2015
A Duplication Copy Number Variation in the Exportin-4 (XPO4) is a Predictor for Histological Severity of Non-Alcoholic Fatty Liver Disease (Journal article)
Zain, S. M., Mohamed, Z., Pirmohamed, M., Tan, H. L., & Mohamed, R. (2015). A Duplication Copy Number Variation in the Exportin-4 (XPO4) is a Predictor for Histological Severity of Non-Alcoholic Fatty Liver Disease. PUBLIC HEALTH GENOMICS, 18, 27. Retrieved from http://gateway.webofknowledge.com/
A comprehensive omics assessment of etanercept therapy for psoriasis (Conference Paper)
Foulkes, A., Rattray, N., Pirmohamed, M., Goodacre, R., Reynolds, N. J., Donaldson, M. J., . . . Warren, R. (2015). A comprehensive omics assessment of etanercept therapy for psoriasis. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 135 (pp. S32). Retrieved from http://gateway.webofknowledge.com/
A comprehensive omics assessment of etanercept therapy for psoriasis (Conference Paper)
Foulkes, A., Rattray, N. J. W., Correa, E., Trivedi, D. K., Carr, D. F., Maratou, K., . . . Warren, R. (2015). A comprehensive omics assessment of etanercept therapy for psoriasis. In BRITISH JOURNAL OF DERMATOLOGY Vol. 173 (pp. 12). Retrieved from http://gateway.webofknowledge.com/
A pilot randomised controlled trial to assess the utility of an e-learning package that trains users in adverse drug reaction causality (Journal article)
Conroy, E. J., Kirkham, J. J., Bellis, J. R., Peak, M., Smyth, R. L., Williamson, P. R., & Pirmohamed, M. (2015). A pilot randomised controlled trial to assess the utility of an e-learning package that trains users in adverse drug reaction causality.. The International journal of pharmacy practice, 23(6), 447-455. doi:10.1111/ijpp.12197
A Thyroid Hormone Receptor/KLF9 Axis in Human Hepatocytes and Pluripotent Stem Cells (Journal article)
Cvoro, A., Devito, L., Milton, F. A., Noli, L., Zhang, A., Filippi, C., . . . Webb, P. (2015). A Thyroid Hormone Receptor/KLF9 Axis in Human Hepatocytes and Pluripotent Stem Cells. STEM CELLS, 33(2), 416-428. doi:10.1002/stem.1875
Nattrass, R., Faulkner, L., Vocanson, M., Antoine, D. J., Kipar, A., Kenna, G., . . . Naisbitt, D. J. (2015). Activation of Flucloxacillin-Specific CD8+T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model. TOXICOLOGICAL SCIENCES, 146(1), 146-156. doi:10.1093/toxsci/kfv077
Acute kidney injury in paediatric oncology patients receiving Cisplatin (Journal article)
Barton, C., Hawcutt, D., Pirmohamed, M., & Pizer, B. (2015). ACUTE KIDNEY INJURY IN PAEDIATRIC ONCOLOGY PATIENTS RECEIVING CISPLATIN. PEDIATRIC BLOOD & CANCER, 62, S302-S303. Retrieved from http://gateway.webofknowledge.com/
Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome (Journal article)
Eakins, R., Walsh, J., Randle, L., Jenkins, R. E., Schuppe-Koistinen, I., Rowe, C., . . . Park, B. K. (2015). Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome. SCIENTIFIC REPORTS, 5. doi:10.1038/srep16423
Adrenal responses to a low-dose short synacthen test in children with asthma (Journal article)
Hawcutt, D. B., Jorgensen, A. L., Wallin, N., Thompson, B., Peak, M., Lacy, D., . . . Smyth, R. L. (2015). Adrenal responses to a low-dose short synacthen test in children with asthma. CLINICAL ENDOCRINOLOGY, 82(5), 648-656. doi:10.1111/cen.12655
Advances in the Pharmacogenomics of Adverse Drug Reactions (Journal article)
Collins, S. L., Carr, D. F., & Pirmohamed, M. (2016). Advances in the Pharmacogenomics of Adverse Drug Reactions. DRUG SAFETY, 39(1), 15-27. doi:10.1007/s40264-015-0367-8
DOI: 10.1007/s40264-015-0367-8
Analysis of VEGF-Mediated ERK5 Activity in Endothelial Cells (Journal article)
Nithianandarajah-Jones, G. N., & Cross, M. J. (2015). Analysis of VEGF-Mediated ERK5 Activity in Endothelial Cells.. Methods in molecular biology (Clifton, N.J.), 1332, 133-142. doi:10.1007/978-1-4939-2917-7_9
DOI: 10.1007/978-1-4939-2917-7_9
Are drug metabolites able to cause T-cell-mediated hypersensitivity reactions? (Journal article)
Sullivan, A., Gibson, A., Park, B. K., & Naisbitt, D. J. (2015). Are drug metabolites able to cause T-cell-mediated hypersensitivity reactions?. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 11(3), 357-368. doi:10.1517/17425255.2015.992780
DOI: 10.1517/17425255.2015.992780
Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin (Journal article)
Meng, X., Maggs, J. L., Usui, T., Whitaker, P., French, N. S., Naisbitt, D. J., & Park, B. K. (2015). Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin. CHEMICAL RESEARCH IN TOXICOLOGY, 28(1), 51-58. doi:10.1021/tx500285k
Baclofen: maintenance of abstinence in alcohol dependent patients attending liver clinic (Conference Paper)
Owens, L., Rose, A., Thompson, A., Pirmohamed, M., Gilmore, I., & Richardson, P. (2015). BACLOFEN: MAINTENANCE OF ABSTINENCE IN ALCOHOL DEPENDENT PATIENTS ATTENDING LIVER CLINIC. In JOURNAL OF HEPATOLOGY Vol. 62 (pp. S767). doi:10.1016/S0168-8278(15)31309-X
DOI: 10.1016/S0168-8278(15)31309-X
bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice (Journal article)
