2024
Correction to: A<sub>1</sub>R-A<sub>2A</sub>R heteromers coupled to G<sub>s</sub> and G<sub>i/0</sub> proteins modulate GABA transport into astrocytes. (Journal article)
Cristóvão-Ferreira, S., Navarro, G., Brugarolas, M., Pérez-Capote, K., Vaz, S. H., Fattorini, G., . . . Sebastião, A. M. (2024). Correction to: A<sub>1</sub>R-A<sub>2A</sub>R heteromers coupled to G<sub>s</sub> and G<sub>i/0</sub> proteins modulate GABA transport into astrocytes.. Purinergic signalling. doi:10.1007/s11302-024-10012-3DOI: 10.1007/s11302-024-10012-3
A potent neutralizing nanobody targeting a unique epitope on the receptor-binding domain of SARS-CoV-2 spike protein. (Journal article)
Zhang, Y., Wang, D., Xiang, Q., Hu, X., Zhang, Y., Wu, L., . . . Li, J. (2024). A potent neutralizing nanobody targeting a unique epitope on the receptor-binding domain of SARS-CoV-2 spike protein.. Virology, 589, 109925. doi:10.1016/j.virol.2023.109925DOI: 10.1016/j.virol.2023.109925
2023
Gain-of-function mutation F278C in MC2R results in reduced beta-1-arrestin recruitment and increased cAMP implicating impairment of S280 phosphorylation (Journal article)
Popat, D., Xu, R., McCormick, P., & Chan, L. (n.d.). Gain-of-function mutation F278C in MC2R results in reduced beta-1-arrestin recruitment and increased cAMP implicating impairment of S280 phosphorylation. Endocrine Abstracts. doi:10.1530/endoabs.94.oc5.2DOI: 10.1530/endoabs.94.oc5.2
Development of Melanocortin 4 Receptor Agonists by Exploiting Animal-Derived Macrocyclic, Disulfide-Rich Peptide Scaffolds. (Journal article)
Muratspahić, E., Aslanoglou, D., White, A. M., Draxler, C., Kozisek, X., Farooq, Z., . . . Gruber, C. W. (2023). Development of Melanocortin 4 Receptor Agonists by Exploiting Animal-Derived Macrocyclic, Disulfide-Rich Peptide Scaffolds.. ACS pharmacology & translational science, 6(10), 1373-1381. doi:10.1021/acsptsci.3c00090DOI: 10.1021/acsptsci.3c00090
Relton, E. L., Roth, N. J., Yasa, S., Kaleem, A., Hermey, G., Minnis, C. J., . . . Locker, N. (2023). The Batten disease protein CLN3 is important for stress granules dynamics and translational activity.. The Journal of biological chemistry, 299(5), 104649. doi:10.1016/j.jbc.2023.104649DOI: 10.1016/j.jbc.2023.104649
Characterization of dominant-negative growth hormone receptor variants reveals a potential therapeutic target for short stature. (Journal article)
Andrews, A., Cottrell, E., Maharaj, A., Ladha, T., Williams, J., Schilbach, K., . . . Storr, H. L. (2023). Characterization of dominant-negative growth hormone receptor variants reveals a potential therapeutic target for short stature.. European journal of endocrinology, 188(4), 353-365. doi:10.1093/ejendo/lvad039DOI: 10.1093/ejendo/lvad039
Wnt signalling in the articular cartilage: A matter of balance (Journal article)
Gill, A. K., McCormick, P. J., Sochart, D., & Nalesso, G. (2023). Wnt signalling in the articular cartilage: A matter of balance. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 104(2), 56-63. doi:10.1111/iep.12472DOI: 10.1111/iep.12472
Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion (Journal article)
Tomas Bort, E., Joseph, M. D., Wang, Q., Carter, E. P., Roth, N. J., Gibson, J., . . . Grose, R. P. (2023). Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion. ELIFE, 12. doi:10.7554/eLife.86971DOI: 10.7554/eLife.86971
Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists (Journal article)
Kosar, M., Sarott, R. C., Sykes, D. A., Viray, A. E. G., Vitale, R. M., Tomašević, N., . . . Carreira, E. M. (n.d.). Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists. ACS Central Science. doi:10.1021/acscentsci.3c01461DOI: 10.1021/acscentsci.3c01461
2022
Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor (Journal article)
Hu, X., Lin, C., Xu, Q., Zhou, X., Zeng, P., McCormick, P. J., . . . Zhang, J. (2022). Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor. VIRUSES-BASEL, 14(9). doi:10.3390/v14092075DOI: 10.3390/v14092075
Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814 (Journal article)
Li, J., Lin, C., Zhou, X., Zhong, F., Zeng, P., McCormick, P. J., . . . Zhang, J. (2022). Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814. JOURNAL OF MOLECULAR BIOLOGY, 434(16). doi:10.1016/j.jmb.2022.167706DOI: 10.1016/j.jmb.2022.167706
Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine (Journal article)
Aslanoglou, D., Bertera, S., Friggeri, L., Sanchez-Soto, M., Lee, J., Xue, X., . . . Freyberg, Z. (2022). Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine. ISCIENCE, 25(8). doi:10.1016/j.isci.2022.104771DOI: 10.1016/j.isci.2022.104771
Probing GPCR Dimerization Using Peptides (Journal article)
Farooq, Z., Howell, L. A., & McCormick, P. J. (2022). Probing GPCR Dimerization Using Peptides. FRONTIERS IN ENDOCRINOLOGY, 13. doi:10.3389/fendo.2022.843770DOI: 10.3389/fendo.2022.843770
Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe (Journal article)
Gazzi, T., Brennecke, B., Atz, K., Korn, C., Sykes, D., Forn-Cuni, G., . . . Nazare, M. (2022). Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe. CHEMICAL SCIENCE, 13(19), 5539-5545. doi:10.1039/d1sc06659eDOI: 10.1039/d1sc06659e
Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332 (Journal article)
Li, J., Lin, C., Zhou, X., Zhong, F., Zeng, P., Yang, Y., . . . Zhang, J. (2022). Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332. JOURNAL OF VIROLOGY, 96(8). doi:10.1128/jvi.02013-21DOI: 10.1128/jvi.02013-21
