2019
Kershaw, N. M., Byrne, D. P., Parsons, H., Berry, N. G., Fernig, D. G., Eyers, P. A., & Cosstick, R. (2019). Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors. RSC ADVANCES, 9(55), 32165-32173. doi:10.1039/c9ra07567dDOI: 10.1039/c9ra07567d
2018
Alexander, K. J., McConville, M., Williams, K. R., Luzyanin, K. V., O'Neil, I. A., & Cosstick, R. (2018). Chemistry of the 8‐Nitroguanine DNA Lesion: Reactivity, Labelling and Repair. Chemistry: A European Journal, 24(12), 3013-3020. doi:10.1002/chem.201705541DOI: 10.1002/chem.201705541
2017
Dick, S., Bell, S. E. J., Alexander, K. J., O'Neil, I. A., & Cosstick, R. (2017). SERS and SERRS Detection of the DNA Lesion 8‐Nitroguanine: A Self‐Labeling Modification. Chemistry (Weinheim an der Bergstrasse, Germany), 23(44), 10663-10669. doi:10.1002/chem.201701791DOI: 10.1002/chem.201701791
2016
Tautomerism in 8-Nitroguanosine Studied by NMR and Theoretical Calculations (Journal article)
Barbosa, T. M., Rittner, R., Alexander, K., Cosstick, R., & Abraham, R. J. (2016). Tautomerism in 8-Nitroguanosine Studied by NMR and Theoretical Calculations. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 35(2), 53-63. doi:10.1080/15257770.2015.1114127DOI: 10.1080/15257770.2015.1114127
2015
Nicked-site substrates for a serine recombinase reveal enzyme–DNA communications and an essential tethering role of covalent enzyme–DNA linkages (Journal article)
Olorunniji, F. J., McPherson, A. L., Pavlou, H. J., McIlwraith, M. J., Brazier, J. A., Cosstick, R., & Stark, W. M. (2015). Nicked-site substrates for a serine recombinase reveal enzyme–DNA communications and an essential tethering role of covalent enzyme–DNA linkages. Nucleic Acids Research, 43(12), 6134-6143. doi:10.1093/nar/gkv521DOI: 10.1093/nar/gkv521
Stabilization of a Bimolecular Triplex by 3′-S-Phosphorothiolate Modifications: An NMR and UV Thermal Melting Investigation (Journal article)
Evans, K., Bhamra, I., Wheelhouse, R. T., Arnold, J. R. P., Cosstick, R., & Fisher, J. (2015). Stabilization of a Bimolecular Triplex by 3′-S-Phosphorothiolate Modifications: An NMR and UV Thermal Melting Investigation. Chemistry - A European Journal, 21(19), 7278-7284. doi:10.1002/chem.201500369DOI: 10.1002/chem.201500369
Probing the Run-On Oligomer of Activated SgrAI Bound to DNA (Journal article)
Shah, S., Sanchez, J., Stewart, A., Piperakis, M. M., Cosstick, R., Nichols, C., . . . Horton, N. C. (2015). Probing the Run-On Oligomer of Activated SgrAI Bound to DNA. PLOS ONE, 10(4). doi:10.1371/journal.pone.0124783DOI: 10.1371/journal.pone.0124783
2013
Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation (Journal article)
La Pensee, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A. E., . . . O'Neill, P. M. (2013). Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation. CHEMMEDCHEM, 8(5), 709-718. doi:10.1002/cmdc.201200536DOI: 10.1002/cmdc.201200536
Thermal stabilisation of RNA·RNA duplexes and G-quadruplexes by phosphorothiolate linkages. (Journal article)
Piperakis, M. M., Gaynor, J. W., Fisher, J., & Cosstick, R. (2013). Thermal stabilisation of RNA·RNA duplexes and G-quadruplexes by phosphorothiolate linkages.. Organic & biomolecular chemistry, 11(6), 966-974. doi:10.1039/c2ob26940fDOI: 10.1039/c2ob26940f
2012
Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine † (Journal article)
Bhamra, I., Compagnone-Post, P., O’Neil, I. A., Iwanejko, L. A., Bates, A. D., & Cosstick, R. (2012). Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine †. Nucleic Acids Research, 40(21), 11126-11138. doi:10.1093/nar/gks799DOI: 10.1093/nar/gks799
Bhamra, I., Compagnone-Post, P., O'Neil, I. A., Iwanejko, L. A., Bates, A. D., & Cosstick, R. (2012). Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine.. Nucleic acids research, 40(21), 11126-11138. doi:10.1093/nar/gks799DOI: 10.1093/nar/gks799
2011
Dinucleotides Containing 3′-<i>S</i>-Phosphorothiolate Linkages (Journal article)
Gaynor, J. W., & Cosstick, R. (2011). Dinucleotides Containing 3′-<i>S</i>-Phosphorothiolate Linkages. THERAPEUTIC OLIGONUCLEOTIDES: METHODS AND PROTOCOLS, 764, 17-30. doi:10.1007/978-1-61779-188-8_2DOI: 10.1007/978-1-61779-188-8_2
2010
RNA interference: a chemist's perspective (Journal article)
Gaynor, J. W., Campbell, B. J., & Cosstick, R. (2010). RNA interference: a chemist's perspective. CHEMICAL SOCIETY REVIEWS, 39(11), 4169-4184. doi:10.1039/b920362cDOI: 10.1039/b920362c
A novel mechanism for the scission of double-stranded DNA: BfiI cuts both 3'-5' and 5'-3' strands by rotating a single active site (Journal article)
Sasnauskas, G., Zakrys, L., Zaremba, M., Cosstick, R., Gaynor, J. W., Halford, S. E., & Siksnys, V. (2010). A novel mechanism for the scission of double-stranded DNA: BfiI cuts both 3'-5' and 5'-3' strands by rotating a single active site. NUCLEIC ACIDS RESEARCH, 38(7), 2399-2410. doi:10.1093/nar/gkp1194DOI: 10.1093/nar/gkp1194
