2024
Tatham, L., Sharp, J., Neary, M., Herriott, J., Kijak, E., Gallardo-Toledo, E., . . . Owen, A. (2024). Sotrovimab Lacks Efficacy in Treatment of Syrian Golden Hamsters Infected With SARS-CoV-2 BQ.1.1. Poster session presented at the meeting of The 31st Conference on Retroviruses and Opportunistic Infections (CROI 2024). Denver, US.
2023
Box, H. J., Sharp, J., Pennington, S. H., Kijak, E., Tatham, L., Caygill, C. H., . . . Owen, A. (2023). Lack of antiviral activity of probenecid in vitro and in Syrian golden hamsters.. The Journal of antimicrobial chemotherapy, dkad362. doi:10.1093/jac/dkad362DOI: 10.1093/jac/dkad362
Gallardo-Toledo, E., Neary, M., Sharp, J., Herriott, J., Kijak, E., Bramwell, C., . . . Owen, A. (2023). Chemoprophylactic Assessment of Combined Intranasal SARS-CoV-2 Polymerase and Exonuclease Inhibition in Syrian Golden Hamsters.. Viruses, 15(11), 2161. doi:10.3390/v15112161DOI: 10.3390/v15112161
Neary, M., Sharp, J., Gallardo-Toledo, E., Herriott, J., Kijak, E., Bramwell, C., . . . Owen, A. (2023). Evaluation of Nafamostat as Chemoprophylaxis for SARS-CoV-2 Infection in Hamsters. VIRUSES-BASEL, 15(8). doi:10.3390/v15081744DOI: 10.3390/v15081744
Neary, M., Arshad, U., Tatham, L., Pertinez, H., Box, H., Rajoli, R. K. R., . . . Owen, A. (2023). Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1228. doi:10.1016/j.jchromb.2023.123823DOI: 10.1016/j.jchromb.2023.123823
Curley, P., Hobson, J. J., Liptrott, N. J., Makarov, E., Al-Khouja, A., Tatham, L., . . . Owen, A. (2023). Preclinical Evaluation of Long-Acting Emtricitabine Semi-Solid Prodrug Nanoparticle Formulations.. Pharmaceutics, 15(7), 1835. doi:10.3390/pharmaceutics15071835DOI: 10.3390/pharmaceutics15071835
Gaynor, K. U. U., Vaysburd, M., Harman, M. A. J., Albecka, A., Jeffrey, P., Beswick, P., . . . James, L. C. C. (2023). Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2. NATURE COMMUNICATIONS, 14(1). doi:10.1038/s41467-023-39158-1DOI: 10.1038/s41467-023-39158-1
Elbaz, N. M., Tatham, L. M., Owen, A., Rannard, S., & McDonald, T. O. (2023). Layer by layer self-assembly for coating a nanosuspension to modify drug release and stability for oral delivery. Food Hydrocolloids, 108908. doi:10.1016/j.foodhyd.2023.108908DOI: 10.1016/j.foodhyd.2023.108908
Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case. (Preprint)
DOI: 10.1101/2022.01.23.477397
Brevini, T., Maes, M., Webb, G. J., John, B. V., Fuchs, C. D., Buescher, G., . . . Sampaziotis, F. (2023). FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2. NATURE, 615(7950), 134-+. doi:10.1038/s41586-022-05594-0DOI: 10.1038/s41586-022-05594-0
2022
Lack of antiviral activity of probenecid in Vero E6 cells and Syrian golden hamsters: a need for better understanding of inter-lab differences in preclinical assays. (Preprint)
DOI: 10.1101/2022.03.03.482788
2021
Elbaz, N. M., Tatham, L. M., Owen, A., Rannard, S., & McDonald, T. O. (2021). Redispersible nanosuspensions as a plausible oral delivery system for curcumin. Food Hydrocolloids, 121, 107005. doi:10.1016/j.foodhyd.2021.107005DOI: 10.1016/j.foodhyd.2021.107005
Hobson, J. J., Savage, A. C., Dwyer, A., Unsworth, C., Massam, J., Arshad, U., . . . Rannard, S. (n.d.). Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection. Nanoscale. doi:10.1039/d1nr00309gDOI: 10.1039/d1nr00309g
Rajoli, R. K. R., Pertinez, H., Arshad, U., Box, H., Tatham, L., Curley, P., . . . Owen, A. (2021). Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(4), 2078-2088. doi:10.1111/bcp.14619DOI: 10.1111/bcp.14619
Hobson, J., Savage, A., Dwyer, A., Unsworth, C., Arshad, U., Pertinez, H., . . . Rannard, S. (2021). Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection. doi:10.26434/chemrxiv.13587035DOI: 10.26434/chemrxiv.13587035
Hobson, J., Savage, A., Dwyer, A., Unsworth, C., Arshad, U., Pertinez, H., . . . Rannard, S. (2021). Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection. doi:10.26434/chemrxiv.13587035.v1DOI: 10.26434/chemrxiv.13587035.v1
2020
