2009
A Mechanistic Investigation into the Irreversible Protein Binding and Antigenicity of p-Phenylenediamine (Journal article)
Jenkinson, C., Jenkins, R. E., Maggs, J. L., Kitteringham, N. R., Aleksic, M., Park, B. K., & Naisbitt, D. J. (2009). A Mechanistic Investigation into the Irreversible Protein Binding and Antigenicity of p-Phenylenediamine. CHEMICAL RESEARCH IN TOXICOLOGY, 22(6), 1172-1180. doi:10.1021/tx900095r
A pathological environment can modify sulfamethoxazole metabolism in human antigen presenting cells, including dendritic cells (Conference Paper)
Lavergne, S. N., Wang, H., Park, B. K., & Naisbitt, D. J. (2009). A pathological environment can modify sulfamethoxazole metabolism in human antigen presenting cells, including dendritic cells. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 293-294). Retrieved from http://gateway.webofknowledge.com/
A study of plasma levels of Imatinib and its bioactive metabolite CGP-74588 reveals no correlation with subsequent clinical outcome in Imatinib-treated chronic myeloid leukaemia (Conference Paper)
Davies, A., Hayes, A. K., Giannoudis, A., Lucas, C. M., Knight, K., Watmough, S. J., . . . Clark, R. E. (2009). A STUDY OF PLASMA LEVELS OF IMATINIB AND ITS BIOACTIVE METABOLITE CGP-74588 REVEALS NO CORRELATION WITH SUBSEQUENT CLINICAL OUTCOME IN IMATINIB-TREATED CHRONIC MYELOID LEUKAEMIA. In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL Vol. 94 (pp. 259). Retrieved from http://gateway.webofknowledge.com/
An Investigation of the expression of cytochrome P450 3A7 and cytochrome P450 3A4 during stem cell differentiation for use as markers of emerging hepatic phenotype (Conference Paper)
Curley, P., Kelly, L., Shaw, R., Kitteringham, N., Jenkins, R., Alder, J., . . . Park, K. (2009). An Investigation of the expression of cytochrome P450 3A7 and cytochrome P450 3A4 during stem cell differentiation for use as markers of emerging hepatic phenotype. In British Pharmacology Society Winter Meeting. London, UK.
Anticipating adverse drug reactions (Conference Paper)
Pirmohamed, M. (2009). ANTICIPATING ADVERSE DRUG REACTIONS. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 105 (pp. 3). Retrieved from http://gateway.webofknowledge.com/
Antitumour and antimalarial activity of artemisinin-acridine hybrids (Journal article)
Jones, M., Mercer, A. E., Stocks, P. A., La Pensee, L. J. I., Cosstick, R., Park, B. K., . . . O'Neill, P. M. (2009). Antitumour and antimalarial activity of artemisinin-acridine hybrids. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(7), 2033-2037. doi:10.1016/j.bmcl.2009.02.028
DOI: 10.1016/j.bmcl.2009.02.028
Adipogenic gene variants in patients with HIV-associated lipodystrophy (Conference Paper)
Pushpakom, S., Owen, A., Vilar, J., Back, D., & Pirmohamed, M. (2009). Adipogenic gene variants in patients with HIV-associated lipodystrophy. In HIV MEDICINE Vol. 10 (pp. 1). Retrieved from http://gateway.webofknowledge.com/
Adverse Drug Reactions in Hospital In-Patients: A Prospective Analysis of 3695 Patient-Episodes (Journal article)
Davies, E. C., Green, C. F., Taylor, S., Williamson, P. R., Mottram, D. R., & Pirmohamed, M. (2009). Adverse Drug Reactions in Hospital In-Patients: A Prospective Analysis of 3695 Patient-Episodes. PLOS ONE, 4(2). doi:10.1371/journal.pone.0004439
DOI: 10.1371/journal.pone.0004439
Bioactivation of nevirapine: characterization and quantification of nevirapine mercapturate in human urine (Journal article)
Srivastava, A., Williams, D. P., Maggs, J. L., Lian, L. Y., Gardner, I., Chaponda, M., . . . Park, B. K. (2009). Bioactivation of nevirapine: characterization and quantification of nevirapine mercapturate in human urine. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 68(2), 276-277. Retrieved from http://gateway.webofknowledge.com/
