2017 - Centre for Drug Safety Science - University of Liverpool

17q21 Gene Variance Increases The Risk Of Exacerbations In Asthmatic Children Treated With Inhaled Corticosteroids: A Meta-Analysis In The Pica Consortium

(Conference Paper)

Farzan, N., Vijverberg, S., Hernandez-Pacheco, N., Berce, V., Burchard, E. G., Canino, G., . . . Maitland-van Der Zee, A. -H. (2017). 17q21 Gene Variance Increases The Risk Of Exacerbations In Asthmatic Children Treated With Inhaled Corticosteroids: A Meta-Analysis In The Pica Consortium. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 195.

A common missense variant of LILRB5 is associated with statin intolerance and myalgia.

(Journal article)

Siddiqui, M. K., Maroteau, C., Veluchamy, A., Tornio, A., Tavendale, R., Carr, F., . . . Consortium, P. R. E. D. I. C. T. I. O. N. -A. D. R. (2017). A common missense variant of LILRB5 is associated with statin intolerance and myalgia. EUROPEAN HEART JOURNAL, 38(48), 3569-3U31. DOI: 10.1093/eurheartj/ehx467

A prospective cohort study examining the effectiveness of baclofen in the maintenance of abstinence in alcohol use disorder patients attending a joint liver and alcohol treatment clinic

(Journal article)

Owens, L., Thompson, A., Rose, A., Gilmore, I., Pirmohamed, M., & Richardson, P. (2017). A prospective cohort study examining the effectiveness of baclofen in the maintenance of abstinence in alcohol use disorder patients attending a joint liver and alcohol treatment clinic. ALCOHOL, 62, 11-15. DOI: 10.1016/j.alcohol.2016.12.005

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

(Journal article)

O'Neill, P. M., Amewu, R. K., Charman, S. A., Sabbani, S., Gnadig, N. F., Straimer, J., . . . Ward, S. A. (2017). A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance. NATURE COMMUNICATIONS, 8. DOI: 10.1038/ncomms15159

Adverse Drug Reaction Causality Assessment Tools For Drug-Induced Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis: Room For Improvement

(Conference Paper)

Goldman, J. L., Chung, W. -H., Lee, B., Hoetzenecker, W., Micheletti, R. G., Yasuda, S. U., . . . Pirmohamed, M. (2017). ADVERSE DRUG REACTION CAUSALITY ASSESSMENT TOOLS FOR DRUG-INDUCED STEVENS-JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS: ROOM FOR IMPROVEMENT.. In CLINICAL PHARMACOLOGY & THERAPEUTICS Vol. 101 (pp. S30).

Age-stratified outcome of a genotype-guided dosing algorithm for acenocoumarol and phenprocoumon

(Journal article)

Zhang, Y., de Boer, A., Verhoef, T. I., van der Meer, F. J. M., Le Cessie, S., Manolopoulos, V. G., . . . Grp, E. U. -P. A. C. T. (2017). Age-stratified outcome of a genotype-guided dosing algorithm for acenocoumarol and phenprocoumon. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 15(3), 454-464. DOI: 10.1111/jth.13601

An assessment of the impact of pharmacogenomics on health disparities: a systematic literature review

(Journal article)

Martin, A., Downing, J., Maden, M., Fleeman, N., Alfirevic, A., Haycox, A., & Pirmohamed, M. (2017). An assessment of the impact of pharmacogenomics on health disparities: a systematic literature review. PHARMACOGENOMICS, 18(16), 1541-1550. DOI: 10.2217/pgs-2017-0076

An evaluation of in vitro models for the assessment of mitochondrial toxicity within Drug Induced Liver Injury (DILI)

(Thesis/Dissertation)

Douglas, O. (2017). An evaluation of in vitro models for the assessment of mitochondrial toxicity within Drug Induced Liver Injury (DILI). (University of Liverpool).

Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts

(Journal article)

Amali, M. O., Jenkins, R. E., Meng, X., Faulkner, L., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2017). Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2097-2099. DOI: 10.1021/acs.chemrestox.7b00291

Assessment of gene expression profiles of peripheral blood mononuclear cells from patients with a history of carbamazepine hypersensitivity

(Conference Paper)

Yip, V., Zhang, E., Clarke, K., Francis, B., Rainbow, L., Falciani, F., . . . Pirmohamed, M. (2017). Assessment of gene expression profiles of peripheral blood mononuclear cells from patients with a history of carbamazepine hypersensitivity. In LANCET Vol. 389 (pp. 104).

Beyond co-occurrence-based ADR detection from Social Media

(Poster)

Bollegala, D., Maskell, S., & Pirmohamed, M. (2017). Beyond co-occurrence-based ADR detection from Social Media. Poster session presented at the meeting of Unknown Conference.

