Publications
Selected publications
- Translational regulation contributes to the secretory response of chondrocytic cells following exposure to Interleukin-1β (Journal article - 2019)
- Cross-species gene modules emerge from a systems biology approach to osteoarthritis (Journal article - 2017)
- A systems biology approach to defining regulatory mechanisms for cartilage and tendon cell phenotypes (Journal article - 2016)
- RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes (Journal article - 2016)
- Transcriptome‐Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes (Journal article - 2014)
2023
Analysis of RNA Polyadenylation in Healthy and Osteoarthritic Human Articular Cartilage
Winstanley-Zarach, P., Rot, G., Kuba, S., Smagul, A., Peffers, M. J. J., & Tew, S. R. R. (2023). Analysis of RNA Polyadenylation in Healthy and Osteoarthritic Human Articular Cartilage. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(7). doi:10.3390/ijms24076611
Editorial: Epigenetic regulation of the musculoskeletal system in health, disease, and aging
Goljanek-Whysall, K., Tew, S., Peffers, M. J., & Kanakis, I. (2023). Editorial: Epigenetic regulation of the musculoskeletal system in health, disease, and aging. FRONTIERS IN ENDOCRINOLOGY, 14. doi:10.3389/fendo.2023.1143210
2022
Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations
Al-Maslamani, N. A., Oldershaw, R., Tew, S., Curran, J., D'Hooghe, P., Yamamoto, K., & Horn, H. F. (2022). Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations. CELLS, 11(24). doi:10.3390/cells11244011
2021
Characterisation of key proteoglycans in the cranial cruciate ligaments (CCLs) from two dog breeds with different predispositions to CCL disease and rupture.
Allaith, S., Tew, S. R., Hughes, C. E., Clegg, P. D., Canty-Laird, E. G., & Comerford, E. J. (2021). Characterisation of key proteoglycans in the cranial cruciate ligaments (CCLs) from two dog breeds with different predispositions to CCL disease and rupture.. Veterinary journal (London, England : 1997), 272, 105657. doi:10.1016/j.tvjl.2021.105657
2019
Insulin-like growth factor binding protein (IGFBP6) is a cross-species tendon marker.
Turlo, A. J., Mueller-Breckenridge, A. J., Zamboulis, D. E., Tew, S. R., Canty-Laird, E. G., & Clegg, P. D. (2019). Insulin-like growth factor binding protein (IGFBP6) is a cross-species tendon marker.. European Cells and Materials, 38, 123-136. doi:10.22203/ecm.v038a10
Translational regulation contributes to the secretory response of chondrocytic cells following exposure to Interleukin-1β
Mcdermott, B., Peffers, M., McDonagh, B., & Tew, S. R. (2019). Translational regulation contributes to the secretory response of chondrocytic cells following exposure to Interleukin-1β. Journal of Biological Chemistry, 294(35), 13027-13029. doi:10.1074/jbc.RA118.006865
Evidence for alternative polyadenylation of the ADAMTS5 mRNA creating a heterogenous pool of transcripts that differ in their response to post-transcriptional cues
McDermott, B. T., Chinaemerem, O., Chesters, L., & Tew, S. R. (2019). Evidence for alternative polyadenylation of the ADAMTS5 mRNA creating a heterogenous pool of transcripts that differ in their response to post-transcriptional cues. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A27). Retrieved from https://www.webofscience.com/
2018
The emerging fibroblast-like synoviocyte channelome
Tew, S. R., & Barrett-Jolley, R. (2018). The emerging fibroblast-like synoviocyte channelome. EXPERIMENTAL PHYSIOLOGY, 103(8), 1043-1044. doi:10.1113/EP087087
Variations in internal structure, composition and protein distribution between intra- and extra-articular knee ligaments and tendons
Kharaz, Y. A., Canty-Laird, E. G., Tew, S. R., & Comerford, E. J. (2018). Variations in internal structure, composition and protein distribution between intra- and extra-articular knee ligaments and tendons. JOURNAL OF ANATOMY, 232(6), 943-955. doi:10.1111/joa.12802
CHARACTERISATION OF STEM CELL POPULATIONS WITHIN NORMAL AND RUPTURED ANTERIOR CRUCIATE LIGAMENTS'
