2012
372 Autophagy is Required for the Degradation of Phospholamban in Mouse Neonatal Cardiomyocytes (Journal article)
Teng, A., Miyake, T., Sharma, P., Zhang, L., Liu, P., & Gramolini, A. (2012). 372 Autophagy is Required for the Degradation of Phospholamban in Mouse Neonatal Cardiomyocytes. Canadian Journal of Cardiology, 28(5), S237. doi:10.1016/j.cjca.2012.07.350
DOI: 10.1016/j.cjca.2012.07.350
5th Anniversary meeting of the European Research Network Pharmacogenetics/Pharmacogenomics. 8-9 December 2011, Utrecht, The Netherlands (Journal article)
Fox, J. C., Daly, A., Cascorbi, I., Alfirevic, A., Linden, H., & Maitland-van der Zee, A. H. (2012). 5th Anniversary meeting of the European Research Network Pharmacogenetics/Pharmacogenomics. 8-9 December 2011, Utrecht, The Netherlands. Pharmacogenomics, 13(7), 747-749.
Adverse Drug Reactions Causing Admission to a Paediatric Hospital (Journal article)
Gallagher, R. M., Mason, J. R., Bird, K. A., Kirkham, J. J., Peak, M., Williamson, P. R., . . . Smyth, R. L. (2012). Adverse Drug Reactions Causing Admission to a Paediatric Hospital. PLOS ONE, 7(12). doi:10.1371/journal.pone.0050127
DOI: 10.1371/journal.pone.0050127
An evaluation of gene-gene interaction between the CYP2C9 and VKORC1 genotypes affecting the anticoagulant effect of phenprocoumon and acenocoumarol (Journal article)
Van Schie, R. M. F., Babajeff, A. M. V., Schalekamp, T., Wessels, J. A. M., Le Cessie, S., De Boer, A., . . . Grp, E. U. -P. A. C. T. S. (2012). An evaluation of gene-gene interaction between the CYP2C9 and VKORC1 genotypes affecting the anticoagulant effect of phenprocoumon and acenocoumarol. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 10(5), 767-772. doi:10.1111/j.1538-7836.2012.04694.x
DOI: 10.1111/j.1538-7836.2012.04694.x
Analysis of the rat primary hepatocyte nuclear proteome through sub-cellular fractionation (Journal article)
Rowe, C., Jenkins, R. E., Kitteringham, N. R., Park, K. B., & Goldring, C. (2012). Analysis of the rat primary hepatocyte nuclear proteome through sub-cellular fractionation. Journal of Integrated OMICS, 2(2). doi:10.5584/jiomics.v2i2.102
Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics (Journal article)
Abdullah, A., Kitteringham, N. R., Jenkins, R. E., Goldring, C., Higgins, L., Yamamoto, M., . . . Park, B. K. (2012). Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics.. Pharmacological reports : PR, 64(3), 680-697. doi:10.1016/s1734-1140(12)70863-0
DOI: 10.1016/s1734-1140(12)70863-0
Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS (Journal article)
Liptrott, N. J., Pushpakom, S., Wyen, C., Fätkenheuer, G., Hoffmann, C., Mauss, S., . . . Owen, A. (2012). Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS. Pharmacogenetics and Genomics, 22(1), 10-19. doi:10.1097/FPC.0b013e32834dd82e
DOI: 10.1097/FPC.0b013e32834dd82e
Autophagy is required for the degradation of phospholamban in mouse neonatal cardiomyocytes (Conference Paper)
Teng, A. C., Miyake, T., Sharma, P., Zhang, L., Liu, P., & Gramolini, A. O. (2012). AUTOPHAGY IS REQUIRED FOR THE DEGRADATION OF PHOSPHOLAMBAN IN MOUSE NEONATAL CARDIOMYOCYTES. In CANADIAN JOURNAL OF CARDIOLOGY Vol. 28 (pp. S237). doi:10.1016/j.cjca.2012.07.350
DOI: 10.1016/j.cjca.2012.07.350
Biological Significance of Local TGF-β Activation in Liver Diseases (Journal article)
Hayashi, H., & Sakai, T. (2012). Biological Significance of Local TGF-β Activation in Liver Diseases. Frontiers in Physiology, 3. doi:10.3389/fphys.2012.00012
Cell-Surface Proteomics Identifies Lineage-Specific Markers of Embryo-Derived Stem Cells (Journal article)
