Photo of Professor Paul O'Neill

Professor Paul O'Neill BSc Hons PhD CChem MRSC

Professor Chemistry


    Selected Publications

    1. AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis (Journal article - 2019)
    2. A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance (Journal article - 2017)
    3. Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7 (Journal article - 2016)
    4. Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides (Journal article - 2019)
    5. A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile (Journal article - 2016)
    6. Antimalarial activity of primaquine operates via a two-step biochemical relay (Journal article - 2019)
    7. Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2? (Journal article - 2021)
    8. Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives (Journal article - 2021)
    9. Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid (Journal article - 2021)
    10. Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205 (Journal article - 2021)