Medicinal Chemistry with Pharmacology MChem Add to your prospectus

  • Offers study abroad opportunities Offers study abroad opportunities
  • Opportunity to study for a year in China Offers a Year in China
  • This degree is accreditedAccredited

Key information


  • Course length: 4 years
  • UCAS code: F1BF
  • Year of entry: 2018
  • Typical offer: A-level : AAB / IB : 35 / BTEC : Not accepted
chemistry-1

Module details

Programme Year One

Within Chemistry, you will take modules that cover the fundamentals of Inorganic, Organic and Physical Chemistry, plus necessary key skills, totalling 90 credits. Four Chemistry modules combine theoretical and practical aspects and one Chemistry module develops Quantitative and General Key Skills. You will spend between three and six hours per week in the Chemistry laboratory and so will receive a comprehensive training in practical aspects of the subject. Instead of optional modules you will be required to take 30 credits of compulsory modules from Biomedical/Biological Sciences covering Anatomy, Molecular Biology, Pharmacology and Physiology.

Year One Compulsory Modules

  • Introductory Inorganic Chemistry (CHEM111)
    Level1
    Credit level15
    SemesterFirst Semester
    Exam:Coursework weighting50:50
    Aims

    The aim of this module is to give students an understanding of the underlying principles of the chemistry of the main group elements and to give them an appreciation of the importance of this chemistry in everyday life.

    Learning Outcomes

    By the end of this module a student will have an understanding of:

    • The periodic table as an underlying framework for understanding the chemistry of the main group elements
    • The crystal structures of metals and simple ionic solids
    • Lewis acid-Lewis base interactions
    • Systematic chemistry of halides and hydrides of the main group elements
    • Systematic chemistry of halides and hydrides of the main group elements
    • The basic techniques required for the preparation and analysis of simple inorganic compounds

    A student will also have developed the following skills:

    • Planning and time-management associated with practical work
    • Report writing
  • Introductory Organic Chemistry (CHEM130)
    Level1
    Credit level30
    SemesterWhole Session
    Exam:Coursework weighting60:40
    Aims

    The aim of this module is to ensure that students are aware of fundamental principles of organic chemistry, including nomenclature, structure and bonding, and the basic principles of static and dynamic stereochemistry. The major reactions associated with the common functional groups will be covered with emphasis on reaction mechanisms. In addition, this module will provide an introduction to the basic techniques associated with practical synthetic chemistry.

    Learning Outcomes

    By the end of this module students will know:

    • Structures and shapes of major classes of organic compounds
    • Principles of bonding in major classes of organic compounds
    • Basic principles of stereochemistry
    • Important reactions of a range of functional groups
    • An understanding of the major classes of reaction mechanisms
    • The basic techniques of synthetic chemistry (isolation, purification, identification, and design and work-up of reactions) and will have experience of characterisation using spectroscopic techniques and chemical methods.
  • Foundations of Medicinal Chemistry (CHEM141)
    Level1
    Credit level15
    SemesterFirst Semester
    Exam:Coursework weighting80:20
    AimsThe aim of this module is to provide students with and understanding of :1. The key components of cells that act as the building blocks for the key macromolecular structures that are essential in medicinal chemistry.2. How macromolecules interact with each other to allow for natural cellular processes (such as gene expression) that can be exploited by medicinal chemists3. The key drug targets in medicinal chemistry
    Learning Outcomes

    ​Upon successful completion of this module, a student will be able to demonstrate an understanding of the chemical components of cells.

    ​Upon successful completion of this module, a student will be able to demonstrate an understanding of the structure, chemical bonding and interactions of a range of cellular macromolecules that allow natural cellular processes to occur

    ​​Upon successful completion of this module, a student will be able to demonstrate an understanding of the key drug targets in medicinal chemistry, including enzymes, receptors and nucleic acids

  • Introductory Physical Chemistry (CHEM152)
    Level1
    Credit level15
    SemesterSecond Semester
    Exam:Coursework weighting60:40
    Aims

    The main aim of this module is to equip students with an understanding of basic kinetics and thermodynamics as they relate to chemical reactions.

    Learning Outcomes

    By the end of the module students should be familiar with, and be able to make appropriate use of:

    • Basic ideas of energy changes in chemical reactions
    • Ideas relating to the rates of chemical reactions
    • Basic laboratory skills and report writing, including data and error analysis
  • Introductory Spectroscopy (CHEM170)
    Level1
    Credit level15
    SemesterWhole Session
    Exam:Coursework weighting70:30
    Aims

     

    The aim of this module is to introduce modern spectroscopic methods in chemistry. Students will understand
    • the importance of quantum mechanics in understanding atomic structure
    • the interaction of light with matter
    • atomic and molecular spectroscopy
    • information obtained from different spectroscopic techniques
    • the interpretation of spectroscopic data
    • deduction of molecular structure from spectroscopic data

    Learning Outcomes

    By the end of this module, students should have achieved the following learning outcomes:

    • An understanding of atomic structure.
    • The fundamental principles behind rotational, vibrational, electronic spectroscopy, mass spectroscopy, andnuclear magnetic resonance spectroscopy.  
    • Application of spectroscopic techniques to elucidate moecular structure.
    • Be abble to apply this knowledge to real spectroscopic problems.
  • Key Skills for Chemists 1 (CHEM180)
    Level1
    Credit level15
    SemesterWhole Session
    Exam:Coursework weighting0:100
    Aims

    The aim of this module is:

    (i) to equip students with the basic quantitative transferable skills required for the first year of a Chemistry degree programme. (60% of module)

    (ii) to broaden a student''s perspective of chemistry whilst developing their general transferable skills with a focus on communication and employability. (40% of module)

    Learning Outcomes

    The overarching leaning outcome is for students to have the key skills that will equip them to perform well in the rest of their chemistry degree programme.

