2020
Tailor, A., Meng, X., Adair, K., Farrell, J., Waddington, J. C., Daly, A., . . . Naisbitt, D. J. (2020). HLA DaB1*15:01-DQB1*06:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts. TOXICOLOGICAL SCIENCES, 178(1), 115-126. doi:10.1093/toxsci/kfaa128DOI: 10.1093/toxsci/kfaa128
Waddington, J. C., Meng, X., Illing, P. T., Tailor, A., Adair, K., Whitaker, P., . . . Park, B. K. (2020). Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation. TOXICOLOGICAL SCIENCES, 177(2), 454-465. doi:10.1093/toxsci/kfaa124DOI: 10.1093/toxsci/kfaa124
Thomson, P. J., Illing, P. T., Farrell, J., Alhaidari, M., Bell, C. C., Berry, N., . . . Naisbitt, D. J. (2020). Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation. ALLERGY, 75(3), 636-647. doi:10.1111/all.14057DOI: 10.1111/all.14057
2019
Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo (Journal article)
Tailor, A., Waddington, J. C., Hamlett, J., Maggs, J., Kafu, L., Farrell, J., . . . Meng, X. (2019). Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo. CHEMICAL RESEARCH IN TOXICOLOGY, 32(10), 2095-2106. doi:10.1021/acs.chemrestox.9b00282DOI: 10.1021/acs.chemrestox.9b00282
2018
HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors (Journal article)
Usui, T., Tailor, A., Faulkner, L., Meng, X., Farrell, J., Daly, A. K., . . . Naisbitt, D. J. (2018). HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 31(10), 1022-1024. doi:10.1021/acs.chemrestox.8b00163DOI: 10.1021/acs.chemrestox.8b00163
Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity (Journal article)
Usui, T., Faulkner, L., Farrell, J., French, N. S., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2018). Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity. CHEMICAL RESEARCH IN TOXICOLOGY, 31(3), 165-167. doi:10.1021/acs.chemrestox.8b00030DOI: 10.1021/acs.chemrestox.8b00030
sullivan, A., Wang, E., Farrell, J., Whitaker, P., Faulkner, L., Peckham, D., . . . Naisbitt, D. (2018). β-lactam hypersensitivity involves expansion of circulating and skin-resident Th22 cells. Journal of Allergy and Clinical Immunology, 141(01), 235-249.E8. doi:10.1016/j.jaci.2017.01.020DOI: 10.1016/j.jaci.2017.01.020
2017
Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors (Journal article)
Alzahrani, A., Ogese, M., Meng, X., Waddington, J. C., Tailor, A., Farrell, J., . . . Naisbitt, D. (2017). Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2174-2186. doi:10.1021/acs.chemrestox.7b00263DOI: 10.1021/acs.chemrestox.7b00263
Amali, M. O., Sullivan, A., Jenkins, R. E., Farrell, J., Meng, X., Faulkner, L., . . . Naisbitt, D. J. (2017). Detection of drug-responsive B lymphocytes and antidrug IgG in patients with β-lactam hypersensitivity. ALLERGY, 72(6), 896-907. doi:10.1111/all.13087DOI: 10.1111/all.13087
Usui, T., Meng, X., Saide, K., Farrell, J., Thomson, P., Whitaker, P., . . . Naisbitt, D. J. (2017). Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury. TOXICOLOGICAL SCIENCES, 155(2), 420-431. doi:10.1093/toxsci/kfw218DOI: 10.1093/toxsci/kfw218
Temozolomide-induced drug rash with eosinophilia and systemic symptoms with positive lymphocyte transformation test (Conference Paper)
Poyner, E., Naisbitt, D. J., Farrell, J., Nagarajan, S., Ellis, R., & Fatah, S. (2017). Temozolomide-induced drug rash with eosinophilia and systemic symptoms with positive lymphocyte transformation test. In BRITISH JOURNAL OF DERMATOLOGY Vol. 177 (pp. 27). Retrieved from https://www.webofscience.com/
2016
7th drug hypersensitivity meeting: part one (Journal article)
Carr, D. F., Chung, W. -H., Jenkiins, R. E., Chaponda, M., Nwikue, G., Cornejo Castro, E. M., . . . Ruano, F. J. (2016). 7th drug hypersensitivity meeting: part one. Clinical and Translational Allergy, 6(S3). doi:10.1186/s13601-016-0121-zDOI: 10.1186/s13601-016-0121-z
2015
Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation (Journal article)