Reverse-direction (5′→3′) synthesis of oligonucleotides containing a 3′-<i>S</i>-phosphorothiolate linkage and 3′-terminal 3′-thionucleosides (Journal article)
Gaynor, J. W., Piperakis, M. M., Fisher, J., & Cosstick, R. (2010). Reverse-direction (5′→3′) synthesis of oligonucleotides containing a 3′-<i>S</i>-phosphorothiolate linkage and 3′-terminal 3′-thionucleosides. ORGANIC & BIOMOLECULAR CHEMISTRY, 8(6), 1463-1470. doi:10.1039/b923545kDOI: 10.1039/b923545k
2009
Antitumour and antimalarial activity of artemisinin-acridine hybrids (Journal article)
Jones, M., Mercer, A. E., Stocks, P. A., La Pensee, L. J. I., Cosstick, R., Park, B. K., . . . O'Neill, P. M. (2009). Antitumour and antimalarial activity of artemisinin-acridine hybrids. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(7), 2033-2037. doi:10.1016/j.bmcl.2009.02.028DOI: 10.1016/j.bmcl.2009.02.028
Antitumour and antimalarial activity of artemisinin–acridine hybrids (Journal article)
Jones, M., Mercer, A. E., Stocks, P. A., La Pensée, L. J. I., Cosstick, R., Park, B. K., . . . O’Neill, P. M. (2009). Antitumour and antimalarial activity of artemisinin–acridine hybrids. Bioorganic & Medicinal Chemistry Letters, 19(7), 2033-2037. doi:10.1016/j.bmcl.2009.02.028DOI: 10.1016/j.bmcl.2009.02.028
Nitrobenzyl Phototrigger for Fast Protein Folding Processes (Journal article)
Whynes, R. P., Barriuso, M. G., Cosstick, R., & Volk, M. (2009). Nitrobenzyl Phototrigger for Fast Protein Folding Processes. Biophysical Journal, 96(3), 324a. doi:10.1016/j.bpj.2008.12.1629DOI: 10.1016/j.bpj.2008.12.1629
Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against <i>P-falciparum</i> malaria parasites and HL-60 cancer cells (Journal article)
Chadwick, J., Mercer, A. E., Park, B. K., Cosstick, R., & O'Neill, P. M. (2009). Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against <i>P-falciparum</i> malaria parasites and HL-60 cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY, 17(3), 1325-1338. doi:10.1016/j.bmc.2008.12.017DOI: 10.1016/j.bmc.2008.12.017
2008
Foldamers derived from nucleoside beta-amino acids: a new twist on the DNA helix. (Journal article)
Cosstick, R., Threlfall, R., & Fisher, J. (2008). Foldamers derived from nucleoside beta-amino acids: a new twist on the DNA helix.. Nucleic acids symposium series (2004), (52), 313-314. doi:10.1093/nass/nrn158DOI: 10.1093/nass/nrn158
Incorporation of 3'-S-phosphorothiolates into RNA: potential applications in RNAi. (Journal article)
Gaynor, J., Fisher, J., Campbell, B., & Cosstick, R. (2008). Incorporation of 3'-S-phosphorothiolates into RNA: potential applications in RNAi.. Nucleic acids symposium series (2004), (52), 319-320. doi:10.1093/nass/nrn161DOI: 10.1093/nass/nrn161
Towards fluorous-phase synthesis of nucleoside beta-peptides. (Journal article)
Threlfall, R., Cosstick, R., & Wada, T. (2008). Towards fluorous-phase synthesis of nucleoside beta-peptides.. Nucleic acids symposium series (2004), (52), 337-338. doi:10.1093/nass/nrn170DOI: 10.1093/nass/nrn170
The effect of 2'-fluorine substitutions on DNA i-motif conformation and stability. (Journal article)
Fenna, C. P., Wilkinson, V. J., Arnold, J. R. P., Cosstick, R., & Fisher, J. (2008). The effect of 2'-fluorine substitutions on DNA i-motif conformation and stability.. Chemical communications (Cambridge, England), (30), 3567-3569. doi:10.1039/b804833aDOI: 10.1039/b804833a
Synthesis, properties and application of nucleic acids containing phosphorothiolate linkages (Journal article)
Gaynor, J. W., & Cosstick, R. (2008). Synthesis, properties and application of nucleic acids containing phosphorothiolate linkages. Current Organic Chemistry, 12(4), 291-308.
Synthesis, properties and application of nucleic acids containing phosphorothiolate linkages (Journal article)
Gaynor, J. W., & Cosstick, R. (2008). Synthesis, properties and application of nucleic acids containing phosphorothiolate linkages. CURRENT ORGANIC CHEMISTRY, 12(4), 291-308. Retrieved from https://www.webofscience.com/
Peptides derived from nucleoside beta-amino acids form an unusual 8-helix. (Journal article)
Threlfall, R., Davies, A., Howarth, N. M., Fisher, J., & Cosstick, R. (2008). Peptides derived from nucleoside beta-amino acids form an unusual 8-helix.. Chemical communications (Cambridge, England), (5), 585-587. doi:10.1039/b714350hDOI: 10.1039/b714350h
Incorporation of 3′-S-phosphorothiolates into RNA; potential applications in RNAi (Journal article)
Gaynor, J. W., Fisher, J., Campbell, B., & Cosstick, R. (2008). Incorporation of 3′-S-phosphorothiolates into RNA; potential applications in RNAi. Nucleic Acids Symposium Series, 52(1), 319-320.