Bioenergetic profile of human coronary artery smooth muscle cells and effect of metabolic intervention

(Journal article)

Yang, M., Chadwick, A. E., Dart, C., Kamishima, T., & Quayle, J. M. (2017). Bioenergetic profile of human coronary artery smooth muscle cells and effect of metabolic intervention. PLOS ONE, 12(5). DOI: 10.1371/journal.pone.0177951

CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia

(Journal article)

Siddiqui, M. K., Veluchamy, A., Maroteau, C., Tavendale, R., Carr, F., Pearson, E., . . . Consortium, P. R. E. D. I. C. T. I. O. N. -A. D. R. (2017). CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia. CIRCULATION-CARDIOVASCULAR GENETICS, 10(4). DOI: 10.1161/CIRCGENETICS.117.001737

Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells

(Journal article)

Ogese, M. O., Faulkner, L., Jenkins, R. E., French, N. S., Copple, I. M., Antoine, D. J., . . . Naisbitt, D. J. (2017). Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells. TOXICOLOGICAL SCIENCES, 158(1), 76-89. DOI: 10.1093/toxsci/kfx069

Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury

(Journal article)

Usui, T., Meng, X., Saide, K., Farrell, J., Thomson, P., Whitaker, P., . . . Naisbitt, D. J. (2017). Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury. TOXICOLOGICAL SCIENCES, 155(2), 420-431. DOI: 10.1093/toxsci/kfw218

Circulating levels of miR-122 increase post-mortem, particularly following lethal dosing with pentobarbital sodium: implications for pre-clinical liver injury studies

(Journal article)

Clarke, J. I., Forootan, S. S., Lea, J. D., Howell, L. S., Rodriguez, J. M., Kipar, A., . . . Antoine, D. J. (2017). Circulating levels of miR-122 increase post-mortem, particularly following lethal dosing with pentobarbital sodium: implications for pre-clinical liver injury studies. TOXICOLOGY RESEARCH, 6(4), 406-411. DOI: 10.1039/c6tx00442c

Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use

(Journal article)

Parsons, B. N., Ijaz, U. Z., D'Amore, R., Burkitt, M. D., Eccles, R., Lenzi, L., . . . Pritchard, D. M. (2017). Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use. PLOS PATHOGENS, 13(11). DOI: 10.1371/journal.ppat.1006653

Cost-Effectiveness Of A Multi -Gene Panel In The Context Of Reducing Adverse Drug Reactions

(Conference Paper)

Plumpton, C. O., Pirmohamed, M., & Hughes, D. A. (2017). COST-EFFECTIVENESS OF A MULTI -GENE PANEL IN THE CONTEXT OF REDUCING ADVERSE DRUG REACTIONS. In VALUE IN HEALTH Vol. 20 (pp. A753).

Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout

(Journal article)

Plumpton, C. O., Alfirevic, A., Pirmohamed, M., & Hughes, D. A. (2017). Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout. RHEUMATOLOGY, 56(10), 1729-1739. DOI: 10.1093/rheumatology/kex253

Checkpoint Inhibitor induced thyroid immune related adverse events: two distinct clinical patterns

(Conference Paper)

Olsson-Brown, A., Lord, R., Sacco, J., Upton, J., Coles, M., & Pirmohamed, M. (2017). Checkpoint Inhibitor induced thyroid immune related adverse events: two distinct clinical patterns. In DRUG SAFETY Vol. 40 (pp. 1034).

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update.

(Journal article)

Johnson, J. A., Caudle, K. E., Gong, L., Whirl-Carrillo, M., Stein, C. M., Scott, S. A., . . . Wadelius, M. (2017). Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update. CLINICAL PHARMACOLOGY & THERAPEUTICS, 102(3), 397-404. DOI: 10.1002/cpt.668

Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout.

(Journal article)

Defining mechanisms of co inhibitory receptor Lymphocyte Activation Gene-3 (LAG-3) in T cells

(Thesis/Dissertation)

Alhumeed, N. A. (2017, March 1). Defining mechanisms of co inhibitory receptor Lymphocyte Activation Gene-3 (LAG-3) in T cells.

Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors

(Journal article)

Alzahrani, A., Ogese, M., Meng, X., Waddington, J. C., Tailor, A., Farrell, J., . . . Naisbitt, D. (2017). Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2174-2186. DOI: 10.1021/acs.chemrestox.7b00263

Definition of the Nature and Hapten Threshold of the beta-Lactam Antigen Required for T Cell Activation In Vitro and in Patients

(Journal article)

Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2017). Definition of the Nature and Hapten Threshold of the beta-Lactam Antigen Required for T Cell Activation In Vitro and in Patients. JOURNAL OF IMMUNOLOGY, 198(11), 4217-4227. DOI: 10.4049/jimmunol.1700209

Development of ELISAs for diagnosis of acute typhoid fever in Nigerian children

(Journal article)

