Photo of Prof Rick Cosstick

Prof Rick Cosstick BSc, PhD

Professor and Dean of the School of Physical Sciences Chemistry

    Research

    Research Interests

    Research Highlights
    DNA (deoxyribonucleic acid) is the permanent repository of genetic information and the acquired understanding of the structure and function of DNA and the related RNA (ribonucleic acid), represent one of the greatest ever triumphs for chemistry and biology. It is not surprising that most of the licensed antiviral drugs (e.g. Zovirax and AZT) and many anticancer drugs are nucleoside analogues which are able to interfere with nucleic acid biosynthesis in a selective manner. Additionally, much of the recent information on the structure/function relationship of nucleic acids has come from using DNA/RNA probes that contain a subtle chemical modification. Present work within the group is concerned with studies on the synthesis of novel nucleic acids analogues as both potential therapeutic agents and as probes for understanding the precise mechanism by which nucleic acids fulfill their biological functions.

    Research Group Membership

    Research Grants

    Next generation DNA synthesis

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    January 2015 - April 2016

    Oligonucleotides Containing Phosphorothiolate Linkages: Synthesis and Applications.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    May 2003 - August 2006

    Acquisition of single crystal diffractometer with CCD detector.

    ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL (EPSRC)

    October 2000 - October 2003

    2'-C-Functionalised olignucleotides: ribozymes antisense and directed evolution.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    January 1998 - September 2002

    Increasing the Potency of RNA Interference Using RNA Mimics

    ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL (EPSRC)

    October 2007 - April 2010

    Investigating nitration-damaged DNA using a mimic of 8-nitro-2'-deoxyguanosine

    ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL (EPSRC)

    January 2010 - August 2013

    Research Collaborations

    Prof Aiden Doherty

    External: The University of Sussex

    Search for DNA repair proteins that correct the 8-nitroguanine lesion in DNA

    Prof Steven Bell

    External: Queens University Belfast

    Detection of DNA lesions by SERRS