2007
Foldamers derived from nucleoside beta-amino acids: PNA Or DNA? Can we have both in one place? (Journal article)
Threlfall, R., Davies, A., Howarth, N., & Cosstick, R. (2007). Foldamers derived from nucleoside beta-amino acids: PNA Or DNA? Can we have both in one place?. Nucleosides, nucleotides & nucleic acids, 26(6-7), 611-614. doi:10.1080/15257770701490399DOI: 10.1080/15257770701490399
Stabilization of multi-stranded nucleic acid structures using 3'-S-phosphorothiolate linkages. (Journal article)
Cosstick, R., Buckingham, J., Brazier, J., & Fisher, J. (2007). Stabilization of multi-stranded nucleic acid structures using 3'-S-phosphorothiolate linkages.. Nucleosides, nucleotides & nucleic acids, 26(6-7), 555-558. doi:10.1080/15257770701490001DOI: 10.1080/15257770701490001
Synthesis of 3′-<i>S</i>-phosphorothiolate oligonucleotides for their potential use in RNA interference (Journal article)
Gaynor, J. W., Brazier, J., & Cosstick, R. (2007). Synthesis of 3′-<i>S</i>-phosphorothiolate oligonucleotides for their potential use in RNA interference. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 26(6-7), 709-712. doi:10.1080/15257770701490753DOI: 10.1080/15257770701490753
Duplex stability of DNA.DNA and DNA.RNA duplexes containing 3'-S-phosphorothiolate linkages. (Journal article)
Bentley, J., Brazier, J. A., Fisher, J., & Cosstick, R. (2007). Duplex stability of DNA.DNA and DNA.RNA duplexes containing 3'-S-phosphorothiolate linkages.. Organic & biomolecular chemistry, 5(22), 3698-3702. doi:10.1039/b713292aDOI: 10.1039/b713292a
Enzymatic disassembly of DNA-gold nanostructures (Journal article)
Kanaras, A. G., Wang, Z., Brust, M., Cosstick, R., & Bates, A. D. (2007). Enzymatic disassembly of DNA-gold nanostructures. SMALL, 3(4), 590-594. doi:10.1002/smll.200600494DOI: 10.1002/smll.200600494
Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity. (Journal article)
Beckman, J., Kincaid, K., Hocek, M., Spratt, T., Engels, J., Cosstick, R., & Kuchta, R. D. (2007). Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity.. Biochemistry, 46(2), 448-460. doi:10.1021/bi061243sDOI: 10.1021/bi061243s
Incorporation of a S-glycosidic linkage into a glyconucleoside changes the conformational preference of both furanose sugars. (Journal article)
Buckingham, J., Brazier, J. A., Fisher, J., & Cosstick, R. (2007). Incorporation of a S-glycosidic linkage into a glyconucleoside changes the conformational preference of both furanose sugars.. Carbohydrate research, 342(1), 16-22. doi:10.1016/j.carres.2006.11.007DOI: 10.1016/j.carres.2006.11.007
Site-specific ligation of DNA-modified gold nanoparticles activated by the restriction enzyme <i>Sty</i>I (Journal article)
Kanaras, A. G., Wang, Z., Hussain, I., Brust, M., Cosstick, R., & Bates, A. D. (2007). Site-specific ligation of DNA-modified gold nanoparticles activated by the restriction enzyme <i>Sty</i>I. SMALL, 3(1), 67-70. doi:10.1002/smll.200600464DOI: 10.1002/smll.200600464
NMR studies of the conformational effect of single and double 3′-<i>S</i>-phosphorothiolate substitutions within deoxythymidine trinucleotides (Journal article)
Jayakumar, H. K., Buckingham, J. L., Brazier, J. A., Berry, N. G., Cosstick, R., & Fisher, J. (2007). NMR studies of the conformational effect of single and double 3′-<i>S</i>-phosphorothiolate substitutions within deoxythymidine trinucleotides. MAGNETIC RESONANCE IN CHEMISTRY, 45(4), 340-345. doi:10.1002/mrc.1977DOI: 10.1002/mrc.1977
Syntheses of 2′-C-amidoalkyl and 2′-C-cyanoalkyl containing oligodeoxyribonucleotides and assessment of their hybridisation affinity for complementary DNA and RNA (Journal article)
Brennan, L., Cosstick, R., O'Neil, I. A., & Van Aerschot, A. (2007). Syntheses of 2′-C-amidoalkyl and 2′-C-cyanoalkyl containing oligodeoxyribonucleotides and assessment of their hybridisation affinity for complementary DNA and RNA. Tetrahedron, 63(3), 577-585. doi:10.1016/j.tet.2006.11.024DOI: 10.1016/j.tet.2006.11.024
Synthesis of the 3′-thio-nucleosides and subsequent automated synthesis of oligodeoxynucleotides containing a 3′-<i>S</i>-phosphorothiolate linkage (Journal article)
Gaynor, J. W., Bentley, J., & Cosstick, R. (2007). Synthesis of the 3′-thio-nucleosides and subsequent automated synthesis of oligodeoxynucleotides containing a 3′-<i>S</i>-phosphorothiolate linkage. NATURE PROTOCOLS, 2(12), 3122-3135. doi:10.1038/nprot.2007.451DOI: 10.1038/nprot.2007.451
The Biochemical and Physiological Genesis of Alliin in Garlic (Journal article)
Jones, M. G., Colin, H. A., Tregova, A., Trueman, L., Brown, L., Cosstick, R., . . . Thomas, B. (2007). The Biochemical and Physiological Genesis of Alliin in Garlic. Medicinal and Aromatic Plant Science and Biotechnology, 1(1).