Felgner, J., Jain, A., Nakajima, R., Liang, L., Jasinskas, A., Gotuzzo, E., . . . Davies, D. H. (2017). Development of ELISAs for diagnosis of acute typhoid fever in Nigerian children. PLOS NEGLECTED TROPICAL DISEASES, 11(6). DOI: 10.1371/journal.pntd.0005679

Development of the Liverpool Adverse Drug Reaction Avoidability Assessment Tool

(Journal article)

Bracken, L. E., Nunn, A. J., Kirkham, J. J., Peak, M., Arnott, J., Smyth, R. L., . . . Turner, M. A. (2017). Development of the Liverpool Adverse Drug Reaction Avoidability Assessment Tool. PLOS ONE, 12(1). DOI: 10.1371/journal.pone.0169393

Development, validation and clinical application of a method for the simultaneous quantification of lamivudine, emtricitabine and tenofovir in dried blood and dried breast milk spots using LC-MS/MS

(Journal article)

Waitt, C., Penchala, S. D., Olagunju, A., Amara, A., Else, L., Lamorde, M., & Khoo, S. (2017). Development, validation and clinical application of a method for the simultaneous quantification of lamivudine, emtricitabine and tenofovir in dried blood and dried breast milk spots using LC-MS/MS. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1060, 300-307. DOI: 10.1016/j.jchromb.2017.06.012

Donor-Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells

(Journal article)

Heslop, J. A., Kia, R., Pridgeon, C. S., Sison-Young, R. L., Liloglou, T., Elmasry, M., . . . Park, B. K. (2017). Donor-Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells. STEM CELLS TRANSLATIONAL MEDICINE, 6(5), 1321-1331. DOI: 10.1002/sctm.16-0029

Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo

(Journal article)

Brillant, N., Elmasry, M., Burton, N. C., Rodriguez, J. M., Sharkey, J. W., Fenwick, S., . . . Antoine, D. J. (2017). Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo. TOXICOLOGY AND APPLIED PHARMACOLOGY, 332, 64-74. DOI: 10.1016/j.taap.2017.07.019

Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development

(Chapter)

Goldring, C., Weaver, R., Kramer, B., Klingmueller, U., Oppelt, A., Van der Water, B., . . . Kevin Park, B. (2017). Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development. In Comprehensive Medicinal Chemistry III (Vol. 4-8, pp. 217-238). DOI: 10.1016/B978-0-12-409547-2.12384-4

Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalink study

(Journal article)

Thompson, A., Ashcroft, D. M., Owens, L., van Staa, T. P., & Pirmohamed, M. (2017). Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalink study. PLOS ONE, 12(3). DOI: 10.1371/journal.pone.0173272

Evaluation of agreement of placental growth factor (PlGF) tests and the soluble FMS-like tyrosine kinase 1 (sFlt-1)/PlGF ratio, comparison of predictive accuracy for pre-eclampsia, and relation to uterine artery Doppler and response to aspirin.

(Journal article)

Navaratnam, K., Abreu, P., Clarke, H., Jorgensen, A., Alfirevic, A., & Alfirevic, Z. (2017). Evaluation of agreement of placental growth factor (PlGF) tests and the soluble FMS-like tyrosine kinase 1 (sFlt-1)/PlGF ratio, comparison of predictive accuracy for pre-eclampsia, and relation to uterine artery Doppler and response to aspirin.. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 1-9. DOI: 10.1080/14767058.2017.1373760

Examination Of Equity In The Delivery Of Personalised Medicines

(Conference Paper)

Martin, A. P., Haycox, A., Downing, J., Alfirevic, A., & Pirmohamed, M. (2016). EXAMINATION OF EQUITY IN THE DELIVERY OF PERSONALISED MEDICINES. In VALUE IN HEALTH Vol. 19 (pp. A266). doi:10.1016/j.jval.2016.03.771

Exome sequencing of synchronously resected primary colorectal tumours and colorectal liver metastases to inform oncosurgical management

(Journal article)

Sutton, P. A., Jithesh, P. V., Jones, R. P., Evans, J. P., Vimalachandran, D., Malik, H. Z., . . . Kitteringham, N. R. (2018). Exome sequencing of synchronously resected primary colorectal tumours and colorectal liver metastases to inform oncosurgical management. EJSO, 44(1), 115-121. DOI: 10.1016/j.ejso.2017.10.211

Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response

(Journal article)

Zhang, J. E., Klein, K., Jorgensen, A. L., Francis, B., Alfirevic, A., Bourgeois, S., . . . Pirmohamed, M. (2017). Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response. FRONTIERS IN PHARMACOLOGY, 8. DOI: 10.3389/fphar.2017.00323

Epidemiology of alcohol dependence in UK primary care: Results from a large observational study using the Clinical Practice Research Datalink

(Journal article)

Thompson, A., Wright, A. K., Ashcroft, D. M., van Staa, T. P., & Pirmohamed, M. (2017). Epidemiology of alcohol dependence in UK primary care: Results from a large observational study using the Clinical Practice Research Datalink. PLOS ONE, 12(3). DOI: 10.1371/journal.pone.0174818

Estimating the Pertinent Information Present in Social Media, not just what an Algorithm Detects

(Poster)

Maskell, S., Sloane, R., Perkins, S., Heap, J., Hajne, J., Jones, A., & Pirmohamed, M. (2017). Estimating the Pertinent Information Present in Social Media, not just what an Algorithm Detects. Poster session presented at the meeting of Unknown Conference.

