2023
Stachulski, A. V., Rossignol, J. -F., Pate, S., Taujanskas, J., Iggo, J. A., Aerts, R., . . . O'Neill, P. M. (2023). Thiazolide Prodrug Esters and Derived Peptides: Synthesis and Activity.. ACS bio & med chem Au, 3(4), 327-334. doi:10.1021/acsbiomedchemau.2c00083DOI: 10.1021/acsbiomedchemau.2c00083
Hong, W. D., O'Neill, P. M., Taylor, M. J., Turner, J. D., Ward, S. A., Gusovsky, F., . . . Khile, A. S. (2023). Transformation of the Manufacturing Process from Discovery to Kilogram Scale for AWZ1066S: A Highly Specific Anti-Wolbachia Drug Candidate for a Short-Course Treatment of Filariasis. ORGANIC PROCESS RESEARCH & DEVELOPMENT. doi:10.1021/acs.oprd.2c00167DOI: 10.1021/acs.oprd.2c00167
Jeffreys, L. N., Ardrey, A., Hafiz, T. A., Dyer, L. -A., Warman, A. J., Mosallam, N., . . . Biagini, G. A. (2023). Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis. ACS INFECTIOUS DISEASES. doi:10.1021/acsinfecdis.2c00283DOI: 10.1021/acsinfecdis.2c00283
Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in <i>Plasmodium falciparum</i> (Journal article)
Lisauskaitė, M., Nixon, G. L., Woodley, C. M., Berry, N. G., Coninckx, A., Qie, L. C., . . . O'Neill, P. M. (n.d.). Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in <i>Plasmodium falciparum</i>. RSC Chemical Biology. doi:10.1039/d3cb00109aDOI: 10.1039/d3cb00109a
2022
Amado, P. S. M., Woodley, C., Cristiano, M. L. S., & O'Neill, P. M. (2022). Recent Advances of DprE1 Inhibitors against<i> Mycobacterium</i><i> tuberculosis:</i> Computational Analysis of Physicochemical and ADMET Properties. ACS OMEGA. doi:10.1021/acsomega.2c05307DOI: 10.1021/acsomega.2c05307
Abdou, M. M., Dong, D., O'Neill, P. M., Amigues, E., & Matziari, M. (2022). Design, Synthesis, and Study of a Novel RXPA380-Proline Hybrid (RXPA380-P) as an Antihypertensive Agent. ACS OMEGA, 7(39), 35035-35043. doi:10.1021/acsomega.2c03813DOI: 10.1021/acsomega.2c03813
2021
Chu, C. S. M., Simpson, J. D., O'Neill, P. M., & Berry, N. G. (2021). Machine learning-Predicting Ames mutagenicity of small molecules. JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 109. doi:10.1016/j.jmgm.2021.108011DOI: 10.1016/j.jmgm.2021.108011
Woodley, C. M., Amado, P. S. M., Cristiano, M. L. S., & O'Neill, P. M. (2021). Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies. MEDICINAL RESEARCH REVIEWS, 41(6), 3062-3095. doi:10.1002/med.21849DOI: 10.1002/med.21849
Stachulski, A. V., Rossignol, J. -F., Pate, S., Taujanskas, J., Robertson, C. M., Aerts, R., . . . O'Neill, P. M. (2021). Synthesis, antiviral activity, preliminary pharmacokinetics and structural parameters of thiazolide amine salts. FUTURE MEDICINAL CHEMISTRY, 13(20). doi:10.4155/fmc-2021-0055DOI: 10.4155/fmc-2021-0055
McGillan, P., Berry, N. G., Nixon, G. L., Leung, S. C., Webborn, P. J. H., Wenlock, M. C., . . . O’Neill, P. M. (2021). Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis. ACS Medicinal Chemistry Letters, 12(9), 1421-1426. doi:10.1021/acsmedchemlett.1c00216DOI: 10.1021/acsmedchemlett.1c00216
Amado, P. S. M., Frija, L. M. T., Coelho, J. A. S., O’Neill, P. M., & Cristiano, M. L. S. (2021). Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid. The Journal of Organic Chemistry, 86(15), 10608-10620. doi:10.1021/acs.joc.1c01258DOI: 10.1021/acs.joc.1c01258
Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid (Journal article)
Amado, P. S. M., Frija, L. M. T., Coelho, J. A. S., O'Neill, P. M., & Cristiano, M. L. S. (2021). Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid. JOURNAL OF ORGANIC CHEMISTRY, 86(15), 10608-10620. doi:10.1021/acs.joc.1c01258DOI: 10.1021/acs.joc.1c01258
Woodley, C. M., Nixon, G. L., Basilico, N., Parapini, S., Hong, W. D., Ward, S. A., . . . O'Neill, P. M. (2021). Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205. ACS MEDICINAL CHEMISTRY LETTERS, 12(7), 1077-1085. doi:10.1021/acsmedchemlett.1c00031DOI: 10.1021/acsmedchemlett.1c00031
Johnston, K. L., Hong, W. D., Turner, J. D., O'Neill, P. M., Ward, S. A., & Taylor, M. J. (2021). Anti-Wolbachia drugs for filariasis. TRENDS IN PARASITOLOGY, 37(12), 1068-1081. doi:10.1016/j.pt.2021.06.004DOI: 10.1016/j.pt.2021.06.004
Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2? (Journal article)
Stachulski, A. V., Taujanskas, J., Pate, S. L., Rajoli, R. K. R., Aljayyoussi, G., Pennington, S. H., . . . O'Neill, P. M. (2021). Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2?. ACS INFECTIOUS DISEASES, 7(6), 1317-1331. doi:10.1021/acsinfecdis.0c00478DOI: 10.1021/acsinfecdis.0c00478
Amporndanai, K., Meng, X., Shang, W., Jin, Z., Zhao, Y., Rao, Z., . . . Rogers, M. (2021). Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-23313-7DOI: 10.1038/s41467-021-23313-7
Rajoli, R. K. R., Pertinez, H., Arshad, U., Box, H., Tatham, L., Curley, P., . . . Owen, A. (2021). Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(4), 2078-2088. doi:10.1111/bcp.14619DOI: 10.1111/bcp.14619
2020
Amporndanai, K., Rogers, M., Watanabe, S., Yamanaka, K., O'Neill, P. M., & Hasnain, S. S. (2020). Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis. EBIOMEDICINE, 59. doi:10.1016/j.ebiom.2020.102980DOI: 10.1016/j.ebiom.2020.102980
Alghamdi, A. H., Munday, J. C., Campagnaro, G. D., Gurvic, D., Svensson, F., Okpara, C. E., . . . De Koning, H. P. (2020). Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter <i>Trypanosoma brucei</i>. ELIFE, 9. doi:10.7554/eLife.56416DOI: 10.7554/eLife.56416
Arshad, U., Pertinez, H., Box, H., Tatham, L., Rajoli, R. K., Curley, P., . . . Owen, A. (2020). Prioritisation of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics.. Clinical pharmacology and therapeutics. doi:10.1002/cpt.1909DOI: 10.1002/cpt.1909
Rajoli, R. K., Pertinez, H., Arshad, U., Box, H., Tatham, L., Curley, P., . . . Owen, A. (2020). Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis.. medRxiv : the preprint server for health sciences. doi:10.1101/2020.05.01.20087130DOI: 10.1101/2020.05.01.20087130
Chantadul, V., Wright, G. S. A., Amporndanai, K., Shahid, M., Antonyuk, S. V., Washbourn, G., . . . Hasnain, S. S. (2020). Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy. COMMUNICATIONS BIOLOGY, 3(1). doi:10.1038/s42003-020-0826-3DOI: 10.1038/s42003-020-0826-3
2019
Rolt, A., O'Neill, P. M., Liang, T. J., & Stachulski, A. V. (2019). Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR. RSC ADVANCES, 9(69), 40336-40339. doi:10.1039/c9ra08256eDOI: 10.1039/c9ra08256e
Camarda, G., Jirawatcharadech, P., Priestley, R. S., Saif, A., March, S., Wong, M. H. L., . . . Biagini, G. A. (2019). Antimalarial activity of primaquine operates via a two-step biochemical relay. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-019-11239-0DOI: 10.1038/s41467-019-11239-0
Panmanee, J., Bradley-Clarke, J., Mato, J. M., O'Neill, P. M., Antonyuk, S. V., & Hasnain, S. S. (2019). Control and regulation of S‐Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone‐based compounds. The Federation of European Biochemical Societies (FEBS) Journal, 286(11), 2135-2154. doi:10.1111/febs.14790DOI: 10.1111/febs.14790
Phosphinic acids: current status and potential for drug discovery (Journal article)
Abdou, M. M., O'Neill, P. M., Amigues, E., & Matziari, M. (2019). Phosphinic acids: current status and potential for drug discovery. DRUG DISCOVERY TODAY, 24(3), 916-929. doi:10.1016/j.drudis.2018.11.016DOI: 10.1016/j.drudis.2018.11.016
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis (Journal article)
Hong, W. D., Benayoud, F., Nixon, G. L., Ford, L., Johnston, K. L., Clare, R. H., . . . O'Neill, P. M. (2019). AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(4), 1414-1419. doi:10.1073/pnas.1816585116DOI: 10.1073/pnas.1816585116
Clare, R. H., Bardelle, C., Harper, P., Hong, W. D., Borjesson, U., Johnston, K. L., . . . Ward, S. A. (2019). Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-018-07826-2DOI: 10.1038/s41467-018-07826-2
A NEW RAPID ACTING ANTI-WOLBACHIA DRUG FOR ONCHOCERCIASIS AND LYMPHATIC FILARIASIS (Conference Paper)
Hong, W. D., Johnston, K. L., Berry, N. G., Gusovsky, F., Heming-Way, J., Turner, J. D., . . . O'Neill, P. M. (2019). A NEW RAPID ACTING ANTI-WOLBACHIA DRUG FOR ONCHOCERCIASIS AND LYMPHATIC FILARIASIS. In TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE Vol. 113 (pp. S4). Retrieved from https://www.webofscience.com/
2018
David Hong, W., Leung, S. C., Amporndanai, K., Davies, J., Priestley, R. S., Nixon, G. L., . . . O'Neill, P. M. (2018). Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties. ACS Medicinal Chemistry Letters, 9(12), 1205-1210. doi:10.1021/acsmedchemlett.8b00371DOI: 10.1021/acsmedchemlett.8b00371
Wong, S. Q., Pontifex, M. G., Phelan, M. M., Pidathala, C., Kraemer, B. C., Barclay, J. W., . . . Morgan, A. (2018). α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy. Neurobiology of disease, 118, 40-54. doi:10.1016/j.nbd.2018.06.013DOI: 10.1016/j.nbd.2018.06.013
