2010
A Role for the Pregnane X Receptor in Flucloxacillin-Induced Liver Injury (Journal article)
Andrews, E., Armstrong, M., Tugwood, J., Swan, D., Glaves, P., Pirmohamed, M., . . . Daly, A. K. (2010). A Role for the Pregnane X Receptor in Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 51(5), 1656-1664. doi:10.1002/hep.23549
A systematic review of cost effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives (Journal article)
Verhoef, T. I., Redekop, W. K., Darba, J., Geitona, M., Hughes, D. A., Siebert, U., . . . Grp, E. U. -P. A. C. T. (2010). A systematic review of cost effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives. PHARMACOGENOMICS, 11(7), 989-1002. doi:10.2217/PGS.10.74
Acceptance of Biomarker-Based Tests for Application in Clinical Practice: Criteria and Obstacles (Journal article)
Pirmohamed, M. (2010). Acceptance of Biomarker-Based Tests for Application in Clinical Practice: Criteria and Obstacles. CLINICAL PHARMACOLOGY & THERAPEUTICS, 88(6), 862-866. doi:10.1038/clpt.2010.245
Acyl glucuronides: the good, the bad and the ugly (Journal article)
Regan, S. L., Maggs, J. L., Hammond, T. G., Lambert, C., Williams, D. P., & Park, B. K. (2010). Acyl glucuronides: the good, the bad and the ugly. Biopharmaceutics & Drug Disposition, 31(7), 367-395. doi:10.1002/bdd.720
Adverse drug reactions causing admission to a paediatric hospital: a pilot study (Journal article)
Gallagher, R. M., Bird, K. A., Mason, J. R., Peak, M., Williamson, P. R., Nunn, A. J., . . . Smyth, R. L. (2011). Adverse drug reactions causing admission to a paediatric hospital: a pilot study. Journal of Clinical Pharmacy and Therapeutics, 36(2), 194-199. doi:10.1111/j.1365-2710.2010.01194.x
DOI: 10.1111/j.1365-2710.2010.01194.x
Adverse reactions to Colistin in cystic fibrosis: dose-dependent toxicity or immune-mediated reactions? (Conference Paper)
Lavergne, S. N., Whitaker, P., Peckham, D., Conway, S., Gooi, J., Park, B. K., & Naisbitt, D. J. (2010). ADVERSE REACTIONS TO COLISTIN IN CYSTIC FIBROSIS: DOSE-DEPENDENT TOXICITY OR IMMUNE-MEDIATED REACTIONS?. In PEDIATRIC PULMONOLOGY (pp. 377). Retrieved from http://gateway.webofknowledge.com/
Altered plasma levels of nevirapine after commencing rifampicin-containing TB regimens in Malawi (Conference Paper)
Chaponda, M., Nyirenda, W., Watson, V., White, S., Van Oosterhout, J., Lalloo, D., . . . Khoo, S. (2010). Altered plasma levels of nevirapine after commencing rifampicin-containing TB regimens in Malawi. In HIV MEDICINE Vol. 11 (pp. 6). Retrieved from http://gateway.webofknowledge.com/
An insight into circulating drug-specific lymphocytes from cystic fibrosis patients with a history of delayed allergic reaction to antibacterials (Conference Paper)
Lavergne, S. N., Whitaker, P., Peckham, D., Conway, S., Gooi, J., Peckham, B. K., & Naisbitt, D. J. (2010). AN INSIGHT INTO CIRCULATING DRUG-SPECIFIC LYMPHOCYTES FROM CYSTIC FIBROSIS PATIENTS WITH A HISTORY OF DELAYED ALLERGIC REACTION TO ANTIBACTERIALS. In PEDIATRIC PULMONOLOGY (pp. 377). Retrieved from http://gateway.webofknowledge.com/
Correlation of HOCT1 M420DEL SNP with the clinical outcome of chronic myeloid leukaemia patients treated with Imatinib (Journal article)
Giannoudis, A., Wang, L., Xynarianos, G., Liloglou, T., Austin, G., Clark, J., . . . Clark, R. (2010). CORRELATION OF HOCT1 M420DEL SNP WITH THE CLINICAL OUTCOME OF CHRONIC MYELOID LEUKAEMIA PATIENTS TREATED WITH IMATINIB. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 95, 341. Retrieved from http://gateway.webofknowledge.com/
CYP4F2 genotype-phenotype correlation in human liver (Conference Paper)
Zhang, J. E., Jorgensen, A., Kline, K., Alfirevic, A., Zanger, U., & Pirmohamed, M. (2010). CYP4F2 genotype-phenotype correlation in human liver. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 297-298). Retrieved from http://gateway.webofknowledge.com/
Carbamazepine-induced hypersensitivity in Caucasians and genetic variability in the major histocompatibility complex (Conference Paper)
