Drug-induced gastrointestinal toxicity

Focusing on both upper and lower gastrointestinal (GI) toxicity, our research in this programme assesses the ways in which drugs are toxic to the GI tract.

The upper GI studies focus on non-steroidal anti-inflammatory drugs (NSAID) induced ulceration (a multi-factorial disease) where we have identified a novel mechanistic pathway that perturbs cell survival. For lower GI toxicity, our focus is on anti-cancer medicines, including conventional chemotherapeutics, kinase inhibitors, and immune checkpoint inhibitors - all of which are associated with significant incidences of diarrhoea and colitis.

This research theme utilises cellular (including gastroids and enteroids), endoscopic, imaging and patient studies, along with the use of UK biobank (where appropriate) to understand the fundamental mechanisms of the adverse drug reactions (ADRs).

We have built a valuable resource through recruitment of deeply phenotyped patients and we will expand this resource (particularly in the lower GI area) through collaboration with cancer centres.

CDSS investigators

Back to: Centre for Drug Safety Science

Mark Pritchard

Professor Mark Pritchard

Theme lead

Professor of Gastroenterology


Dan Carr

Dr Dan Carr

Lecturer in Pharmacology


Headshot silhouette

Professor Gerry Cohen

Professor of Cancer Pharmacology


Carrie Duckworth

Dr Carrie Duckworth

Lecturer in Gastroenterology


Professor Sir Munir Pirmohamed

Professor Sir Munir Pirmohamed

Professor of Molecular and Clinical Pharmacology


Dr Shankar Varadarajan

Dr Shankar Varadarajan

Lecturer in Molecular and Clinical Cancer Medicine