Photo of Prof Paul O'Neill

Prof Paul O'Neill BSc Hons PhD CChem MRSC

Professor Chemistry

    Publications

    2019

    AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis (Journal article)

    Hong, W. D., Benayoud, F., Nixon, G. L., Ford, L., Johnston, K. L., Clare, R. H., . . . O'Neill, P. M. (2019). AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(4), 1414-1419. doi:10.1073/pnas.1816585116

    DOI: 10.1073/pnas.1816585116

    Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides (Journal article)

    Clare, R. H., Bardelle, C., Harper, P., Hong, W. D., Borjesson, U., Johnston, K. L., . . . Ward, S. A. (2019). Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-018-07826-2

    DOI: 10.1038/s41467-018-07826-2

    2018

    Phosphinic acids: current status and potential for drug discovery. (Journal article)

    Abdou, M. M., O'Neill, P. M., Amigues, E., & Matziari, M. (2018). Phosphinic acids: current status and potential for drug discovery.. Drug discovery today. doi:10.1016/j.drudis.2018.11.016

    DOI: 10.1016/j.drudis.2018.11.016

    Potent Antimalarial 2-Pyrazolyl Quinolone bc(1) (Q(i)) Inhibitors with Improved Drug-like Properties (Journal article)

    Hong, W. D., Leung, S. C., Amporndanai, K., Davies, J., Priestley, R. S., Nixon, G. L., . . . O'Neill, P. M. (2018). Potent Antimalarial 2-Pyrazolyl Quinolone bc(1) (Q(i)) Inhibitors with Improved Drug-like Properties. ACS MEDICINAL CHEMISTRY LETTERS, 9(12), 1205-1210. doi:10.1021/acsmedchemlett.8b00371

    DOI: 10.1021/acsmedchemlett.8b00371

    Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus (Journal article)

    Stachulski, A. V., Santoro, M. G., Piacentini, S., Belardo, G., La Frazia, S., Pidathala, C., . . . Rossignol, J. -F. (2018). Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus. FUTURE MEDICINAL CHEMISTRY, 10(8), 851-862. doi:10.4155/fmc-2017-0217

    DOI: 10.4155/fmc-2017-0217

    Study of the antimalarial activity of 4-aminoquinoline compounds against chloroquine-sensitive and chloroquine-resistant parasite strains (Journal article)

    Lawrenson, A. S., Cooper, D. L., O'Neill, P. M., & Berry, N. G. (2018). Study of the antimalarial activity of 4-aminoquinoline compounds against chloroquine-sensitive and chloroquine-resistant parasite strains. JOURNAL OF MOLECULAR MODELING, 24(9). doi:10.1007/s00894-018-3755-z

    DOI: 10.1007/s00894-018-3755-z

    Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria (Journal article)

    O' Neill, P. M., Stocks, P. A., Sabbani, S., Roberts, N. L., Amewu, R. K., Shore, E. R., . . . Ward, S. A. (2018). Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria. BIOORGANIC & MEDICINAL CHEMISTRY, 26(11), 2996-3005. doi:10.1016/j.bmc.2018.05.006

    DOI: 10.1016/j.bmc.2018.05.006

    The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation (Journal article)

    Capper, M. J., Wright, G. S. A., Barbieri, L., Luchinat, E., Mercatelli, E., McAlary, L., . . . Hasnain, S. S. (2018). The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-04114-x

    DOI: 10.1038/s41467-018-04114-x

    X-ray and cryo-EM structures of inhibitor-bound cytochrome bc(1) complexes for structure-based drug discovery (Journal article)

    Amporndanai, K., Johnson, R. M., O'Neill, P. M., Fishwick, C. W. G., Jamson, A. H., Rawson, S., . . . Antonyuk, S. V. (2018). X-ray and cryo-EM structures of inhibitor-bound cytochrome bc(1) complexes for structure-based drug discovery. IUCRJ, 5, 200-210. doi:10.1107/S2052252518001616

    DOI: 10.1107/S2052252518001616

    alpha-Methyl-alpha-phenylsuccinimide ameliorates neurodegeneration in a C-elegans model of TDP-43 proteinopathy (Journal article)

    Wong, S. Q., Pontifex, M. G., Phelan, M. M., Pidathala, C., Kraemer, B. C., Barclay, J. W., . . . Morgan, A. (2018). alpha-Methyl-alpha-phenylsuccinimide ameliorates neurodegeneration in a C-elegans model of TDP-43 proteinopathy. NEUROBIOLOGY OF DISEASE, 118, 40-54. doi:10.1016/j.nbd.2018.06.013

    DOI: 10.1016/j.nbd.2018.06.013

    2017

    A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance (Journal article)

    O'Neill, P. M., Amewu, R. K., Charman, S. A., Sabbani, S., Gnadig, N. F., Straimer, J., . . . Ward, S. A. (2017). A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance. NATURE COMMUNICATIONS, 8. doi:10.1038/ncomms15159

    DOI: 10.1038/ncomms15159

    Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library (Journal article)

    Johnston, K. L., Cook, D. A. N., Berry, N. G., Hong, W. D., Clare, R. H., Goddard, M., . . . Taylor, M. J. (2017). Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library. SCIENCE ADVANCES, 3(9). doi:10.1126/sciadv.aao1551

    DOI: 10.1126/sciadv.aao1551

    Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis (Journal article)

    Hong, W. D., Gibbons, P. D., Leung, S. C., Amewu, R., Stocks, P. A., Stachulski, A., . . . Nixon, G. L. (2017). Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis. JOURNAL OF MEDICINAL CHEMISTRY, 60(9), 3703-3726. doi:10.1021/acs.jmedchem.6b01718

    DOI: 10.1021/acs.jmedchem.6b01718

    2016

    A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile (vol 55, pg 6401, 2016) (Journal article)

    Ismail, H. M., Barton, V. E., Panchana, M., Charoensutthivarakul, S., Biagini, G. A., Ward, S. A., & O'Neill, P. M. (2016). A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile (vol 55, pg 6401, 2016). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 55(36), 10548. doi:10.1002/anie.201607026

    DOI: 10.1002/anie.201607026

    A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile. (Journal article)

    Ismail, H. M., Barton, V. E., Panchana, M., Charoensutthivarakul, S., Biagini, G. A., Ward, S. A., & O'Neill, P. M. (2016). A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.. Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 128(22), 6511-6515. doi:10.1002/ange.201512062

    DOI: 10.1002/ange.201512062

    Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action (Journal article)

    Fernandez-Alvaro, E., Hong, W. D., Nixon, G. L., O'Neil, P. M., & Calderon, F. (2016). Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action. JOURNAL OF MEDICINAL CHEMISTRY, 59(12), 5587-5603. doi:10.1021/acs.jmedchem.5b01485

    DOI: 10.1021/acs.jmedchem.5b01485

    Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7 (Journal article)

    Ismail, H. M., Barton, V., Phanchana, M., Charoensutthivarakul, S., Wong, M. H. L., Hemingway, J., . . . Ward, S. A. (2016). Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(8), 2080-2085. doi:10.1073/pnas.1600459113

    DOI: 10.1073/pnas.1600459113

    Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites (Journal article)

    Wong, M. H. L., Bryan, H. K., Copple, I. M., Jenkins, R. E., Chiu, P. H., Bibby, J., . . . Park, B. K. (2016). Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites. JOURNAL OF MEDICINAL CHEMISTRY, 59(6), 2396-2409. doi:10.1021/acs.jmedchem.5b01292

    DOI: 10.1021/acs.jmedchem.5b01292

    Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD (Journal article)

    Price, K. E., Armstrong, C. M., Imlay, L. S., Hodge, D. M., Pidathala, C., Roberts, N. J., . . . John, A. R. O. (2016). Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD. SCIENTIFIC REPORTS, 6. doi:10.1038/srep36777

    DOI: 10.1038/srep36777

    Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis (Journal article)

    Shore, E. R., Awais, M., Kershaw, N. M., Gibson, R. R., Pandalanen, S., Latawiec, D., . . . Sutton, R. (2016). Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis. JOURNAL OF MEDICINAL CHEMISTRY, 59(6), 2596-2611. doi:10.1021/acs.jmedchem.5b01801

    DOI: 10.1021/acs.jmedchem.5b01801

    2015

    A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle (Journal article)