Elkateb, H., Tatham, L. M., Cauldbeck, H., Niezabitowska, E., Owen, A., Rannard, S., & McDonald, T. (n.d.). Optimization of the Synthetic Parameters of Lipid Polymer Hybrid Nanoparticles Dual Loaded with Darunavir and Ritonavir for the Treatment of HIV. International Journal of Pharmaceutics, 119794. doi:10.1016/j.ijpharm.2020.119794DOI: 10.1016/j.ijpharm.2020.119794
Arshad, U., Pertinez, H., Box, H., Tatham, L., Rajoli, R. K., Curley, P., . . . Owen, A. (2020). Prioritisation of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics.. Clinical pharmacology and therapeutics. doi:10.1002/cpt.1909DOI: 10.1002/cpt.1909
Rajoli, R. K., Pertinez, H., Arshad, U., Box, H., Tatham, L., Curley, P., . . . Owen, A. (2020). Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis.. medRxiv : the preprint server for health sciences. doi:10.1101/2020.05.01.20087130DOI: 10.1101/2020.05.01.20087130
Arshad, U., Pertinez, H., Box, H., Tatham, L., Rajoli, R. K. R., Curley, P., . . . Owen, A. (2020). Prioritisation of potential anti-SARS-CoV-2 drug repurposing opportunities based on ability to achieve adequate plasma and target site concentrations derived from their established human pharmacokinetics. doi:10.1101/2020.04.16.20068379DOI: 10.1101/2020.04.16.20068379
2019
Tatham, L. M., Liptrott, N. J., Rannard, S. P., & Owen, A. (2019). Long-Acting Injectable Statins-Is It Time for a Paradigm Shift?. MOLECULES, 24(15). doi:10.3390/molecules24152685DOI: 10.3390/molecules24152685
Savage, A. C., Tatham, L. M., Siccardi, M., Scott, T., Vourvahis, M., Clark, A., . . . Owen, A. (2019). Improving maraviroc oral bioavailability by formation of solid drug nanoparticles. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 138, 30-36. doi:10.1016/j.ejpb.2018.05.015DOI: 10.1016/j.ejpb.2018.05.015
Tatham, L. M., Savage, A. C., Dwyer, A., Siccardi, M., Scott, T., Vourvahis, M., . . . Owen, A. (2019). Towards a Maraviroc long-acting injectable nanoformulation. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 138, 92-98. doi:10.1016/j.ejpb.2018.04.009DOI: 10.1016/j.ejpb.2018.04.009
2018
Direct synthesis of nanoparticles with spatial heterogeneity for tailored cellular interactions (Conference Paper)
Hern, F. Y., Tatham, L., Owen, A., & Rannard, S. (2018). Direct synthesis of nanoparticles with spatial heterogeneity for tailored cellular interactions. In 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond Vol. 256. Boston, MA.
Tatham, L., Savage, A. C., Dwyer, A. B., Siccardi, M., Scott, T., Vourvahis, M., . . . Owen, A. (2018). Maraviroc solid drug nanoparticles with improved oral pharmacokinetics. In CROI. Boston MA.
Tatham, L., Dwyer, A. B., Savage, A. C., Siccardi, M., Scott, T., Vourvahis, M., . . . Owen, A. (2018). Towards a Long-Acting Injectable (LAI) Formulation For Maraviroc. In CROI. Boston MA.
Preclinical evaluation of reduced dose darunavir/ritonavir nanoparticle formulation. (Conference Paper)
Box, H., Sharp, J., Neary, M. G., Moss, D., Tatham, L., Savage, A., . . . Owen, A. (n.d.). Preclinical evaluation of reduced dose darunavir/ritonavir nanoparticle formulation.. In CROI. Boston, MA, USA.
Bakshi, R. P., Tatham, L. M., Savage, A. C., Tripathi, A. K., Mlambo, G., Ippolito, M. M., . . . Shapiro, T. A. (2018). Long-acting injectable atovaquone nanomedicines for malaria prophylaxis. Nature Communications, 9. doi:10.1038/s41467-017-02603-zDOI: 10.1038/s41467-017-02603-z
Hern, F., Tatham, L., Owen, A., & Rannard, S. (2018). Direct synthesis of nanoparticles with spatial heterogeneity for tailored cellular interactions. Retrieved from https://www.webofscience.com/
LONG-ACTING INJECTABLE ATOVAQUONE NANOMEDICINES FOR MALARIA PROPHYLAXIS (Conference Paper)
Bakshi, R., Tatham, L., Savage, A., Tripathi, A., Mlambo, G., Ippolito, M., . . . Shapiro, T. (2018). LONG-ACTING INJECTABLE ATOVAQUONE NANOMEDICINES FOR MALARIA PROPHYLAXIS. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 99 (pp. 94). Retrieved from https://www.webofscience.com/
2017
Tatham, L., Savage, A., Rannard, S., & Owen, A. (2017). Maraviroc Solid Drug Nanoparticles with Improved Oral Pharmacokinetics. In British Society for Nanomedicine. Queens University Belfast.