Alfirevic, A., Bourgeois, S., Jorgensen, A., Steen, K., Weetman, D., Park, B. K., . . . Pirmohamed, M. (2010). Carbamazepine-induced hypersensitivity in Caucasians and genetic variability in the major histocompatibility complex. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 298). Retrieved from http://gateway.webofknowledge.com/
Characterization of p-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein (Journal article)
Jenkinson, C., Jenkins, R. E., Aleksic, M., Pirmohamed, M., Naisbitt, D. J., & Park, B. K. (2010). Characterization of p-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(3), 732-742. doi:10.1038/jid.2009.271
Characterization of piperacillin-specific T-cell clones from hypersensitive patients with cystic fibrosis (Conference Paper)
El-Ghaiesh, S., Monshi, M., Jenkins, R., Meng, X., French, N., Whitaker, P., . . . Naisbitt, D. (2010). Characterization of piperacillin-specific T-cell clones from hypersensitive patients with cystic fibrosis. In IMMUNOLOGY Vol. 131 (pp. 117). Retrieved from http://gateway.webofknowledge.com/
Characterization of sulfamethoxazole metabolite-specific T-cell activation in patients with cystic fibrosis (Journal article)
Elsheikh, A., Whitaker, P., Peckham, D., Park, B. K., & Naisbitt, D. (2010). Characterization of sulfamethoxazole metabolite-specific T-cell activation in patients with cystic fibrosis. Journal of Cystic Fibrosis, 9(S1), S48.
Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer (Journal article)
Shaw, V. E., Naisbitt, D. J., Costello, E., Greenhalf, W., Park, B. K., Neoptolemos, J. P., & Middleton, G. W. (2010). Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer. EXPERT REVIEW OF VACCINES, 9(9), 1007-1016. doi:10.1586/ERV.10.92
Cytochrome P450 testing for prescribing antipsychotics in adults with schizophrenia: systematic review and meta-analyses (Journal article)
Fleeman, N., Dundar, Y., Dickson, R., Jorgensen, A., Pushpakom, S., McLeod, C., . . . Walley, T. (2011). Cytochrome P450 testing for prescribing antipsychotics in adults with schizophrenia: systematic review and meta-analyses. PHARMACOGENOMICS JOURNAL, 11(1), 1-14. doi:10.1038/tpj.2010.73
Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts - role of TGF 1 levels and RhoA activity (Journal article)
Blumbach, K., Zweers, M. C., Brunner, G., Peters, A. S., Schmitz, M., Schulz, J. -N., . . . Eckes, B. (2010). Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts - role of TGF 1 levels and RhoA activity. Journal of Cell Science, 123(22), 3872-3883. doi:10.1242/jcs.063024
Chadwick, J., Jones, M., Mercer, A. E., Stocks, P. A., Ward, S. A., Park, B. K., & O'Neill, P. M. (2010). Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines. BIOORGANIC & MEDICINAL CHEMISTRY, 18(7), 2586-2597. doi:10.1016/j.bmc.2010.02.035
DOI: 10.1016/j.bmc.2010.02.035
Detection of siRNA induced mRNA silencing by RT-qPCR: considerations for experimental design (Journal article)
Holmes, K., Williams, C. M., Chapman, E. A., & Cross, M. J. (2010). Detection of siRNA induced mRNA silencing by RT-qPCR: considerations for experimental design. BMC Research Notes, 3(1), 53. doi:10.1186/1756-0500-3-53
Development of a neutrophil cell culture system to define the sensitizing potential of chemical allergens that acquire protein reactivity through metabolism (Conference Paper)
Kiorpelidou, E., Foster, B. J., Goldring, C., Naisbitt, D. J., & Park, K. (2010). Development of a neutrophil cell culture system to define the sensitizing potential of chemical allergens that acquire protein reactivity through metabolism. In IMMUNOLOGY Vol. 131 (pp. 171-172). Retrieved from http://gateway.webofknowledge.com/
Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity. (Journal article)
Antoine, D. J., Williams, D. P., Kipar, A., Laverty, H., & Park, B. K. (2010). Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity.. Mol Med, 16(11-12), 479-490.
Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB (Journal article)
Chia, A. J., Goldring, C. E., Kitteringham, N. R., Wong, S. Q., Morgan, P., & Park, B. K. (2010). Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB. Biochemical Pharmacology, 80(3), 410-421. doi:10.1016/j.bcp.2010.04.004
DOI: 10.1016/j.bcp.2010.04.004
Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism (Journal article)
Elsheikh, A., Lavergne, S. N., Castrejon, J. L., Farrell, J., Wang, H., Sathish, J., . . . Naisbitt, D. J. (2010). Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism. JOURNAL OF IMMUNOLOGY, 185(11), 6448-6460. doi:10.4049/jimmunol.1000889
Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity (Journal article)
Park, B. K., Laverty, H., Srivastava, A., Antoine, D. J., Naisbitt, D., & Williams, D. P. (2011). Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity. CHEMICO-BIOLOGICAL INTERACTIONS, 192(1-2), 30-36. doi:10.1016/j.cbi.2010.09.011
DOI: 10.1016/j.cbi.2010.09.011
Drug Metabolite-Specific Lymphocyte Responses in Sulfamethoxazole Allergic Patients with Cystic Fibrosis (Journal article)
Lavergne, S. N., Whitaker, P., Peckham, D., Conway, S., Park, B. K., & Naisbitt, D. J. (2010). Drug Metabolite-Specific Lymphocyte Responses in Sulfamethoxazole Allergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 23(6), 1009-1011. doi:10.1021/tx100151v
Drug-drug interactions and adverse drug reactions: separating the wheat from the chaff (Journal article)
Pirmohamed, M. (2010). Drug-drug interactions and adverse drug reactions: separating the wheat from the chaff. WIENER KLINISCHE WOCHENSCHRIFT, 122(3-4), 62-64. doi:10.1007/s00508-010-1309-1
DOI: 10.1007/s00508-010-1309-1
DRUG HYPERSENSITIVITY (Chapter)
Naisbitt, D. J., Park, B. K., & Demoly, P. (2010). DRUG HYPERSENSITIVITY. In S. Holgate (Ed.), Allergy (pp. 200). London: Elsveier.
Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future (Journal article)
Alfirevic, A., & Pirmohamed, M. (2010). Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future. PHARMACOGENOMICS, 11(4), 497-499. doi:10.2217/PGS.10.12
Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future. (Journal article)
Alfirevic, A., & Pirmohamed, M. (2010). Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future.. Pharmacogenomics, 11(4), 497-499.
ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells (Journal article)
Roberts, O. L., Holmes, K., Muller, J., Cross, D. A. E., & Cross, M. J. (2010). ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells. Journal of Cell Science, 123(18), 3189-3200. doi:10.1242/jcs.072801
Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells (Journal article)
Martin, P., Riley, R., Thompson, P., Williams, D., Back, D., & Owen, A. (2010). Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells. ACTA PHARMACOLOGICA SINICA, 31(1), 51-65. doi:10.1038/aps.2009.187
Emergency re-admissions to hospital due to adverse drug reactions within 1 year of the index admission (Journal article)
Davies, E. C., Green, C. F., Mottram, D. R., Rowe, P. H., & Pirmohamed, M. (2010). Emergency re-admissions to hospital due to adverse drug reactions within 1 year of the index admission. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 70(5), 749-755. doi:10.1111/j.1365-2125.2010.03751.x
DOI: 10.1111/j.1365-2125.2010.03751.x
Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole hypersensitive patients with cystic fibrosis (Journal article)
Elsheikh, A., Monshi, M., Castrejon, J., Lavergne, S., Whitaker, P., Pichler, W. J., . . . Naisbitt, D. J. (2010). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole hypersensitive patients with cystic fibrosis. IMMUNOLOGY, 131, 145-146. Retrieved from http://gateway.webofknowledge.com/
Establishment of a HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions (Conference Paper)
Bell, C., Martinsson, K., Faulkner, L., Alfirevic, A., French, N., Tugwood, J., . . . Park, B. K. (2010). Establishment of a HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions. In IMMUNOLOGY Vol. 131 (pp. 125). Retrieved from http://gateway.webofknowledge.com/
Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening (Journal article)
Baxter, M. A., Rowe, C., Alder, J., Harrison, S., Hanley, K. P., Park, B. K., . . . Hanley, N. A. (2010). Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening. Stem Cell Research, 5(1), 4-22. doi:10.1016/j.scr.2010.02.002
DOI: 10.1016/j.scr.2010.02.002
Genetic analysis of thiopurine methyltransferase polymorphism in the Jordanian population (Journal article)
Hakooz, N., Arafat, T., Payne, D., Ollier, W., Pushpakom, S., Andrews, J., & Newman, W. (2010). Genetic analysis of thiopurine methyltransferase polymorphism in the Jordanian population. European Journal of Clinical Pharmacology, 66(10), 999-1003.
