2013

 

A cellular automaton model examining the effects of oxygen, hydrogen ions and lactate on early tumour growth (Journal article)

Al-Husari, M., Murdoch, C., & Webb, S. D. (2014). A cellular automaton model examining the effects of oxygen, hydrogen ions and lactate on early tumour growth. Journal of Mathematical Biology, 69(4), 839-873. doi:10.1007/s00285-013-0719-x

DOI: 10.1007/s00285-013-0719-x

 

A Flexible Mathematical Model Platform for Studying Branching Networks: Experimentally Validated Using the Model Actinomycete, Streptomyces coelicolor (Journal article)

Nieminen, L., Webb, S., Smith, M. C. M., & Hoskisson, P. A. (2013). A Flexible Mathematical Model Platform for Studying Branching Networks: Experimentally Validated Using the Model Actinomycete, Streptomyces coelicolor. PLoS ONE, 8(2), e54316. doi:10.1371/journal.pone.0054316

DOI: 10.1371/journal.pone.0054316

 

A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy (Journal article)

Speed, D., Hoggart, C., Petrovski, S., Tachmazidou, I., Coffey, A., Jorgensen, A., . . . Johnson, M. R. (2014). A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. Human Molecular Genetics, 23(1), 247-258. doi:10.1093/hmg/ddt403

DOI: 10.1093/hmg/ddt403

 

A microRNA-based prediction algorithm for diagnosis of non-small lung cell carcinoma in minimal biopsy material (Journal article)

Bediaga, N. G., Davies, M. P. A., Acha-Sagredo, A., Hyde, R., Raji, O. Y., Page, R., . . . Liloglou, T. (2013). A microRNA-based prediction algorithm for diagnosis of non-small lung cell carcinoma in minimal biopsy material. BRITISH JOURNAL OF CANCER, 109(9), 2404-2411. doi:10.1038/bjc.2013.623

DOI: 10.1038/bjc.2013.623

 

A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide (Journal article)

Williams, J. M., Duckworth, C. A., Watson, A. J. M., Frey, M. R., Miguel, J. C., Burkitt, M. D., . . . Pritchard, D. M. (2013). A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide. DISEASE MODELS & MECHANISMS, 6(6), 1388-1399. doi:10.1242/dmm.013284

DOI: 10.1242/dmm.013284

 

A multi-system approach assessing the interaction of anticonvulsants with P-gp. (Journal article)

Dickens, D., Yusof, S. R., Abbott, N. J., Weksler, B., Romero, I. A., Couraud, P. -O., . . . Owen, A. (2013). A multi-system approach assessing the interaction of anticonvulsants with P-gp.. PloS One, 8(5), e64854.

 

A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp (Journal article)

Dickens, D., Yusof, S. R., Abbott, N. J., Weksler, B., Romero, I. A., Couraud, P. -O., . . . Owen, A. (2013). A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp. PLOS ONE, 8(5). doi:10.1371/journal.pone.0064854

DOI: 10.1371/journal.pone.0064854

 

A Randomized Trial of Genotype-Guided Dosing of Acenocoumarol and Phenprocoumon (Journal article)

Verhoef, T. I., Ragia, G., de Boer, A., Barallon, R., Kolovou, G., Kolovou, V., . . . Grp, E. U. -P. A. C. T. (2013). A Randomized Trial of Genotype-Guided Dosing of Acenocoumarol and Phenprocoumon. NEW ENGLAND JOURNAL OF MEDICINE, 369(24), 2304-2312. doi:10.1056/NEJMoa1311388

DOI: 10.1056/NEJMoa1311388

 

A Randomized Trial of Genotype-Guided Dosing of Warfarin (Journal article)

Pirmohamed, M., Burnside, G., Eriksson, N., Jorgensen, A. L., Toh, C. H., Nicholson, T., . . . Grp, E. U. -P. A. C. T. (2013). A Randomized Trial of Genotype-Guided Dosing of Warfarin. NEW ENGLAND JOURNAL OF MEDICINE, 369(24), 2294-2303. doi:10.1056/NEJMoa1311386

DOI: 10.1056/NEJMoa1311386

 

A Randomized Trial of Genotype-Guided Dosing of Warfarin (Journal article)

Pirmohamed, M., Burnside, G., Eriksson, N., Jorgensen, A. L., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial of Genotype-Guided Dosing of Warfarin. New England Journal of Medicine, 369(24), 2294-2303. doi:10.1056/NEJMoa1311386

DOI: 10.1056/NEJMoa1311386

 

A theoretical study of the role of spatial population structure in the evolution of parasite virulence (Journal article)

Webb, S. D., Keeling, M. J., & Boots, M. (2013). A theoretical study of the role of spatial population structure in the evolution of parasite virulence. Theoretical Population Biology, 84, 36-45. doi:10.1016/j.tpb.2012.11.008

 

ABCB1 single nucleotide polymorphisms (1236C > T, 2677G > T, and 3435C > T) do not affect transport activity of human P-glycoprotein (Journal article)

Dickens, D., Owen, A., Alfirevic, A., & Pirmohamed, M. (2013). ABCB1 single nucleotide polymorphisms (1236C > T, 2677G > T, and 3435C > T) do not affect transport activity of human P-glycoprotein. PHARMACOGENETICS AND GENOMICS, 23(6), 314-323. doi:10.1097/FPC.0b013e328360d10c

