2014
A metabolomic profiling study of a chemically-induced mouse model of intestinal inflammation (Conference Paper)
Reade, S., Duckworth, C. A., Khalid, T., Mayor, A., Aggio, R., Pritchard, D. M., & Probert, C. S. (2014). A METABOLOMIC PROFILING STUDY OF A CHEMICALLY-INDUCED MOUSE MODEL OF INTESTINAL INFLAMMATION. In GUT Vol. 63 (pp. A172). doi:10.1136/gutjnl-2014-307263.369
DOI: 10.1136/gutjnl-2014-307263.369
A Review of A Priori Regression Models for Warfarin Maintenance Dose Prediction (Journal article)
Francis, B., Lane, S., Pirmohamed, M., & Jorgensen, A. (2014). A Review of A Priori Regression Models for Warfarin Maintenance Dose Prediction. PLOS ONE, 9(12). doi:10.1371/journal.pone.0114896
DOI: 10.1371/journal.pone.0114896
A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine (Journal article)
Raedisch, S., Dickens, D., Lang, T., Bonnett, L., Arlanov, R., Johnson, M. R., . . . Pirmohamed, M. (2014). A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine. PHARMACOGENOMICS JOURNAL, 14(5), 481-487. doi:10.1038/tpj.2014.5
A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy (Journal article)
Speed, D., Hoggart, C., Petrovski, S., Tachmazidou, I., Coffey, A., Jorgensen, A., . . . Johnson, M. R. (2014). A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. HUMAN MOLECULAR GENETICS, 23(1), 247-258. doi:10.1093/hmg/ddt403
Abacavir Forms Novel Cross-Linking Abacavir Protein Adducts in Patients (Journal article)
Meng, X., Lawrenson, A. S., Berry, N. G., Maggs, J. L., French, N. S., Back, D. J., . . . Park, B. K. (2014). Abacavir Forms Novel Cross-Linking Abacavir Protein Adducts in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 27(4), 524-535. doi:10.1021/tx400406p
ADRIC: Adverse Drug Reactions In Children – a programme of research using mixed methods (Journal article)
Smyth, R. L., Peak, M., Turner, M. A., Nunn, A. J., Williamson, P. R., Young, B., . . . Pirmohamed, M. (2014). ADRIC: Adverse Drug Reactions In Children – a programme of research using mixed methods. Programme Grants for Applied Research, 2(3), 1-184. doi:10.3310/pgfar02030
Abs No: HLA-A*31:01 positive hypersensitive patient (Journal article)
Lichtenfels, M., Farrell, J., Ogese, M., Bell, C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). Abs No: HLA-A*31:01 positive hypersensitive patient.. Clinical and translational allergy, 4(Suppl 3), P117. doi:10.1186/2045-7022-4-S3-P117
DOI: 10.1186/2045-7022-4-S3-P117
Adverse Drug Reactions (Chapter)
Walker, L., Yip, V., & Pirmohamed, M. (2014). Adverse Drug Reactions. In Handbook of Pharmacogenomics and Stratified Medicine (pp. 405-435). doi:10.1016/B978-0-12-386882-4.00020-7
DOI: 10.1016/B978-0-12-386882-4.00020-7
Adverse drug reactions: From man to molecule and back again (Conference Paper)
Park, B. K. (2014). Adverse drug reactions: From man to molecule and back again. In TOXICOLOGY LETTERS Vol. 229 (pp. S2-S3). doi:10.1016/j.toxlet.2014.07.013
DOI: 10.1016/j.toxlet.2014.07.013
Adverse drug reactions and off-label and unlicensed medicines in children: a prospective cohort study of unplanned admissions to a paediatric hospital (Journal article)
Bellis, J. R., Kirkham, J. J., Nunn, A. J., & Pirmohamed, M. (2014). Adverse drug reactions and off-label and unlicensed medicines in children: a prospective cohort study of unplanned admissions to a paediatric hospital. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 77(3), 545-553. doi:10.1111/bcp.12222
Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations (Journal article)
Gonzalez-Galarza, F. F., Takeshita, L. Y. C., Santos, E. J. M., Kempson, F., Thomaz Maia, M. H., Soares da Silva, A. L., . . . Middleton, D. (2015). Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations. NUCLEIC ACIDS RESEARCH, 43(D1), D784-D788. doi:10.1093/nar/gku1166
Antigen exposure required for T cell activation (Journal article)
Meng, X., Yaseen, F., Earnshaw, C., Jenkins, R., Peckham, D., Whitaker, P., . . . Park, K. (2014). Antigen exposure required for T cell activation.. Clinical and translational allergy, 4(Suppl 3), P115. doi:10.1186/2045-7022-4-S3-P115
DOI: 10.1186/2045-7022-4-S3-P115
Assessing the reliability of exome sequencing to detect the filaggrin null mutations R501X and 2282del4 (Conference Paper)
Thompson, B., Hawcutt, D., Carr, D., Bloch, K., Swale, A., Smyth, R., & Pirmohamed, M. (2014). Assessing the reliability of exome sequencing to detect the filaggrin null mutations R501X and 2282del4. In BRITISH JOURNAL OF DERMATOLOGY Vol. 171 (pp. 115-116). Retrieved from http://gateway.webofknowledge.com/
Baclofen as an adjunct pharmacotherapy for the maintenance of abstinence in alcohol dependent patients with liver disease (Conference Paper)
Owens, L., Richardson, P., Pirmohamed, M., & Rose, A. (2014). BACLOFEN AS AN ADJUNCT PHARMACOTHERAPY FOR THE MAINTENANCE OF ABSTINENCE IN ALCOHOL DEPENDENT PATIENTS WITH LIVER DISEASE. In GUT Vol. 63 (pp. A90-A91). doi:10.1136/gutjnl-2014-307263.192
DOI: 10.1136/gutjnl-2014-307263.192