Barrow, M., Tew, S., Comerford, E., McNicholas, M., & Oldershaw, R. (2018). CHARACTERISATION OF STEM CELL POPULATIONS WITHIN NORMAL AND RUPTURED ANTERIOR CRUCIATE LIGAMENTS'. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S405-S406). doi:10.1016/j.joca.2018.02.786
THE EFFECT OF U3 SNORNA KNOCKDOWN ON THE CHONDROCYTE PROTEOME
Smagul, A., Tew, S., & Peffers, M. J. (2018). THE EFFECT OF U3 SNORNA KNOCKDOWN ON THE CHONDROCYTE PROTEOME. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S165). doi:10.1016/j.joca.2018.02.359
Interaction with macrophages attenuates equine fibroblast-like synoviocyte ADAMTS5 (aggrecanase-2) gene expression following inflammatory stimulation
Morgan, R. E., Clegg, P. D., Hunt, J. A., Innes, J. F., & Tew, S. R. (2018). Interaction with macrophages attenuates equine fibroblast-like synoviocyte ADAMTS5 (aggrecanase-2) gene expression following inflammatory stimulation. JOURNAL OF ORTHOPAEDIC RESEARCH, 36(08), 2178-2185. doi:10.1002/jor.23891
2017
Cross-species gene modules emerge from a systems biology approach to osteoarthritis
Mueller, A. J., Canty-Laird, E. G., Clegg, P. D., & Tew, S. R. (2017). Cross-species gene modules emerge from a systems biologyapproach to osteoarthritis. NPJ Systems Biology and Applications, 3. doi:10.1038/s41540-017-0014-3
2016
A systems biology approach to defining regulatory mechanisms for cartilage and tendon cell phenotypes
Mueller, A. J., Tew, S. R., Vasieva, O., Clegg, P. D., & Canty-Laird, E. G. (2016). A systems biology approach to defining regulatory mechanisms for cartilage and tendon cell phenotypes. SCIENTIFIC REPORTS, 6, 1-14. doi:10.1038/srep33956
RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes
McDermott, B., Ellis, S., Bou-Gharios, G., Clegg, P., & Tew, S. (2016). RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes. Osteoarthritis and Cartilage, 24(7), 1263-1273. doi:10.1016/j.joca.2016.01.988
Proteomic differences between native and tissue-engineered tendon and ligament
Kharaz, Y. A., Tew, S. R., Peffers, M., Canty-Laird, E. G., & Comerford, E. (2016). Proteomic differences between native and tissue-engineered tendon and ligament. PROTEOMICS, 16(10), 1547-1556. doi:10.1002/pmic.201500459
Modest, transient high-glucose exposure has the potential to alter DNA methylation profiles of musculoskeletal cells and induce DNA damage
Tregilgas, L., Reynard, L., Tew, S., Loughlin, J., Clegg, P., & Canty-Laird, E. (2016). Modest, transient high-glucose exposure has the potential to alter DNA methylation profiles of musculoskeletal cells and induce DNA damage. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A14). Retrieved from https://www.webofscience.com/
2015
PI-3K signalling is a consensus pathway in musculoskeletal de- and re-differentiation
Mueller, A. J., Tew, S. R., Canty-Laird, E. G., & Clegg, P. D. (2015). PI-3K signalling is a consensus pathway in musculoskeletal de- and re-differentiation. In Bone and Joint Journal Vol. 97-B. British Editorial Society of Bone and Joint Surgery. Retrieved from http://www.bjjprocs.boneandjoint.org.uk/content/97-B/SUPP_11/8
Magnetic resonance compositional imaging of articular cartilage: What can we expect in veterinary medicine?
Hontoir, F., Clegg, P., Nisolle, J. -F., Tew, S., & Vandeweerd, J. -M. (2015). Magnetic resonance compositional imaging of articular cartilage: What can we expect in veterinary medicine?. VETERINARY JOURNAL, 205(1), 11-20. doi:10.1016/j.tvjl.2015.04.035
The effects of adiopokines on canine cruciate ligament and meniscus
Saengsoi, W., Tew, S., Janssens, B., Bing, C., Comerford, E., & German, A. (2015). The effects of adiopokines on canine cruciate ligament and meniscus. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 96(2), A19. Retrieved from https://www.webofscience.com/
2014
Transcriptome‐Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes
Tew, S., McDermott, B., Fentem, R. B., Peffers, M., & Clegg, P. (2014). Transcriptome‐Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes. Arthritis and Rheumatology, 66(11), 3052-3061. doi:10.1002/art.38849