DOI: 10.1097/FPC.0b013e328360d10c

 

Acid-mediated tumour cell invasion: a discrete modelling approach using the extended Potts model (Journal article)

Al-Husari, M., & Webb, S. D. (2013). Acid-mediated tumour cell invasion: a discrete modelling approach using the extended Potts model. Clinical & Experimental Metastasis, 30(6), 793-806. doi:10.1007/s10585-013-9579-4

DOI: 10.1007/s10585-013-9579-4

 

Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives (Journal article)

Farrell, J., Lichtenfels, M., Sullivan, A., Elliott, E. C., Alfirevic, A., Stachulski, A. V., . . . Park, B. K. (2013). Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(2), 493-495. doi:10.1016/j.jaci.2013.02.045

DOI: 10.1016/j.jaci.2013.02.045

 

Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives (Journal article)

Farrell, J., Lichtenfels, M., Sullivan, A., Elliott, E. C., Alfirevic, A., Stachulski, A. V., . . . Park, B. K. (2013). Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives. Journal of Allergy and Clinical Immunology, 132(2), 493-495. doi:10.1016/j.jaci.2013.02.045

DOI: 10.1016/j.jaci.2013.02.045

 

Adherence and variability in warfarin dose requirements: assessment in a prospective cohort (Journal article)

Jorgensen, A. L., Hughes, D. A., Hanson, A., van Eker, D., Toh, C. H., Pirmohamed, M., & Williamson, P. R. (2013). Adherence and variability in warfarin dose requirements: assessment in a prospective cohort. PHARMACOGENOMICS, 14(2), 151-163. doi:10.2217/PGS.12.199

DOI: 10.2217/PGS.12.199

 

Adverse drug reactions and off-label and unlicensed medicines in children: a nested case-control study of inpatients in a pediatric hospital (Journal article)

Bellis, J. R., Kirkham, J. J., Thiesen, S., Conroy, E. J., Bracken, L. E., Mannix, H. L., . . . Pirmohamed, M. (2013). Adverse drug reactions and off-label and unlicensed medicines in children: a nested case-control study of inpatients in a pediatric hospital. BMC MEDICINE, 11. doi:10.1186/1741-7015-11-238

DOI: 10.1186/1741-7015-11-238

 

Are we closer to finding biomarkers for identifying acute drug-induced liver injury? (Journal article)

Antoine, D. J., Lewis, P. S., Goldring, C. E., & Park, B. K. (2013). Are we closer to finding biomarkers for identifying acute drug-induced liver injury?. Biomarkers in Medicine, 7(3), 383-386. doi:10.2217/bmm.13.42

DOI: 10.2217/bmm.13.42

 

Anticonvulsant agents (Chapter)

Pirmohamed, M., & Leeder, J. S. (2013). Anticonvulsant agents. In Drug-Induced Liver Disease (pp. 423-441). doi:10.1016/B978-0-12-387817-5.00024-8

DOI: 10.1016/B978-0-12-387817-5.00024-8

 

Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation (Journal article)

La Pensee, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A. E., . . . O'Neill, P. M. (2013). Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation. CHEMMEDCHEM, 8(5), 709-718. doi:10.1002/cmdc.201200536

DOI: 10.1002/cmdc.201200536

 

Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population (Journal article)

Carr, D. F., Chaponda, M., Jorgensen, A. L., Castro, E. C., van Oosterhout, J. J., Khoo, S. H., . . . Pirmohamed, M. (2013). Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population. CLINICAL INFECTIOUS DISEASES, 56(9), 1330-1339. doi:10.1093/cid/cit021

DOI: 10.1093/cid/cit021

 

CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia (Journal article)

Johnson, G. G., Lin, K., Cox, T. F., Oates, M., Sibson, D. R., Eccles, R., . . . Pettitt, A. R. (2013). CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia. BLOOD, 122(26), 4253-4258. doi:10.1182/blood-2013-07-516666

DOI: 10.1182/blood-2013-07-516666

 

CYP2C19*17 Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease (Journal article)

Musumba, C. O., Jorgensen, A., Sutton, L., Van Eker, D., Zhang, E., O'Hara, N., . . . Pirmohamed, M. (2013). CYP2C19*17 Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease. CLINICAL PHARMACOLOGY & THERAPEUTICS, 93(2), 195-203. doi:10.1038/clpt.2012.215

DOI: 10.1038/clpt.2012.215

 

Challenges and approaches for the development of safer immunomodulatory biologics (Journal article)

Sathish, J. G., Sethu, S., Bielsky, M. -C., de Haan, L., French, N. S., Govindappa, K., . . . Park, B. K. (2013). Challenges and approaches for the development of safer immunomodulatory biologics. NATURE REVIEWS DRUG DISCOVERY, 12(4), 306-324. doi:10.1038/nrd3974

DOI: 10.1038/nrd3974

 

Characterization of the B cell response in piperacillin hypersensitive patients with cystic fibrosis (Conference Paper)

Amali, M., Sullivan, A., Yaseen, F. S., Farrell, J., Faulkner, L., Whitaker, P., . . . Naisbitt, D. J. (2013). Characterization of the B cell response in piperacillin hypersensitive patients with cystic fibrosis. In IMMUNOLOGY Vol. 140 (pp. 192). Retrieved from http://gateway.webofknowledge.com/