Rugg-Gunn, P. J., Cox, B. J., Lanner, F., Sharma, P., Ignatchenko, V., McDonald, A. C. H., . . . Kislinger, T. (2012). Cell-Surface Proteomics Identifies Lineage-Specific Markers of Embryo-Derived Stem Cells. DEVELOPMENTAL CELL, 22(4), 887-901. doi:10.1016/j.devcel.2012.01.005
DOI: 10.1016/j.devcel.2012.01.005
Characterisation of antidrug antibodies (ADA) against therapeutic interferon beta (Conference Paper)
Govindappa, K., Sethu, S., Wadwa, M., Stebbings, R., Kimber, I., Naisbitt, D. J., . . . Sathish, J. G. (2012). Characterisation of antidrug antibodies (ADA) against therapeutic interferon beta. In IMMUNOLOGY Vol. 137 (pp. 655-656). Retrieved from http://gateway.webofknowledge.com/
Characterization of B-cell resposnes in piperacillin allergic and tolerant patients (Journal article)
Sullivan, A., Amali, M., Faulkner, L., Whitaker, P., Peckham, D., Pirmohamed, M., . . . Naisbitt, D. J. (2012). Characterization of B-cell resposnes in piperacillin allergic and tolerant patients. Allergy.
Characterization of drug presentation to T-lymphocytes using clones isolated from piperacillin hypersensitive human patients. (Journal article)
El-Ghaiesh, S., Monshi, M., Whitaker, P., Meng, X., Jenkins, R., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of drug presentation to T-lymphocytes using clones isolated from piperacillin hypersensitive human patients.. J Pharmacol Exp Ther, 341, 597-610.
Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis (Journal article)
El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900
Chronic inflammatory pain is associated with increased excitability and hyperpolarization-activated current (Ih) in C- but not Aδ-nociceptors (Journal article)
Weng, X., Smith, T., Sathish, J., & Djouhri, L. (2012). Chronic inflammatory pain is associated with increased excitability and hyperpolarization-activated current (Ih) in C- but not Aδ-nociceptors. Pain, 153(4), 900-914. doi:10.1016/j.pain.2012.01.019
DOI: 10.1016/j.pain.2012.01.019
Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing (Journal article)
Martin, M. A., Klein, T. E., Dong, B. J., Pirmohamed, M., Haas, D. W., & Kroetz, D. L. (2012). Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing. CLINICAL PHARMACOLOGY & THERAPEUTICS, 91(4), 734-738. doi:10.1038/clpt.2011.355
Clinical picture of drug hypersensitivity reactions (Journal article)
Bell, C., Naisbitt, D. J., & Park, B. K. (2012). Clinical picture of drug hypersensitivity reactions. ALTA.
Clinical Proteomics Getting to the Heart of the Matter (Journal article)
Chugh, S., Sharma, P., Kislinger, T., & Gramolini, A. O. (2012). Clinical Proteomics Getting to the Heart of the Matter. CIRCULATION-CARDIOVASCULAR GENETICS, 5(3), O1-O9. doi:10.1161/CIRCGENETICS.110.957761
DOI: 10.1161/CIRCGENETICS.110.957761
Commentary: changing aetiology of peptic ulcers - author's reply (Journal article)
Musumba, C., Pritchard, D. M., & Pirmohamed, M. (2012). Commentary: changing aetiology of peptic ulcers - author's reply. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 36(3), 292-293. doi:10.1111/j.1365-2036.2012.05176.x
DOI: 10.1111/j.1365-2036.2012.05176.x
Cost-effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs (Journal article)
Verhoef, T. I., Redekop, W. K., van Schie, R. M. F., Bayat, S., Daly, A. K., Geitona, M., . . . Grp, E. U. -P. A. C. T. (2012). Cost-effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs. PHARMACOGENOMICS, 13(12), 1405-1417. doi:10.2217/PGS.12.124
Development of in vitro assays to characterize primary T cell responses to drugs (Journal article)
Faulkner, J., Martinsson, K., Castelazo, A. S., Cederbrant, K., Schuppe-Koistinen, I., Powell, H., . . . Park, B. K. (2012). Development of in vitro assays to characterize primary T cell responses to drugs. Toxicological Sciences, 127, 150-158.