Naisbitt, D., Yang, E. L., Alhaidari, M., Berry, N., Lawrenson, A. S., Farrell, J., . . . Park, B. (2015). Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation. AIDS, 29(18), 2385-2395. doi:10.1097/QAD.0000000000000867DOI: 10.1097/QAD.0000000000000867
Cutaneous immunopathology of long-standing complex regional pain syndrome (Journal article)
Osborne, S., Farrell, J., Dearman, R. J., MacIver, K., Naisbitt, D., Moots, R., . . . Goebel, A. (2015). Cutaneous immunopathology of long-standing complex regional pain syndrome. European Journal of Pain, 19(10), 1516-1526. doi:10.1002/ejp.685DOI: 10.1002/ejp.685
Kim, S. -H., Saide, K., Farrell, J., Faulkner, L., Tailor, A., Ogese, M., . . . Naisbitt, D. J. (2015). Characterization of amoxicillin‐ and clavulanic acid‐specific T cells in patients with amoxicillin‐clavulanate–induced liver injury. Hepatology, 62(3), 887-899. doi:10.1002/hep.27912DOI: 10.1002/hep.27912
CD4+and CD8+T-cells isolated from blood and skin of patients with β-lactam hypersensitivity secrete Interleukin-22, but not Interleukin-17 (Conference Paper)
Sullivan, A., Faulkner, L., Farrell, J., Whitaker, P., Peckham, D., Park, B. K., & Naisbitt, D. (2015). CD4+and CD8+T-cells isolated from blood and skin of patients with β-lactam hypersensitivity secrete Interleukin-22, but not Interleukin-17. In ALLERGY Vol. 70 (pp. 25-26). Retrieved from https://www.webofscience.com/
2014
Partial mitigation of gold nanoparticle-interactions with human lymphocytes by surface functionalization with a 'mixed-matrix' (Journal article)
Liptrott, N. J., Kendall, E., Nieves, D. J., Farrell, J., Rannard, S., Fernig, D. G., & Owen, A. (2014). Partial mitigation of gold nanoparticle-interactions with human lymphocytes by surface functionalization with a 'mixed-matrix'. Nanomedicine, 9(16), 2467-2479. doi:10.2217/nnm.14.38DOI: 10.2217/nnm.14.38
Abs No: HLA-A*31:01 positive hypersensitive patient (Journal article)
Lichtenfels, M., Farrell, J., Ogese, M., Bell, C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). Abs No: HLA-A*31:01 positive hypersensitive patient. Clinical and translational allergy, 4(Suppl 3), P117. doi:10.1186/2045-7022-4-s3-p117DOI: 10.1186/2045-7022-4-s3-p117
Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis (Journal article)
Amali, M., Sullivan, A., Farrell, J., Meng, X., Jenkins, R., Whitaker, P., . . . Naisbitt, D. J. (2014). Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis. Clinical and translational allergy, 4(Suppl 3), P113. doi:10.1186/2045-7022-4-s3-p113DOI: 10.1186/2045-7022-4-s3-p113
Characterization of the TCR V repertoire of piperacillin-specific T-cells (Journal article)
Al-Attar, Z., Faulkner, L., Farrell, J., Whitaker, P., Peckham, D., Park, K., & Naisbitt, D. (2014). Characterization of the TCR V repertoire of piperacillin-specific T-cells. Clinical and translational allergy, 4(Suppl 3), P39. doi:10.1186/2045-7022-4-s3-p39DOI: 10.1186/2045-7022-4-s3-p39
Detection of interleukin-22 secreting T-cells in piperacillin hypersensitive patients with cystic fibrosis (Journal article)
Sullivan, A., Wang, E., Farrell, J., Whitaker, P., Peckham, D., Park, B. K., & Naisbitt, D. (2014). Detection of interleukin-22 secreting T-cells in piperacillin hypersensitive patients with cystic fibrosis. Clinical and translational allergy, 4(Suppl 3), P108. doi:10.1186/2045-7022-4-s3-p108DOI: 10.1186/2045-7022-4-s3-p108
HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient (Journal article)
Lichtenfels, M., Farrell, J., Ogese, M. O., Bell, C. C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient. Chemical Research in Toxicology, 27(02), 175-177. doi:10.1021/tx400460wDOI: 10.1021/tx400460w
Partial mitigation of gold nanoparticle interactions with human lymphocytes by surface functionalization with a 'mixed matrix' (Journal article)
Liptrott, N. J., Kendall, E., Nieves, D. J., Farrell, J., Rannard, S., Fernig, D. G., & Owen, A. (2014). Partial mitigation of gold nanoparticle interactions with human lymphocytes by surface functionalization with a 'mixed matrix'. Nanomedicine (London).