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Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo

(Journal article)

Sharkey, J., Lewis, P. J. S., Barrow, M., Alwahsh, S. M., Noble, J., Livingstone, E., . . . Park, B. K. (2017). Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo. CYTOTHERAPY, 19(4), 555-569. DOI: 10.1016/j.jcyt.2017.01.003

Generation of a novel, personalised in vitro model to assess the impact of mitochondrial DNA variation upon susceptibility to hepatotoxicity

(Conference Paper)

Ball, A., Alfirevic, A., Lyon, J., & Chadwick, A. (2017). Generation of a novel, personalised in vitro model to assess the impact of mitochondrial DNA variation upon susceptibility to hepatotoxicity. In DRUG SAFETY Vol. 40 (pp. 1024-1025).

Genetic regulation of gene expression in the epileptic human hippocampus

(Journal article)

Mirza, N., Appleton, R., Burn, S., du Plessis, D., Duncan, R., Farah, J. O., . . . Pirmohamed, M. (2017). Genetic regulation of gene expression in the epileptic human hippocampus. HUMAN MOLECULAR GENETICS, 26(9), 1759-1769. DOI: 10.1093/hmg/ddx061

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients

(Journal article)

McCormack, M., Gui, H., Ingason, A., Speed, D., Wright, G. E. B., Zhang, E. J., . . . Consortium, I. L. E. (2018). Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients. NEUROLOGY, 90(4), E332-+. DOI: 10.1212/WNL.0000000000004853

Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population

(Journal article)

Carr, D. F., Bourgeois, S., Chaponda, M., Takeshita, L. Y., Morris, A. P., Castro, E. M. C., . . . Pirmohamed, M. (2017). Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 72(4), 1152-1162. DOI: 10.1093/jac/dkw545

Genomics of Adverse Drug Reactions

(Journal article)

Alfirevic, A., & Pirmohamed, M. (2017). Genomics of Adverse Drug Reactions. TRENDS IN PHARMACOLOGICAL SCIENCES, 38(1), 100-109. DOI: 10.1016/j.tips.2016.11.003

HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study.

(Journal article)

Bluett, J., Owen, S. -A., Massey, J., Alfirevic, A., Pirmohamed, M., Plant, D., . . . Consortium, P. S. (2017). HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study. ANNALS OF THE RHEUMATIC DISEASES, 76(12). DOI: 10.1136/annrheumdis-2017-211512

Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models

(Journal article)

Burkitt, M. D., Duckworth, C. A., Williams, J. M., & Pritchard, D. M. (2017). Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models. DISEASE MODELS & MECHANISMS, 10(2), 89-104. DOI: 10.1242/dmm.027649

How important is aspirin adherence when evaluating effectiveness of low-dose aspirin?

(Journal article)

Navaratnam, K., Alfirevic, Z., Pirmohamed, M., & Alfirevic, A. (2017). How important is aspirin adherence when evaluating effectiveness of low-dose aspirin?. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 219, 1-9. DOI: 10.1016/j.ejogrb.2017.10.004

Human leucocyte antigen-adverse drug reaction associations: from a perspective of ethnicity

(Journal article)

Ghattaoraya, G. S., Middleton, D., Santos, E. J. M., Dickson, R., Jones, A. R., & Alfirevic, A. (2017). Human leucocyte antigen-adverse drug reaction associations: from a perspective of ethnicity. INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 44(1), 7-26. DOI: 10.1111/iji.12304

Identification of drug-and drug-metabolite immune responses originating from both naive and memory T cells

(Journal article)

Gibson, A., Faulkner, L., Wood, S., Park, B. K., & Naisbitt, D. J. (2017). Identification of drug-and drug-metabolite immune responses originating from both naive and memory T cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140(2), 578-+. DOI: 10.1016/j.jaci.2016.11.032

Identifying cisplatin-induced kidney damage in paediatric oncology patients.

