We have one of the largest international bioresources of samples, including DNA, biofluids, and tissue biopsies, from 18,933 ADR patients. The rare nature of many of the ADRs that we study means that we must recruit patients regionally and nationally. We have therefore opened a total of 451 study-specific sites across the UK under CDSS ethics. 

Study Description

Sites (n)

Patients (n)

Bioresource

Antipsychotic-induced cardiometabolic toxicity

3

50

DNA; plasma/serum; urine

ABC transporters in paediatric IBD

1

61

 

Biomarkers of Paracetamol hepatotoxicity

12

402

DNA; plasma/serum; urine

Clostridium Difficile predisposition Study

5

1208

DNA; plasma/serum; urine; PBMC; stool

Various international research and industrial collaborations on drug hypersensitivity.

2

200

DNA; plasma/serum; PBMCs; skin biopsy

Folic acid adjuvant to anti-depressant therapy.

3

576

DNA

Genotyped Healthy volunteers for phase I clinical studies

18

3047

DNA; plasma

HLA-typed healthy volunteers

1

1218

DNA; PBMCs

Drug Hypersensitivity study (HYST)

9

159

DNA; plasma/serum; urine; PBMC; stool; various tissue biopsies

IFN-β Hypersensitivity in multiple sclerosis

2

30

DNA

Molecular genetics of ADRs in children

11

564

DNA

Methadone PgX of dose and ADRs

3

250

DNA; saliva

Molecular Genetics of ADRs (including Drug Hypersensitivity study, HYST)

183

2429

DNA; plasma/serum; urine; PBMC; stool; various tissue biopsies

NSAID-induced gastric ulceration

15

1469

DNA; plasma/serum; urine; antrum and ulcer biopsy

PGx of Adrenal Suppression with Inhaled steroids in COPD

16

291

DNA; plasma/serum

PGx of Adrenal Suppression with Inhaled steroids in asthma

3

600

DNA; plasma/serum; saliva

Role of Porphyrins in Anti-Tuberculous Drug-Induced Liver Injury

4

35

DNA; plasma/serum; urine

Dosing algorithms in warfarin extreme responder phenotypes

9

349

DNA

Pharmacology Biobank

1

368

DNA; PBMC; plasma/serum

Pharmacogenomics of Acute Coronary Syndrome

18

1561

DNA; plasma/serum

Clinical Implementation of pre-emptive PGx testing

2

621

DNA; saliva

Statin-induced myopathy from CPRD

141

975

DNA; plasma/serum; urine; saliva

PGx of tamoxifen response in breast cancer

2

89

DNA

NHS Chair Warfarin PGx study and PGX approach to coumarin anticoagulant therapy

12

2006

DNA; plasma/serum

Warfarin anticoagulation in patients in Sub-Saharan Africa

2

274

DNA

Warfarin dosing and PGx in paediatrics

2

101

DNA

For more information on any of these resources please contact us at cdss@liverpool.ac.uk