    The learning outcomes can be divided into two areas: Quantitative and General Key Skills.

    Quantitative key skills:

    By the end of this module a successful student should be able to handle:

    • Simple volumetric calculations as required for titrations in analytical chemistry;
    • Basic algebraic manipulation and functions needed for kinetics, thermodynamics and quantum mechanics;
    • Elementary geometry required for the understanding of molecular shapes and solid state chemistry;
    • The representation of data via graphs, particularly straight line graphs, and the manipulation of data in spreadsheet programs for data analysis;
    • The basic idea of a derivative and an integral for use in physical chemistry;
    • The physical concepts of energy, momentum and angular momentum;

      ​​General key skills:

       

      By the end of this module a sucessful student will understand:

      • basic aspects of working safely in a chemistry laboratory;
      • aspects of chemical research;
      • the importance of chemistry in the development of our society;
      • chemical databases;
      • the need for academic integrity;
      • how chemistry can contribute to their transferable skills;

      In addition successful students will have developed their:

      • investigative, critical, writing and presentation skills;
      • chemical database skills;
      • employability skill.;
    • Introduction to Physiology and Pharmacology (LIFE106)
      Level1
      Credit level15
      SemesterSecond Semester
      Exam:Coursework weighting80:20
      Aims

      This module aims to:

      1. Provide students with a grounding in the concepts and principles that underlie human systems biology;
      2. Introduce the concepts of interactions of drugs and other exogenous chemicals on biological processes;
      3. Develop concepts of drug absorption and the relationship between chemical structure and drug action;
      4. Develop knowledge and understanding in physiology and pharmacology, and ability to apply, evaluate and interpret this knowledge to solve problems in these disciplines.
      Learning Outcomes

      On successful completion of this module, the students will be able to:

      1.  Describe homeostasis and its maintenance;
      2.  Define osmosis and hydrostatic pressure;
      3.  Outline the fundamentals of membrane potentials and how they are influenced;
      4.  Explain the roles played in various body systems in organism maintenance;
      5.  Distinguish how body systems interact in response to external stressors;
      6.  Define the way in which pharmacology is studied and drugs are developed;
      7.  Describe the properties of receptors;
      8.  Identify the chemical interactions between drugs and receptors;
      9.  Define and use the terms absorption, distribution and metabolism of drugs.

    Programme Year Two

    You will learn more advanced topics within all the main branches of Chemistry and continue to develop your Quantitative and Key Skills. Practical Chemistry skills will be developed through stand-alone modules and you will have the opportunity to spend between six and nine hours per week in the chemical laboratories. You will also take 22.5 credits of Pharmacology/Medicinal Chemistry modules that will involve both theoretical and practical aspects of the subject.

    Year Two Compulsory Modules

    • Metals and Metalloids of the P and D-blocks (CHEM214)
      Level2
      Credit level15
      SemesterSecond Semester
      Exam:Coursework weighting80:20
      Aims

      Aims:

      This module is an introduction to the co-ordination and organometallic chemistry of 3d transition metals, and will encompass theory, physical methods and descriptive chemistry.

      The aims of the module are:

      • To outline how bonding theories (valence bond, crystal field, ligand field) have been developed by chemists to rationalise important properties of the d–block elements, many of which distinguish them from organic and main group compounds
      • To illustrate the chemistry of the transition elements by a detailed study of three groups, Ti/Zr/Hf, Fe/Ru/Os and Ni/Pd/Pt, including:
        • Discovery, isolation and technological importance of the elements and their compounds
        • A survey of the chemistry of the different oxidation states and a comparison of the 3d elements with their heavier 4d and 5d relatives
        • Brief comparisons/contrasts with neighbouring groups of elements.
      • To introduce the theory underlying the use of appropriate physical and spectroscopic techniques for characterising d–block complexes, and examples of their application.
      • To introduce the chemistry, and some applications, of complexes in low oxidation states, including:
        • CO as an examplar of a p-acceptor ligand
        • 3d Metal carbonyl complexes
        • Analogous ligands, e.g. NO, RNC
        • The 18-electron rule; what it is, and why it applies to these complexes.
      • To introduce the chemistry, and some applications, of p-block elements and compounds.         

       

      Learning Outcomes

      By the end of the module students should:

      • Show an understanding of the concepts, applications and limitations of the different bonding theories relevant to transition-metal complex chemistry, and be aware of their relative relevance in different chemical contexts.
      • Be able to identify key elements of the structures of transition-metal complexes, and apply their knowledge of spectroscopic and physical techniques to work out the correct structure for a complex, given relevant chemical and spectroscopic information.
      • Be able to describe the social, economic and technological importance of selected transition elements.
      • Understand and be able to describe the significance of the syntheses, characterisation and chemistry of 3d metal complexes encountered in the practical module, CHEM245.
      • Understand the origin of the18-electron rule, its application and the sort of complexes to which it applies.
    • Organic Chemistry II (CHEM231)
      Level2
      Credit level15
      SemesterFirst Semester
      Exam:Coursework weighting80:20
      Aims

      The aim of this module is to introduce important carbon-carbon bond forming reactions within a mechanistic and synthetic framework, together with exposure to a selection of stereochemical issues.

      Learning Outcomes

      Students should be able to solve problems featuring:

      Scope and mechanisms of basic reactions (nucleophilic and electrophilic substitutions, addition and elimination reactions)

      Basic carbonyl chemistry (alkylation, acylation, aldol, conjugate additions).

      Structure, reactivity and synthesis of simple heterocycles (including pyridines, pyrroles, furans)

      Functional group interconversions and stereochemistry.

    • Preparative Chemistry: Synthesis and Characterisation (CHEM245)
      Level2
      Credit level15
      SemesterFirst Semester
      Exam:Coursework weighting0:100
      Aims

      The module aims to present a unified approach to the synthesis and characterisation of organic and inorganic compounds and will build on techniques introduced in the first year laboratory courses.