Cryo-EM structure of mouse TRPML2 in lipid nanodiscs (Journal article)
Song, X., Li, J., Tian, M., Zhu, H., Hu, X., Zhang, Y., . . . Zhang, J. (2022). Cryo-EM structure of mouse TRPML2 in lipid nanodiscs. JOURNAL OF BIOLOGICAL CHEMISTRY, 298(2). doi:10.1016/j.jbc.2021.101487DOI: 10.1016/j.jbc.2021.101487
Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus (Journal article)
Zhang, Y., Gao, H., Hu, X., Wang, Q., Zhong, F., Zhou, X., . . . Li, J. (2022). Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus. JOURNAL OF VIROLOGY, 96(1). Retrieved from https://www.webofscience.com/
Palmitoylation and G-protein coupled receptors (Chapter)
Chalhoub, G., & McCormick, P. J. (2022). Palmitoylation and G-protein coupled receptors. In G PROTEIN-COUPLED RECEPTORS, PT A (Vol. 193, pp. 195-211). doi:10.1016/bs.pmbts.2022.09.002DOI: 10.1016/bs.pmbts.2022.09.002
2021
Probe Confined Dynamic Mapping for G Protein-Coupled Receptor Allosteric Site Prediction (Journal article)
Ciancetta, A., Gill, A. K., Ding, T., Karlov, D. S., Chalhoub, G., McCormick, P. J., & Tikhonova, I. G. (2021). Probe Confined Dynamic Mapping for G Protein-Coupled Receptor Allosteric Site Prediction. ACS CENTRAL SCIENCE, 7(11), 1847-1862. doi:10.1021/acscentsci.1c00802DOI: 10.1021/acscentsci.1c00802
Quantitative Super-Resolution Imaging for the Analysis of GPCR Oligomerization (Journal article)
Joseph, M. D., Bort, E. T., Grose, R. P., McCormick, P. J., & Simoncelli, S. (2021). Quantitative Super-Resolution Imaging for the Analysis of GPCR Oligomerization. BIOMOLECULES, 11(10). doi:10.3390/biom11101503DOI: 10.3390/biom11101503
Identification of BiP as a CB<sub>1</sub> Receptor-Interacting Protein That Fine-Tunes Cannabinoid Signaling in the Mouse Brain (Journal article)
Costas-Insua, C., Moreno, E., Maroto, I. B., Ruiz-Calvo, A., Bajo-Graneras, R., Martin-Gutierrez, D., . . . Guzman, M. (2021). Identification of BiP as a CB<sub>1</sub> Receptor-Interacting Protein That Fine-Tunes Cannabinoid Signaling in the Mouse Brain. JOURNAL OF NEUROSCIENCE, 41(38), 7924-7941. doi:10.1523/JNEUROSCI.0821-21.2021DOI: 10.1523/JNEUROSCI.0821-21.2021
Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signalling (Journal article)
H, I., O, D., F, F., V, C., AK, G., NJ, R., . . . M, S. -B. (n.d.). Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signalling. Yearbook of Paediatric Endocrinology. doi:10.1530/ey.18.11.2DOI: 10.1530/ey.18.11.2
To eat or not to eat: Cryo-EM structure of melanocortin receptor 4 reveals mechanism of a "hunger switch" initiating satiety signaling (Conference Paper)
Degtjarik, O., Israeli, H., Chan, L. F., Ben-Zvi, D., Niv, M. Y., McCormick, P. J., & Shalev-Benami, M. (2021). To eat or not to eat: Cryo-EM structure of melanocortin receptor 4 reveals mechanism of a "hunger switch" initiating satiety signaling. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 77 (pp. C480). Retrieved from https://www.webofscience.com/
Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling (Journal article)
Israeli, H., Degtjarik, O., Fierro, F., Chunilal, V., Gill, A. K., Roth, N. J., . . . Shalev-Benami, M. (2021). Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling. SCIENCE, 372(6544), 808-+. doi:10.1126/science.abf7958DOI: 10.1126/science.abf7958
Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode (Journal article)
Li, J., Zhou, X., Zhang, Y., Zhong, F., Lin, C., McCormick, P. J., . . . Zhang, J. (2021). Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode. SCIENCE BULLETIN, 66(7), 661-663. doi:10.1016/j.scib.2020.10.018DOI: 10.1016/j.scib.2020.10.018
Structure of SARS-CoV-2 main protease in the apo state (Journal article)
Zhou, X., Zhong, F., Lin, C., Hu, X., Zhang, Y., Xiong, B., . . . Zhang, J. (2021). Structure of SARS-CoV-2 main protease in the apo state. SCIENCE CHINA-LIFE SCIENCES, 64(4), 656-659. doi:10.1007/s11427-020-1791-3DOI: 10.1007/s11427-020-1791-3
Novel dominant negative GH receptor variants provide important insights into GH receptor physiology (Conference Paper)
Andrews, A., Cottrell, E., Maharaj, A., Ladha, T., Williams, J., Metherell, L. A., . . . Storr, H. L. (2021). Novel dominant negative GH receptor variants provide important insights into GH receptor physiology. In HORMONE RESEARCH IN PAEDIATRICS Vol. 94 (pp. 166). Retrieved from https://www.webofscience.com/
2020
Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells (Journal article)
Sarott, R. C., Westphal, M. V., Pfaff, P., Korn, C., Sykes, D. A., Gazzi, T., . . . Carreira, E. M. (2020). Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 142(40), 16953-16964. doi:10.1021/jacs.0c05587DOI: 10.1021/jacs.0c05587
Modulation of dopamine D<sub>1</sub> receptors via histamine H<sub>3</sub> receptors is a novel therapeutic target for Huntington's disease (Journal article)
Moreno-Delgado, D., Puigdellivol, M., Moreno, E., Rodriguez-Ruiz, M., Botta, J., Gasperini, P., . . . McCormick, P. J. (2020). Modulation of dopamine D<sub>1</sub> receptors via histamine H<sub>3</sub> receptors is a novel therapeutic target for Huntington's disease. ELIFE, 9. doi:10.7554/eLife.51093DOI: 10.7554/eLife.51093
Editorial: The Canonical and Non-Canonical Endocannabinoid System as a Target in Cancer and Acute and Chronic Pain (Journal article)
Contino, M., & McCormick, P. J. (2020). Editorial: The Canonical and Non-Canonical Endocannabinoid System as a Target in Cancer and Acute and Chronic Pain. FRONTIERS IN PHARMACOLOGY, 11. doi:10.3389/fphar.2020.00312DOI: 10.3389/fphar.2020.00312