 

Chemotherapy induced hepatotoxicity in metastatic colorectal cancer: A review of mechanisms and outcomes (Journal article)

McWhirter, D., Kitteringham, N., Jones, R. P., Malik, H., Park, K., & Palmer, D. (2013). Chemotherapy induced hepatotoxicity in metastatic colorectal cancer: A review of mechanisms and outcomes. Critical Reviews in Oncology/Hematology, 88(2), 404-415. doi:10.1016/j.critrevonc.2013.05.011

DOI: 10.1016/j.critrevonc.2013.05.011

 

Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Carbamazepine Dosing (Journal article)

Leckband, S. G., Kelsoe, J. R., Dunnenberger, H. M., Jr, G. A. L., Tran, E., Berger, R., . . . Pirmohamed, M. (2013). Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Carbamazepine Dosing. CLINICAL PHARMACOLOGY & THERAPEUTICS, 94(3), 324-328. doi:10.1038/clpt.2013.103

DOI: 10.1038/clpt.2013.103

 

Combined mathematical modelling and experimentation to predict polymersome uptake by oral cancer cells (Journal article)

Sorrell, I., Shipley, R. J., Hearnden, V., Colley, H. E., Thornhill, M. H., Murdoch, C., & Webb, S. D. (2014). Combined mathematical modelling and experimentation to predict polymersome uptake by oral cancer cells. Nanomedicine: Nanotechnology, Biology and Medicine, 10(2), 339-348. doi:10.1016/j.nano.2013.08.013

DOI: 10.1016/j.nano.2013.08.013

 

Comparative Effectiveness of Dabigatran, Rivaroxaban, Apixaban, and Warfarin in the Management of Patients With Nonvalvular Atrial Fibrillation (Journal article)

Pink, J., Pirmohamed, M., & Hughes, D. A. (2013). Comparative Effectiveness of Dabigatran, Rivaroxaban, Apixaban, and Warfarin in the Management of Patients With Nonvalvular Atrial Fibrillation. CLINICAL PHARMACOLOGY & THERAPEUTICS, 94(2), 269-276. doi:10.1038/clpt.2013.83

DOI: 10.1038/clpt.2013.83

 

Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles (Journal article)

Elliott, E. -C., Maggs, J. L., Park, B. K., O'Neill, P. M., & Stachulski, A. V. (2013). Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles. Organic & Biomolecular Chemistry, 11(48), 8426. doi:10.1039/c3ob41252k

DOI: 10.1039/c3ob41252k

 

Correlates of Efavirenz Exposure in Chilean Patients Affected With Human Immunodeficiency Virus Reveals a Novel Association With a Polymorphism in the Constitutive Androstane Receptor (Journal article)

Cortes, C. P., Siccardi, M., Chaikan, A., Owen, A., Zhang, G., & la Porte, C. J. L. (2013). Correlates of Efavirenz Exposure in Chilean Patients Affected With Human Immunodeficiency Virus Reveals a Novel Association With a Polymorphism in the Constitutive Androstane Receptor. THERAPEUTIC DRUG MONITORING, 35(1), 78-83. doi:10.1097/FTD.0b013e318274197e

DOI: 10.1097/FTD.0b013e318274197e

 

Cost-effectiveness of pharmacogenetic-guided dosing of phenprocoumon in atrial fibrillation (Journal article)

Verhoef, T. I., Redekop, W. K., Veenstra, D. L., Thariani, R., Beltman, P. A., van Schie, R. M. F., . . . Grp, E. U. -P. A. C. T. (2013). Cost-effectiveness of pharmacogenetic-guided dosing of phenprocoumon in atrial fibrillation. PHARMACOGENOMICS, 14(8), 869-883. doi:10.2217/PGS.13.74

DOI: 10.2217/PGS.13.74

 

Definition of the mechanistic basis immunological drug reactions using human cells (Conference Paper)

Naisbitt, D. J. (2013). Definition of the mechanistic basis immunological drug reactions using human cells. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 246. Retrieved from http://gateway.webofknowledge.com/

 

Deletion of Specific NF kappa B Proteins Regulates Susceptibility to Developing Colitis Associated Cancer in C57BL/6 Mice As a Result of Altered Inflammatory and DNA Damage Responses (Journal article)

Hanedi, A., Burkitt, M. D., Williams, J. M., Duckworth, C. A., Caamano, J., & Pritchard, D. M. (2013). Deletion of Specific NF kappa B Proteins Regulates Susceptibility to Developing Colitis Associated Cancer in C57BL/6 Mice As a Result of Altered Inflammatory and DNA Damage Responses. Gastroenterology, 144, S136

 

Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients (Journal article)

Meng, X., Howarth, A., Earnshaw, C. J., Jenkins, R. E., French, N. S., Back, D. J., . . . Park, B. K. (2013). Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 26(4), 575-583. doi:10.1021/tx4000107

DOI: 10.1021/tx4000107

 

DRUG-GRAPEFRUIT JUICE INTERACTIONS A more balanced approach to drug-grapefruit juice interactions Reply (Journal article)