Identifying key proteoglycans in different regions of canine cranial cruciate ligament
Allaith, M. S., Tew, S., Clegg, P. D., Laird, E., Comerford, E., & Caterson, B. (2014). Identifying key proteoglycans in different regions of canine cranial cruciate ligament. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 95 (pp. A2-A3). Retrieved from https://www.webofscience.com/
A COMPARISON OF THE EXTRACELLULAR MATRIX COMPOSITION OF TENDON/LIGAMENT TISSUE AND TISSUE ENGINEERED TENDON AND LIGAMENT CONSTRUCT
Kharaz, Y. A., Tew, S., Canty-Laird, E., & Comerford, E. (2014). A COMPARISON OF THE EXTRACELLULAR MATRIX COMPOSITION OF TENDON/LIGAMENT TISSUE AND TISSUE ENGINEERED TENDON AND LIGAMENT CONSTRUCT. In OSTEOARTHRITIS AND CARTILAGE Vol. 22 (pp. S313). doi:10.1016/j.joca.2014.02.580
THE IDENTIFICATION AND DISTRIBUTION OF KEY PROTEOGLYCANS IN CANINE CRUCIATE LIGAMENT
Allaith, S., Clegg, P. D., Canty-Laird, E. G., Tew, S., Caterson, B., & Comerford, E. (2014). THE IDENTIFICATION AND DISTRIBUTION OF KEY PROTEOGLYCANS IN CANINE CRUCIATE LIGAMENT. In OSTEOARTHRITIS AND CARTILAGE Vol. 22 (pp. S332-S333). doi:10.1016/j.joca.2014.02.614
BIOCHEMICAL COMPOSITION OF CARTILAGE WITH NATURALLY OCCURRING DEFECTS IN THE OVINE FEMORO-TIBIAL JOINT
Matagne, A., Clegg, P., Tew, S., Kirschvink, N., Gustin, P., Meirlaen, P., . . . Vandeweerd, J. M. (2014). BIOCHEMICAL COMPOSITION OF CARTILAGE WITH NATURALLY OCCURRING DEFECTS IN THE OVINE FEMORO-TIBIAL JOINT. In OSTEOPOROSIS INTERNATIONAL Vol. 25 (pp. S192). Retrieved from https://www.webofscience.com/
Biochemical comparison of the extracellular matrix composition of tendon/ligament tissue and tissue engineered tendon/ligament constructs
Kharaz, A. K. A., Tew, S. R. T., Laird, E. G. L., & Comerford, E. C. (2014). Biochemical comparison of the extracellular matrix composition of tendon/ligament tissue and tissue engineered tendon/ligament constructs. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 95 (pp. A4-A5). Retrieved from https://www.webofscience.com/
2013
TRANSCRIPTOMIC SIGNATURES IN CARTILAGE AGEING
Peffers, M. J., Tew, S. R., & Clegg, P. D. (2013). TRANSCRIPTOMIC SIGNATURES IN CARTILAGE AGEING. In OSTEOARTHRITIS AND CARTILAGE Vol. 21 (pp. S9). doi:10.1016/j.joca.2013.02.040
Myocardial cytokine expression in dogs with systemic and naturally occurring cardiac diseases
Fonfara, S., Hetzel, U., Tew, S. R., Cripps, P., Dukes-McEwan, J., & Clegg, P. D. (2013). Myocardial cytokine expression in dogs with systemic and naturally occurring cardiac diseases. AMERICAN JOURNAL OF VETERINARY RESEARCH, 74(3), 408-416. doi:10.2460/ajvr.74.3.408
Expression of matrix metalloproteinases, their inhibitors, and lysyl oxidase in myocardial samples from dogs with end-stage systemic and cardiac diseases
Fonfara, S., Hetzel, U., Tew, S. R., Cripps, P., Dukes-McEwan, J., & Clegg, P. D. (2013). Expression of matrix metalloproteinases, their inhibitors, and lysyl oxidase in myocardial samples from dogs with end-stage systemic and cardiac diseases. AMERICAN JOURNAL OF VETERINARY RESEARCH, 74(2), 216-223. doi:10.2460/ajvr.74.2.216
CANINE DILATED CARDIOMYOPATHY IS ASSOCIATED WITH INCREASED MYOCARDIAL ICAM1 EXPRESSION
Fonfara, S., Hetzel, U., Oyama, M., Tew, S. R., & Kipar, A. (2013). CANINE DILATED CARDIOMYOPATHY IS ASSOCIATED WITH INCREASED MYOCARDIAL ICAM1 EXPRESSION. In JOURNAL OF COMPARATIVE PATHOLOGY Vol. 148 (pp. 99). doi:10.1016/j.jcpa.2012.11.213
Gene expression alterations in tendon-derived cells after serial passage in 2D cell culture
Mueller, A. J., Tew, S. R., Vasieva, O., Clegg, P. D., & Canty-Laird, E. G. (2013). Gene expression alterations in tendon-derived cells after serial passage in 2D cell culture. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 94 (pp. A4-A5). Retrieved from https://www.webofscience.com/
Investigating the post-transcriptional regulatory mechanisms controlling SOX9 in chondrocytes
McDermott, B. T., Clegg, P. D., & Tew, S. R. (2013). Investigating the post-transcriptional regulatory mechanisms controlling SOX9 in chondrocytes. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 94 (pp. A14-A15). Retrieved from https://www.webofscience.com/