2013
The Generation, Detection, and Effects of Reactive Drug Metabolites (Journal article)
Stachulski, A. V., Baillie, T. A., Park, B. K., Obach, R. S., Dalvie, D. K., Williams, D. P., . . . Lennard, M. S. (2013). The Generation, Detection, and Effects of Reactive Drug Metabolites. MEDICINAL RESEARCH REVIEWS, 33(5), 985-1080. doi:10.1002/med.21273DOI: 10.1002/med.21273
β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis (Journal article)
Jenkins, R. E., Yaseen, F. S., Monshi, M. M., Whitaker, P., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2013). β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 26(6), 963-975. doi:10.1021/tx400124mDOI: 10.1021/tx400124m
T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms (Journal article)
Bell, C. C., Faulkner, L., Martinsson, K., Farrell, J., Alfirevic, A., Tugwood, J., . . . Park, B. K. (2013). T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms. CHEMICAL RESEARCH IN TOXICOLOGY, 26(5), 759-766. doi:10.1021/tx400060pDOI: 10.1021/tx400060p
Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury (Journal article)
Monshi, M. M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2013). Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 57(2), 727-739. doi:10.1002/hep.26077DOI: 10.1002/hep.26077
Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives (Journal article)
Farrell, J., Lichtenfels, M., Sullivan, A., Elliott, E. C., Alfirevic, A., Stachulski, A. V., . . . Park, B. K. (2013). Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(2), 493-495. doi:10.1016/j.jaci.2013.02.045DOI: 10.1016/j.jaci.2013.02.045
Characterization of the B cell response in piperacillin hypersensitive patients with cystic fibrosis (Conference Paper)
Amali, M., Sullivan, A., Yaseen, F. S., Farrell, J., Faulkner, L., Whitaker, P., . . . Naisbitt, D. J. (2013). Characterization of the B cell response in piperacillin hypersensitive patients with cystic fibrosis. In IMMUNOLOGY Vol. 140 (pp. 192). Retrieved from https://www.webofscience.com/
2012
IL-8 Release from Human Neutrophils Cultured with Pro-Haptenic Chemical Sensitizers (Journal article)
Kiorpelidou, E., Foster, B., Farrell, J., Ogese, M. O., Faulkner, L., Goldring, C. E., . . . Naisbitt, D. J. (2012). IL-8 Release from Human Neutrophils Cultured with Pro-Haptenic Chemical Sensitizers. CHEMICAL RESEARCH IN TOXICOLOGY, 25(10), 2054-2056. doi:10.1021/tx300350sDOI: 10.1021/tx300350s
Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis (Journal article)
El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900DOI: 10.1124/jpet.111.190900
HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury (Journal article)
Monshi, M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2012). HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology.