2006
Gold nanoparticle wires made using RNA-based self-assembly (Journal article)
Cumming, D. R. S., Bates, A. D., Callen, B. P., Cooper, J. M., Cosstick, R., Geary, C., . . . Xu, C. (2006). Gold nanoparticle wires made using RNA-based self-assembly. Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures Processing, Measurement, and Phenomena, 24(6), 3196-3199. doi:10.1116/1.2363404DOI: 10.1116/1.2363404
A combined top-down bottom-up approach for introducing nanoparticle networks into nanoelectrode gaps (Journal article)
Xu, C., van Zalinge, H., Pearson, J. L., Glidle, A., Cooper, J. M., Cumming, D. R. S., . . . Nichols, R. J. (2006). A combined top-down bottom-up approach for introducing nanoparticle networks into nanoelectrode gaps. NANOTECHNOLOGY, 17(14), 3333-3339. doi:10.1088/0957-4484/17/14/001DOI: 10.1088/0957-4484/17/14/001
Effect of low storage temperature on some of the flavour precursors in garlic (Allium sativum). (Journal article)
Hughes, J., Collin, H. A., Tregova, A., Tomsett, A. B., Cosstick, R., & Jones, M. G. (2006). Effect of low storage temperature on some of the flavour precursors in garlic (Allium sativum).. Plant foods for human nutrition (Dordrecht, Netherlands), 61(2), 81-85. doi:10.1007/s11130-006-0018-4DOI: 10.1007/s11130-006-0018-4
Construction and characterization of a gold nanoparticle wire assembled using Mg2+-dependent RNA-RNA interactions. (Journal article)
Bates, A. D., Callen, B. P., Cooper, J. M., Cosstick, R., Geary, C., Glidle, A., . . . Cumming, D. R. S. (2006). Construction and characterization of a gold nanoparticle wire assembled using Mg2+-dependent RNA-RNA interactions.. Nano letters, 6(3), 445-448. doi:10.1021/nl052316gDOI: 10.1021/nl052316g
2005
Stabilization of the DNA I-motif structure by incorporation of 3'-S-phosphorothiolate linkages. (Journal article)
Brazier, J. A., Fisher, J., & Cosstick, R. (2005). Stabilization of the DNA I-motif structure by incorporation of 3'-S-phosphorothiolate linkages.. Angewandte Chemie (International ed. in English), 45(1), 114-117. doi:10.1002/anie.200503110DOI: 10.1002/anie.200503110
Mechanism of the Escherichia coli DNA T:G-mismatch endonuclease (Vsr protein) probed with thiophosphate-containing oligodeoxynucleotides. (Journal article)
Elliott, S. L., Brazier, J., Cosstick, R., & Connolly, B. A. (2005). Mechanism of the Escherichia coli DNA T:G-mismatch endonuclease (Vsr protein) probed with thiophosphate-containing oligodeoxynucleotides.. Journal of molecular biology, 353(3), 692-703. doi:10.1016/j.jmb.2005.08.048DOI: 10.1016/j.jmb.2005.08.048
Control of DNA conformation using 3'-S-phosphorothiolate-modified linkages. (Journal article)
Buckingham, J., Sabbagh, G., Brazier, J., Fisher, J., & Cosstick, R. (2005). Control of DNA conformation using 3'-S-phosphorothiolate-modified linkages.. Nucleosides, nucleotides & nucleic acids, 24(5-7), 491-495. doi:10.1081/ncn-200061776DOI: 10.1081/ncn-200061776
Studies on the attachment of DNA to silica-coated nanoparticles through a Diels-Alder reaction (Journal article)
Proupin-Perez, M., Cosstick, R., Liz-Marzan, L. M., Salgueiriño-Maceira, V., & Brust, M. (2005). Studies on the attachment of DNA to silica-coated nanoparticles through a Diels-Alder reaction. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 24(5-7), 1075-1079. doi:10.1081/NCN-200059170DOI: 10.1081/NCN-200059170
SULFUR BIOCHEMISTRY OF GARLIC: THE BIOSYNTHESIS OF FLAVOR PRECURSORS (Conference Paper)
Collin, H. A., Hughes, J., Tregova, A., Milne, J. G. C., van der Werff, G., Wilkinson, M., . . . Thomas, B. (2005). SULFUR BIOCHEMISTRY OF GARLIC: THE BIOSYNTHESIS OF FLAVOR PRECURSORS. In Acta Horticulturae (pp. 165-172). International Society for Horticultural Science (ISHS). doi:10.17660/actahortic.2005.688.20DOI: 10.17660/actahortic.2005.688.20
Synthesis of the flavour precursor, alliin, in garlic tissue cultures. (Journal article)
Hughes, J., Tregova, A., Tomsett, A. B., Jones, M. G., Cosstick, R., & Collin, H. A. (2005). Synthesis of the flavour precursor, alliin, in garlic tissue cultures.. Phytochemistry, 66(2), 187-194. doi:10.1016/j.phytochem.2004.11.009DOI: 10.1016/j.phytochem.2004.11.009
2004
Synthesis and transcription studies on 5'-triphosphates derived from 2'-C-branched-uridines: 2'-homouridine-5'-triphosphate is a substrate for T7 RNA polymerase. (Journal article)
Pavey, J. B. J., Lawrence, A. J., O'Neil, I. A., Vortler, S., & Cosstick, R. (2004). Synthesis and transcription studies on 5'-triphosphates derived from 2'-C-branched-uridines: 2'-homouridine-5'-triphosphate is a substrate for T7 RNA polymerase.. Organic & biomolecular chemistry, 2(6), 869-875. doi:10.1039/b314348aDOI: 10.1039/b314348a
Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10β-(2-hydroxyethyl)deoxoartemisinin (Journal article)