      Learning OutcomesStudents will complete a number of different experiments and synthetic techniques across synthetic, organic and inorganic chemistry.

      ​Students will appreciate how spectroscopic techniques can be used in the characterisation of organic and inorganic compounds and will be able to use analytical and spectroscopic methods to characterise their synthesised compounds.

      ​Students will make use of scientific databases during some assignments and an electronic report.

      ​Students will assess the risks inolved in chemical lab work and handle chemical materials in a safe manner.

      ​Students should be able to organise and plan their time effectively

      ​Students will experience working collaboratively with others in multiple learning environments

    • Measurements in Chemistry (CHEM246)
      Level2
      Credit level15
      SemesterSecond Semester
      Exam:Coursework weighting0:100
      Aims

      The aim of this module is to instruct students in the practice of taking physical measurements, the critical analysis and evaluation of experimental data, the application of measurements to the study of chemical phenomena and the dissemination of results.

      Learning Outcomes
      By the end of the module, students should be able to
      1.      take physical measurements of varying complexity using a wide range of experimental techniques;
      2.      assess the risks involved in chemical lab work and handle chemical materials in a safe manner;
      3.      choose appropriate methods for the analysis of data;
      4.      analyse experimental data using graphs, spreadsheets and linear regression;
      5.      assess the accuracy and significance of experimental results;
      6.      apply the results of physical measurement to the interpretation of chemical phenomena;
      7.      combine units and perform a dimensional analysis;
      8.      have experience of the application of spectroscopic techniques (UV, IR, NMR and mass spectrometry) in the characterization of organometallic and inorganic compounds;
      9.      organise and plan their time effectively.
    • An Introduction to Medicinal Chemistry (CHEM248)
      Level2
      Credit level7.5
      SemesterSecond Semester
      Exam:Coursework weighting90:10
      Aims

      The aim of this module is to introduce students to the fundamental principles that underpin modern medicinal chemistry, including an introduction to targets for drug action, methods of administration, qualitative and quantitative SAR, computer aided molecular design, solid phase chemistry /combinatorial chemistry.   The course also aims to describe in detail the chemical mechanisms of antitumour agents and will also include two lectures on carbohydrate chemistry.

      Learning Outcomes

      By the end of this module students are expected to have acquired an understanding of

      • The principle bonding interactions in drug receptor interactions
      • The basic concepts of structure activity relationships (SAR) and quantitative structure activity relationships (QSAR)
      • The principles behind computer aided molecular design and 3-D QSAR
      • Peptide synthesis, protecting groups and combinatorial chemistry
      • Chemical mechanisms of drugs that target DNA
      • Basic carbohydrate chemistry

      and will be able to use these concepts and principles to solve simple problems in medicinal chemistry.

    • Physical Chemistry II (CHEM260)
      Level2
      Credit level15
      SemesterWhole Session
      Exam:Coursework weighting80:20
      Aims
    • ​To explain the application of the 1st and 2nd laws of thermodynamics to chemical reactions.

    • ​To reinforce the basic ideas on factors affecting the rates of chemical reactions and quantify the kinetics.

    • To provide an introduction into basic concepts of quantum mechanics.​

    • ​To advance knowledge of quantitative analysis of molecular spectra.​
    • ​To make students familiar with the basic ideas of photochemistry.​

    • Learning Outcomes​Discuss the difference between ideal and real gases.

      ​Discuss the 1st and 2nd laws of thermodynamics in the context of chemical reactions.​

      Carry out thermochemical calculations involving enthalpy, entropy and Gibbs free energy.​
      ​Calculate equilibrium constants from thermodynamic data.

      ​Discuss the concept of the chemical potential and its application under ideal and non-ideal conditions.​
      ​Analyse experimental data for the determination of  reaction orders and rate coefficients, using appropriate methods depending on the type of data available.
      ​Derive and apply rate equations and integrated rate equations for 0th, 1st and 2nd order reactions. ​
      ​Show an understanding of activation barriers and apply the Arrhenius equation.​
      ​Describe qualitatively and quantitatively the kinetics of simple parallel, consecutive, and equilibration reactions. 
      ​Apply the pre-equilibrium and steady state approximations.​
      ​Describe different decay processes of photoexcited states and analyse them quantitatively.​
      ​Demonstrate an understanding of the basic concepts of quantum mechanics, including operators and wavefunctions.​
      ​Show an understanding of molecular energy levels and the forms of spectroscopy which involve transitions between them.​

      Compute basic properties of diatomics, eg bond lengths, from molecular spectra.​

      ​Use mathematical procedures and graphs for quantitative data analysis and problem solving.​

      ​Present and discuss the solution to problems in a small-group environment.​

    • Key Skills for Chemists 2 (CHEM280)
      Level2
      Credit level15
      SemesterWhole Session
      Exam:Coursework weighting10:90
      Aims
      1. To further develop the quantitative skills of a student, through more advanced skills in the application of mathematics, physics and information technology applicable to the second year of an undergraduate degree in chemistry. (50% of module)

      2. To introduce students to the use of Molecular Modelling in Chemistry *(35% of modules

      3. To further develop a student''s  general transferable skills in oral and written communication, presentation and team working. (15% of module). ​
      Learning Outcomes

      The overarching learning outcome is that students will gain the necessary key skills to perform well in their chemistry degree programmes.