    O'Neill, P. M., & Ward, S. A. (2015). A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54(46), 13504-13506. doi:10.1002/anie.201507264

    DOI: 10.1002/anie.201507264

    Antimalarial 4(1H)-pyridones bind to the Q(i) site of cytochrome bc(1) (Journal article)

    Capper, M. J., O'Neill, P. M., Fisher, N., Strange, R. W., Moss, D., Ward, S. A., . . . Antonyuk, S. V. (2015). Antimalarial 4(1H)-pyridones bind to the Q(i) site of cytochrome bc(1). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(3), 755-760. doi:10.1073/pnas.1416611112

    DOI: 10.1073/pnas.1416611112

    Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials (Journal article)

    McConville, M., Fernandez, J., Angulo-Barturen, I., Bahamontes-Rosa, N., Ballell-Pages, L., Castaneda, P., . . . O'Neill, P. M. (2015). Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials. JOURNAL OF MEDICINAL CHEMISTRY, 58(16), 6448-6455. doi:10.1021/acs.jmedchem.5b00434

    DOI: 10.1021/acs.jmedchem.5b00434

    From hybrid compounds to targeted drug delivery in antimalarial therapy (Journal article)

    Oliveira, R., Miranda, D., Magalhaes, J., Capela, R., Perry, M. J., O'Neill, P. M., . . . Lopes, F. (2015). From hybrid compounds to targeted drug delivery in antimalarial therapy. BIOORGANIC & MEDICINAL CHEMISTRY, 23(16), 5120-5130. doi:10.1016/j.bmc.2015.04.017

    DOI: 10.1016/j.bmc.2015.04.017

    Inhibitors of the Plasmodium mitochondrial respiratory chain (Chapter)

    Nixon, G., Ward, S., O'Neill, P., & Biagini, G. (2015). Inhibitors of the Plasmodium mitochondrial respiratory chain. In Encyclopedia of Malaria (pp. 1-16). Springer-Verlag Berlin Heidelberg. doi:10.1007/978-1-4614-8757-9_15-1

    DOI: 10.1007/978-1-4614-8757-9_15-1

    Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney (Journal article)

    Shelton, L. M., Lister, A., Walsh, J., Jenkins, R. E., Wong, M. H. L., Rowe, C., . . . Copple, I. M. (2015). Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney. KIDNEY INTERNATIONAL, 88(6), 1261-1273. doi:10.1038/ki.2015.286

    DOI: 10.1038/ki.2015.286

    Plasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target (Journal article)

    Imlay, L. S., Armstrong, C. M., Masters, M. C., Li, T., Price, K. E., Edwards, R. L., . . . Odom, A. R. (2015). Plasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target. ACS INFECTIOUS DISEASES, 1(4), 157-167. doi:10.1021/id500047s

    DOI: 10.1021/id500047s

    Quinolone-Hydroxyquinoline Tautomerism in Quinolone 3-Esters. Preserving the 4-Oxoquinoline Structure To Retain Antimalarial Activity (Journal article)

    Horta, P., Kus, N., Henriques, M. S. C., Paixao, J. A., Coelho, L., Nogueira, F., . . . Santos Cristiano, M. L. (2015). Quinolone-Hydroxyquinoline Tautomerism in Quinolone 3-Esters. Preserving the 4-Oxoquinoline Structure To Retain Antimalarial Activity. JOURNAL OF ORGANIC CHEMISTRY, 80(24), 12244-12257. doi:10.1021/acs.joc.5b02169

    DOI: 10.1021/acs.joc.5b02169

    Synthesis, structural and conformational analysis, and IR spectra of ethyl 4-chloro-7-iodoquinoline-3-carboxylate (Journal article)

    Horta, P. C., Henriques, M. S. C., Kus, N., Paixao, J. A., O'Neill, P. M., Cristiano, M. L. S., & Fausto, R. (2015). Synthesis, structural and conformational analysis, and IR spectra of ethyl 4-chloro-7-iodoquinoline-3-carboxylate. TETRAHEDRON, 71(40), 7583-7592. doi:10.1016/j.tet.2015.07.076

    DOI: 10.1016/j.tet.2015.07.076

    Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57:01-restricted CD8(+) T-cell activation (Journal article)

    Naisbitt, D. J., Yang, E. L., Alhaidari, M., Berry, N. G., Lawrenson, A. S., Farrell, J., . . . Park, B. K. (2015). Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57:01-restricted CD8(+) T-cell activation. AIDS, 29(18), 2385-2395. doi:10.1097/QAD.0000000000000867

    DOI: 10.1097/QAD.0000000000000867

    2014

    4-bromopropofol decreases action potential generation in spinal neurons by inducing a glycine receptor-mediated tonic conductance (Journal article)

    Eckle, V. S., Grasshoff, C., Mirakaj, V., O'Neill, P. M., Berry, N. G., Leuwer, M., & Antkowiak, B. (2014). 4-bromopropofol decreases action potential generation in spinal neurons by inducing a glycine receptor-mediated tonic conductance. BRITISH JOURNAL OF PHARMACOLOGY, 171(24), 5790-5801. doi:10.1111/bph.12880

    DOI: 10.1111/bph.12880

    Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications (Journal article)

    Walsh, J., Jenkins, R. E., Wong, M., Olayanju, A., Powell, H., Copple, I., . . . Park, B. K. (2014). Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications. JOURNAL OF PROTEOMICS, 108, 171-187. doi:10.1016/j.jprot.2014.05.007

    DOI: 10.1016/j.jprot.2014.05.007

    Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities (Journal article)

    Miranda, D., Capela, R., Albuquerque, I. S., Meireles, P., Paiva, I., Nogueira, F., . . . Lopes, F. (2014). Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities. ACS MEDICINAL CHEMISTRY LETTERS, 5(2), 108-112. doi:10.1021/ml4002985

    DOI: 10.1021/ml4002985

    Novel inhibitors of the Plasmodium falciparum electron transport chain (Journal article)

    Stocks, P. A., Barton, V., Antoine, T., Biagini, G. A., Ward, S. A., & O'Neill, P. M. (2014). Novel inhibitors of the Plasmodium falciparum electron transport chain. PARASITOLOGY, 141(1), 50-65. doi:10.1017/S0031182013001571

    DOI: 10.1017/S0031182013001571

    Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential (Journal article)

    Antoine, T., Fisher, N., Amewu, R., ONeill, P. M., Ward, S. A., & Biagini, G. A. (2014). Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 69(4), 1005-1016. doi:10.1093/jac/dkt486

    DOI: 10.1093/jac/dkt486

    Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials. (Journal article)

    Oliveira, R., Guedes, R. C., Meireles, P., Albuquerque, I. S., Gonçalves, L. M., Pires, E., . . . Lopes, F. (2014). Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials.. Journal of medicinal chemistry, 57(11), 4916-4923. doi:10.1021/jm5004528

    DOI: 10.1021/jm5004528

    2013

    Antimalarial pharmacology and therapeutics of atovaquone (Journal article)

    Nixon, G. L., Moss, D. M., Shone, A. E., Lalloo, D. G., Fisher, N., O'Neill, P. M., . . . Biagini, G. A. (2013). Antimalarial pharmacology and therapeutics of atovaquone. Journal of Antimicrobial Chemotherapy, 68(5), 977-985. doi:10.1093/jac/dks504

    DOI: 10.1093/jac/dks504

    Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation (Journal article)

    La Pensee, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A. E., . . . O'Neill, P. M. (2013). Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation. CHEMMEDCHEM, 8(5), 709-718. doi:10.1002/cmdc.201200536

    DOI: 10.1002/cmdc.201200536

    Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation (Journal article)

    La Pensée, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A. E., . . . O'Neill, P. M. (2013). Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation. ChemMedChem, 8(5), 709-718.

    Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions (Journal article)

    Ismail, H. M., O'Neill, P. M., Hong, D. W., Finn, R. D., Henderson, C. J., Wright, A. T., . . . Paine, M. J. I. (2013). Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions. Proceedings of the National Academy of Sciences, 110(49), 19766-19771. doi:10.1073/pnas.1320185110

    DOI: 10.1073/pnas.1320185110

    Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era (Journal article)

    Nixon, G. L., Pidathala, C., Shone, A. E., Antoine, T., Fisher, N., O'Neill, P. M., . . . Biagini, G. A. (2013). Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era. FUTURE MEDICINAL CHEMISTRY, 5(13), 1573-1591. doi:10.4155/fmc.13.121

    DOI: 10.4155/fmc.13.121

    X-ray Crystallography and Computational Docking for the Detection and Development of Protein-Ligand Interactions (Journal article)

    Kershaw, N. M., Wright, G. S. A., Sharma, R., Antonyuk, S. V., Strange, R. W., Berry, N. G., . . . Hasnain, S. S. (2013). X-ray Crystallography and Computational Docking for the Detection and Development of Protein-Ligand Interactions. CURRENT MEDICINAL CHEMISTRY, 20(4), 569-575. Retrieved from http://gateway.webofknowledge.com/

    2012

    Antimalarial pharmacology and therapeutics of atovaquone (Journal article)

    Nixon, G. L., Moss, D. M., Shone, A. E., Lalloo, D. G., Fisher, N., O'Neill, P. M., . . . Biagini, G. A. (2013). Antimalarial pharmacology and therapeutics of atovaquone. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 68(5), 977-985. doi:10.1093/jac/dks504

    DOI: 10.1093/jac/dks504

    Antitubercular pharmacodynamics of phenothiazines (Journal article)

    Warman, A. J., Rito, T. S., Fisher, N. E., Moss, D. M., Berry, N. G., O'Neill, P. M., . . . Biagini, G. A. (2013). Antitubercular pharmacodynamics of phenothiazines. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 68(4), 869-880. doi:10.1093/jac/dks483

    DOI: 10.1093/jac/dks483

    Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc(1) Catalytic Turnover and Protein Expression (Journal article)

    Fisher,, N., Majid,, R. A., Antoine,, T., Al-Helal,, M., Warman,, A. J., Johnson,, D. J., . . . Biagini,, G. A. (2012). Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc(1) Catalytic Turnover and Protein Expression. Journal of Biological Chemistry, 287, 9731-9741.

    Examination of the Cytotoxic and Embryotoxic Potential, and Underlying Mechanisms, of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials (Journal article)

    Copple, I., Chadwick, A., Firman, J., Donegan, G., Herpers, B., Wong, M. H. L., . . . Park, K. (2012). Examination of the Cytotoxic and Embryotoxic Potential, and Underlying Mechanisms, of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials. Molecular Medicine, 18, 1045-1055.

    Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain (Journal article)

    Shone, A. E., Fisher, N., Mubaraki, M. A., Srivastava, A., Hill, A., Antoine, T., . . . Berry, N. (2012). Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain. Proceedings of the National Academy of Sciences of the United States of America, (109), 8298-8303.

    Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria (Journal article)

    Biagini, G. A., Fisher, N., Shone, A. E., Mubaraki, M. A., Srivastava, A., Hill, A., . . . Ward, S. A. (2012). Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(21), 8298-8303. doi:10.1073/pnas.1205651109

    DOI: 10.1073/pnas.1205651109

    HDQ, A Potent Inhibitor Of Plasmodium Falciparum Proliferation Binds To The Qi Site Of The Bc1 Complex (Journal article)

    Vallières, C., Fisher, N., Antoine, T., Al-Helal, M., Stocks, P., Berry, N. G., . . . Meunier, B. (2012). HDQ, A Potent Inhibitor Of Plasmodium Falciparum Proliferation Binds To The Qi Site Of The Bc1 Complex. Antimicrobial Agents and Chemotherapy, 56, 3739-3747.

    HDQ, a Potent Inhibitor of Plasmodium falciparum Proliferation, Binds to the Quinone Reduction Site of the Cytochrome bc(1) Complex (Journal article)

    Vallieres,, C., Fisher,, N., Antoine,, T., Al-Helal,, M., Stocks,, P., Berry,, N. G., . . . Meunier,, B. (2012). HDQ, a Potent Inhibitor of Plasmodium falciparum Proliferation, Binds to the Quinone Reduction Site of the Cytochrome bc(1) Complex. Antimicrobial Agents and Chemotherapy, 56, 3739-3747.

    Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods (Journal article)

    Sharma, R., Lawrenson, A. S., Fisher, N. E., Warman, A. J., Shone, A. E., Hill, A., . . . Berry, N. G. (2012). Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods. JOURNAL OF MEDICINAL CHEMISTRY, 55(7), 3144-3154. doi:10.1021/jm3001482

    DOI: 10.1021/jm3001482

    Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2) (Journal article)

    Pidathala, C., Amewu, R., Pacorel, B., Nixon, G. L., Gibbons, P., Hong, W. D., . . . O'Neill, P. M. (2012). Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2). JOURNAL OF MEDICINAL CHEMISTRY, 55(5), 1831-1843. doi:10.1021/jm201179h

    DOI: 10.1021/jm201179h

    Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2) (Journal article)

    Leung, S. C., Gibbons, P., Amewu, R., Nixon, G. L., Pidathala, C., Hong, W. D., . . . O'Neill, P. M. (2012). Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2). JOURNAL OF MEDICINAL CHEMISTRY, 55(5), 1844-1857. doi:10.1021/jm201184h

    DOI: 10.1021/jm201184h

    The MEP pathway and the development of inhibitors as potential anti-infective agents (Journal article)

    Hale, I., O'Neill, P. M., Berry, N. G., Odom, A., & Sharma, R. (2012). The MEP pathway and the development of inhibitors as potential anti-infective agents. MEDCHEMCOMM, 3(4), 418-433. doi:10.1039/c2md00298a

    DOI: 10.1039/c2md00298a

    The development of quinolone esters as novel antimalarial agents targeting the Plasmodium falciparum bc(1) protein complex (Journal article)

    Cowley, R., Leung, S., Fisher, N., Al-Helal, M., Berry, N. G., Lawrenson, A. S., . . . O'Neill, P. M. (2012). The development of quinolone esters as novel antimalarial agents targeting the Plasmodium falciparum bc(1) protein complex. MEDCHEMCOMM, 3(1), 39-44. doi:10.1039/c1md00183c

    DOI: 10.1039/c1md00183c

    2011

    Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action (Journal article)

    Chadwick, J., Amewu, R. K., Marti, F., Bousejra-El Garah, F., Sharma, R., Berry, N. G., . . . O'Neill, P. M. (2011). Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action. CHEMMEDCHEM, 6(8), 1357-1361. doi:10.1002/cmdc.201100196

    DOI: 10.1002/cmdc.201100196

    Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action (Journal article)

    Chadwick, J., Amewu, R. K., Marti, F., Bousejra-El Garah, F., Sharma, R., Berry, N. G., . . . O'Neill, P. M. (2011). Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action. Chemmedchem, 6, 1357-1361.

    Comparison of the Reactivity of Antimalarial 1,2,4,5-Tetraoxanes with 1,2,4-Trioxolanes in the Presence of Ferrous Iron Salts, Heme, and Ferrous Iron Salts/Phosphatidylcholine (Journal article)

    Bousejra-El Garah, F., Wong, M. H., Amewu, R. K., Muangnoicharoen, S., Maggs, J. L., Stigliani, J. -L., . . . O'Neill, P. M. (2011). Comparison of the Reactivity of Antimalarial 1,2,4,5-Tetraoxanes with 1,2,4-Trioxolanes in the Presence of Ferrous Iron Salts, Heme, and Ferrous Iron Salts/Phosphatidylcholine. Journal of Medicinal Chemistry, 54, 6443-6455.

    Convenient Syntheses of Benzo-Fluorinated Dibenz[b,f]azepines: Rearrangements of Isatins, Acridines, and Indoles (Journal article)

    Elliott, E. C., Bowkett, E. R., Maggs, J. L., Bacsa, J., Park, B. K., Regan, S. L., . . . Stachulski, A. V. (2011). Convenient Syntheses of Benzo-Fluorinated Dibenz[b,f]azepines: Rearrangements of Isatins, Acridines, and Indoles. Organic Letters, 13, 5592-5595.

    Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed (Journal article)

    Stevenson, B. J., Bibby, J., Pignatelli, P., Muangnoicharoen, S., O'Neill, P. M., Lian, L. Y., . . . Paine, M. J. I. (2011). Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed. Insect Biochemistry and Molecular Biology, 41, 492-502.