Is the sigma-1 receptor a potential pharmacological target for cardiac pathologies? A systematic review (Journal article)
Lewis, R., Li, J., McCormick, P. J., Huang, C. L. -H., & Jeevaratnam, K. (2020). Is the sigma-1 receptor a potential pharmacological target for cardiac pathologies? A systematic review. IJC HEART & VASCULATURE, 26. doi:10.1016/j.ijcha.2019.100449DOI: 10.1016/j.ijcha.2019.100449
Continuing challenges in targeting oligomeric GPCR-based drugs (Chapter)
Botta, J., Appelhans, J., & McCormick, P. J. (2020). Continuing challenges in targeting oligomeric GPCR-based drugs. In OLIGOMERIZATION IN HEALTH AND DISEASE: FROM ENZYMES TO G PROTEIN-COUPLED RECEPTORS (Vol. 169, pp. 213-245). doi:10.1016/bs.pmbts.2019.11.009DOI: 10.1016/bs.pmbts.2019.11.009
2019
Site-Specific Encoding of Photoactivity in Antibodies Enables Light-Mediated Antibody-Antigen Binding on Live Cells (Journal article)
Bridge, T., Shaikh, S. A., Thomas, P., Botta, J., McCormick, P. J., & Sachdeva, A. (2019). Site-Specific Encoding of Photoactivity in Antibodies Enables Light-Mediated Antibody-Antigen Binding on Live Cells. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 58(50), 17986-17993. doi:10.1002/anie.201908655DOI: 10.1002/anie.201908655
Site‐Specific Encoding of Photoactivity in Antibodies Enables Light‐Mediated Antibody–Antigen Binding on Live Cells (Journal article)
Bridge, T., Shaikh, S. A., Thomas, P., Botta, J., McCormick, P. J., & Sachdeva, A. (2019). Site‐Specific Encoding of Photoactivity in Antibodies Enables Light‐Mediated Antibody–Antigen Binding on Live Cells. Angewandte Chemie, 131(50), 18154-18161. doi:10.1002/ange.201908655DOI: 10.1002/ange.201908655
Highly Specific, Fluorescent Cannabinoid Type 2 Receptor Probes Enable Applications in Microscopy, Flow Cytometry and FRET-based Binding Assays (Preprint)
DOI: 10.26434/chemrxiv.10288547.v1
Modulation of dopamine D<sub>1</sub> receptors via histamine H<sub>3</sub> receptors is a novel therapeutic target for Huntington’s disease (Preprint)
DOI: 10.1101/837658
Design and development of stapled transmembrane peptides that disrupt the activity of G-protein?coupled receptor oligomers (Journal article)
Botta, J., Bibic, L., Killoran, P., McCormick, P. J., & Howell, L. A. (2019). Design and development of stapled transmembrane peptides that disrupt the activity of G-protein?coupled receptor oligomers. JOURNAL OF BIOLOGICAL CHEMISTRY, 294(45), 16587-16603. doi:10.1074/jbc.RA119.009160DOI: 10.1074/jbc.RA119.009160
Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer (vol 116, pg 3863, 2019) (Journal article)
Blasco-Benito, S., Moreno, E., Seijo-Vila, M., Tundidor, I., Andradas, C., Caffarel, M. M., . . . Sanchez, C. (2019). Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer (vol 116, pg 3863, 2019). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(13), 6505. doi:10.1073/pnas.1903209116DOI: 10.1073/pnas.1903209116
Therapeutic targeting of HER2-CB<sub>2</sub>R heteromers in HER2-positive breast cancer (Journal article)
Blasco-Benito, S., Moreno, E., Seijo-Vila, M., Tundidor, I., Andradas, C., Caffarel, M. M., . . . Sanchez, C. (2019). Therapeutic targeting of HER2-CB<sub>2</sub>R heteromers in HER2-positive breast cancer. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(9), 3863-3872. doi:10.1073/pnas.1815034116DOI: 10.1073/pnas.1815034116
2018
Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences (Journal article)
Aringhieri, S., Carli, M., Kolachalam, S., Verdesca, V., Cini, E., Rossi, M., . . . Scarselli, M. (2018). Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences. PHARMACOLOGY & THERAPEUTICS, 192, 20-41. doi:10.1016/j.pharmthera.2018.06.012DOI: 10.1016/j.pharmthera.2018.06.012
Singular Location and Signaling Profile of Adenosine A<sub>2A</sub>-Cannabinoid CB<sub>1</sub> Receptor Heteromers in the Dorsal Striatum (Journal article)
Moreno, E., Chiarlone, A., Medrano, M., Puigdellivol, M., Bibic, L., Howell, L. A., . . . Guzman, M. (2018). Singular Location and Signaling Profile of Adenosine A<sub>2A</sub>-Cannabinoid CB<sub>1</sub> Receptor Heteromers in the Dorsal Striatum. NEUROPSYCHOPHARMACOLOGY, 43(5), 964-977. doi:10.1038/npp.2017.12DOI: 10.1038/npp.2017.12
Cross-communication between G<sub>i</sub> and G<sub>s</sub> in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain (Journal article)
Navarro, G., Cordomi, A., Brugarolas, M., Moreno, E., Aguinaga, D., Perez-Benito, L., . . . Franco, R. (2018). Cross-communication between G<sub>i</sub> and G<sub>s</sub> in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain. BMC BIOLOGY, 16. doi:10.1186/s12915-018-0491-xDOI: 10.1186/s12915-018-0491-x
2017
A Positive Allosteric Modulator of the Serotonin 5-HT<sub>2c</sub> Receptor for Obesity (Journal article)
Garcia-Carceles, J., Decara, J. M., Vazquez-Villa, H., Rodriguez, R., Codesido, E., Cruces, J., . . . Lopez-Rodriguez, M. L. (2017). A Positive Allosteric Modulator of the Serotonin 5-HT<sub>2c</sub> Receptor for Obesity. JOURNAL OF MEDICINAL CHEMISTRY, 60(23), 9575-9584. doi:10.1021/acs.jmedchem.7b00994DOI: 10.1021/acs.jmedchem.7b00994
Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor (Journal article)
Fahradpour, M., Keov, P., Tognola, C., Perez-Santamarina, E., McCormick, P. J., Ghassempour, A., & Gruber, C. W. (2017). Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor. FRONTIERS IN PHARMACOLOGY, 8. doi:10.3389/fphar.2017.00616DOI: 10.3389/fphar.2017.00616