Pirmohamed, M. (2013). DRUG-GRAPEFRUIT JUICE INTERACTIONS A more balanced approach to drug-grapefruit juice interactions Reply. BMJ-BRITISH MEDICAL JOURNAL, 346. doi:10.1136/bmj.f1078

DOI: 10.1136/bmj.f1078

 

Drug-grapefruit juice interactions (Journal article)

Pirmohamed, M. (2013). Drug-grapefruit juice interactions. BMJ-BRITISH MEDICAL JOURNAL, 346. doi:10.1136/bmj.f1

DOI: 10.1136/bmj.f1

 

Emergence and global spread of epidemic healthcare-associated Clostridium difficile (Journal article)

He, M., Miyajima, F., Roberts, P., Ellison, L., Pickard, D. J., Martin, M. J., . . . Lawley, T. D. (2013). Emergence and global spread of epidemic healthcare-associated Clostridium difficile. NATURE GENETICS, 45(1), 109-U155. doi:10.1038/ng.2478

DOI: 10.1038/ng.2478

 

Expanding Role of Pharmacogenomics in the Management of Cardiovascular Disorders (Journal article)

Yip, V. L. M., & Pirmohamed, M. (2013). Expanding Role of Pharmacogenomics in the Management of Cardiovascular Disorders. AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS, 13(3), 151-162. doi:10.1007/s40256-013-0024-5

DOI: 10.1007/s40256-013-0024-5

 

Galectins in the blood circulation: potential therapeutic targets of cancer metastasis (Journal article)

Duckworth, C. A., & Yu, L. G. (2013). Galectins in the blood circulation: potential therapeutic targets of cancer metastasis. ACS, 115, 310-322.

 

Genetic testing for prevention of severe drug-induced skin rash (Journal article)

Alfirevic, A., Pirmohamed, M., Marinovic, B., Jorgensen, A. L., & Harcourt-Smith, L. (n.d.). Genetic testing for prevention of severe drug-induced skin rash. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.CD010891

DOI: 10.1002/14651858.CD010891

 

Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study (Journal article)

Jones, R. P., Sutton, P., Greensmith, R. M. D., Santoyo-Castelazo, A., Carr, D. F., Jenkins, R., . . . Kitteringham, N. R. (2013). Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study.. Cancer chemotherapy and pharmacology, 72(2), 359-368. doi:10.1007/s00280-013-2199-5

DOI: 10.1007/s00280-013-2199-5

 

Human Leukocyte Antigen (HLA)-B(star)57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury (Journal article)

Monshi, M. M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2013). Human Leukocyte Antigen (HLA)-B(star)57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 57(2), 727-739. doi:10.1002/hep.26077

DOI: 10.1002/hep.26077

 

Idiosyncratic Adverse Drug Reactions: Current Concepts (Journal article)

Uetrecht, J., & Naisbitt, D. J. (2013). Idiosyncratic Adverse Drug Reactions: Current Concepts. PHARMACOLOGICAL REVIEWS, 65(2), 779-808. doi:10.1124/pr.113.007450

DOI: 10.1124/pr.113.007450

 

Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFN beta interact with the endogenous cytokine and activate complement (Journal article)

Sethu, S., Govindappa, K., Quinn, P., Wadhwa, M., Stebbings, R., Boggild, M., . . . Sathish, J. (2013). Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFN beta interact with the endogenous cytokine and activate complement. CLINICAL IMMUNOLOGY, 148(2), 177-185. doi:10.1016/j.clim.2013.05.008

DOI: 10.1016/j.clim.2013.05.008

 

Immunomodulatory interventions for focal epilepsy syndromes (Journal article)

Walker, L., Pirmohamed, M., & Marson, A. G. (2013). Immunomodulatory interventions for focal epilepsy syndromes. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (6). doi:10.1002/14651858.CD009945.pub2

DOI: 10.1002/14651858.CD009945.pub2

 

Incidence, characteristics and risk factors of adverse drug reactions in hospitalized children - a prospective observational cohort study of 6,601 admissions (Journal article)

Thiesen, S., Conroy, E. J., Bellis, J. R., Bracken, L. E., Mannix, H. L., Bird, K. A., . . . Smyth, R. L. (2013). Incidence, characteristics and risk factors of adverse drug reactions in hospitalized children - a prospective observational cohort study of 6,601 admissions. BMC MEDICINE, 11. doi:10.1186/1741-7015-11-237

DOI: 10.1186/1741-7015-11-237

 

Increased Circulation of Galectin-3 in Cancer Induces Secretion of Metastasis-Promoting Cytokines from Blood Vascular Endothelium (Journal article)

Chen, C., Duckworth, C. A., Zhao, Q., Pritchard, D. M., Rhodes, J. M., & Yu, L. -G. (2013). Increased Circulation of Galectin-3 in Cancer Induces Secretion of Metastasis-Promoting Cytokines from Blood Vascular Endothelium. CLINICAL CANCER RESEARCH, 19(7), 1693-1704. doi:10.1158/1078-0432.CCR-12-2940

DOI: 10.1158/1078-0432.CCR-12-2940

 

Induction of mesenchymal stem cell chondrogenesis by polyacrylate substrates (Journal article)

