Photo of Professor Paul O'Neill

Professor Paul O'Neill BSc Hons PhD CChem MRSC

Professor Chemistry

    Research

    Synthetic Organic Chemistry

    Research Group Membership

    Research Grants

    Development of non-covalent binders to SOD1 with scope for developing as PROTAC degraders of SOD1 for the treatment of MND

    MOTOR NEURONE DISEASE ASSOCIATION (UK)

    October 2023 - January 2027

    Phase II Clinical Development of AWZ1066S, a Small Molecule anti-Wolbachia Candidate Macrofilaricide Drug

    GLOBAL HEALTH INNOVATIVE TECHNOLOGY FUND - GHIT (JAPAN)

    October 2022 - September 2024

    Defining the two-step relay mechanism of action of the 8-aminoquinolines: A precondition for optimal combination therapies for relapse malaria

    MEDICAL RESEARCH COUNCIL

    September 2021 - September 2024

    Drug discovery to inhibit cyclophilin D as a treatment for acute pancreatitis

    LAP RESEARCH (UK)

    September 2022 - August 2024

    Design and development of novel SOD1 degraders for the treatment of Motor Neurone Disease

    ROYAL SOCIETY OF CHEMISTRY (UK)

    September 2022 - August 2023

    An anti-Wolbachia azaquinazoline small molecule as a preventative drug candidate for veterinary heartworm disease

    ROYAL VETERINARY COLLEGE(UK)

    November 2021 - September 2022

    Optimisation of the Antimalarial and DMPK Properties of A Series of Plasmepsin IX/X Beta-hydroxyethylamine Based Inhibitors

    LIVERPOOL SCHOOL OF TROPICAL MEDICINE (UK)

    March 2021 - August 2022

    New combination therapy against MDR TB targeting the respiratory chain

    MEDICAL RESEARCH COUNCIL

    March 2019 - February 2022

    LSTM MRC-CiC Determining the potency of hybrid antibiotics, informed by collateral sensitivity networks, against a panel of susceptible and resistant clinical Escherichia coli isolates.

    LIVERPOOL SCHOOL OF TROPICAL MEDICINE (UK)

    October 2018 - October 2019

    Development of Small Molecule Inhibitors of the Mitochondrial Electron Transport Chain of Plasmodium falciparum

    DEPARTMENT FOR BUSINESS, ENERGY AND INDUSTRIAL STRATEGY (BEIS) (UK)

    March 2018 - January 2021

    Pre-Clinical Development of small molecule anti-Wolbachia candidate macrofilaricide drug

    MEDICAL RESEARCH COUNCIL

    September 2018 - September 2020

    A new generation of Crystallographic detector for Multi-user Barkla X-ray laboratory

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

    July 2017 - July 2018

    Rational Design, Synthesis and Biological Evaluation of Benzimidazoles Towards a Novel Therapy Selectively Targeting C. neoformans beta-tubulin

    MEDICAL RESEARCH COUNCIL

    July 2016 - December 2019

    Positive Allosteric Modulators of Strychnine-Sensitive Glycine Receptors – A New Concept in Treating Chronic Pain

    MEDICAL RESEARCH COUNCIL

    September 2012 - February 2015

    A new drug target against Malaria

    LEVERHULME TRUST (UK)

    June 2006 - May 2009

    Resistant Breaking Insecticides - Project New Pyrethroids

    BAYER CORPORATION (USA)

    December 2007 - December 2011

    Synthesis and Biomimetic Chemistry of Novel Antimalarial Endoperoxide Cysteine Protease Inhibitor (ECPI) Pro-Drugs.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

    September 2000 - August 2003

    400 MHz NMR Spectrometer.

    ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL

    March 2000 - February 2003

    Alternative complex 1 as a drug target in malaria

    WELLCOME TRUST (UK)

    December 2008 - September 2011

    Lead Series Development & Optimisation af a New Drug Against Active and Latent Tuberculosis.

    MEDICAL RESEARCH COUNCIL

    October 2011 - March 2014

    Defining the mechanism of action of the 8-aminoquinolines: A pre-requisite to rationally designed safe antimalarials for the elimination era

    MEDICAL RESEARCH COUNCIL

    August 2014 - December 2016

    University of Liverpool Institutional Discipline Bridging.

    MEDICAL RESEARCH COUNCIL

    October 2003 - October 2006

    Quantitative high-throughput proteomics for biomedical research.

    MEDICAL RESEARCH COUNCIL

    March 2005 - March 2008

    Synthesis and biological evaluation of primaquine metabolites: implications of safety and efficacy

    MEDICINES FOR MALARIA VENTURE (SWITZERLAND)

    July 2014 - July 2015

    Cloning and characterisation of enzymes required for the in vitro synthesis of the antimalarial artemisinin.

    MEDICAL RESEARCH COUNCIL

    September 2002 - August 2003

    Probing the molecular mechanism of action of novel antimalarial falcipain 2 inhibitor endoperoxide pro-drugs in isolated parasite digestive vacuoles.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

    March 2005 - February 2008

    Development of New Drugs for the Treatment of Malaria (ANTIMAL)

    EUROPEAN COMMISSION

    December 2005 - May 2011

    TCAMS triazole series as potential serine protease inhibitors.

    TRES CANTOS OPEN LAB FOUNDATION (UK)

    October 2012 - September 2014

    Bridging and accelerating the translation of novel scientific findings for health and wealth gain

    MEDICAL RESEARCH COUNCIL

    March 2014 - August 2015

    KEL09/13 - Molecular design and chemoinformatics: A combined approach to novel molecules

    ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL

    December 2010 - March 2012

    Towards a 21st Century Replacement for the 4-Aminoquinoline Chloroquine

    ROYAL SOCIETY (CHARITABLE)

    July 2006

    Co(II)L2 Mediated Catalytic Aerobic Asymmetric Peroxysilylation and Hydration of Unactivated Alkenes.

    ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL

    November 2000 - October 2002