Dr Edward Emmott BSc (Hons), PhD
Reader/Wellcome CDA Fellow Biochemistry, Cell and Systems Biology
- +44 (0)151 795 1232 Ext. 1232
- Work email E.Emmott@liverpool.ac.uk
- Personal WebsiteLab website
- ORCID0000-0002-3239-8178
Research
Research Overview
My lab is interested in the study of virus-host interactions and virus replication for RNA viruses, especially where the replication of these viruses is governed by proteolytic cleavage and the impact of viral proteases on the host cell. These include the coronaviruses and noroviruses. We develop and apply mass spectrometry-based proteomic methods in support of this research. An example would be the development and application of single-cell proteomics by mass spectrometry methods, having helped develop the SCoPE2 carrier/reference approach being adopted internationally across different single-cell proteomics approaches. The ultimate goal of our research is to identify and characterize virus-host interactions and replication mechanisms that can be targeted to inhibit virus replication as an antiviral strategy.
RNA virus replication & Single-cell proteomics
Viral proteases and their targets
Proteomics methods development
Research Grants
Coronaviruses: linking polyprotein processing and replication complex function’
WELLCOME TRUST (UK)
December 2023 - March 2032
NovaseqX at Centre for Genomics Research
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
August 2023 - July 2024
Analysis of biomarkers to complement wearable technology
DEFENCE SCIENCE & TECHNOLOGY LABORATORY (UK)
February 2023 - September 2025
Uncovering cellular substrates of 3C-like proteases to identify conserved virus-host interactions as antiviral targets
MEDICAL RESEARCH COUNCIL
November 2022 - November 2025
A cellenONE BSC to enhance UK capability for single-cell proteomics
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
July 2022 - July 2023
REIMS Proof of Concept - Age Grading Mosquitoes
INNOVATIVE VECTOR CONTROL CONSORTIUM (IVCC) - (UK)
April 2021 - December 2022
The utility of sputum proteomics to test response to CFTR modulator therapy
NORTH WEST LUNG CENTRE CHARITY (UK)
January 2022 - January 2024
Understanding proteolytic cleavage of host proteins during avian coronavirus infection
HOUGHTON TRUST (UK)
October 2021 - September 2022
COVID-19: Molecular mapping of SARS-Cov2 and the host response with multiomics mass spectrometry to stratify disease outcomes for therapeutic and diagnostic interventions.
UK RESEARCH AND INNOVATION
October 2020 - April 2022
Investigating the role of GOLGA3 cleavage during SARS-CoV-2 infection
ROYAL SOCIETY
March 2021 - March 2022
Exploiting and advancing single-cell proteomics to identify novel pathways to disrupt RNA virus infection.
THE ACADEMY OF MEDICAL SCIENCES (UK)
May 2021 - May 2024
Ultra-sensitive Proteomics Platform
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
August 2020 - August 2021