      Quantitative key skills:By the end of the module a successful student will have improved their ability to:
      • perform basic calculus (integral and differential) as applied to kinetics, thermodynamics and quantum mechanics
      • use partial differentiation in general problems and to categorise stationary points in functions of more than one variable
      • apply algebraic manipulation in kinetics, thermodynamics and quantum mechanics
      • apply the algebra of complex numbers in quantum mechanics problems
      • use basic matrix vector algebra
      • solve simple eigenvalue problems and compute determinants of small matrices
      Molecular Modeling skills By the end of this module, a successful student will have gained:
      • a qualitative understanding of ab initio, semi-empirical and empirical models, knowing which model is suitable for a particular type of problem.
      • the ability to to predict the ground state energy and structure of isolated molecules (not too complicated) and estimate equilibrium constants (ΔH = ΔE) for simple reactions
      • the ability to rationalise some aspects of reactivity (charge density, frontier orbitals).
      • some experience of modelling intermolecular forces and complexes.

      General key skills:

      By the end of this module, a successful student will have improved:
      • knowledge of methods of presenting chemical research.
      • presentation skills
    • Principles of Pharmacology (LIFE207)
      Level2
      Credit level15
      SemesterFirst Semester
      Exam:Coursework weighting80:20
      Aims
    • This module aims to: Develop an understanding of the quantitative aspects of drug action on cellular receptors;

    • Demonstrate the relationship between drug efficacy and chemical structure;

    • Introduce the basic principles of pharmacokinetics, outline the relationship between drug concentration and response, and include an introduction to the principles of toxicity of drugs and their metabolites;

    • Provide knowledge of the molecular biology of receptors;

    • Develop knowledge and understanding in pharmacology, and the ability to apply, evaluate and interpret this knowledge to solve pharmacological problems.

    • Learning OutcomesOn successful completion of this module, the students should be able to: Describe quantitative aspects of drug action;​Define the relationship between drug efficacy and chemical structure;​State key pharmacokinetic concepts such as clearance, volume of distribution, half life and steady state and to solve problems involving these parameters;​Demonstrate the role of drug concentrations in determining response to treatment;​Describe early biochemical events after drug administration that are of toxicological and biochemical significance;​Describe the principles of selective toxicity and their application to both self and non-self targets;​Demonstrate knowledge and critical understanding of the principles of pharmacology, and how this knowledge has been applied to solve problems.​

    Programme Year Three

    In Year Three, you further develop your skills in Organic and Inorganic Chemistry as well as taking 30 credits of Pharmacology modules.

    Year Three Compulsory Modules

    • Further Inorganic Chemistry (CHEM313)
      Level3
      Credit level15
      SemesterFirst Semester
      Exam:Coursework weighting80:20
      Aims

      The aims of the module are:

      • To explain the mechanisms by which transition metal complexes exchange ligands, and how they participate in redox reactions.
      • To outline and rationalise the chemistry of complexes with metal-alkyl and metal-carbene bond
      • To outline and rationalise the chemistry of transition-metal complexes containing metal to carbon s-bonds, eg metal-alkyl, metal-acetylide, metal-vinyl, and metal-carbene complexes
      • To show how metals coordinate to compounds such as alkenes, alkynes, allyls and conjugated p-systems CnHn (n = 5 to 8) via interactions with the C-C multiple bonds
      • To provide an introduction to the structures of solid state materials and the role of diffraction in studying these structures
      • To explain how electrons behave in extended structures, with particular reference to the distinction between metals and insulators, and the behaviour of doped semiconductors. 
      Learning Outcomes

      By the end of the module, students should be able to:

      • Demonstrate an understanding of the role of ligand field and other factors in determining how metal complexes undergo ligand exchange, and how they undergo electron transfer.
      • Appreciate the bonding of different organic fragments to transition metals and how a variety of physical measurements can be used to substantiate these ideas.
      • Demonstrate an understanding of the concepts of infinite solids and their diffraction of X-rays
      • Appreciate the factors affecting the electronic properties of solids.
    • Further Organic Chemistry (CHEM333)
      Level3
      Credit level15
      SemesterFirst Semester
      Exam:Coursework weighting80:20
      Aims

      The aim of the course is to extend second year knowledge of synthetic and physical organic chemistry.

      Learning Outcomes

      By the end of the module, students should:

      • Have a good understanding of modern synthetic reactions and their mechanisms.
      • Be able to deduce mechanisms on the basis of kinetic and other evidence.
    • Medicinal Chemistry of Anti-infectives (CHEM335)
      Level3
      Credit level7.5
      SemesterFirst Semester
      Exam:Coursework weighting90:10
      Aims

      The aim of this module is to introduce students to the fundamental principles that underpin modern medicinal chemistry of anti-infective drugs and will include qualitative and advanced quantitative SAR techniques, computer aided molecular design, further techniques in solid phase chemistry / combinatorial chemistry.  The course will build on the principles taught in the introductory medicinal chemistry course Chem 248. 

      Learning Outcomes

      By the end of the module students will have achieved a solid foundation of modern approaches to anti-infective drug design.

      In particular they should be able to show a clear understanding of:

      • The mechanism of action, design and synthesis of b-lactam antibiotics, cephalosporins and carbapenems.
      • Antiviral drug design
      • The importance of protease enzymes as drug targets as illustrated by examples including the falcipain 2 inhibitors (cysteine proteases) and HIV protease inhibitors (aspartate proteases).
      • Advanced techniques in computational drug design and combinatorial chemistry.
    • Heterocyclic Chemistry and Drug Synthesis (CHEM338)
      Level3
      Credit level7.5
      SemesterSecond Semester
      Exam:Coursework weighting80:20
      Aims

      To present the synthesis and reactivity of the most important classes of heterocyclic compounds and to present case studies drawn from major drug classes.

      Learning Outcomes

      By the end of the module students will have achieved a solid foundation in Organic Chemistry.

      In particular they will be expected to be able to demonstrate a clear understanding of

      • The structural features and reactivity of heterocyclic compounds, including stereochemistry.
      • Some of the major synthetic pathways in heterocyclic chemistry, involving carbon-carbon and carbon-heteroatom bond formation, functional group interconversions and ring substitution.
      • Awareness of the importance of heterocylcles as key components in major drug classes and combinatorial libraries.