2012
Increased blood mRNA expression of inflammatory and anti-fibrotic markers in dogs with congestive heart failure
Fonfara, S., Tew, S. R., Cripps, P., Dukes-McEwan, J., & Clegg, P. D. (2012). Increased blood mRNA expression of inflammatory and anti-fibrotic markers in dogs with congestive heart failure. RESEARCH IN VETERINARY SCIENCE, 93(2), 879-885. doi:10.1016/j.rvsc.2011.10.020
GLOBAL GENE EXPRESSION ANALYSIS OF DEDIFFERENTIATED CHONDROCYTES
Mueller, A. J., Laird, E. G., Tew, S. R., & Clegg, P. D. (2012). GLOBAL GENE EXPRESSION ANALYSIS OF DEDIFFERENTIATED CHONDROCYTES. In RHEUMATOLOGY Vol. 51 (pp. 49). Retrieved from https://www.webofscience.com/
Fat pad-derived mesenchymal stem cells as a potential source for cell-based adipose tissue repair strategies
Khan, W. S., Adesida, A. B., Tew, S. R., Longo, U. G., & Hardingham, T. E. (2012). Fat pad-derived mesenchymal stem cells as a potential source for cell-based adipose tissue repair strategies. CELL PROLIFERATION, 45(2), 111-120. doi:10.1111/j.1365-2184.2011.00804.x
SUBSTANTIAL ALTERATION OF POST-TRANSCRIPTIONAL GENE CONTROL IN CHONDROCYTES FROM OSTEOARTHRITIC JOINTS
Tew, S. R., McDermott, B., Vasieva, O., & Clegg, P. D. (2012). SUBSTANTIAL ALTERATION OF POST-TRANSCRIPTIONAL GENE CONTROL IN CHONDROCYTES FROM OSTEOARTHRITIC JOINTS. OSTEOARTHRITIS AND CARTILAGE, 20, S43. doi:10.1016/j.joca.2012.02.582
MYOCARDIAL ICAM1 MRNA IS INCREASED IN CANINE DILATED CARDIOMYOPATHY.
Fonfara, S., Oyama, M. A., Cripps, P., Tew, S. R., & Clegg, P. D. (2012). MYOCARDIAL ICAM1 MRNA IS INCREASED IN CANINE DILATED CARDIOMYOPATHY.. JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(3), 716. Retrieved from https://www.webofscience.com/
2011
Leptin Expression in Dogs with Cardiac Disease and Congestive Heart Failure
Fonfara, S., Hetzel, U., Tew, S. R., Dukes-Mcewan, J., Cripps, P., & Clegg, P. D. (2011). Leptin Expression in Dogs with Cardiac Disease and Congestive Heart Failure. JOURNAL OF VETERINARY INTERNAL MEDICINE, 25(5), 1017-1024. doi:10.1111/j.1939-1676.2011.00782.x
Post-transcriptional gene regulation following exposure of osteoarthritic human articular chondrocytes to hyperosmotic conditions
Tew, S. R., Vasieva, O., Peffers, M. J., & Clegg, P. D. (2011). Post-transcriptional gene regulation following exposure of osteoarthritic human articular chondrocytes to hyperosmotic conditions. OSTEOARTHRITIS AND CARTILAGE, 19(8), 1036-1046. doi:10.1016/j.joca.2011.04.015
Analysis of Post Transcriptional Regulation of SOX9 mRNA During <i>In Vitro</i> Chondrogenesis
Tew, S. R., & Clegg, P. D. (2011). Analysis of Post Transcriptional Regulation of SOX9 mRNA During <i>In Vitro</i> Chondrogenesis. TISSUE ENGINEERING PART A, 17(13-14), 1801-1807. doi:10.1089/ten.tea.2010.0579
Development of a luciferase-based reporter system to analyse post-transcriptional gene regulation in osteoarthritis
McDermott, B. T., Tew, S. R., & Clegg, P. D. (2011). Development of a luciferase-based reporter system to analyse post-transcriptional gene regulation in osteoarthritis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 92 (pp. A31-A32). Retrieved from https://www.webofscience.com/
LEPTIN EXPRESSION IN BLOOD AND MYOCARDIAL SAMPLES OF DOGS WITH CARDIAC DISEASE
Fonfara, S., Hetzel, U., Tew, S. R., Dukes-McEwan, J., & Clegg, P. D. (2011). LEPTIN EXPRESSION IN BLOOD AND MYOCARDIAL SAMPLES OF DOGS WITH CARDIAC DISEASE. JOURNAL OF VETERINARY INTERNAL MEDICINE, 25(3), 649-650. Retrieved from https://www.webofscience.com/
Optimisation of osteogenic and chondrogenic differentiation potential using clonal mesenchymal stem cell populations derived from synovial fat pad
Khan, W. S., Tew, S. R., Adesida, A. B., Andrew, J. Q., & Hardingham, T. E. (2011). Optimisation of osteogenic and chondrogenic differentiation potential using clonal mesenchymal stem cell populations derived from synovial fat pad. In European Cells and Materials Vol. 22 (pp. 56).