O'Neill, P. M., Park, B. K., Shone, A. E., Maggs, J. L., Roberts, P., Stocks, P. A., . . . Ward, S. A. (2009). Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century. JOURNAL OF MEDICINAL CHEMISTRY, 52(5), 1408-1415. doi:10.1021/jm8012618
Carbonic Anhydrase Inhibitor-Induced Renal Tubular Acidosis (Conference Paper)
Mirza, N., Marson, A. G., & Pirmohamed, M. (2009). CARBONIC ANHYDRASE INHIBITOR-INDUCED RENAL TUBULAR ACIDOSIS. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 105 (pp. 84). Retrieved from http://gateway.webofknowledge.com/
Carbonic Anhydrase Inhibitor-Induced Renal Tubular Acidosis (Conference Paper)
Mirza, N., Marson, A., & Pirmohamed, M. (2009). CARBONIC ANHYDRASE INHIBITOR-INDUCED RENAL TUBULAR ACIDOSIS. In EPILEPSIA Vol. 50 (pp. 109). Retrieved from http://gateway.webofknowledge.com/
Carbonic Anhydrase Inhibitor-Induced Renal Tubular Acidosis (Conference Paper)
Mirza, N. S., Pirmohamed, M., & Marson, A. G. (2009). CARBONIC ANHYDRASE INHIBITOR-INDUCED RENAL TUBULAR ACIDOSIS. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 80. doi:10.1136/jnnp.2009.191775i
Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo (Journal article)
Jenkins, R. E., Meng, X., Elliott, V. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (2009). Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo. PROTEOMICS CLINICAL APPLICATIONS, 3(6), 720-729. doi:10.1002/prca.200800222
Characterisation of p-phenylenediamine and Bandrowski's base-specific T-cell responses in the mouse. (Journal article)
Farrell, J., Jenkinson, C., Lavergne, S. N., Maggs, J. L., Park, B. K., & Naisbitt, D. J. (2009). Characterisation of p-phenylenediamine and Bandrowski's base-specific T-cell responses in the mouse.. Toxicol Lett., 185(153-15).
Characterization of SMX disposition in bone marrow-derived dendritic cells, as a part of a mouse model of SMX immunogenicity (Conference Paper)
Elsheikh, A., Lavergne, S. N., Sathish, J., Park, B. K., & Naisbitt, D. J. (2009). Characterization of SMX disposition in bone marrow-derived dendritic cells, as a part of a mouse model of SMX immunogenicity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 287-288). Retrieved from http://gateway.webofknowledge.com/
Characterization and Quantification of Mercapturate and Glutathione Conjugates of Nevirapine (Conference Paper)
Srivastava, A., Williams, D. P., Maggs, J. L., Lian, L. -Y., Chaponda, M., Gardner, I., . . . Park, K. (2009). Characterization and Quantification of Mercapturate and Glutathione Conjugates of Nevirapine. In TOXICOLOGY Vol. 262 (pp. 6-7). doi:10.1016/j.tox.2009.04.051
DOI: 10.1016/j.tox.2009.04.051
Clinical management of HIV-associated lipodystrophy (Journal article)
Pirmohamed, M. (2009). Clinical management of HIV-associated lipodystrophy. CURRENT OPINION IN LIPIDOLOGY, 20(4), 309-314. doi:10.1097/MOL.0b013e32832d3bb1
DOI: 10.1097/MOL.0b013e32832d3bb1
Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials (Journal article)
Davis, C. B., Bambal, R., Moorthy, G. S., Hugger, E., Xiang, H., Park, B. K., . . . Ward, S. A. (2009). Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials. Journal of Pharmaceutical Sciences, 98(1), 362-377. doi:10.1002/jps.21469
Correction: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial (Journal article)
Roberts, S. H., Bedson, E., Hughes, D. A., Lloyd, K. R., Menkes, D. B., Moat, S. J., . . . Russell, I. T. (2009). Correction: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial.. BMC psychiatry, 9, 14. doi:10.1186/1471-244X-9-14
"Danger" Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells (Journal article)