      In addition they will be able to give examples of their use in modern synthetic methodology and have an awareness of the importance of three-dimensional structure in Organic Chemistry.

    • Practical Chemistry for MChem Students - Shorter Version (CHEM355)
      Level3
      Credit level15
      SemesterFirst Semester
      Exam:Coursework weighting0:150
      Aims

      In this module, students will spend four weeks carrying out advanced experimental work in the areas of Organic, Organometallic and Physical Chemistry.

      The general aims of the module are:

      • To give the student practical experience and understanding of advanced practical techniques for Organic, Organometallic and Physical Chemistry.
      • To develop appropriate techniques for each type of experiment
      • To show the use of appropriate characterisation techniques
      • To familiarise the student with the preparation of written reports
      • To establish a close link with aspects of the lecture material covered in the Yr 3 course
      Learning Outcomes

      By the end of the module, students should be able to

      • Carry out advanced practical techniques in the areas of Organic, Organometallic and Physical Chemistry
      • Give a reasoned written exposition of experimental work and achievements
      • Make valid deductions from acquired data
      • Be capable of giving comprehensible written accounts of experimental work
      • Demonstrate an understanding of shortcomings, experimental errors or weaknesses in data
      • Further develop their time management skills via coordination of the synthetic and analytical components of their experiments
      • Show that they understand the wider social or technological relevance of their work
    • Practical Chemistry Project Year 3 - An Introduction to Research Methods in Chemistry (CHEM366)
      Level3
      Credit level15
      SemesterSecond Semester
      Exam:Coursework weighting0:100
      Aims

      This module is an MChem level Year 3 mini research project with the aim of introducing students to research methods in chemistry through an extended project. In this module, students will be assigned an extended experiment on asynthetic (organic or inorganic), physical (catalysis, electrochemistry,surface science, modelling, nanoparticles) or interdisciplinary theme,according to their own interests and abilities, and therefore the aims of the module will differ slightly according to topic.

      The general aims of the module are:

      • To give the student a taste of research in a contemporary area of chemistry
      • To develop of appropriate experimental technique for the topic undertaken
      • To show the use of appropriate characterisation techniques
      • To illustrate the use of the library and other information resources as research tools
      • To familiarise the student with the preparation of written reports
      • To teach the skills necessary for the preparation and delivery of a short oral presentation.
      Learning Outcomes

      By the end of the module, students should be able to:

      • Give a reasoned written exposition of experimental work and achievements
      • Make valid deductions from acquired data
      • Be capable of giving comprehensible written and oral accounts of experimental work
      • Demonstrate an understanding of shortcomings, experimental errors or weakness in data
      • Show that they understand the wider social and/or technological relevance of their work
    • Chemical Database Skills (CHEM385)
      Level3
      Credit level7.5
      SemesterFirst Semester
      Exam:Coursework weighting0:100
      Aims

      Chemical database skills and molecular modelling are becoming resouces now in common use by practicing chemical scientists. This module aims to introduce students to these skills through lectures and computer based workshop sessions. In this module, students will will attend six lectures and six practical sessions in chemical database skills and database skills. The general aims of the module are:

      • To establish a close link with aspects of the lecture material covered in the Yr 3 course
      • To introduce students to chemical database skills, including on-line searching of literature, citations, chemical reactions and structures.

      (students CANNOT take this module if they are taking CHEM375!)

      Learning Outcomes

      By the end of the module, students should be able to

      • Use scientific databases effectively for literature and citation searches.
      • Find relevant information from on-line chemical databases regarding chemical reactions and structures.
      • Be able to apply the database skills in writing a report drawing from scientific literature.
    • Protein Structure and Dynamics (CHEM452)
      LevelM
      Credit level7.5
      SemesterSecond Semester
      Exam:Coursework weighting90:10
      Aims

      The aim of this module is to discuss the application of basic physical chemistry concepts for describing protein structure and dynamics and to show how advanced physical chemistry methods are used for investigating these important aspects of proteins.

      Learning Outcomes

      Ability to discuss the importance of protein structure and dynamics for understanding biological processes.

      Ability to describe the experimental methods that are used to study structure, folding and fast dynamics of proteins.

      Ability to discuss the physical chemistry principles underlying these methods and apply the basic equations needed for the analysis of such data.​

      Ability to describe and discuss some of the theoretical methods that are used to predict protein structure and and model protein folding/dynamics.​

      Ability to analyse PDB-structure files and create meaningful graphical representations from these files.​

    • Antimicrobial Chemotherapy for Chemists (LIFE348)
      Level3
      Credit level15
      SemesterSecond Semester
      Exam:Coursework weighting80:20
      Aims

      ​1) To reinforce the relevance and importance of the principles of chemotherapy learned in year two (antibacterial chemotherapy).

      2) To extend the   application of chemotherapy principles to diseases caused by viruses (e.g. HIV/AIDS) and parasites (i.e. malaria)

      3) To introduce novel concepts in drug design (Nanomedicine) and treatment strategy (Pharmacogenomics) in the context of chemotherapy.

      4) To illustrate the importance of chemical structure and structure-based drug design in drug action.