Biomarkers Distinguish Apoptotic and Necrotic Cell Death During Hepatic Ischemia/Reperfusion Injury in Mice (Journal article)
Yang, M., Antoine, D. J., Weemhoff, J. L., Jenkins, R. E., Farhood, A., Park, B. K., & Jaeschke, H. (2014). Biomarkers Distinguish Apoptotic and Necrotic Cell Death During Hepatic Ischemia/Reperfusion Injury in Mice. LIVER TRANSPLANTATION, 20(11), 1372-1382. doi:10.1002/lt.23958
Blood Kidney Injury Molecule-1 Is a Biomarker of Acute and Chronic Kidney Injury and Predicts Progression to ESRD in Type I Diabetes (Journal article)
Sabbisetti, V. S., Waikar, S. S., Antoine, D. J., Smiles, A., Wang, C., Ravisankar, A., . . . Bonventre, J. V. (2014). Blood Kidney Injury Molecule-1 Is a Biomarker of Acute and Chronic Kidney Injury and Predicts Progression to ESRD in Type I Diabetes. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 25(10), 2177-2186. doi:10.1681/ASN.2013070758
Clinical Pharmacogenomics (Conference Paper)
Pirmohamed, M. (2014). CLINICAL PHARMACOGENOMICS. In DRUG METABOLISM REVIEWS Vol. 45 (pp. 4). Retrieved from http://gateway.webofknowledge.com/
CYP2B6 c.983T > C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations (Journal article)
Carr, D. F., Chaponda, M., Castro, E. M. C., Jorgensen, A. L., Khoo, S., Van Oosterhout, J. J., . . . Pirmohamed, M. (2014). CYP2B6 c.983T > C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 69(12), 3329-3334. doi:10.1093/jac/dku315
CYP2B6*18 is associated with nevirpine hypersensitivity independently of HLA-C*04:01 in a Malawian HIV population (Journal article)
Carr, D., Chaponda, M., Castro, E. C., Jorgensen, A., Khoo, S., & Pirmohamed, M. (2014). CYP2B6*18 is associated with nevirpine hypersensitivity independently of HLA-C*04:01 in a Malawian HIV population.. Clinical and translational allergy, 4(Suppl 3), P126. doi:10.1186/2045-7022-4-S3-P126
DOI: 10.1186/2045-7022-4-S3-P126
Calprotectin and Lactoferrin Faecal Levels in Patients with Clostridium difficile Infection (CDI): A Prospective Cohort Study (Journal article)
Swale, A., Miyajima, F., Roberts, P., Hall, A., Little, M., Beadsworth, M. B. J., . . . Pirmohamed, M. (2014). Calprotectin and Lactoferrin Faecal Levels in Patients with Clostridium difficile Infection (CDI): A Prospective Cohort Study. PLOS ONE, 9(8). doi:10.1371/journal.pone.0106118
DOI: 10.1371/journal.pone.0106118
Cardiovascular Pharmacogenomics: Expectations and Practical Benefits (Journal article)
Turner, R. M., & Pirmohamed, M. (2014). Cardiovascular Pharmacogenomics: Expectations and Practical Benefits. CLINICAL PHARMACOLOGY & THERAPEUTICS, 95(3), 281-293. doi:10.1038/clpt.2013.234
Characterization of amoxicillin and clavulanic-acid-responsive CD4+ And CD8+ T-cells in patients with co-amoxiclav-induced liver injury (Journal article)
Kim, S. -H., Saide, K., Yuan, Y., Daly, A., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. (2014). Characterization of amoxicillin and clavulanic-acid-responsive CD4+ And CD8+ T-cells in patients with co-amoxiclav-induced liver injury.. Clinical and translational allergy, 4(Suppl 3), P42. doi:10.1186/2045-7022-4-S3-P42
DOI: 10.1186/2045-7022-4-S3-P42
Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase (Journal article)
Ogese, M. O., Jenkins, R. E., Maggs, J. L., Meng, X., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2015). Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase. CHEMICAL RESEARCH IN TOXICOLOGY, 28(1), 144-154. doi:10.1021/tx500458k
Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids (Journal article)
Copple, I. M., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., . . . Park, B. K. (2014). Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids. TOXICOLOGICAL SCIENCES, 140(2), 462-469. doi:10.1093/toxsci/kfu080
Chronic intravenous infusion as a model to investigate mechanisms of toxicity (Conference Paper)
Norton, A. M., Clarke, J. I., McCarthy, A., Williams, D. P., & Park, B. K. (2014). Chronic intravenous infusion as a model to investigate mechanisms of toxicity. In TOXICOLOGY LETTERS Vol. 229 (pp. S46). doi:10.1016/j.toxlet.2014.06.200
DOI: 10.1016/j.toxlet.2014.06.200
Chen, C., Duckworth, C. A., Fu, B., Pritchard, D. M., Rhodes, J. M., & Yu, L. -G. (2014). Circulating galectins-2,-4 and-8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis. BRITISH JOURNAL OF CANCER, 110(3), 741-752. doi:10.1038/bjc.2013.793
Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing: 2014 Update (Journal article)
Martin, M. A., Hoffman, J. M., Freimuth, R. R., Klein, T. E., Dong, B. J., Pirmohamed, M., . . . Kroetz, D. L. (2014). Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing: 2014 Update. CLINICAL PHARMACOLOGY & THERAPEUTICS, 95(5), 499-500. doi:10.1038/clpt.2014.38
Clinical coding of prospectively identified paediatric adverse drug reactions - a retrospective review of patient records (Journal article)