2011
Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients (Journal article)
Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871DOI: 10.1124/jpet.111.183871
Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients (Journal article)
Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 338(3), 841-849. doi:10.1124/jpet.111.183871DOI: 10.1124/jpet.111.183871
Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways (Journal article)
El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. -K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways. CHEMICAL RESEARCH IN TOXICOLOGY, 24(6), 791-793. doi:10.1021/tx2001256DOI: 10.1021/tx2001256
Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury (Journal article)
El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. -K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 128(3), 680-U368. doi:10.1016/j.jaci.2011.04.031DOI: 10.1016/j.jaci.2011.04.031
Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis (Journal article)
Elsheikh, A., Castrejon, L., Lavergne, S. N., Whitaker, P., Monshi, M., Callan, H., . . . Naisbitt, D. J. (2011). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(6), 1543-U348. doi:10.1016/j.jaci.2010.12.1119DOI: 10.1016/j.jaci.2010.12.1119
Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis. (Journal article)
Elsheikh, A., Castrejon, L., Lavergne, S. N., Whitaker, P., Monshi, M., Callan, H., . . . Naisbitt, D. J. (2011). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis.. The Journal of allergy and clinical immunology, 127(6), 1543-51.e3. doi:10.1016/j.jaci.2010.12.1119DOI: 10.1016/j.jaci.2010.12.1119
2010
Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism (Journal article)
Elsheikh, A., Lavergne, S. N., Castrejon, J. L., Farrell, J., Wang, H., Sathish, J., . . . Naisbitt, D. J. (2010). Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism. JOURNAL OF IMMUNOLOGY, 185(11), 6448-6460. doi:10.4049/jimmunol.1000889DOI: 10.4049/jimmunol.1000889
Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives (Journal article)
Castrejon, J. L., Lavergne, S. N., El-Sheikh, A., Farrell, J., Maggs, J. L., Sabbani, S., . . . Naisbitt, D. J. (2010). Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives. CHEMICAL RESEARCH IN TOXICOLOGY, 23(1), 184-192. doi:10.1021/tx900329bDOI: 10.1021/tx900329b
Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in <i>p</i>-Phenylenediamine Allergic Patients and Tolerant Individuals (Journal article)
Coulter, E. M., Jenkinson, C., Farrell, J., Lavergne, S. N., Pease, C., White, A., . . . Naisbitt, D. J. (2010). Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in <i>p</i>-Phenylenediamine Allergic Patients and Tolerant Individuals. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(1), 161-174. doi:10.1038/jid.2009.187DOI: 10.1038/jid.2009.187
2009
Investigation of the immunogenicity of <i>p</i>-phenylenediamine and Bandrowski's base in the mouse (Journal article)
Farrell, J., Jenkinson, C., Lavergne, S. N., Maggs, J. L., Park, B. K., & Naisbitt, D. J. (2009). Investigation of the immunogenicity of <i>p</i>-phenylenediamine and Bandrowski's base in the mouse. TOXICOLOGY LETTERS, 185(3), 153-159. doi:10.1016/j.toxlet.2008.12.008DOI: 10.1016/j.toxlet.2008.12.008
2008
Activation of T-Cells from allergic patients and volunteers by <i>p</i>-phenylenediamine and Bandrowski's base (Journal article)
Coulter, E. M., Jenkinson, C., Wu, Y., Farrell, J., Foster, B., Smith, A., . . . Naisbitt, D. J. (2008). Activation of T-Cells from allergic patients and volunteers by <i>p</i>-phenylenediamine and Bandrowski's base. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128(4), 897-905. doi:10.1038/sj.jid.5701071DOI: 10.1038/sj.jid.5701071
2007
Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling (Journal article)