Drug Bioactivation and Oxidative Stress. (Chapter)
Webb, H. M., Regan, S., Antoine, D. J., Lane, N., Walsh, R. J., Srivastava, A., . . . Park, B. K. (2012). Drug Bioactivation and Oxidative Stress.. In A. Lyubimov (Ed.), Encyclopaedia of Drug Metabolism and Interactions. (pp. 1-44). International: John Wiley and Sons.
Enhancing Communication about Paediatric Medicines: Lessons from a Qualitative Study of Parents' Experiences of Their Child's Suspected Adverse Drug Reaction (Journal article)
Arnott, J., Hesselgreaves, H., Nunn, A. J., Peak, M., Pirmohamed, M., Smyth, R. L., . . . Young, B. (2012). Enhancing Communication about Paediatric Medicines: Lessons from a Qualitative Study of Parents' Experiences of Their Child's Suspected Adverse Drug Reaction. PLOS ONE, 7(10). doi:10.1371/journal.pone.0046022
DOI: 10.1371/journal.pone.0046022
ERK5: Structure, regulation and function (Journal article)
Nithianandarajah-Jones, G. N., Wilm, B., Goldring, C. E. P., Mueller, J., & Cross, M. J. (2012). ERK5: Structure, regulation and function. CELLULAR SIGNALLING, 24(11), 2187-2196. doi:10.1016/j.cellsig.2012.07.007
DOI: 10.1016/j.cellsig.2012.07.007
Evidence for Metabolic Cleavage of a PEGylated Protein in Vivo Using Multiple Analytical Methodologies (Journal article)
Elliott, V. L., Edge, G. T., Phelan, M. M., Lian, L. -Y., Webster, R., Finn, R. F., . . . Kitteringham, N. R. (2012). Evidence for Metabolic Cleavage of a PEGylated Protein in Vivo Using Multiple Analytical Methodologies. Molecular Pharmaceutics, 9(5), 1291-1301. doi:10.1021/mp200587m
Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials (Journal article)
Copple, I. M., Mercer, A. E., Firman, J., Donegan, G., Herpers, B., Wong, M. H. L., . . . Park, B. K. (2012). Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials. MOLECULAR MEDICINE, 18(7), 1045-1055. doi:10.2119/molmed.2012.00154
DOI: 10.2119/molmed.2012.00154
Explanation for HLA-B*57:01-linked immune-mediated abacavir-induced hypersensitivity (Journal article)
Alfirevic, A., Park, B. K., Pirmohamed, M., & Naisbitt, D. J. (2012). Explanation for HLA-B*57:01-linked immune-mediated abacavir-induced hypersensitivity. PHARMACOGENOMICS, 13(14), 1567-1569. doi:10.2217/PGS.12.146
Fibronectin is essential for survival but is dispensable for proliferation of hepatocytes in acute liver injury in mice. (Journal article)
Moriya, K., Sakai, K., Yan, M. H., & Sakai, T. (2012). Fibronectin is essential for survival but is dispensable for proliferation of hepatocytes in acute liver injury in mice.. Hepatology (Baltimore, Md.), 56(1), 311-321.
General pharmacology (Chapter)
Schachter, M., & Pirmohamed, M. (2012). General pharmacology. In Clinical Pharmacology: Eleventh Edition (pp. 74-109). doi:10.1016/B978-0-7020-4084-9.00047-1
DOI: 10.1016/B978-0-7020-4084-9.00047-1
Genetics and the potential for predictive tests in adverse drug reactions (Journal article)
Pirmohamed, M. (2012). Genetics and the potential for predictive tests in adverse drug reactions.. Chemical immunology and allergy, 97, 18-31. doi:10.1159/000335613
HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review (Journal article)
Yip, V. L., Marson, A. G., Jorgensen, A. L., Pirmohamed, M., & Alfirevic, A. (2012). HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review. CLINICAL PHARMACOLOGY & THERAPEUTICS, 92(6), 757-765. doi:10.1038/clpt.2012.189
HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review. (Journal article)
Yip, V., Marson, T., Jorgensen, A., Pirmohamed, M., & Alfirevic, A. (2012). HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review.. Clinical Pharmacology and Therapeutics, 92(6), 757-765.
HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury (Journal article)
Monshi, M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2012). HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology.
Haloarene Derivatives of Carbamazepine with Reduced Bioactivation Liabilities: 2-Monohalo and 2,8-Dihalo Derivatives (Journal article)
Elliott, E. -C., Regan, S. L., Maggs, J. L., Bowkett, E. R., Parry, L. J., Williams, D. P., . . . Stachulski, A. V. (2012). Haloarene Derivatives of Carbamazepine with Reduced Bioactivation Liabilities: 2-Monohalo and 2,8-Dihalo Derivatives. Journal of Medicinal Chemistry, 55(22), 9773-9784. doi:10.1021/jm301013n
Human pluripotent stem cells for modeling toxicity (Journal article)
Sison-Young, R. L., Kia, R., Heslop, J., Kelly, L., Rowe, C., Cross, M. J., . . . Goldring, C. E. (2012). Human pluripotent stem cells for modeling toxicity. Adv Pharmacol, 63, 207-256. doi:10.1016/B978-0-12-398339-8.00006-9
DOI: 10.1016/B978-0-12-398339-8.00006-9
IL-8 Release from Human Neutrophils Cultured with Pro-Haptenic Chemical Sensitizers (Journal article)
Kiorpelidou, E., Foster, B., Farrell, J., Ogese, M. O., Faulkner, L., Goldring, C. E., . . . Naisbitt, D. J. (2012). IL-8 Release from Human Neutrophils Cultured with Pro-Haptenic Chemical Sensitizers. CHEMICAL RESEARCH IN TOXICOLOGY, 25(10), 2054-2056. doi:10.1021/tx300350s
IL-8 secretion from primary neutrophils cultured with haptenic and pro-haptenic chemical sensitizers (Journal article)
Kiorpelidou, E., Foster, B., Naisbitt, D. J., & Park, B. K. (2012). IL-8 secretion from primary neutrophils cultured with haptenic and pro-haptenic chemical sensitizers. Che Res Toxicol.
Immunogenicity to Biologics: Mechanisms, Prediction and Reduction (Journal article)
Sethu, S., Govindappa, K., Alhaidari, M., Pirmohamed, M., Park, K., & Sathish, J. (2012). Immunogenicity to Biologics: Mechanisms, Prediction and Reduction. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 60(5), 331-344. doi:10.1007/s00005-012-0189-7
DOI: 10.1007/s00005-012-0189-7
Impact of the CYP4F2 p.V433M Polymorphism on Coumarin Dose Requirement: Systematic Review and Meta-Analysis (Journal article)
Danese, E., Montagnana, M., Johnson, J. A., Rettie, A. E., Zambon, C. F., Lubitz, S. A., . . . Fava, C. (2012). Impact of the CYP4F2 p.V433M Polymorphism on Coumarin Dose Requirement: Systematic Review and Meta-Analysis. CLINICAL PHARMACOLOGY & THERAPEUTICS, 92(6), 746-756. doi:10.1038/clpt.2012.184
Impact of the CYP4F2 p.V433M polymorphism on coumarin dose requirement: systematic review and meta-analysis (Journal article)
Danese, E., Montagnana, M., Johnson, J. A., Rettie, A. E., Zambon, C. F., Lubitz, S. A., . . . Fava, C. (2012). Impact of the CYP4F2 p.V433M polymorphism on coumarin dose requirement: systematic review and meta-analysis. Clin Pharmacol Ther, 92(6), 746-756. doi:10.1038/clpt.2012.184
Improved Glycaemia Correlates with Liver Fat Reduction in Obese, Type 2 Diabetes, Patients Given Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists (Journal article)
Cuthbertson, D. J., Irwin, A., Gardner, C. J., Daousi, C., Purewal, T., Furlong, N., . . . Kemp, G. J. (2012). Improved Glycaemia Correlates with Liver Fat Reduction in Obese, Type 2 Diabetes, Patients Given Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists. PLOS ONE, 7(12). doi:10.1371/journal.pone.0050117
DOI: 10.1371/journal.pone.0050117
In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers (Journal article)
