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Elizabeth Laird

Dr Elizabeth Laird
DipStat(Open), BSc, PGCertHE, PhD, FHEA

Publications

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2024

Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community.

Dalby, M. J., Pekovic-Vaughan, V., Shanley, D. P., Swift, J., White, L. J., & Canty-Laird, E. G. (2024). Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community.. BioEssays : news and reviews in molecular, cellular and developmental biology, 46(5), e2300223. doi:10.1002/bies.202300223

DOI
10.1002/bies.202300223
Journal article

2023

2022

Multimodal analysis of the differential effects of cyclic strain on collagen isoform composition, fibril architecture and biomechanics of tissue engineered tendon

Janvier, A. J., Pendleton, E. G., Mortensen, L. J., Green, D. C., Henstock, J. R., & Canty-Laird, E. G. (2022). Multimodal analysis of the differential effects of cyclic strain on collagen isoform composition, fibril architecture and biomechanics of tissue engineered tendon. JOURNAL OF TISSUE ENGINEERING, 13. doi:10.1177/20417314221130486

DOI
10.1177/20417314221130486
Journal article

2021

Characterisation of key proteoglycans in the cranial cruciate ligaments (CCLs) from two dog breeds with different predispositions to CCL disease and rupture.

Allaith, S., Tew, S. R., Hughes, C. E., Clegg, P. D., Canty-Laird, E. G., & Comerford, E. J. (2021). Characterisation of key proteoglycans in the cranial cruciate ligaments (CCLs) from two dog breeds with different predispositions to CCL disease and rupture.. Veterinary journal (London, England : 1997), 272, 105657. doi:10.1016/j.tvjl.2021.105657

DOI
10.1016/j.tvjl.2021.105657
Journal article

Intra-Fascicular Chondroid-like Bodies in the Ageing Equine Superficial Digital Flexor Tendon comprise Glycosaminoglycans and Type II Collagen.

Ali, O. J., Ehrle, A., Comerford, E. J., Canty-Laird, E. G., Mead, A., Clegg, P. D., & Maddox, T. W. (2021). Intra-Fascicular Chondroid-like Bodies in the Ageing Equine Superficial Digital Flexor Tendon comprise Glycosaminoglycans and Type II Collagen.. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. doi:10.1002/jor.25002

DOI
10.1002/jor.25002
Journal article

2020

2019

Nanotopography of substrates directs the deposition of fibrillar collagen by corneal stromal cells and deposition is accelerated by macromolecular crowding

O'Loughlin, D. A., Kearns, V. R., Levis, H. J., Sheridan, C., & Canty-Laird, E. G. (2019). Nanotopography of substrates directs the deposition of fibrillar collagen by corneal stromal cells and deposition is accelerated by macromolecular crowding. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 60. Retrieved from https://www.webofscience.com/

Conference Paper

2018

2017

Ligament-Derived Stem Cells: Identification, Characterisation, and Therapeutic Application

Lee, K. J., Clegg, P. D., Comerford, E. J., & Canty-Laird, E. G. (2017). Ligament-Derived Stem Cells: Identification, Characterisation, and Therapeutic Application. STEM CELLS INTERNATIONAL, 2017. doi:10.1155/2017/1919845

DOI
10.1155/2017/1919845
Journal article

2016

Impact of ageing on TGF-Beta stimulated type I collagen production

Gumbs, J. A., Chapman, N. R., Young, D. A., Clegg, P. D., & Canty-Laird, E. G. (2016). Impact of ageing on TGF-Beta stimulated type I collagen production. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A15). Retrieved from https://www.webofscience.com/

Conference Paper

Application of shortwave ultrasound to tendon-like constructs cultured from bone marrow derived mesenchymal stem cells in vitro produces tissue of greater strength

Application of Shortwave Ultrasound to Tendon‐Like Constructs Cultured from Bone Marrow Derived Mesenchymal Stem Cells <i>in vitro</i> Produces Tissue of Greater Strength (2016). In Equine Veterinary Journal Vol. 48 (pp. 27-28). Wiley. doi:10.1111/evj.54_12612

DOI
10.1111/evj.54_12612
Conference Paper

Proteomic differences between native and tissue-engineered tendon and ligament

Kharaz, Y. A., Tew, S. R., Peffers, M., Canty-Laird, E. G., & Comerford, E. (2016). Proteomic differences between native and tissue-engineered tendon and ligament. PROTEOMICS, 16(10), 1547-1556. doi:10.1002/pmic.201500459