<i>In vivo</i> monitoring of the recruitment and activation of AP-1 by Arf1 (Journal article)
Sauvageau, E., McCormick, P. J., & Lefrancois, S. (2017). <i>In vivo</i> monitoring of the recruitment and activation of AP-1 by Arf1. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-07493-1DOI: 10.1038/s41598-017-07493-1
Heteroreceptor Complexes Formed by Dopamine D<sub>1</sub>, Histamine H<sub>3</sub>, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer's Disease (Journal article)
Rodriguez-Ruiz, M., Moreno, E., Moreno-Delgado, D., Navarro, G., Mallol, J., Cortes, A., . . . Franco, R. (2017). Heteroreceptor Complexes Formed by Dopamine D<sub>1</sub>, Histamine H<sub>3</sub>, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer's Disease. MOLECULAR NEUROBIOLOGY, 54(6), 4537-4550. doi:10.1007/s12035-016-9995-yDOI: 10.1007/s12035-016-9995-y
A new serotonin 5-HT<sub>6</sub> receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding (Journal article)
Gonzalez-Vera, J. A., Medina, R. A., Martin-Fontecha, M., Gonzalez, A., de la Fuente, T., Vazquez-Villa, H., . . . Lopez-Rodriguez, M. L. (2017). A new serotonin 5-HT<sub>6</sub> receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding. SCIENTIFIC REPORTS, 7. doi:10.1038/srep41293DOI: 10.1038/srep41293
Heteromers Form Novel Signaling Complexes (Chapter)
McCormick, P. J., & Botta, J. (2017). Heteromers Form Novel Signaling Complexes. In G-PROTEIN-COUPLED RECEPTOR DIMERS (Vol. 33, pp. 467-475). doi:10.1007/978-3-319-60174-8_19DOI: 10.1007/978-3-319-60174-8_19
Long-Lasting Impairment of mGluR<sub>5</sub>-Activated Intracellular Pathways in the Striatum After Withdrawal of Cocaine Self-Administration (Journal article)
Hoffmann, H. M., Crouzin, N., Moreno, E., Raivio, N., Fuentes, S., McCormick, P. J., . . . Vignes, M. (2017). Long-Lasting Impairment of mGluR<sub>5</sub>-Activated Intracellular Pathways in the Striatum After Withdrawal of Cocaine Self-Administration. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 20(1). doi:10.1093/ijnp/pyw086DOI: 10.1093/ijnp/pyw086
Long-lasting impairment of mGluR<sub>5</sub>-activated intracellular pathways in the striatum after withdrawal of cocaine self-administration (vol 20, pg 72, 2017) (Journal article)
Hoffmann, H. M., Crouzin, N., Moreno, E., Raivio, N., Fuentes, S., McCormick, P. J., . . . Vignes, M. (2017). Long-lasting impairment of mGluR<sub>5</sub>-activated intracellular pathways in the striatum after withdrawal of cocaine self-administration (vol 20, pg 72, 2017). INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 20(1). doi:10.1093/ijnp/pyw104DOI: 10.1093/ijnp/pyw104
2016
The Insulin-Like Growth Factor I Receptor Regulates Glucose Transport by Astrocytes (Journal article)
Hernandez-Garzon, E., Fernandez, A. M., Perez-Alvarez, A., Genis, L., Bascunana, P., Fernandez de la Rosa, R., . . . Torres Aleman, I. (2016). The Insulin-Like Growth Factor I Receptor Regulates Glucose Transport by Astrocytes. GLIA, 64(11), 1962-1971. doi:10.1002/glia.23035DOI: 10.1002/glia.23035
Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure (Journal article)
Busnelli, M., Kleinau, G., Muttenthaler, M., Stoev, S., Manning, M., Bibic, L., . . . Chini, B. (2016). Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure. JOURNAL OF MEDICINAL CHEMISTRY, 59(15), 7152-7166. doi:10.1021/acs.jmedchem.6b00564DOI: 10.1021/acs.jmedchem.6b00564
The chemokine receptor CXCR4 and the cannabinoid receptor CB2R form heterodimers in non-Hodgkin lymphoma (NHL) and solid tumors leading to functional crosstalk (Conference Paper)
Guerrero, M., Griera, R., Perez, M., Roue, G., Bosch, J., McCormick, P. J., . . . Perez-Galan, P. (2016). The chemokine receptor CXCR4 and the cannabinoid receptor CB2R form heterodimers in non-Hodgkin lymphoma (NHL) and solid tumors leading to functional crosstalk. In CANCER RESEARCH Vol. 76. doi:10.1158/1538-7445.AM2016-3288DOI: 10.1158/1538-7445.AM2016-3288
A Significant Role of the Truncated Ghrelin Receptor GHS-R1b in Ghrelin-induced Signaling in Neurons (Journal article)
Navarro, G., Aguinaga, D., Angelats, E., Medrano, M., Moreno, E., Mallol, J., . . . Ferre, S. (2016). A Significant Role of the Truncated Ghrelin Receptor GHS-R1b in Ghrelin-induced Signaling in Neurons. JOURNAL OF BIOLOGICAL CHEMISTRY, 291(25), 13048-13062. doi:10.1074/jbc.M116.715144DOI: 10.1074/jbc.M116.715144
Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with G<sub>i</sub> and G<sub>s</sub> (Journal article)
Navarro, G., Cordomi, A., Zelman-Femiak, M., Brugarolas, M., Moreno, E., Aguinaga, D., . . . Franco, R. (2016). Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with G<sub>i</sub> and G<sub>s</sub>. BMC BIOLOGY, 14. doi:10.1186/s12915-016-0247-4DOI: 10.1186/s12915-016-0247-4
Revealing G-protein-coupled receptor oligomerization at the single-molecule level through a nanoscopic lens: methods, dynamics and biological function (Journal article)
Scarselli, M., Annibale, P., McCormick, P. J., Kolachalam, S., Aringhieri, S., Radenovic, A., . . . Maggio, R. (2016). Revealing G-protein-coupled receptor oligomerization at the single-molecule level through a nanoscopic lens: methods, dynamics and biological function. FEBS JOURNAL, 283(7), 1197-1217. doi:10.1111/febs.13577DOI: 10.1111/febs.13577
Adenosine deaminase regulates T<sub>reg</sub> expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1 (Journal article)