Regulation of SOX9 mRNA decay correlates with overall SOX9 levels in human articular chondrocytes: evidence for the involvement of the RNA binding protein tristetraprolin
Tew, S. R., & Clegg, P. D. (2011). Regulation of SOX9 mRNA decay correlates with overall SOX9 levels in human articular chondrocytes: evidence for the involvement of the RNA binding protein tristetraprolin. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 92 (pp. A31). Retrieved from https://www.webofscience.com/
2010
Post-transcriptional gene regulation in chondrocytes
Tew, S. R., & Clegg, P. D. (2010). Post-transcriptional gene regulation in chondrocytes. BIOCHEMICAL SOCIETY TRANSACTIONS, 38, 1627-1631. doi:10.1042/BST0381627
Regulation of SOX9 in normal and osteoarthritic equine articular chondrocytes by hyperosmotic loading
Peffers, M. J., Milner, P. I., Tew, S. R., & Clegg, P. D. (2010). Regulation of SOX9 in normal and osteoarthritic equine articular chondrocytes by hyperosmotic loading. OSTEOARTHRITIS AND CARTILAGE, 18(11), 1502-1508. doi:10.1016/j.joca.2010.08.011
CYCLICAL HYPEROSMOLAR LOADING OF HUMAN ARTICULAR CHONDROCYTES INCREASES SOX9 GENE EXPRESSION AND P38 SIGNALLING IS REQUIRED
Peffers, M. J., Clegg, P. D., Tew, S., & Milne, P. I. (2010). CYCLICAL HYPEROSMOLAR LOADING OF HUMAN ARTICULAR CHONDROCYTES INCREASES SOX9 GENE EXPRESSION AND P38 SIGNALLING IS REQUIRED. In OSTEOARTHRITIS AND CARTILAGE Vol. 18 (pp. S125). doi:10.1016/S1063-4584(10)60306-8
IDENTIFICATION OF POST-TRANSCRIPTIONALLY REGULATED GENES FOLLOWING EXPOSURE OF HUMAN ARTICULAR CHONDROCYTES TO HYPEROSMOTIC CONDITIONS
Tew, S. R., & Clegg, P. D. (2010). IDENTIFICATION OF POST-TRANSCRIPTIONALLY REGULATED GENES FOLLOWING EXPOSURE OF HUMAN ARTICULAR CHONDROCYTES TO HYPEROSMOTIC CONDITIONS. In OSTEOARTHRITIS AND CARTILAGE Vol. 18 (pp. S99). doi:10.1016/S1063-4584(10)60237-3
Bone Marrow-Derived Mesenchymal Stem Cells Express the Pericyte Marker 3G5 in Culture and Show Enhanced Chondrogenesis in Hypoxic Conditions
Khan, W. S., Adesida, A. B., Tew, S. R., Lowe, E. T., & Hardingham, T. E. (2010). Bone Marrow-Derived Mesenchymal Stem Cells Express the Pericyte Marker 3G5 in Culture and Show Enhanced Chondrogenesis in Hypoxic Conditions. JOURNAL OF ORTHOPAEDIC RESEARCH, 28(6), 834-840. doi:10.1002/jor.21043
Bone and Cartilage Biology - lessons from development, vascular interactions and dysplasias
Brakspear, K., Culley, K., Davidson, R., Sofat, N., & Tew, S. (2010). Bone and Cartilage Biology - lessons from development, vascular interactions and dysplasias. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 91 (pp. A1-A14). Retrieved from https://www.webofscience.com/
CYTOKINE AND MATRIX METALLOPROTEINASE EXPRESSION IN BLOOD SAMPLES OF DOGS WITH CONGESTIVE HEART FAILURE
Fonfara, S., Tew, S., Clegg, P., & Dukes-McEwan, J. (2010). CYTOKINE AND MATRIX METALLOPROTEINASE EXPRESSION IN BLOOD SAMPLES OF DOGS WITH CONGESTIVE HEART FAILURE. In JOURNAL OF VETERINARY INTERNAL MEDICINE Vol. 24 (pp. 671). Retrieved from https://www.webofscience.com/
Clonal esenchymal stem cell populations derived from the synovial fat pad exhibit a similar cell surface characterisation profile but variable osteogenic and chondrogenic differentiation potential
Khan, W. S., Tew, S. R., Adesida, A., Andrew, J. G., & Hardingham, T. E. (2010). Clonal esenchymal stem cell populations derived from the synovial fat pad exhibit a similar cell surface characterisation profile but variable osteogenic and chondrogenic differentiation potential. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 91 (pp. A19-A20). Retrieved from https://www.webofscience.com/
Hyperosmotic stimulation of chondrocytes leads to differential post transcriptional regulation of SOX9 and COL2A1 mRNA: potential role for the RNA binding proteins TTP and AUF1?