Lawrenson, A. S., Cooper, D. L., O'Neill, P. M., & Berry, N. G. (2018). Study of the antimalarial activity of 4-aminoquinoline compounds against chloroquine-sensitive and chloroquine-resistant parasite strains. JOURNAL OF MOLECULAR MODELING, 24(9). doi:10.1007/s00894-018-3755-zDOI: 10.1007/s00894-018-3755-z
O' Neill, P. M., Stocks, P. A., Sabbani, S., Roberts, N. L., Amewu, R. K., Shore, E. R., . . . Ward, S. A. (2018). Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria. BIOORGANIC & MEDICINAL CHEMISTRY, 26(11), 2996-3005. doi:10.1016/j.bmc.2018.05.006DOI: 10.1016/j.bmc.2018.05.006
Capper, M. J., Wright, G. S. A., Barbieri, L., Luchinat, E., Mercatelli, E., McAlary, L., . . . Hasnain, S. S. (2018). The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-04114-xDOI: 10.1038/s41467-018-04114-x
Stachulski, A. V., Santoro, M. G., Piacentini, S., Belardo, G., La Frazia, S., Pidathala, C., . . . Rossignol, J. -F. (2018). Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus. FUTURE MEDICINAL CHEMISTRY, 10(8), 851-862. doi:10.4155/fmc-2017-0217DOI: 10.4155/fmc-2017-0217
Amporndanai, K., Johnson, R. M., O'Neill, P., Fishwick, C. W. G., Jamson, A. H., Rawson, S., . . . Hasnain, S. (2018). X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery. IUCrJ, 5(Pt 2), 200-210. doi:10.1107/S2052252518001616DOI: 10.1107/S2052252518001616
2017
Johnston, K. L., Cook, D. A. N., Berry, N. G., Hong, W. D., Clare, R. H., Goddard, M., . . . Taylor, M. J. (2017). Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library. SCIENCE ADVANCES, 3(09). doi:10.1126/sciadv.aao1551DOI: 10.1126/sciadv.aao1551
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance (Journal article)
O'Neill, P. M., Amewu, R. K., Charman, S. A., Sabbani, S., Gnädig, N. F., Straimer, J., . . . Ward, S. A. (2017). A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance. Nature Communications, 8. doi:10.1038/ncomms15159DOI: 10.1038/ncomms15159
Hong, W. D., Gibbons, P. D., Leung, S. C., Amewu, R., Stocks, P. A., Stachulski, A. V., . . . Nixon, G. L. (2017). Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis.. Journal of medicinal chemistry, 60(9), 3703-3726. doi:10.1021/acs.jmedchem.6b01718DOI: 10.1021/acs.jmedchem.6b01718
2016
Price, K. E., Armstrong, C. M., Imlay, L. S., Hodge, D. M., Pidathala, C., Roberts, N. J., . . . Odom John, A. R. (2016). Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD. Scientific Reports, 6. doi:10.1038/srep36777DOI: 10.1038/srep36777
Kesornpun, C., Aree, T., Mahidol, C., Ruchirawat, S., & Kittakoop, P. (2016). Corrigendum: Water‐Assisted Nitrile Oxide Cycloadditions: Synthesis of Isoxazoles and Stereoselective Syntheses of Isoxazolines and 1,2,4‐Oxadiazoles. Angewandte Chemie International Edition, 55(36), 10548. doi:10.1002/anie.201607026DOI: 10.1002/anie.201607026
Fernandez-Alvaro, E., Hong, W. D., Nixon, G. L., O'Neil, P. M., & Calderon, F. (2016). Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action. JOURNAL OF MEDICINAL CHEMISTRY, 59(12), 5587-5603. doi:10.1021/acs.jmedchem.5b01485DOI: 10.1021/acs.jmedchem.5b01485
Ismail, H. M., Barton, V. E., Panchana, M., Charoensutthivarakul, S., Biagini, G. A., Ward, S. A., & O'Neill, P. M. (2016). A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 55(22), 6401-6405. doi:10.1002/anie.201512062DOI: 10.1002/anie.201512062
Ismail, H. M., Barton, V. E., Panchana, M., Charoensutthivarakul, S., Biagini, G. A., Ward, S. A., & O'Neill, P. M. (2016). A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.. Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 128(22), 6511-6515. doi:10.1002/ange.201512062DOI: 10.1002/ange.201512062
Wong, M. H. L., Bryan, H. K., Copple, I. M., Jenkins, R. E., Chiu, P. H., Bibby, J., . . . Park, B. K. (2016). Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites. JOURNAL OF MEDICINAL CHEMISTRY, 59(6), 2396-2409. doi:10.1021/acs.jmedchem.5b01292DOI: 10.1021/acs.jmedchem.5b01292
Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis (Journal article)
Shore, E. R., Awais, M., Kershaw, N. M., Gibson, R. R., Pandalanen, S., Latawiec, D., . . . Sutton, R. (2016). Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis. JOURNAL OF MEDICINAL CHEMISTRY, 59(06), 2596-2611. doi:10.1021/acs.jmedchem.5b01801DOI: 10.1021/acs.jmedchem.5b01801
Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7 (Journal article)
Ismail, H. M., Barton, V., Phanchana, M., Charoensutthivarakul, S., Wong, M. H. L., Hemingway, J., . . . Ward, S. A. (2016). Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(8), 2080-2085. doi:10.1073/pnas.1600459113DOI: 10.1073/pnas.1600459113
2015
Quinolone-Hydroxyquinoline Tautomerism in Quinolone 3-Esters. Preserving the 4-Oxoquinoline Structure To Retain Antimalarial Activity (Journal article)
Horta, P., Kus, N., Henriques, M. S. C., Paixao, J. A., Coelho, L., Nogueira, F., . . . Santos Cristiano, M. L. (2015). Quinolone-Hydroxyquinoline Tautomerism in Quinolone 3-Esters. Preserving the 4-Oxoquinoline Structure To Retain Antimalarial Activity. JOURNAL OF ORGANIC CHEMISTRY, 80(24), 12244-12257. doi:10.1021/acs.joc.5b02169DOI: 10.1021/acs.joc.5b02169
Shelton, L. M., Lister, A., Walsh, J., Jenkins, R. E., Wong, M. H. L., Rowe, C., . . . Copple, I. M. (2015). Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney. KIDNEY INTERNATIONAL, 88(06), 1261-1273. doi:10.1038/ki.2015.286DOI: 10.1038/ki.2015.286
Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation (Journal article)
Naisbitt, D., Yang, E. L., Alhaidari, M., Berry, N., Lawrenson, A. S., Farrell, J., . . . Park, B. (2015). Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation. AIDS, 29(18), 2385-2395. doi:10.1097/QAD.0000000000000867DOI: 10.1097/QAD.0000000000000867
A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle (Journal article)
O'Neill, P. M., & Ward, S. A. (2015). A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54(46), 13504-13506. doi:10.1002/anie.201507264DOI: 10.1002/anie.201507264
Synthesis, structural and conformational analysis, and IR spectra of ethyl 4-chloro-7-iodoquinoline-3-carboxylate (Journal article)
Horta, P. C., Henriques, M. S. C., Kus, N., Paixao, J. A., O'Neill, P. M., Cristiano, M. L. S., & Fausto, R. (2015). Synthesis, structural and conformational analysis, and IR spectra of ethyl 4-chloro-7-iodoquinoline-3-carboxylate. TETRAHEDRON, 71(40), 7583-7592. doi:10.1016/j.tet.2015.07.076DOI: 10.1016/j.tet.2015.07.076
Carbamoyl triazoles, Known Serine Protease Inhibitors, are a potent New Class of Antimalarial (Journal article)
O'Neill, P., McConville, M., Fernandez-molina, J., Angulo-Barturen, I., Bahamontes, N. R., Ballell-Pages, L., . . . Calderon, F. (2015). Carbamoyl triazoles, Known Serine Protease Inhibitors, are a potent New Class of Antimalarial. Journal of Medicinal Chemistry, 58(16), 6448-6455. doi:10.1021/acs.jmedchem.5b00434DOI: 10.1021/acs.jmedchem.5b00434
From hybrid compounds to targeted drug delivery in antimalarial therapy (Journal article)
Oliveira, R., Miranda, D., Magalhaes, J., Capela, R., Perry, M. J., O'Neill, P. M., . . . Lopes, F. (2015). From hybrid compounds to targeted drug delivery in antimalarial therapy. BIOORGANIC & MEDICINAL CHEMISTRY, 23(16), 5120-5130. doi:10.1016/j.bmc.2015.04.017DOI: 10.1016/j.bmc.2015.04.017
2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties (Journal article)
Charoensutthivarakul, S., Hong, W. D., Leung, S. C., Gibbons, P. D., Bedingfield, P. T. P., Nixon, G. L., . . . O'Neill, P. M. (2015). 2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties. MEDCHEMCOMM, 6(7), 1252-1259. doi:10.1039/c5md00062aDOI: 10.1039/c5md00062a
<i>Plasmodium</i> IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target (Journal article)
Imlay, L. S., Armstrong, C. M., Masters, M. C., Li, T., Price, K. E., Edwards, R. L., . . . Odom, A. R. (2015). <i>Plasmodium</i> IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target. ACS INFECTIOUS DISEASES, 1(4), 157-167. doi:10.1021/id500047sDOI: 10.1021/id500047s
Inhibitors of the Plasmodium Mitochondrial Respiratory Chain (Chapter)
Nixon, G. L., Ward, S. A., O’Neill, P. M., & Biagini, G. A. (2014). Inhibitors of the Plasmodium Mitochondrial Respiratory Chain. In Encyclopedia of Malaria (pp. 1-18). Springer New York. doi:10.1007/978-1-4614-8757-9_15-1DOI: 10.1007/978-1-4614-8757-9_15-1
Capper, M., O'Neill, P., Fisher, N., Strange, R., Moss, D., Ward, S., . . . Antonyuk, S. (2015). Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1. Proceedings of the National Academy of Sciences of the United States of America, 112(3), 755-760. doi:10.1073/pnas.1416611112DOI: 10.1073/pnas.1416611112
2014
Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications (Journal article)
Walsh, J., Jenkins, R. E., Wong, M., Olayanju, A., Powell, H., Copple, I., . . . Park, B. K. (2014). Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications. JOURNAL OF PROTEOMICS, 108, 171-187. doi:10.1016/j.jprot.2014.05.007DOI: 10.1016/j.jprot.2014.05.007
Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials. (Journal article)
