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Leonardo de Oliveira Martins

Dr Leonardo de Oliveira Martins
BSc, MSc, PhD

Tenure Track Fellow in Health
Electrical Engineering and Electronics

Research outputs

Selected research outputs

  1. Scalable neighbour search and alignment with uvaia (Journal article - 2024)
  2. Phylogenomic Analyses of 2,786 Genes in 158 Lineages Support a Root of the Eukaryotic Tree of Life between Opisthokonts and All Other Lineages (Journal article - 2022)
  3. Datasets for benchmarking antimicrobial resistance genes in bacterial metagenomic and whole genome sequencing (Journal article - 2022)
  4. Dynamics of competing SARS-CoV-2 variants during the Omicron epidemic in England (Journal article - 2022)
  5. Tatajuba: exploring the distribution of homopolymer tracts (Journal article - 2022)
  6. Exposure of <i>Salmonella</i> biofilms to antibiotic concentrations rapidly selects resistance with collateral tradeoffs (Journal article - 2021)
  7. Taxonomic resolution of the ribosomal RNA operon in bacteria: implications for its use with long-read sequencing. (Journal article - 2020)
  8. A Bayesian Supertree Model for Genome-Wide Species Tree Reconstruction (Journal article - 2016)
  9. Infinitely long branches and an informal test of common ancestry (Journal article - 2016)
  10. <i>SimPhy</i>: Phylogenomic Simulation of Gene, Locus, and Species Trees (Journal article - 2016)
What type of research output do you want to show?

2026

Structural and evolutionary insights into the isoprene monooxygenases

Larke-Mejia, N. L., Martins, L. D. O., & Murrell, J. C. (2026). Structural and evolutionary insights into the isoprene monooxygenases. FEMS MICROBIOLOGY ECOLOGY, 102(3). doi:10.1093/femsec/fiag004

DOI
10.1093/femsec/fiag004
Journal article

2025

<i>Staphylococcus haemolyticus</i> Population Genomics Provides Insights into Pathogenicity and Commensalism

DOI
10.1101/2025.11.08.687178
Preprint

Population structure and gene flux of Listeria monocytogenes ST121 reveal prophages as a candidate driver of adaptation and persistence in food production environments.

Gutiérrez, A. V., Matthews, M., Diaz, M., Le Viet, T., de Oliveira Martins, L., Jørgensen, F., . . . Gilmour, M. W. (2025). Population structure and gene flux of Listeria monocytogenes ST121 reveal prophages as a candidate driver of adaptation and persistence in food production environments.. Microb Genom, 11(4). doi:10.1099/mgen.0.001397

DOI
10.1099/mgen.0.001397
Journal article

Temporal dynamics of SARS-CoV-2 shedding in feces and saliva: a longitudinal study in Norfolk, United Kingdom during the 2021-2022 COVID-19 waves.

Kellingray, L., Savva, G. M., Garcia-Gutierrez, E., Snell, J., Romano, S., Yara, D. A., . . . Sayavedra, L. (2025). Temporal dynamics of SARS-CoV-2 shedding in feces and saliva: a longitudinal study in Norfolk, United Kingdom during the 2021-2022 COVID-19 waves.. Microbiology spectrum, e0319524. doi:10.1128/spectrum.03195-24

DOI
10.1128/spectrum.03195-24
Journal article

A multi-isolate genomic approach identifies diverse<i> Escherichia</i><i> coli</i> contamination and antimicrobial resistance carriage on retail foods

Astorga, G., Bloomfield, S. J., Palau, R., Janecko, N., Martins, L. D. O., Singh, D., . . . Mather, A. E. (2025). A multi-isolate genomic approach identifies diverse<i> Escherichia</i><i> coli</i> contamination and antimicrobial resistance carriage on retail foods. MICROBIAL GENOMICS, 11(10). doi:10.1099/mgen.0.001549

DOI
10.1099/mgen.0.001549
Journal article

2024

2023

Repurposing an integrated national influenza platform for genomic surveillance of SARS-CoV-2 in Ghana: a molecular epidemiological analysis

Asante, I. A., Hsu, S. N., Boatemaa, L., Kwasah, L., Adusei-Poku, M., Odoom, J. K., . . . Ampofo, W. K. (2023). Repurposing an integrated national influenza platform for genomic surveillance of SARS-CoV-2 in Ghana: a molecular epidemiological analysis. LANCET GLOBAL HEALTH, 11(7), E1075-E1085. doi:10.1016/S2214-109X(23)00189-4

DOI
10.1016/S2214-109X(23)00189-4
Journal article

The SARS-CoV-2 Alpha variant was associated with increased clinical severity of COVID-19 in Scotland: A genomics-based retrospective cohort analysis.