      Learning Outcomes

      ​​Critically evaluate how the principles of selective toxicity may be applied to the chemotherapy of infectious diseases

      ​Discuss the clinical relevance of basic pharmacological principles of chemotherapy

      ​Discuss the importance of drug resistance in the treatment and prevention of disease

      ​Evaluate the importance of structure activity relationship (SAR) in modern drug design in the context of chemotherapy 

    • Drug Action (LIFE206)
      Level2
      Credit level15
      SemesterSecond Semester
      Exam:Coursework weighting100:0
      Aims
      1. Enable students to develop their understanding of the cardiovascular, endocrine and central nervous systems and the mechanisms by which drugs interact with physiological processes operating within each of these systems;​​
      2. Provide an insight into the mechanisms of immune function and dysfunction, and the actions of drugs that target the immune system;
      3. Give students a grounding in the fundamental principles of signal transduction from metabotropic receptors, and their significance for drug action;​
      4. Provide and overview of the overall drug development process, with a focus on the safety and efficacy tests applied during clinical trials, and the value-for-money tests applied during NICE approval;
      5. Develop knowledge and understanding in pharmacology, and ability to apply, evaluate and interpret this knowledge to solve problems.
        Learning Outcomes

        ​Identify the effects of drugs on the CNS and demonstrate an understanding of how drugs may be used to treat neurological and neuropsychiatric disorders;

        ​Describe the action of drugs in the cardiovascular system and their role in the treatment of cardiovascular disease;

        Compare the effects of drugs on the kidney, the endocrine system and the gastrointestinal tract;Describe the principles underlying the effects of drugs on the immune system and the treatment of autoimmune disease;​Apply knowledge how the signal transduction pathways can be modulated to enhance cancer therapy;​

        Apply the knowledge of the regulatory framework underlying the testing and approval of drugs;

      Programme Year Four

      The final year of this programme is more focussed on the Chemistry of pharmaceutical synthesis and related Pharmacology than the standard Chemistry MChem Chemistry (F102) programme.

      You will take 30 credits of pharmacology modules, the core Organic Chemistry modules and a choice of 15 credits of Chemistry optional modules from level M.

      The Chemical Research Project is dominant, accounting for 60 of the 120 credits. Students choose a research project with groups in Organic and Medicinal Chemistry (including medicinal applications of nanotechnology), or in Pharmacology.

      Year Four Compulsory Modules

      • Main Group Organic Chemistry 1: C Option (CHEM431)
        LevelM
        Credit level7.5
        SemesterFirst Semester
        Exam:Coursework weighting100:0
        Aims

        The aim of this module is to broaden and extend the knowledge of modern Organic Chemistry so that students will be able to enter directly into a PhD or embark on a career as a specialist chemist.

        Learning Outcomes

        By the end of the module students will have achieved a solid foundation in Organic Chemistry. In particular they will have a clear understanding of

        • Main Group Organic Chemistry
        • Organopalladium Chemistry
        and be able to give examples of their use in modern synthetic methodology.
      • Asymmetric Synthesis and Synthetic Strategy (CHEM433)
        LevelM
        Credit level7.5
        SemesterFirst Semester
        Exam:Coursework weighting100:0
        Aims

        The aim of this module is to further broaden and extend the knowledge of modern Organic Chemistry so that students will be able to enter directly into a PhD or embark on a career as a specialist chemist.

        Learning Outcomes

        By the end of the module students will have achieved a solid foundation in Organic Chemistry. In particular they will have a clear understanding of

        (a) stereocontrolled synthesis

        (b) main strategies in organic chemistry

        and be able to give examples of their use in modern synthetic methodology.

      • Chemical Research Project (CHEM480)
        LevelM
        Credit level60
        SemesterWhole Session
        Exam:Coursework weighting0:100
        Aims

        The aim of this module is to develop the skills necessary to undertake independent research.

        Learning Outcomes

        By the end of this module students will have:

        • Acquired advanced laboratory skills.
        • Developed an ability to work independently and be self-critical in the evaluation of risks, experimental procedures and outcomes.
        • Extended their written and oral communication skills.
        • Extended their information-technology skills.
        • Acquired time-management and organisational skills.
        • Acquired competence in the planning, design and execution of experiments.
        • Acquired the ability to use an understanding of the limits of accuracy of experimental data to inform the planning of future work.

        Students will

        • Be able to predict the ground state energy, structure  and properties of isolated molecules (for relatively simple systems).
        • Be able to estimate equilibrium constants, rate constants and calculate transition states (for simple reactions).
        • Be able to rationalise aspects of reactivity (charge density, frontier orbitals).
        • Have some understanding of intermolecular forces and complexes (pharmacological example)
        • Be able to judiciously apply molecular modelling to their research projects
      • Cancer Pharmacology for Medicinal Chemists (LIFE402)
        LevelM
        Credit level7.5
        SemesterSecond Semester
        Exam:Coursework weighting80:20
        Aims

        This module aims to: Provide an explanation of current understanding of cancer development and progression and how this is exploited in the rational design of drugs to target cancer Explain the latest knowledge of the molecular mechanisms of anti-cancer drugs and the potential for side-effects and drug-resistance. Critically evaluate the clinical effectiveness and cost-effectiveness of modern cancer drugs.
        Learning Outcomes

        ​Define in detail, the pathophysiological process of cancer development and progression

        ​Critically evaluate the rationale for the design and mechanism of action of anti-cancer agents

        ​Describe current ideas on the mechanisms of drug-resistance in cancer therapy

        ​Critically evaluate scientific literature and clinical data regarding the efficacy and cost-effectiveness of anti-cancer therapy in patients

        ​Synthesise information, critically review evidence to support conclusions, and define complex problems by applying appropriate knowledge and skills

      • Drug Metabolism and Response (LIFE403)
        LevelM
        Credit level7.5
        SemesterFirst Semester
        Exam:Coursework weighting80:20
        Aims

        1. ​To demonstrate therelevance and importance of the principles of drug metabolism andpharmacokinetics

        2. ​To explain theimportance of the relationship between drug disposition and drug response

        3. ​​​​To developin students the ability to apply, critically evaluate and interpret thisknowledge and understanding, to solve complex problems in pharmacology

        Learning Outcomes

        ​​To appraise the principles of drug disposition and drugresponse, particularly in relation to why subjects differ in their response todrugs

        ​​To critically discuss the relevance of basic pharmacokinetic principles to achieving a good response to therapy

        ​​​To critically analyse pharmacokinetic data

        ​​​To evaluate the dispositional basis of adverse drug reactions

      Year Four Optional Modules

      • Organic Electronics (CHEM492)
        LevelM
        Credit level7.5
        SemesterSecond Semester
        Exam:Coursework weighting100:0
        Aims

        The aims of the module are:

        1. To show students how semiconducting organic molecules and materials can be designed and synthesised for use in a wide range of electronic devices, such as organic light-emitting diodes, thin film transistors, photovoltaic devices and sensors.