Tew, S. R., & Clegg, P. D. (2010). Hyperosmotic stimulation of chondrocytes leads to differential post transcriptional regulation of SOX9 and COL2A1 mRNA: potential role for the RNA binding proteins TTP and AUF1?. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 91 (pp. A38-A39). Retrieved from https://www.webofscience.com/
The MEK-ERK signalling pathway plays a role in SOX9 gene expression in human articular chondrocytes
Peffers, M. J., Tew, S. R., Milner, P. I., & Clegg, P. D. (2010). The MEK-ERK signalling pathway plays a role in SOX9 gene expression in human articular chondrocytes. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 91 (pp. A38). Retrieved from https://www.webofscience.com/
2009
Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes
Tew, S. R., Peffers, M. J., McKay, T. R., Lowe, E. T., Khan, W. S., Hardingham, T. E., & Clegg, P. D. (2009). Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 297(4), C898-C906. doi:10.1152/ajpcell.00571.2008
The epitope characterisation and the osteogenic differentiation potential of human fat pad-derived stem cells is maintained with ageing in later life
Khan, W. S., Adesida, A. B., Tew, S. K., Andrew, J. G., & Hardingham, T. E. (2009). The epitope characterisation and the osteogenic differentiation potential of human fat pad-derived stem cells is maintained with ageing in later life. INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 40(2), 150-157. doi:10.1016/j.injury.2008.05.029
The influence of donor and hypoxic conditions on the assembly of cartilage matrix by osteoarthritic human articular chondrocytes on Hyalograft matrices
Katopodi, T., Tew, S. R., Clegg, P. D., & Hardingham, T. E. (2009). The influence of donor and hypoxic conditions on the assembly of cartilage matrix by osteoarthritic human articular chondrocytes on Hyalograft matrices. BIOMATERIALS, 30(4), 535-540. doi:10.1016/j.biomaterials.2008.09.064
Rapid stimulation of p38 MAPK and upregulation of SOX9 mRNA following hyperosmotic treatment of human articular chondrocytes
Tew, S. R., Hardingham, T. E., & Clegg, P. D. (2009). Rapid stimulation of p38 MAPK and upregulation of SOX9 mRNA following hyperosmotic treatment of human articular chondrocytes. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 90 (pp. A132). Retrieved from https://www.webofscience.com/
2008
SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription
Tew, S. R., Pothacharoen, P., Katopod, T., & Hardingham, T. E. (2008). SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription. BIOCHEMICAL JOURNAL, 414, 231-236. doi:10.1042/BJ20080262
Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2
Khan, W. S., Tew, S. R., Adesida, A. B., & Hardingham, T. E. (2008). Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2. ARTHRITIS RESEARCH & THERAPY, 10(4). doi:10.1186/ar2448
BSMB Autumn 2007 meeting report - Shaping and sensing the extracellular matrix
Kuiper, N., Gabriel, N., Griffiths, S., & Tew, S. (2008). BSMB Autumn 2007 meeting report - Shaping and sensing the extracellular matrix. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 89(3), A1-A4. doi:10.1111/j.1365-2613.2007.00572.x
Cellular methods in cartilage research: Primary human chondrocytes in culture and chondrogenesis in human bone marrow stem cells
Tew, S. R., Murdoch, A. D., Rauchenberg, R. P., & Hardingham, T. E. (2008). Cellular methods in cartilage research: Primary human chondrocytes in culture and chondrogenesis in human bone marrow stem cells. METHODS, 45(1), 2-9. doi:10.1016/j.ymeth.2008.01.006
Notch signaling through jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis
Oldershaw, R. A., Tew, S. R., Russell, A. M., Meade, K., Hawkins, R., McKay, T. R., . . . Hardingham, T. E. (2008). Notch signaling through jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis. STEM CELLS, 26(3), 666-674. doi:10.1634/stemcells.2007-0806
Bone marrow derived mesenchymal stem cells express pericyte markers in culture and show enhanced chondrogenesis in hypoxic conditions
Khan, W. S., Adesida, A. B., Tew, S. R., Andrew, J. G., & Hardingham, T. E. (2008). Bone marrow derived mesenchymal stem cells express pericyte markers in culture and show enhanced chondrogenesis in hypoxic conditions. In CALCIFIED TISSUE INTERNATIONAL Vol. 83 (pp. 17). Retrieved from https://www.webofscience.com/
Osmotic regulation of SOX9 in human articular chondrocytes through p38 MAPK mediated mRNA stabilization
Tew, S. R., Mckay, T., Lowe, E., Clegg, P. D., & Hardingham, T. E. (2008). Osmotic regulation of SOX9 in human articular chondrocytes through p38 MAPK mediated mRNA stabilization. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 89 (pp. A26). Retrieved from https://www.webofscience.com/
Vascular pericytes in human infrapatellar fat pad tissue are candidate adult stem cells
Khan, W. S., Tew, S. R., Adesida, A. B., & Hardingham, T. E. (2008). Vascular pericytes in human infrapatellar fat pad tissue are candidate adult stem cells. Arthritis Res Ther, 10, R74.
