Signalling

Protein sulfation enzymes are targeted by kinase inhibitors

Byrne DP, Li Y1, Ngamlert P, Ramakrishnan K, Eyers CE, Wells C, Drewry DH, Zuercher WJ, Berry NG, Fernig DG, Eyers PA. (2018) New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors. [PUBMED] [PDF] [Abstract...]

Enzymes for carbohydrate sulfation are targeted by kinase inhibitors

Dominic P. Byrne, Yong Li, Krithika Ramakrishnan, Igor L. Barsukov, Edwin A. Yates, Claire E. Eyers, DulceĢ Papy-Garcia, Sandrine Chantepie, Vijayakanth Pagadala, Jian Liu, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig and Patrick A. Eyers (2018) New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors [PDF] [PUBMED] [Abstract...]

Role of CDK18 in replication stress signalling and genome stability

Barone G, Staples CJ, Ganesh A, Patterson KW, Bryne DP, Myers KN, Patil AA, Eyers CE, Maslen S, Skehel JM, Eyers PA, Collis SJ. (2016). Human CDK18 promotes replication stress signaling and genome stability. [PUBMED] [PDF] [Abstract...]