Lavergne, S. N., Wang, H., Callan, H. E., Park, B. K., & Naisbitt, D. J. (2009). "Danger" Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 331(2), 372-381. doi:10.1124/jpet.109.155374
Deletion of exon 3 in the growth hormone receptor gene in adults with growth hormone deficiency: comparison of symptomatic and asymptomatic patients (Journal article)
Adetunji, O. R., Blair, J. C., Javadpour, M., Alfirevic, A., Pirmohamed, M., & MacFarlane, I. A. (2010). Deletion of exon 3 in the growth hormone receptor gene in adults with growth hormone deficiency: comparison of symptomatic and asymptomatic patients. CLINICAL ENDOCRINOLOGY, 72(3), 422-423. doi:10.1111/j.1365-2265.2009.03638.x
DOI: 10.1111/j.1365-2265.2009.03638.x
EMERGENCY READMISSIONS TO HOSPITAL DUE TO ADVERSE DRUG REACTIONS (ADRS): A RETROSPECTIVE STUDY (Conference Paper)
Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2009). EMERGENCY READMISSIONS TO HOSPITAL DUE TO ADVERSE DRUG REACTIONS (ADRS): A RETROSPECTIVE STUDY. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 105 (pp. 34). Retrieved from http://gateway.webofknowledge.com/
Effect of topiramate on acid-base balance: extent, mechanism and effects (Journal article)
Mirza, N., Marson, A. G., & Pirmohamed, M. (2009). Effect of topiramate on acid-base balance: extent, mechanism and effects. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 68(5), 655-661. doi:10.1111/j.1365-2125.2009.03521.x
DOI: 10.1111/j.1365-2125.2009.03521.x
Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy (Journal article)
Zhang, J. E., Jorgensen, A. L., Alfirevic, A., Williamson, P. R., Toh, C. H., Park, B. K., & Pirmohamed, M. (2009). Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy. PHARMACOGENETICS AND GENOMICS, 19(10), 781-789. doi:10.1097/FPC.0b013e3283311347
DOI: 10.1097/FPC.0b013e3283311347
Effects of genetic variation at the CYP219/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians (Journal article)
Janha, R. E., Sisay-Joof, F., Hamid-Adiamoh, M., Worwui, A., Chapman, H. L., Opara, H., . . . Walton, R. T. (2009). Effects of genetic variation at the CYP219/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians. PHARMACOGENOMICS, 10(9), 1423-1431. doi:10.2217/PGS.09.72
ERK5 and the regulation of endothelial cell function (Journal article)
Roberts, O., Holmes, K., Müller, J., Cross, D., & Cross, M. (2009). ERK5 and the regulation of endothelial cell function. Biochemical Society Transactions, 37(6), 1254-1259. doi:10.1042/BST0371254
Erratum to: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial (Journal article)
Roberts, S. H., Bedson, E., Hughes, D. A., Lloyd, K. R., Menkes, D. B., Moat, S. J., . . . Russell, I. T. (2009). Erratum to: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial. BMC Psychiatry, 9(1). doi:10.1186/1471-244X-9-14
Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data (Journal article)
Klein, T. E., Altman, R. B., Eriksson, N., Gage, B. F., Kimmel, S. E., Lee, M. -T. M., . . . Cons, I. W. P. (2009). Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data. NEW ENGLAND JOURNAL OF MEDICINE, 360(8), 753-764. Retrieved from http://gateway.webofknowledge.com/
Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data (vol 360, pg 753, 2009) (Journal article)
Klein, T. E., Altman, R. B., Eriksson, N., Gage, B. F., Kimmel, S. E., Lee, M. T. M., . . . Shin, J. G. (2009). Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data (vol 360, pg 753, 2009). NEW ENGLAND JOURNAL OF MEDICINE, 361(16), 1613. Retrieved from http://gateway.webofknowledge.com/
Extract of Ginkgo biloba induces glutathione-S-transferase subunit-P1 in vitro (Journal article)