Bellis, J. R., Kirkham, J. J., Nunn, A. J., & Pirmohamed, M. (2014). Clinical coding of prospectively identified paediatric adverse drug reactions - a retrospective review of patient records. BMC PHARMACOLOGY & TOXICOLOGY, 15. doi:10.1186/2050-6511-15-72
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles (Journal article)
Goldstein, J. I., Jarskog, L. F., Hilliard, C., Alfirevic, A., Duncan, L., Fourches, D., . . . Sullivan, P. F. (2014). Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. NATURE COMMUNICATIONS, 5. doi:10.1038/ncomms5757
Corrigendum: Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy (Journal article)
Corrigendum: Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy (2014). Clinical Pharmacology & Therapeutics, 96(3), 397. doi:10.1038/clpt.2014.142
Cost-Effectiveness of Pharmacogenetics-Guided Warfarin Therapy vs. Alternative Anticoagulation in Atrial Fibrillation (Journal article)
Pink, J., Pirmohamed, M., Lane, S., & Hughes, D. A. (2014). Cost-Effectiveness of Pharmacogenetics-Guided Warfarin Therapy vs. Alternative Anticoagulation in Atrial Fibrillation. CLINICAL PHARMACOLOGY & THERAPEUTICS, 95(2), 199-207. doi:10.1038/clpt.2013.190
Covalent adduction of carbamazepine 10, 11-epoxide with human serum albumin and glutathione S-transferase pi: implications for carbamazepine hypersensitivity (Journal article)
Yip, V., Maggs, J., Meng, X., Marson, A., Park, K., & Pirmohamed, M. (2014). Covalent adduction of carbamazepine 10, 11-epoxide with human serum albumin and glutathione S-transferase pi: implications for carbamazepine hypersensitivity. LANCET, 383, 114. Retrieved from http://gateway.webofknowledge.com/
Deletion of specific NF-κB proteins regulates susceptibility to colitis associated adenoma development in C57BL/6 mice as a result of altered inflammatory and DNA damage responses (Journal article)
Burkitt, M. D., Hanedi, A., Duckworth, C. A., Williams, J. M., Dimaline, R., Caamano, J., & Pritchard, D. M. (2014). Deletion of specific NF-κB proteins regulates susceptibility to colitis associated adenoma development in C57BL/6 mice as a result of altered inflammatory and DNA damage responses. PLOS Genetics.
Development of predictive genetic tests for improving the safety of new medicines: the utilization of routinely collected electronic health records (Journal article)
Wing, K., Douglas, I., Bhaskaran, K., Klungel, O. H., Reynolds, R. F., Pirmohamed, M., . . . van Staa, T. P. (2014). Development of predictive genetic tests for improving the safety of new medicines: the utilization of routinely collected electronic health records. DRUG DISCOVERY TODAY, 19(4), 361-366. doi:10.1016/j.drudis.2013.11.003
DOI: 10.1016/j.drudis.2013.11.003
Development, validation and clinical application of a novel method for the quantification of efavirenz in dried breast milk spots using LC-MS/MS (Journal article)
Olagunju, A., Bolaji, O. O., Amara, A., Waitt, C., Else, L., Soyinka, J., . . . Khoo, S. (2015). Development, validation and clinical application of a novel method for the quantification of efavirenz in dried breast milk spots using LC-MS/MS. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 70(2), 555-561. doi:10.1093/jac/dku420
Dexamethasone and haemorrhage risk in paediatric tonsillectomy: a systematic review and meta-analysis (Journal article)
Bellis, J. R., Pirmohamed, M., Nunn, A. J., Loke, Y. K., De, S., Golder, S., & Kirkham, J. J. (2014). Dexamethasone and haemorrhage risk in paediatric tonsillectomy: a systematic review and meta-analysis. BRITISH JOURNAL OF ANAESTHESIA, 113(1), 23-42. doi:10.1093/bja/aeu152
Dual Glutathione-S-Transferase-theta 1 and -mu 1 Gene Deletions Determine Imatinib Failure in Chronic Myeloid Leukemia (Journal article)
Davies, A., Giannoudis, A., Zhang, J. E., Austin, G., Wang, L., Holyoake, T. L., . . . Clark, R. E. (2014). Dual Glutathione-S-Transferase-theta 1 and -mu 1 Gene Deletions Determine Imatinib Failure in Chronic Myeloid Leukemia. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(6), 694-703. doi:10.1038/clpt.2014.176
Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis (Journal article)
Dear, J. W., Antoine, D. J., Starkey-Lewis, P., Goldring, C. E., & Park, B. K. (2014). Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 77(5), 904-905. doi:10.1111/bcp.12214
Electronic health records for biological sample collection: feasibility study of statin- induced myopathy using the Clinical Practice Research Datalink (Journal article)
O'Meara, H., Carr, D. F., Evely, J., Hobbs, M., McCann, G., van Staa, T., & Pirmohamed, M. (2014). Electronic health records for biological sample collection: feasibility study of statin- induced myopathy using the Clinical Practice Research Datalink. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 77(5), 831-838. doi:10.1111/bcp.12269
Endoplasmic Reticulum Resident Protein 44 (ERp44) Deficiency in Mice and Zebrafish Leads to Cardiac Developmental and Functional Defects (Journal article)