Genetic variability in drug metabolising enzymes as determinant of carbamazepine dose requirement in newly diagnosed epilepsy (Conference Paper)
Shazadi, K., Sills, G. J., Alfirevic, A., Pirmohamed, M., & Marson, A. G. (2010). GENETIC VARIABILITY IN DRUG METABOLISING ENZYMES AS DETERMINANT OF CARBAMAZEPINE DOSE REQUIREMENT IN NEWLY DIAGNOSED EPILEPSY. In EPILEPSIA Vol. 51 (pp. 32). Retrieved from http://gateway.webofknowledge.com/
Genetic Variants of ABCC10 Are Associated with Kidney Tubular Dysfunction in Patients Treated with Tenofovir-containing Regimens (Conference Paper)
Pushpakom, S., Liptrott, N. J., RodrÃguez-Nóvoa, S., Labarga, P., Soriano, V., Albalater, M., . . . Owen, A. (2010). Genetic Variants of ABCC10 Are Associated with Kidney Tubular Dysfunction in Patients Treated with Tenofovir-containing Regimens. In 17th Conference on Retroviruses and Opportunistic Infections (pp. 352). San Francisco: Conference on Retroviruses and Opportunistic Infections.
Genetic Risk Factors for ADRs (Conference Paper)
Pirmohamed, M. (2010). Genetic Risk Factors for ADRs. In DRUG METABOLISM REVIEWS Vol. 42 (pp. 2-3). Retrieved from http://gateway.webofknowledge.com/
HOCT1 M420 deleted transcript levels predict poor clinical outcome for Imatinib treated CML patients (Journal article)
Wang, L., Giannoudis, A., Austin, G., Liloglou, T., Xinarianos, G., Clark, J., . . . Clark, R. (2010). HOCT1 M420 DELETED TRANSCRIPT LEVELS PREDICT POOR CLINICAL OUTCOME FOR IMATINIB TREATED CML PATIENTS. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 95, 61. Retrieved from http://gateway.webofknowledge.com/
Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort (Journal article)
Carr, D. F., la Porte, C. J. L., Pirmohamed, M., Owen, A., & Cortes, C. P. (2010). Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 65(9), 1889-1893. doi:10.1093/jac/dkq260
Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury (Journal article)
Donaldson, P. T., Daly, A. K., Henderson, J., Graham, J., Pirmohamed, M., Bernal, W., . . . Aithal, G. P. (2010). Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury. JOURNAL OF HEPATOLOGY, 53(6), 1049-1053. doi:10.1016/j.jhep.2010.05.033
DOI: 10.1016/j.jhep.2010.05.033
Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins (Journal article)
O'Neill, P. M., Amewu, R. K., Nixon, G. L., ElGarah, F. B., Mungthin, M., Chadwick, J., . . . Ward, S. A. (2010). Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 49(33), 5693-5697. doi:10.1002/anie.201001026
Immunomodulatory therapies and the risk of opportunistic infections (Journal article)
Johnson, D. E., Smith, D. A., & Park, B. K. (2010). Immunomodulatory therapies and the risk of opportunistic infections. Current Opinion in Drug Discovery and Development, 13(1), 20-22.
Integrated systems for quantifying metabolite biomarkers of hepatic bioactivation in patients (Journal article)
Williams, D. P. (2010). Integrated systems for quantifying metabolite biomarkers of hepatic bioactivation in patients. Bioanalysis, 2(4), 693-697.