Glennon-Alty, L., Williams, R., Dixon, S., & Murray, P. (2013). Induction of mesenchymal stem cell chondrogenesis by polyacrylate substrates. ACTA BIOMATERIALIA, 9(4), 6041-6051. doi:10.1016/j.actbio.2012.12.007

DOI: 10.1016/j.actbio.2012.12.007

 

Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers (Journal article)

Pellegrini, G., Starkey Lewis, P. J., Palmer, L., Hetzel, U., Goldring, C. E., Park, B. K., . . . Williams, D. P. (2013). Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers. Toxicology, 314(2-3), 262-266. doi:10.1016/j.tox.2013.06.003

DOI: 10.1016/j.tox.2013.06.003

 

Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality (Journal article)

Crish, J., Conti, M. A., Sakai, T., Adelstein, R. S., & Egelhoff, T. T. (2013). Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality. Developmental Biology, 382(1), 136-148. doi:10.1016/j.ydbio.2013.07.017

DOI: 10.1016/j.ydbio.2013.07.017

 

Lipopolysaccharide Induces Small Intestinal Epithelial Cell Apoptosis and Shedding by a TLR4 and TNFR1 Dependent Mechanism, Which Is Regulated by NF kappa B Signalling (Journal article)

Williams, J. M., Duckworth, C. A., Campbell, B. J., Frey, M. R., Miguel, J. C., Burkitt, M. D., . . . Pritchard, D. M. (2013). Lipopolysaccharide Induces Small Intestinal Epithelial Cell Apoptosis and Shedding by a TLR4 and TNFR1 Dependent Mechanism, Which Is Regulated by NF kappa B Signalling. Gastroenterology, 144, S668.

 

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital (Journal article)

Antoine, D. J., Dear, J. W., Lewis, P. S., Platt, V., Coyle, J., Masson, M., . . . Park, B. K. (2013). Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology, 58(2), 777-787. doi:10.1002/hep.26294

DOI: 10.1002/hep.26294

 

Micrometer Scale Guidance of Mesenchymal Stem Cells to Form Structurally Oriented Cartilage Extracellular Matrix (Journal article)

Chou, C. -L., Rivera, A. L., Sakai, T., Caplan, A. I., Goldberg, V. M., Welter, J. F., & Baskaran, H. (2013). Micrometer Scale Guidance of Mesenchymal Stem Cells to Form Structurally Oriented Cartilage Extracellular Matrix. Tissue Engineering Part A, 19(9-10), 1081-1090. doi:10.1089/ten.tea.2012.0177

DOI: 10.1089/ten.tea.2012.0177

 

Nanomedicines for HIV therapy (Journal article)

Siccardi, M., Martin, P., McDonald, T. O., Liptrott, N. J., Giardiello, M., Rannard, S., & Owen, A. (2013). Nanomedicines for HIV therapy.. Therapeutic delivery, 4(2), 153-156. doi:10.4155/tde.12.156

DOI: 10.4155/tde.12.156

 

Negative regulation by PD-L1 during drug-specific priming of IL-22 secreting T-cells and the influence of PD-1 on effector T-cell function (Conference Paper)

Ogese, M. O., Gibson, A., Sullivan, A., Wang, E., Saide, K., Whitaker, P., . . . Naisbitt, D. (2013). Negative regulation by PD-L1 during drug-specific priming of IL-22 secreting T-cells and the influence of PD-1 on effector T-cell function. In IMMUNOLOGY Vol. 140 (pp. 206). Retrieved from http://gateway.webofknowledge.com/

 

Novel in vitro and mathematical models for the prediction of chemical toxicity (Journal article)

Williams, D. P., Shipley, R., Ellis, M. J., Webb, S., Ward, J., Gardner, I., & Creton, S. (2013). Novel in vitro and mathematical models for the prediction of chemical toxicity. Toxicol. Res., 2(1), 40-59. doi:10.1039/C2TX20031G

DOI: 10.1039/C2TX20031G

 

 

Nuclear Factor-erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Modulates Dendritic Cell Immune Function through Regulation of p38 MAPK-cAMP-responsive Element Binding Protein/Activating Transcription Factor 1 Signaling (Journal article)

Al-Huseini, L. M. A., Aw Yeang, H. X., Sethu, S., Alhumeed, N., Hamdam, J. M., Tingle, Y., . . . Sathish, J. G. (2013). Nuclear Factor-erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Modulates Dendritic Cell Immune Function through Regulation of p38 MAPK-cAMP-responsive Element Binding Protein/Activating Transcription Factor 1 Signaling. Journal of Biological Chemistry, 288(31), 22281-22288. doi:10.1074/jbc.M113.483420

DOI: 10.1074/jbc.M113.483420

 

Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone (Journal article)

Preston, A. J., Keenan, C. M., Sutherland, H., Wilson, P. J., Wlodarski, B., Taylor, A. M., . . . Jarvis, J. C. (2014). Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone. ANNALS OF THE RHEUMATIC DISEASES, 73(1), 284-289. doi:10.1136/annrheumdis-2012-202878

DOI: 10.1136/annrheumdis-2012-202878

  

Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells (Journal article)

Bell, C. C., Castelazo, A. S., Yang, E. L., Maggs, J. L., Jeankins, R. E., Tugwood, J., . . . Park, B. K. (2013). Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells. CHEMICAL RESEARCH IN TOXICOLOGY, 26(7), 1064-1072. doi:10.1021/tx400041v