        2. To introduce the students to current topics of interest in the field of molecular electronics, the science of incorporating single molecules into electrical circuits.

        Learning Outcomes

        By the end of the module, students should:

        Be familiar with important structure-property relationships in pi-conjugated materials, and how these relate to their uses as organic semiconductors in different electronic devices.

        Be aware of synthetic routes to the materials, and how these can limit or control their properties.

        Be familiar with important parameters used to assess the performance of various organic electronic devices, such as OLEDs, OTFTs and OPVDs.

        Be aware of current and possible future industrial applications of this new technology.

        Be aware of concepts underlying experiments to determine the electrical properties of single molecules, and of the significance of these measurements.

        Be able to read and understand review papers from the literature in these areas.

      • Chemical Nanotechnology (CHEM494)
        LevelM
        Credit level7.5
        SemesterSecond Semester
        Exam:Coursework weighting100:0
        Aims

        The aims of this module are:

        • To introduce the student to some current problems and challenges of materials chemistry.
        • To provide the student with knowledge of important experimental methods in nanostructure research.
        • To create an appreciation for applied aspects of research in this area.
        Learning Outcomes

        By the end of the module, students should:

        • Understand the concept of Self-assembly.
        • Have an overview of chemical and materials aspects of nanotechnology.
        • Be acquainted with metal, semiconductor and carbonaceous nanostructures.
        • Know the basics of TEM, STM and AFM
        • Be able to comment critically on prospective applications of nanostructured materials.
      • Asymmetric Catalysis for Organic and Pharmaceutical (CHEM496)
        LevelM
        Credit level7.5
        SemesterSecond Semester
        Exam:Coursework weighting100:0
        Aims

        To introduce students to the main aspects of asymmetric catalysis and its application in synthetic organic chemistry.

        Learning Outcomes
        • An understanding of the importance of asymmetric catalysis.
        • An understanding of the fundamental principles and mechanisms of asymmetric catalysis.
        • An understanding of the applications of asymmetric catalysis in fine chemicals and pharmaceutical synthesis.  
        • An opportunity to consider new developments in the field, especially those that underpin new environmentally benign processes.
      • Introduction to Nanomedicine (CHEM426)
        LevelM
        Credit level7.5
        SemesterSecond Semester
        Exam:Coursework weighting80:20
        Aims

        The aims of the module are to:

        •To explain colloidal/self-assembling systems in detail and their role in nanomedicine. •Inform about the state of the art of materials for nanomedicines and the synthetic routes used.•To explain the pharmacological behaviour of nanomedicines and how different diseases require different approaches for successful treatment.

         

        Learning Outcomes

        Students should be able to show that they can define and explain colloidal systems and name examples of different colloids. They should demonstrate a detailed understanding of how colloidal stability can be obtained, and explain and utilise the principles behind calculating colloidal stability.

        ​Students should be able to describe the different types of nanomedicines and discuss the range of advanced synthetic routes used to produce different nanomedicine structures for oral and injectable administration. They should understand the differences between conjugated and non-conjugated delivery systems, including self-assembled nanostructures and be able to explain the advanced methods available for the characterisation of nanomedicines.

        ​Students will understand the principles behind pharmacokinetics and the importance of these principles to nanomedicine. They will understand the different routes of administration used to deliver nanomedicines and be able to explain how different diseases present different challenges to drug delivery and how nanomedicines can be desgined to targets specific diseases.

        Students will be able to examine the state of the art for nanomedicines and discuss the future research directions. ​

      • Solid State Chemistry and Energy Storage Materials (CHEM442)
        LevelM
        Credit level7.5
        SemesterSecond Semester
        Exam:Coursework weighting60:40
        Aims

        ​Theaims of the module are:

        • To provide an introduction todiffraction methods for the characterisation of solid state materials.
        • To introduce the students tothe concepts and applications of symmetry in the solid state.
        • To provide an introduction tothe structures of solid state materials and their description and phasetransitions.
        • To provide a perspective onthe ranges of properties displayed by solids, particularly cooperativemagnetism, ferroelectricity, and multiferroicity and their relationships tostructure and symmetry.
        • To introduce the rich chemistry of insertionmaterials and highlight their relevance in energy applications.
        • To demonstrate the importance of defect chemistry with particular relevance to energy materials.
        • To provide a basic understanding of superconductivityand the chemistry of superconducting materials.​ 

        Learning Outcomes

        ​Students will be able to demonstrate an understanding of the application of diffraction methods to the characterisation of key material types in the solid state.

        ​Students will become familiar with a range of properties displayed by solids, particularly cooperative magnetism, ferroelectricity and multiferroicity, and how these relate to structure and symmetry.

        ​Student will be able to demonstrate a grasp of the importance of intercalation/insertion chemistry in energy storage applications (batteries).

        ​Students will develop the ability to relate fundamental concepts of diffraction, characterisation etc. in solid state chemistry to prctical applications in energy storage and related materials.