Sanderson, J. P., Naisbitt, D. J., Farrell, J., Ashby, C. A., Tucker, M. J., Rieder, M. J., . . . Park, B. K. (2007). Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. JOURNAL OF IMMUNOLOGY, 178(9), 5533-5542. doi:10.4049/jimmunol.178.9.5533DOI: 10.4049/jimmunol.178.9.5533
Generation and characterization of antigen-specific CD4<SUP>+</SUP>, CD8<SUP>+</SUP>, and CD4<SUP>+</SUP>CD8<SUP>+</SUP> T-cell clones from patients with carbamazopine hypersensitivity (Journal article)
Wu, Y., Farrell, J., Pirmohmed, M., Park, B. K., & Naisbitt, D. J. (2007). Generation and characterization of antigen-specific CD4<SUP>+</SUP>, CD8<SUP>+</SUP>, and CD4<SUP>+</SUP>CD8<SUP>+</SUP> T-cell clones from patients with carbamazopine hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 119(4), 973-981. doi:10.1016/j.jaci.2006.12.617DOI: 10.1016/j.jaci.2006.12.617
Activation of human dendritic cells by <i>p</i>-phenylenediamine (Journal article)
Coulter, E. M., Farrell, J., Mathews, K. L., Maggs, J. L., Pease, C. K., Lockley, D. J., . . . Naisbitt, D. J. (2007). Activation of human dendritic cells by <i>p</i>-phenylenediamine. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 320(2), 885-892. doi:10.1124/jpet.106.113803DOI: 10.1124/jpet.106.113803
2006
Systemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartan (Journal article)
Constable, S., Farrell, J., Naisbitt, D., King, C., Leonard, N., & Pirmohamed, M. (2006). Systemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartan. BRITISH JOURNAL OF DERMATOLOGY, 155(2), 491-493. doi:10.1111/j.1365-2133.2006.07338.xDOI: 10.1111/j.1365-2133.2006.07338.x
Activation of T cells by carbamazepine and carbamazepine metabolites (Journal article)
Wu, Y., Sanderson, J. P., Farrell, J., Drummond, N. S., Hanson, A., Bowkett, E., . . . Naisbitt, D. J. (2006). Activation of T cells by carbamazepine and carbamazepine metabolites. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 118(1), 233-241. doi:10.1016/j.jaci.2006.03.005DOI: 10.1016/j.jaci.2006.03.005
2005
Characterization of the T-cell response in a patient with phenindione hypersensitivity (Journal article)
Naisbitt, D. J., Farrell, J., Chamberlain, P. J., Hopkins, J. E., Berry, N. G., Pirmohamed, M., & Park, B. K. (2005). Characterization of the T-cell response in a patient with phenindione hypersensitivity. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 313(3), 1058-1065. doi:10.1124/jpet.105.083758DOI: 10.1124/jpet.105.083758
2003
Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-Cell responses in animals and humans (Journal article)
Farrell, J., Naisbitt, D. J., Drummond, N. S., Depta, J. P. H., Vilar, F. J., Pirmohamed, M., & Park, B. K. (2003). Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-Cell responses in animals and humans. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 306(1), 229-237. doi:10.1124/jpet.103.050112DOI: 10.1124/jpet.103.050112
Characterization of drug-specific T cells in lamotrigine hypersensitivity (Journal article)
Naisbitt, D. J., Farrell, J., Wong, G., Depta, J. P. H., Dodd, C. C., Hopkins, J. E., . . . Park, B. K. (2003). Characterization of drug-specific T cells in lamotrigine hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 111(6), 1393-1403. doi:10.1067/mai.2003.1507DOI: 10.1067/mai.2003.1507
Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones (Journal article)
Naisbitt, D. J., Britschgi, M., Wong, G., Farrell, J., Depta, J. P. H., Chadwick, D. W., . . . Park, B. K. (2003). Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones. MOLECULAR PHARMACOLOGY, 63(3), 732-741. doi:10.1124/mol.63.3.732DOI: 10.1124/mol.63.3.732
2002
Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation (Journal article)
Naisbitt, D. J., Farrell, J., Gordon, S. F., Maggs, J. L., Burkhart, C., Pichler, W. J., . . . Park, B. K. (2002). Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation. MOLECULAR PHARMACOLOGY, 62(3), 628-637. doi:10.1124/mol.62.3.628DOI: 10.1124/mol.62.3.628