Oliveira, R., Guedes, R. C., Meireles, P., Albuquerque, I. S., Gonçalves, L. M., Pires, E., . . . Lopes, F. (2014). Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials.. Journal of medicinal chemistry, 57(11), 4916-4923. doi:10.1021/jm5004528DOI: 10.1021/jm5004528
Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities (Journal article)
Miranda, D., Capela, R., Albuquerque, I. S., Meireles, P., Paiva, I., Nogueira, F., . . . Lopes, F. (2014). Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities. ACS MEDICINAL CHEMISTRY LETTERS, 5(2), 108-112. doi:10.1021/ml4002985DOI: 10.1021/ml4002985
4-bromopropofol decreases action potential generation in spinal neurons by inducing a glycine receptor-mediated tonic conductance (Journal article)
Eckle, V. S., Grasshoff, C., Mirakaj, V., O'Neill, P. M., Berry, N. G., Leuwer, M., & Antkowiak, B. (2014). 4-bromopropofol decreases action potential generation in spinal neurons by inducing a glycine receptor-mediated tonic conductance. BRITISH JOURNAL OF PHARMACOLOGY, 171(24), 5790-5801. doi:10.1111/bph.12880DOI: 10.1111/bph.12880
Novel inhibitors of the Plasmodium falciparum electron transport chain (Journal article)
Stocks, P. A., Barton, V., Antoine, T., Biagini, G. A., Ward, S. A., & O'Neill, P. M. (2014). Novel inhibitors of the Plasmodium falciparum electron transport chain. PARASITOLOGY, 141(1), 50-65. doi:10.1017/S0031182013001571DOI: 10.1017/S0031182013001571
Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential (Journal article)
Antoine, T., Fisher, N., Amewu, R., ONeill, P. M., Ward, S. A., & Biagini, G. A. (2014). Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 69(4), 1005-1016. doi:10.1093/jac/dkt486DOI: 10.1093/jac/dkt486
2013
Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles. (Journal article)
Elliott, E. -C., Maggs, J. L., Park, B. K., O'Neill, P. M., & Stachulski, A. V. (2013). Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles.. Organic & biomolecular chemistry, 11(48), 8426-8434. doi:10.1039/c3ob41252kDOI: 10.1039/c3ob41252k
Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions (Journal article)
Ismail, H. M., O'Neill, P. M., Hong, D. W., Finn, R. D., Henderson, C. J., Wright, A. T., . . . Paine, M. J. I. (2013). Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(49), 19766-19771. doi:10.1073/pnas.1320185110DOI: 10.1073/pnas.1320185110
Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers (Journal article)
Amewu, R. K., Chadwick, J., Hussain, A., Panda, S., Rinki, R., Janneh, O., . . . O'Neill, P. M. (2013). Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers. BIOORGANIC & MEDICINAL CHEMISTRY, 21(23), 7392-7397. doi:10.1016/j.bmc.2013.09.047DOI: 10.1016/j.bmc.2013.09.047
An Endoperoxide-Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites (Journal article)
Oliveira, R., Newton, A. S., Guedes, R. C., Miranda, D., Amewu, R. K., Srivastava, A., . . . Moreira, R. (2013). An Endoperoxide-Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites. CHEMMEDCHEM, 8(9), 1528-1536. doi:10.1002/cmdc.201300202DOI: 10.1002/cmdc.201300202
Nixon, G. L., Pidathala, C., Shone, A. E., Antoine, T., Fisher, N., O'Neill, P. M., . . . Biagini, G. A. (2013). Targeting the mitochondrial electron transport chain of <i>Plasmodium falciparum</i>: new strategies towards the development of improved antimalarials for the elimination era. FUTURE MEDICINAL CHEMISTRY, 5(13), 1573-1591. doi:10.4155/fmc.13.180DOI: 10.4155/fmc.13.180
Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells (Journal article)
Bell, C. C., Castelazo, A. S., Yang, E. L., Maggs, J. L., Jeankins, R. E., Tugwood, J., . . . Park, B. K. (2013). Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells. CHEMICAL RESEARCH IN TOXICOLOGY, 26(7), 1064-1072. doi:10.1021/tx400041vDOI: 10.1021/tx400041v
Antimalarial pharmacology and therapeutics of atovaquone (Journal article)
Nixon, G. L., Moss, D. M., Shone, A. E., Lalloo, D. G., Fisher, N., O'Neill, P. M., . . . Biagini, G. A. (2013). Antimalarial pharmacology and therapeutics of atovaquone. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 68(5), 977-985. doi:10.1093/jac/dks504DOI: 10.1093/jac/dks504
Nixon, G. L., Moss, D. M., Shone, A. E., Lalloo, D. G., Fisher, N., O'Neill, P. M., . . . Biagini, G. A. (2013). Antimalarial pharmacology and therapeutics of atovaquone. Journal of Antimicrobial Chemotherapy, 68(5), 977-985. doi:10.1093/jac/dks504DOI: 10.1093/jac/dks504
Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation (Journal article)
La Pensee, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A. E., . . . O'Neill, P. M. (2013). Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation. CHEMMEDCHEM, 8(5), 709-718. doi:10.1002/cmdc.201200536DOI: 10.1002/cmdc.201200536
Antitubercular pharmacodynamics of phenothiazines (Journal article)
Warman, A. J., Rito, T. S., Fisher, N. E., Moss, D. M., Berry, N. G., O'Neill, P. M., . . . Biagini, G. A. (2013). Antitubercular pharmacodynamics of phenothiazines. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 68(4), 869-880. doi:10.1093/jac/dks483DOI: 10.1093/jac/dks483
Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation (Journal article)
La Pensée, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A. E., . . . O'Neill, P. M. (2013). Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation. ChemMedChem, 8(5), 709-718.
X-ray Crystallography and Computational Docking for the Detection and Development of Protein-Ligand Interactions (Journal article)
Kershaw, N. M., Wright, G. S. A., Sharma, R., Antonyuk, S. V., Strange, R. W., Berry, N. G., . . . Hasnain, S. S. (2013). X-ray Crystallography and Computational Docking for the Detection and Development of Protein-Ligand Interactions. CURRENT MEDICINAL CHEMISTRY, 20(4), 569-575. Retrieved from https://www.webofscience.com/
2012
Copple, I. M., Mercer, A. E., Firman, J., Donegan, G., Herpers, B., Wong, M. H. L., . . . Park, B. K. (2012). Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials. MOLECULAR MEDICINE, 18(7), 1045-1055. doi:10.2119/molmed.2012.00154DOI: 10.2119/molmed.2012.00154
HDQ, a Potent Inhibitor of <i>Plasmodium falciparum</i> Proliferation, Binds to the Quinone Reduction Site of the Cytochrome <i>bc</i><sub>1</sub> Complex (Journal article)
Vallieres, C., Fisher, N., Antoine, T., Al-Helal, M., Stocks, P., Berry, N. G., . . . Meunier, B. (2012). HDQ, a Potent Inhibitor of <i>Plasmodium falciparum</i> Proliferation, Binds to the Quinone Reduction Site of the Cytochrome <i>bc</i><sub>1</sub> Complex. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56(7), 3739-3747. doi:10.1128/AAC.00486-12DOI: 10.1128/AAC.00486-12
Generation of quinolone antimalarials targeting the <i>Plasmodium falciparum</i> mitochondrial respiratory chain for the treatment and prophylaxis of malaria (Journal article)
Biagini, G. A., Fisher, N., Shone, A. E., Mubaraki, M. A., Srivastava, A., Hill, A., . . . Ward, S. A. (2012). Generation of quinolone antimalarials targeting the <i>Plasmodium falciparum</i> mitochondrial respiratory chain for the treatment and prophylaxis of malaria. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(21), 8298-8303. doi:10.1073/pnas.1205651109DOI: 10.1073/pnas.1205651109
Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods (Journal article)
Sharma, R., Lawrenson, A. S., Fisher, N. E., Warman, A. J., Shone, A. E., Hill, A., . . . Berry, N. G. (2012). Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods. JOURNAL OF MEDICINAL CHEMISTRY, 55(7), 3144-3154. doi:10.1021/jm3001482DOI: 10.1021/jm3001482
The MEP pathway and the development of inhibitors as potential anti-infective agents (Journal article)
Hale, I., O'Neill, P. M., Berry, N. G., Odom, A., & Sharma, R. (2012). The MEP pathway and the development of inhibitors as potential anti-infective agents. MEDCHEMCOMM, 3(4), 418-433. doi:10.1039/c2md00298aDOI: 10.1039/c2md00298a
Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2) (Journal article)
Pidathala, C., Amewu, R., Pacorel, B., Nixon, G. L., Gibbons, P., Hong, W. D., . . . O'Neill, P. M. (2012). Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2). JOURNAL OF MEDICINAL CHEMISTRY, 55(5), 1831-1843. doi:10.1021/jm201179hDOI: 10.1021/jm201179h
Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2) (Journal article)
Leung, S. C., Gibbons, P., Amewu, R., Nixon, G. L., Pidathala, C., Hong, W. D., . . . O'Neill, P. M. (2012). Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2). JOURNAL OF MEDICINAL CHEMISTRY, 55(5), 1844-1857. doi:10.1021/jm201184hDOI: 10.1021/jm201184h
Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc(1) Catalytic Turnover and Protein Expression (Journal article)
Fisher,, N., Majid,, R. A., Antoine,, T., Al-Helal,, M., Warman,, A. J., Johnson,, D. J., . . . Biagini,, G. A. (2012). Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc(1) Catalytic Turnover and Protein Expression. Journal of Biological Chemistry, 287, 9731-9741.