Pascall, D. J., Vink, E., Blacow, R., Bulteel, N., Campbell, A., Campbell, R., . . . COVID-19 Genomics UK (COG-UK) Consortium. (2023). The SARS-CoV-2 Alpha variant was associated with increased clinical severity of COVID-19 in Scotland: A genomics-based retrospective cohort analysis.. PloS one, 18(4), e0284187. doi:10.1371/journal.pone.0284187

DOI
10.1371/journal.pone.0284187
Journal article

SARS-CoV-2 mutations on diagnostic gene targets in the second wave in Zimbabwe: A retrospective genomic analysis

Nyagupe, C., Martins, L. D. O., Gumbo, H., Mashe, T., Takawira, T., Maeka, K. K., . . . Mavenyengwa, R. T. (2023). SARS-CoV-2 mutations on diagnostic gene targets in the second wave in Zimbabwe: A retrospective genomic analysis. SAMJ SOUTH AFRICAN MEDICAL JOURNAL, 113(3), 141-147. doi:10.7196/SAMJ.2023.v113i3.16762

DOI
10.7196/SAMJ.2023.v113i3.16762
Journal article

2022

Datasets for benchmarking antimicrobial resistance genes in bacterial metagenomic and whole genome sequencing

Raphenya, A. R., Robertson, J., Jamin, C., de Oliveira Martins, L., Maguire, F., McArthur, A. G., & Hays, J. P. (2022). Datasets for benchmarking antimicrobial resistance genes in bacterial metagenomic and whole genome sequencing. SCIENTIFIC DATA, 9(1). doi:10.1038/s41597-022-01463-7

DOI
10.1038/s41597-022-01463-7
Journal article

Dynamics of competing SARS-CoV-2 variants during the Omicron epidemic in England

Eales, O., Martins, L. D. O., Page, A. J., Wang, H., Bodinier, B., Tang, D., . . . Chadeau-Hyam, M. (2022). Dynamics of competing SARS-CoV-2 variants during the Omicron epidemic in England. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-32096-4

DOI
10.1038/s41467-022-32096-4
Journal article

SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2

Eales, O., Page, A. J., de Oliveira Martins, L., Wang, H., Bodinier, B., Haw, D., . . . Elliott, P. (2022). SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2. BMC Infectious Diseases, 22(1). doi:10.1186/s12879-022-07628-4

DOI
10.1186/s12879-022-07628-4
Journal article

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

Tegally, H., San, J. E., Cotten, M., Moir, M., Tegomoh, B., Mboowa, G., . . . Wilkinson, E. (2022). The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance. SCIENCE, 378(6615), 42-+. doi:10.1126/science.abq5358

DOI
10.1126/science.abq5358
Journal article

Phylogenomic Analyses of 2,786 Genes in 158 Lineages Support a Root of the Eukaryotic Tree of Life between Opisthokonts and All Other Lineages

Ceron-Romero, M. A., Fonseca, M. M., de Oliveira Martins, L., Posada, D., & Katz, L. A. (2022). Phylogenomic Analyses of 2,786 Genes in 158 Lineages Support a Root of the Eukaryotic Tree of Life between Opisthokonts and All Other Lineages. GENOME BIOLOGY AND EVOLUTION, 14(8). doi:10.1093/gbe/evac119

DOI
10.1093/gbe/evac119
Journal article

Tatajuba: exploring the distribution of homopolymer tracts

Martins, L. D. O., Bloomfield, S., Stoakes, E., Grant, A., Page, A. J., & Mather, A. E. (2022). Tatajuba: exploring the distribution of homopolymer tracts. NAR GENOMICS AND BIOINFORMATICS, 4(1). doi:10.1093/nargab/lqac003

DOI
10.1093/nargab/lqac003
Journal article

Replacement of the Alpha variant of SARS-CoV-2 by the Delta variant in Lebanon between April and June 2021

Merhi, G., Trotter, A. J., Martins, L. D. O., Koweyes, J., Le-Viet, T., Abou Naja, H., . . . Tokajian, S. (2022). Replacement of the Alpha variant of SARS-CoV-2 by the Delta variant in Lebanon between April and June 2021. MICROBIAL GENOMICS, 8(7). doi:10.1099/mgen.0.000838