Alfirevic, A., Gonzalez-Galarza, F., Bell, C., Martinsson, K., Platt, V., Bretland, G., . . . Pirmohamed, M. (2012). In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers. GENOME MEDICINE, 4. doi:10.1186/gm350
Influence of CYP2C9 and VKORC1 on Patient Response to Warfarin: A Systematic Review and Meta-Analysis (Journal article)
Jorgensen, A. L., FitzGerald, R. J., Oyee, J., Pirmohamed, M., & Williamson, P. R. (2012). Influence of CYP2C9 and VKORC1 on Patient Response to Warfarin: A Systematic Review and Meta-Analysis. PLOS ONE, 7(8). doi:10.1371/journal.pone.0044064
DOI: 10.1371/journal.pone.0044064
Letter: are idiopathic (non-NSAID, non-Helicobacter pylori) ulcers really increasing? Authors' reply (Journal article)
Musumba, C., Hopkins, M., Pritchard, D. M., & Pirmohamed, M. (2012). Letter: are idiopathic (non-NSAID, non-Helicobacter pylori) ulcers really increasing? Authors' reply. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 36(6), 601-602. doi:10.1111/apt.12001
Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs (Journal article)
Urban, T. J., Shen, Y., Stolz, A., Chalasani, N., Fontana, R. J., Rochon, J., . . . Consort, I. S. A. E. (2012). Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs. PHARMACOGENETICS AND GENOMICS, 22(11), 784-795. doi:10.1097/FPC.0b013e3283589a76
DOI: 10.1097/FPC.0b013e3283589a76
Long-term anticoagulant effects of CYP2C9 and VKORC1 genotypes in phenprocoumon users (Journal article)
Verhoef, T. I., Redekop, W. K., Hegazy, H., de Boer, A., Maitland-van der Zee, A. H., & Grp, E. U. -P. A. C. T. (2012). Long-term anticoagulant effects of CYP2C9 and VKORC1 genotypes in phenprocoumon users. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 10(12), 2610-2612. doi:10.1111/jth.12007
Long-term anticoagulant effects of the CYP2C9 and VKORC1 genotypes in acenocoumarol users (Journal article)
Verhoef, T. I., Redekop, W. K., Buikema, M. M., Schalekamp, T., van der Meer, F. J. M., Le Cessie, S., . . . Grp, E. U. -P. A. C. T. (2012). Long-term anticoagulant effects of the CYP2C9 and VKORC1 genotypes in acenocoumarol users. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 10(4), 606-614. doi:10.1111/j.1538-7836.2012.04633.x
DOI: 10.1111/j.1538-7836.2012.04633.x
Yeang, H. X. A., Hamdam, J. M., Al-Huseini, L. M. A., Sethu, S., Djouhri, L., Walsh, J., . . . Sathish, J. G. (2012). Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signaling in Dendritic Cells. Journal of Biological Chemistry, 287(13), 10556-10564. doi:10.1074/jbc.M111.322420
Mechanism-Based Urinary Biomarkers to Identify the Potential for Aminoglycoside-Induced Nephrotoxicity in Premature Neonates: A Proof-of-Concept Study (Journal article)
McWilliam, S. J., Antoine, D. J., Sabbisetti, V., Turner, M. A., Farragher, T., Bonventre, J. V., . . . Pirmohamed, M. (2012). Mechanism-Based Urinary Biomarkers to Identify the Potential for Aminoglycoside-Induced Nephrotoxicity in Premature Neonates: A Proof-of-Concept Study. PLOS ONE, 7(8). doi:10.1371/journal.pone.0043809
DOI: 10.1371/journal.pone.0043809
Microwave ablation of ex vivo human liver and colorectal liver metastases with a novel 14.5 GHz generator (Journal article)
Jones, R. P., Kitteringham, N. R., Fenwick, S. W., Poston, G. J., Malik, H. Z., Terlizzo, M., & Ghaneh, P. (2012). Microwave ablation of ex vivo human liver and colorectal liver metastases with a novel 14.5 GHz generator. International Journal of Hyperthermia, 28(1), 43-54.
Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity (Journal article)
Antoine, D. J., Jenkins, R. E., Dear, J. W., Williams, D. P., McGill, M. R., McGill, M. R., . . . Park, B. K. (2012). Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity.. Journal of hepatology, 56(5), 1070-1079. doi:10.1016/j.jhep.2011.12.019
DOI: 10.1016/j.jhep.2011.12.019
Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells (Journal article)
Daubner, B., Groux-Keller, M., Hausmann, O. V., Kawabata, T., Naisbitt, D. J., Park, B. K., . . . Pichler, W. J. (2012). Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells. ALLERGY, 67(1), 58-66. doi:10.1111/j.1398-9995.2011.02720.x
DOI: 10.1111/j.1398-9995.2011.02720.x
Nonimmediate beta-lactam reactions in patients with cystic fibrosis (Journal article)
Whitaker, P., Naisbitt, D., & Peckham, D. (2012). Nonimmediate beta-lactam reactions in patients with cystic fibrosis. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 12(4), 369-375. doi:10.1097/ACI.0b013e328355b849
DOI: 10.1097/ACI.0b013e328355b849
Off-label and unlicensed medicine use and adverse drug reactions in children: a narrative review of the literature (Journal article)
Mason, J., Pirmohamed, M., & Nunn, T. (2012). Off-label and unlicensed medicine use and adverse drug reactions in children: a narrative review of the literature. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 68(1), 21-28. doi:10.1007/s00228-011-1097-1
DOI: 10.1007/s00228-011-1097-1
Paediatric use of mycophenolate mofetil (Journal article)
Downing, H. J., Pirmohamed, M., Beresford, M. W., & Smyth, R. L. (2013). Paediatric use of mycophenolate mofetil. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 75(1), 45-59. doi:10.1111/j.1365-2125.2012.04305.x
DOI: 10.1111/j.1365-2125.2012.04305.x
Perspectives to predict idiosyncratic drug-induced liver injury in vitro. (Journal article)
Gibson, A., Eakins, R., Goldring, C. E. P., Naisbitt, D. J., Rowe, C., & Park, B. K. (2012). Perspectives to predict idiosyncratic drug-induced liver injury in vitro.. Drug Metabolism Reviews.
Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy (Journal article)
Horne, B. D., Lenzini, P. A., Wadelius, M., Jorgensen, A. L., Kimmel, S. E., Ridker, P. M., . . . Gage, B. F. (2012). Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy. THROMBOSIS AND HAEMOSTASIS, 107(2), 232-240. doi:10.1160/TH11-06-0388
Pharmacogenetics for the prescriber (Journal article)
Pirmohamed, M. (2012). Pharmacogenetics for the prescriber. Medicine, 40(7), 362-365. doi:10.1016/j.mpmed.2012.04.005
DOI: 10.1016/j.mpmed.2012.04.005
Pharmacogenetics of Adverse Drug Reactions (Chapter)
Daly, A. K., Armstrong, M., & Pirmohamed, M. (2012). Pharmacogenetics of Adverse Drug Reactions. In Pharmacogenetics and Individualized Therapy (pp. 295-321). doi:10.1002/9781118116494.ch10
DOI: 10.1002/9781118116494.ch10
Pharmacogenetics of Adverse Drug Reactions (Chapter)
Pushpakom, S. P., & Pirmohamed, M. (2012). Pharmacogenetics of Adverse Drug Reactions. In Stephens' Detection and Evaluation of Adverse Drug Reactions: Principles and Practice, Sixth Edition (pp. 121-156). doi:10.1002/9780470975053.ch2
DOI: 10.1002/9780470975053.ch2
Pragmatic randomised trials using routine electronic health records: putting them to the test (Journal article)
van Staa, T. -P., Goldacre, B., Gulliford, M., Cassell, J., Pirmohamed, M., Taweel, A., . . . Smeeth, L. (2012). Pragmatic randomised trials using routine electronic health records: putting them to the test. BRITISH MEDICAL JOURNAL, 344. doi:10.1136/bmj.e55
Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility (Journal article)
Alfirevic, A., & Pirmohamed, M. (2012). Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility. CLINICAL PHARMACOLOGY & THERAPEUTICS, 92(3), 376-380. doi:10.1038/clpt.2012.107
Regulation of histone deacetylases by Nrf2 in immune cells (Journal article)
Al-Huseini, L. M., Hamdam, J. M., Sethu, S., Kitteringham, N., Park1, B. K., Goldring, C. E., & Sathish, J. G. (2012). Regulation of histone deacetylases by Nrf2 in immune cells
Relative contribution of IgG subclasses to immunogenicity of therapeutic interferon beta (Journal article)
Sethu, S., Govindappa, K., Pirmohamed, M., Park, K. B., & Sathish, J. G. (2012). Relative contribution of IgG subclasses to immunogenicity of therapeutic interferon beta
Release of intracellular calcium primes chronic myeloid leukaemia cells for tyrosine kinase inhibitor-induced apoptosis (Journal article)
Forchap, S. L., Pirmohamed, M., & Clark, R. E. (2012). Release of intracellular calcium primes chronic myeloid leukaemia cells for tyrosine kinase inhibitor-induced apoptosis. LEUKEMIA, 26(3), 490-498. doi:10.1038/leu.2011.231
Reported paediatric adverse drug reactions in the UK 2000-2009 (Journal article)
Hawcutt, D. B., Mainie, P., Riordan, A., Smyth, R. L., & Pirmohamed, M. (2012). Reported paediatric adverse drug reactions in the UK 2000-2009. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 73(3), 437-446. doi:10.1111/j.1365-2125.2011.04113.x
DOI: 10.1111/j.1365-2125.2011.04113.x
Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal (Journal article)
Alfirevic, A., McCormack, M., Pirmohamed, M., & Cavalleri, G. L. (2012). Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal. BRITISH JOURNAL OF DERMATOLOGY, 166(1), 12-14. doi:10.1111/j.1365-2133.2011.10760.x
DOI: 10.1111/j.1365-2133.2011.10760.x
Serum microRNA Biomarkers for Drug-Induced Liver Injury (Journal article)
Starkey Lewis, P. J., Merz, M., Couttet, P., Grenet, O., Dear, J., Antoine, D. J., . . . Moggs, J. G. (2012). Serum microRNA Biomarkers for Drug-Induced Liver Injury. Clinical Pharmacology & Therapeutics, 92(3), 291-293. doi:10.1038/clpt.2012.101
Signalling properties of the TGN1412 biosimilar NIB1412 (Journal article)
Thaventhiran, T., Sethu, S., Park, B. K., Stebbings, R., & Sathish, J. G. (2012). Signalling properties of the TGN1412 biosimilar NIB1412.
Structural determination of the phosphorylation domain of the ryanodine receptor (Journal article)
Sharma, P., Ishiyama, N., Nair, U., Li, W., Dong, A., Miyake, T., . . . Gramolini, A. O. (2012). Structural determination of the phosphorylation domain of the ryanodine receptor. FEBS JOURNAL, 279(20), 3952-3964. doi:10.1111/j.1742-4658.2012.08755.x
DOI: 10.1111/j.1742-4658.2012.08755.x
T-cell responses to drugs and drug metabolites (Chapter)
Earnshaw, C., Park, B. K., & Naisbitt, D. J. (2012). T-cell responses to drugs and drug metabolites. In S. F. Martin (Ed.), T Lymphocytes as Tools in Chemical and Drug Allergy (pp. 180-193). San Fransisco: Springer.
T-cell responses to flucloxacillin protein adducts in a mouse model of immunogenicity (Journal article)
Nattrass, R., Jenkins, R., Faulkner, L., Yaseen, F., Park, B. K., & Naisbitt, D. J. (2012). T-cell responses to flucloxacillin protein adducts in a mouse model of immunogenicity. Tox Sci.
T-cell responses to halogenated carbamazepine (Journal article)
Farrell, J., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2012). T-cell responses to halogenated carbamazepine. Chem Res Toxicol.