Integration of Genetic, Clinical, and INR Data to Refine Warfarin Dosing (Journal article)
Lenzini, P., Wadelius, M., Kimmel, S., Anderson, J. L., Jorgensen, A. L., Pirmohamed, M., . . . Gage, B. F. (2010). Integration of Genetic, Clinical, and INR Data to Refine Warfarin Dosing. CLINICAL PHARMACOLOGY & THERAPEUTICS, 87(5), 572-578. doi:10.1038/clpt.2010.13
Interpreting adverse drug reaction (ADR) reports as hospital patient safety incidents (Journal article)
Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2010). Interpreting adverse drug reaction (ADR) reports as hospital patient safety incidents. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 70(1), 102-108. doi:10.1111/j.1365-2125.2010.03671.x
DOI: 10.1111/j.1365-2125.2010.03671.x
Involvement of drug-specific CD4(+) and CD8(+) T-cells in trimethoprim-mediated hepatitis (Conference Paper)
El-Ghaiesh, S., Lavergne, S., Farrell, J., Syn, W., Pirmohamed, M., Park, K., & Naisbitt, D. (2010). Involvement of drug-specific CD4(+) and CD8(+) T-cells in trimethoprim-mediated hepatitis. In IMMUNOLOGY Vol. 131 (pp. 120). Retrieved from http://gateway.webofknowledge.com/
Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer (Journal article)
Tweedle, E. M., Khattak, I., Ang, C. W., Nedjadi, T., Jenkins, R., Park, B. K., . . . Costello, E. (2010). Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer.. Gut, 59(11), 1501-1510. doi:10.1136/gut.2009.196626
Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals (Journal article)
Coulter, E. M., Jenkinson, C., Farrell, J., Lavergne, S. N., Pease, C., White, A., . . . Naisbitt, D. J. (2010). Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(1), 161-174. doi:10.1038/jid.2009.187
Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors. (Journal article)
Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2010). Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.. Pharmacogenetics and Genomics, 21(5), 297-302.
Castrejon, J. L., Lavergne, S. N., El-Sheikh, A., Farrell, J., Maggs, J. L., Sabbani, S., . . . Naisbitt, D. J. (2010). Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives. CHEMICAL RESEARCH IN TOXICOLOGY, 23(1), 184-192. doi:10.1021/tx900329b
Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach (Journal article)
Rowe, C., Goldring, C. E. P., Kitteringham, N. R., Jenkins, R. E., Lane, B. S., Sanderson, C., . . . Park, B. K. (2010). Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach.. Journal of proteome research, 9(5), 2658-2668. doi:10.1021/pr1001687
P13.04 Exploring the clinical utility of faecal biomarkers to investigate Clostridium difficile infection (CDI) (Journal article)
Swale, A., Miyajima, F., Farragher, T., Roberts, P., Little, M., Beeching, N., . . . Pirmohamed, M. (2010). P13.04 Exploring the clinical utility of faecal biomarkers to investigate Clostridium difficile infection (CDI). Journal of Hospital Infection, 76, S42. doi:10.1016/S0195-6701(10)60141-7
DOI: 10.1016/S0195-6701(10)60141-7
Pericellular fibronectin is required for RhoA-dependent responses to cyclic strain in fibroblasts (Journal article)
Lutz, R., Sakai, T., & Chiquet, M. (2010). Pericellular fibronectin is required for RhoA-dependent responses to cyclic strain in fibroblasts. Journal of Cell Science, 123(9), 1511-1521. doi:10.1242/jcs.060905
Pharmaceuticals - Special Issue on Personalised Medicine (Book)
Sills, G., & Pirmohamed, M. (Eds.) (2010). Pharmaceuticals - Special Issue on Personalised Medicine. Basel: MDPI. Retrieved from http://www.mdpi.com/journal/pharmaceuticals/sections/
Pharmacogenetics and pharmacogenomics: practical applications in routine medical practice. (Journal article)
Maitland-van der Zee, A. H., & Alfirevic, A. (2010). Pharmacogenetics and pharmacogenomics: practical applications in routine medical practice.. Genome Medicine, 2(9), 69.