Naval-Macabuhay, I., Casanova, V., Navarro, G., Garcia, F., Leon, A., Miralles, L., . . . Climent, N. (2016). Adenosine deaminase regulates T<sub>reg</sub> expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1. JOURNAL OF LEUKOCYTE BIOLOGY, 99(2), 349-359. doi:10.1189/jlb.3A1214-580RRDOI: 10.1189/jlb.3A1214-580RR
2015
Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling (Journal article)
Marada, S., Navarro, G., Truong, A., Stewart, D. P., Arensdorf, A. M., Nachtergaele, S., . . . Ogden, S. K. (2015). Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling. PLOS GENETICS, 11(8). doi:10.1371/journal.pgen.1005473DOI: 10.1371/journal.pgen.1005473
INSULIN GROWTH FACTOR I AND ITS RECEPTOR ARE ANTAGONISTIC MODULATORS OF GLUCOSE HANDLING BY ASTROCYTES (Preprint)
DOI: 10.1101/023556
Role of Cannabinoid Receptor CB<sub>2</sub> in HER2 Pro-oncogenic Signaling in Breast Cancer (Journal article)
Perez-Gomez, E., Andradas, C., Blasco-Benito, S., Caffarel, M. M., Garcia-Taboada, E., Villa-Morales, M., . . . Sanchez, C. (2015). Role of Cannabinoid Receptor CB<sub>2</sub> in HER2 Pro-oncogenic Signaling in Breast Cancer. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 107(6). doi:10.1093/jnci/djv077DOI: 10.1093/jnci/djv077
Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine (Journal article)
Navarro, G., Quiroz, C., Moreno-Delgado, D., Sierakowiak, A., McDowell, K., Moreno, E., . . . McCormick, P. J. (2015). Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine. JOURNAL OF NEUROSCIENCE, 35(17), 6639-6653. doi:10.1523/JNEUROSCI.4364-14.2015DOI: 10.1523/JNEUROSCI.4364-14.2015
Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB<sub>1</sub> and Serotonin 5-HT<sub>2A</sub> Receptors (Journal article)
Vinals, X., Moreno, E., Lanfumey, L., Cordomi, A., Pastor, A., de La Torre, R., . . . Robledo, P. (2015). Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB<sub>1</sub> and Serotonin 5-HT<sub>2A</sub> Receptors. PLOS BIOLOGY, 13(7). doi:10.1371/journal.pbio.1002194DOI: 10.1371/journal.pbio.1002194
2014
Intracellular Calcium Levels Determine Differential Modulation of Allosteric Interactions within G Protein-Coupled Receptor Heteromers (Journal article)
Navarro, G., Aguinaga, D., Moreno, E., Hradsky, J., Reddy, P. P., Cortes, A., . . . Ferre, S. (2014). Intracellular Calcium Levels Determine Differential Modulation of Allosteric Interactions within G Protein-Coupled Receptor Heteromers. CHEMISTRY & BIOLOGY, 21(11), 1546-1556. doi:10.1016/j.chembiol.2014.10.004DOI: 10.1016/j.chembiol.2014.10.004
Functional Selectivity of Allosteric Interactions within G Protein-Coupled Receptor Oligomers: The Dopamine D<sub>1</sub>-D<sub>3</sub> Receptor Heterotetramer (Journal article)
Guitart, X., Navarro, G., Moreno, E., Yano, H., Cai, N. -S., Sanchez-Soto, M., . . . Ferre, S. (2014). Functional Selectivity of Allosteric Interactions within G Protein-Coupled Receptor Oligomers: The Dopamine D<sub>1</sub>-D<sub>3</sub> Receptor Heterotetramer. MOLECULAR PHARMACOLOGY, 86(4), 417-429. doi:10.1124/mol.114.093096DOI: 10.1124/mol.114.093096
TARGETING DOPAMINE D1-HISTAMINE H3 RECEPTOR HETEROMERS AS A THERAPEUTICAL STRATEGY TO PREVENT COGNITIVE DEFICITS AND NEURODEGENERATION IN HUNTINGTON'S DISEASE (Conference Paper)
Canadell, M. P., Moreno-Delgado, D., Rodriguez-Ruiz, M., Moreno, E., Botta, J., Gasperini, P., . . . Gines, S. (2014). TARGETING DOPAMINE D1-HISTAMINE H3 RECEPTOR HETEROMERS AS A THERAPEUTICAL STRATEGY TO PREVENT COGNITIVE DEFICITS AND NEURODEGENERATION IN HUNTINGTON'S DISEASE. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 85 (pp. A100). doi:10.1136/jnnp-2014-309032.289DOI: 10.1136/jnnp-2014-309032.289
Targeting CB<sub>2</sub>-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling (Journal article)
Moreno, E., Andradas, C., Medrano, M., Caffarel, M. M., Perez-Gomez, E., Blasco-Benito, S., . . . Sanchez, C. (2014). Targeting CB<sub>2</sub>-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY, 289(32), 21960-21972. doi:10.1074/jbc.M114.561761DOI: 10.1074/jbc.M114.561761
Telomerase Variant A279T Induces Telomere Dysfunction and Inhibits Non-Canonical Telomerase Activity in Esophageal Carcinomas (Journal article)
Zhang, Y., Calado, R., Rao, M., Hong, J. A., Meeker, A. K., Dumitriu, B., . . . Schrump, D. S. (2014). Telomerase Variant A279T Induces Telomere Dysfunction and Inhibits Non-Canonical Telomerase Activity in Esophageal Carcinomas. PLOS ONE, 9(7). doi:10.1371/journal.pone.0101010DOI: 10.1371/journal.pone.0101010
L-DOPA-treatment in primates disrupts the expression of A<sub>2A</sub> adenosine-CB<sub>1</sub> cannabinoid-D<sub>2</sub> dopamine receptor heteromers in the caudate nucleus (Journal article)
Bonaventura, J., Rico, A. J., Moreno, E., Sierra, S., Sanchez, M., Luquin, N., . . . Franco, R. (2014). L-DOPA-treatment in primates disrupts the expression of A<sub>2A</sub> adenosine-CB<sub>1</sub> cannabinoid-D<sub>2</sub> dopamine receptor heteromers in the caudate nucleus. NEUROPHARMACOLOGY, 79, 90-100. doi:10.1016/j.neuropharm.2013.10.036DOI: 10.1016/j.neuropharm.2013.10.036
Cocaine Disrupts Histamine H<sub>3</sub> Receptor Modulation of Dopamine D<sub>1</sub> Receptor Signaling: σ<sub>1</sub>-D<sub>1</sub>-H<sub>3</sub> Receptor Complexes as Key Targets for Reducing Cocaine's Effects (Journal article)