Duckworth, C. A., Abuderman, A. A., Burkitt, M. D., Williams, J. M., O'Reilly, L. A., & Pritchard, D. M. (2015). bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 309(6), G420-G430. doi:10.1152/ajpgi.00404.2014
Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis (Journal article)
Woolbright, B. L., Dorko, K., Antoine, D. J., Clarke, J. I., Gholami, P., Li, F., . . . Jaeschke, H. (2015). Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis. TOXICOLOGY AND APPLIED PHARMACOLOGY, 283(3), 168-177. doi:10.1016/j.taap.2015.01.015
DOI: 10.1016/j.taap.2015.01.015
Breast Milk Pharmacokinetics of Efavirenz and Breastfed Infants' Exposure in Genetically Defined Subgroups of Mother-Infant Pairs: An Observational Study (Journal article)
Olagunju, A., Bolaji, O., Amara, A., Waitt, C., Else, L., Adejuyigbe, E., . . . Owen, A. (2015). Breast Milk Pharmacokinetics of Efavirenz and Breastfed Infants' Exposure in Genetically Defined Subgroups of Mother-Infant Pairs: An Observational Study. CLINICAL INFECTIOUS DISEASES, 61(3), 453-463. doi:10.1093/cid/civ317
Olayanju, A., Copple, I. M., Bryan, H. K., Edge, G. T., Sison, R. L., Wong, M. W., . . . Park, B. K. (2015). Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2. FREE RADICAL BIOLOGY AND MEDICINE, 78, 202-212. doi:10.1016/j.freeradbiomed.2014.11.003
DOI: 10.1016/j.freeradbiomed.2014.11.003
CD4+and CD8+T-cells isolated from blood and skin of patients with beta-lactam hypersensitivity secrete Interleukin-22, but not Interleukin-17 (Conference Paper)
Sullivan, A., Faulkner, L., Farrell, J., Whitaker, P., Peckham, D., Park, B. K., & Naisbitt, D. (2015). CD4+and CD8+T-cells isolated from blood and skin of patients with beta-lactam hypersensitivity secrete Interleukin-22, but not Interleukin-17. In ALLERGY Vol. 70 (pp. 25-26). Retrieved from http://gateway.webofknowledge.com/
CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure (Journal article)
Stutchfield, B. M., Antoine, D. J., Mackinnon, A. C., Gow, D. J., Bain, C. C., Hawley, C. A., . . . Forbes, S. J. (2015). CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure. GASTROENTEROLOGY, 149(7), 1896-+. doi:10.1053/j.gastro.2015.08.053
DOI: 10.1053/j.gastro.2015.08.053
CSF:plasma HIV-1 RNA discordance > 0.5 log(10) is associated with raised inflammatory mediator profiles in CSF (Journal article)
Nightingale, S., Michael, B., King, S., Beloukas, A., Pirmohamed, M., Geretti, A. M., . . . Post, F. (2015). CSF:plasma HIV-1 RNA discordance > 0.5 log(10) is associated with raised inflammatory mediator profiles in CSF. HIV MEDICINE, 16, 7. Retrieved from http://gateway.webofknowledge.com/
Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice (Journal article)
Cai, H., Scott, E., Kholghi, A., Andreadi, C., Rufini, A., Karmokar, A., . . . Brown, K. (2015). Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice. SCIENCE TRANSLATIONAL MEDICINE, 7(298). doi:10.1126/scitranslmed.aaa7619
DOI: 10.1126/scitranslmed.aaa7619
Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate-induced liver injury (Journal article)
Kim, S. -H., Saide, K., Farrell, J., Faulkner, L., Tailor, A., Ogese, M., . . . Naisbitt, D. J. (2015). Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate-induced liver injury. HEPATOLOGY, 62(3), 887-899. doi:10.1002/hep.27912
Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis (Journal article)
Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L. -Y., . . . Yu, L. -G. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. ONCOTARGET, 6(27), 23671-23687. doi:10.18632/oncotarget.4409
Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury (Journal article)
Antoine, D. J., Sabbisetti, V. S., Francis, B., Jorgensen, A. L., Craig, D. G. N., Simpson, K. J., . . . Dear, J. W. (2015). Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury. HEPATOLOGY, 62(2), 591-599. doi:10.1002/hep.27857
Sison-Young, R. L. C., Mitsa, D., Jenkins, R. E., Mottram, D., Alexandre, E., Richert, L., . . . Park, B. K. (2015). Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication. TOXICOLOGICAL SCIENCES, 147(2), 412-424. doi:10.1093/toxsci/kfv136
Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury (Journal article)
Vliegenthart, A. D. B., Shaffer, J. M., Clarke, J. I., Peeters, L. E. J., Caporali, A., Bateman, D. N., . . . Dear, J. W. (2015). Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury. SCIENTIFIC REPORTS, 5. doi:10.1038/srep15501
Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies (Journal article)
Heslop, J. A., Hammond, T. G., Santeramo, I., Piella, A. T., Hopp, I., Zhou, J., . . . Park, B. K. (2015). Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies. STEM CELLS TRANSLATIONAL MEDICINE, 4(4), 389-400. doi:10.5966/sctm.2014-0110
Confocal Endomicroscopy Demonstrates Increased Intestinal Permeability and Gut Dysfunction in Patients With Acute and Chronic Pancreatitis (Conference Paper)
Bharucha, S., Geraghty, J., Duckworth, C. A., Armstrong, J., Szatmary, P., Winn, S. A., . . . Sutton, R. (2015). Confocal Endomicroscopy Demonstrates Increased Intestinal Permeability and Gut Dysfunction in Patients With Acute and Chronic Pancreatitis. In GASTROENTEROLOGY Vol. 148 (pp. S145). Retrieved from http://gateway.webofknowledge.com/
