Photo of Professor Samar Hasnain

Professor Samar Hasnain BSc (Honours) MSc PhD

Max Perutz Professor of Molecular Biophysics Biochemistry & Systems Biology

Research

Structure-function studies of metalloproteins and regulatory systems

Structure-function-misfunction of metalloproteins and metal regulatory systems. We utilise X-ray techniques (Protein Crystallography, X-ray Scattering and XAFS), Cryo Electron Microscopy (cryoEM) together with other biophysical techniques.

See: https://www.liverpool.ac.uk/integrative-biology/research/research-groups/molecular-biophysics/research/

Research Group Membership

Research Grants

Japan Partnering : Damage free structures of enzymes of denitrification pathway and their complexes using SF-ROX and SFX at SACLA XFEL

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

July 2019 - July 2023

Why does Nature use modular enzyme architectures for biological catalysis

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

January 2017 - July 2020

Damage Free structures of quinol dependent nitric oxide reductase (qNOR) in complex with nitrite reductase (NiR) from A. xylosoxidans

SCIENCE AND TECHNOLOGY FACILITIES COUNCIL (STFC)

September 2015 - September 2019

A new generation of Crystallographic detector for Multi-user Barkla X-ray laboratory

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

July 2017 - July 2018

Structure-function studies of faulty proteins and their complexes involved in motor neuron disease

MOTOR NEURONE DISEASE ASSOCIATION

October 2015 - September 2018

The cause and effect of SOD1 destabilization on motor neuron disease

MEDICAL RESEARCH FOUNDATION (UK)

October 2015 - April 2019

Transient and Stable Macromolecular complexes formed by Denitrifying Enzymes

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

June 2014 - June 2019

Support of SESAME Networking Activities

DEPARTMENT FOR BUSINESS, ENERGY AND INDUSTRIAL STRATEGY (BEIS) (UK), DEPARTMENT FOR BUSINESS, INNOVATION AND SKILLS (UK)

April 2014 - March 2021

CIC BioGUNE studentships

CIC BIOGUNE (SPAIN)

October 2013 - September 2017

Towards a complete structure-function description of the dentrification pathway

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

April 2008 - October 2009

CIC BiomaGUNE studentships

CIC BIOMAGUNE (SPAIN)

October 2013 - September 2017

From structures to identification of ligand binding pockets to the discovery of therapeutic compounds using fragment based approach for SOD1 MND

MOTOR NEURONE DISEASE ASSOCIATION

January 2010 - December 2012

TDP-43 and the molecular causes of its pathogenicity in neurodegenerative disease

MOTOR NEURONE DISEASE ASSOCIATION

October 2011 - February 2015

Synchrotoran x-ray studies on the stability of dimeric native and FALS mutant structures of CuZn superoxide dismutase: Structure-based lead optimisation with the aim of stabilising the structure.

MOTOR NEURONE DISEASE ASSOCIATION

May 2008 - June 2009

Probing the structure of biological macromolecules in the gas phase with intense x-ray pulses

SCIENCE AND TECHNOLOGY FACILITIES COUNCIL (STFC)

October 2009 - March 2013

New challenges of Structural biology arising from the emergence of brilliant X-ray beams from X-ray Lasers

SCIENCE AND TECHNOLOGY FACILITIES COUNCIL (STFC)

July 2014 - June 2018

Provisionsof MAD/XAFS facililty of the UK structural biology community

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

January 2009 - July 2010

Elucidating mechanisms of proton coupled and conformationally coupled electron transfer in redox enzymes catalysis

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

October 2009 - September 2012

CIC bioGUNE / University of Liverpool PhD programme for 2012/13

CIC BIOGUNE (SPAIN)

October 2012 - December 2016

Structural Protemeomics of Metallo and Membrane Proteins of Pathogens - China Partnering Award

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

April 2008 - March 2010

Structural studies of proteins related to liver disease

CIC BIOGUNE (SPAIN)

September 2011 - August 2015