Jeyadevan, J. P., Bray, P. G., Chadwick, J., Mercer, A. E., Byrne, A., Ward, S. A., . . . O'Neill, P. M. (2004). Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10β-(2-hydroxyethyl)deoxoartemisinin. JOURNAL OF MEDICINAL CHEMISTRY, 47(5), 1290-1298. doi:10.1021/jm030974cDOI: 10.1021/jm030974c
Synthesis of phosphorothioamidites derived from 3'-thio-3'-deoxythymidine and 3'-thio-2',3'-dideoxycytidine and the automated synthesis of oligodeoxynucleotides containing a 3'-S-phosphorothiolate linkage. (Journal article)
Sabbagh, G., Fettes, K. J., Gosain, R., O'Neil, I. A., & Cosstick, R. (2004). Synthesis of phosphorothioamidites derived from 3'-thio-3'-deoxythymidine and 3'-thio-2',3'-dideoxycytidine and the automated synthesis of oligodeoxynucleotides containing a 3'-S-phosphorothiolate linkage.. Nucleic acids research, 32(2), 495-501. doi:10.1093/nar/gkh189DOI: 10.1093/nar/gkh189
NMR and UV studies of 3'-S-phosphorothiolate modified DNA in a DNA : RNA hybrid dodecamer duplex; implications for antisense drug design. (Journal article)
Beevers, A. P. G., Fettes, K. J., Sabbagh, G., Murad, F. K., Arnold, J. R. P., Cosstick, R., & Fisher, J. (2004). NMR and UV studies of 3'-S-phosphorothiolate modified DNA in a DNA : RNA hybrid dodecamer duplex; implications for antisense drug design.. Organic & biomolecular chemistry, 2(1), 114-119. doi:10.1039/b311923hDOI: 10.1039/b311923h
Enzymatic DNA processing on gold nanoparticles (Journal article)
Wang, Z. X., Kanaras, A. G., Bates, A. D., Cosstick, R., & Brust, M. (2004). Enzymatic DNA processing on gold nanoparticles. JOURNAL OF MATERIALS CHEMISTRY, 14(4), 578-580. doi:10.1039/b314328gDOI: 10.1039/b314328g
2003
Towards multistep nanostructure synthesis: Programmed enzymatic self-assembly of DNA/gold systems (Journal article)
Kanaras, A. G., Wang, Z. X., Bates, A. D., Cosstick, R., & Brust, M. (2003). Towards multistep nanostructure synthesis: Programmed enzymatic self-assembly of DNA/gold systems. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 42(2), 191-+. doi:10.1002/anie.200390075DOI: 10.1002/anie.200390075
Studies on 2'-alpha-C-carboxyalkyl nucleosides and their application to a stereocontrolled nucleobase exchange process. (Journal article)
Fehring, V., Knights, S., Chan, M. -Y., O'Neil, I. A., & Cosstick, R. (2003). Studies on 2'-alpha-C-carboxyalkyl nucleosides and their application to a stereocontrolled nucleobase exchange process.. Organic & biomolecular chemistry, 1(1), 123-128. doi:10.1039/b208786nDOI: 10.1039/b208786n
2002
Probing the effect of a 3'-S-phosphorothiolate link on the conformation of a DNA:RNA hybrid; implications for antisense drug design. (Journal article)
Beevers, A. P. G., Fettes, K. J., O'Neil, I. A., Roberts, S. M., Arnold, J. R. P., Cosstick, R., & Fisher, J. (2002). Probing the effect of a 3'-S-phosphorothiolate link on the conformation of a DNA:RNA hybrid; implications for antisense drug design.. Chemical communications (Cambridge, England), (14), 1458-1459. doi:10.1039/b203582kDOI: 10.1039/b203582k
2001
Novel macrocycles derived from nucleosides. (Journal article)
Calcerrada-Muñoz, N., O'Neil, I., & Cosstick, R. (2001). Novel macrocycles derived from nucleosides.. Nucleosides, nucleotides & nucleic acids, 20(4-7), 1347-1350. doi:10.1081/ncn-100002552DOI: 10.1081/ncn-100002552
Solid-phase synthesis of oligodeoxynucleotides containing 3'-S-phosphorothiolate linkages. (Journal article)
Fettes, K. J., O'Neil, I., Roberts, S. M., & Cosstick, R. (2001). Solid-phase synthesis of oligodeoxynucleotides containing 3'-S-phosphorothiolate linkages.. Nucleosides, nucleotides & nucleic acids, 20(4-7), 1351-1354. doi:10.1081/ncn-100002553DOI: 10.1081/ncn-100002553
The synthesis of, and studies on, 2'-C-modified nucleotides. (Journal article)
Brennan, L., Fettes, K. J., O'Neil, I. A., & Cosstick, R. (2001). The synthesis of, and studies on, 2'-C-modified nucleotides.. Nucleosides, nucleotides & nucleic acids, 20(4-7), 1339-1341. doi:10.1081/ncn-100002550DOI: 10.1081/ncn-100002550
2000
A novel stereo-controlled nucleobase exchange process for the synthesis of 2′-C-branched nucleosides (Journal article)
Fehring, V., Chan, M. Y., O’Neil, I. A., & Cosstick, R. (2000). A novel stereo-controlled nucleobase exchange process for the synthesis of 2′-C-branched nucleosides. Journal of the Chemical Society, Perkin Transactions 1, (19), 3185-3187. doi:10.1039/b007099hDOI: 10.1039/b007099h
Hydrolytic Reactions of the cis-methyl ester of 3 '-deoxy-3 '-thiothymidine 3 ',5 '-cyclic(phosphorothiolate) (Journal article)
Elzagheid, M. I., Mattila, K., Oivanen, M., Jones, B. C. N. M., Cosstick, R., & Lonnberg, H. (2000). Hydrolytic Reactions of the cis-methyl ester of 3 '-deoxy-3 '-thiothymidine 3 ',5 '-cyclic(phosphorothiolate). EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (10), 1987-1991.