Examination of the Cytotoxic and Embryotoxic Potential, and Underlying Mechanisms, of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials (Journal article)
Copple, I., Chadwick, A., Firman, J., Donegan, G., Herpers, B., Wong, M. H. L., . . . Park, K. (2012). Examination of the Cytotoxic and Embryotoxic Potential, and Underlying Mechanisms, of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials. Molecular Medicine, 18, 1045-1055.
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain (Journal article)
Shone, A. E., Fisher, N., Mubaraki, M. A., Srivastava, A., Hill, A., Antoine, T., . . . Berry, N. (2012). Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain. Proceedings of the National Academy of Sciences of the United States of America, (109), 8298-8303.
HDQ, A Potent Inhibitor Of Plasmodium Falciparum Proliferation Binds To The Qi Site Of The Bc1 Complex (Journal article)
Vallières, C., Fisher, N., Antoine, T., Al-Helal, M., Stocks, P., Berry, N. G., . . . Meunier, B. (2012). HDQ, A Potent Inhibitor Of Plasmodium Falciparum Proliferation Binds To The Qi Site Of The Bc1 Complex. Antimicrobial Agents and Chemotherapy, 56, 3739-3747.
HDQ, a Potent Inhibitor of Plasmodium falciparum Proliferation, Binds to the Quinone Reduction Site of the Cytochrome bc(1) Complex (Journal article)
Vallieres,, C., Fisher,, N., Antoine,, T., Al-Helal,, M., Stocks,, P., Berry,, N. G., . . . Meunier,, B. (2012). HDQ, a Potent Inhibitor of Plasmodium falciparum Proliferation, Binds to the Quinone Reduction Site of the Cytochrome bc(1) Complex. Antimicrobial Agents and Chemotherapy, 56, 3739-3747.
The development of quinolone esters as novel antimalarial agents targeting the <i>Plasmodium falciparum bc</i><sub>1</sub> protein complex (Journal article)
Cowley, R., Leung, S., Fisher, N., Al-Helal, M., Berry, N. G., Lawrenson, A. S., . . . O'Neill, P. M. (2012). The development of quinolone esters as novel antimalarial agents targeting the <i>Plasmodium falciparum bc</i><sub>1</sub> protein complex. MEDCHEMCOMM, 3(1), 39-44. doi:10.1039/c1md00183cDOI: 10.1039/c1md00183c
2011
Convenient syntheses of benzo-fluorinated dibenz[b,f]azepines: rearrangements of isatins, acridines, and indoles. (Journal article)
Elliott, E. -C., Bowkett, E. R., Maggs, J. L., Bacsa, J., Park, B. K., Regan, S. L., . . . Stachulski, A. V. (2011). Convenient syntheses of benzo-fluorinated dibenz[b,f]azepines: rearrangements of isatins, acridines, and indoles.. Organic letters, 13(20), 5592-5595. doi:10.1021/ol202318wDOI: 10.1021/ol202318w
Comparison of the Reactivity of Antimalarial 1,2,4,5-Tetraoxanes with 1,2,4-Trioxolanes in the Presence of Ferrous Iron Salts, Heme, and Ferrous Iron Salts/Phosphatidylcholine (Journal article)
Bousejra-El Garah, F., Wong, M. H. -L., Amewu, R. K., Muangnoicharoen, S., Maggs, J. L., Stigliani, J. -L., . . . O'Neill, P. M. (2011). Comparison of the Reactivity of Antimalarial 1,2,4,5-Tetraoxanes with 1,2,4-Trioxolanes in the Presence of Ferrous Iron Salts, Heme, and Ferrous Iron Salts/Phosphatidylcholine. JOURNAL OF MEDICINAL CHEMISTRY, 54(19), 6443-6455. doi:10.1021/jm200768hDOI: 10.1021/jm200768h
Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action (Journal article)
Chadwick, J., Amewu, R. K., Marti, F., Bousejra-El Garah, F., Sharma, R., Berry, N. G., . . . O'Neill, P. M. (2011). Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action. CHEMMEDCHEM, 6(8), 1357-1361. doi:10.1002/cmdc.201100196DOI: 10.1002/cmdc.201100196
Cytochrome P450 6M2 from the malaria vector <i>Anopheles gambiae</i> metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed (Journal article)
Stevenson, B. J., Bibby, J., Pignatelli, P., Muangnoicharoen, S., O'Neill, P. M., Lian, L. -Y., . . . Paine, M. J. I. (2011). Cytochrome P450 6M2 from the malaria vector <i>Anopheles gambiae</i> metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 41(7), 492-502. doi:10.1016/j.ibmb.2011.02.003DOI: 10.1016/j.ibmb.2011.02.003
Second generation analogues of RKA182: synthetic tetraoxanes with outstanding <i>in vitro</i> and <i>in vivo</i> antimalarial activities (Journal article)
Marti, F., Chadwick, J., Amewu, R. K., Burrell-Saward, H., Srivastava, A., Ward, S. A., . . . O'Neill, P. M. (2011). Second generation analogues of RKA182: synthetic tetraoxanes with outstanding <i>in vitro</i> and <i>in vivo</i> antimalarial activities. MEDCHEMCOMM, 2(7), 661-665. doi:10.1039/c1md00102gDOI: 10.1039/c1md00102g
The Effect of Fluorine Substitution on the Physicochemical Properties and the Analgesic Activity of Paracetamol (Journal article)
Barnard, S., Storr, R. C., O’Neill, P. M., & Park, B. K. (2011). The Effect of Fluorine Substitution on the Physicochemical Properties and the Analgesic Activity of Paracetamol. Journal of Pharmacy and Pharmacology, 45(8), 736-744. doi:10.1111/j.2042-7158.1993.tb07099.xDOI: 10.1111/j.2042-7158.1993.tb07099.x
The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials (Journal article)
Mercer, A. E., Copple, I. M., Maggs, J. L., O'Neill, P. M., & Park, B. K. (2011). The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(2), 987-996. doi:10.1074/jbc.M110.144188DOI: 10.1074/jbc.M110.144188
Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action (Journal article)
Chadwick, J., Amewu, R. K., Marti, F., Bousejra-El Garah, F., Sharma, R., Berry, N. G., . . . O'Neill, P. M. (2011). Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action. Chemmedchem, 6, 1357-1361.
Convenient Syntheses of Benzo-Fluorinated Dibenz[b,f]azepines: Rearrangements of Isatins, Acridines, and Indoles (Journal article)
Elliott, E. C., Bowkett, E. R., Maggs, J. L., Bacsa, J., Park, B. K., Regan, S. L., . . . Stachulski, A. V. (2011). Convenient Syntheses of Benzo-Fluorinated Dibenz[b,f]azepines: Rearrangements of Isatins, Acridines, and Indoles. Organic Letters, 13, 5592-5595.
Identification of new antimalarial leads by use of virtual screening against cytochrome bc(1) (Journal article)
Rodrigues, T., Moreira, R., Gut, J., Rosenthal, P. J., O'Neill, P. M., Biagini, G. A., . . . Guedes, R. C. (2011). Identification of new antimalarial leads by use of virtual screening against cytochrome bc(1). Bioorganic & Medicinal Chemistry, 19, 6302-6308.
Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities (Journal article)
Marti,, F., Chadwick,, J., Amewu,, R. K., Burrell-Saward,, H., Srivastava,, A., Ward,, S. A., . . . O'Neill,, P. M. (2011). Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities. Medchemcomm, 2(661-66).
Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues (Journal article)
Berger, O., Kaniti, A., van Ba, C. T., Vial, H., Ward, S. A., Biagini, G. A., . . . O'Neill, P. M. (2011). Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues. Chemmedchem, 6, 2094-2108.
The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials (Journal article)
Mercer, A. E., Copple, I. M., Maggs, J. L., O'Neill, P. M., & Park, B. K. (2011). The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials. Journal of Biological Chemistry, 286, 987-996.