(Journal article)

Barton, C. D., Pizer, B., Jones, C., Oni, L., Pirmohamed, M., & Hawcutt, D. B. (2018). Identifying cisplatin-induced kidney damage in paediatric oncology patients.. Pediatric nephrology (Berlin, Germany), 33(9), 1467-1474. DOI: 10.1007/s00467-017-3765-6

Identifying new antiepileptic drugs through genomics-based drug repurposing

(Journal article)

Mirza, N., Sills, G. J., Pirmohamed, M., & Marson, A. G. (2017). Identifying new antiepileptic drugs through genomics-based drug repurposing. HUMAN MOLECULAR GENETICS, 26(3), 527-537. DOI: 10.1093/hmg/ddw410

Impact of Clostridium difficile infection: clinical and economic perspectives

(Thesis/Dissertation)

Nakamura, C. A. (2017, October 13). Impact of Clostridium difficile infection: clinical and economic perspectives.

Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium (vol 101, pg 341, 2017)

(Journal article)

van der Wouden, C. H., Cambon-Thomsen, A., Cecchin, E., Cheung, K. C., Davila-Fajardo, C. L., Deneer, V. H., . . . Pharmacogenomics, U. (2017). Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium (vol 101, pg 341, 2017). CLINICAL PHARMACOLOGY & THERAPEUTICS, 102(1), 152. DOI: 10.1002/cpt.725

Investigation of the importance of intestinal epithelial cell specific nuclear factor-κB subunits in regulating the response to intestinal damage-inducing stimuli

(Thesis/Dissertation)

James, S. (2017, October 30). Investigation of the importance of intestinal epithelial cell specific nuclear factor-κB subunits in regulating the response to intestinal damage-inducing stimuli.

In silico prediction of skin metabolism and its implication in toxicity assessment

(Journal article)

Madden, J., Webb, S., Enoch, S., Colley, H., Murdoch, C., Shipley, R., . . . Cronin, M. (2017). In silico prediction of skin metabolism and its implication in toxicity assessment. Computational Toxicology, 3, 44-57. DOI: 10.1016/j.comtox.2017.07.001

In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line

(Journal article)

Curley, P., Giardiello, M., Liptrott, N. J., Dickens, D., Moss, D. M., Hobson, J. J., . . . Owen, A. (2017). In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line. Journal of Interdisciplinary Nanomedicine, 2(3), 157-169. DOI: 10.1002/jin2.32

Kinetic characterization of bile salt transport by human NTCP (SLC10A1)

(Journal article)

Jani, M., Beery, E., Heslop, T., Toth, B., Jagota, B., Kis, E., . . . Weaver, R. J. (2018). Kinetic characterization of bile salt transport by human NTCP (SLC10A1). TOXICOLOGY IN VITRO, 46, 189-193. DOI: 10.1016/j.tiv.2017.10.012

Looking Longitudinally in Twitter: Reading More than 140 Characters

(Poster)

Maskell, S., Sloane, R., Hajne, J., Heap, J., Perkins, S., Griffith, E., . . . Pirmohamed, M. (2017). Looking Longitudinally in Twitter: Reading More than 140 Characters. Poster session presented at the meeting of Unknown Conference.

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients.

(Journal article)

Yip, V. L. M., Meng, X., Maggs, J. L., Jenkins, R. E., Marlot, P. T., Marson, A. G., . . . Pirmohamed, M. (2017). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 30(7), 1419-1435. DOI: 10.1021/acs.chemrestox.7b00063

Mechanisms of Chemotherapy-Induced Diarrhoea

(Conference Paper)

French, S., Davies, A., & Pirmohamed, M. (2017). Mechanisms of Chemotherapy-Induced Diarrhoea. In DRUG SAFETY Vol. 40 (pp. 1025-1026).

Mechanistic biomarkers stratify patients after paracetamol overdose with high sensitivity and specificity

(Conference Paper)

Dear, J. W., Clarke, J. I., Francis, B., Philips, L., Wraight, J., Dargan, P. I., . . . Antoine, D. J. (2017). Mechanistic biomarkers stratify patients after paracetamol overdose with high sensitivity and specificity. In CLINICAL TOXICOLOGY Vol. 55 (pp. 468).

Mice lacking NF-kappa B1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration

(Journal article)

Burkitt, M. D., Williams, J. M., Townsend, T., Hough, R., & Pritchard, D. M. (2017). Mice lacking NF-kappa B1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration. CELL DEATH & DISEASE, 8. DOI: 10.1038/cddis.2017.332

Micrometer scale guidance of mesenchymal stem cells to form structurally oriented large-scale tissue engineered cartilage

(Journal article)

Chou, C. -L., Rivera, A. L., Williams, V., Welter, J. F., Mansour, J. M., Drazba, J. A., . . . Baskaran, H. (2017). Micrometer scale guidance of mesenchymal stem cells to form structurally oriented large-scale tissue engineered cartilage. ACTA BIOMATERIALIA, 60, 210-219. DOI: 10.1016/j.actbio.2017.07.016

MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury.