Moreno, E., Moreno-Delgado, D., Navarro, G., Hoffmann, H. M., Fuentes, S., Rosell-Vilar, S., . . . McCormick, P. J. (2014). Cocaine Disrupts Histamine H<sub>3</sub> Receptor Modulation of Dopamine D<sub>1</sub> Receptor Signaling: σ<sub>1</sub>-D<sub>1</sub>-H<sub>3</sub> Receptor Complexes as Key Targets for Reducing Cocaine's Effects. JOURNAL OF NEUROSCIENCE, 34(10), 3545-3558. doi:10.1523/JNEUROSCI.4147-13.2014DOI: 10.1523/JNEUROSCI.4147-13.2014
L-DOPA disrupts adenosine A<sub>2A</sub>-cannabinoid CB<sub>1</sub>-dopamine D<sub>2</sub> receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies (Journal article)
Pinna, A., Bonaventura, J., Farre, D., Sanchez, M., Simola, N., Mallol, J., . . . Franco, R. (2014). L-DOPA disrupts adenosine A<sub>2A</sub>-cannabinoid CB<sub>1</sub>-dopamine D<sub>2</sub> receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies. EXPERIMENTAL NEUROLOGY, 253, 180-191. doi:10.1016/j.expneurol.2013.12.021DOI: 10.1016/j.expneurol.2013.12.021
Allosteric communication between Gi and Gs in the adenosine A1-A<sub>2A</sub> receptor tetrameric complex (Conference Paper)
Franco, R., Cordomi, A., Zelman-Femiak, M., Brugarolas, M., Moreno, E., Cortes, A., . . . Navarro, G. (2014). Allosteric communication between Gi and Gs in the adenosine A1-A<sub>2A</sub> receptor tetrameric complex. In PURINERGIC SIGNALLING Vol. 10 (pp. 738). Retrieved from https://www.webofscience.com/
Evidence for adenosine A<sub>1</sub>-A<sub>2A</sub> receptor heteromers in neurons and astrocytes (Conference Paper)
Navarro, G., Cordom, A., Zelman-Femiak, M., Brugarolas, M., Aguinaga, D., Medrano, M., . . . Franco, R. (2014). Evidence for adenosine A<sub>1</sub>-A<sub>2A</sub> receptor heteromers in neurons and astrocytes. In PURINERGIC SIGNALLING Vol. 10 (pp. 738). Retrieved from https://www.webofscience.com/
INVESTIGATION OF THE DIMERIZATION INTERFACE OF THE SEROTONIN 5-HT<sub>2A</sub> RECEPTOR BY COMPUTATIONAL AND EXPERIMENTAL APPROACHES (Conference Paper)
de la Fuente Gonzalez, R. A., Garcia Silva, A., Moreno Guillen, E., McCormick, P. J., Marti Solano, M., Cadavid, T. M. I., . . . Castro Perez, M. (2014). INVESTIGATION OF THE DIMERIZATION INTERFACE OF THE SEROTONIN 5-HT<sub>2A</sub> RECEPTOR BY COMPUTATIONAL AND EXPERIMENTAL APPROACHES. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 115 (pp. 49). Retrieved from https://www.webofscience.com/
2013
A<sub>1</sub>R-A<sub>2A</sub>R heteromers coupled to G<sub>s</sub> and G<sub>i/0</sub> proteins modulate GABA transport into astrocytes (Journal article)
Cristovao-Ferreira, S., Navarro, G., Brugarolas, M., Perez-Capote, K., Vaz, S. H., Fattorini, G., . . . Sebastiao, A. M. (2013). A<sub>1</sub>R-A<sub>2A</sub>R heteromers coupled to G<sub>s</sub> and G<sub>i/0</sub> proteins modulate GABA transport into astrocytes. PURINERGIC SIGNALLING, 9(3), 433-449. doi:10.1007/s11302-013-9364-5DOI: 10.1007/s11302-013-9364-5
Homodimerization of adenosine A<sub>1</sub> receptors in brain cortex explains the biphasic effects of caffeine (Journal article)
Gracia, E., Moreno, E., Cortes, A., Lluis, C., Mallol, J., McCormick, P. J., . . . Casado, V. (2013). Homodimerization of adenosine A<sub>1</sub> receptors in brain cortex explains the biphasic effects of caffeine. NEUROPHARMACOLOGY, 71, 56-69. doi:10.1016/j.neuropharm.2013.03.005DOI: 10.1016/j.neuropharm.2013.03.005
Cocaine Inhibits Dopamine D<sub>2</sub> Receptor Signaling via Sigma-1-D<sub>2</sub> Receptor Heteromers (Journal article)
Navarro, G., Moreno, E., Bonaventura, J., Brugarolas, M., Farre, D., Aguinaga, D., . . . McCormick, P. J. (2013). Cocaine Inhibits Dopamine D<sub>2</sub> Receptor Signaling via Sigma-1-D<sub>2</sub> Receptor Heteromers. PLOS ONE, 8(4). doi:10.1371/journal.pone.0061245DOI: 10.1371/journal.pone.0061245
The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors (Journal article)
Gracia, E., Farre, D., Cortes, A., Ferrer-Costa, C., Orozco, M., Mallol, J., . . . Casado, V. (2013). The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors. FASEB JOURNAL, 27(3), 1048-1061. doi:10.1096/fj.12-212621DOI: 10.1096/fj.12-212621
Modulation of GABA Transport by Adenosine A<sub>1</sub>R-A<sub>2A</sub>R Heteromers, Which Are Coupled to Both G<sub>s</sub>- and G<sub>i/o</sub>-Proteins (Retraction of vol 31, pg 15629, 2011) (Journal article)
Cristovao-Ferreira, S., Navarro, G., Brugarolas, M., Perez-Capote, K., Vaz, S. H., Fattorini, G., . . . Sebastiao, A. M. (2013). Modulation of GABA Transport by Adenosine A<sub>1</sub>R-A<sub>2A</sub>R Heteromers, Which Are Coupled to Both G<sub>s</sub>- and G<sub>i/o</sub>-Proteins (Retraction of vol 31, pg 15629, 2011). JOURNAL OF NEUROSCIENCE, 33(3), 1292. doi:10.1523/JNEUROSCI.5705-12.2013DOI: 10.1523/JNEUROSCI.5705-12.2013
Challenges in the Development of Heteromer-GPCR-Based Drugs (Chapter)
Franco, R., Martinez-Pinilla, E., Ricobaraza, A., & McCormick, P. J. (2013). Challenges in the Development of Heteromer-GPCR-Based Drugs. In OLIGOMERIZATION IN HEALTH AND DISEASE (Vol. 117, pp. 143-162). doi:10.1016/B978-0-12-386931-9.00006-4DOI: 10.1016/B978-0-12-386931-9.00006-4
Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology. (Journal article)
Navarro, G., McCormick, P. J., Mallol, J., Lluís, C., Franco, R., Cortés, A., . . . Ferré, S. (2013). Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology.. Methods in molecular biology (Clifton, N.J.), 964, 95-105. doi:10.1007/978-1-62703-251-3_7DOI: 10.1007/978-1-62703-251-3_7
2012
Adenosine Deaminase Enhances the Immunogenicity of Human Dendritic Cells from Healthy and HIV-Infected Individuals (Journal article)