Wang, D. -Y., Abbasi, C., El-Rass, S., Li, J. Y., Dawood, F., Naito, K., . . . Gramolini, A. O. (2014). Endoplasmic Reticulum Resident Protein 44 (ERp44) Deficiency in Mice and Zebrafish Leads to Cardiac Developmental and Functional Defects. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 3(5). doi:10.1161/JAHA.114.001018
Establishment of an HLA-typed cohort of 1000 healthy blood donors and use of a dendritic cell priming assay to prime naive T cells to structurally divergent drugs (Journal article)
Faulkner, L., Wood, S., Van Eker, D., Alfirevic, A., Pirmohamed, M., Naisbitt, D., & Park, K. (2014). Establishment of an HLA-typed cohort of 1000 healthy blood donors and use of a dendritic cell priming assay to prime naive T cells to structurally divergent drugs.. Clinical and translational allergy, 4(Suppl 3), P112. doi:10.1186/2045-7022-4-S3-P112
DOI: 10.1186/2045-7022-4-S3-P112
Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist (Journal article)
Thaventhiran, T., Alhumeed, N., Yeang, H. X. A., Sethu, S., Downey, J. S., Alghanem, A. F., . . . Sathish, J. G. (2014). Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist. MABS, 6(5), 1290-1299. doi:10.4161/mabs.29758
Folate Augmentation of Treatment-Evaluation for Depression (FolATED): randomised trial and economic evaluation (Journal article)
Bedson, E., Bell, D., Carr, D., Carter, B., Hughes, D., Jorgensen, A., . . . Trialists, F. (2014). Folate Augmentation of Treatment-Evaluation for Depression (FolATED): randomised trial and economic evaluation. HEALTH TECHNOLOGY ASSESSMENT, 18(48), 1-+. doi:10.3310/hta18480
GATM gene variants and statin myopathy risk (Journal article)
Carr, D. F., Alfirevic, A., Johnson, R., Chinoy, H., van Staa, T., & Pirmohamed, M. (2014). GATM gene variants and statin myopathy risk. NATURE, 513(7518), E1. doi:10.1038/nature13628
Middleton, G., Silcocks, P., Cox, T., Valle, J., Wadsley, J., Propper, D., . . . Neoptolemos, J. (2014). Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial. LANCET ONCOLOGY, 15(8), 829-840. doi:10.1016/S1470-2045(14)70236-0
DOI: 10.1016/S1470-2045(14)70236-0
Genetics of Immune-Mediated Adverse Drug Reactions: a Comprehensive and Clinical Review (Journal article)
Yip, V. L. M., Alfirevic, A., & Pirmohamed, M. (2015). Genetics of Immune-Mediated Adverse Drug Reactions: a Comprehensive and Clinical Review. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 48(2-3), 165-175. doi:10.1007/s12016-014-8418-y
DOI: 10.1007/s12016-014-8418-y
Genome-wide association study of nevirapine hypersensitivity in a Malawian HIV-infected population (Journal article)
Carr, D., Bourgeois, S., Chaponda, M., Castro, E. C., Deloukas, P., & Pirmohamed, M. (2014). Genome-wide association study of nevirapine hypersensitivity in a malawian HIV-infected population.. Clinical and translational allergy, 4(Suppl 3), P125. doi:10.1186/2045-7022-4-S3-P125
DOI: 10.1186/2045-7022-4-S3-P125
Genotype-Guided Dosing of Vitamin K Antagonists REPLY (Journal article)
Maitland-van der Zee, A. H., de Boer, A., Manolopoulos, V. G., & Grp, E. U. -P. A. C. T. (2014). Genotype-Guided Dosing of Vitamin K Antagonists REPLY. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1765-1766. Retrieved from http://gateway.webofknowledge.com/
Genotype-Guided Vitamin K Antagonist Dosing Algorithms Improve Time in Therapeutic Range: A Systematic Review and Meta-Analysis (Conference Paper)
BeIley-Cote, E. P., Hanif, H., D'Aragon, F., Eikelboom, J., Anderson, J. L., Borgman, M., . . . Whitlock, R. (2014). Genotype-Guided Vitamin K Antagonist Dosing Algorithms Improve Time in Therapeutic Range: A Systematic Review and Meta-Analysis. In CIRCULATION Vol. 130. Retrieved from http://gateway.webofknowledge.com/
Genotype-guided dosing of vitamin K antagonists (Journal article)
Pereira, N. L., Rihal, C. S., & Weinshilboum, R. M. (2014). Genotype-guided dosing of vitamin K antagonists.. The New England journal of medicine, 370(18), 1762. doi:10.1056/nejmc1402521
HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress (Journal article)
Zhang, L., Chen, X., Sharma, P., Moon, M., Sheftel, A. D., Dawood, F., . . . Liu, P. P. (2014). HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. NATURE COMMUNICATIONS, 5. doi:10.1038/ncomms4430
HLA Restriction of Carbamazepine-Specific T-Cell Clones from an HLA-A*31:01-Positive Hypersensitive Patient (Journal article)
Lichtenfels, M., Farrell, J., Ogese, M. O., Bell, C. C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). HLA Restriction of Carbamazepine-Specific T-Cell Clones from an HLA-A*31:01-Positive Hypersensitive Patient. CHEMICAL RESEARCH IN TOXICOLOGY, 27(2), 175-177. doi:10.1021/tx400460w
HLA restriction of carbamazepine-specific T-Cell clones from an HLA-A*31:01-positive hypersensitive patient. (Journal article)
Lichtenfels, M., Farrell, J., Ogese, M., Bell, C. C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). HLA restriction of carbamazepine-specific T-Cell clones from an HLA-A*31:01-positive hypersensitive patient.. Chemical Research in Toxicology, 27(2), 175-177.