DOI: 10.1021/tx400041v

 

Paediatric pharmacogenomics: an overview (Journal article)

Hawcutt, D. B., Thompson, B., Smyth, R. L., & Pirmohamed, M. (2013). Paediatric pharmacogenomics: an overview. ARCHIVES OF DISEASE IN CHILDHOOD, 98(3), 232-237. doi:10.1136/archdischild-2012-302852

DOI: 10.1136/archdischild-2012-302852

 

Paediatric use of mycophenolate mofetil (Journal article)

Downing, H. J., Pirmohamed, M., Beresford, M. W., & Smyth, R. L. (2013). Paediatric use of mycophenolate mofetil. British Journal of Clinical Pharmacology, 75(1), 45-59. doi:10.1111/j.1365-2125.2012.04305.x

DOI: 10.1111/j.1365-2125.2012.04305.x

 

Pharmacogenetic tests: the need for a level playing field (Journal article)

Pirmohamed, M., & Hughes, D. A. (2013). Pharmacogenetic tests: the need for a level playing field. NATURE REVIEWS DRUG DISCOVERY, 12(1), 3-4. doi:10.1038/nrd3921

DOI: 10.1038/nrd3921

 

Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity (Journal article)

Pointon, A., Abi-Gerges, N., Cross, M. J., & Sidaway, J. E. (2013). Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity. Toxicological Sciences, 132(2), 317-326. doi:10.1093/toxsci/kft005

DOI: 10.1093/toxsci/kft005

 

Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice (Journal article)

Woolbright, B. L., Antoine, D. J., Jenkins, R. E., Bajt, M. L., Park, B. K., & Jaeschke, H. (2013). Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice. Toxicology and Applied Pharmacology, 273(3), 524-531. doi:10.1016/j.taap.2013.09.023

DOI: 10.1016/j.taap.2013.09.023

 

Population Pharmacokinetic and Pharmacogenetic Analysis of Nevirapine in Hypersensitive and Tolerant HIV-Infected Patients from Malawi (Journal article)

Dickinson, L., Chaponda, M., Carr, D. F., van Oosterhout, J. J., Kumwenda, J., Lalloo, D. G., . . . Khoo, S. H. (2014). Population Pharmacokinetic and Pharmacogenetic Analysis of Nevirapine in Hypersensitive and Tolerant HIV-Infected Patients from Malawi. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(2), 706-712. doi:10.1128/AAC.02069-13

DOI: 10.1128/AAC.02069-13

 

Progastrin-Induced Secretion of Insulin-Like Growth Factor 2 From Colonic Myofibroblasts Stimulates Colonic Epithelial Proliferation in Mice (Journal article)

Duckworth, C. A., Clyde, D., Worthley, D. L., Wang, T. C., Varro, A., & Pritchard, D. M. (2013). Progastrin-Induced Secretion of Insulin-Like Growth Factor 2 From Colonic Myofibroblasts Stimulates Colonic Epithelial Proliferation in Mice. GASTROENTEROLOGY, 145(1), 197-+. doi:10.1053/j.gastro.2013.03.012

DOI: 10.1053/j.gastro.2013.03.012

 

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation. (Journal article)

Rowe, C., Gerrard, D. T., Jenkins, R., Berry, A., Durkin, K., Sundstrom, L., . . . Hanley, N. A. (2013). Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation.. Hepatology (Baltimore, Md.), 58(2), 799-809. doi:10.1002/hep.26414

DOI: 10.1002/hep.26414

 

RXR gene variants are associated with HIV lipodystrophy (Journal article)

Pushpakom, S. P., Owen, A., Back, D. J., & Pirmohamed, M. (2013). RXR gene variants are associated with HIV lipodystrophy. PHARMACOGENETICS AND GENOMICS, 23(8), 438-441. doi:10.1097/FPC.0b013e328362cfc6

DOI: 10.1097/FPC.0b013e328362cfc6

 

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (Journal article)

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., . . . Hengstler, J. G. (2013). Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. ARCHIVES OF TOXICOLOGY, 87(8), 1315-1530. doi:10.1007/s00204-013-1078-5

DOI: 10.1007/s00204-013-1078-5

 

Recent advances in cardiovascular proteomics (Journal article)

Sharma, P., Cosme, J., & Gramolini, A. O. (2013). Recent advances in cardiovascular proteomics. JOURNAL OF PROTEOMICS, 81, 3-14. doi:10.1016/j.jprot.2012.10.026

DOI: 10.1016/j.jprot.2012.10.026

 

Regulation of tumour intracellular pH: A mathematical model examining the interplay between H+ and lactate (Journal article)

Al-Husari, M., & Webb, S. D. (2013). Regulation of tumour intracellular pH: A mathematical model examining the interplay between H+ and lactate. Journal of Theoretical Biology, 322, 58-71. doi:10.1016/j.jtbi.2013.01.007

DOI: 10.1016/j.jtbi.2013.01.007

 

Response to "HLA Allelic Variants and Carbamazepine-Induced Hypersensitivity" (Journal article)

Yip, V. L. M., Pirmohamed, M., & Alfirevic, A. (2013). Response to "HLA Allelic Variants and Carbamazepine-Induced Hypersensitivity". CLINICAL PHARMACOLOGY & THERAPEUTICS, 93(5), 387. doi:10.1038/clpt.2013.5