    Identification of new antimalarial leads by use of virtual screening against cytochrome bc(1) (Journal article)

    Rodrigues, T., Moreira, R., Gut, J., Rosenthal, P. J., O'Neill, P. M., Biagini, G. A., . . . Guedes, R. C. (2011). Identification of new antimalarial leads by use of virtual screening against cytochrome bc(1). Bioorganic & Medicinal Chemistry, 19, 6302-6308.

    Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities (Journal article)

    Marti,, F., Chadwick,, J., Amewu,, R. K., Burrell-Saward,, H., Srivastava,, A., Ward,, S. A., . . . O'Neill,, P. M. (2011). Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities. Medchemcomm, 2(661-66).

    Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities (Journal article)

    Marti, F., Chadwick, J., Amewu, R. K., Burrell-Saward, H., Srivastava, A., Ward, S. A., . . . O'Neill, P. M. (2011). Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities. MEDCHEMCOMM, 2(7), 661-665. doi:10.1039/c1md00102g

    DOI: 10.1039/c1md00102g

    Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues (Journal article)

    Berger, O., Kaniti, A., van Ba, C. T., Vial, H., Ward, S. A., Biagini, G. A., . . . O'Neill, P. M. (2011). Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues. Chemmedchem, 6, 2094-2108.

    The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials (Journal article)

    Mercer, A. E., Copple, I. M., Maggs, J. L., O'Neill, P. M., & Park, B. K. (2011). The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(2), 987-996. doi:10.1074/jbc.M110.144188

    DOI: 10.1074/jbc.M110.144188

    The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials (Journal article)

    Mercer, A. E., Copple, I. M., Maggs, J. L., O'Neill, P. M., & Park, B. K. (2011). The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials. Journal of Biological Chemistry, 286, 987-996.

    2010

    A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum (Journal article)

    Fisher, N., Hill, A., Mbekeani, A., Shone, A., Nixon, G., Stocks, P., . . . Biagini, G. A. (2010). A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1797, 80. doi:10.1016/j.bbabio.2010.04.241

    DOI: 10.1016/j.bbabio.2010.04.241

    A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum (Journal article)

    Fisher, N., Hill, A., Mbekeani, A., Shone, A., Nixon, G., Stocks, P., . . . Biagini, G. A. (2010). A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum. Biochimica Et Biophysica Acta-Bioenergetics, 1797, 80.

    Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines (Journal article)

    Chadwick, J., Jones, M., Mercer, A. E., Stocks, P. A., Ward, S. A., Park, B. K., & O'Neill, P. M. (2010). Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines. BIOORGANIC & MEDICINAL CHEMISTRY, 18(7), 2586-2597. doi:10.1016/j.bmc.2010.02.035

    DOI: 10.1016/j.bmc.2010.02.035

    Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH:quinone oxidoreductase (Journal article)

    Biagini, G. A., Hill, A., Mbekeani, A., Shone, A., Nixon, G., Stocks, P., . . . Ward, S. A. (2010). Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH:quinone oxidoreductase. Malaria Journal, 9(Suppl 2), O4. doi:10.1186/1475-2875-9-S2-O4

    DOI: 10.1186/1475-2875-9-S2-O4

    Diastereoselective schenck ene reaction of singlet oxygen with chiral allylic alcohols; access to enantiomerically enriched 1,2,4-trioxanes (Journal article)

    Sabbani, S., La Pensee, L., Bacsa, J., Hedenstrom, E., & O'Neill, P. M. (2010). Diastereoselective schenck ene reaction of singlet oxygen with chiral allylic alcohols; access to enantiomerically enriched 1,2,4-trioxanes. Tetrahedron, 65, 8531-8537.

    Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity (Journal article)

    Gibbons, P., Verissimo, E., Araujo, N. C., Barton, V., Nixon, G. L., Amewu, R. K., . . . O'Neill, P. M. (2010). Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity. JOURNAL OF MEDICINAL CHEMISTRY, 53(22), 8202-8206. doi:10.1021/jm1009567

    DOI: 10.1021/jm1009567

    Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins (Journal article)

    O'Neill, P. M., Amewu, R. K., Nixon, G. L., ElGarah, F. B., Mungthin, M., Chadwick, J., . . . Ward, S. A. (2010). Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 49(33), 5693-5697. doi:10.1002/anie.201001026

    DOI: 10.1002/anie.201001026

    Inhibiting Plasmodium cytochrome bc(1): a complex issue (Journal article)

    Barton, V., Fisher, N., Biagini, G. A., Ward, S. A., & O'Neill, P. M. (2010). Inhibiting Plasmodium cytochrome bc(1): a complex issue. Current Opinion in Chemical Biology, 14, 440-446.

    Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives (Journal article)

    Castrejon, J. L., Lavergne, S. N., El-Sheikh, A., Farrell, J., Maggs, J. L., Sabbani, S., . . . Naisbitt, D. J. (2010). Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives. CHEMICAL RESEARCH IN TOXICOLOGY, 23(1), 184-192. doi:10.1021/tx900329b

    DOI: 10.1021/tx900329b

    Modular Synthesis and in Vitro and in Vivo Antimalarial Assessment of C-10 Pyrrole Mannich Base Derivatives of Artemisinin (Journal article)

    Pacorel, B., Leung, S. C., Stachulski, A. V., Davies, J., Vivas, L., Lander, H., . . . O'Neill, P. M. (2010). Modular Synthesis and in Vitro and in Vivo Antimalarial Assessment of C-10 Pyrrole Mannich Base Derivatives of Artemisinin. Journal of Medicinal Chemistry, 53(2), 633-640.

    Rationale Design of Biotinylated Antimalarial Endoperoxide Carbon Centered Radical Prodrugs for Applications in Proteomics (Journal article)

    Barton, V., Ward, S. A., Chadwick, J., Hill, A., & Oneill, P. M. (2010). Rationale Design of Biotinylated Antimalarial Endoperoxide Carbon Centered Radical Prodrugs for Applications in Proteomics. Journal of Medicinal Chemistry, 53, 4555-4559.

    Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates (Journal article)

    Araujo, N. P., Barton, V., Jones, M., Stocks, P. A., Ward, S. A., Davies, J., . . . O'Neill, P. M. (2010). Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates. Bioorganic & Medicinal Chemistry Letters, 19, 2038.

    Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols (Journal article)

    Amewu, R., Gibbons, P., Mukhtar, A., Stachulski, A. V., Ward, S. A., Hall, C., . . . O'Neill, P. M. (2010). Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols. ORGANIC & BIOMOLECULAR CHEMISTRY, 8(9), 2068-2077. doi:10.1039/b924319d

    DOI: 10.1039/b924319d

    Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols (Journal article)

    Amewu, R., Gibbons, P., Mukhtar, A., Stachulski, A. V., Ward, S. A., Hall, C., . . . O'Neill, P. M. (2010). Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols. Organic & Biomolecular Chemistry, 8, 2068-2077.

    The Molecular Mechanism of Action of Artemisinin-The Debate Continues (Journal article)

    O'Neill, P. M., Barton, V. E., & Ward, S. A. (2010). The Molecular Mechanism of Action of Artemisinin-The Debate Continues. Molecules, 15, 1705-1721.

    The type II NADH: Quinone oxidoreductase of Mycobacterium tuberculosis: A novel drug target for an age-old problem (Journal article)

    Warman, A. J., Rito, T., Fisher, N., Berry, N. G., O'Neill, P. M., Ward, S. A., & Biagini, G. A. (2010). The type II NADH: Quinone oxidoreductase of Mycobacterium tuberculosis: A novel drug target for an age-old problem. Biochimica Et Biophysica Acta-Bioenergetics, 1797, 117-118.

    2009

    Antitumour and antimalarial activity of artemisinin-acridine hybrids (Journal article)

    Jones, M., Mercer, A. E., Stocks, P. A., La Pensee, L. J. I., Cosstick, R., Park, B. K., . . . O'Neill, P. M. (2009). Antitumour and antimalarial activity of artemisinin-acridine hybrids. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(7), 2033-2037. doi:10.1016/j.bmcl.2009.02.028

    DOI: 10.1016/j.bmcl.2009.02.028

    Antitumour and antimalarial activity of artemisinin-acridine hybrids (Journal article)

    Jones, M., Mercer, A. E., Stocks, P. A., La Pensee, L. J., Cosstick, R., Park, B. K., . . . O'Neill, P. M. (2009). Antitumour and antimalarial activity of artemisinin-acridine hybrids. Bioorganic & Medicinal Chemistry Letters, 19, 2033-2037.