DOI
10.1099/mgen.0.000838
Journal article

2021

SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2

DOI
10.1101/2021.12.17.21267925
Preprint

Exposure of <i>Salmonella</i> biofilms to antibiotic concentrations rapidly selects resistance with collateral tradeoffs

Trampari, E., Holden, E. R., Wickham, G. J., Ravi, A., Martins, L. D. O., Savva, G. M., & Webber, M. A. (2021). Exposure of <i>Salmonella</i> biofilms to antibiotic concentrations rapidly selects resistance with collateral tradeoffs. NPJ BIOFILMS AND MICROBIOMES, 7(1). doi:10.1038/s41522-020-00178-0

DOI
10.1038/s41522-020-00178-0
Journal article

Genomic epidemiology and the role of international and regional travel in the SARS-CoV-2 epidemic in Zimbabwe: a retrospective study of routinely collected surveillance data

Mashe, T., Takawira, F. T., Martins, L. D. O., Gudza-Mugabe, M., Chirenda, J., Munyanyi, M., . . . Mhlanga, G. (2021). Genomic epidemiology and the role of international and regional travel in the SARS-CoV-2 epidemic in Zimbabwe: a retrospective study of routinely collected surveillance data. LANCET GLOBAL HEALTH, 9(12), E1658-E1666. doi:10.1016/S2214-109X(21)00434-4

DOI
10.1016/S2214-109X(21)00434-4
Journal article

A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa

Wilkinson, E., Giovanetti, M., Tegally, H., San, J. E., Lessells, R., Cuadros, D., . . . de Oliveira, T. (2021). A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa. SCIENCE, 374(6566), 423-+. doi:10.1126/science.abj4336

DOI
10.1126/science.abj4336
Journal article

Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study.

Twohig, K. A., Nyberg, T., Zaidi, A., Thelwall, S., Sinnathamby, M. A., Aliabadi, S., . . . COVID-19 Genomics UK (COG-UK) consortium. (2021). Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study.. The Lancet. Infectious diseases, 22(1), 35-42. doi:10.1016/s1473-3099(21)00475-8

DOI
10.1016/s1473-3099(21)00475-8
Journal article

The impact of SARS-CoV-2 infection in children with rheumatic/autoinflammatory diseases on immunosuppressive treatment: a single centre experience

Maritsi, D. N., Krepis, P., Vartzelis, G., Syggelou, A., & Tsolia, M. N. (2023). The impact of SARS-CoV-2 infection in children with rheumatic/autoinflammatory diseases on immunosuppressive treatment: a single centre experience. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 41(9), S4-S5. doi:10.1038/s41586-021-03470-x

DOI
10.1038/s41586-021-03470-x
Journal article

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Collier, D. A., De Marco, A., Ferreira, I. A. T. M., Meng, B., Datir, R. P., Walls, A. C., . . . Gupta, R. K. (2021). Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies. NATURE, 593(7857), 136-+. doi:10.1038/s41586-021-03412-7

DOI
10.1038/s41586-021-03412-7
Journal article

Surveillance of SARS-CoV-2 in Zimbabwe shows dominance of variants of concern

Mashe, T., Takawira, F. T., Gumbo, H., Juru, A., Nyagupe, C., Maeka, K. K., . . . Simbi, R. (2021). Surveillance of SARS-CoV-2 in Zimbabwe shows dominance of variants of concern. LANCET MICROBE, 2(5), E177. doi:10.1016/S2666-5247(21)00061-6

DOI
10.1016/S2666-5247(21)00061-6
Journal article

Phylogenomic Analyses Of 2,786 Genes In 158 Lineages Support a Root of The Eukaryotic Tree of Life Between Opisthokonts (Animals, Fungi and Their Microbial Relatives) and All Other Lineages

DOI
10.1101/2021.02.26.433005
Preprint

SARS- CoV-2 variants of concern dominate in Lahore, Pakistan in April 2021

Sarwar, M. B., Yasir, M., Alikhan, N. -F., Afzal, N., Martins, L. D. O., Le Viet, T., . . . Jahan, S. (2021). SARS- CoV-2 variants of concern dominate in Lahore, Pakistan in April 2021. MICROBIAL GENOMICS, 7(11). doi:10.1099/mgen.0.000693

DOI
10.1099/mgen.0.000693
Journal article

2020

Experimental evolution selects clinically relevant antibiotic resistance in biofilms but with collateral tradeoffs