HLA-DQ restricted activation of nitroso-sulfamethoxazole-specific CD4+ T-lymphocytes (Journal article)
Ogese, M., Saide, K., Whitaker, P., Peckham, D., Faulkner, L., Alfirevic, A., . . . Naisbitt, D. (2014). HLA-DQ restricted activation of nitroso-sulfamethoxazole-specific CD4+ T-lymphocytes.. Clinical and translational allergy, 4(Suppl 3), P110. doi:10.1186/2045-7022-4-S3-P110
DOI: 10.1186/2045-7022-4-S3-P110
Hemolytic anemia in two patients with glioblastoma multiforme: A possible interaction between vorinostat and dapsone (Journal article)
Lewis, J. A., Petty, W. J., Harmon, M., Peacock, J. E., Valente, K., Owen, J., . . . Lesser, G. J. (2015). Hemolytic anemia in two patients with glioblastoma multiforme: A possible interaction between vorinostat and dapsone. JOURNAL OF ONCOLOGY PHARMACY PRACTICE, 21(3), 220-223. doi:10.1177/1078155214524085
High mobility group box 1 in the inflammatory pathogenesis of epilepsy: profiling circulating levels after experimental and clinical seizures (Journal article)
Walker, L., Tse, K., Ricci, E., Thippeswamy, T., Sills, G. J., White, S. H., . . . Pirmohamed, M. (2014). High mobility group box 1 in the inflammatory pathogenesis of epilepsy: profiling circulating levels after experimental and clinical seizures. LANCET, 383, 105. Retrieved from http://gateway.webofknowledge.com/
Humanized anti-HMGB1 antibody therapy attenuates in vivo acetaminophen-induced liver injury (Conference Paper)
Lea, J., Lundback, P., Ottosson, L., Sharkey, J., Sowinska, A., Palmblad, K., . . . Antoine, D. (2014). Humanized anti-HMGB1 antibody therapy attenuates in vivo acetaminophen-induced liver injury. In TOXICOLOGY LETTERS Vol. 229 (pp. S69-S70). doi:10.1016/j.toxlet.2014.06.273
DOI: 10.1016/j.toxlet.2014.06.273
Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications (Journal article)
Walsh, J., Jenkins, R. E., Wong, M., Olayanju, A., Powell, H., Copple, I., . . . Park, B. K. (2014). Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications. JOURNAL OF PROTEOMICS, 108, 171-187. doi:10.1016/j.jprot.2014.05.007
DOI: 10.1016/j.jprot.2014.05.007
IDENTIFYING THE CAUSES OF PHARMACORESISTANT EPILEPSY THROUGH A GENOME-WIDE ASSOCIATION STUDY WITH PATHWAY AND NETWORK ANALYSIS: FROM COMPLEXITY TO COHERENCE TO CENTRALITY (Conference Paper)
Mirza, N., Jorgensen, A., Sills, G., Johnson, M., Pirmohamed, M., & Marson, A. G. (2014). IDENTIFYING THE CAUSES OF PHARMACORESISTANT EPILEPSY THROUGH A GENOME-WIDE ASSOCIATION STUDY WITH PATHWAY AND NETWORK ANALYSIS: FROM COMPLEXITY TO COHERENCE TO CENTRALITY. In EPILEPSIA Vol. 55 (pp. 10). Retrieved from http://gateway.webofknowledge.com/
Identification of susceptible HLA class II co-amoxiclav genotypes based on the analysis of drug-specific T-cells from patients with liver injury (Journal article)
Saide, K., Kim, S. -H., Yuan, Y., Daly, A., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. (2014). Identification of susceptible HLA class II co-amoxiclav genotypes based on the analysis of drug-specific T-cells from patients with liver injury.. Clinical and translational allergy, 4(Suppl 3), O3. doi:10.1186/2045-7022-4-S3-O3
DOI: 10.1186/2045-7022-4-S3-O3
Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality (Conference Paper)
Mirza, N., Sills, G., Jorgensen, A., Johnson, M., Pirmohamed, M., & Marson, A. G. (2014). Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality. In JOURNAL OF NEUROLOGY Vol. 261 (pp. S484-S485). Retrieved from http://gateway.webofknowledge.com/
In AF or VTE, warfarin dosing by genotype improved time in therapeutic range but not clinical outcomes (Journal article)
Pirmohamed, M., Burnside, G., & Eriksson, N. (2014). In AF or VTE, warfarin dosing by genotype improved time in therapeutic range but not clinical outcomes. ANNALS OF INTERNAL MEDICINE, 160(6). doi:10.7326/0003-4819-160-6-201403180-02009
DOI: 10.7326/0003-4819-160-6-201403180-02009
Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers (vol 314, pg 262, 2013) (Journal article)
Pellegrini, G., Lewis, P. J. S., Palmer, L., Hetzel, U., Goldring, C. E., Park, B. K., . . . Williams, D. P. (2014). Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers (vol 314, pg 262, 2013). TOXICOLOGY, 318, 69-71. doi:10.1016/j.tox.2014.02.005
DOI: 10.1016/j.tox.2014.02.005
Investigating the roles of lysosomal iron and reactive oxygen species in the onset of mitochondrial toxicity induced through endoperoxide antimalarial drugs (Conference Paper)
Firman, J., Cain, K., Park, B. K., MacFarlane, M., & Chadwick, A. (2014). Investigating the roles of lysosomal iron and reactive oxygen species in the onset of mitochondrial toxicity induced through endoperoxide antimalarial drugs. In TOXICOLOGY LETTERS Vol. 229 (pp. S61-S62). doi:10.1016/j.toxlet.2014.06.247
DOI: 10.1016/j.toxlet.2014.06.247
Is the Interleukin 8 Promoter Polymorphism rs4073/-251T > A Associated With Clostridium difficile Infection? (Journal article)
Miyajima, F., Swale, A., Zhang, J. E., Alfirevic, A., Little, M., Beeching, N. J., . . . Pirmohamed, M. (2014). Is the Interleukin 8 Promoter Polymorphism rs4073/-251T > A Associated With Clostridium difficile Infection?. CLINICAL INFECTIOUS DISEASES, 58(12), E148-E151. doi:10.1093/cid/ciu152
In Vitro Diagnosis of Delayed-type Drug Hypersensitivity Mechanistic Aspects and Unmet Needs (Journal article)