Copy number variation in exportin-4 (XPO4) gene and its association with histological severity of non-alcoholic fatty liver disease (Journal article)
Zain, S. M., Mohamed, Z., Pirmohamed, M., Tan, H. L., Alshawsh, M. A., Mahadeva, S., . . . Mohamed, R. (2015). Copy number variation in exportin-4 (XPO4) gene and its association with histological severity of non-alcoholic fatty liver disease. SCIENTIFIC REPORTS, 5. doi:10.1038/srep13306
Cost-effectiveness of screening for HLA-A*31:01 prior to initiation of carbamazepine in epilepsy (Journal article)
Plumpton, C. O., Yip, V. L. M., Alfirevic, A., Marson, A. G., Pirmohamed, M., & Hughes, D. A. (2015). Cost-effectiveness of screening for HLA-A*31:01 prior to initiation of carbamazepine in epilepsy. EPILEPSIA, 56(4), 556-563. doi:10.1111/epi.12937
Cost-effectiveness of screening for HLA-A*31:01 prior to initiation of carbamazepine in epilepsy (Journal article)
Plumpton, C. O., Yip, V. L., Alfirevic, A., Marson, A. G., Pirmohamed, M., & Hughes, D. A. (2015). Cost-effectiveness of screening for HLA-A*31:01 prior to initiation of carbamazepine in epilepsy. Epilepsia.
Cutaneous immunopathology of long-standing complex regional pain syndrome (Journal article)
Osborne, S., Farrell, J., Dearman, R. J., MacIver, K., Naisbitt, D. J., Moots, R. J., . . . Goebel, A. (2015). Cutaneous immunopathology of long-standing complex regional pain syndrome. EUROPEAN JOURNAL OF PAIN, 19(10), 1516-1526. doi:10.1002/ejp.685
Development and characterisation of a functional 3D liver spheroid model (Conference Paper)
Gaskell, H., Sharma, P., Colley, H., Murdoch, C., Antoine, D., Sathish, J., . . . Webb, S. (2015). Development and characterisation of a functional 3D liver spheroid model. In TOXICOLOGY LETTERS Vol. 238 (pp. S176). doi:10.1016/j.toxlet.2015.08.511
DOI: 10.1016/j.toxlet.2015.08.511
Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography (Journal article)
Sander, K., Galante, E., Gendron, T., Yiannaki, E., Patel, N., Kalber, T. L., . . . Arstad, E. (2015). Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography. JOURNAL OF MEDICINAL CHEMISTRY, 58(15), 6058-6080. doi:10.1021/acs.jmedchem.5b00652
DOI: 10.1021/acs.jmedchem.5b00652
Development of interferon beta-neutralising antibodies in multiple sclerosis-a systematic review and meta-analysis (Journal article)
Govindappa, K., Sathish, J., Park, K., Kirkham, J., & Pirmohamed, M. (2015). Development of interferon beta-neutralising antibodies in multiple sclerosis-a systematic review and meta-analysis. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 71(11), 1287-1298. doi:10.1007/s00228-015-1921-0
DOI: 10.1007/s00228-015-1921-0
DILI: From chemical and metabolism to man (Conference Paper)
Park, B. K. (2015). DILI: From chemical and metabolism to man. In TOXICOLOGY LETTERS Vol. 238 (pp. S39-S40). doi:10.1016/j.toxlet.2015.08.107
DOI: 10.1016/j.toxlet.2015.08.107
Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus (Journal article)
Jenkinson, C., Elliott, V. L., Evans, A., Oldfield, L., Jenkins, R. E., O'Brien, D. P., . . . Costello, E. (2016). Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus. CLINICAL CANCER RESEARCH, 22(7), 1734-1743. doi:10.1158/1078-0432.CCR-15-0879
DOI: 10.1158/1078-0432.CCR-15-0879
Development of interferon beta-neutralising antibodies in multiple sclerosis-a systematic review and meta-analysis (Journal article)
Govindappa, K., Sathish, J., Park, K., Kirkham, J., & Pirmohamed, M. (2015). Development of interferon beta-neutralising antibodies in multiple sclerosis-a systematic review and meta-analysis. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 71(11), 1287-1298. doi:10.1007/s00228-015-1921-0
DOI: 10.1007/s00228-015-1921-0
Epithelial Cell Shedding and Barrier Function: A Matter of Life and Death at the Small Intestinal Villus Tip (Journal article)
Williams, J. M., Duckworth, C. A., Burkitt, M. D., Watson, A. J. M., Campbell, B. J., & Pritchard, D. M. (2015). Epithelial Cell Shedding and Barrier Function: A Matter of Life and Death at the Small Intestinal Villus Tip. VETERINARY PATHOLOGY, 52(3), 445-455. doi:10.1177/0300985814559404
Evaluation of a novel tissue stabilization gel to facilitate clinical sampling for translational research in surgical trials (Journal article)
Sutton, P. A., Jones, R. P., Morrison, F., Goldring, C. E., Park, B. K., Palmer, D. H., . . . Kitteringham, N. R. (2015). Evaluation of a novel tissue stabilization gel to facilitate clinical sampling for translational research in surgical trials. BRITISH JOURNAL OF SURGERY, 102(2), E124-E132. doi:10.1002/bjs.9678
Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function (Journal article)
Sharma, P., Abbasi, C., Lazic, S., Teng, A. C. T., Wang, D., Dubois, N., . . . Gramolini, A. O. (2015). Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. NATURE COMMUNICATIONS, 6. doi:10.1038/ncomms9391
Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study (Journal article)