1999
Hydrolytic Reactions of 3′-Deoxy-3′-thioinosylyl-(3′→ >5′)-uridine; An RNA Dinucleotide Containing a 3′-<i>S</i>-Phosphorothiolate Linkage (Journal article)
Elzagheid, M. I., Oivanen, M., Klika, K. D., Jones, B. C. N. M., Cosstick, R., & Lönnberg, H. (1999). Hydrolytic Reactions of 3′-Deoxy-3′-thioinosylyl-(3′→ >5′)-uridine; An RNA Dinucleotide Containing a 3′-<i>S</i>-Phosphorothiolate Linkage. Nucleosides and Nucleotides, 18(9), 2093-2108. doi:10.1080/07328319908044866DOI: 10.1080/07328319908044866
Hydrolytic Reactions of an RNA Dinucleotide Containing a 3′-<i>S</i>-Phosphorothiolate Linkage (Journal article)
Elzagheid, M., Oivanen, M., Colin, B., Jones, N. M., Cosstick, R., & Lönnberg, H. (1999). Hydrolytic Reactions of an RNA Dinucleotide Containing a 3′-<i>S</i>-Phosphorothiolate Linkage. Nucleosides and Nucleotides, 18(6-7), 1265-1266. doi:10.1080/07328319908044687DOI: 10.1080/07328319908044687
Conformational analysis of 3'-S-PO3-linked ribo- and deoxyribodinucleoside monophosphates (Journal article)
Beevers, A. P. G., Witch, E. M., Jones, B. C. N. M., Cosstick, R., Arnold, J. R. P., & Fisher, J. (1999). Conformational analysis of 3'-S-PO3-linked ribo- and deoxyribodinucleoside monophosphates. MAGNETIC RESONANCE IN CHEMISTRY, 37(11), 814-820.
Synthesis and duplex stability of oligodeoxyribonucleotides containing a 2′→5′-amide linkage (Journal article)
Chan, M. -Y., Fairhurst, R. A., Collingwood, S. P., Fisher, J., Arnold, J. R. P., Cosstick, R., & O’Neil, I. A. (1999). Synthesis and duplex stability of oligodeoxyribonucleotides containing a 2′→5′-amide linkage. Journal of the Chemical Society, Perkin Transactions 1, (3), 315-320. doi:10.1039/a808505fDOI: 10.1039/a808505f
1998
The synthesis of a novel 2′,3′-cyclic phosphate derived from 2′-homouridine (Journal article)
Pavey, J. B. J., Cosstick, R., & O'Neil, I. A. (1998). The synthesis of a novel 2′,3′-cyclic phosphate derived from 2′-homouridine. Tetrahedron Letters, 39(48), 8923-8924. doi:10.1016/s0040-4039(98)01952-2DOI: 10.1016/s0040-4039(98)01952-2
The synthesis of 2′-homouridine, its incorporation into a dinucleoside monophosphate and hydrolytic behaviour of the dimer (Journal article)
Pavey, J. B. J., Lawrence, A. J., Potter, A. J., Cosstick, R., & O'Neil, I. A. (1998). The synthesis of 2′-homouridine, its incorporation into a dinucleoside monophosphate and hydrolytic behaviour of the dimer. Tetrahedron Letters, 39(38), 6967-6970. doi:10.1016/s0040-4039(98)01478-6DOI: 10.1016/s0040-4039(98)01478-6
1997
A second catalytic metal ion in group I ribozyme. (Journal article)
Weinstein, L. B., Jones, B. C., Cosstick, R., & Cech, T. R. (1997). A second catalytic metal ion in group I ribozyme.. Nature, 388(6644), 805-808. doi:10.1038/42076DOI: 10.1038/42076
Dinucleoside Monophosphate Analogues Containing Disulfide Linkages (Journal article)
Witch, E. M., & Cosstick, R. (1997). Dinucleoside Monophosphate Analogues Containing Disulfide Linkages. Nucleosides and Nucleotides, 16(7-9), 1555-1558. doi:10.1080/07328319708006228DOI: 10.1080/07328319708006228
The RuvC protein dimer resolves Holliday junctions by a dual incision mechanism that involves base-specific contacts. (Journal article)
Shah, R., Cosstick, R., & West, S. C. (1997). The RuvC protein dimer resolves Holliday junctions by a dual incision mechanism that involves base-specific contacts.. The EMBO journal, 16(6), 1464-1472. doi:10.1093/emboj/16.6.1464DOI: 10.1093/emboj/16.6.1464
Synthesis, structure and reactions of uridine 2′-C,3′-O-γ-butyrolactone: versatile intermediate for the synthesis of 2′-C-branched nucleosides (Journal article)
Lawrence, A. J., Pavey, J. B. J., Chan, M. -Y., Fairhurst, R. A., Collingwood, S. P., Fisher, J., . . . O’Neil, I. A. (1997). Synthesis, structure and reactions of uridine 2′-C,3′-O-γ-butyrolactone: versatile intermediate for the synthesis of 2′-C-branched nucleosides. Journal of the Chemical Society, Perkin Transactions 1, (18), 2761-2768. doi:10.1039/a702088kDOI: 10.1039/a702088k
The synthesis of 2'-C-functionalised nucleosides for incorporation into catalytic RNA (Journal article)
Lawrence, A. J., Pavey, J. B. J., ONeil, I. A., & Cosstick, R. (1997). The synthesis of 2'-C-functionalised nucleosides for incorporation into catalytic RNA. Nucleosides and Nucleotides, 16(7-9), 497-1501.