Naisbitt, D. J., Nattrass, R. G., & Ogese, M. O. (2014). In Vitro Diagnosis of Delayed-type Drug Hypersensitivity Mechanistic Aspects and Unmet Needs. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 34(3), 691-+. doi:10.1016/j.iac.2014.04.009
DOI: 10.1016/j.iac.2014.04.009
Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts (Journal article)
Thulin, P., Nordahl, G., Gry, M., Yimer, G., Aklillu, E., Makonnen, E., . . . Schuppe-Koistinen, I. (2014). Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts. LIVER INTERNATIONAL, 34(3), 367-378. doi:10.1111/liv.12322
Hammond, T. G., Meng, X., Jenkins, R. E., Maggs, J. L., Castelazo, A. S., Regan, S. L., . . . Williams, D. P. (2014). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 350(2), 387-402. doi:10.1124/jpet.114.215079
Mechanisms of Adverse Drug Reactions (Chapter)
Pirmohamed, M. (2014). Mechanisms of Adverse Drug Reactions. In Mann's Pharmacovigilance: Third Edition (pp. 463-487). doi:10.1002/9781118820186.ch30
DOI: 10.1002/9781118820186.ch30
MECHANISTIC BIOMARKERS OF DRUG-INDUCED LIVER AND KIDNEY INJURY (Conference Paper)
Park, B. K. (2014). MECHANISTIC BIOMARKERS OF DRUG-INDUCED LIVER AND KIDNEY INJURY. In DRUG METABOLISM REVIEWS Vol. 45 (pp. 13-14). Retrieved from http://gateway.webofknowledge.com/
MicroRNAs as potential circulating biomarkers of drug-induced liver injury: key current and future issues for translation to humans (Journal article)
Hornby, R. J., Lewis, P. S., Dear, J., Goldring, C., & Park, B. K. (2014). MicroRNAs as potential circulating biomarkers of drug-induced liver injury: key current and future issues for translation to humans. EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 7(3), 349-362. doi:10.1586/17512433.2014.904201
DOI: 10.1586/17512433.2014.904201
Ng, C. -S., Hasnat, A., Al Maruf, A., Ahmed, M. U., Pirmohamed, M., Day, C. P., . . . Daly, A. K. (2014). N-acetyltransferase 2 (NAT2) genotype as a risk factor for development of drug-induced liver injury relating to antituberculosis drug treatment in a mixed-ethnicity patient group. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 70(9), 1079-1086. doi:10.1007/s00228-014-1703-0
DOI: 10.1007/s00228-014-1703-0
Negative Regulation by PD-L1 during Drug-Specific Priming of IL-22-Secreting T Cells and the Influence of PD-1 on Effector T Cell Function (Journal article)
Gibson, A., Ogese, M., Sullivan, A., Wang, E., Saide, K., Whitaker, P., . . . Naisbitt, D. J. (2014). Negative Regulation by PD-L1 during Drug-Specific Priming of IL-22-Secreting T Cells and the Influence of PD-1 on Effector T Cell Function. JOURNAL OF IMMUNOLOGY, 192(6), 2611-2621. doi:10.4049/jimmunol.1302720
Pathway Analysis of Genetic Factors Associated with Spontaneous Preterm Birth and Pre-Labor Preterm Rupture of Membranes (Journal article)
Capece, A., Vasieva, O., Meher, S., Alfirevic, Z., & Alfirevic, A. (2014). Pathway Analysis of Genetic Factors Associated with Spontaneous Preterm Birth and Pre-Labor Preterm Rupture of Membranes. PLOS ONE, 9(9). doi:10.1371/journal.pone.0108578
DOI: 10.1371/journal.pone.0108578
Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy (Journal article)
Maitland-van der Zee, A. H., Daly, A. K., Kamali, F., Manolopoulous, V. G., Verhoef, T. I., Wadelius, M., . . . Grp, E. U. -P. A. C. T. S. (2014). Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(1), 15-17. doi:10.1038/clpt.2014.44
Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy (vol 96, pg 15, 2014) (Journal article)
Maitland-van der Zee, A. H., Daly, A. K., Kamali, F., Manolopoulous, V. G., Verhoef, T. I., Wadelius, M., . . . Pirmohamed, M. (2014). Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy (vol 96, pg 15, 2014). CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(3), 397. Retrieved from http://gateway.webofknowledge.com/
Personalized Pharmacogenomics: Predicting Efficacy and Adverse Drug Reactions (Journal article)
Pirmohamed, M. (2014). Personalized Pharmacogenomics: Predicting Efficacy and Adverse Drug Reactions. ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 15, 15, 349-370. doi:10.1146/annurev-genom-090413-025419
DOI: 10.1146/annurev-genom-090413-025419
Pharmacogenetics in the treatment of chronic lymphocytic leukemia: what does the future hold? (Journal article)
Johnson, G. G., Carr, D. F., Pirmohamed, M., & Pettitt, A. R. (2014). Pharmacogenetics in the treatment of chronic lymphocytic leukemia: what does the future hold?. PHARMACOGENOMICS, 15(7), 897-900. doi:10.2217/pgs.14.60
Pharmacogenetics of antiepileptic drug-induced hypersensitivity (Journal article)
Bloch, K. M., Sills, G. J., Pirmohamed, M., & Alfirevic, A. (2014). Pharmacogenetics of antiepileptic drug-induced hypersensitivity. PHARMACOGENOMICS, 15(6), 857-868. doi:10.2217/PGS.14.65
Pharmacogenetics of warfarin in a paediatric population: time in therapeutic range, initial and stable dosing and adverse effects (Journal article)
Hawcutt, D. B., Ghani, A. A., Sutton, L., Jorgensen, A., Zhang, E., Murray, M., . . . Pirmohamed, M. (2014). Pharmacogenetics of warfarin in a paediatric population: time in therapeutic range, initial and stable dosing and adverse effects.PHARMACOGENOMICS JOURNAL, 14(6), 542-548. doi:10.1038/tpj.2014.31
Pharmacogenomic signatures of response to etanercept therapy for psoriasis (Conference Paper)
