–TNF-α treatment. JCI Insight, 10(9). doi:10.1172/jci.insight.175188
2023
Time-of-day secretome profiling reveals rhythmic ECM secretion and altered circadian ECM remodelling during skeletal muscle ageing
Sutton, E., Sarumi, D., Alamedine, M., Fawcett, S., Carter, A., Topping, A., . . . Vaughan, V. P. (2023). Time-of-day secretome profiling reveals rhythmic ECM secretion and altered circadian ECM remodelling during skeletal muscle ageing. In TISSUE ENGINEERING PART A Vol. 29 (pp. 1 page). Retrieved from https://www.webofscience.com/
ANTIOXIDANT TRANSCRIPTION FACTOR NRF2 REGULATES SKELETAL MUSCLE HOMEOSTASIS THROUGH A CIRCADIAN MECHANISM THAT IS DISRUPTED WITH AGEING
Pekovic-Vaughan, V., Sutton, E., Carter, A., Fawcett, S., Moore, H., Sarumi, D., & Bou-Gharios, G. (2023). ANTIOXIDANT TRANSCRIPTION FACTOR NRF2 REGULATES SKELETAL MUSCLE HOMEOSTASIS THROUGH A CIRCADIAN MECHANISM THAT IS DISRUPTED WITH AGEING. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 201 (pp. 4). doi:10.1016/j.freeradbiomed.2023.03.042
2021
A novel role for an antioxidant transcription factor <i>Nrf2</i> as a transcriptional repressor of the circadian molecular clock
Sutton, E., Carter, A., Fawcett, S., Sarumi, D., Copple, I., & Pekovic-Vaughan, V. (2021). A novel role for an antioxidant transcription factor <i>Nrf2</i> as a transcriptional repressor of the circadian molecular clock. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 177 (pp. 1 page). doi:10.1016/j.freeradbiomed.2021.08.103
NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions
Sutton, E., Early, J., Hughes, A., Gall, L., Carter, A., Copple, I., . . . Pekovic-Vaughan, V. (2021). NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 177 (pp. 1 page). doi:10.1016/j.freeradbiomed.2021.08.042
2020
Active synthesis of type I collagen homotrimer in Dupuytren’s fibrosis is unaffected by anti-TNF-α treatment
Williamson, K., Lee, K., Beamish, E., Carter, A., Gumbs, J., Cooper, G., . . . Canty-Laird, E. (2020). Active synthesis of type I collagen homotrimer in Dupuytren’s fibrosis is unaffected by anti-TNF-α treatment. doi:10.1101/2020.07.13.195107
2019
Antioxidant transcription factor Nrf2 and the circadian molecular clock interact in a tissue-specific, bi-directional manner
Sutton, E., Carter, A., Early, J., Fawcett, S., Sarumi, D., Bechtold, D., & Pekovic-Vaughan, V. (2019). Antioxidant transcription factor Nrf2 and the circadian molecular clock interact in a tissue-specific, bi-directional manner. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 139 (pp. S52). Retrieved from https://www.webofscience.com/
The role of Cryptochrome1/2 proteins in the regulation of TGF-β1 signalling pathway and their implication in tissue fibrosis
Sarumi, D., Carter, A., Fawcett, S. A., Sutton, E., Van derhorst, G. T. J., Kearns, V., . . . Pekovic-Vaughan, V. (2019). The role of Cryptochrome1/2 proteins in the regulation of TGF-β1 signalling pathway and their implication in tissue fibrosis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A45). Retrieved from https://www.webofscience.com/
2018
Chondrocyte specific deletion of CCN2 does not exacerbate osteoarthritis in models of post-traumatic osteoarthritis in mice
Keenan, C., Jaffa, M., Milner, P., Kanakis, I., Carter, A., Abraham, D., . . . Poulet, B. (2018). Chondrocyte specific deletion of CCN2 does not exacerbate osteoarthritis in models of post-traumatic osteoarthritis in mice. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A14). Retrieved from https://www.webofscience.com/
CCN2 DEFICIENCY IN CHONDROCYTES DOES NOT EXACERBATE OSTEOARTHRITIS IN TRAUMA-INDUCED MOUSE MODELS
Keenan, C., Milner, P., Kanakis, I., Carter, A., Abraham, D., Leask, A., . . . Poulet, B. (2018). CCN2 DEFICIENCY IN CHONDROCYTES DOES NOT EXACERBATE OSTEOARTHRITIS IN TRAUMA-INDUCED MOUSE MODELS. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S79). doi:10.1016/j.joca.2018.02.168
2016
P-18 Antioxidant transcription factor Nrf2 mediates diurnal control of cutaneous wound repair by a redox mechanism that declines with ageing
Pekovic-Vaughan, V., Carter, A., Marr, N., Roskell, C., Clegg, P., Jackson, M., & Bou-Gharios, G. (2016). P-18 Antioxidant transcription factor Nrf2 mediates diurnal control of cutaneous wound repair by a redox mechanism that declines with ageing. Free Radical Biology and Medicine, 96, s40. doi:10.1016/j.freeradbiomed.2016.04.081
CONNECTIVE TISSUE GROWTH FACTOR DEFICIENCY IN ADULT ARTICULAR CARTILAGE PROMOTES CARTILAGE DEGENERATION AT EARLY TIMEPOINTSIN MOUSE POSTTRAUMATIC OSTEOARTHRITIS
Poulet, B., Milner, P., Kanakis, I., Carter, A., Abraham, D., Leask, A., . . . Bou-Gharios, G. (2016). CONNECTIVE TISSUE GROWTH FACTOR DEFICIENCY IN ADULT ARTICULAR CARTILAGE PROMOTES CARTILAGE DEGENERATION AT EARLY TIMEPOINTSIN MOUSE POSTTRAUMATIC OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 24 (pp. S392). doi:10.1016/j.joca.2016.01.705