2010
Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity (Journal article)
Gibbons, P., Verissimo, E., Araujo, N. C., Barton, V., Nixon, G. L., Amewu, R. K., . . . O'Neill, P. M. (2010). Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity. JOURNAL OF MEDICINAL CHEMISTRY, 53(22), 8202-8206. doi:10.1021/jm1009567DOI: 10.1021/jm1009567
Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins (Journal article)
O'Neill, P. M., Amewu, R. K., Nixon, G. L., ElGarah, F. B., Mungthin, M., Chadwick, J., . . . Ward, S. A. (2010). Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 49(33), 5693-5697. doi:10.1002/anie.201001026DOI: 10.1002/anie.201001026
A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of <i>Plasmodium falciparum</i> (Journal article)
Fisher, N., Hill, A., Mbekeani, A., Shone, A., Nixon, G., Stocks, P., . . . Biagini, G. A. (2010). A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of <i>Plasmodium falciparum</i>. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1797, 80. doi:10.1016/j.bbabio.2010.04.241DOI: 10.1016/j.bbabio.2010.04.241
Rationale design of biotinylated antimalarial endoperoxide carbon centered radical prodrugs for applications in proteomics. (Journal article)
Barton, V., Ward, S. A., Chadwick, J., Hill, A., & O'Neill, P. M. (2010). Rationale design of biotinylated antimalarial endoperoxide carbon centered radical prodrugs for applications in proteomics.. Journal of medicinal chemistry, 53(11), 4555-4559. doi:10.1021/jm100201jDOI: 10.1021/jm100201j
Synthesis, <i>in vitro</i> and <i>in vivo</i> antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared <i>via</i> thiol-olefin co-oxygenation (TOCO) of allylic alcohols (Journal article)
Amewu, R., Gibbons, P., Mukhtar, A., Stachulski, A. V., Ward, S. A., Hall, C., . . . O'Neill, P. M. (2010). Synthesis, <i>in vitro</i> and <i>in vivo</i> antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared <i>via</i> thiol-olefin co-oxygenation (TOCO) of allylic alcohols. ORGANIC & BIOMOLECULAR CHEMISTRY, 8(9), 2068-2077. doi:10.1039/b924319dDOI: 10.1039/b924319d
Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in <i>Plasmodium falciparum</i> and HL-60 cancer cell lines (Journal article)
Chadwick, J., Jones, M., Mercer, A. E., Stocks, P. A., Ward, S. A., Park, B. K., & O'Neill, P. M. (2010). Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in <i>Plasmodium falciparum</i> and HL-60 cancer cell lines. BIOORGANIC & MEDICINAL CHEMISTRY, 18(7), 2586-2597. doi:10.1016/j.bmc.2010.02.035DOI: 10.1016/j.bmc.2010.02.035
Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin. (Journal article)
Pacorel, B., Leung, S. C., Stachulski, A. V., Davies, J., Vivas, L., Lander, H., . . . O'Neill, P. M. (2010). Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.. Journal of medicinal chemistry, 53(2), 633-640. doi:10.1021/jm901216vDOI: 10.1021/jm901216v
Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives (Journal article)
Castrejon, J. L., Lavergne, S. N., El-Sheikh, A., Farrell, J., Maggs, J. L., Sabbani, S., . . . Naisbitt, D. J. (2010). Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives. CHEMICAL RESEARCH IN TOXICOLOGY, 23(1), 184-192. doi:10.1021/tx900329bDOI: 10.1021/tx900329b
A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum (Journal article)
Fisher, N., Hill, A., Mbekeani, A., Shone, A., Nixon, G., Stocks, P., . . . Biagini, G. A. (2010). A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum. Biochimica Et Biophysica Acta-Bioenergetics, 1797, 80.
Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH:quinone oxidoreductase (Journal article)
Biagini, G. A., Hill, A., Mbekeani, A., Shone, A., Nixon, G., Stocks, P., . . . Ward, S. A. (2010). Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH:quinone oxidoreductase. Malaria journal, 9(Suppl 2), O4. doi:10.1186/1475-2875-9-s2-o4DOI: 10.1186/1475-2875-9-s2-o4
Diastereoselective schenck ene reaction of singlet oxygen with chiral allylic alcohols; access to enantiomerically enriched 1,2,4-trioxanes (Journal article)
Sabbani, S., La Pensee, L., Bacsa, J., Hedenstrom, E., & O'Neill, P. M. (2010). Diastereoselective schenck ene reaction of singlet oxygen with chiral allylic alcohols; access to enantiomerically enriched 1,2,4-trioxanes. Tetrahedron, 65, 8531-8537.
Inhibiting Plasmodium cytochrome bc(1): a complex issue (Journal article)
Barton, V., Fisher, N., Biagini, G. A., Ward, S. A., & O'Neill, P. M. (2010). Inhibiting Plasmodium cytochrome bc(1): a complex issue. Current Opinion in Chemical Biology, 14, 440-446.
Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates (Journal article)
Araujo, N. C. P., Barton, V., Jones, M., Stocks, P. A., Ward, S. A., Davies, J., . . . O'Neill, P. M. (2010). Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates. Bioorganic & Medicinal Chemistry Letters, 19, 2038.
Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols (Journal article)
Amewu, R., Gibbons, P., Mukhtar, A., Stachulski, A. V., Ward, S. A., Hall, C., . . . O'Neill, P. M. (2010). Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols. Organic & Biomolecular Chemistry, 8, 2068-2077.
The Molecular Mechanism of Action of Artemisinin-The Debate Continues (Journal article)
O'Neill, P. M., Barton, V. E., & Ward, S. A. (2010). The Molecular Mechanism of Action of Artemisinin-The Debate Continues. Molecules, 15, 1705-1721.
The type II NADH: Quinone oxidoreductase of Mycobacterium tuberculosis: A novel drug target for an age-old problem (Journal article)
Warman, A. J., Rito, T., Fisher, N., Berry, N. G., O'Neill, P. M., Ward, S. A., & Biagini, G. A. (2010). The type II NADH: Quinone oxidoreductase of Mycobacterium tuberculosis: A novel drug target for an age-old problem. Biochimica Et Biophysica Acta-Bioenergetics, 1797, 117-118.
2009
Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4′-Fluoro and 4′-Chloro Analogues of Amodiaquine. Identification of a Suitable "Back-Up" Compound for <i>N-tert</i>-Butyl Isoquine (Journal article)
O'Neill, P. M., Shone, A. E., Stanford, D., Nixon, G., Asadollahy, E., Park, B. K., . . . Ward, S. A. (2009). Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4′-Fluoro and 4′-Chloro Analogues of Amodiaquine. Identification of a Suitable "Back-Up" Compound for <i>N-tert</i>-Butyl Isoquine. JOURNAL OF MEDICINAL CHEMISTRY, 52(7), 1828-1844. doi:10.1021/jm8012757DOI: 10.1021/jm8012757
Antitumour and antimalarial activity of artemisinin-acridine hybrids (Journal article)
Jones, M., Mercer, A. E., Stocks, P. A., La Pensee, L. J. I., Cosstick, R., Park, B. K., . . . O'Neill, P. M. (2009). Antitumour and antimalarial activity of artemisinin-acridine hybrids. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(7), 2033-2037. doi:10.1016/j.bmcl.2009.02.028DOI: 10.1016/j.bmcl.2009.02.028
Antitumour and antimalarial activity of artemisinin–acridine hybrids (Journal article)
Jones, M., Mercer, A. E., Stocks, P. A., La Pensée, L. J. I., Cosstick, R., Park, B. K., . . . O’Neill, P. M. (2009). Antitumour and antimalarial activity of artemisinin–acridine hybrids. Bioorganic & Medicinal Chemistry Letters, 19(7), 2033-2037. doi:10.1016/j.bmcl.2009.02.028DOI: 10.1016/j.bmcl.2009.02.028
Candidate Selection and Preclinical Evaluation of <i>N</i>-<i>tert</i>-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century (Journal article)
O'Neill, P. M., Park, B. K., Shone, A. E., Maggs, J. L., Roberts, P., Stocks, P. A., . . . Ward, S. A. (2009). Candidate Selection and Preclinical Evaluation of <i>N</i>-<i>tert</i>-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century. JOURNAL OF MEDICINAL CHEMISTRY, 52(5), 1408-1415. doi:10.1021/jm8012618DOI: 10.1021/jm8012618
Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against <i>P-falciparum</i> malaria parasites and HL-60 cancer cells (Journal article)
Chadwick, J., Mercer, A. E., Park, B. K., Cosstick, R., & O'Neill, P. M. (2009). Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against <i>P-falciparum</i> malaria parasites and HL-60 cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY, 17(3), 1325-1338. doi:10.1016/j.bmc.2008.12.017DOI: 10.1016/j.bmc.2008.12.017
Antitumour and antimalarial activity of artemisinin-acridine hybrids (Journal article)
Jones, M., Mercer, A. E., Stocks, P. A., La Pensee, L. J., Cosstick, R., Park, B. K., . . . O'Neill, P. M. (2009). Antitumour and antimalarial activity of artemisinin-acridine hybrids. Bioorganic & Medicinal Chemistry Letters, 19, 2033-2037.
Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials (Journal article)
Davis, C. B., Bambal, R., Moorthy, G. S., Hugger, E., Xiang, H., Park, B. K., . . . Ward, S. A. (2009). Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials. Journal of Pharmaceutical Sciences, 98(1), 362-377. doi:10.1002/jps.21469DOI: 10.1002/jps.21469
Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P-falciparum malaria parasites and HL-60 cancer cells (Journal article)
Chadwick, J., Mercer, A. E., Park, B. K., Cosstick, R., & O'Neill, P. M. (2009). Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P-falciparum malaria parasites and HL-60 cancer cells. Bioorganic & Medicinal Chemistry, 17, 1325-1338.
