Photo of Prof Paul O'Neill

Prof Paul O'Neill BSc Hons PhD CChem MRSC

Professor Chemistry

    Research

    Synthetic Organic Chemistry

    Research Grants

    New combination therapy against MDR TB targeting the respiratory chain

    MEDICAL RESEARCH COUNCIL (MRC)

    March 2019 - February 2022

    LSTM MRC-CiC Determining the potency of hybrid antibiotics, informed by collateral sensitivity networks, against a panel of susceptible and resistant clinical Escherichia coli isolates.

    LIVERPOOL SCHOOL OF TROPICAL MEDICINE (UK)

    October 2018 - October 2019

    Development of Small Molecule Inhibitors of the Mitochondrial Electron Transport Chain of Plasmodium falciparum

    DEPARTMENT FOR BUSINESS, ENERGY AND INDUSTRIAL STRATEGY (BEIS) (UK)

    March 2018 - March 2020

    Pre-Clinical Development of small molecule anti-Wolbachia candidate macrofilaricide drug

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2018 - February 2020

    A new generation of Crystallographic detector for Multi-user Barkla X-ray laboratory

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    July 2017 - July 2018

    Rational Design, Synthesis and Biological Evaluation of Benzimidazoles Towards a Novel Therapy Selectively Targeting C. neoformans beta-tubulin

    MEDICAL RESEARCH COUNCIL (MRC)

    July 2016 - December 2019

    Positive Allosteric Modulators of Strychnine-Sensitive Glycine Receptors – A New Concept in Treating Chronic Pain

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2012 - February 2015

    A new drug target against Malaria

    LEVERHULME TRUST (UK)

    June 2006 - May 2009

    Resistant Breaking Insecticides - Project New Pyrethroids

    BAYER CORPORATION (USA)

    December 2007 - December 2011

    Synthesis and Biomimetic Chemistry of Novel Antimalarial Endoperoxide Cysteine Protease Inhibitor (ECPI) Pro-Drugs.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    September 2000 - August 2003

    400 MHz NMR Spectrometer.

    ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL (EPSRC)

    March 2000 - February 2003

    Alternative complex 1 as a drug target in malaria

    WELLCOME TRUST (UK)

    December 2008 - September 2011

    Lead Series Development & Optimisation af a New Drug Against Active and Latent Tuberculosis.

    MEDICAL RESEARCH COUNCIL (MRC)

    October 2011 - March 2014

    Defining the mechanism of action of the 8-aminoquinolines: A pre-requisite to rationally designed safe antimalarials for the elimination era

    MEDICAL RESEARCH COUNCIL (MRC)

    August 2014 - December 2016

    University of Liverpool Institutional Discipline Bridging.

    MEDICAL RESEARCH COUNCIL (MRC)

    October 2003 - October 2006

    Quantitative high-throughput proteomics for biomedical research.

    MEDICAL RESEARCH COUNCIL (MRC)

    March 2005 - March 2008

    Synthesis and biological evaluation of primaquine metabolites: implications of safety and efficacy

    MEDICINES FOR MALARIA VENTURE (SWITZERLAND)

    July 2014 - July 2015

    Cloning and characterisation of enzymes required for the in vitro synthesis of the antimalarial artemisinin.

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2002 - August 2003

    Probing the molecular mechanism of action of novel antimalarial falcipain 2 inhibitor endoperoxide pro-drugs in isolated parasite digestive vacuoles.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    March 2005 - February 2008

    Development of New Drugs for the Treatment of Malaria (ANTIMAL)

    EUROPEAN COMMISSION

    December 2005 - May 2011

    TCAMS triazole series as potential serine protease inhibitors.

    TRES CANTOS OPEN LAB FOUNDATION (UK)

    October 2012 - September 2014

    Bridging and accelerating the translation of novel scientific findings for health and wealth gain

    MEDICAL RESEARCH COUNCIL (MRC)

    March 2014 - August 2015

    KEL09/13 - Molecular design and chemoinformatics: A combined approach to novel molecules

    ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL (EPSRC)

    December 2010 - March 2012

    Towards a 21st Century Replacement for the 4-Aminoquinoline Chloroquine

    ROYAL SOCIETY (CHARITABLE)

    July 2006

    Co(II)L2 Mediated Catalytic Aerobic Asymmetric Peroxysilylation and Hydration of Unactivated Alkenes.

    ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL (EPSRC)

    November 2000 - October 2002