2019
A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury. (Journal article)
Cirulli, E. T., Nicoletti, P., Abramson, K., Andrade, R. J., Bjornsson, E. S., Chalasani, N., . . . International DILI consortium (iDILIC). (2019). A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury.. Gastroenterology, 156(6), 1707-1716.e2. doi:10.1053/j.gastro.2019.01.034
DOI: 10.1053/j.gastro.2019.01.034
Controversies in drug allergy: Testing for delayed reactions (Journal article)
Phillips, E. J., Bigliardi, P., Bircher, A. J., Broyles, A., Chang, Y. -S., Chung, W. -H., . . . Barbaud, A. (2019). Controversies in drug allergy: Testing for delayed reactions. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(1), 66-73. doi:10.1016/j.jaci.2018.10.030
DOI: 10.1016/j.jaci.2018.10.030
Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles. (Journal article)
Nicoletti, P., Aithal, G. P., Chamberlain, T. C., Coulthard, S., Alshabeeb, M., Grove, J. I., . . . International Drug-Induced Liver Injury Consortium (iDILIC). (2019). Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles.. Clinical pharmacology and therapeutics. doi:10.1002/cpt.1375
Genome-wide association study of inhaled corticosteroid response in admixed children with asthma. (Journal article)
Hernandez-Pacheco, N., Farzan, N., Francis, B., Karimi, L., Repnik, K., Vijverberg, S. J., . . . Pino-Yanes, M. (2019). Genome-wide association study of inhaled corticosteroid response in admixed children with asthma.. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. doi:10.1111/cea.13354
HLA-DQB1 6672G > C INFLUENCES THE RISK OF CLOZAPINE-INDUCED AGRANULOCYTOSIS IN INDIVIDUALS OF EUROPEAN ANCESTRY (Conference Paper)
Konte, B., Walters, J., Giegling, I., Legge, S., Cohen, D., Pirmohamed, M., . . . Rujescu, D. (2019). HLA-DQB1 6672G > C INFLUENCES THE RISK OF CLOZAPINE-INDUCED AGRANULOCYTOSIS IN INDIVIDUALS OF EUROPEAN ANCESTRY. In EUROPEAN NEUROPSYCHOPHARMACOLOGY Vol. 29 (pp. S866). doi:10.1016/j.euroneuro.2017.08.154
DOI: 10.1016/j.euroneuro.2017.08.154
Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study (Journal article)
Jorgensen, A. L., Prince, C., Fitzgerald, G., Hanson, A., Downing, J., Reynolds, J., . . . Pirmohamed, M. (2019). Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study. BMC MEDICINE, 17. doi:10.1186/s12916-019-1308-7
DOI: 10.1186/s12916-019-1308-7
REPLICATION OF TWO INDEPENDENT LOCI IN HLA-DQB1 AND HLA-B CONTRIBUTING TO THE RISK OF CLOZAPINE-INDUCED AGRANULOCYTOSIS (Conference Paper)
Konte, B., Giegling, I., Legge, S., Cohen, D., Pirmohamed, M., Tiihonen, J., . . . Rujescu, D. (2019). REPLICATION OF TWO INDEPENDENT LOCI IN HLA-DQB1 AND HLA-B CONTRIBUTING TO THE RISK OF CLOZAPINE-INDUCED AGRANULOCYTOSIS. In EUROPEAN NEUROPSYCHOPHARMACOLOGY Vol. 29 (pp. S939). doi:10.1016/j.euroneuro.2017.08.282
DOI: 10.1016/j.euroneuro.2017.08.282
Carr, D. F., Wang, C. -W., Bellón, T., Ressel, L., Nwikue, G., Shrivastava, V., . . . Pirmohamed, M. (2019). Serum and blister-fluid elevation and decreased epidermal content of high-mobility group box 1 protein in drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.. The British journal of dermatology. doi:10.1111/bjd.17610
Software for Dosage Individualization of Voriconazole: a Prospective Clinical Study. (Journal article)
Hope, W., Johnstone, G., Cicconi, S., Felton, T., Goodwin, J., Whalley, S., . . . Neely, M. (2019). Software for Dosage Individualization of Voriconazole: a Prospective Clinical Study.. Antimicrobial agents and chemotherapy. doi:10.1128/aac.02353-18