Foulkes, A. C., Carr, D. F., Al-Sharqi, A., Parslew, R., Pirmohamed, M., Reynolds, N. J., . . . Warren, R. B. (2014). Pharmacogenomic signatures of response to etanercept therapy for psoriasis. In BRITISH JOURNAL OF DERMATOLOGY Vol. 171 (pp. E114-E115). Retrieved from http://gateway.webofknowledge.com/
Pharmacogenomics: Current State-of-the-Art (Journal article)
Carr, D. F., Alfirevic, A., & Pirmohamed, M. (2014). Pharmacogenomics: Current State-of-the-Art. GENES, 5(2), 430-443. doi:10.3390/genes5020430
Phenotype Standardization for Statin-Induced Myotoxicity (Journal article)
Alfirevic, A., Neely, D., Armitage, J., Chinoy, H., Cooper, R. G., Laaksonen, R., . . . Pirmohamed, M. (2014). Phenotype Standardization for Statin-Induced Myotoxicity. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(4), 470-476. doi:10.1038/clpt.2014.121
Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System (Journal article)
Wadelius, M., Marshall, S. E., Islander, G., Nordang, L., Karawajczyk, M., Yue, Q. -Y., . . . Palmer, C. N. A. (2014). Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(4), 477-481. doi:10.1038/clpt.2014.138
Predictors and outcomes of increases in creatine phosphokinase concentrations or rhabdomyolysis risk during statin treatment (Journal article)
van Staa, T. P., Carr, D. F., O'Meara, H., McCann, G., & Pirmohamed, M. (2014). Predictors and outcomes of increases in creatine phosphokinase concentrations or rhabdomyolysis risk during statin treatment. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 78(3), 649-659. doi:10.1111/bcp.12367
Proteomic Analysis of Human Fetal Atria and Ventricle (Journal article)
Lu, Z. Q., Sinha, A., Sharma, P., Kislinger, T., & Gramolini, A. O. (2014). Proteomic Analysis of Human Fetal Atria and Ventricle. JOURNAL OF PROTEOME RESEARCH, 13(12), 5869-5878. doi:10.1021/pr5007685
PWE-109 A Metabolomic Profiling Study Of A Chemically-induced Mouse Model Of Intestinal Inflammation (Conference Paper)
Reade, S., Duckworth, C. A., Khalid, T., Mayor, A., Aggio, R., Pritchard, D. M., & Probert, C. S. (2014). PWE-109 A Metabolomic Profiling Study Of A Chemically-induced Mouse Model Of Intestinal Inflammation. In Gut Vol. 63 (pp. A172).
Zhao, Q., Duckworth, C. A., Wang, W., Guo, X., Barrow, H., Pritchard, D. M., . . . Yu, L. -G. (2014). Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galectin-3 to promote metastasis by interaction with cancer-associated MUC1. CARCINOGENESIS, 35(12), 2815-2821. doi:10.1093/carcin/bgu216
Quantification of urinary mevalonic acid as a biomarker of HMG-CoA reductase activity by a novel translational LC-MS/MS method (Journal article)
Rodrigues, A. V. M., Maggs, J. L., McWilliam, S. J., Pirmohamed, M., Coen, M., Wilson, I. D., . . . Antoine, D. J. (2014). Quantification of urinary mevalonic acid as a biomarker of HMG-CoA reductase activity by a novel translational LC-MS/MS method. BIOANALYSIS, 6(7), 919-933. doi:10.4155/BIO.13.350
Reference intervals for urinary renal injury biomarkers KIM-1and NGAL in healthy children (Journal article)
McWilliam, S. J., Antoine, D. J., Sabbisetti, V., Pearce, R. E., Jorgensen, A. L., Lin, Y., . . . Pirmohamed, M. (2014). Reference intervals for urinary renal injury biomarkers KIM-1and NGAL in healthy children. BIOMARKERS IN MEDICINE, 8(10), 1189-1197. doi:10.2217/BMM.14.36
Reporting of drug induced depression and fatal and non-fatal suicidal behaviour in the UK from 1998 to 2011 (Journal article)
Thomas, K. H., Martin, R. M., Potokar, J., Pirmohamed, M., & Gunnell, D. (2014). Reporting of drug induced depression and fatal and non-fatal suicidal behaviour in the UK from 1998 to 2011. BMC PHARMACOLOGY & TOXICOLOGY, 15. doi:10.1186/2050-6511-15-54
Retro-Orbital Blood Acquisition Facilitates Circulating microRNA Measurement in Zebrafish with Paracetamol Hepatotoxicity (Journal article)
Vliegenthart, A. D. B., Lewis, P. S., Tucker, C. S., Del Pozo, J., Rider, S., Antoine, D. J., . . . Dear, J. W. (2014). Retro-Orbital Blood Acquisition Facilitates Circulating microRNA Measurement in Zebrafish with Paracetamol Hepatotoxicity. ZEBRAFISH, 11(3), 219-226. doi:10.1089/zeb.2013.0912
Safety biomarkers for drug-induced liver injury - current status and future perspectives (Journal article)
Antoine, D. J., Harrill, A. H., Watkins, P. B., & Park, B. K. (2014). Safety biomarkers for drug-induced liver injury - current status and future perspectives. TOXICOLOGY RESEARCH, 3(2), 75-85. doi:10.1039/c3tx50077b
Sepsis carries a high mortality among hospitalised adults in Malawi in the era of antiretroviral therapy scale-up: A longitudinal cohort study (Journal article)
Waitt, P. I., Mukaka, M., Goodson, P., SimuKonda, F. D., Waitt, C. J., Feasey, N., . . . Heyderman, R. S. (2015). Sepsis carries a high mortality among hospitalised adults in Malawi in the era of antiretroviral therapy scale-up: A longitudinal cohort study. JOURNAL OF INFECTION, 70(1), 11-19. doi:10.1016/j.jinf.2014.07.004
DOI: 10.1016/j.jinf.2014.07.004
Serum Mannose-Binding Lectin Concentration, but Not Genotype, Is Associated With Clostridium difficile Infection Recurrence: A Prospective Cohort Study (Journal article)
Swale, A., Miyajima, F., Kolamunnage-Dona, R., Roberts, P., Little, M., Beeching, N. J., . . . Pirmohamed, M. (2014). Serum Mannose-Binding Lectin Concentration, but Not Genotype, Is Associated With Clostridium difficile Infection Recurrence: A Prospective Cohort Study. CLINICAL INFECTIOUS DISEASES, 59(10), 1429-1436. doi:10.1093/cid/ciu666