2008
Piperidine dispiro-1,2,4-trioxane analogues (Journal article)
Sabbani, S., Stocks, P. A., Ellis, G. L., Davies, J., Hedenstrom, E., Ward, S. A., & O'Neill, P. M. (2008). Piperidine dispiro-1,2,4-trioxane analogues. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(21), 5804-5808. doi:10.1016/j.bmcl.2008.09.052DOI: 10.1016/j.bmcl.2008.09.052
Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors (Journal article)
Verissimo, E., Berry, N., Gibbons, P., Cristiano, M. L. S., Rosenthal, P. J., Gut, J., . . . O'Neill, P. M. (2008). Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(14), 4210-4214. doi:10.1016/j.bmcl.2008.05.068DOI: 10.1016/j.bmcl.2008.05.068
Stimulation of nitroso sulfamethoxazole-specific T-cells with structurally-related hydroxylamine and nitroso metabolites (Journal article)
Castrejon, J. L., Farrell, J., O'neill, P. M., Park, B. K., & Naisbitt, D. J. (2008). Stimulation of nitroso sulfamethoxazole-specific T-cells with structurally-related hydroxylamine and nitroso metabolites. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 65(6), 997. Retrieved from https://www.webofscience.com/
Acridinediones:: Selective and potent inhibitors of the malaria parasite mitochondrial <i>bc</i><sub>1</sub> complex (Journal article)
Biagini, G. A., Fisher, N., Berry, N., Stocks, P. A., Meunier, B., Williams, D. P., . . . Ward, S. A. (2008). Acridinediones:: Selective and potent inhibitors of the malaria parasite mitochondrial <i>bc</i><sub>1</sub> complex. MOLECULAR PHARMACOLOGY, 73(5), 1347-1355. doi:10.1124/mol.108.045120DOI: 10.1124/mol.108.045120
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles (Journal article)
Ellis, G. L., Amewu, R., Sabbani, S., Stocks, P. A., Shone, A., Stanford, D., . . . O'Neill, P. M. (2008). Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles. JOURNAL OF MEDICINAL CHEMISTRY, 51(7), 2170-2177. doi:10.1021/jm701435hDOI: 10.1021/jm701435h
An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity (Journal article)
Ellis, G. L., Amewu, R., Hall, C., Rimmer, K., Ward, S. A., & O’Neill, P. M. (2008). An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity. Bioorganic & Medicinal Chemistry Letters, 18(5), 1720-1724. doi:10.1016/j.bmcl.2008.01.053DOI: 10.1016/j.bmcl.2008.01.053
An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity (Journal article)
Ellis, G. L., Amewu, R., Hall, C., Rimmer, K., Ward, S. A., & O'Neill, P. M. (2008). An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(5), 1720-1724. doi:10.1016/j.bmcl.2008.01.053DOI: 10.1016/j.bmcl.2008.01.053
Piperidine dispiro-1,2,4-trioxane analogues (Journal article)
Sabbani, S., Stocks, P. A., Ellis, G. L., Davies, J., Hedenstrom, E., Ward, S. A., & O'Neill, P. M. (2008). Piperidine dispiro-1,2,4-trioxane analogues. Bioorganic & Medicinal Chemistry Letters, 18, 5804-5808.
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles (Journal article)
Ellis, G. L., Amewu, R., Sabbani, S., Stocks, P. A., Shone, A., Stanford, D., . . . O'Neill, P. M. (2008). Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles. Journal of Medicinal Chemistry, 51, 2170-2177.
2007
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs (Journal article)
Stocks, P. A., Bray, P. G., Barton, V. E., Al-Helal, M., Jones, M., Araujo, N. C., . . . O'Neill, P. M. (2007). Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(33), 6278-6283. doi:10.1002/anie.200604697DOI: 10.1002/anie.200604697
Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds (Journal article)
Mercer, A. E., Maggs, J. L., Sun, X. -M., Cohen, G. M., Chadwick, J., O'Neill, P. M., & Park, B. K. (2007). Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds. JOURNAL OF BIOLOGICAL CHEMISTRY, 282(13), 9372-9382. doi:10.1074/jbc.M610375200DOI: 10.1074/jbc.M610375200
Back matter (Journal article)
Back matter (2007). Organic & Biomolecular Chemistry, 5(4), 708. doi:10.1039/b701157cDOI: 10.1039/b701157c
Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs (Journal article)
Stocks, P. A., Bray, P. G., Barton, V., Al-Helal, M., Jones, M., Araujo, N. C., . . . O'Neill, P. (2007). Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs. Angewandte Chemie International Edition, 46(33), 6278-6283. doi:10.1002/anie.200604697DOI: 10.1002/anie.200604697
2006
Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin (Journal article)
Amewu, R., Stachulski, A. V., Ward, S. A., Berry, N. G., Bray, P. G., Davies, J., . . . O'Neill, P. M. (2006). Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin. ORGANIC & BIOMOLECULAR CHEMISTRY, 4(24), 4431-4436. doi:10.1039/b613565jDOI: 10.1039/b613565j
Anticancer activity of artemisinin-derived trioxanes (Journal article)
Posner, G. H., D'Angelo, J., O'Neill, P. M., & Mercer, A. (2006). Anticancer activity of artemisinin-derived trioxanes. EXPERT OPINION ON THERAPEUTIC PATENTS, 16(12), 1665-1672. doi:10.1517/13543776.16.12.1665DOI: 10.1517/13543776.16.12.1665
Synthesis of 1,2,4-trioxepanes via application of thiol-olefin Co-oxygenation methodology (Journal article)
Amewu, R., Stachulski, A. V., Berry, N. G., Ward, S. A., Davies, J., Labat, G., . . . O'Neill, P. M. (2006). Synthesis of 1,2,4-trioxepanes via application of thiol-olefin Co-oxygenation methodology. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(23), 6124-6130. doi:10.1016/j.bmcl.2006.08.098DOI: 10.1016/j.bmcl.2006.08.098
PfCRT and the <i>trans</i>‐vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX (Journal article)
Bray, P. G., Mungthin, M., Hastings, I. M., Biagini, G. A., Saidu, D. K., Lakshmanan, V., . . . Ward, S. A. (2006). PfCRT and the <i>trans</i>‐vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX. Molecular Microbiology, 62(1), 238-251. doi:10.1111/j.1365-2958.2006.05368.xDOI: 10.1111/j.1365-2958.2006.05368.x
Functional Characterization and Target Validation of Alternative Complex I of
<i>Plasmodium falciparum</i>
Mitochondria (Journal article)
Biagini, G. A., Viriyavejakul, P., O'Neill, P. M., Bray, P. G., & Ward, S. A. (2006). Functional Characterization and Target Validation of Alternative Complex I of <i>Plasmodium falciparum</i> Mitochondria. Antimicrobial Agents and Chemotherapy, 50(5), 1841-1851. doi:10.1128/aac.50.5.1841-1851.2006DOI: 10.1128/aac.50.5.1841-1851.2006
A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs (Journal article)
O'Neill, P. M., Ward, S. A., Berry, N. G., Jeyadevan, J. P., Biagini, G. A., Asadollaly, E., . . . Bray, P. G. (2006). A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 6(5), 479-507. doi:10.2174/156802606776743147DOI: 10.2174/156802606776743147
Lewis acid catalysed rearrangements of unsaturated bicyclic [2.2.n] endoperoxides in the presence of vinyl silanes; access to novel Fenozan BO-7 analogues (Journal article)
O'Neill, P. M., Rawe, S. L., Storr, R. C., Ward, S. A., & Posner, G. H. (2006). Lewis acid catalysed rearrangements of unsaturated bicyclic [2.2.n] endoperoxides in the presence of vinyl silanes; access to novel Fenozan BO-7 analogues. Tetrahedron Letters, 46, 3029-3032.
2005
Current development portfolio for antimalarial therapies (Journal article)
Biagini, G. A., O'Neill, P. M., & Bray, P. G. (2005). Current development portfolio for antimalarial therapies. Current Opinion in Pharmacology, 5, 473-478.
Enantiomeric 1,2,4-Trioxanes Display Equivalent In Vitro Antimalarial Activity Versus Plasmodium falciparum Malaria Parasites: Implications for the Molecular Mechanism of Action of the Artemisinins (Journal article)
O'Neill, P. M., Rawe, S. L., Borstnik, K., Miller, A., Storr, R. C., Ward, S. A., . . . Posner, G. H. (2005). Enantiomeric 1,2,4-Trioxanes Display Equivalent In Vitro Antimalarial Activity Versus Plasmodium falciparum Malaria Parasites: Implications for the Molecular Mechanism of Action of the Artemisinins. ChemBiochem, 6, 2048-2054.
Quinolines and artemisinin: Chemistry, biology and history (Journal article)
Bray, P. G., Ward, S. A., & O'Neill, P. M. (2005). Quinolines and artemisinin: Chemistry, biology and history. CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, 295, 3-38.
The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents (Journal article)
O'Neill, P. M. (2005). The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents. Expert Opinion On Investigational Drugs, 14(9), 1117-1128.
2004
Design and Synthesis of Endoperoxide Antimalarial Prodrug Models (Journal article)
O'Neill, P. M., Stocks, P. A., Pugh, M. D., Araujo, N. C., Korshin, E. E., Bickley, J. F., . . . Bachi, M. D. (2004). Design and Synthesis of Endoperoxide Antimalarial Prodrug Models. Angewandte Chemie International Edition, 43(32), 4193-4197. doi:10.1002/anie.200453859DOI: 10.1002/anie.200453859
Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene (Journal article)
Maggs, J. L., Bishop, L. P. D., Batty, K. T., Dodd, C. C., Ilett, K. F., O’Neill, P. M., . . . Kevin Park, B. (2004). Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene. Chemico-Biological Interactions, 147(2), 173-184. doi:10.1016/j.cbi.2003.12.005DOI: 10.1016/j.cbi.2003.12.005
Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10β-(2-hydroxyethyl)deoxoartemisinin (Journal article)
Jeyadevan, J. P., Bray, P. G., Chadwick, J., Mercer, A. E., Byrne, A., Ward, S. A., . . . O'Neill, P. M. (2004). Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10β-(2-hydroxyethyl)deoxoartemisinin. JOURNAL OF MEDICINAL CHEMISTRY, 47(5), 1290-1298. doi:10.1021/jm030974cDOI: 10.1021/jm030974c
Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin (Journal article)
Jeyadevan, J. P., Bray, P. G., Chadwick, J., Mercer, A. E., Byrne, A., Ward, S. A., . . . O'Neill, P. M. (2004). Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin. Journal of Medicinal Chemistry, 47(5), 1290-1298. doi:10.1021/jm030974cDOI: 10.1021/jm030974c
A medicinal chemistry perspective on artemisinin and related endoperoxides (Journal article)
O'Neill, P. M., & Posner, G. H. (2004). A medicinal chemistry perspective on artemisinin and related endoperoxides. Journal Of Medicinal Chemistry, 47(12), 2945-2964.
Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore (Journal article)
O'Neill, P. M., Mukhtar, A., Ward, S. A., Bickley, J. F., Davies, J., Bachi, M. D., & Stocks, P. A. (2004). Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore. Organic Letters, 6(18), 3035-3038.
Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial chugs (Journal article)
Biagini, G. A., Pasini, E. M., Hughes, R., De Koning, H. P., Vial, H. J., O'Neill, P. M., . . . Bray, P. G. (2004). Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial chugs. Blood, 104(10), 3372-3377.
Knowledge of the proposed chemical mechanism of action and cytochrome P450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides (Journal article)
Posner, G. H., & O'Neill, P. M. (2004). Knowledge of the proposed chemical mechanism of action and cytochrome P450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides. Accounts Of Chemical Research, 37(6), 397-404.
Medicinal chemistry - A worthy adversary for malaria (Journal article)
O'Neill, P. M. (2004). Medicinal chemistry - A worthy adversary for malaria. Nature, 430(7002), 838-839.
T-cell recognition of carbamazepine and carbamazepine metabolites (Journal article)
Naisbitt, D. J., Wu, Y., Farrell, J., O'Neill, P. M., Pirmohamed, M., & Park, B. K. (2004). T-cell recognition of carbamazepine and carbamazepine metabolites. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 57(5), 669. Retrieved from https://www.webofscience.com/
2003
Isoquine and related amodiaquine analogues: A new generation of improved 4-aminoquinoline antimalarials (Journal article)
O'Neill, P. M., Mukhtar, A., Stocks, P. A., Randle, L. E., Hindley, S., Ward, S. A., . . . Park, B. K. (2003). Isoquine and related amodiaquine analogues: A new generation of improved 4-aminoquinoline antimalarials. JOURNAL OF MEDICINAL CHEMISTRY, 46(23), 4933-4945. doi:10.1021/jm030796nDOI: 10.1021/jm030796n
Artemisinins target the SERCA of Plasmodium falciparum (Journal article)
Eckstein-Ludwig, U., Webb, R. J., van Goethem, I. D. A., East, J. M., Lee, A. G., Kimura, M., . . . Krishna, S. (2003). Artemisinins target the SERCA of Plasmodium falciparum. Nature, 424(6951), 957-961. doi:10.1038/nature01813DOI: 10.1038/nature01813
Antimalarial chemotherapy: young guns or back to the future? (Journal article)
Biagini, G. A., O'Neill, P. M., Nzila, A., Ward, S. A., & Bray, P. G. (2003). Antimalarial chemotherapy: young guns or back to the future?. Trends In Parasitology, 19(11), 479-487.
Co(thd)(2): a superior catalyst for aerobic epoxidation and hydroperoxysilylation of unactivated alkenes: application to the synthesis of spiro-1,2,4-trioxanes (Journal article)
O'Neill, P. M., Hindley, S., Pugh, M. D., Davies, J., Bray, P. G., Park, B. K., . . . Stocks, P. A. (2003). Co(thd)(2): a superior catalyst for aerobic epoxidation and hydroperoxysilylation of unactivated alkenes: application to the synthesis of spiro-1,2,4-trioxanes. Tetrahedron Letters, 44(44), 8135-8138.
2002
Anti-malarial compounds (Patent)
Ward, S. A., O'Neill, P. M., & Park, B. K. (2002). Anti-malarial compounds.
Mechanism-based design of parasite-targeted artemisinin derivatives: Synthesis and antimalarial activity of new diamine containing analogues (Journal article)
Hindley, S., Ward, S. A., Storr, R. C., Searle, N. L., Bray, P. G., Park, B. K., . . . O'Neill, P. M. (2002). Mechanism-based design of parasite-targeted artemisinin derivatives: Synthesis and antimalarial activity of new diamine containing analogues. Journal Of Medicinal Chemistry, 45(5), 1052-1063.
Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum (Journal article)
Stocks, P. A., Raynes, K. J., Bray, P. G., Park, B. K., O'Neill, P. M., & Ward, S. A. (2002). Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum. Journal Of Medicinal Chemistry, 45(23), 4975-4983.
2001
Erratum: Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin - Synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues (Journal of the Chemical Society. Perkin Transactions 1 (2001) (2682)) (Journal article)
O'Neill, P. M., Pugh, M., Stachulski, A. V., Ward, S. A., Davies, J., & Park, B. K. (2001). Erratum: Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin - Synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues (Journal of the Chemical Society. Perkin Transactions 1 (2001) (2682)). Journal of the Chemical Society. Perkin Transactions 1, (23), 3214.
Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin: synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues (Journal article)
O'Neill, P. M., Pugh, M., Stachulski, A. V., Ward, S. A., Davies, J., & Park, B. K. (2001). Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin: synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues. Journal of the Chemical Society, Perkin Transactions 1, (20), 2682-2689. doi:10.1039/b104340bDOI: 10.1039/b104340b
Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite. (Journal article)
O'Neill, P. M., Scheinmann, F., Stachulski, A. V., Maggs, J. L., & Park, B. K. (2001). Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite.. Journal of medicinal chemistry, 44(9), 1467-1470. doi:10.1021/jm001061aDOI: 10.1021/jm001061a
Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin. (Journal article)
O'Neill, P. M., Miller, A., Bishop, L. P., Hindley, S., Maggs, J. L., Ward, S. A., . . . Park, B. K. (2001). Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin.. Journal of medicinal chemistry, 44(1), 58-68. doi:10.1021/jm000987fDOI: 10.1021/jm000987f
Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite (Journal article)
O'Neill, P. M., Scheinmann, F., Stachulski, A. V., Maggs, J. L., & Park, B. K. (2001). Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite. Journal Of Medicinal Chemistry, 44(9), 1467-1470.
Meta (Journal article)
Park, B. K., Kitteringham, N. R., & O'Neill, P. M. (2001). Meta. Annual Review Of Pharmacology And Toxicology, 41, 443-470.
Regioselective Mukaiyama hydroperoxysilylation of 2-alkyl- or 2-aryl-prop-2-en-1-ols: application to a new synthesis of 1,2,4-trioxanes (Journal article)
O'Neill, P. M., Pugh, M., Davies, J., Ward, S. A., & Park, B. K. (2001). Regioselective Mukaiyama hydroperoxysilylation of 2-alkyl- or 2-aryl-prop-2-en-1-ols: application to a new synthesis of 1,2,4-trioxanes. Tetrahedron Letters, 42(27), 4569-4571.
2000
4-Aminoquinolines as antimalarials (Patent)
Raynes, K. J., Ward, S. A., O'Neill, P. M., Stocks, P., & Park, B. K. (2000). 4-Aminoquinolines as antimalarials.
Biliary metabolites of beta-artemether in rats: Biotransformations of an antimalarial endoperoxide (Journal article)
Maggs, J. L., Bishop, L. P. D., Edwards, G., O'Neill, P. M., Ward, S. A., Winstanley, P. A., & Park, B. K. (2000). Biliary metabolites of beta-artemether in rats: Biotransformations of an antimalarial endoperoxide. Drug Metabolism And Disposition, 28(2), 209-217.
Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical (Journal article)
O'Neill, P. M., Bishop, L. P. D., Searle, N. L., Maggs, J. L., Storr, R. C., Ward, S. A., . . . Mabbs, F. (2000). Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical. Journal Of Organic Chemistry, 65(5), 1578-1582.
1999
Application of the TMSOTfAgClO4 activator system to the synthesis of novel, potent, C-10 phenoxy derivatives of dihydroartemisinin (Journal article)
O'Neill, P. M., Miller, A., Ward, S. A., Park, B. K., Scheinmann, F., & Stachulski, A. V. (1999). Application of the TMSOTfAgClO4 activator system to the synthesis of novel, potent, C-10 phenoxy derivatives of dihydroartemisinin. Tetrahedron Letters, 40(51), 9129-9132. doi:10.1016/s0040-4039(99)01891-2DOI: 10.1016/s0040-4039(99)01891-2
Asymmetric syntheses of enantiomeric 3-p-fluorophenyl 1,2,4-trioxane analogues of the antimalarial artemisinin (Journal article)
O'Neill, P. M., Miller, A., Bickley, J. F., Scheinmann, F., Chang, H. O., & Posner, G. H. (1999). Asymmetric syntheses of enantiomeric 3-p-fluorophenyl 1,2,4-trioxane analogues of the antimalarial artemisinin. Tetrahedron Letters, 40(51), 9133-9136.
Metabolism of the antimalarial endoperoxide Ro 42-1611 (arteflene) in the rat: Evidence for endoperoxide bioactivation (Journal article)
Bishop, L. P. D., Maggs, J. L., O'Neill, P. M., & Park, B. K. (1999). Metabolism of the antimalarial endoperoxide Ro 42-1611 (arteflene) in the rat: Evidence for endoperoxide bioactivation. Journal Of Pharmacology And Experimental Therapeutics, 289(1), 511-520.
New 4-aminoquinoline mannich base antimalarials. 1. Effect of an alkyl substituent in the 5 '-position of the 4 '-hydroxyanilino side chain (Journal article)
Raynes, K. J., Stocks, P. A., O'Neill, P. M., Park, B. K., & Ward, S. A. (1999). New 4-aminoquinoline mannich base antimalarials. 1. Effect of an alkyl substituent in the 5 '-position of the 4 '-hydroxyanilino side chain. Journal Of Medicinal Chemistry, 42(15), 2747-2751.
Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether (Journal article)
O'Neill, P. M., Searle, N. L., Kan, K. W., Storr, R. C., Maggs, J. L., Ward, S. A., . . . Park, B. K. (1999). Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether. Journal Of Medicinal Chemistry, 42(26), 5487-5493.