    Antitumour and antimalarial activity of artemisinin–acridine hybrids (Journal article)

    Jones, M., Mercer, A. E., Stocks, P. A., La Pensée, L. J., Cosstick, R., Park, B. K., . . . O’Neill, P. M. (2009). Antitumour and antimalarial activity of artemisinin–acridine hybrids. Bioorganic & Medicinal Chemistry Letters, 19(7), 2033-2037. doi:10.1016/j.bmcl.2009.02.028

    DOI: 10.1016/j.bmcl.2009.02.028

    Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century (Journal article)

    O'Neill, P. M., Park, B. K., Shone, A. E., Maggs, J. L., Roberts, P., Stocks, P. A., . . . Ward, S. A. (2009). Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century. JOURNAL OF MEDICINAL CHEMISTRY, 52(5), 1408-1415. doi:10.1021/jm8012618

    DOI: 10.1021/jm8012618

    Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials (Journal article)

    Davis, C. B., Bambal, R., Moorthy, G. S., Hugger, E., Xiang, H., Park, B. K., . . . Ward, S. A. (2009). Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials. Journal of Pharmaceutical Sciences, 98(1), 362-377. doi:10.1002/jps.21469

    DOI: 10.1002/jps.21469

    Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P-falciparum malaria parasites and HL-60 cancer cells (Journal article)

    Chadwick, J., Mercer, A. E., Park, B. K., Cosstick, R., & O'Neill, P. M. (2009). Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P-falciparum malaria parasites and HL-60 cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY, 17(3), 1325-1338. doi:10.1016/j.bmc.2008.12.017

    DOI: 10.1016/j.bmc.2008.12.017

    Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P-falciparum malaria parasites and HL-60 cancer cells (Journal article)

    Chadwick, J., Mercer, A. E., Park, B. K., Cosstick, R., & O'Neill, P. M. (2009). Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P-falciparum malaria parasites and HL-60 cancer cells. Bioorganic & Medicinal Chemistry, 17, 1325-1338.

    Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4 '-Fluoro and 4 '-Chloro Analogues of Amodiaquine. Identification of a Suitable "Back-Up" Compound for N-tert-Butyl Isoquine (Journal article)

    O'Neill, P. M., Shone, A. E., Stanford, D., Nixon, G., Asadollahy, E., Park, B. K., . . . Ward, S. A. (2009). Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4 '-Fluoro and 4 '-Chloro Analogues of Amodiaquine. Identification of a Suitable "Back-Up" Compound for N-tert-Butyl Isoquine. JOURNAL OF MEDICINAL CHEMISTRY, 52(7), 1828-1844. doi:10.1021/jm8012757

    DOI: 10.1021/jm8012757

    2008

    Acridinediones: Selective and potent inhibitors of the malaria parasite mitochondrial bc(1) complex (Journal article)

    Biagini, G. A., Fisher, N., Berry, N., Stocks, P. A., Meunier, B., Williams, D. P., . . . Ward, S. A. (2008). Acridinediones: Selective and potent inhibitors of the malaria parasite mitochondrial bc(1) complex. MOLECULAR PHARMACOLOGY, 73(5), 1347-1355. doi:10.1124/mol.108.045120

    DOI: 10.1124/mol.108.045120

    An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity (Journal article)

    Ellis, G. L., Amewu, R., Hall, C., Rimmer, K., Ward, S. A., & O'Neill, P. M. (2008). An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(5), 1720-1724. doi:10.1016/j.bmcl.2008.01.053

    DOI: 10.1016/j.bmcl.2008.01.053

    An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity (Journal article)

    Ellis, G. L., Amewu, R., Hall, C., Rimmer, K., Ward, S. A., & O’Neill, P. M. (2008). An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity. Bioorganic & Medicinal Chemistry Letters, 18(5), 1720-1724. doi:10.1016/j.bmcl.2008.01.053

    DOI: 10.1016/j.bmcl.2008.01.053

    Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors (Journal article)

    Verissimo, E., Berry, N., Gibbons, P., Cristiano, M. L. S., Rosenthal, P. J., Gut, J., . . . O'Neill, P. M. (2008). Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(14), 4210-4214. doi:10.1016/j.bmcl.2008.05.068

    DOI: 10.1016/j.bmcl.2008.05.068

    Piperidine dispiro-1,2,4-trioxane analogues (Journal article)

    Sabbani, S., Stocks, P. A., Ellis, G. L., Davies, J., Hedenstrom, E., Ward, S. A., & O'Neill, P. M. (2008). Piperidine dispiro-1,2,4-trioxane analogues. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(21), 5804-5808. doi:10.1016/j.bmcl.2008.09.052

    DOI: 10.1016/j.bmcl.2008.09.052

    Piperidine dispiro-1,2,4-trioxane analogues (Journal article)

    Sabbani, S., Stocks, P. A., Ellis, G. L., Davies, J., Hedenstrom, E., Ward, S. A., & O'Neill, P. M. (2008). Piperidine dispiro-1,2,4-trioxane analogues. Bioorganic & Medicinal Chemistry Letters, 18, 5804-5808.

    Stimulation of nitroso sulfamethoxazole-specific T-cells with structurally-related hydroxylamine and nitroso metabolites (Journal article)

    Castrejon, J. L., Farrell, J., O'neill, P. M., Park, B. K., & Naisbitt, D. J. (2008). Stimulation of nitroso sulfamethoxazole-specific T-cells with structurally-related hydroxylamine and nitroso metabolites. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 65(6), 997. Retrieved from http://gateway.webofknowledge.com/

    Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles (Journal article)

    Ellis, G. L., Amewu, R., Sabbani, S., Stocks, P. A., Shone, A., Stanford, D., . . . O'Neill, P. M. (2008). Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles. JOURNAL OF MEDICINAL CHEMISTRY, 51(7), 2170-2177. doi:10.1021/jm701435h

    DOI: 10.1021/jm701435h

    Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles (Journal article)

    Ellis, G. L., Amewu, R., Sabbani, S., Stocks, P. A., Shone, A., Stanford, D., . . . O'Neill, P. M. (2008). Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles. Journal of Medicinal Chemistry, 51, 2170-2177.

    2007

    Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs (Journal article)

    Stocks, P. A., Bray, P. G., Barton, V., Al-Helal, M., Jones, M., Araujo, N. C., . . . O'Neill, P. (2007). Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs. Angewandte Chemie International Edition, 46(33), 6278-6283. doi:10.1002/anie.200604697

    DOI: 10.1002/anie.200604697

    Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds (Journal article)

    Mercer, A. E., Maggs, J. L., Sun, X. -M., Cohen, G. M., Chadwick, J., O'Neill, P. M., & Park, B. K. (2007). Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds. JOURNAL OF BIOLOGICAL CHEMISTRY, 282(13), 9372-9382. doi:10.1074/jbc.M610375200

    DOI: 10.1074/jbc.M610375200

    2006

    Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin (Journal article)

    Amewu, R., Stachulski, A. V., Ward, S. A., Berry, N. G., Bray, P. G., Davies, J., . . . O'Neill, P. M. (2006). Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin. ORGANIC & BIOMOLECULAR CHEMISTRY, 4(24), 4431-4436. doi:10.1039/b613565j

    DOI: 10.1039/b613565j

    Functional Characterization and Target Validation of Alternative Complex I of Plasmodium falciparum Mitochondria (Journal article)

    Biagini, G. A., Viriyavejakul, P., O'Neill, P. M., Bray, P. G., & Ward, S. A. (2006). Functional Characterization and Target Validation of Alternative Complex I of Plasmodium falciparum Mitochondria. Antimicrobial Agents and Chemotherapy, 50(5), 1841-1851. doi:10.1128/AAC.50.5.1841-1851.2006

    DOI: 10.1128/AAC.50.5.1841-1851.2006

    Lewis acid catalysed rearrangements of unsaturated bicyclic [2.2.n] endoperoxides in the presence of vinyl silanes; access to novel Fenozan BO-7 analogues (Journal article)

    O'Neill, P. M., Rawe, S. L., Storr, R. C., Ward, S. A., & Posner, G. H. (2006). Lewis acid catalysed rearrangements of unsaturated bicyclic [2.2.n] endoperoxides in the presence of vinyl silanes; access to novel Fenozan BO-7 analogues. Tetrahedron Letters, 46, 3029-3032.

    PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX (Journal article)

    Bray, P. G., Mungthin, M., Hastings, I. M., Biagini, G. A., Saidu, D. K., Lakshmanan, V., . . . Ward, S. A. (2006). PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX. Molecular Microbiology, 62(1), 238-251. doi:10.1111/j.1365-2958.2006.05368.x

    DOI: 10.1111/j.1365-2958.2006.05368.x

    Synthesis of 1,2,4-trioxepanes via application of thiol-olefin Co-oxygenation methodology (Journal article)

    Amewu, R., Stachulski, A. V., Berry, N. G., Ward, S. A., Davies, J., Labat, G., . . . O'Neill, P. M. (2006). Synthesis of 1,2,4-trioxepanes via application of thiol-olefin Co-oxygenation methodology. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(23), 6124-6130. doi:10.1016/j.bmcl.2006.08.098

    DOI: 10.1016/j.bmcl.2006.08.098

    2005

    Current development portfolio for antimalarial therapies (Journal article)

    Biagini, G. A., O'Neill, P. M., & Bray, P. G. (2005). Current development portfolio for antimalarial therapies. Current Opinion in Pharmacology, 5, 473-478.

    Enantiomeric 1,2,4-Trioxanes Display Equivalent In Vitro Antimalarial Activity Versus Plasmodium falciparum Malaria Parasites: Implications for the Molecular Mechanism of Action of the Artemisinins (Journal article)

    O'Neill, P. M., Rawe, S. L., Borstnik, K., Miller, A., Storr, R. C., Ward, S. A., . . . Posner, G. H. (2005). Enantiomeric 1,2,4-Trioxanes Display Equivalent In Vitro Antimalarial Activity Versus Plasmodium falciparum Malaria Parasites: Implications for the Molecular Mechanism of Action of the Artemisinins. ChemBiochem, 6, 2048-2054.

    Quinolines and artemisinin: Chemistry, biology and history (Journal article)

    Bray, P. G., Ward, S. A., & O'Neill, P. M. (2005). Quinolines and artemisinin: Chemistry, biology and history. CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, 295, 3-38.

    The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents (Journal article)

    O'Neill, P. M. (2005). The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents. Expert Opinion On Investigational Drugs, 14(9), 1117-1128.

    2004

    A medicinal chemistry perspective on artemisinin and related endoperoxides (Journal article)

    O'Neill, P. M., & Posner, G. H. (2004). A medicinal chemistry perspective on artemisinin and related endoperoxides. Journal Of Medicinal Chemistry, 47(12), 2945-2964.

    Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin (Journal article)

    Jeyadevan, J. P., Bray, P. G., Chadwick, J., Mercer, A. E., Byrne, A., Ward, S. A., . . . O'Neill, P. M. (2004). Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin. Journal of Medicinal Chemistry, 47(5), 1290-1298. doi:10.1021/jm030974c

    DOI: 10.1021/jm030974c

    Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10 beta-(2-hydroxyethyl)deoxoartemisinin (Journal article)

    Jeyadevan, J. P., Bray, P. G., Chadwick, J., Mercer, A. E., Byrne, A., Ward, S. A., . . . O'Neill, P. M. (2004). Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10 beta-(2-hydroxyethyl)deoxoartemisinin. JOURNAL OF MEDICINAL CHEMISTRY, 47(5), 1290-1298. doi:10.1021/jm030974c

    DOI: 10.1021/jm030974c

    Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore (Journal article)

    O'Neill, P. M., Mukhtar, A., Ward, S. A., Bickley, J. F., Davies, J., Bachi, M. D., & Stocks, P. A. (2004). Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore. Organic Letters, 6(18), 3035-3038.

    Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial chugs (Journal article)

    Biagini, G. A., Pasini, E. M., Hughes, R., De Koning, H. P., Vial, H. J., O'Neill, P. M., . . . Bray, P. G. (2004). Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial chugs. Blood, 104(10), 3372-3377.

    Design and Synthesis of Endoperoxide Antimalarial Prodrug Models (Journal article)

    O'Neill, P. M., Stocks, P. A., Pugh, M. D., Araujo, N. C., Korshin, E. E., Bickley, J. F., . . . Bachi, M. D. (2004). Design and Synthesis of Endoperoxide Antimalarial Prodrug Models. Angewandte Chemie International Edition, 43(32), 4193-4197. doi:10.1002/anie.200453859

    DOI: 10.1002/anie.200453859

    Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene (Journal article)

    Maggs, J. L., Bishop, L. P., Batty, K. T., Dodd, C. C., Ilett, K. F., O’Neill, P. M., . . . Kevin Park, B. (2004). Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene. Chemico-Biological Interactions, 147(2), 173-184. doi:10.1016/j.cbi.2003.12.005

    DOI: 10.1016/j.cbi.2003.12.005

    Knowledge of the proposed chemical mechanism of action and cytochrome P450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides (Journal article)

    Posner, G. H., & O'Neill, P. M. (2004). Knowledge of the proposed chemical mechanism of action and cytochrome P450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides. Accounts Of Chemical Research, 37(6), 397-404.

    Medicinal chemistry - A worthy adversary for malaria (Journal article)

    O'Neill, P. M. (2004). Medicinal chemistry - A worthy adversary for malaria. Nature, 430(7002), 838-839.

    T-cell recognition of carbamazepine and carbamazepine metabolites (Journal article)

    Naisbitt, D. J., Wu, Y., Farrell, J., O'Neill, P. M., Pirmohamed, M., & Park, B. K. (2004). T-cell recognition of carbamazepine and carbamazepine metabolites. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 57(5), 669. Retrieved from http://gateway.webofknowledge.com/

    2003

    Antimalarial chemotherapy: young guns or back to the future? (Journal article)

    Biagini, G. A., O'Neill, P. M., Nzila, A., Ward, S. A., & Bray, P. G. (2003). Antimalarial chemotherapy: young guns or back to the future?. Trends In Parasitology, 19(11), 479-487.

    Artemisinins target the SERCA of Plasmodium falciparum (Journal article)

    Eckstein-Ludwig, U., Webb, R. J., van Goethem, I. D. A., East, J. M., Lee, A. G., Kimura, M., . . . Krishna, S. (2003). Artemisinins target the SERCA of Plasmodium falciparum. Nature, 424(6951), 957-961. doi:10.1038/nature01813

    DOI: 10.1038/nature01813

    Co(thd)(2): a superior catalyst for aerobic epoxidation and hydroperoxysilylation of unactivated alkenes: application to the synthesis of spiro-1,2,4-trioxanes (Journal article)

    O'Neill, P. M., Hindley, S., Pugh, M. D., Davies, J., Bray, P. G., Park, B. K., . . . Stocks, P. A. (2003). Co(thd)(2): a superior catalyst for aerobic epoxidation and hydroperoxysilylation of unactivated alkenes: application to the synthesis of spiro-1,2,4-trioxanes. Tetrahedron Letters, 44(44), 8135-8138.

    Isoquine and Related Amodiaquine Analogues:  A New Generation of Improved 4-Aminoquinoline Antimalarials (Journal article)

    O'Neill, P. M., Mukhtar, A., Stocks, P. A., Randle, L. E., Hindley, S., Ward, S. A., . . . Park, B. K. (2003). Isoquine and Related Amodiaquine Analogues:  A New Generation of Improved 4-Aminoquinoline Antimalarials. Journal of Medicinal Chemistry, 46(23), 4933-4945. doi:10.1021/jm030796n

    DOI: 10.1021/jm030796n

    2002

    Anti-malarial compounds (Patent)

    Ward, S. A., O'Neill, P. M., & Park, B. K. (2002). Anti-malarial compounds.

    Mechanism-based design of parasite-targeted artemisinin derivatives: Synthesis and antimalarial activity of new diamine containing analogues (Journal article)

    Hindley, S., Ward, S. A., Storr, R. C., Searle, N. L., Bray, P. G., Park, B. K., . . . O'Neill, P. M. (2002). Mechanism-based design of parasite-targeted artemisinin derivatives: Synthesis and antimalarial activity of new diamine containing analogues. Journal Of Medicinal Chemistry, 45(5), 1052-1063.

    Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum (Journal article)

    Stocks, P. A., Raynes, K. J., Bray, P. G., Park, B. K., O'Neill, P. M., & Ward, S. A. (2002). Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum. Journal Of Medicinal Chemistry, 45(23), 4975-4983.

    2001

    Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite (Journal article)

    O'Neill, P. M., Scheinmann, F., Stachulski, A. V., Maggs, J. L., & Park, B. K. (2001). Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite. Journal Of Medicinal Chemistry, 44(9), 1467-1470.

    Meta (Journal article)

    Park, B. K., Kitteringham, N. R., & O'Neill, P. M. (2001). Meta. Annual Review Of Pharmacology And Toxicology, 41, 443-470.

    Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin: synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues (Journal article)

    O'Neill, P. M., Pugh, M., Stachulski, A. V., Ward, S. A., Davies, J., & Park, B. K. (2001). Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin: synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues. Journal Of The Chemical Society-Perkin Transactions 1, (20), 2682-2689.

    Regioselective Mukaiyama hydroperoxysilylation of 2-alkyl- or 2-aryl-prop-2-en-1-ols: application to a new synthesis of 1,2,4-trioxanes (Journal article)

    O'Neill, P. M., Pugh, M., Davies, J., Ward, S. A., & Park, B. K. (2001). Regioselective Mukaiyama hydroperoxysilylation of 2-alkyl- or 2-aryl-prop-2-en-1-ols: application to a new synthesis of 1,2,4-trioxanes. Tetrahedron Letters, 42(27), 4569-4571.

    Synthesis, Antimalarial Activity, Biomimetic Iron(II) Chemistry, and in Vivo Metabolism of Novel, Potent C -10-Phenoxy Derivatives of Dihydroartemisinin (Journal article)

    O'Neill, P. M., Miller, A., Bishop, L. P. D., Hindley, S., Maggs, J. L., Ward, S. A., . . . Park, B. K. (2001). Synthesis, Antimalarial Activity, Biomimetic Iron(II) Chemistry, and in Vivo Metabolism of Novel, Potent C -10-Phenoxy Derivatives of Dihydroartemisinin. Journal of Medicinal Chemistry, 44(1), 58-68. doi:10.1021/jm000987f

    DOI: 10.1021/jm000987f

    2000

    4-Aminoquinolines as antimalarials (Patent)

    Raynes, K. J., Ward, S. A., O'Neill, P. M., Stocks, P., & Park, B. K. (2000). 4-Aminoquinolines as antimalarials.

    Biliary metabolites of beta-artemether in rats: Biotransformations of an antimalarial endoperoxide (Journal article)

    Maggs, J. L., Bishop, L. P. D., Edwards, G., O'Neill, P. M., Ward, S. A., Winstanley, P. A., & Park, B. K. (2000). Biliary metabolites of beta-artemether in rats: Biotransformations of an antimalarial endoperoxide. Drug Metabolism And Disposition, 28(2), 209-217.

    Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical (Journal article)

    O'Neill, P. M., Bishop, L. P. D., Searle, N. L., Maggs, J. L., Storr, R. C., Ward, S. A., . . . Mabbs, F. (2000). Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical. Journal Of Organic Chemistry, 65(5), 1578-1582.

    1999

    Application of the TMSOTf-AgClO4 activator system to the synthesis of novel, potent, C-10 phenoxy derivatives of dihydroartemisinin (Journal article)

    O'Neill, P. M., Miller, A., Ward, S. A., Park, B. K., Scheinmann, F., & Stachulski, A. V. (1999). Application of the TMSOTf-AgClO4 activator system to the synthesis of novel, potent, C-10 phenoxy derivatives of dihydroartemisinin. Tetrahedron Letters, 40(51), 9129-9132.

    Asymmetric syntheses of enantiomeric 3-p-fluorophenyl 1,2,4-trioxane analogues of the antimalarial artemisinin (Journal article)

    O'Neill, P. M., Miller, A., Bickley, J. F., Scheinmann, F., Chang, H. O., & Posner, G. H. (1999). Asymmetric syntheses of enantiomeric 3-p-fluorophenyl 1,2,4-trioxane analogues of the antimalarial artemisinin. Tetrahedron Letters, 40(51), 9133-9136.

    Metabolism of the antimalarial endoperoxide Ro 42-1611 (arteflene) in the rat: Evidence for endoperoxide bioactivation (Journal article)

    Bishop, L. P. D., Maggs, J. L., O'Neill, P. M., & Park, B. K. (1999). Metabolism of the antimalarial endoperoxide Ro 42-1611 (arteflene) in the rat: Evidence for endoperoxide bioactivation. Journal Of Pharmacology And Experimental Therapeutics, 289(1), 511-520.

    New 4-aminoquinoline mannich base antimalarials. 1. Effect of an alkyl substituent in the 5 '-position of the 4 '-hydroxyanilino side chain (Journal article)

    Raynes, K. J., Stocks, P. A., O'Neill, P. M., Park, B. K., & Ward, S. A. (1999). New 4-aminoquinoline mannich base antimalarials. 1. Effect of an alkyl substituent in the 5 '-position of the 4 '-hydroxyanilino side chain. Journal Of Medicinal Chemistry, 42(15), 2747-2751.

    Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether (Journal article)

    O'Neill, P. M., Searle, N. L., Kan, K. W., Storr, R. C., Maggs, J. L., Ward, S. A., . . . Park, B. K. (1999). Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether. Journal Of Medicinal Chemistry, 42(26), 5487-5493.

    1998

    4-aminoquinolines - Past, present, and future: A chemical perspective (Journal article)

    O'Neill, P. M., Bray, P. G., Hawley, S. R., Ward, S. A., & Park, B. K. (1998). 4-aminoquinolines - Past, present, and future: A chemical perspective. Pharmacology & Therapeutics, 77(1), 29-58.

    A carbonyl oxide route to antimalarial yingzhaosu A analogues: Synthesis and antimalarial activity (Journal article)

    O'Neill, P. M., Searle, N. L., Raynes, K. J., Maggs, J. L., Ward, S. A., Storr, R. C., . . . Posner, G. H. (1998). A carbonyl oxide route to antimalarial yingzhaosu A analogues: Synthesis and antimalarial activity. Tetrahedron Letters, 39(33), 6065-6068.

    Effect of disposition of Mannich antimalarial agents on their pharmacology and toxicology (Journal article)

    Ruscoe, J. E., Tingle, M. D., O'Neill, P. M., Ward, S. A., & Park, B. K. (1998). Effect of disposition of Mannich antimalarial agents on their pharmacology and toxicology. Antimicrobial Agents And Chemotherapy, 42(9), 2410-2416.

    Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs (Journal article)

    Naisbitt, D. J., Williams, D. P., O'Neill, P. M., Maggs, J. L., Willock, D. J., Pirmohamed, M., & Park, B. K. (1998). Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs. CHEMICAL RESEARCH IN TOXICOLOGY, 11(12), 1586-1595. doi:10.1021/tx980148k

    DOI: 10.1021/tx980148k

    Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro (Journal article)

    Hawley, S. R., Bray, P. G., Mungthin, M., Atkinson, J. D., O'Neill, P. M., & Ward, S. A. (1998). Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro. Antimicrobial Agents And Chemotherapy, 42(3), 682-686.

    Safety assessment of peroxide antimalarials: clinical and chemical perspectives (Journal article)

    Park, B. K., O'Neill, P. M., Maggs, J. L., & Pirmohamed, M. (1998). Safety assessment of peroxide antimalarials: clinical and chemical perspectives. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 46(6), 521-529. doi:10.1046/j.1365-2125.1998.00838.x

    DOI: 10.1046/j.1365-2125.1998.00838.x

    Synthesis of the 8-aminoquinoline antimalarial 5-fluoroprimaquine (Journal article)

    O'Neill, P. M., Storr, R. C., & Park, B. K. (1998). Synthesis of the 8-aminoquinoline antimalarial 5-fluoroprimaquine. Tetrahedron, 54(18), 4615-4622.

    The biliary metabolites of beta-artemether, an endoperoxide antimalarial (Journal article)

    Bell, J. O., Edwards, G., Maggs, J. L., Bishop, L. P., O'Neill, P. M., Ward, S. A., . . . Park, B. K. (1998). The biliary metabolites of beta-artemether, an endoperoxide antimalarial. British Journal Of Pharmacology, 124.