Lee, K. C. L., Baker, L. A., Stanzani, G., Alibhai, H., Chang, Y. M., Palacios, C. J., . . . Jalan, R. (2015). Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study. JOURNAL OF HEPATOLOGY, 63(3), 634-642. doi:10.1016/j.jhep.2015.04.020
DOI: 10.1016/j.jhep.2015.04.020
Genome-Based Infection Tracking Reveals Dynamics of Clostridium difficile Transmission and Disease Recurrence (Journal article)
Kumar, N., Miyajima, F., He, M., Roberts, P., Swale, A., Ellison, L., . . . Lawley, T. D. (2016). Genome-Based Infection Tracking Reveals Dynamics of Clostridium difficile Transmission and Disease Recurrence. CLINICAL INFECTIOUS DISEASES, 62(6), 746-752. doi:10.1093/cid/civ1031
Genome-wide association study of warfarin maintenance dose in a Brazilian sample (Journal article)
Parra, E. J., Botton, M. R., Perini, J. A., Krithika, S., Bourgeois, S., Johnson, T. A., . . . Suarez-Kurtz, G. (2015). Genome-wide association study of warfarin maintenance dose in a Brazilian sample. PHARMACOGENOMICS, 16(11), 1253-1263. doi:10.2217/pgs.15.73
Genotype-guided versus standard vitamin K antagonist dosing algorithms in patients initiating anticoagulation (Journal article)
Belley-Cote, E. P., Hanif, H., D'Aragon, F., Eikelboom, J. W., Anderson, J. L., Borgman, M., . . . Whitlock, R. P. (2015). Genotype-guided versus standard vitamin K antagonist dosing algorithms in patients initiating anticoagulation. THROMBOSIS AND HAEMOSTASIS, 114(4), 768-777. doi:10.1160/TH15-01-0071
Glutathione metabolism in the HaCaT cell line as a model for the detoxification of the model sensitisers 2,4-dinitrohalobenzenes in human skin (Journal article)
Jacquoilleot, S., Sheffield, D., Olayanju, A., Sison-Young, R., Kitteringham, N. R., Naisbitt, D. J., & Aleksic, M. (2015). Glutathione metabolism in the HaCaT cell line as a model for the detoxification of the model sensitisers 2,4-dinitrohalobenzenes in human skin. TOXICOLOGY LETTERS, 237(1), 11-20. doi:10.1016/j.toxlet.2015.05.016
DOI: 10.1016/j.toxlet.2015.05.016
Health-economic evaluation of clostridium difficile infection (CDI) and epidemiology in England and Merseyside (Journal article)
Nakamura, C. A., Roberts, P., Beadsworth, M., O'Brien, S., Pirmohamed, M., Hughes, D., & Miyajima, F. (2015). HEALTH-ECONOMIC EVALUATION OF CLOSTRIDIUM DIFFICILE INFECTION (CDI) AND EPIDEMIOLOGY IN ENGLAND AND MERSEYSIDE. VALUE IN HEALTH, 18(7), A582. doi:10.1016/j.jval.2015.09.1947
DOI: 10.1016/j.jval.2015.09.1947
HLA-A*33:01 is strongly associated with drug-induced liver injury (DILI) due to terbinafine and several other unrelated compounds (Conference Paper)
Aithal, G. P., Nicoletti, P., Bjornsson, E., Lucena, M. I., Andrade, R. J., Grove, J., . . . Daly, A. K. (2015). HLA-A*33:01 is strongly associated with drug-induced liver injury (DILI) due to terbinafine and several other unrelated compounds. In HEPATOLOGY Vol. 62 (pp. 325A-326A). Retrieved from http://gateway.webofknowledge.com/
HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis (Journal article)
Ogese, M. O., Saide, K., Faulkner, L., Whitaker, P., Peckham, D., Alfirevic, A., . . . Naisbitt, D. J. (2015). HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis. CLINICAL AND EXPERIMENTAL ALLERGY, 45(8), 1305-1316. doi:10.1111/cea.12546
HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis (Journal article)
Castro, E. M. C., Carr, D. F., Jorgensen, A. L., Alfirevic, A., & Pirmohamed, M. (2015). HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis. PHARMACOGENETICS AND GENOMICS, 25(4), 186-198. doi:10.1097/FPC.0000000000000124
DOI: 10.1097/FPC.0000000000000124
Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses (Conference Paper)
Gibson, A., Faulkner, L., Ogese, M., Lichtenfels, M., Esser, P., Martin, S., . . . Naisbitt, D. (2015). Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses. In ALLERGY Vol. 70 (pp. 26). Retrieved from http://gateway.webofknowledge.com/
Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality (Journal article)
Mirza, N., Appleton, R., Burn, S., Carr, D., Crooks, D., du Plessis, D., . . . Pirmohamed, M. (2015). Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality. HUMAN MOLECULAR GENETICS, 24(15), 4306-4316. doi:10.1093/hmg/ddv163
In Vitro Priming of Naive T-cells with p-Phenylenediamine and Bandrowski's Base (Journal article)
Gibson, A., Kim, S. -H., Faulkner, L., Evely, J., Pirmohamed, M., Park, K. B., & Naisbitt, D. J. (2015). In Vitro Priming of Naive T-cells with p-Phenylenediamine and Bandrowski's Base. CHEMICAL RESEARCH IN TOXICOLOGY, 28(10), 2069-2077. doi:10.1021/acs.chemrestox.5b00294
DOI: 10.1021/acs.chemrestox.5b00294
Is infant exposure to antiretroviral drugs during breastfeeding quantitatively important? A systematic review and meta-analysis of pharmacokinetic studies (Journal article)
Waitt, C. J., Garner, P., Bonnett, L. J., Khoo, S. H., & Else, L. J. (2015). Is infant exposure to antiretroviral drugs during breastfeeding quantitatively important? A systematic review and meta-analysis of pharmacokinetic studies. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 70(7), 1928-1941. doi:10.1093/jac/dkv080
Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney (Journal article)