Pharmacogenetics in reproductive and perinatal medicine (Journal article)
Alfirevic, A., Alfirevic, Z., & Pirmohamed, M. (2010). Pharmacogenetics in reproductive and perinatal medicine. PHARMACOGENOMICS, 11(1), 65-79. doi:10.2217/PGS.09.153
Pharmacogenetics of idiosyncratic adverse drug reactions (Journal article)
Pirmohamed, M. (2010). Pharmacogenetics of idiosyncratic adverse drug reactions.. Handbook of experimental pharmacology, (196), 477-491. doi:10.1007/978-3-642-00663-0_17
DOI: 10.1007/978-3-642-00663-0_17
Pharmacogenomics: the importance of accurate phenotypes (Journal article)
Gurwitz, D., & Pirmohamed, M. (2010). Pharmacogenomics: the importance of accurate phenotypes. PHARMACOGENOMICS, 11(4), 469-470. doi:10.2217/PGS.10.41
Population pharmacokinetic and pharmacogenetic analysis of nevirapine in hypersensitive and tolerant HIV-infected patients from Malawi (Conference Paper)
Dickinson, L., Chaponda, M., Carr, D., van Oosterhout, J. J., Kumwenda, J., Lalloo, D. G., . . . Khoo, S. H. (2010). Population pharmacokinetic and pharmacogenetic analysis of nevirapine in hypersensitive and tolerant HIV-infected patients from Malawi.. In Journal of the International AIDS Society Vol. 13 (pp. P181). doi:10.1186/1758-2652-13-S4-P181
DOI: 10.1186/1758-2652-13-S4-P181
Proposal of a pharmacogenetic-based dosing algorithm for the induction of warfarin anticoagulation therapy in patients with thromboembolic disease (Conference Paper)
Avery, P., Pirmohamed, M., Jorgensen, A., & Kamali, F. (2010). Proposal of a pharmacogenetic-based dosing algorithm for the induction of warfarin anticoagulation therapy in patients with thromboembolic disease. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 291). Retrieved from http://gateway.webofknowledge.com/
Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway (Journal article)
Copple, I. M., Lister, A., Obeng, A. D., Kitteringham, N. R., Jenkins, R. E., Layfield, R., . . . Park, B. K. (2010). Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(22), 16782-16788. doi:10.1074/jbc.M109.096545
Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver (Journal article)
Kitteringham, N. R., Abdullah, A., Walsh, J., Randle, L., Jenkins, R. E., Sison, R., . . . Park, B. K. (2010). Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.. Journal of proteomics, 73(8), 1612-1631. doi:10.1016/j.jprot.2010.03.018
DOI: 10.1016/j.jprot.2010.03.018
Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (Journal article)
Srivastava, A., Lian, L. -Y., Maggs, J. L., Chaponda, M., Pirmohamed, M., Williams, D. P., & Park, B. K. (2010). Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries. DRUG METABOLISM AND DISPOSITION, 38(1), 122-132. doi:10.1124/dmd.109.028688
Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (vol 38, pg 122, 2010) (Journal article)
Srivastava, A., Lian, L. -Y., Maggs, J. L., Chaponda, M., Pirmohamed, M., Williams, D. P., & Park, B. K. (2010). Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (vol 38, pg 122, 2010). DRUG METABOLISM AND DISPOSITION, 38(7), 1259. doi:10.1124/dmd.38.7.1259
Randomized Controlled Trial: Lisinopril Reduces Proteinuria, Ammonia, and Renal Polypeptide Tubular Catabolism in Patients With Chronic Allograft Nephropathy (Journal article)
Amara, A. B., Sharma, A., Alexander, J. L., Alfirevic, A., Mohiuddin, A., Pirmohamed, M., . . . Rustom, R. (2010). Randomized Controlled Trial: Lisinopril Reduces Proteinuria, Ammonia, and Renal Polypeptide Tubular Catabolism in Patients With Chronic Allograft Nephropathy. TRANSPLANTATION, 89(1), 104-114. doi:10.1097/TP.0b013e3181bf13d9
DOI: 10.1097/TP.0b013e3181bf13d9
Role of reactive metabolites in drug-induced hepatotoxicity (Journal article)