Trampari, E., Holden, E., Wickham, G., Ravi, A., Prischi, F., Martins, L. D. O., . . . Webber, M. (2020). Experimental evolution selects clinically relevant antibiotic resistance in biofilms but with collateral tradeoffs. Access Microbiology, 2(1). doi:10.1099/acmi.mim2019.po0001

DOI
10.1099/acmi.mim2019.po0001
Journal article

2019

Taxonomic resolution of the ribosomal RNA operon in bacteria: Implications for its use with long read sequencing

DOI
10.1101/626093
Preprint

Antibiotics select for novel pathways of resistance in biofilms

DOI
10.1101/605212
Preprint

Nanoneedle-Mediated Stimulation of Cell Mechanotransduction Machinery

Hansel, C. S., Crowder, S. W., Cooper, S., Gopal, S., Pardelha da Cruz, M. J., Martins, L. D. O., . . . Stevens, M. M. (2019). Nanoneedle-Mediated Stimulation of Cell Mechanotransduction Machinery. ACS NANO, 13(3), 2913-2926. doi:10.1021/acsnano.8b06998

DOI
10.1021/acsnano.8b06998
Journal article

2017

Species Tree Estimation from Genome-Wide Data with guenomu

de Oliveira Martins, L., & Posada, D. (2017). Species Tree Estimation from Genome-Wide Data with guenomu. In BIOINFORMATICS, VOL I: DATA, SEQUENCE ANALYSIS, AND EVOLUTION, 2ND EDITION (Vol. 1525, pp. 461-478). doi:10.1007/978-1-4939-6622-6_18

DOI
10.1007/978-1-4939-6622-6_18
Chapter

2016

A Bayesian Supertree Model for Genome-Wide Species Tree Reconstruction

De Oliveira Martins, L., Mallo, D., & Posada, D. (2016). A Bayesian Supertree Model for Genome-Wide Species Tree Reconstruction. SYSTEMATIC BIOLOGY, 65(3), 397-416. doi:10.1093/sysbio/syu082

DOI
10.1093/sysbio/syu082
Journal article

Infinitely long branches and an informal test of common ancestry

de Oliveira Martins, L., & Posada, D. (2016). Infinitely long branches and an informal test of common ancestry. BIOLOGY DIRECT, 11. doi:10.1186/s13062-016-0120-y

DOI
10.1186/s13062-016-0120-y
Journal article

<i>SimPhy</i>: Phylogenomic Simulation of Gene, Locus, and Species Trees

Mallo, D., De Oliveira Martins, L., & Posada, D. (2016). <i>SimPhy</i>: Phylogenomic Simulation of Gene, Locus, and Species Trees. SYSTEMATIC BIOLOGY, 65(2), 334-344. doi:10.1093/sysbio/syv082

DOI
10.1093/sysbio/syv082
Journal article

2015

Infinitely Long Branches and an Informal Test of Common Ancestry

DOI
10.1101/023903
Preprint

Species Tree Estimation from Genome-wide Data with Guenomu

DOI
10.1101/023861
Preprint

<i>SimPhy</i>: Phylogenomic Simulation of Gene, Locus and Species Trees

DOI
10.1101/021709
Preprint

Phylogenetic Likelihood

de Oliveira Martins, L., Mallo, D., & Posada, D. (n.d.). Phylogenetic Likelihood. Wiley. doi:10.1002/9780470015902.a0005141

DOI
10.1002/9780470015902.a0005141
Other

2014

Estimation of Species Trees

Mallo, D., de Oliveira Martins, L., & Posada, D. (n.d.). Estimation of Species Trees. Wiley. doi:10.1002/9780470015902.a0025781

DOI
10.1002/9780470015902.a0025781
Other

Unsorted Homology within Locus and Species Trees

Mallo, D., De Oliveira Martins, L., & Posada, D. (2014). Unsorted Homology within Locus and Species Trees. SYSTEMATIC BIOLOGY, 63(6), 988-992. doi:10.1093/sysbio/syu050

DOI
10.1093/sysbio/syu050
Journal article

Testing for Universal Common Ancestry

de Oliveira Martins, L., & Posada, D. (2014). Testing for Universal Common Ancestry. SYSTEMATIC BIOLOGY, 63(5), 838-842. doi:10.1093/sysbio/syu041