Casanova, V., Naval-Macabuhay, I., Massanella, M., Rodriguez-Garcia, M., Blanco, J., Gatell, J. M., . . . McCormick, P. J. (2012). Adenosine Deaminase Enhances the Immunogenicity of Human Dendritic Cells from Healthy and HIV-Infected Individuals. PLOS ONE, 7(12). doi:10.1371/journal.pone.0051287DOI: 10.1371/journal.pone.0051287
Loading dendritic cells from HIV-1 infected patients with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specific T cell responses (Conference Paper)
Climent, N., Munier, S., Pique, N., Garcia, F., Pavot, V., Leon, A., . . . Gallart, T. (2012). Loading dendritic cells from HIV-1 infected patients with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specific T cell responses. In RETROVIROLOGY Vol. 9. doi:10.1186/1742-4690-9-S2-P247DOI: 10.1186/1742-4690-9-S2-P247
Unmasking adenosine 2A receptors (A<sub>2A</sub>Rs) in monkey basal ganglia output neurons using cholera toxin subunit B (CTB) (Journal article)
Luquin, N., Sierra, S., Rico, A. J., Gomez-Bautista, V., Roda, E., Conte-Perales, L., . . . Lanciego, J. L. (2012). Unmasking adenosine 2A receptors (A<sub>2A</sub>Rs) in monkey basal ganglia output neurons using cholera toxin subunit B (CTB). NEUROBIOLOGY OF DISEASE, 47(3), 347-357. doi:10.1016/j.nbd.2012.05.006DOI: 10.1016/j.nbd.2012.05.006
Cannabinoid Receptors CB<sub>1</sub> and CB<sub>2</sub> Form Functional Heteromers in Brain (Journal article)
Callen, L., Moreno, E., Barroso-Chinea, P., Moreno-Delgado, D., Cortes, A., Mallol, J., . . . McCormick, P. J. (2012). Cannabinoid Receptors CB<sub>1</sub> and CB<sub>2</sub> Form Functional Heteromers in Brain. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(25), 20851-20865. doi:10.1074/jbc.M111.335273DOI: 10.1074/jbc.M111.335273
Dopamine D<sub>4</sub> receptor, but not the ADHD-associated D<sub>4.7</sub> variant, forms functional heteromers with the dopamine D<sub>2S</sub> receptor in the brain (Journal article)
Gonzalez, S., Rangel-Barajas, C., Peper, M., Lorenzo, R., Moreno, E., Ciruela, F., . . . Ferre, S. (2012). Dopamine D<sub>4</sub> receptor, but not the ADHD-associated D<sub>4.7</sub> variant, forms functional heteromers with the dopamine D<sub>2S</sub> receptor in the brain. MOLECULAR PSYCHIATRY, 17(6), 650-662. doi:10.1038/mp.2011.93DOI: 10.1038/mp.2011.93
NCS-1 associates with adenosine A<sub>2A</sub> receptors and modulates receptor function (Journal article)
Navarro, G., Hradsky, J., Lluis, C., Casado, V., McCormick, P. J., Kreutz, M. R., & Mikhaylova, M. (2012). NCS-1 associates with adenosine A<sub>2A</sub> receptors and modulates receptor function. FRONTIERS IN MOLECULAR NEUROSCIENCE, 5. doi:10.3389/fnmol.2012.00053DOI: 10.3389/fnmol.2012.00053
Kaposi Sarcoma Herpesvirus Promotes Endothelial-to-Mesenchymal Transition through Notch-Dependent Signaling (Journal article)
Gasperini, P., Espigol-Frigole, G., McCormick, P. J., Salvucci, O., Maric, D., Uldrick, T. S., . . . Tosato, G. (2012). Kaposi Sarcoma Herpesvirus Promotes Endothelial-to-Mesenchymal Transition through Notch-Dependent Signaling. CANCER RESEARCH, 72(5), 1157-1169. doi:10.1158/0008-5472.CAN-11-3067DOI: 10.1158/0008-5472.CAN-11-3067
Circadian-Related Heteromerization of Adrenergic and Dopamine D<sub>4</sub> Receptors Modulates Melatonin Synthesis and Release in the Pineal Gland (Journal article)
Gonzalez, S., Moreno-Delgado, D., Moreno, E., Perez-Capote, K., Franco, R., Mallol, J., . . . McCormick, P. J. (2012). Circadian-Related Heteromerization of Adrenergic and Dopamine D<sub>4</sub> Receptors Modulates Melatonin Synthesis and Release in the Pineal Gland. PLOS BIOLOGY, 10(6). doi:10.1371/journal.pbio.1001347DOI: 10.1371/journal.pbio.1001347
2011
Modulation of GABA Transport by Adenosine A<sub>1</sub>R-A<sub>2A</sub>R Heteromers, Which Are Coupled to Both G<sub>s</sub>- and G<sub>i/o</sub>-Proteins (Retracted article. See vol. 33, pg. 1292, 2013) (Journal article)
Cristovao-Ferreira, S., Navarro, G., Brugarolas, M., Perez-Capote, K., Vaz, S. H., Fattorini, G., . . . Sebastiao, A. M. (2011). Modulation of GABA Transport by Adenosine A<sub>1</sub>R-A<sub>2A</sub>R Heteromers, Which Are Coupled to Both G<sub>s</sub>- and G<sub>i/o</sub>-Proteins (Retracted article. See vol. 33, pg. 1292, 2013). JOURNAL OF NEUROSCIENCE, 31(44), 15629-15639. doi:10.1523/JNEUROSCI.2526-11.2011DOI: 10.1523/JNEUROSCI.2526-11.2011
Post-translational Membrane Insertion of Tail-anchored Transmembrane EF-hand Ca<SUP>2+</SUP> Sensor Calneurons Requires the TRC40/Asna1 Protein Chaperone (Journal article)
Hradsky, J., Raghuram, V., Reddy, P. P., Navarro, G., Hupe, M., Casado, V., . . . Mikhaylova, M. (2011). Post-translational Membrane Insertion of Tail-anchored Transmembrane EF-hand Ca<SUP>2+</SUP> Sensor Calneurons Requires the TRC40/Asna1 Protein Chaperone. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(42), 36762-36776. doi:10.1074/jbc.M111.280339DOI: 10.1074/jbc.M111.280339
Dopamine-Galanin Receptor Heteromers Modulate Cholinergic Neurotransmission in the Rat Ventral Hippocampus (Journal article)
Moreno, E., Vaz, S. H., Cai, N. -S., Ferrada, C., Quiroz, C., Barodia, S. K., . . . Ferre, S. (2011). Dopamine-Galanin Receptor Heteromers Modulate Cholinergic Neurotransmission in the Rat Ventral Hippocampus. JOURNAL OF NEUROSCIENCE, 31(20), 7412-7423. doi:10.1523/JNEUROSCI.0191-11.2011DOI: 10.1523/JNEUROSCI.0191-11.2011
Biotin Ergopeptide Probes for Dopamine Receptors (Journal article)