1996
Synthesis and Properties of 2‘-Deoxy-2‘-α-<i>C</i>-branched Nucleosides and Nucleotides (Journal article)
Lawrence, A. J., Pavey, J. B. J., Cosstick, R., & O'Neil, I. A. (1996). Synthesis and Properties of 2‘-Deoxy-2‘-α-<i>C</i>-branched Nucleosides and Nucleotides. The Journal of Organic Chemistry, 61(26), 9213-9222. doi:10.1021/jo9614607DOI: 10.1021/jo9614607
Synthesis and characterization of an RNA dinucleotide containing a 3'-S-phosphorothiolate linkage (Journal article)
Weinstein, L. B., Earnshaw, D. J., Cosstick, R., & Cech, T. R. (1996). Synthesis and characterization of an RNA dinucleotide containing a 3'-S-phosphorothiolate linkage. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 118(43), 0341-10350.
Synthesis and structure of S-nucleosidyl S-aryl disulfides and their reaction with phosphites (Journal article)
Higson, A. P., Scott, G. K., Earnshaw, D. J., Baxter, A. D., Taylor, R. A., & Cosstick, R. (1996). Synthesis and structure of S-nucleosidyl S-aryl disulfides and their reaction with phosphites. Tetrahedron, 52(3), 1027-1034. doi:10.1016/0040-4020(95)00936-1DOI: 10.1016/0040-4020(95)00936-1
1995
The specific binding of Escherichia coli integration host factor involves both major and minor grooves of DNA. (Journal article)
Wang, S., Cosstick, R., Gardner, J. F., & Gumport, R. I. (1995). The specific binding of Escherichia coli integration host factor involves both major and minor grooves of DNA.. Biochemistry, 34(40), 13082-13090. doi:10.1021/bi00040a020DOI: 10.1021/bi00040a020
1993
Thermodynamic stability and drug-binding properties of oligodeoxyribonucleotide duplexes containing 3-deazaadenine:thymine base pairs. (Journal article)
Lever, C., Li, X., Cosstick, R., Ebel, S., & Brown, T. (1993). Thermodynamic stability and drug-binding properties of oligodeoxyribonucleotide duplexes containing 3-deazaadenine:thymine base pairs.. Nucleic acids research, 21(8), 1743-1746. doi:10.1093/nar/21.8.1743DOI: 10.1093/nar/21.8.1743
1992
Sequence- and strand-specific cleavage in oligodeoxyribonucleotides and DNA containing 3'-thiothymidine. (Journal article)
Vyle, J. S., Connolly, B. A., Kemp, D., & Cosstick, R. (1992). Sequence- and strand-specific cleavage in oligodeoxyribonucleotides and DNA containing 3'-thiothymidine.. Biochemistry, 31(11), 3012-3018. doi:10.1021/bi00126a024DOI: 10.1021/bi00126a024
1991
Properties of the diadenosine tetraphosphate nucleoside analogue, bis (N6-adenosyl)dodecane, and its possible use in the treatment of disorders of purine metabolism. (Journal article)
Chen, H., Cosstick, R., & McLennan, A. G. (1991). Properties of the diadenosine tetraphosphate nucleoside analogue, bis (N6-adenosyl)dodecane, and its possible use in the treatment of disorders of purine metabolism.. Biochemical Society transactions, 19(2), 123S. doi:10.1042/bst019123sDOI: 10.1042/bst019123s
Synthesis of cross-linked nucleosides as potential inhibitors of thymidine kinase. (Journal article)
Cosstick, R., & Nayyar, S. Z. (1991). Synthesis of cross-linked nucleosides as potential inhibitors of thymidine kinase.. Nucleic acids symposium series, (24), 292.
Synthesis of oligonucleotides containing 3-deaza-2'-deoxyadenosine. Interaction of the oligonucleotides with the drug distamycin A. (Journal article)
Cosstick, R., & Lever, C. (1991). Synthesis of oligonucleotides containing 3-deaza-2'-deoxyadenosine. Interaction of the oligonucleotides with the drug distamycin A.. Nucleic acids symposium series, (24), 291.
1990
Incorporation of a complete set of deoxyadenosine and thymidine analogues suitable for the study of protein nucleic acid interactions into oligodeoxynucleotides. Application to the EcoRV restriction endonuclease and modification methylase. (Journal article)
Newman, P. C., Nwosu, V. U., Williams, D. M., Cosstick, R., Seela, F., & Connolly, B. A. (1990). Incorporation of a complete set of deoxyadenosine and thymidine analogues suitable for the study of protein nucleic acid interactions into oligodeoxynucleotides. Application to the EcoRV restriction endonuclease and modification methylase.. Biochemistry, 29(42), 9891-9901. doi:10.1021/bi00494a020DOI: 10.1021/bi00494a020
Interaction of the EcoRV restriction endonuclease with the deoxyadenosine and thymidine bases in its recognition hexamer d(GATATC). (Journal article)
Newman, P. C., Williams, D. M., Cosstick, R., Seela, F., & Connolly, B. A. (1990). Interaction of the EcoRV restriction endonuclease with the deoxyadenosine and thymidine bases in its recognition hexamer d(GATATC).. Biochemistry, 29(42), 9902-9910. doi:10.1021/bi00494a021DOI: 10.1021/bi00494a021
Molecular recognition in the minor groove of the DNA helix. Studies on the synthesis of oligonucleotides and polynucleotides containing 3-deaza-2'-deoxyadenosine. Interaction of the oligonucleotides with the restriction endonuclease EcoRV. (Journal article)
Cosstick, R., Li, X., Tuli, D. K., Williams, D. M., Connolly, B. A., & Newman, P. C. (1990). Molecular recognition in the minor groove of the DNA helix. Studies on the synthesis of oligonucleotides and polynucleotides containing 3-deaza-2'-deoxyadenosine. Interaction of the oligonucleotides with the restriction endonuclease EcoRV.. Nucleic acids research, 18(16), 4771-4778.