    1997

    Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design (Journal article)

    Naisbitt, D. J., Ruscoe, J. E., Williams, D., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1997). Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 280(2), 884-893. Retrieved from http://gateway.webofknowledge.com/

    Synthesis, Antimalarial Activity, and Molecular Modeling of Tebuquine Analogues (Journal article)

    O'Neill, P. M., Willock, D. J., Hawley, S. R., Bray, P. G., Storr, R. C., Ward, S. A., & Park, B. K. (1997). Synthesis, Antimalarial Activity, and Molecular Modeling of Tebuquine Analogues. Journal of Medicinal Chemistry, 40(4), 437-448. doi:10.1021/jm960370r

    DOI: 10.1021/jm960370r

    The biomimetic iron-mediated degradation of arteflene (Ro-42-1611),an endoperoxide antimalarial: Implications for the mechanism of antimalarial activity (Journal article)

    O'Neill, P. M., Bishop, L. P., Searle, N. L., Maggs, J. L., Ward, S. A., Bray, P. G., . . . Kevin Park, B. (1997). The biomimetic iron-mediated degradation of arteflene (Ro-42-1611),an endoperoxide antimalarial: Implications for the mechanism of antimalarial activity. Tetrahedron Letters, 38(24), 4263-4266. doi:10.1016/S0040-4039(97)00874-5

    DOI: 10.1016/S0040-4039(97)00874-5

    The rat biliary metabolites of dihydroartemisinin, an antimalarial endoperoxide (Journal article)

    Maggs, J. L., Madden, S., Bishop, L. P., ONeill, P. M., & Park, B. K. (1997). The rat biliary metabolites of dihydroartemisinin, an antimalarial endoperoxide. Drug Metabolism and Disposition, 25(10), 1200-1204.

    1996

    Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component (Journal article)

    Hawley, S. R., Bray, P. G., ONeill, P. M., Naisbitt, D. J., Park, B. K., & Ward, S. A. (1996). Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 40(10), 2345-2349. doi:10.1128/AAC.40.10.2345

    DOI: 10.1128/AAC.40.10.2345

    Mechanism-Based Design of Parasite-Targeted Artemisinin Derivatives:  Synthesis and Antimalarial Activity of Benzylamino and Alkylamino Ether Analogues of Artemisinin (Journal article)

    O'Neill, P. M., Bishop, L. P., Storr, R. C., Hawley, S. R., Maggs, J. L., Ward, S. A., & Park, B. K. (1996). Mechanism-Based Design of Parasite-Targeted Artemisinin Derivatives:  Synthesis and Antimalarial Activity of Benzylamino and Alkylamino Ether Analogues of Artemisinin. Journal of Medicinal Chemistry, 39(22), 4511-4514. doi:10.1021/jm9604944

    DOI: 10.1021/jm9604944

    Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity. (Journal article)

    Naisbitt, D. J., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1996). Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 6(13), 1511-1516. doi:10.1016/S0960-894X(96)00260-0

    DOI: 10.1016/S0960-894X(96)00260-0

    The effect of fluorine substitution on the antimalarial activity of tebuquine (Journal article)

    ONeill, P. M., Hawley, S. R., Storr, R. C., Ward, S. A., & Park, B. K. (1996). The effect of fluorine substitution on the antimalarial activity of tebuquine. Bioorganic and Medicinal Chemistry Letters, 6(4), 391-392.

    The role of drug accumulation in 4-aminoquinoline antimalarial potency - The influence of structural substitution and physicochemical properties (Journal article)

    Hawley, S. R., Bray, P. G., ONeill, P. M., Park, B. K., & Ward, S. A. (1996). The role of drug accumulation in 4-aminoquinoline antimalarial potency - The influence of structural substitution and physicochemical properties. Biochemical Pharmacology, 52(5), 723-733.

    1995

    Quinoline Analogues of Ortho-Quinodimethane (Journal article)

    White, L. (1995). Quinoline Analogues of Ortho-Quinodimethane. Tetrahedron Letters, 36(33), 5983-5986. doi:10.1016/00404-0399(50)1159F-

    DOI: 10.1016/00404-0399(50)1159F-

    Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine (Journal article)

    Jewell, H., Maggs, J. L., Harrison, A. C., O'neill, P. M., Ruscoe, J. E., & Park, B. K. (1995). Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine. Xenobiotica, 25(2), 199-217. doi:10.3109/00498259509061845

    DOI: 10.3109/00498259509061845

    THE EFFECT OF CHEMICAL SUBSTITUTION ON THE METABOLIC-ACTIVATION, METABOLIC DETOXICATION, AND PHARMACOLOGICAL ACTIVITY OF AMODIAQUINE IN THE MOUSE (Journal article)

    RUSCOE, J. E., JEWELL, H., MAGGS, J. L., ONEILL, P. M., STORR, R. C., WARD, S. A., & PARK, B. K. (1995). THE EFFECT OF CHEMICAL SUBSTITUTION ON THE METABOLIC-ACTIVATION, METABOLIC DETOXICATION, AND PHARMACOLOGICAL ACTIVITY OF AMODIAQUINE IN THE MOUSE. Journal of Pharmacology and Experimental Therapeutics, 273(1), 393-404.

    THE EFFECT OF FLUORINE SUBSTITUTION ON THE HAEMOTOXICITY OF PRIMAQUINE (Journal article)

    ONEILL, P. M., TINGLE, M. D., MAHMUD, R., STORR, R. C., WARD, S. A., & PARK, B. K. (1995). THE EFFECT OF FLUORINE SUBSTITUTION ON THE HAEMOTOXICITY OF PRIMAQUINE. Bioorganic and Medicinal Chemistry Letters, 5(20), 2309-2314.

    The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: Chemical mechanisms and the effects of fluorine substitution (Journal article)

    Tingle, M., Jewell, H., Maggs, J., O'Neill, P., & Park, B. (1995). The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: Chemical mechanisms and the effects of fluorine substitution. Biochemical Pharmacology, 50(7), 1113-1119. doi:10.1016/0006-2952(95)00236-S

    DOI: 10.1016/0006-2952(95)00236-S

    1994

    The Effect of Fluorine Substitution on the Metabolism and Antimalarial Activity of Amodiaquine (Journal article)

    O'Neill, P. M., Harrison, A. C., Storr, R. C., Hawley, S. R., Ward, S. A., & Park, B. K. (1994). The Effect of Fluorine Substitution on the Metabolism and Antimalarial Activity of Amodiaquine. Journal of Medicinal Chemistry, 37(9), 1362-1370. doi:10.1021/jm00035a017

    DOI: 10.1021/jm00035a017

    1993

    2-Methyl-5,6-dimethylenepyrimidin-4-one: A Novel Diene (Journal article)

    Tomé, A. C., O'Neill, P. M., Storr, R. C., & Cavaleiro, J. A. S. (1993). 2-Methyl-5,6-dimethylenepyrimidin-4-one: A Novel Diene. Synlett, 1993(05), 347-348. doi:10.1055/s-1993-22450

    DOI: 10.1055/s-1993-22450

    The Effect of Fluorine Substitution on the Physicochemical Properties and the Analgesic Activity of Paracetamol (Journal article)

    BARNARD, S., STORR, R. C., O'NEILL, P. M., & PARK, B. K. (1993). The Effect of Fluorine Substitution on the Physicochemical Properties and the Analgesic Activity of Paracetamol. Journal of Pharmacy and Pharmacology, 45(8), 736-744. doi:10.1111/j.2042-7158.1993.tb07099.x

    DOI: 10.1111/j.2042-7158.1993.tb07099.x

    1992

    Heterocyclic fused 2,5-dihydrothiophene S,S-dioxides as precursors to heterocyclic o-quinodimethanes (Journal article)

    Chaloner, L. M., Crew, A. P., O'Neill, P. M., Storr, R. C., & Yelland, M. (1992). Heterocyclic fused 2,5-dihydrothiophene S,S-dioxides as precursors to heterocyclic o-quinodimethanes. Tetrahedron, 48(37), 8101-8116. doi:10.1016/S0040-4020(01)80480-4

    DOI: 10.1016/S0040-4020(01)80480-4

    Untitled Document