Giebel, C., McIntyre, J. C., Daras, K., Gabbay, M., Downing, J., Pirmohamed, M., . . . Barr, B. (2019). What are the social predictors of accident and emergency attendance in disadvantaged neighbourhoods? Results from a cross-sectional household health survey in the north west of England.. BMJ open, 9(1), e022820. doi:10.1136/bmjopen-2018-022820
DOI: 10.1136/bmjopen-2018-022820
Working together to deliver stratified medicine research effectively (Journal article)
Attar, S. G., Poustie, V. J., Hawcutt, D. B., Oni, L., Beresford, M. W., & Pirmohamed, M. (2019). Working together to deliver stratified medicine research effectively. British Medical Bulletin. doi:10.1093/bmb/ldz003
Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers. (Journal article)
Alhilali, K. A., Al-Attar, Z., Gibson, A., Tailor, A., Meng, X., Monshouwer, M., . . . Naisbitt, D. J. (2019). Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers.. Toxicological sciences : an official journal of the Society of Toxicology, 168(2), 597-609. doi:10.1093/toxsci/kfz007
Aspirin nonresponsiveness in pregnant women at high risk of pre-eclampsia (Conference Paper)
Navaratnam, K., Agarwal, U., Alfirevic, A., & Alfirevic, Z. (2019). Aspirin nonresponsiveness in pregnant women at high risk of pre-eclampsia. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 126 (pp. 4).
Evaluation of agreement of placental growth factor (PlGF) tests and the soluble FMS-like tyrosine kinase 1 (sFlt-1)/PlGF ratio, comparison of predictive accuracy for pre-eclampsia, and relation to uterine artery Doppler and response to aspirin (Journal article)
Navaratnam, K., Abreu, P., Clarke, H., Jorgensen, A., Alfirevic, A., & Alfirevic, Z. (2019). Evaluation of agreement of placental growth factor (PlGF) tests and the soluble FMS-like tyrosine kinase 1 (sFlt-1)/PlGF ratio, comparison of predictive accuracy for pre-eclampsia, and relation to uterine artery Doppler and response to aspirin. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 32(2), 179-187. doi:10.1080/14767058.2017.1373760
DOI: 10.1080/14767058.2017.1373760
Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study (Journal article)
Jorgensen, A. L., Prince, C., Fitzgerald, G., Hanson, A., Downing, J., Reynolds, J., . . . Pirmohamed, M. (2019). Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study. BMC MEDICINE, 17. doi:10.1186/s12916-019-1308-7
DOI: 10.1186/s12916-019-1308-7
What are the social predictors of accident and emergency attendance in disadvantaged neighbourhoods? Results from a cross-sectional household health survey in the north west of England. (Journal article)
Giebel, C., McIntyre, J. C., Daras, K., Gabbay, M., Downing, J., Pirmohamed, M., . . . Barr, B. (2019). What are the social predictors of accident and emergency attendance in disadvantaged neighbourhoods? Results from a cross-sectional household health survey in the north west of England.. BMJ open, 9(1), e022820. doi:10.1136/bmjopen-2018-022820
DOI: 10.1136/bmjopen-2018-022820
CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program. (Journal article)
Thaventhiran, T., Wong, W., Alghanem, A. F., Alhumeed, N., Aljasir, M. A., Ramsey, S., . . . Sathish, J. G. (2019). CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program.. Monoclonal antibodies in immunodiagnosis and immunotherapy, 38(2), 60-69. doi:10.1089/mab.2018.0042