Synthesis and properties of dithymidine phosphate analogues containing 3'-thiothymidine. (Journal article)
Cosstick, R., & Vyle, J. S. (1990). Synthesis and properties of dithymidine phosphate analogues containing 3'-thiothymidine.. Nucleic acids research, 18(4), 829-835. doi:10.1093/nar/18.4.829DOI: 10.1093/nar/18.4.829
Aplastic anaemia associated with organochlorine pesticide: case reports and review of evidence. (Journal article)
Rugman, F. P., & Cosstick, R. (1990). Aplastic anaemia associated with organochlorine pesticide: case reports and review of evidence.. Journal of clinical pathology, 43(2), 98-101. doi:10.1136/jcp.43.2.98DOI: 10.1136/jcp.43.2.98
Synthesis of bridged dinucleosides (Journal article)
Agathocleous, D. C., Bulman Page, P. C., Cosstick, R., Galpin, I. J., McLennan, A. G., & Prescott, M. (1990). Synthesis of bridged dinucleosides. Tetrahedron, 46(6), 2047-2058. doi:10.1016/s0040-4020(01)89771-4DOI: 10.1016/s0040-4020(01)89771-4
1989
The Inhibition of Adenosine Kinase by α,ω-Di (Adenosin -<u>N</u><sup>6</sup>- YL) Alkanes<sup>1</sup> (Journal article)
Prescott, M., McLennan, A. G., Agathocleous, D. C., Bulman Page, P. C., Cosstick, R., & Galpin, I. J. (1989). The Inhibition of Adenosine Kinase by α,ω-Di (Adenosin -<u>N</u><sup>6</sup>- YL) Alkanes<sup>1</sup>. Nucleosides and Nucleotides, 8(2), 297-303. doi:10.1080/07328318908054174DOI: 10.1080/07328318908054174
1988
Biological activity of (<i>N</i>6-N6)-bridged diadenosines (Journal article)
AGATHOCLEOUS, D. C., COSSTICK, R., GALPIN, I. J., McLENNAN, A. G., PAGE, P. C. B., & PRESCOTT, M. (1988). Biological activity of (<i>N</i>6-N6)-bridged diadenosines. Biochemical Society Transactions, 16(5), 756-757. doi:10.1042/bst0160756DOI: 10.1042/bst0160756
1987
An approach to the stereoselective synthesis of Sp-dinucleoside phosphorothioates using phosphotriester chemistry. (Journal article)
Cosstick, R., & Williams, D. M. (1987). An approach to the stereoselective synthesis of Sp-dinucleoside phosphorothioates using phosphotriester chemistry.. Nucleic acids research, 15(23), 9921-9932. doi:10.1093/nar/15.23.9921DOI: 10.1093/nar/15.23.9921
1986
Chiral phosphorothioate analogues of B-DNA. The crystal structure of Rp-d[Gp(S)CpGp(S)CpGp(S)C]. (Journal article)
Cruse, W. B., Salisbury, S. A., Brown, T., Cosstick, R., Eckstein, F., & Kennard, O. (1986). Chiral phosphorothioate analogues of B-DNA. The crystal structure of Rp-d[Gp(S)CpGp(S)CpGp(S)C].. Journal of molecular biology, 192(4), 891-905. doi:10.1016/0022-2836(86)90035-5DOI: 10.1016/0022-2836(86)90035-5
1985
The use of phosphorothioate-modified DNA in restriction enzyme reactions to prepare nicked DNA. (Journal article)
Taylor, J. W., Schmidt, W., Cosstick, R., Okruszek, A., & Eckstein, F. (1985). The use of phosphorothioate-modified DNA in restriction enzyme reactions to prepare nicked DNA.. Nucleic acids research, 13(24), 8749-8764. doi:10.1093/nar/13.24.8749DOI: 10.1093/nar/13.24.8749
Synthesis of d(GC) and d(CG) octamers containing alternating phosphorothioate linkages: effect of the phosphorothioate group on the B-Z transition. (Journal article)
Cosstick, R., & Eckstein, F. (1985). Synthesis of d(GC) and d(CG) octamers containing alternating phosphorothioate linkages: effect of the phosphorothioate group on the B-Z transition.. Biochemistry, 24(14), 3630-3638. doi:10.1021/bi00335a035DOI: 10.1021/bi00335a035
1984
Fluorescent labelling of tRNA and oligodeoxynucleotides using T4 RNA ligase. (Journal article)
Cosstick, R., McLaughlin, L. W., & Eckstein, F. (1984). Fluorescent labelling of tRNA and oligodeoxynucleotides using T4 RNA ligase.. Nucleic acids research, 12(4), 1791-1810. doi:10.1093/nar/12.4.1791DOI: 10.1093/nar/12.4.1791