DOI
10.1002/pmic.201500459
Journal article

Investigating the effects of high-glucose exposure on DNA methylation and gene transcription in musculoskeletal cells

Tregilgas, L., Reynard, L. N., Tew, S. R., Loughlin, J., Clegg, P. D., & Canty-Laird, E. G. (2016). INVESTIGATING THE EFFECTS OF HIGH-GLUCOSE EXPOSURE ON DNA METHYLATION AND GENE TRANSCRIPTION IN MUSCULOSKELETAL CELLS. In OSTEOARTHRITIS AND CARTILAGE Vol. 24 (pp. S228). doi:10.1016/j.joca.2016.01.440

DOI
10.1016/j.joca.2016.01.440
Conference Paper

Modest, transient high-glucose exposure has the potential to alter DNA methylation profiles of musculoskeletal cells and induce DNA damage

Tregilgas, L., Reynard, L., Tew, S., Loughlin, J., Clegg, P., & Canty-Laird, E. (2016). Modest, transient high-glucose exposure has the potential to alter DNA methylation profiles of musculoskeletal cells and induce DNA damage. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A14). Retrieved from https://www.webofscience.com/

Conference Paper

2015

PI-3K signalling is a consensus pathway in musculoskeletal de- and re-differentiation

Mueller, A. J., Tew, S. R., Canty-Laird, E. G., & Clegg, P. D. (2015). PI-3K signalling is a consensus pathway in musculoskeletal de- and re-differentiation. In Bone and Joint Journal Vol. 97-B. British Editorial Society of Bone and Joint Surgery. Retrieved from http://www.bjjprocs.boneandjoint.org.uk/content/97-B/SUPP_11/8

Conference Paper

2014

Biosynthetic alterations in collagen production in ruptured canine anterior cruciate ligament

Under pressure: the cell's response (2014). In International Journal of Experimental Pathology Vol. 95. Wiley. doi:10.1111/iep.12078

DOI
10.1111/iep.12078
Conference Paper

2012

Collagen biosynthesis and modifying enzymes

Jupe, S. (n.d.). Collagen biosynthesis and modifying enzymes. Reactome - a curated knowledgebase of biological pathways, 41. doi:10.3180/react_121139.1

DOI
10.3180/react_121139.1
Journal article

Stepwise proteolytic activation of type I procollagen to collagen within the secretory pathway of tendon fibroblasts <i>in situ</i>

Canty-Laird, E. G., Lu, Y., & Kadler, K. E. (2012). Stepwise proteolytic activation of type I procollagen to collagen within the secretory pathway of tendon fibroblasts <i>in situ</i>. BIOCHEMICAL JOURNAL, 441, 707-717. doi:10.1042/BJ20111379

DOI
10.1042/BJ20111379
Journal article

2011

Evaluation of the relative inhibition of intracellular and extracellular procollagen C-proteinase (PCP) activity in tendon explants by synthetic PCP inhibitors (PCPi)

British Society for Matrix Biology - Spring 2011 Meeting Report (2011). In International Journal of Experimental Pathology Vol. 92 (pp. A1-A38). Wiley. doi:10.1111/j.1365-2613.2011.00780.x

DOI
10.1111/j.1365-2613.2011.00780.x
Conference Paper

Expression of the osteoarthritis-associated gene <i>GDF5</i> is modulated epigenetically by DNA methylation

Reynard, L. N., Bui, C., Canty-Laird, E. G., Young, D. A., & Loughlin, J. (2011). Expression of the osteoarthritis-associated gene <i>GDF5</i> is modulated epigenetically by DNA methylation. HUMAN MOLECULAR GENETICS, 20(17), 3450-3460. doi:10.1093/hmg/ddr253

DOI
10.1093/hmg/ddr253
Journal article

2010

An experimental model for studying the biomechanics of embryonic tendon: Evidence that the development of mechanical properties depends on the actinomyosin machinery

Kalson, N. S., Holmes, D. F., Kapacee, Z., Otermin, I., Lu, Y., Ennos, R. A., . . . Kadler, K. E. (2010). An experimental model for studying the biomechanics of embryonic tendon: Evidence that the development of mechanical properties depends on the actinomyosin machinery. MATRIX BIOLOGY, 29(8), 678-689. doi:10.1016/j.matbio.2010.08.009

DOI
10.1016/j.matbio.2010.08.009
Journal article

First evidence of bone morphogenetic protein 1 expression and activity in sheep ovarian follicles