DOI: 10.1038/clpt.2013.5

 

Role of Nrf2 in protection against acute kidney injury (Journal article)

Shelton, L. M., Park, B. K., & Copple, I. M. (2013). Role of Nrf2 in protection against acute kidney injury.. Kidney international, 84(6), 1090-1095. doi:10.1038/ki.2013.248

DOI: 10.1038/ki.2013.248

 

SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink (Journal article)

Carr, D. F., O'Meara, H., Jorgensen, A. L., Campbell, J., Hobbs, M., McCann, G., . . . Pirmohamed, M. (2013). SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink. CLINICAL PHARMACOLOGY & THERAPEUTICS, 94(6), 695-701. doi:10.1038/clpt.2013.161

DOI: 10.1038/clpt.2013.161

 

Safety pharmacology--current and emerging concepts (Journal article)

Hamdam, J., Sethu, S., Smith, T., Alfirevic, A., Alhaidari, M., Atkinson, J., . . . Goldring, C. (2013). Safety pharmacology--current and emerging concepts.. Toxicology and applied pharmacology, 273(2), 229-241. doi:10.1016/j.taap.2013.04.039

DOI: 10.1016/j.taap.2013.04.039

 

Severity Assessment of Lower Respiratory Tract Infection in Malawi: Derivation of a Novel Index (SWAT-Bp) Which Outperforms CRB-65 (Journal article)

Birkhamshaw, E., Waitt, C. J., Innes, M., & Waitt, P. I. (2013). Severity Assessment of Lower Respiratory Tract Infection in Malawi: Derivation of a Novel Index (SWAT-Bp) Which Outperforms CRB-65. PLoS ONE, 8(12), e82178. doi:10.1371/journal.pone.0082178

DOI: 10.1371/journal.pone.0082178

 

Signaling mediated by the NF-kappa B sub-units NF-kappa B1, NF-kappa B2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice (Journal article)

Burkitt, M. D., Williams, J. M., Duckworth, C. A., O'Hara, A., Hanedi, A., Varro, A., . . . Pritchard, D. M. (2013). Signaling mediated by the NF-kappa B sub-units NF-kappa B1, NF-kappa B2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice. ONCOGENE, 32(50), 5563-5573. doi:10.1038/onc.2013.334

DOI: 10.1038/onc.2013.334

 

Simultaneous population pharmacokinetic modelling of atazanavir and ritonavir in HIV-infected adults and assessment of different dose reduction strategies (Journal article)

Schipani, A., Dickinson, L., Boffito, M., Austin, R., Owen, A., Back, D., . . . Davies, G. (2013). Simultaneous population pharmacokinetic modelling of atazanavir and ritonavir in HIV-infected adults and assessment of different dose reduction strategies. J Acquir Immune Defic Syndr, 62(1), 60-66. doi:10.1097/QAI.0b013e3182737231

DOI: 10.1097/QAI.0b013e3182737231

 

Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet? (Journal article)

Kia, R., Sison, R. L. C., Heslop, J., Kitteringham, N. R., Hanley, N., Mills, J. S., . . . Goldring, C. E. P. (2013). Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?. British Journal of Clinical Pharmacology, 75(4), 885-896. doi:10.1111/j.1365-2125.2012.04360.x

DOI: 10.1111/j.1365-2125.2012.04360.x

 

Stroke pharmacogenetics (Chapter)

Walker, L. E., Stewart, A., & Pirmohamed, M. (2013). Stroke pharmacogenetics. In Stroke Genetics (Vol. 9780857292094, pp. 223-297). doi:10.1007/978-0-85729-209-4_14

DOI: 10.1007/978-0-85729-209-4_14

 

Suppression of core 1 Gal-transferase is associated with reduction of TF and reciprocal increase of Tn, sialyl-Tn and Core 3 glycans in human colon cancer cells. (Journal article)

Barrow, H., Tam, B., Duckworth, C. A., Rhodes, J. M., & Yu, L. -G. (2013). Suppression of core 1 Gal-transferase is associated with reduction of TF and reciprocal increase of Tn, sialyl-Tn and Core 3 glycans in human colon cancer cells.. PloS one, 8(3), e59792. doi:10.1371/journal.pone.0059792

DOI: 10.1371/journal.pone.0059792

 

T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms (Journal article)

Bell, C. C., Faulkner, L., Martinsson, K., Farrell, J., Alfirevic, A., Tugwood, J., . . . Park, B. K. (2013). T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms. CHEMICAL RESEARCH IN TOXICOLOGY, 26(5), 759-766. doi:10.1021/tx400060p

DOI: 10.1021/tx400060p

 

T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms (Journal article)

Bell, C. C., Faulkner, L., Martinsson, K., Farrell, J., Alfirevic, A., Tugwood, J., . . . Park, B. K. (2013). T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms. Chemical Research in Toxicology, 26(5), 759-766. doi:10.1021/tx400060p

DOI: 10.1021/tx400060p

 

The effect of a tuberculosis chest X-ray image reference set on non-expert reader performance. (Journal article)

Waitt, C. J., Joekes, E. C., Jesudason, N., Waitt, P. I., Goodson, P., Likumbo, G., . . . Squire, S. B. (2013). The effect of a tuberculosis chest X-ray image reference set on non-expert reader performance.. European Radiology, 23(9), 2459-2468.