(Journal article)

Howell, L. S., Ireland, L., Park, B. K., & Goldring, C. E. (2018). MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 18(1), 47-54. DOI: 10.1080/14737159.2018.1415145

Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol

(Journal article)

Dickens, D., Chiduza, G. N., Wright, G. S. A., Pirmohamed, M., Antonyuk, S. V., & Hasnain, S. S. (2017). Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol. SCIENTIFIC REPORTS, 7. DOI: 10.1038/srep43580

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

(Journal article)

Walker, L. E., Frigerio, F., Ravizza, T., Ricci, E., Tse, K., Jenkins, R. E., . . . Pirmohamed, M. (2017). Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy. JOURNAL OF CLINICAL INVESTIGATION, 127(6), 2118-2132. DOI: 10.1172/JCI92001

Multiple HLA B*57 alleles, sharing the amino acid residue Valine(97), are associated with drug-induced liver injury due to flucloxacillin in a European population.

(Conference Paper)

Nicoletti, P., Aithal, G. P., Coulthard, S., Andrade, R., Einar, B. S., Dillon, J., . . . Daly, A. K. (2017). Multiple HLA B*57 alleles, sharing the amino acid residue Valine(97), are associated with drug-induced liver injury due to flucloxacillin in a European population.. In HEPATOLOGY Vol. 66 (pp. 25A-26A).

Nilotinib-Induced Metabolic Dysfunction: Insights From A Translational Pilot Study Using In Vitro Adipocyte Models And Patient Cohorts

(Poster)

Sadiq, S., Owen, E., Foster, T., Knight, K., Wang, L., Pirmohamed, M., . . . Pushpakom, S. (2017). NILOTINIB-INDUCED METABOLIC DYSFUNCTION: INSIGHTS FROM A TRANSLATIONAL PILOT STUDY USING IN VITRO ADIPOCYTE MODELS AND PATIENT COHORTS. Poster session presented at the meeting of Unknown Conference.

New Approaches to Investigate Drug-Induced Hypersensitivity

(Journal article)

Ogese, M. O., Ahmed, S., Alferivic, A., Betts, C. J., Dickinson, A., Faulkner, L., . . . Naisbitt, D. J. (2017). New Approaches to Investigate Drug-Induced Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 30(1), 239-259. DOI: 10.1021/acs.chemrestox.6b00333

Non-Medical Prescriber Experiences of Training and Competence to Report Adverse Drug Reactions

(Conference Paper)

Thompson, A., Randall, C., Howard, J., & Pirmohamed, M. (2017). Non-Medical Prescriber Experiences of Training and Competence to Report Adverse Drug Reactions. In DRUG SAFETY Vol. 40 (pp. 1002).

NRF2 as an Emerging Therapeutic Target

(Journal article)

Copple, I. M., Dinkova-Kostova, A. T., Kensler, T. W., Liby, K. T., & Wigley, W. C. (2017). NRF2 as an Emerging Therapeutic Target. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. DOI: 10.1155/2017/8165458

Optimising the use of medicines to reduce acute kidney injury in children and babies

(Journal article)

Oni, L., Hawcutt, D. B., Turner, M. A., Beresford, M. W., McWilliam, S., Barton, C., . . . Antoine, D. J. (2017). Optimising the use of medicines to reduce acute kidney injury in children and babies. PHARMACOLOGY & THERAPEUTICS, 174, 55-62. DOI: 10.1016/j.pharmthera.2017.02.018

Patient ethnicity and the risk of immune-mediated adverse drug reactions

(Journal article)

Alfirevic, A. (2017). Patient ethnicity and the risk of immune-mediated adverse drug reactions. PHARMACOGENOMICS, 18(15), 1375-1378. DOI: 10.2217/pgs-2017-0124

Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins

(Journal article)

Rowe, C., Shaeri, M., Large, E., Cornforth, T., Robinson, A., Kostrzewski, T., . . . Hughes, D. (2018). Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins. TOXICOLOGY IN VITRO, 46, 29-38. DOI: 10.1016/j.tiv.2017.09.012

Pharmacogenomics: Relevance To Personalized Medicine

(Conference Paper)

Pirmohamed, M. (2017). PHARMACOGENOMICS: RELEVANCE TO PERSONALIZED MEDICINE. In DRUG METABOLISM AND PHARMACOKINETICS Vol. 32 (pp. S10).

Pharmacogenetics for the prescriber

(Journal article)

Pirmohamed, M. (2016). Pharmacogenetics for the prescriber. Medicine, 44(7), 412-415. DOI: 10.1016/j.mpmed.2016.04.010

Platelet function and response to low-dose aspirin in pregnancy

(Thesis/Dissertation)

Navaratnam, K. (2017). Platelet function and response to low-dose aspirin in pregnancy. (University of Liverpool).

Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies.