Shelton, L. M., Lister, A., Walsh, J., Jenkins, R. E., Wong, M. H. L., Rowe, C., . . . Copple, I. M. (2015). Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney. KIDNEY INTERNATIONAL, 88(6), 1261-1273. doi:10.1038/ki.2015.286
Intestinal Epithelial Cell Specific Deletion of Nfkb2 Protects Against Immune Cell Derived Damage-Inducing Factors in an Enteroid and Bone Marrow Derived Dendritic Cell Co-Culture System (Conference Paper)
Burkitt, M. D., Jones, L. G., Caamano, J., Pritchard, D. M., & Duckworth, C. A. (2015). Intestinal Epithelial Cell Specific Deletion of Nfkb2 Protects Against Immune Cell Derived Damage-Inducing Factors in an Enteroid and Bone Marrow Derived Dendritic Cell Co-Culture System. In GASTROENTEROLOGY Vol. 148 (pp. S8-S9). Retrieved from http://gateway.webofknowledge.com/
Markers of tubular renal injury in children with cancer receiving Cisplatin and/or Ifosfamide (Journal article)
Barton, C., Hawcutt, D., Pirmohamed, M., & Pizer, B. (2015). MARKERS OF TUBULAR RENAL INJURY IN CHILDREN WITH CANCER RECEIVING CISPLATIN AND/OR IFOSFAMIDE. PEDIATRIC BLOOD & CANCER, 62, S302. Retrieved from http://gateway.webofknowledge.com/
Management of allergy to penicillins and other beta-lactams (Journal article)
Mirakian, R., Leech, S. C., Krishna, M. T., Richter, A. G., Huber, P. A. J., Farooque, S., . . . Nasser, S. M. (2015). Management of allergy to penicillins and other beta-lactams. CLINICAL AND EXPERIMENTAL ALLERGY, 45(2), 300-327. doi:10.1111/cea.12468
Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy (Journal article)
Scarfe, L., Rak-Raszewska, A., Geraci, S., Darssan, D., Sharkey, J., Huang, J., . . . Wilm, B. (2015). Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy. SCIENTIFIC REPORTS, 5. doi:10.1038/srep13601
Metformin increases degradation of phospholamban via autophagy in cardiomyocytes (Journal article)
Teng, A. C. T., Miyake, T., Yokoe, S., Zhang, L., Jr, R. L. M., Sharma, P., . . . Gramolini, A. O. (2015). Metformin increases degradation of phospholamban via autophagy in cardiomyocytes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(23), 7165-7170. doi:10.1073/pnas.1508815112
MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity (Journal article)
Kia, R., Kelly, L., Sison-Young, R. L. C., Zhang, F., Pridgeon, C. S., Heslop, J. A., . . . Park, B. K. (2015). MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity. TOXICOLOGICAL SCIENCES, 144(1), 173-185. doi:10.1093/toxsci/kfu269
Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry (Journal article)
Alfirevic, A., Durocher, J., Elati, A., Leon, W., Dickens, D., Raedisch, S., . . . Winikoff, B. (2015). Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry. PHARMACOGENOMICS, 16(9), 919-928. doi:10.2217/pgs.15.53
Molecular mechanism responsible for tissue stiffness in advanced chronic liver fibrogenesis (Conference Paper)
Sakai, T. (2015). Molecular mechanism responsible for tissue stiffness in advanced chronic liver fibrogenesis. In HEPATOLOGY Vol. 62 (pp. 890A-891A). Retrieved from http://gateway.webofknowledge.com
Monocyte unresponsiveness and impaired IL1 beta, TNF alpha and IL7 production are associated with a poor outcome in Malawian adults with pulmonary tuberculosis (Journal article)
Waitt, C. J., Banda, P., Glennie, S., Kampmann, B., Squire, S. B., Pirmohamed, M., & Heyderman, R. S. (2015). Monocyte unresponsiveness and impaired IL1 beta, TNF alpha and IL7 production are associated with a poor outcome in Malawian adults with pulmonary tuberculosis. BMC INFECTIOUS DISEASES, 15. doi:10.1186/s12879-015-1274-4
DOI: 10.1186/s12879-015-1274-4
Murine Models of Helicobacter (pylori or felis)-associated Gastric Cancer (Journal article)
Duckworth, C. A., Burkitt, M. D., Williams, J. M., Parsons, B. N., Tang, J. M. F., & Pritchard, D. M. (2015). Murine Models of Helicobacter (pylori or felis)-associated Gastric Cancer.. Current protocols in pharmacology, 69, 14.34.1-14.3435. doi:10.1002/0471141755.ph1434s69
DOI: 10.1002/0471141755.ph1434s69
NF-B1, NF-B2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice (Journal article)
Burkitt, M. D., Hanedi, A. F., Duckworth, C. A., Williams, J. M., Tang, J. M., O'Reilly, L. A., . . . Pritchard, D. M. (2015). NF-B1, NF-B2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice. JOURNAL OF PATHOLOGY, 236(3), 326-336. doi:10.1002/path.4527
NFKB1 Deficiency Alters Susceptibility to Helicobacter spp. Induced IL-1 beta Secretion in Bone Marrow Derived Dendritic Cells (Conference Paper)
Tang, J. M., Duckworth, C. A., Pritchard, D. M., Caamano, J., & Burkitt, M. D. (2015). NFKB1 Deficiency Alters Susceptibility to Helicobacter spp. Induced IL-1 beta Secretion in Bone Marrow Derived Dendritic Cells. In GASTROENTEROLOGY Vol. 148 (pp. S118). Retrieved from http://gateway.webofknowledge.com/
Nalmefene in Supporting Alcohol Reduction: Observations from a Clinical Cohort (Journal article)
Owens, L., Thompson, A., Pirmohamed, M., Gilmore, I., & Richardson, P. (2015). Nalmefene in Supporting Alcohol Reduction: Observations from a Clinical Cohort. Journal of Addiction Medicine and Therapy, 3(1).