Srivastava, A., Maggs, J. L., Antoine, D. J., Williams, D. P., Smith, D. A., & Park, B. K. (2010). Role of reactive metabolites in drug-induced hepatotoxicity.. Handbook of experimental pharmacology, (196), 165-194. doi:10.1007/978-3-642-00663-0_7
DOI: 10.1007/978-3-642-00663-0_7
Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells (Journal article)
Ang, C. W., Nedjadi, T., Sheikh, A. A., Tweedle, E. M., Tonack, S., Honap, S., . . . Costello, E. (2010). Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells.. Carcinogenesis, 31(9), 1541-1551. doi:10.1093/carcin/bgq137
Simultaneous determination of nilotinib, imatinib and its main metabolite (CGP-74588) in human plasma by ultra-violet high performance liquid chromatography (Journal article)
Davies, A., Hayes, A. K., Knight, K., Watmough, S. J., Pirmohamed, M., & Clark, R. E. (2010). Simultaneous determination of nilotinib, imatinib and its main metabolite (CGP-74588) in human plasma by ultra-violet high performance liquid chromatography. LEUKEMIA RESEARCH, 34(6), 702-707. doi:10.1016/j.leukres.2009.11.009
DOI: 10.1016/j.leukres.2009.11.009
Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells (Journal article)
Antoine, D. J., Srivastava, A., Pirmohamed, M., & Park, B. K. (2010). Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells. BIOCHEMICAL PHARMACOLOGY, 79(4), 647-654. doi:10.1016/j.bcp.2009.09.021
DOI: 10.1016/j.bcp.2009.09.021
Stimulation of human T cells with sulfonamides and sulfonamide metabolites (Journal article)
Castrejon, J. L., Berry, N., El-Ghaiesh, S., Gerber, B., Pichler, W. J., Park, B. K., & Naisbitt, D. J. (2010). Stimulation of human T cells with sulfonamides and sulfonamide metabolites. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 125(2), 411-418. doi:10.1016/j.jaci.2009.10.031
DOI: 10.1016/j.jaci.2009.10.031
Stimulation of sulfamethoxazole and sulfamethoxazole metabolite specific T-cells in patients with cystic fibrosis (Conference Paper)
Elsheikh, A., Callan, H., Monshi, M., Lavergne, S., Castrejon, J., El-Ghaiesh, S., . . . Naisbitt, D. J. (2010). Stimulation of sulfamethoxazole and sulfamethoxazole metabolite specific T-cells in patients with cystic fibrosis. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 297). Retrieved from http://gateway.webofknowledge.com/
Amewu, R., Gibbons, P., Mukhtar, A., Stachulski, A. V., Ward, S. A., Hall, C., . . . O'Neill, P. M. (2010). Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols. ORGANIC & BIOMOLECULAR CHEMISTRY, 8(9), 2068-2077. doi:10.1039/b924319d
T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays (Journal article)
Martin, S. F., Esser, P. R., Schmucker, S., Dietz, L., Naisbitt, D. J., Park, B. K., . . . Sallusto, F. (2010). T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays. CELLULAR AND MOLECULAR LIFE SCIENCES, 67(24), 4171-4184. doi:10.1007/s00018-010-0495-3
DOI: 10.1007/s00018-010-0495-3
TeloVac trial translational studies: investigation of the immune response to GV1001 (Conference Paper)
Shaw, V., Naisbitt, D., Costello, E., Farrell, J., Park, B. K., Neoptolemos, J., & Middleton, G. (2010). TeloVac trial translational studies: investigation of the immune response to GV1001. In IMMUNOLOGY Vol. 131 (pp. 164). Retrieved from http://gateway.webofknowledge.com/
The accumulation and metabolism of zidovudine in 3T3-F442A pre-adipocytes (Journal article)
Janneh, O., Owen, A., Bray, P. G., Back, D. J., & Pirmohamed, M. (2010). The accumulation and metabolism of zidovudine in 3T3-F442A pre-adipocytes. BRITISH JOURNAL OF PHARMACOLOGY, 159(2), 484-493. doi:10.1111/j.1476-5381.2009.00552.x
DOI: 10.1111/j.1476-5381.2009.00552.x
The chemical and molecular basis of mammalian cell susceptibility to cell death induced by the artemisinin antimalarials (Conference Paper)