      • Application of Enzymes in Organic Synthesis €� Industrial Biotechnology (CHEM486)
        LevelM
        Credit level7.5
        SemesterSecond Semester
        Exam:Coursework weighting100:0
        AimsThe aim of this module is to provide students with a knowledge and understanding of the application of enzymes and how to apply them in organic synthesis​.  Students will gain insight into modern methods of mutagenesis for enzyme optimisation and also cutting edge approaches to designing artifical enzymes and assemblage of cascade pathways for synthesis.
        Learning Outcomes

        Bythe end of the module, students should be able to:

         

         •   Understand how enzymes can be applied in organicsynthesis.

         •   Demonstrate a knowledge of how genes encode enzyme 3Dstructure

         •   Understand factors governing the selection ofbiocatalyst and biocatalyst type.

         •   Show an understanding of cofactor requirements andrecycling strategies in redox biotransformations.

         •   Show a knowledge of the advantages and limitations inthe application of biocatalysts.

                   •      Demonstrate a knowledge of enzyme immobilizationmethods.

                   •   Show an understanding of the use molecular biology formutagenesis 

            and directed evolution methods to improve enzyme activity or 

                      selectivity.

                   •   Have an appreciation of new approaches for creatingartificial    enzymes.


         •​  Understand how enzymereactions can be assembled into multistep cascade synthetic pathways.
      • Modelling of Functional Materials and Interfaces (CHEM454)
        LevelM
        Credit level7.5
        SemesterSecond Semester
        Exam:Coursework weighting50:50
        Aims
      • ​To provide students with an introduction to modern computational chemistry methods and concepts for functionalmaterials and interfaces. These methods will include primarilydensity functional theory methods for electronic structure but alsoan orientation towards wave function methods and classical moleculardynamics methods combined with force fields. 

      • ​To understand how computational modelling can be used in research and development of functional materials and interfaces

      • ​To be able to assess results from such computational modelling

      • ​To prepare students tocarry out competitive postgraduate research in Computational and Theoretical Chemistry, Materlals Chemistry, and Functional Interfaces

      • Learning Outcomes

        P{margin-bottom:0.21cm;}P.western{;} To describe the role and merits of wave function versus density methods

        ​To describe some basic concepts of density functional theory such as: exchange-correlation functionals including some of their shortcomings and Kohn-Sham states

        ​To gain a basic understanding of the behaviour of electrons in periodic structures: solids and interfacesP{margin-bottom:0.21cm;}P.western{;}

        ​To be able to apply tight binding/Huckel to some simple situations

        To describe what can be learnt from computation of total energies and forces​

        To describe origin of interatomic and molecular forces and relate them to electronic structure

        ​To gain an understanding of force fields and their applicability

        To describe the basics of classical molecular dynamics and thermostats​

      • Nuclear Magnetic Resonance Spectroscopy (CHEM474)
        LevelM
        Credit level7.5
        SemesterSecond Semester
        Exam:Coursework weighting80:20
        Aims

        This is an advanced module that aims to introduce the student tomodern nuclear magnetic resonance (NMR) spectroscopic techniques and theirapplications in analytical chemistry. The students will be able tounderstand the basic physical principles of NMR and to decide howto use it to tackle a particular problem of molecules and materialscharacterisation.  

        In particular, the module will deal with- the principles ofnuclear magnetic resonance, including modern methods for the determination ofchemical structure and intermolecular interactions in complex organicmolecules, polymers and solids as well as the concept of electron paramagneticresonance spectroscopy;

        Learning Outcomes​​By the end of the module, successful students should have gainedan in-depth understanding of NMR (and EPR) and be able to explain the physicalprinciples of these spectroscopies, analyse spectra and be able to discusstheir suitability to address certain problems of materials characterisation. Inparticular, successful students should be able to:

        - Discuss the behaviour of nuclear spins and theirensembles in an external magnetic field and the influence of magneticinteraction on the appearance of NMR spectra;

        - Describe the structure of modern NMR spectrometers,explain the concepts of data acquisition and processing and show anunderstanding of chemical shift, magnetisation, rotating frame of reference,scalar coupling and basic pulse programming;

        - Explain the origins of relaxation, the principles of the determinationof T1 and T2 relaxation times, their calculation from NMRdata, and the relationship between relaxation and molecular motion.

        - Explain the nuclear Overhauser effect and its use inanalysis of complex organic molecules;

        - Describe the main principles of one- and two dimensionalexperiments and interpret the spectra recorded for both liquids and solids;

        - Explain the differences in acquisition of solution andsolid-state NMR spectra and specific methods used for solids (magic anglespinning, cross-polarisation and decoupling);

        - Describe experiments suitable for the analysis ofinternuclear connectivites, distances and mobility in organic and inorganicsolids;

        - Understand the concept of electron paramagnetic resonance(EPR) spectroscopy;

        - Critically compare different methods of spectroscopy andtheir suitability to tackle a particular problem in materials characterization;

        - Critically evaluate the use of spectroscopy to support scientificconclusions based on literature.​

      The programme detail and modules listed are illustrative only and subject to change.


      Teaching and Learning

      Laboratory classes in Years One and Two prepare you for independent laboratory work in Years Three and Four. In Year Three you will carry out mini research projects, while in Year Four you will carry out research alongside PhD and postdoctoral researchers on cutting-edge projects, often leading to a first scientific publication. Computational modelling and molecular visualisation are introduced as interactive animated models from Year One, reinforced as a key skill in later years and by Year Four of MChem programmes you will be able to perform your own calculations to underpin final year research projects.


      Assessment

      You are assessed by examination at the end of each semester (January and May/June) and by continuous assessment of laboratory practicals, class tests, workshops, tutorials and assignments. You have to pass each year of study before you are allowed to progress to the following year. Re-sit opportunities are available in September at the end of Years One and Two. If you take an industrial placement, a minimum standard of academic performance is required before you are allowed to embark on your placements. You are expected to perform at a 2:1 level if you wish to continue on a MChem programme. All years of study (with the exception of Year One) contribute to the final degree classification.