Skewing of the TCR V repertoire in SMX-NO specific T cell responses (Journal article)
Faulkner, L., Lichtenfels, M., Esser, P., Martin, S., Alfirevic, A., Pirmohamed, M., . . . Park, K. (2014). Skewing of the TCR V repertoire in SMX-NO specific T cell responses.. Clinical and translational allergy, 4(Suppl 3), P114. doi:10.1186/2045-7022-4-S3-P114
DOI: 10.1186/2045-7022-4-S3-P114
Statins, Immunomodulation, and Infections: A Complex and Unresolved Relationship (Journal article)
Pirmohamed, M. (2014). Statins, Immunomodulation, and Infections: A Complex and Unresolved Relationship. CLINICAL INFECTIOUS DISEASES, 58(3), 357-358. doi:10.1093/cid/cit751
Stimulating macrophages to enhance liver regeneration (Conference Paper)
Stutchfield, B. M., Mackinnon, A. C., Antoine, D. J., Gow, D. J., Hughes, M., Jenkins, S. J., . . . Forbes, S. J. (2014). Stimulating macrophages to enhance liver regeneration. In BRITISH JOURNAL OF SURGERY Vol. 101 (pp. 14). Retrieved from http://gateway.webofknowledge.com/
Swelling-activated Cl- currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smoothmuscle cells (Journal article)
Liang, W., Huang, L., Zhao, D., He, J. Z., Sharma, P., Liu, J., . . . Backx, P. H. (2014). Swelling-activated Cl- currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smoothmuscle cells. JOURNAL OF HYPERTENSION, 32(2), 318-330. doi:10.1097/HJH.0000000000000013
DOI: 10.1097/HJH.0000000000000013
T cell responses to drugs and drug metabolites (Journal article)
Earnshaw, C. J., Pecaric-Petkovic, T., Park, B. K., & Naisbitt, D. J. (2014). T cell responses to drugs and drug metabolites.. EXS, 104, 137-163. doi:10.1007/978-3-0348-0726-5_10
DOI: 10.1007/978-3-0348-0726-5_10
The clinical significance of ABCC3 as an imatinib transporter in chronic myeloid leukaemia (Journal article)
Giannoudis, A., Davies, A., Harris, R. J., Lucas, C. M., Pirmohamed, M., & Clark, R. E. (2014). The clinical significance of ABCC3 as an imatinib transporter in chronic myeloid leukaemia. LEUKEMIA, 28(6), 1360-1363. doi:10.1038/leu.2014.38
The importance of hapten - protein complex formation in the development of drug allergy (Journal article)
Faulkner, L., Meng, X., Park, B. K., & Naisbitt, D. J. (2014). The importance of hapten - protein complex formation in the development of drug allergy. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 14(4), 293-300. doi:10.1097/ACI.0000000000000078
DOI: 10.1097/ACI.0000000000000078
The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records: evaluations of two exemplar trials (Journal article)
The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records: evaluations of two exemplar trials (2014). HEALTH TECHNOLOGY ASSESSMENT, 18(43), 1-+. Retrieved from http://gateway.webofknowledge.com/
The role of ERK5 in endothelial cell function (Journal article)
Nithianandarajah-Jones, G. N., Wilm, B., Goldring, C. E. P., Mueller, J., & Cross, M. J. (2014). The role of ERK5 in endothelial cell function. BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 1584-1589. doi:10.1042/BST20140276
Thiopurine monitoring in children with inflammatory bowel disease: a systematic review (Journal article)
Konidari, A., Anagnostopoulos, A., Bonnett, L. J., Pirmohamed, M., & El-Matary, W. (2014). Thiopurine monitoring in children with inflammatory bowel disease: a systematic review. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 78(3), 467-476. doi:10.1111/bcp.12365
Through a Glass Darkly: Economics and Personalised Medicine (Journal article)
Haycox, A., Pirmohamed, M., McLeod, C., Houten, R., & Richards, S. (2014). Through a Glass Darkly: Economics and Personalised Medicine. PHARMACOECONOMICS, 32(11), 1055-1061. doi:10.1007/s40273-014-0190-6
DOI: 10.1007/s40273-014-0190-6
Transforming Growth Factor-beta-Independent Role of Connective Tissue Growth Factor in the Development of Liver Fibrosis (Journal article)
Sakai, K., Jawaid, S., Sasaki, T., Bou-Gharios, G., & Sakai, T. (2014). Transforming Growth Factor-beta-Independent Role of Connective Tissue Growth Factor in the Development of Liver Fibrosis. AMERICAN JOURNAL OF PATHOLOGY, 184(10), 2611-2617. doi:10.1016/j.ajpath.2014.06.009
DOI: 10.1016/j.ajpath.2014.06.009
Treatment of paracetamol overdose: room for improvement? (Journal article)
Park, K., Antoine, D. J., & Pirmohamed, M. (2014). Treatment of paracetamol overdose: room for improvement?. LANCET, 383(9918), 672-674. doi:10.1016/S0140-6736(13)62303-X
DOI: 10.1016/S0140-6736(13)62303-X
Validation of a multigenic model to predict seizure control in newly treated epilepsy (Journal article)
Shazadi, K., Petrovski, S., Roten, A., Miller, H., Huggins, R. M., Brodie, M. J., . . . Sills, G. J. (2014). Validation of a multigenic model to predict seizure control in newly treated epilepsy. EPILEPSY RESEARCH, 108(10), 1797-1805. doi:10.1016/j.eplepsyres.2014.08.022
DOI: 10.1016/j.eplepsyres.2014.08.022
Which genetic pathways underlie pharmacoresistant epilepsy? (Conference Paper)
Mirza, N., Jorgensen, A., Sills, G., Johnson, M., Pirmohamed, M., & Marson, T. (2014). WHICH GENETIC PATHWAYS UNDERLIE PHARMACORESISTANT EPILEPSY?. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 85. doi:10.1136/jnnp-2014-309236.6
DOI: 10.1136/jnnp-2014-309236.6