DOI
10.1093/sysbio/syu041
Journal article

2013

Codon pairs of the HIV-1 <i>vif</i> gene correlate with CD4+T cell count

Bizinoto, M. C., Yabe, S., Leal, E., Kishino, H., de Oliveira Martins, L., de Lima, M. L., . . . Janini, L. M. (2013). Codon pairs of the HIV-1 <i>vif</i> gene correlate with CD4+T cell count. BMC INFECTIOUS DISEASES, 13. doi:10.1186/1471-2334-13-173

DOI
10.1186/1471-2334-13-173
Journal article

2012

2010

Evolutionary Process of Deep-Sea <i>Bathymodiolus</i> Mussels

Miyazaki, J. -I., de Oliveira Martins, L., Fujita, Y., Matsumoto, H., & Fujiwara, Y. (2010). Evolutionary Process of Deep-Sea <i>Bathymodiolus</i> Mussels. PLOS ONE, 5(4). doi:10.1371/journal.pone.0010363

DOI
10.1371/journal.pone.0010363
Journal article

Lineage-specific positive selection at the merozoite surface protein 1 (<i>msp1</i>) locus of <i>Plasmodium vivax</i> and related simian malaria parasites

Sawai, H., Otani, H., Arisue, N., Palacpac, N., de Oliveira Martins, L., Pathirana, S., . . . Tanabe, K. (2010). Lineage-specific positive selection at the merozoite surface protein 1 (<i>msp1</i>) locus of <i>Plasmodium vivax</i> and related simian malaria parasites. BMC EVOLUTIONARY BIOLOGY, 10. doi:10.1186/1471-2148-10-52

DOI
10.1186/1471-2148-10-52
Journal article

Distribution of distances between topologies and its effect on detection of phylogenetic recombination

de Oliveira Martins, L., & Kishino, H. (2010). Distribution of distances between topologies and its effect on detection of phylogenetic recombination. ANNALS OF THE INSTITUTE OF STATISTICAL MATHEMATICS, 62(1), 145-159. doi:10.1007/s10463-009-0259-8

DOI
10.1007/s10463-009-0259-8
Journal article

2008

Evolutionary Dynamics of HIV-1 BF and CB Recombinants and Its Parental Counterparts in South America

Evolutionary Dynamics of HIV-1 BF and CB Recombinants and Its Parental Counterparts in South America (2008). Retrovirology: Research and Treatment, 1, 1-14. doi:10.4137/rrt.s1045

DOI
10.4137/rrt.s1045
Journal article

Phylogenetic Detection of Recombination with a Bayesian Prior on the Distance between Trees

Martins, L. D. O., Leal, E., & Kishino, H. (2008). Phylogenetic Detection of Recombination with a Bayesian Prior on the Distance between Trees. PLOS ONE, 3(7). doi:10.1371/journal.pone.0002651

DOI
10.1371/journal.pone.0002651
Journal article

2007

A likelihood-based index of protein-protein binding affinities with application to influenza HA escape from antibodies

Watabe, T., Kishino, H., Martins, L. D. O., & Kitazoe, Y. (2007). A likelihood-based index of protein-protein binding affinities with application to influenza HA escape from antibodies. MOLECULAR BIOLOGY AND EVOLUTION, 24(8), 1627-1638. doi:10.1093/molbev/msm079

DOI
10.1093/molbev/msm079
Journal article

2006

Evolutionary relationships of deep-sea mussels inferred by mitochondrial DNA sequences

Iwasaki, H., Kyuno, A., Shintaku, M., Fujita, Y., Fujiwara, Y., Fujikura, K., . . . Miyazaki, J. -I. (2006). Evolutionary relationships of deep-sea mussels inferred by mitochondrial DNA sequences. MARINE BIOLOGY, 149(5), 1111-1122. doi:10.1007/s00227-006-0268-6

DOI
10.1007/s00227-006-0268-6
Journal article

2005

Phylogeography of loaches of the <i>Genus lefua</i> (Balitoridae, Cypriniformes) inferred from mitochondrial DNA sequences

Mihara, M., Sakai, T., Nakao, K., de Oliveira Martins, L., Hosoya, K., & Miyazaki, J. -I. (2005). Phylogeography of loaches of the <i>Genus lefua</i> (Balitoridae, Cypriniformes) inferred from mitochondrial DNA sequences. ZOOLOGICAL SCIENCE, 22(2), 157-168. doi:10.2108/zsj.22.157

DOI
10.2108/zsj.22.157
Journal article