Modelling changes in glutathione homeostasis as a function of quinone redox metabolism. (Journal article)
Kelly, R. A., Leedale, J., Calleja, D., Enoch, S. J., Harrell, A., Chadwick, A. E., & Webb, S. (2019). Modelling changes in glutathione homeostasis as a function of quinone redox metabolism.. Scientific reports, 9(1), 6333. doi:10.1038/s41598-019-42799-2
DOI: 10.1038/s41598-019-42799-2
SFX-01 reduces residual disability after experimental autoimmune encephalomyelitis. (Journal article)
Galea, I., Copple, I. M., Howat, D. W., & Franklin, S. (2019). SFX-01 reduces residual disability after experimental autoimmune encephalomyelitis.. Multiple sclerosis and related disorders, 30, 257-261. doi:10.1016/j.msard.2019.02.027
DOI: 10.1016/j.msard.2019.02.027
Developing a 3D intestinal epithelium model for livestock species (Journal article)
Derricott, H., Luu, L., Fong, W. Y., Hartley, C. S., Johnston, L. J., Armstrong, S. D., . . . Coombes, J. L. (2019). Developing a 3D intestinal epithelium model for livestock species. CELL AND TISSUE RESEARCH, 375(2), 409-424. doi:10.1007/s00441-018-2924-9
DOI: 10.1007/s00441-018-2924-9
Stem cell models as an in vitro model for predictive toxicology. (Journal article)
Lynch, S., Pridgeon, C. S., Duckworth, C. A., Sharma, P., Park, B. K., & Goldring, C. E. P. (2019). Stem cell models as an in vitro model for predictive toxicology.. The Biochemical journal, 476(7), 1149-1158. doi:10.1042/bcj20170780
Dapsone- and nitroso dapsone-specific activation of T cells from hypersensitive patients expressing the risk allele HLA-B*13:01. (Journal article)
Zhao, Q., Alhilali, K., Alzahrani, A., Almutairi, M., Amjad, J., Liu, H., . . . Naisbitt, D. J. (2019). Dapsone- and nitroso dapsone-specific activation of T cells from hypersensitive patients expressing the risk allele HLA-B*13:01.. Allergy. doi:10.1111/all.13769
Attenuation of doxorubicin-induced cardiotoxicity in a human in vitro cardiac model by the induction of the NRF-2 pathway (Journal article)
Tomlinison, L., Lu, Z. Q., Bentley, R., Colley, H., Murdoch, C., Webb, S., . . . Sharma, P. (n.d.). Attenuation of doxorubicin-induced cardiotoxicity in a human in vitro cardiac model by the induction of the NRF-2 pathway. Biomedicine and Pharmacotherapy. doi:10.1016/j.biopha.2019.108637
DOI: 10.1016/j.biopha.2019.108637
Characterisation of a functional rat hepatocyte spheroid model (Journal article)
Kyffin, J. A., Sharma, P., Leedale, J., Colley, H. E., Murdoch, C., Harding, A. L., . . . Webb, S. D. (2019). Characterisation of a functional rat hepatocyte spheroid model. TOXICOLOGY IN VITRO, 55, 160-172. doi:10.1016/j.tiv.2018.12.014
DOI: 10.1016/j.tiv.2018.12.014
In vitro Liver Zonation of Primary Rat Hepatocytes (Journal article)
Tomlinson, L., Hyndman, L., Firman, J. W., Bentley, R., Kyffin, J. A., Webb, S. D., . . . Sharma, P. (2019). In vitro Liver Zonation of Primary Rat Hepatocytes. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 7. doi:10.3389/fbioe.2019.00017
Characterization Of Amoxicillin- And Clavulanic Acid-Specific T-Cells In Patients With Amoxicillin-Clavulanic Acid Hypersensitivity Reactions (Conference Paper)
Ariza, A., Isabel Montanez, M., Ogese, M. O., Tailor, A., Fernandez, T. D., Torres, M. J., & Naisbitt, D. J. (2019). Characterization Of Amoxicillin- And Clavulanic Acid-Specific T-Cells In Patients With Amoxicillin-Clavulanic Acid Hypersensitivity Reactions. In JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Vol. 143 (pp. AB184). doi:10.1016/j.jaci.2018.12.563