Canty-Laird, E., Carre, G. -A., Mandon-Pepin, B., Kadler, K. E., & Fabre, S. (2010). First Evidence of Bone Morphogenetic Protein 1 Expression and Activity in Sheep Ovarian Follicles. BIOLOGY OF REPRODUCTION, 83(1), 138-146. doi:10.1095/biolreprod.109.082115

DOI
10.1095/biolreprod.109.082115
Journal article

2009

Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid

Berry, R., Jowitt, T. A., Ferrand, J., Roessle, M., Grossmann, J. G., Canty-Laird, E. G., . . . Baldock, C. (2009). Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(21), 8561-8566. doi:10.1073/pnas.0812178106

DOI
10.1073/pnas.0812178106
Journal article

Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid

Berry, R., Jowitt, T. A., Ferrand, J., Roessle, M., Grossmann, J. G., Canty-Laird, E. G., . . . Baldock, C. (2009). Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid. Proceedings of the National Academy of Sciences, 106(21), 8561-8566. doi:10.1073/pnas.0812178106

DOI
10.1073/pnas.0812178106
Journal article

2008

Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators

Kadler, K. E., Hill, A., & Canty-Laird, E. G. (2008). Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators. CURRENT OPINION IN CELL BIOLOGY, 20(5), 495-501. doi:10.1016/j.ceb.2008.06.008

DOI
10.1016/j.ceb.2008.06.008
Journal article

Active negative control of collagen fibrillogenesis in vivo. Intracellular cleavage of the type I procollagen propeptides in tendon fibroblasts without intracellular fibrils

Humphries, S. M., Lu, Y., Canty, E. G., & Kadler, K. E. (2008). Active negative control of collagen fibrillogenesis <i>in vivo</i> -: Intracellular cleavage of the type I procollagen propeptides in tendon fibroblasts without intracellular fibrils. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(18), 12129-12135. doi:10.1074/jbc.M708198200

DOI
10.1074/jbc.M708198200
Journal article

2006

Actin filaments are required for fibripositor-mediated collagen fibril alignment in tendon

Canty, E. G., Starborg, T., Lu, Y., Humphries, S. M., Holmes, D. F., Meadows, R. S., . . . Kadler, K. E. (2006). Actin filaments are required for fibripositor-mediated collagen fibril alignment in tendon. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(50), 38592-38598. doi:10.1074/jbc.M607581200

DOI
10.1074/jbc.M607581200
Journal article

A complete domain structure of Drosophila tolloid is required for cleavage of short gastrulation

Canty, E. G., Garrigue-Antar, L., & Kadler, K. E. (2006). A complete domain structure of <i>Drosophila</i> tolloid is required for cleavage of short gastrulation. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(19), 13258-13267. doi:10.1074/jbc.M510483200

DOI
10.1074/jbc.M510483200
Journal article

2005

Procollagen trafficking, processing and fibrillogenesis

Canty, E. G., & Kadler, K. E. (2005). Procollagen trafficking, processing and fibrillogenesis. JOURNAL OF CELL SCIENCE, 118(7), 1341-1353. doi:10.1242/jcs.01731

DOI
10.1242/jcs.01731
Journal article

2004

Coalignment of plasma membrane channels and protrusions (fibripositors) specifies the parallelism of tendon

Canty, E. G., Lu, Y. H., Meadows, R. S., Shaw, M. K., Holmes, D. F., & Kadler, K. E. (2004). Coalignment of plasma membrane channels and protrusions (fibripositors) specifies the parallelism of tendon. JOURNAL OF CELL BIOLOGY, 165(4), 553-563. doi:10.1083/jcb.200312071

DOI
10.1083/jcb.200312071
Journal article

2002

Collagen fibril biosynthesis in tendon: a review and recent insights

Canty, E. G., & Kadler, K. E. (2002). Collagen fibril biosynthesis in tendon: a review and recent insights. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY, 133(4), 979-985. doi:10.1016/S1095-6433(02)00212-X

DOI
10.1016/S1095-6433(02)00212-X
Journal article

1999

Identification of novel pro-alpha2(IX) collagen gene mutations in two families with distinctive oligo-epiphyseal forms of multiple epiphyseal dysplasia

Holden, P., Canty, E. G., Mortier, G. R., Zabel, B., Spranger, J., Carr, A., . . . Briggs, M. D. (1999). Identification of novel pro-α2(IX) collagen gene mutations in two families with distinctive olgo-epiphyseal forms of multiple epiphyseal dysplasia. AMERICAN JOURNAL OF HUMAN GENETICS, 65(1), 31-38. doi:10.1086/302440

DOI
10.1086/302440
Journal article