New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity (Journal article)
Pirmohamed, M., Ostrov, D. A., & Park, B. K. (2015). New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(2), 236-244. doi:10.1016/j.jaci.2015.06.022
DOI: 10.1016/j.jaci.2015.06.022
Observational infant exploratory [C-14]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis (Journal article)
Garner, C. R., Park, K. B., French, N. S., Earnshaw, C., Schipani, A., Selby, A. M., . . . Turner, M. A. (2015). Observational infant exploratory [C-14]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 80(1), 157-167. doi:10.1111/bcp.12597
Oral anticoagulation: a critique of recent advances and controversies (Journal article)
Pirmohamed, M., Kamali, F., Daly, A. K., & Wadelius, M. (2015). Oral anticoagulation: a critique of recent advances and controversies. TRENDS IN PHARMACOLOGICAL SCIENCES, 36(3), 153-163. doi:10.1016/j.tips.2015.01.003
DOI: 10.1016/j.tips.2015.01.003
Paracetamol (acetaminophen) poisoning. (Journal article)
Park, B. K., Dear, J. W., & Antoine, D. J. (2015). Paracetamol (acetaminophen) poisoning.. BMJ clinical evidence, 2015.
Parsing interindividual drug variability: an emerging role for systems pharmacology (Journal article)
Turner, R. M., Park, B. K., & Pirmohamed, M. (2015). Parsing interindividual drug variability: an emerging role for systems pharmacology. WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 7(4), 221-241. doi:10.1002/wsbm.1302
Pediatric Microdose and Microtracer Studies Using C-14 in Europe (Journal article)
Turner, M. A., Mooij, M. G., Vaes, W. H. J., Windhorst, A. D., Hendrikse, N. H., Knibbe, C. A. J., . . . de Wildt, S. N. (2015). Pediatric Microdose and Microtracer Studies Using C-14 in Europe. CLINICAL PHARMACOLOGY & THERAPEUTICS, 98(3), 234-237. doi:10.1002/cpt.163
Personalized medicine approaches in epilepsy (Journal article)
Walker, L. E., Mirza, N., Yip, V. L. M., Marson, A. G., & Pirmohamed, M. (2015). Personalized medicine approaches in epilepsy. JOURNAL OF INTERNAL MEDICINE, 277(2), 218-234. doi:10.1111/joim.12322
Pharmacogenetic Markers of Drug Efficacy and Toxicity (Journal article)
Yip, V. L. M., Hawcutt, D. B., & Pirmohamed, M. (2015). Pharmacogenetic Markers of Drug Efficacy and Toxicity. CLINICAL PHARMACOLOGY & THERAPEUTICS, 98(1), 61-70. doi:10.1002/cpt.135
Pharmacogenetic testing prior to carbamazepine treatment of epilepsy: patients' and physicians' preferences for testing and service delivery (Journal article)
Powell, G., Holmes, E. A. F., Plumpton, C. O., Ring, A., Baker, G. A., Jacoby, A., . . . Hughes, D. A. (2015). Pharmacogenetic testing prior to carbamazepine treatment of epilepsy: patients' and physicians' preferences for testing and service delivery. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 80(5), 1149-1159. doi:10.1111/bcp.12715
Pharmacogenetics of Acute Coronary Syndrome (Conference Paper)
Yin, P., Jorgensen, A., Morris, A. P., Turner, R., Fitzgerald, R., Stables, R., . . . Pirmohamed, M. (2015). Pharmacogenetics of Acute Coronary Syndrome. In GENETIC EPIDEMIOLOGY Vol. 39 (pp. 596). Retrieved from http://gateway.webofknowledge.com/
Pharmacogenetics of adverse drug reactions (Chapter)
Turner, R. M., & Pirmohamed, M. (2015). Pharmacogenetics of adverse drug reactions. In Unknown Book (Vol. 9, pp. 109-156). doi:10.1007/978-3-319-15344-5_6
DOI: 10.1007/978-3-319-15344-5_6
Pharmacogenomics: The Hierarchy of Evidence (Journal article)
Pirmohamed, M. (2015). Pharmacogenomics: The Hierarchy of Evidence. PUBLIC HEALTH GENOMICS, 18, 2. Retrieved from http://gateway.webofknowledge.com/
Pharmacotherapy for alcohol dependence: A stratified approach (Journal article)
Thompson, A., Owens, L., Pushpakom, S. P., Faizal, M., & Pirmohamed, M. (2015). Pharmacotherapy for alcohol dependence: A stratified approach. PHARMACOLOGY & THERAPEUTICS, 153, 10-24. doi:10.1016/j.pharmthera.2015.05.010
DOI: 10.1016/j.pharmthera.2015.05.010
Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes (Journal article)
Baxter, M., Withey, S., Harrison, S., Segeritz, C. -P., Zhang, F., Atkinson-Dell, R., . . . Hanley, N. A. (2015). Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes. JOURNAL OF HEPATOLOGY, 62(3), 581-589. doi:10.1016/j.jhep.2014.10.016
DOI: 10.1016/j.jhep.2014.10.016
Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury (Journal article)