Vendrell, M., Molero, A., Gonzalez, S., Perez-Capote, K., Lluis, C., McCormick, P. J., . . . Royo, M. (2011). Biotin Ergopeptide Probes for Dopamine Receptors. JOURNAL OF MEDICINAL CHEMISTRY, 54(4), 1080-1090. doi:10.1021/jm101566dDOI: 10.1021/jm101566d
Dopamine D<sub>1</sub>-histamine H<sub>3</sub> Receptor Heteromers Provide a Selective Link to MAPK Signaling in GABAergic Neurons of the Direct Striatal Pathway (Journal article)
Moreno, E., Hoffmann, H., Gonzalez-Sepulveda, M., Navarro, G., Casado, V., Cortes, A., . . . Franco, R. (2011). Dopamine D<sub>1</sub>-histamine H<sub>3</sub> Receptor Heteromers Provide a Selective Link to MAPK Signaling in GABAergic Neurons of the Direct Striatal Pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(7), 5846-5854. doi:10.1074/jbc.M110.161489DOI: 10.1074/jbc.M110.161489
2010
Direct involvement of σ-1 receptors in the dopamine D<sub>1</sub> receptor-mediated effects of cocaine (Journal article)
Navarro, G., Moreno, E., Aymerich, M., Marcellino, D., McCormick, P. J., Mallol, J., . . . Franco, R. (2010). Direct involvement of σ-1 receptors in the dopamine D<sub>1</sub> receptor-mediated effects of cocaine. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(43), 18676-18681. doi:10.1073/pnas.1008911107DOI: 10.1073/pnas.1008911107
The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1 (Journal article)
Sierra, M. D. L. L., Sakakibara, S., Gasperini, P., Salvucci, O., Jiang, K., McCormick, P. J., . . . Tosato, G. (2010). The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1. BLOOD, 115(19), 3970-3979. doi:10.1182/blood-2009-10-246967DOI: 10.1182/blood-2009-10-246967
2009
Impaired Recruitment of Grk6 and β-Arrestin2 Causes Delayed Internalization and Desensitization of a WHIM Syndrome-Associated CXCR4 Mutant Receptor (Journal article)
McCormick, P. J., Segarra, M., Gasperini, P., Gulino, A. V., & Tosato, G. (2009). Impaired Recruitment of Grk6 and β-Arrestin2 Causes Delayed Internalization and Desensitization of a WHIM Syndrome-Associated CXCR4 Mutant Receptor. PLOS ONE, 4(12). doi:10.1371/journal.pone.0008102DOI: 10.1371/journal.pone.0008102
2008
Palmitoylation Controls Recycling in Lysosomal Sorting and Trafficking (Journal article)
McCormick, P. J., Dumaresq-Doiron, K., Pluviose, A. -S., Pichette, V., Tosato, G., & Lefrancois, S. (2008). Palmitoylation Controls Recycling in Lysosomal Sorting and Trafficking. TRAFFIC, 9(11), 1984-1997. doi:10.1111/j.1600-0854.2008.00814.xDOI: 10.1111/j.1600-0854.2008.00814.x
Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth (Journal article)
Segarra, M., Williams, C. K., Sierra, M. D. L. L., Bernardo, M., McCormick, P. J., Maric, D., . . . Tosato, G. (2008). Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth. BLOOD, 112(5), 1904-1911. doi:10.1182/blood-2007-11-126045DOI: 10.1182/blood-2007-11-126045
CD1a and MHC class I follow a similar endocytic recycling pathway (Journal article)
Barral, D. C., Cavallari, M., McCormick, P. J., Garg, S., Magee, A. I., Bonifacino, J. S., . . . Brenner, M. B. (2008). CD1a and MHC class I follow a similar endocytic recycling pathway. TRAFFIC, 9(9), 1446-1457. doi:10.1111/j.1600-0854.2008.00781.xDOI: 10.1111/j.1600-0854.2008.00781.x
2007
The Arf GEF GBF1 is required for GGA recruitment to golgi membranes (Journal article)
Lefrancois, S., & McCormick, P. J. (2007). The Arf GEF GBF1 is required for GGA recruitment to golgi membranes. TRAFFIC, 8(10), 1440-1451. doi:10.1111/j.1600-0854.2007.00623.xDOI: 10.1111/j.1600-0854.2007.00623.x
Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells (Journal article)
Sierra, M. D. L. L., Gasperini, P., McCormick, P. J., Zhu, J., & Tosato, G. (2007). Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells. BLOOD, 110(7), 2276-2285. doi:10.1182/blood-2007-03-081448DOI: 10.1182/blood-2007-03-081448
Sec61α and TRAM are sequentially adjacent to a nascent viral membrane protein during its ER integration (Journal article)
Sauri, A., McCormick, P. J., Johnson, A. E., & Mingarro, I. (2007). Sec61α and TRAM are sequentially adjacent to a nascent viral membrane protein during its ER integration. JOURNAL OF MOLECULAR BIOLOGY, 366(2), 366-374. doi:10.1016/j.jmb.2006.11.052DOI: 10.1016/j.jmb.2006.11.052
2006
EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling (Journal article)
Salvucci, O., Sierra, M. D. L. L., Martina, J. A., McCormick, P. J., & Tosato, G. (2006). EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling. BLOOD, 108(9), 2914-2922. doi:10.1182/blood-2006-05-023341DOI: 10.1182/blood-2006-05-023341
2005
Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments (Journal article)
McCormick, P. J., Martina, J. A., & Bonifacino, J. S. (2005). Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(22), 7910-7915. doi:10.1073/pnas.0502206102DOI: 10.1073/pnas.0502206102
2004
Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins (Journal article)
Woolhead, C. A., McCormick, P. J., & Johnson, A. E. (2004). Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins. CELL, 116(5), 725-736. doi:10.1016/S0092-8674(04)00169-2DOI: 10.1016/S0092-8674(04)00169-2
2003
Cotranslational protein integration into the ER membrane is mediated by the binding of nascent chains to translocon proteins (Journal article)
McCormick, P. J., Miao, Y. W., Shao, Y. L., Lin, J. L., & Johnson, A. E. (2003). Cotranslational protein integration into the ER membrane is mediated by the binding of nascent chains to translocon proteins. MOLECULAR CELL, 12(2), 329-341. doi:10.1016/S1097-2765(03)00304-6DOI: 10.1016/S1097-2765(03)00304-6