Mercer, A. E., Copple, I. M., Maggs, J. L., & Park, B. K. (2010). The chemical and molecular basis of mammalian cell susceptibility to cell death induced by the artemisinin antimalarials. In TOXICOLOGY Vol. 278 (pp. 358-359). doi:10.1016/j.tox.2010.08.110
DOI: 10.1016/j.tox.2010.08.110
Fleeman, N., McLeod, C., Bagust, A., Beale, S., Boland, A., Dundar, Y., . . . Dickson, R. (2010). The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation. HEALTH TECHNOLOGY ASSESSMENT, 14(3), 1-+. doi:10.3310/hta14030
The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity (Journal article)
Copple, I. M., Goldring, C. E., Kitteringham, N. R., & Park, B. K. (2010). The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.. Handbook of experimental pharmacology, (196), 233-266. doi:10.1007/978-3-642-00663-0_9
DOI: 10.1007/978-3-642-00663-0_9
The potential of cytokines as safety biomarkers for drug-induced liver injury (Journal article)
Laverty, H. G., Antoine, D. J., Benson, C., Chaponda, M., Williams, D., & Park, B. K. (2010). The potential of cytokines as safety biomarkers for drug-induced liver injury. European Journal of Clinical Pharmacology, 66(10), 961-976. doi:10.1007/s00228-010-0862-x
DOI: 10.1007/s00228-010-0862-x
The transcription factor Nrf2 regulates multiple functions in dendritic cells - implications for CD8 T-cell activation and tolerance (Conference Paper)
Yeang, H. X. A., Hamdam, J., Abbas, L., Goodwin, C., Walsh, J., Kitteringham, N. R., . . . Sathish, J. G. (2010). THE TRANSCRIPTION FACTOR NRF2 REGULATES MULTIPLE FUNCTIONS IN DENDRITIC CELLS - IMPLICATIONS FOR CD8 T CELL ACTIVATION AND TOLERANCE. In British Society for Immunology (pp. 50). Liverpool: BSI
The Transcription Factor Nrf2 Affects Dendritic Cell Maturation and Phagocytic Function (Conference Paper)
Yeang, H. X. A., Hamdam, J., Abbas, L., Goodwin, C., Walsh, J., Kitteringham, N. R., . . . Sathish, J. G. (2010). The Transcription Factor Nrf2 Affects Dendritic Cell Maturation and Phagocytic Function. In British Society for Immunology (pp. 51). Liverpool: BSI.
Toxicological Consequences of Drug-Drug Interactions (Chapter)
Walsh, R. J., Srivastava, A., Antoine, D. J., Williams, D. P., & Park, B. K. (2010). Toxicological Consequences of Drug-Drug Interactions. In S. K. Pang, D. A. Rodrigues, & R. M. Peter (Eds.), and Transporter Based Drug-Drug Interactions: Progress and Future Challenges (pp. 651-664). New York, London: Springer
Use of the parameterised finite element method to robustly and efficiently evolve the edge of a moving cell (Journal article)
Neilson, M. P., Mackenzie, J. A., Webb, S. D., & Insall, R. H. (2010). Use of the parameterised finite element method to robustly and efficiently evolve the edge of a moving cell. Integrative Biology, 2(11-12), 687. doi:10.1039/c0ib00047g
VEGF Stimulates RCAN1.4 Expression in Endothelial Cells via a Pathway Requiring Ca2+/Calcineurin and Protein Kinase C-δ (Journal article)
Holmes, K., Chapman, E., See, V., & Cross, M. J. (2010). VEGF Stimulates RCAN1.4 Expression in Endothelial Cells via a Pathway Requiring Ca2+/Calcineurin and Protein Kinase C-δ. PLoS ONE, 5(7), e11435. doi:10.1371/journal.pone.0011435
DOI: 10.1371/journal.pone.0011435
VKORC1 and warfarin resistance (Conference Paper)
Zhang, J. E., Alfirevic, A., Carr, D., Spencer, K., Mountford, R., & Pirmohamed, M. (2010). VKORC1 and warfarin resistance. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 297). Retrieved from http://gateway.webofknowledge.com/
Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups (Journal article)
Limdi, N. A., Wadelius, M., Cavallari, L., Eriksson, N., Crawford, D. C., Lee, M. -T. M., . . . Cons, I. W. P. (2010). Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups. BLOOD, 115(18), 3827-3834. doi:10.1182/blood-2009-12-255992
DOI: 10.1182/blood-2009-12-255992