(Journal article)

Scarfe, L., Brillant, N., Kumar, J. D., Ali, N., Alrumayh, A., Amali, M., . . . Park, B. K. (2017). Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies.. NPJ Regenerative medicine, 2, 28. DOI: 10.1038/s41536-017-0029-9

Preventing aminoglycoside-induced nephrotoxicity using statins: an example of bench-to-bedside research

(Conference Paper)

McWilliam, S. J., Antoine, D., Smyth, R., & Pirmohamed, M. (2017). Preventing aminoglycoside-induced nephrotoxicity using statins: an example of bench-to-bedside research. In Archives of Disease in Childhood Vol. 102 (pp. A12). Leuven: BMJ.

Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways

(Journal article)

Brandi, J., Dando, I., Dalla Pozza, E., Biondani, G., Jenkins, R., Elliott, V., . . . Palmieri, M. (2017). Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways. JOURNAL OF PROTEOMICS, 150, 310-322. DOI: 10.1016/j.jprot.2016.10.002

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

(Journal article)

Farzan, N., Vijverberg, S. J., Andiappan, A. K., Arianto, L., Berce, V., Blanca-Lopez, N., . . . Maitland-van der Zee, A. H. (2017). Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium. PHARMACOGENOMICS, 18(10), 931-943. DOI: 10.2217/pgs-2017-0035

RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells

(Journal article)

Alghanem, A. F., Wilkinson, E. L., Emmett, M. S., Aljasir, M. A., Holmes, K., Rothermel, B. A., . . . Cross, M. J. (2017). RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells. ANGIOGENESIS, 20(3), 341-358. DOI: 10.1007/s10456-017-9542-0

Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity

(Journal article)

Forootan, S. S., Mutter, F. E., Kipar, A., Iwawaki, T., Francis, B., Goldring, C. E., . . . Copple, I. M. (2017). Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity. SCIENTIFIC REPORTS, 7. DOI: 10.1038/s41598-017-16491-2

Renal function monitoring in heart failure - what is the optimal frequency? A narrative review

(Journal article)

Al-Naher, A., Wright, D., Devonald, M. A. J., & Pirmohamed, M. (2018). Renal function monitoring in heart failure - what is the optimal frequency? A narrative review. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 84(1), 5-17. DOI: 10.1111/bcp.13434

Repurposing Statins for Renal Protection: Is It a Class Effect?

(Journal article)

McWilliam, S. J., Antoine, D. J., & Pirmohamed, M. (2018). Repurposing Statins for Renal Protection: Is It a Class Effect?. CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 11(2), 100-102. DOI: 10.1111/cts.12521

Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis

(Journal article)

Manolio, T. A., Hutter, C. M., Avigan, M., Cibotti, R., Davis, R. L., Denny, J. C., . . . Shear, N. H. (2018). Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis. CLINICAL PHARMACOLOGY & THERAPEUTICS, 103(3), 390-394. DOI: 10.1002/cpt.890

Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies.

(Journal article)

Dear, J. W., Clarke, J. I., Francis, B., Allen, L., Wraight, J., Shen, J., . . . Antoine, D. J. (2018). Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies.. The lancet. Gastroenterology & hepatology, 3(2), 104-113. DOI: 10.1016/s2468-1253(17)30266-2

SPIONs for cell labelling and tracking using MRI: magnetite or maghemite?

(Journal article)

Barrow, M., Taylor, A., Fuentes-Caparros, A. M., Sharkey, J., Daniels, L. M., Mandal, P., . . . Adams, D. J. (2017). SPIONs for cell labelling and tracking using MRI: magnetite or maghemite?. BIOMATERIALS SCIENCE, 6(1), 101-106. DOI: 10.1039/c7bm00515f

State-of-the-Art and New Options to Assess T Cell Activation by Skin Sensitizers: Cosmetics Europe Workshop

(Journal article)

van Vliet, E., Kuehnl, J., Goebel, C., Martinozzi-Teissier, S., Alepee, N., Ashikaga, T., . . . Petersohn, D. (2018). State-of-the-Art and New Options to Assess T Cell Activation by Skin Sensitizers: Cosmetics Europe Workshop. ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 35(2), 179-192. DOI: 10.14573/altex.1709011

Statin-induced mytotoxicity

(Conference Paper)

Pirmohamed, M. (2017). STATIN-INDUCED MYTOTOXICITY. In DRUG METABOLISM AND PHARMACOKINETICS Vol. 32 (pp. S10).

Statin-associated muscle toxicity: clinical and genomic perspectives

(Thesis/Dissertation)

Turner, R. (2017, December 15). Statin-associated muscle toxicity: clinical and genomic perspectives.

Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells

(Journal article)

Wilkinson, E. L., Sidaway, J. E., & Cross, M. J. (2018). Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells. JOURNAL OF CELLULAR PHYSIOLOGY, 233(1), 186-200. DOI: 10.1002/jcp.26064

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Standard Reporting and Evaluation Guidelines: Results of a National Institutes of Health Working Group.