2007
SOX9 transduction of a human chondrocytic cell line identifies novel genes regulated in primary human chondrocytes and in osteoarthritis
Tew, S. R., Clegg, P. D., Brew, C. J., Redmond, C. M., & Hardingham, T. E. (2007). SOX9 transduction of a human chondrocytic cell line identifies novel genes regulated in primary human chondrocytes and in osteoarthritis. ARTHRITIS RESEARCH & THERAPY, 9(5). doi:10.1186/ar2311
Cell Culture in Tissue Engineering
Hardingham, T. E., Kielty, C. M., Canfield, A. E., Tew, S. R., Ball, S. G., Turner, N. J., & Ratcliffe, K. E. (2007). Cell Culture in Tissue Engineering. In Unknown Book (pp. 523-541). Wiley. doi:10.1002/9780470723791.ch28
Tissue regeneration: Formation and repair of the extracellular matrix
Hardingham, T., Tew, S., & Murdoch, A. (2007). Tissue regeneration: Formation and repair of the extracellular matrix. The Biochemist, 29(1), 16-18. doi:10.1042/bio02901016
Cell culture in tissue engineering
Hardingham, T. E., Kielty, C. M., Canfield, A. E., Tew, S. R., Ball, S. G., Turner, N. J., & Ratcliffe, K. E. (2007). Cell culture in tissue engineering. In G. Stacey, & J. Davis (Eds.), Biological Medicines from Cell Culture (pp. 525-543). London: John Wiley and Sons.
In situ detection of cell death in articular cartilage.
Redman, S. N., Khan, I. M., Tew, S. R., & Archer, C. W. (2007). In situ detection of cell death in articular cartilage.. Methods in molecular medicine, 135, 183-199. doi:10.1007/978-1-59745-401-8_11
Interleukin 1β activation of p38 MAPK in human osteoarthritic articular chondrocytes increases SOX9 expression and is dependent on cytoskeletal organisation
Tew, S. R., & Hardingham, T. E. (2007). Interleukin 1β activation of p38 MAPK in human osteoarthritic articular chondrocytes increases SOX9 expression and is dependent on cytoskeletal organisation. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 88 (pp. A53-A54). Retrieved from https://www.webofscience.com/
2006
Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization
Tew, S. R., & Hardingham, T. E. (2006). Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(51), 39471-39479. doi:10.1074/jbc.M604322200
Cartilage, SOX9 and notch signals in chondrogenesis
Hardingham, T. E., Oldershaw, R. A., & Tew, S. R. (2006). Cartilage, SOX9 and notch signals in chondrogenesis. JOURNAL OF ANATOMY, 209(4), 469-480. doi:10.1111/j.1469-7580.2006.00630.x
Control of chondrogenesis and the assembly of cartilage matrix
Hardingham, T., Tew, S., Oldershaw, R., & Murdoch, A. (2006). Control of chondrogenesis and the assembly of cartilage matrix. In JOURNAL OF ANATOMY Vol. 209 (pp. 573). Retrieved from https://www.webofscience.com/
SOX9 can be superinduced by cycloheximide during the early stages of human articular chondrocyte redifferentiation by a p38 MAPK-dependent mechanism
Tew, S. R., & Hardingham, T. E. (2006). SOX9 can be superinduced by cycloheximide during the early stages of human articular chondrocyte redifferentiation by a p38 MAPK-dependent mechanism. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 87 (pp. A54-A55). Retrieved from https://www.webofscience.com/
2005
Co-expression of SOX 9 and SOX 6 enhances collagen 2 gene expression
Lunj, S., Duxbury, R., Russell, A. M., Li, Y., Tew, S. R., Hardingham, T. E., . . . Hawkins, R. E. (2005). Co-expression of SOX 9 and SOX 6 enhances collagen 2 gene expression. European Cells and Materials, 10(SUPPL.2), 52.
British Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK
British Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK (2005). In International Journal of Experimental Pathology Vol. 86. Wiley. doi:10.1111/j.0959-9673.2005.00426.x
Microarray analysis of SOX9-transduced chondrocytic cells identifies genes that are regulated in osteoarthritis
Tew, S. R., Clegg, P. D., Brew, C. J., & Hardingham, T. E. (2005). Microarray analysis of SOX9-transduced chondrocytic cells identifies genes that are regulated in osteoarthritis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 86 (pp. A86-A87). Retrieved from https://www.webofscience.com/
Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes
Tew, S. R., Li, Y., Pothacharoen, P., Tweats, L. M., Hawkins, R. E., & Hardingham, T. E. (2005). Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes. OSTEOARTHRITIS AND CARTILAGE, 13(1), 80-89. doi:10.1016/j.joca.2004.10.011
Stimulation of cartilage matrix synthesis by human articular chondrocytes using SOX9 transfection and hypoxic culture conditions
Tew, S. R., Li, Y., Tweats, L. M., Hawkins, R. E., & Hardingham, T. E. (2005). Stimulation of cartilage matrix synthesis by human articular chondrocytes using SOX9 transfection and hypoxic culture conditions. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 86 (pp. A5-A6). Retrieved from https://www.webofscience.com/
2004
Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9
Li, Y., Tew, S. R., Russell, A. M., Gonzalez, K. R., Hardingham, T. E., & Hawkins, R. E. (2004). Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9. TISSUE ENGINEERING, 10(3-4), 575-584. doi:10.1089/107632704323061933
Transduction of human articular chondrocytes with adenoviral, retroviral and lentiviral vectors and the effects of enhanced expression of SOX9
Li, Y., Tew, S. R., Russell, A. M., Gonzalez, K., Hardingham, T. E., & Hawkins, R. E. (2004). Transduction of human articular chondrocytes with adenoviral, retroviral and lentiviral vectors and the effects of enhanced expression of SOX9. Tissue Engineering, 10, 375-384.