1998
Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs (Journal article)
Naisbitt, D. J., Williams, D. P., O'Neill, P. M., Maggs, J. L., Willock, D. J., Pirmohamed, M., & Park, B. K. (1998). Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs. CHEMICAL RESEARCH IN TOXICOLOGY, 11(12), 1586-1595. doi:10.1021/tx980148kDOI: 10.1021/tx980148k
Safety assessment of peroxide antimalarials: clinical and chemical perspectives (Journal article)
Park, B. K., O'Neill, P. M., Maggs, J. L., & Pirmohamed, M. (1998). Safety assessment of peroxide antimalarials: clinical and chemical perspectives. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 46(6), 521-529. doi:10.1046/j.1365-2125.1998.00838.xDOI: 10.1046/j.1365-2125.1998.00838.x
4-aminoquinolines - Past, present, and future: A chemical perspective (Journal article)
O'Neill, P. M., Bray, P. G., Hawley, S. R., Ward, S. A., & Park, B. K. (1998). 4-aminoquinolines - Past, present, and future: A chemical perspective. Pharmacology & Therapeutics, 77(1), 29-58.
A carbonyl oxide route to antimalarial yingzhaosu A analogues: Synthesis and antimalarial activity (Journal article)
O'Neill, P. M., Searle, N. L., Raynes, K. J., Maggs, J. L., Ward, S. A., Storr, R. C., . . . Posner, G. H. (1998). A carbonyl oxide route to antimalarial yingzhaosu A analogues: Synthesis and antimalarial activity. Tetrahedron Letters, 39(33), 6065-6068.
Effect of disposition of Mannich antimalarial agents on their pharmacology and toxicology (Journal article)
Ruscoe, J. E., Tingle, M. D., O'Neill, P. M., Ward, S. A., & Park, B. K. (1998). Effect of disposition of Mannich antimalarial agents on their pharmacology and toxicology. Antimicrobial Agents And Chemotherapy, 42(9), 2410-2416.
Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro (Journal article)
Hawley, S. R., Bray, P. G., Mungthin, M., Atkinson, J. D., O'Neill, P. M., & Ward, S. A. (1998). Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro. Antimicrobial Agents And Chemotherapy, 42(3), 682-686.
Synthesis of the 8-aminoquinoline antimalarial 5-fluoroprimaquine (Journal article)
O'Neill, P. M., Storr, R. C., & Park, B. K. (1998). Synthesis of the 8-aminoquinoline antimalarial 5-fluoroprimaquine. Tetrahedron, 54(18), 4615-4622.
The biliary metabolites of beta-artemether, an endoperoxide antimalarial (Journal article)
Bell, J. O., Edwards, G., Maggs, J. L., Bishop, L. P., O'Neill, P. M., Ward, S. A., . . . Park, B. K. (1998). The biliary metabolites of beta-artemether, an endoperoxide antimalarial. British Journal Of Pharmacology, 124.
1997
The rat biliary metabolites of dihydroartemisinin, an antimalarial endoperoxide (Journal article)
Maggs, J. L., Madden, S., Bishop, L. P., ONeill, P. M., & Park, B. K. (1997). The rat biliary metabolites of dihydroartemisinin, an antimalarial endoperoxide. Drug Metabolism and Disposition, 25(10), 1200-1204.
The biomimetic iron-mediated degradation of arteflene (Ro-42-1611),an endoperoxide antimalarial: Implications for the mechanism of antimalarial activity (Journal article)
O'Neill, P. M., Bishop, L. P., Searle, N. L., Maggs, J. L., Ward, S. A., Bray, P. G., . . . Kevin Park, B. (1997). The biomimetic iron-mediated degradation of arteflene (Ro-42-1611),an endoperoxide antimalarial: Implications for the mechanism of antimalarial activity. Tetrahedron Letters, 38(24), 4263-4266. doi:10.1016/s0040-4039(97)00874-5DOI: 10.1016/s0040-4039(97)00874-5
Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design (Journal article)
Naisbitt, D. J., Ruscoe, J. E., Williams, D., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1997). Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 280(2), 884-893. Retrieved from https://www.webofscience.com/
Synthesis, Antimalarial Activity, and Molecular Modeling of Tebuquine Analogues (Journal article)
O'Neill, P. M., Willock, D. J., Hawley, S. R., Bray, P. G., Storr, R. C., Ward, S. A., & Park, B. K. (1997). Synthesis, Antimalarial Activity, and Molecular Modeling of Tebuquine Analogues. Journal of Medicinal Chemistry, 40(4), 437-448. doi:10.1021/jm960370rDOI: 10.1021/jm960370r
1996
The role of drug accumulation in 4-aminoquinoline antimalarial potency - The influence of structural substitution and physicochemical properties (Journal article)
Hawley, S. R., Bray, P. G., ONeill, P. M., Park, B. K., & Ward, S. A. (1996). The role of drug accumulation in 4-aminoquinoline antimalarial potency - The influence of structural substitution and physicochemical properties. Biochemical Pharmacology, 52(5), 723-733.
Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity. (Journal article)
Naisbitt, D. J., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1996). Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 6(13), 1511-1516. doi:10.1016/S0960-894X(96)00260-0DOI: 10.1016/S0960-894X(96)00260-0
The effect of fluorine substitution on the antimalarial activity of tebuquine (Journal article)
ONeill, P. M., Hawley, S. R., Storr, R. C., Ward, S. A., & Park, B. K. (1996). The effect of fluorine substitution on the antimalarial activity of tebuquine. Bioorganic and Medicinal Chemistry Letters, 6(4), 391-392.
Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component (Journal article)
Hawley, S. R., Bray, P. G., ONeill, P. M., Naisbitt, D. J., Park, B. K., & Ward, S. A. (1996). Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 40(10), 2345-2349. doi:10.1128/AAC.40.10.2345DOI: 10.1128/AAC.40.10.2345
Mechanism-Based Design of Parasite-Targeted Artemisinin Derivatives: Synthesis and Antimalarial Activity of Benzylamino and Alkylamino Ether Analogues of Artemisinin (Journal article)
O'Neill, P. M., Bishop, L. P., Storr, R. C., Hawley, S. R., Maggs, J. L., Ward, S. A., & Park, B. K. (1996). Mechanism-Based Design of Parasite-Targeted Artemisinin Derivatives: Synthesis and Antimalarial Activity of Benzylamino and Alkylamino Ether Analogues of Artemisinin. Journal of Medicinal Chemistry, 39(22), 4511-4514. doi:10.1021/jm9604944DOI: 10.1021/jm9604944
1995
THE EFFECT OF FLUORINE SUBSTITUTION ON THE HAEMOTOXICITY OF PRIMAQUINE (Journal article)
ONEILL, P. M., TINGLE, M. D., MAHMUD, R., STORR, R. C., WARD, S. A., & PARK, B. K. (1995). THE EFFECT OF FLUORINE SUBSTITUTION ON THE HAEMOTOXICITY OF PRIMAQUINE. Bioorganic and Medicinal Chemistry Letters, 5(20), 2309-2314.
The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: Chemical mechanisms and the effects of fluorine substitution (Journal article)
Tingle, M. D., Jewell, H., Maggs, J. L., O'Neill, P. M., & Park, B. K. (1995). The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: Chemical mechanisms and the effects of fluorine substitution. Biochemical Pharmacology, 50(7), 1113-1119. doi:10.1016/0006-2952(95)00236-sDOI: 10.1016/0006-2952(95)00236-s
Quinoline Analogues of Ortho-Quinodimethane (Journal article)
White, L. (1995). Quinoline Analogues of Ortho-Quinodimethane. Tetrahedron Letters, 36(33), 5983-5986. doi:10.1016/00404-0399(50)1159f-DOI: 10.1016/00404-0399(50)1159f-
THE EFFECT OF CHEMICAL SUBSTITUTION ON THE METABOLIC-ACTIVATION, METABOLIC DETOXICATION, AND PHARMACOLOGICAL ACTIVITY OF AMODIAQUINE IN THE MOUSE (Journal article)
RUSCOE, J. E., JEWELL, H., MAGGS, J. L., ONEILL, P. M., STORR, R. C., WARD, S. A., & PARK, B. K. (1995). THE EFFECT OF CHEMICAL SUBSTITUTION ON THE METABOLIC-ACTIVATION, METABOLIC DETOXICATION, AND PHARMACOLOGICAL ACTIVITY OF AMODIAQUINE IN THE MOUSE. Journal of Pharmacology and Experimental Therapeutics, 273(1), 393-404.
Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine (Journal article)
Jewell, H., Maggs, J. L., Harrison, A. C., O'neill, P. M., Ruscoe, J. E., & Park, B. K. (1995). Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine. Xenobiotica, 25(2), 199-217. doi:10.3109/00498259509061845DOI: 10.3109/00498259509061845
1994
The Effect of Fluorine Substitution on the Metabolism and Antimalarial Activity of Amodiaquine (Journal article)
O'Neill, P. M., Harrison, A. C., Storr, R. C., Hawley, S. R., Ward, S. A., & Park, B. K. (1994). The Effect of Fluorine Substitution on the Metabolism and Antimalarial Activity of Amodiaquine. Journal of Medicinal Chemistry, 37(9), 1362-1370. doi:10.1021/jm00035a017DOI: 10.1021/jm00035a017
1993
2-Methyl-5,6-dimethylenepyrimidin-4-one: A Novel Diene (Journal article)
Tomé, A. C., O'Neill, P. M., Storr, R. C., & Cavaleiro, J. A. S. (1993). 2-Methyl-5,6-dimethylenepyrimidin-4-one: A Novel Diene. Synlett, 1993(05), 347-348. doi:10.1055/s-1993-22450DOI: 10.1055/s-1993-22450
1992
Heterocyclic fused 2,5-dihydrothiophene S,S-dioxides as precursors to heterocyclic o-quinodimethanes (Journal article)
Chaloner, L. M., Crew, A. P. A., O'Neill, P. M., Storr, R. C., & Yelland, M. (1992). Heterocyclic fused 2,5-dihydrothiophene S,S-dioxides as precursors to heterocyclic o-quinodimethanes. Tetrahedron, 48(37), 8101-8116. doi:10.1016/s0040-4020(01)80480-4DOI: 10.1016/s0040-4020(01)80480-4