(Journal article)

Maverakis, E., Wang, E. A., Shinkai, K., Mahasirimongkol, S., Margolis, D. J., Avigan, M., . . . Cheng, M. Y. (2017). Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Standard Reporting and Evaluation Guidelines Results of a National Institutes of Health Working Group. JAMA DERMATOLOGY, 153(6), 587-592. DOI: 10.1001/jamadermatol.2017.0160

Stroke pharmacogenetics

(Chapter)

Walker, L. E., Stewart, A., & Pirmohamed, S. M. (2017). Stroke pharmacogenetics. In Stroke Genetics: Second Edition (pp. 327-410). DOI: 10.1007/978-3-319-56210-0_17

Systematic review: Baclofen dosing protocols for alcohol use disorders used in observational studies

(Journal article)

Thompson, A., Owens, L., Richardson, P., & Pirmohamed, M. (2017). Systematic review: Baclofen dosing protocols for alcohol use disorders used in observational studies. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 27(11), 1077-1089. DOI: 10.1016/j.euroneuro.2017.08.434

Temozolomide-induced drug rash with eosinophilia and systemic symptoms with positive lymphocyte transformation test

(Conference Paper)

Poyner, E., Naisbitt, D. J., Farrell, J., Nagarajan, S., Ellis, R., & Fatah, S. (2017). Temozolomide-induced drug rash with eosinophilia and systemic symptoms with positive lymphocyte transformation test. In BRITISH JOURNAL OF DERMATOLOGY Vol. 177 (pp. 27).

The Protekt study - a phase IIa, randomised, controlled, open-label trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis

(Conference Paper)

McWilliam, S. J., Antoine, D. J., Rosala-Hallas, A., Jones, A., MacLean, C., Prayle, A., . . . Pirmohamed, M. (2017). THE PROTEKT STUDY - A PHASE IIA, RANDOMISED, CONTROLLED, OPEN-LABEL TRIAL OF ROSUVASTATIN FOR THE PREVENTION OF AMINOGLYCOSIDE-INDUCED KIDNEY TOXICITY IN CHILDREN WITH CYSTIC FIBROSIS. In PEDIATRIC PULMONOLOGY Vol. 52 (pp. S353).

TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity

(Journal article)

Thiesen, S., Yin, P., Jorgensen, A. L., Zhang, J. E., Manzo, V., McEvoy, L., . . . Pirmohamed, M. (2017). TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity. PHARMACOGENETICS AND GENOMICS, 27(6), 213-222. DOI: 10.1097/FPC.0000000000000281

The HLA-A31:01* allele: influence on carbamazepine treatment

(Journal article)

Yip, V. L. M., & Pirmohamed, M. (2017). The HLA-A*31:01 allele: influence on carbamazepine treatment.. Pharmacogenomics and personalized medicine, 10, 29-38. DOI: 10.2147/PGPM.S108598

The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors

(Journal article)

Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2017). The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors. JOURNAL OF IMMUNOLOGY, 199(4), 1223-1237. DOI: 10.4049/jimmunol.1602029

The molecular genetics of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis

(Journal article)

Cliff, J., Jorgensen, A. L., Lord, R., Azam, F., Cossar, L., Carr, D. F., & Pirmohamed, M. (2017). The molecular genetics of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 120, 127-140. DOI: 10.1016/j.critrevonc.2017.09.009

Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury

(Journal article)

Carr, D. F., Ayehunie, S., Davies, A., Duckworth, C. A., French, S., Hall, N., . . . Pirmohamed, M. (2017). Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury. PHARMACOLOGY & THERAPEUTICS, 172, 181-194. DOI: 10.1016/j.pharmthera.2017.01.002

Trimethoprim-induced aseptic meningism

(Journal article)

Lochlainn, M. N., Gooi, H. C., Ogese, M. O., Naisbitt, D. J., & Jafar-Mohammadi, B. (2017). Trimethoprim-induced aseptic meningism. BRITISH JOURNAL OF HOSPITAL MEDICINE, 78(2), 108-109.

Whole exome sequencing in individuals with statin-induced myopathy

(Conference Paper)

Bloch, K. M., Carr, D., Pirmohamed, M., Morris, A., Maroteau, C., Eriksson, N., . . . Alfirevic, A. (2017). Whole exome sequencing in individuals with statin-induced myopathy. In DRUG SAFETY Vol. 40 (pp. 1026).

Zoonotic Transfer of Clostridium difficile Harboring Antimicrobial Resistance between Farm Animals and Humans

(Journal article)

Knetsch, C. W., Kumar, N., Forster, S. C., Connor, T. R., Browne, H. P., Harmanus, C., . . . Lawley, T. D. (2018). Zoonotic Transfer of Clostridium difficile Harboring Antimicrobial Resistance between Farm Animals and Humans. JOURNAL OF CLINICAL MICROBIOLOGY, 56(3). DOI: 10.1128/JCM.01384-17