 

The Generation, Detection, and Effects of Reactive Drug Metabolites (Journal article)

Stachulski, A. V., Baillie, T. A., Park, B. K., Obach, R. S., Dalvie, D. K., Williams, D. P., . . . Lennard, M. S. (2013). The Generation, Detection, and Effects of Reactive Drug Metabolites. MEDICINAL RESEARCH REVIEWS, 33(5), 985-1080. doi:10.1002/med.21273

DOI: 10.1002/med.21273

 

The International Serious Adverse Events Consortium (iSAEC) phenotype standardization project for drug-induced torsades de pointes (Journal article)

Behr, E. R., January, C., Schulze-Bahr, E., Grace, A. A., Kaeaeb, S., Fiszman, M., . . . Roden, D. (2013). The International Serious Adverse Events Consortium (iSAEC) phenotype standardization project for drug-induced torsades de pointes. EUROPEAN HEART JOURNAL, 34(26), 1958-1963. doi:10.1093/eurheartj/ehs172

DOI: 10.1093/eurheartj/ehs172

 

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation (Journal article)

Bryan, H. K., Olayanju, A., Goldring, C. E., & Park, B. K. (2013). The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation. Biochemical Pharmacology, 85(6), 705-717. doi:10.1016/j.bcp.2012.11.016

DOI: 10.1016/j.bcp.2012.11.016

 

The role of spatial population structure on the evolution of parasites with acquired immunity and demography (Journal article)

Webb, S. D., Keeling, M. J., & Boots, M. (2013). The role of spatial population structure on the evolution of parasites with acquired immunity and demography. J. Theor. Biol., 324, 21-31. doi:10.1016/j.jtbi.2013.01.01

 

The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK (Journal article)

Alfirevic, A., Carr, D. F., Miyajima, F., Pushpakom, S., Sutton, L., Jorgensen, A. L., & Pirmohamed, M. (2013). The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK. PHARMACOGENOMICS, 14(8), 861-867. doi:10.2217/PGS.13.73

DOI: 10.2217/PGS.13.73

 

The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia (Journal article)

Giannoudis, A., Wang, L., Jorgensen, A. L., Xinarianos, G., Davies, A., Pushpakom, S., . . . Clark, R. E. (2013). The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia. BLOOD, 121(4), 628-637. doi:10.1182/blood-2012-01-405035

DOI: 10.1182/blood-2012-01-405035

 

The hOCT1 single nucleotide polymorphisms M420del and M408V alter imatinib uptake and modify clinical outcome in imatinib treated chronic myeloid leukaemia (Journal article)

Giannoudis, A., Wang, L., Jorgensen, A. L., Xinarianos, G., Davies, A., Pushpakom, S., . . . Clark, R. E. (2013). The hOCT1 single nucleotide polymorphisms M420del and M408V alter imatinib uptake and modify clinical outcome in imatinib treated chronic myeloid leukaemia. Blood, 121, 628-637.

 

The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone (Journal article)

Wright, T., Rea, S. L., Goode, A., Bennett, A. J., Ratajczak, T., Long, J. E., . . . Layfield, R. (2013). The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone.. Bone, 52(2), 699-706. doi:10.1016/j.bone.2012.10.023

DOI: 10.1016/j.bone.2012.10.023

 

Theoretical Predictions of Lactate and Hydrogen ion Distribution in Tumours (Journal article)

Al-Husari, M., & Webb, S. D. (2013). Theoretical Predictions of Lactate and Hydrogen ion Distribution in Tumours. PLOS ONE, 8(8), e72020.

 

TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis (Journal article)

Nyström, S., Antoine, D. J., Lundbäck, P., Lock, J. G., Nita, A. F., Högstrand, K., . . . Applequist, S. E. (2012). TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis. The EMBO Journal, 32(1), 86-99. doi:10.1038/emboj.2012.328

DOI: 10.1038/emboj.2012.328

 

Transport of gabapentin by LAT1 (SLC7A5) (Journal article)

Dickens, D., Webb, S. D., Antonyuk, S., Giannoudis, A., Owen, A., Raedisch, S., . . . Pirmohamed, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). BIOCHEMICAL PHARMACOLOGY, 85(11), 1672-1683. doi:10.1016/j.bcp.2013.03.022

DOI: 10.1016/j.bcp.2013.03.022

 

Variability of antibiotic prescribing in patients with chronic obstructive pulmonary disease exacerbations: a cohort study (Journal article)

Boggon, R., Hubbard, R., Smeeth, L., Gulliford, M., Cassell, J., Eaton, S., . . . van Staa, T. -P. (2013). Variability of antibiotic prescribing in patients with chronic obstructive pulmonary disease exacerbations: a cohort study. BMC PULMONARY MEDICINE, 13. doi:10.1186/1471-2466-13-32

DOI: 10.1186/1471-2466-13-32

 

beta-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis (Journal article)

Jenkins, R. E., Yaseen, F. S., Monshi, M. M., Whitaker, P., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2013). beta-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 26(6), 963-975. doi:10.1021/tx400124m

DOI: 10.1021/tx400124m