Liu, X. -P., Goldring, C. E. P., Wang, H. -Y., Copple, I. M., Kitteringham, N. R., & Park, B. K. (2009). Extract of Ginkgo biloba induces glutathione-S-transferase subunit-P1 in vitro. PHYTOMEDICINE, 16(5), 451-455. doi:10.1016/j.phymed.2008.11.001
DOI: 10.1016/j.phymed.2008.11.001
Mercer, A. E., Regan, S. L., Hirst, C. M., Graham, E. E., Antoine, D. J., Benson, C. A., . . . Park, B. K. (2009). Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis. TOXICOLOGY AND APPLIED PHARMACOLOGY, 239(3), 297-305. doi:10.1016/j.taap.2009.05.027
DOI: 10.1016/j.taap.2009.05.027
Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study (Journal article)
Jorgensen, A. L., Al-Zubiedi, S., Zhang, J. E., Keniry, A., Hanson, A., Hughes, D. A., . . . Pirmohamed, M. (2009). Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study. PHARMACOGENETICS AND GENOMICS, 19(10), 800-812. doi:10.1097/FPC.0b013e3283317ab5
DOI: 10.1097/FPC.0b013e3283317ab5
Genotype-guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design (Journal article)
van Schie, R. M. F., Wadelius, M., Kamali, F., Daly, A. K., Manolopoulos, V. G., de Boer, A., . . . Maitland-van der Zee, A. -H. (2009). Genotype-guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design. PHARMACOGENOMICS, 10(10), 1687-1695. doi:10.2217/PGS.09.125
HLA-B(star)5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin (Journal article)
Daly, A. K., Donaldson, P. T., Bhatnagar, P., Shen, Y., Pe'er, I., Floratos, A., . . . Consortium, I. S. A. E. (2009). HLA-B(star)5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. NATURE GENETICS, 41(7), 816-U71. doi:10.1038/ng.379
Human antigen presenting cells can metabolize sulfamethoxazole to a protein reactive intermediate, leading to the formation of intracellular drug adducts that can stimulate drug specific T-cells from allergic patients (Conference Paper)
Lavergne, S. N., Wang, H., Castrejon, J. L., Park, B. K., & Naisbitt, D. J. (2009). Human antigen presenting cells can metabolize sulfamethoxazole to a protein reactive intermediate, leading to the formation of intracellular drug adducts that can stimulate drug specific T-cells from allergic patients. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 279). Retrieved from http://gateway.webofknowledge.com/
High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo (Journal article)
Antoine, D. J., Williams, D. P., Kipar, A., Jenkins, R. E., Regan, S. L., Sathish, J. G., . . . Park, B. K. (2009). High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo.. Toxicological sciences : an official journal of the Society of Toxicology, 112(2), 521-531. doi:10.1093/toxsci/kfp235
Impact Of Pharmacogenetics On The Costs Of Managing Adverse Events With Warfarin: A Prospective Analysis (Journal article)
Hughes, D. A., Al-Zubiedi, S., Hanson, A., Jorgensen, A., & Pirmohamed, M. (2009). IMPACT OF PHARMACOGENETICS ON THE COSTS OF MANAGING ADVERSE EVENTS WITH WARFARIN: A PROSPECTIVE ANALYSIS. VALUE IN HEALTH, 12(3), A3-A4. doi:10.1016/S1098-3015(10)73081-3
DOI: 10.1016/S1098-3015(10)73081-3
In Vivo and In Vitro Efficacy of Amodiaquine against Plasmodium falciparum in an Area of Continued Use of 4-Aminoquinolines in East Africa (Journal article)
Sasi, P., Abdulrahaman, A., Mwai, L., Muriithi, S., Straimer, J., Schieck, E., . . . Borrmann, S. (2009). In Vivo and In Vitro Efficacy of Amodiaquine against Plasmodium falciparum in an Area of Continued Use of 4-Aminoquinolines in East Africa. JOURNAL OF INFECTIOUS DISEASES, 199(11), 1575-1582. doi:10.1086/598862
Inflammatory Stress and Idiosyncratic Hepatotoxicity: Hints from Animal Models (Journal article)
Deng, X., Luyendyk, J. P., Ganey, P. E., & Roth, R. A. (2009). Inflammatory Stress and Idiosyncratic Hepatotoxicity: Hints from Animal Models. Pharmacological Reviews, 61(3), 262-282. doi:10.1124/pr.109.001727
Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review (Journal article)
Carr, D. F., Whiteley, G., Alfirevic, A., Pirmohamed, M., & Team, F. S. (2009). Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review. PHARMACOGENOMICS JOURNAL, 9(5), 291-305. doi:10.1038/tpj.2009.29
Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base in the mouse (Journal article)
Farrell, J., Jenkinson, C., Lavergne, S. N., Maggs, J. L., Park, B. K., & Naisbitt, D. J. (2009). Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base in the mouse. TOXICOLOGY LETTERS, 185(3), 153-159. doi:10.1016/j.toxlet.2008.12.008
DOI: 10.1016/j.toxlet.2008.12.008
Involvement of drug-specific CD4(+) and CD8(+) T-cells in trimethoprim-mediated hepatitis (Conference Paper)
El-Ghaiesh, S., Lavergne, S., Farell, J., Syn, W., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2009). Involvement of drug-specific CD4(+) and CD8(+) T-cells in trimethoprim-mediated hepatitis. In TOXICOLOGY Vol. 262 (pp. 12). doi:10.1016/j.tox.2009.04.010
DOI: 10.1016/j.tox.2009.04.010
MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins (Journal article)
Lam, D., Dickens, D., Reid, E. B., Loh, S. H. Y., Moisoi, N., & Martins, L. M. (2009). MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(29), 11978-11983. doi:10.1073/pnas.0900608106
Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals (Journal article)
Coulter, E. M., Jenkinson, C., Farrell, J., Lavergne, S. N., Pease, C., White, A., . . . Naisbitt, D. J. (2010). Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals. Journal of Investigative Dermatology, 130(1), 161-174. doi:10.1038/jid.2009.187
Measurement of lymphocyte proliferation and cytokine secretion from para-phenylenediamine allergic patients and tolerant individuals (Conference Paper)
Jenkinson, C., Aleksic, M., Lavergne, S. N., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2009). Measurement of lymphocyte proliferation and cytokine secretion from para-phenylenediamine allergic patients and tolerant individuals. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 280). Retrieved from http://gateway.webofknowledge.com/
Mechanism-based bioanalysis and biomarkers for hepatic chemical stress (Journal article)
Antoine, D. J., Mercer, A. E., Williams, D. P., & Park, B. K. (2009). Mechanism-based bioanalysis and biomarkers for hepatic chemical stress. XENOBIOTICA, 39(8), 565-577. doi:10.1080/00498250903046993
DOI: 10.1080/00498250903046993
Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation (Journal article)
Callan, H. E., Jenkins, R. E., Maggs, J. L., Lavergne, S. N., Clarke, S. E., Naisbitt, D. J., & Park, B. K. (2009). Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation. CHEMICAL RESEARCH IN TOXICOLOGY, 22(5), 937-948. doi:10.1021/tx900034r
Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics (Journal article)
Kitteringham, N. R., Jenkins, R. E., Lane, C. S., Elliott, V. L., & Park, B. K. (2009). Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(13), 1229-1239. doi:10.1016/j.jchromb.2008.11.013
DOI: 10.1016/j.jchromb.2008.11.013
Nevirapine hypersensitivity in Malawi: a prospective cohort study (Conference Paper)
Chaponda, M., Khoo, S. H., Oosterhout, J. V., Kumwenda, J., Lalloo, D., & Pirmohamed, M. (2009). Nevirapine hypersensitivity in Malawi: a prospective cohort study. In HIV MEDICINE Vol. 10 (pp. 34-35). Retrieved from http://gateway.webofknowledge.com/
Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters (Journal article)
Davies, A., Jordanides, N. E., Giannoudis, A., Lucas, C. M., Hatziieremia, S., Harris, R. J., . . . Mountford, J. C. (2009). Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters. LEUKEMIA, 23(11), 1999-2006. doi:10.1038/leu.2009.166
Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GA(2)LEN platform. The Galenda project (Journal article)
Bousquet, P. -J., Demoly, P., Romano, A., Aberer, W., Bircher, A., Blanca, M., . . . ENDA. (2009). Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GA(2)LEN platform. The Galenda project. ALLERGY, 64(2), 194-203. doi:10.1111/j.1398-9995.2008.01944.x
DOI: 10.1111/j.1398-9995.2008.01944.x
RELEASE OF INTRACELLULAR CALCIUM PRIMES CHRONIC MYELOID LEUKAEMIA CELLS FOR TYROSINE KINASE INHIBITOR -INDUCED APOPTOSIS (Conference Paper)
Forchap, S. L., Pirmohamed, M., & Clark, R. E. (2009). RELEASE OF INTRACELLULAR CALCIUM PRIMES CHRONIC MYELOID LEUKAEMIA CELLS FOR TYROSINE KINASE INHIBITOR -INDUCED APOPTOSIS. In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL Vol. 94 (pp. 257). Retrieved from http://gateway.webofknowledge.com/
Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers (Journal article)
Musumba, C., Pritchard, D. M., & Pirmohamed, M. (2009). Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 30(6), 517-531. doi:10.1111/j.1365-2036.2009.04086.x
DOI: 10.1111/j.1365-2036.2009.04086.x
Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1 (Journal article)
Megherbi, R., Kiorpelidou, E., Foster, B., Rowe, C., Naisbitt, D. J., Goldring, C. E., & Park, B. K. (2009). Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1. Toxicology and Applied Pharmacology, 238(2), 120-132. doi:10.1016/j.taap.2009.05.001
DOI: 10.1016/j.taap.2009.05.001
Role of reactive metabolites in drug-induced hepatotoxicity (Chapter)
Srivasta, A., Maggs, J. L., Antoine, D. J., Williams, D. P., Smith, D. A., & Park, B. K. (2009). Role of reactive metabolites in drug-induced hepatotoxicity. In J. Uetrecht (Ed.), Adverse Drug Reactions (pp. 165-194). London: Springer Heidelberg Dordrecht.
S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility (Journal article)
Nedjadi, T., Kitteringham, N., Campbell, F., Jenkins, R. E., Park, B. K., Navarro, P., . . . Costello, E. (2009). S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. BRITISH JOURNAL OF CANCER, 101(7), 1145-1154. doi:10.1038/sj.bjc.6605289
Stimulation of antigen-specific T-cells from allergic patients with sulfonamides and sulfonamide metabolites (Conference Paper)
Casterjon, J. L., Jenkinson, C., Gerber, B. O., Pichler, W. J., Park, B. K., & Naisbitt, D. J. (2009). Stimulation of antigen-specific T-cells from allergic patients with sulfonamides and sulfonamide metabolites. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 289-290). Retrieved from http://gateway.webofknowledge.com/
Spontaneous Hemothorax Following Anticoagulation with Low-Molecular-Weight Heparin (Journal article)
Ganguli, A., Walker, L., FitzGerald, R. J., & Pirmohamed, M. (2009). Spontaneous Hemothorax Following Anticoagulation with Low-Molecular-Weight Heparin. ANNALS OF PHARMACOTHERAPY, 43(9), 1528-1531. doi:10.1345/aph.1L542
Structural instability in an autophosphorylating kinase switch (Journal article)
Grinfeld, M., & Webb, S. D. (2009). Structural instability in an autophosphorylating kinase switch. Mathematical Biosciences, 219(2), 92-96. doi:10.1016/j.mbs.2009.02.005
DOI: 10.1016/j.mbs.2009.02.005
Sulfamethoxazole metabolism by mouse splenocytes creates T-cell stimulatory hapten-protein complexes (Conference Paper)
Elsheikh, A., Castrejon, J. L., Lavergne, S. N., Park, B. K., & Naisbitt, D. J. (2009). Sulfamethoxazole metabolism by mouse splenocytes creates T-cell stimulatory hapten-protein complexes. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 288). Retrieved from http://gateway.webofknowledge.com/
Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P-falciparum malaria parasites and HL-60 cancer cells (Journal article)
Chadwick, J., Mercer, A. E., Park, B. K., Cosstick, R., & O'Neill, P. M. (2009). Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P-falciparum malaria parasites and HL-60 cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY, 17(3), 1325-1338. doi:10.1016/j.bmc.2008.12.017
DOI: 10.1016/j.bmc.2008.12.017
O'Neill, P. M., Shone, A. E., Stanford, D., Nixon, G., Asadollahy, E., Park, B. K., . . . Ward, S. A. (2009). Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4 '-Fluoro and 4 '-Chloro Analogues of Amodiaquine. Identification of a Suitable "Back-Up" Compound for N-tert-Butyl Isoquine. JOURNAL OF MEDICINAL CHEMISTRY, 52(7), 1828-1844. doi:10.1021/jm8012757
TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole (Journal article)
Alfirevic, A., Vilar, F. J., Alsbou, M., Jawaid, A., Thomson, W., Ollier, W. E. R., . . . Pirmohamed, M. (2009). TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole. PHARMACOGENOMICS, 10(4), 531-540. doi:10.2217/PGS.09.6
The applications of pharmacogenetics to prescribing: what is currently practicable? (Journal article)
Pirmohamed, M. (2009). The applications of pharmacogenetics to prescribing: what is currently practicable?. CLINICAL MEDICINE, 9(5), 493-495. doi:10.7861/clinmedicine.9-5-493
DOI: 10.7861/clinmedicine.9-5-493
The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy (Journal article)
Adetunji, O. R., MacFarlane, I. A., Javadpour, M., Alfirevic, A., Pirmohamed, M., & Blair, J. C. (2009). The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 161(4), 541-546. doi:10.1530/EJE-09-0405
The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC (Journal article)
Liptrott, N. J., Penny, M., Bray, P. G., Sathish, J., Khoo, S. H., Back, D. J., & Owen, A. (2009). The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC. BRITISH JOURNAL OF PHARMACOLOGY, 156(3), 497-508. doi:10.1111/j.1476-5381.2008.00050.x
DOI: 10.1111/j.1476-5381.2008.00050.x
The multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: Implications for hapten formation, structure and stability (Conference Paper)
Callan, H. E., Jenkins, R. E., Maggs, J. L., Lavergne, S. N., Naisbitt, D. J., & Park, B. K. (2009). The multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: Implications for hapten formation, structure and stability. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 288-289). Retrieved from http://gateway.webofknowledge.com/
The role of bioactivation in the pharmacology and toxicology of the artemisinin-based antimalarials (Journal article)
Mercer, A. E. (2009). The role of bioactivation in the pharmacology and toxicology of the artemisinin-based antimalarials. CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 12(1), 125-132. Retrieved from http://gateway.webofknowledge.com/
The role of metabolism in T-cell mediated drug hypersensitivity reactions (Journal article)
Naisbitt, D. (2009). The role of metabolism in T-cell mediated drug hypersensitivity reactions. TOXICOLOGY LETTERS, 189, S170-S171. doi:10.1016/j.toxlet.2009.06.698
DOI: 10.1016/j.toxlet.2009.06.698
Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis (Journal article)
Mellberg, S., Dimberg, A., Bahram, F., Hayashi, M., Rennel, E., Ameur, A., . . . Claesson-Welsh, L. (2009). Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis. The FASEB Journal, 23(5), 1490-1502. doi:10.1096/fj.08-123810
Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells. (Journal article)
Ignatova, I. D., Kostadinova, R. M., Goldring, C. E., Nawrocki, A. R., Frey, F. J., & Frey, B. M. (2009). Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells.. Am J Physiol Endocrinol Metab.