2003
SOX9 transduction and TGFβ-3 treatment of late passage human articular chondrocytes in pellet culture potentiates cartilage matrix formation
Tew, S. R., Li, Y., Tweats, L. M., Katopodi, T., Hawkins, R. E., & Hardingham, T. E. (2003). SOX9 transduction and TGFβ-3 treatment of late passage human articular chondrocytes in pellet culture potentiates cartilage matrix formation. In European Cells and Materials Vol. 6 (pp. 53).
2002
Efficient transduction of human chondrocytes with retroviral, lentiviral and adenoviral vectors
Li, Y., Russell, A. M., Tew, S. R., Hardingham, T. E., & Hawkins, R. E. (2002). Efficient transduction of human chondrocytes with retroviral, lentiviral and adenoviral vectors. In Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products (pp. 103).
Enhanced chondrocyte redifferentiation after SOX9 transduction
Tew, S. R., Li, Y., Russell, A., Prince, J. M., Hawkins, R., & Hardingham, T. E. (2002). Enhanced chondrocyte redifferentiation after SOX9 transduction. In Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products (pp. 48).
The re-expression of chondrocytic phenotype by passaged human articular chondrocytes is improved by viral transduction of SOX9
Tew, S. R., Li, Y., Russell, A. M., Prince, J. M., Hawkins, R. E., & Hardingham, T. E. (2002). The re-expression of chondrocytic phenotype by passaged human articular chondrocytes is improved by viral transduction of SOX9. In European Cells and Materials Vol. 4 (pp. 88).
Tissue engineering: chondrocytes and cartilage
Hardingham, T., Tew, S., & Murdoch, A. (2002). Tissue engineering: chondrocytes and cartilage. ARTHRITIS RESEARCH & THERAPY, 4, S63-S68. doi:10.1186/ar561
2001
SOX gene expression and growth factor responses of human chondrocyte cell lines in monolayer culture
Tew, S. R., Goldring, M. B., & Hardingham, T. E. (2001). SOX gene expression and growth factor responses of human chondrocyte cell lines in monolayer culture. In International Journal of Experimental Pathology Vol. 82.
Differences in repair responses between immature and mature cartilage
Tew, S., Redman, S., Kwan, A., Walker, E., Khan, I., Dowthwaite, G., . . . Archer, C. W. (2001). Differences in repair responses between immature and mature cartilage. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, (391), S142-S152. Retrieved from https://www.webofscience.com/
2000
The reactions of articular cartilage to experimental wounding - Role of apoptosis
Tew, S. R., Kwan, A. P. L., Hann, A., Thomson, B. M., & Archer, C. W. (2000). The reactions of articular cartilage to experimental wounding - Role of apoptosis. ARTHRITIS AND RHEUMATISM, 43(1), 215-225. doi:3.0.CO;2-X">10.1002/1529-0131(200001)43:1<215::AID-ANR26>3.0.CO;2-X
The reactions of articular cartilage to experimental wounding: role of apoptosis.
Tew, S. R., Kwan, A. P., Hann, A., Thomson, B. M., & Archer, C. W. (2000). The reactions of articular cartilage to experimental wounding: role of apoptosis.. Arthritis and rheumatism, 43(1), 215-225. doi:3.0.co;2-x">10.1002/1529-0131(200001)43:1<215::aid-anr26>3.0.co;2-x
1998
What can we learn about cartilage repair from development?
Archer, C. W., Francis-West, P., Walker, E. A., & Tew, S. R. (1998). What can we learn about cartilage repair from development?. In J. A. Buckwalter, M. G. Ehrlich, L. J. Sandell, & S. B. Trippel (Eds.), Skeletal Growth and Development (pp. 1-2). Rosemont, IL: American Academy of Orthopaedic Surgeons.
What can we learn about cartilage repair from development?
Archer, C. W., Francis-West, P., Walker, E. A., & Tew, S. R. (1998). What can we learn about cartilage repair from development?. In SKELETAL GROWTH AND DEVELOPMENT: CLINICAL ISSUES AND BASIC SCIENCE ADVANCES (pp. 491-504). Retrieved from https://www.webofscience.com/