Long acting injectable formulations of atovaquone for malaria prophylaxis (Conference Paper)
Savage, A., Tatham, L., Bakshi, R., Tripathi, A., Mlambo, G., Shapiro, T., . . . Rannard, S. (2017). Long acting injectable formulations of atovaquone for malaria prophylaxis. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 254. Retrieved from https://www.webofscience.com/
2016
Tatham, L., Ford, J., Rogers, H., Rannard, S., & Owen, A. (2016). Surface-Dependent Mechanism for Transcellular Permeation of Polymeric Nanoparticles Across Intestinal Monolayers. In Controlled Release Society Annual Meeting & Exposition. Seattle, Washington.
Handbook of Immunological Properties of Engineered Nanomaterials (Chapter)
Dobrovolskaia, M. A., & McNeil, S. E. (n.d.). Handbook of Immunological Properties of Engineered Nanomaterials. WORLD SCIENTIFIC. doi:10.1142/9677DOI: 10.1142/9677
2015
Formulation of Solid Drug Nanoparticles for the Improved Oral Bioavailability of Antiretroviral Drugs (Poster)
Savage, A. C., Tatham, L. M., Owen, A., & Rannard, S. P. (2015). Formulation of Solid Drug Nanoparticles for the Improved Oral Bioavailability of Antiretroviral Drugs. Poster session presented at the meeting of British Society of Nanomedicine Young Researchers Meeting. University of Liverpool.
Flow cytometric analysis of the physical and protein-binding characteristics of solid drug nanoparticle suspensions (Journal article)
Liptrott, N. J., Giardiello, M., Hunter, J. W., Tatham, L., Tidbury, L. R., Siccardi, M., . . . Owen, A. (2015). Flow cytometric analysis of the physical and protein-binding characteristics of solid drug nanoparticle suspensions. NANOMEDICINE, 10(9), 1407-1421. doi:10.2217/NNM.14.77DOI: 10.2217/NNM.14.77
Nanoformulation strategies for the enhanced oral bioavailability of antiretroviral therapeutics (Journal article)
Tatham, L. M., Rannard, S. P., & Owen, A. (2015). Nanoformulation strategies for the enhanced oral bioavailability of antiretroviral therapeutics. THERAPEUTIC DELIVERY, 6(4), 469-490. doi:10.4155/TDE.15.4DOI: 10.4155/TDE.15.4
Hyperbranched polydendrons: a new nanomaterials platform with tuneable permeation through model gut epithelium (Journal article)
Hatton, F. L., Tatham, L. M., Tidbury, L. R., Chambon, P., He, T., Owen, A., & Rannard, S. P. (2015). Hyperbranched polydendrons: a new nanomaterials platform with tuneable permeation through model gut epithelium. CHEMICAL SCIENCE, 6(1), 326-334. doi:10.1039/c4sc02889aDOI: 10.1039/c4sc02889a
pH-Responsive hyperbranched-polydendrons for drug delivery applications (Conference Paper)
Rogers, H., Tatham, L., Chambon, P., Owen, A., & Rannard, S. (2015). pH-Responsive hyperbranched-polydendrons for drug delivery applications. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 250. Retrieved from https://www.webofscience.com/
2014
Flow cytometric analysis of the physical and protein-binding characteristics of solid drug nanoparticle suspensions (Journal article)
Liptrott, N., Giardiello, M., Hunter, J. W., Tatham, L., Tidbury, L. R., Siccardi, M., . . . Owen, A. (2014). Flow cytometric analysis of the physical and protein-binding characteristics of solid drug nanoparticle suspensions. Nanomedicine (London).
Highlights of research at the University of Liverpool and activity of the British Society for Nanomedicine (Poster)
Curley, P., Liptrott, N., Tatham, L., Siccardi, M., & Owen, A. (2014). Highlights of research at the University of Liverpool and activity of the British Society for Nanomedicine. Poster session presented at the meeting of 7th CLINAM Conference and Exhibition. Basel, Switzerland.
2013
High-throughput nanoprecipitation of the organic antimicrobial triclosan and enhancement of activity against <i>Escherichia coli</i> (Journal article)
McDonald, T. O., Tatham, L. M., Southworth, F. Y., Giardiello, M., Martin, P., Liptrott, N. J., . . . Rannard, S. P. (2013). High-throughput nanoprecipitation of the organic antimicrobial triclosan and enhancement of activity against <i>Escherichia coli</i>. JOURNAL OF MATERIALS CHEMISTRY B, 1(35), 4455-4465. doi:10.1039/c3tb20543fDOI: 10.1039/c3tb20543f
High-throughput nanoprecipitation of the organic antimicrobial triclosan and enhancement of activity against Escherichia coli (Journal article)
McDonald, T. O., Tatham, L. M., Southworth, F. Y., Giardiello, M., Martin, P., Liptrott, N. J., . . . Rannard, S. P. (2013). High-throughput nanoprecipitation of the organic antimicrobial triclosan and enhancement of activity against Escherichia coli. Journal of Materials Chemistry B, 1(35), 4455. doi:10.1039/c3tb20543fDOI: 10.1039/c3tb20543f