The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs (Journal article)
Faulkner, L., Martinsson, K., Santoyo-Castelazo, A., Cederbrant, K., Schuppe-Koistinen, I., Powell, H., . . . Park, B. K. (2012). The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs. TOXICOLOGICAL SCIENCES, 127(1), 150-158. doi:10.1093/toxsci/kfs080
The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers (Journal article)
Harrill, A. H., Roach, J., Fier, I., Eaddy, J. S., Kurtz, C. L., Antoine, D. J., . . . Watkins, P. B. (2012). The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers. Clinical Pharmacology & Therapeutics, 92(2), 214-220. doi:10.1038/clpt.2012.40
The extent of degeneration of cruciate ligament is associated with chondrogenic differentiation in patients with osteoarthritis of the knee. (Journal article)
Kumagai, K., Sakai, K., Kusayama, Y., Akamatsu, Y., Sakamaki, K., Morita, S., . . . Sakai, T. (2012). The extent of degeneration of cruciate ligament is associated with chondrogenic differentiation in patients with osteoarthritis of the knee.. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, 20(11), 1258-1267.
The generation, detection and effects of reactive drug metabolites. Med Res Reviews. (Journal article)
Baillie, T. A., Park, B. K., Obach, R. S., Dalvie, D. K., Williams, D. P., Srivastava, A., . . . Stachulski, A. V. (2012). The generation, detection and effects of reactive drug metabolites. Med Res Reviews.. Med Res Reviews.
The Keap1-Nrf2 cell defense pathway--a promising therapeutic target? (Journal article)
Copple, I. M. (2012). The Keap1-Nrf2 cell defense pathway--a promising therapeutic target?. Advances in pharmacology (San Diego, Calif.), 63, 43-79. doi:10.1016/b978-0-12-398339-8.00002-1
DOI: 10.1016/b978-0-12-398339-8.00002-1
Musumba, C., Jorgensen, A., Sutton, L., Van Eker, D., Moorcroft, J., Hopkins, M., . . . Pirmohamed, M. (2012). The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 36(1), 48-56. doi:10.1111/j.1365-2036.2012.05118.x
DOI: 10.1111/j.1365-2036.2012.05118.x
The use of anti-programmed death ligand antibodies to enhance in vitro antigen-specific T-cell priming (Journal article)
Gibson, A., Faulkner, L., Park, B. K., & Naisbitt, D. J. (2012). The use of anti-programmed death ligand antibodies to enhance in vitro antigen-specific T-cell priming. Tox Sci.
Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy through transforming growth factor-beta1 activation in mice (Journal article)
Hayashi, H., Sakai, K., Baba, H., & Sakai, T. (2012). Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy through transforming growth factor-beta1 activation in mice. Hepatology, 55(5), 1562-1573. doi:10.1002/hep.24800
Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation (Journal article)
Xue, M., Rabbani, N., Momiji, H., Imbasi, P., Anwar, M., Kitteringham, N., . . . Thornalley, P. (2012). Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation. Biochemical Journal, 443(1), 213-222. doi:10.1042/BJ20111648
Validation of the isolation and quantification of kidney enriched miRNAs for use as biomarkers (Journal article)
Sharkey, J. W., Antoine, D. J., & Park, B. K. (2012). Validation of the isolation and quantification of kidney enriched miRNAs for use as biomarkers. Biomarkers, 17(3), 231-239. doi:10.3109/1354750X.2012.657246
DOI: 10.3109/1354750X.2012.657246
What can we learn from parents about enhancing participation in pharmacovigilance? (Journal article)
Arnott, J., Hesselgreaves, H., Nunn, A. J., Peak, M., Pirmohamed, M., Smyth, R. L., . . . Young, B. (2013). What can we learn from parents about enhancing participation in pharmacovigilance?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 75(4), 1109-1117. doi:10.1111/j.1365-2125.2012.04441.x
DOI: 10.1111/j.1365-2125.2012.04441.x
α-Crystallin B prevents apoptosis after H2O2 exposure in mouse neonatal cardiomyocytes (Journal article)
Chis, R., Sharma, P., Bousette, N., Miyake, T., Wilson, A., Backx, P. H., & Gramolini, A. O. (2012). α-Crystallin B prevents apoptosis after H2O2 exposure in mouse neonatal cardiomyocytes.. American journal of physiology. Heart and circulatory physiology, 303(8), H967-H978. doi:10.1152/ajpheart.00040.2012
DOI: 10.1152/ajpheart.00040.2012