Cross, M. J., Berridge, B. R., Clements, P. J. M., Cove-Smith, L., Force, T. L., Hoffmann, P., . . . Park, B. K. (2015). Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury. BRITISH JOURNAL OF PHARMACOLOGY, 172(4), 957-974. doi:10.1111/bph.12979
Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy (Conference Paper)
O'Hara, A., Burkitt, M. D., Carr, D. F., Alfirevic, A., Moore, A. R., Murugesan, S. V., . . . Pritchard, D. M. (2015). Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy. In GASTROENTEROLOGY Vol. 148 (pp. S566). Retrieved from http://gateway.webofknowledge.com/
Prescribing in liver disease (Journal article)
Pirmohamed, M. (2015). Prescribing in liver disease. Medicine, 43(10), 577-580. doi:10.1016/j.mpmed.2015.07.015
DOI: 10.1016/j.mpmed.2015.07.015
Promiscuous T-cell responses to drugs and drug-haptens (Journal article)
Yaseen, F. S., Saide, K., Kim, S. -H., Monshi, M., Tailor, A., Wood, S., . . . Naisbitt, D. J. (2015). Promiscuous T-cell responses to drugs and drug-haptens. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(2), 474-+. doi:10.1016/j.jaci.2015.02.036
DOI: 10.1016/j.jaci.2015.02.036
Proteomic analysis to identify biomarkers in the primary tumour that predict response to neoadjuvant chemotherapy in liver metastases (Journal article)
Sutton, P., Evans, J., Jones, R., Malik, H., Vimalachandran, D., Palmer, D., . . . Kitteringham, N. (2015). Proteomic analysis to identify biomarkers in the primary tumour that predict response to neoadjuvant chemotherapy in liver metastases. LANCET, 385, 95. Retrieved from http://gateway.webofknowledge.com/
Quality of life in patients with venous thromboembolism and atrial fibrillation treated with coumarin anticoagulants (Journal article)
Marvig, C. L., Verhoef, T. I., de Boer, A., Kamali, F., Redekop, K., Pirmohamed, M., . . . Consortium, E. U. -P. A. C. T. (2015). Quality of life in patients with venous thromboembolism and atrial fibrillation treated with coumarin anticoagulants. THROMBOSIS RESEARCH, 136(1), 69-75. doi:10.1016/j.thromres.2015.04.026
DOI: 10.1016/j.thromres.2015.04.026
Quantification of Drug-Induced Inhibition of Canalicular Cholyl-L-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging (Journal article)
Barber, J. A., Stahl, S. H., Summers, C., Barrett, G., Park, B. K., Foster, J. R., & Kenna, J. G. (2015). Quantification of Drug-Induced Inhibition of Canalicular Cholyl-L-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging. TOXICOLOGICAL SCIENCES, 148(1), 48-59. doi:10.1093/toxsci/kfv159
Redefining antigen binding specificity through small molecule-HLA interactions: Drug hypersensitivity and beyond! (Conference Paper)
Illing, P. T., Vivian, J. P., Dudek, N. L., Mifsud, N. L., Croft, N. P., Miles, J. J., . . . Purcell, A. W. (2015). Redefining antigen binding specificity through small molecule-HLA interactions: Drug hypersensitivity and beyond!. In MOLECULAR IMMUNOLOGY Vol. 68 (pp. 135). Retrieved from http://gateway.webofknowledge.com/
Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy (Conference Paper)
Wheatley, L. M., Plaut, M., Schwaninger, J. M., Banerji, A., Castells, M., Finkelman, F. D., . . . Trepanier, L. A. (2015). Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy. In JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Vol. 136 (pp. 262-+). doi:10.1016/j.jaci.2015.05.027
DOI: 10.1016/j.jaci.2015.05.027
ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults (Journal article)
Vijverberg, S. J. H., Koster, E. S., Tavendale, R., Leusink, M., Koenderman, L., Raaijmakers, J. A. M., . . . Maitland-van der Zee, A. H. (2015). ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults. CLINICAL AND EXPERIMENTAL ALLERGY, 45(6), 1051-1059. doi:10.1111/cea.12492
Social media and pharmacovigilance: A review of the opportunities and challenges (Journal article)
Sloane, R., Osanlou, O., Lewis, D., Bollegala, D., Maskell, S., & Pirmohamed, M. (2015). Social media and pharmacovigilance: A review of the opportunities and challenges. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 80(4), 910-920. doi:10.1111/bcp.12717
Su1978 Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy (Journal article)
O'Hara, A., Burkitt, M., Carr, D., Alfirevic, A., Moore, A., Murugesan, S., . . . Pritchard, M. (2015). Su1978 Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy.
