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Thesis / Dissertation

2025

Redefining LNP composition: phospholipid and sterol-driven modulation of mRNA expression and immune outcomes

Hussain, M., Muglikar, A., Brain, D. E., Plant-Hately, A. J., Liptrott, N. J., McLoughlin, D. M., & Perrie, Y. (2025). Redefining LNP composition: phospholipid and sterol-driven modulation of mRNA expression and immune outcomes. RSC Pharmaceutics. doi:10.1039/d5pm00150a

DOI: 10.1039/d5pm00150a
: Journal article

2023

Investigating the impact of, novel, therapeutic delivery systems on immunological responses - determination of short, and long-term, exposure effects

Brain, D. (2023, June 21). Investigating the impact of, novel, therapeutic delivery systems on immunological responses - determination of short, and long-term, exposure effects.

: Thesis / Dissertation

2022

Exposure of the Basophilic Cell Line KU812 to Liposomes Reveals Activation Profiles Associated with Potential Anaphylactic Responses Linked to Physico-Chemical Characteristics

Plant-Hately, A. J., Eryilmaz, B., David, C. A. W., Brain, D. E., Heaton, B. J., Perrie, Y., & Liptrott, N. J. (2022). Exposure of the Basophilic Cell Line KU812 to Liposomes Reveals Activation Profiles Associated with Potential Anaphylactic Responses Linked to Physico-Chemical Characteristics. PHARMACEUTICS, 14(11). doi:10.3390/pharmaceutics14112470

DOI: 10.3390/pharmaceutics14112470
: Journal article

Exposure of human immune cells, to the antiretrovirals efavirenz and lopinavir, leads to lower glucose uptake and altered bioenergetic cell profiles through interactions with SLC2A1

Heaton, B. J., Jensen, R. L., Line, J., David, C. A. W., Brain, D. E., Chadwick, A. E., & Liptrott, N. J. (2022). Exposure of human immune cells, to the antiretrovirals efavirenz and lopinavir, leads to lower glucose uptake and altered bioenergetic cell profiles through interactions with SLC2A1. BIOMEDICINE & PHARMACOTHERAPY, 150. doi:10.1016/j.biopha.2022.112999

DOI: 10.1016/j.biopha.2022.112999
: Journal article

2021

Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19

Brain, D., Plant-Hately, A., Heaton, B., Arshad, U., David, C., Hedrich, C., . . . Liptrott, N. J. (2021). Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19. ADVANCED DRUG DELIVERY REVIEWS, 178. doi:10.1016/j.addr.2021.113848

DOI: 10.1016/j.addr.2021.113848
: Journal article