Tamoxifen induced gastric atrophy is regulated by the NF-B subunit NFKB1 (Conference Paper)
Williams, J. M., Norman, R., Tang, J. M., Duckworth, C. A., Caamano, J., Pritchard, D. M., & Burkitt, M. D. (2015). TAMOXIFEN INDUCED GASTRIC ATROPHY IS REGULATED BY THE NF-B SUBUNIT NFKB1. In GUT Vol. 64 (pp. A482). doi:10.1136/gutjnl-2015-309861.1056
DOI: 10.1136/gutjnl-2015-309861.1056
Pushpakom, S. P., Taylor, C., Kolamunnage-Dona, R., Spowart, C., Vora, J., Garcia-Finana, M., . . . Pirmohamed, M. (2015). Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of telmisartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on combination antiretroviral therapy. BMJ OPEN, 5(10). doi:10.1136/bmjopen-2015-009566
DOI: 10.1136/bmjopen-2015-009566
The chemical, genetic and immunological basis of idiosyncratic drug-induced liver injury (Journal article)
Tailor, A., Faulkner, L., Naisbitt, D. J., & Park, B. K. (2015). The chemical, genetic and immunological basis of idiosyncratic drug-induced liver injury. HUMAN & EXPERIMENTAL TOXICOLOGY, 34(12), 1310-1317. doi:10.1177/0960327115606529
The Influence of Pharmacogenetics on the Time to Acute Coronary Syndrome Recurrence in a UK Cohort Study (Conference Paper)
Yin, P., Jorgensen, A., Morris, A., Turner, R., Fitzgerald, R., Stables, R., . . . Pirmohamed, M. (2015). The Influence of Pharmacogenetics on the Time to Acute Coronary Syndrome Recurrence in a UK Cohort Study. In HUMAN HEREDITY Vol. 80 (pp. 123). Retrieved from http://gateway.webofknowledge.com/
The Phenotype and Function of Hapten specific T-Cell isolated from Hypersensitive patients and healthy human donors (Thesis / Dissertation)
Wang, E. (2015, August 3). The Phenotype and Function of Hapten specific T-Cell isolated fromHypersensitive patients and healthy human donors.
The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death (Journal article)
Kamalian, L., Chadwick, A. E., Bayliss, M., French, N. S., Monshouwer, M., Snoeys, J., & Park, B. K. (2015). The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death. TOXICOLOGY IN VITRO, 29(4), 732-740. doi:10.1016/j.tiv.2015.02.011
DOI: 10.1016/j.tiv.2015.02.011
Three Huntington's Disease Specific Mutation-Carrying Human Embryonic Stem Cell Lines Have Stable Number of CAG Repeats upon In Vitro Differentiation into Cardiomyocytes (Journal article)
Jacquet, L., Neueder, A., Foeldes, G., Karagiannis, P., Hobbs, C., Jolinon, N., . . . Ilic, D. (2015). Three Huntington's Disease Specific Mutation-Carrying Human Embryonic Stem Cell Lines Have Stable Number of CAG Repeats upon In Vitro Differentiation into Cardiomyocytes. PLOS ONE, 10(5). doi:10.1371/journal.pone.0126860
DOI: 10.1371/journal.pone.0126860
Eagle, G. L., Zhuang, J., Jenkins, R. E., Till, K. J., Jithesh, P. V., Lin, K., . . . Pettitt, A. R. (2015). Total Proteome Analysis Identifies Migration Defects as a Major Pathogenetic Factor in Immunoglobulin Heavy Chain Variable Region (IGHV)-unmutated Chronic Lymphocytic Leukemia. MOLECULAR & CELLULAR PROTEOMICS, 14(4), 933-945. doi:10.1074/mcp.M114.044479
Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57:01-restricted CD8(+) T-cell activation (Journal article)
Naisbitt, D. J., Yang, E. L., Alhaidari, M., Berry, N. G., Lawrenson, A. S., Farrell, J., . . . Park, B. K. (2015). Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57:01-restricted CD8(+) T-cell activation. AIDS, 29(18), 2385-2395. doi:10.1097/QAD.0000000000000867
DOI: 10.1097/QAD.0000000000000867
Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity (Journal article)
Duran-Figueroa, N., Badillo-Corona, J. A., Naisbitt, D. J., & Castrejon-Flores, J. L. (2015). Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity. TOXICOLOGY RESEARCH, 4(4), 777-795. doi:10.1039/c4tx00238e
Understanding and Assessing the Risks of Stem Cell-Based Therapies (Journal article)
Heslop, J., Hammond, T. G., Santeramo, I., Tort Piella, A., Hopp, I., Zhou, J., . . . Park, B. (2015). Understanding and Assessing the Risks of Stem Cell-Based Therapies. Stem Cells Translational Medicine, 4, 389-400.
Understanding the Pathophysiological Regulatory Role of MicroRNAs in Acute Liver Failure (Journal article)
Antoine, D. J., Dear, J. W., Goldring, C. E., & Park, B. K. (2015). Understanding the Pathophysiological Regulatory Role of MicroRNAs in Acute Liver Failure. HEPATOLOGY, 61(4), 1439-1440. doi:10.1002/hep.27349
Validation and clinical application of a method to quantify nevirapine in dried blood spots and dried breast-milk spots (Journal article)
Olagunju, A., Amara, A., Waitt, C., Else, L., Penchala, S. D., Bolaji, O., . . . Khoo, S. (2015). Validation and clinical application of a method to quantify nevirapine in dried blood spots and dried breast-milk spots. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 70(10), 2816-2822. doi:10.1093/jac/dkv174
Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress (Journal article)
Mutter, F. E., Park, B. K., & Copple, I. M. (2015). Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress. BIOCHEMICAL SOCIETY TRANSACTIONS, 43, 657-662. doi:10.1042/BST20150044
Variation in warfarin prescribing and dosing in the UK: a national survey of anticoagulation clinics (Journal article)
Stewart, A., Ganguli, A., FitzGerald, R., & Pirmohamed, M. (2015). Variation in warfarin prescribing and dosing in the UK: a national survey of anticoagulation clinics. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 40(4), 466-471. doi:10.1111/jcpt.12291
Where are we now with paracetamol? (Journal article)
Dear, J. W., Antoine, D. J., & Park, B. K. (2015). Where are we now with paracetamol?. BMJ-BRITISH MEDICAL JOURNAL, 351. doi:10.1136/bmj.h3705