Photo of Prof Rick Cosstick

Prof Rick Cosstick BSc, PhD

Professor and Dean of the School of Physical Sciences Chemistry

    Publications

    2019

    Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors (Journal article)

    Kershaw, N. M., Byrne, D. P., Parsons, H., Berry, N. G., Fernig, D. G., Eyers, P. A., & Cosstick, R. (2019). Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors. RSC ADVANCES, 9(55), 32165-32173. doi:10.1039/c9ra07567d

    DOI: 10.1039/c9ra07567d

    2018

    Chemistry of the 8-Nitroguanine DNA Lesion: Reactivity, Labelling and Repair (Journal article)

    Alexander, K. J., McConville, M., Williams, K. R., Luzyanin, K. V., O'Neil, I. A., & Cosstick, R. (2018). Chemistry of the 8-Nitroguanine DNA Lesion: Reactivity, Labelling and Repair. Chemistry: A European Journal, 24(12), 3013-3020. doi:10.1002/chem.201705541

    DOI: 10.1002/chem.201705541

    2017

    SERS and SERRS Detection of the DNA Lesion 8-Nitroguanine: A Self-Labeling Modification (Journal article)

    Dick, S., Bell, S. E. J., Alexander, K. J., O'Neil, I. A., & Cosstick, R. (2017). SERS and SERRS Detection of the DNA Lesion 8-Nitroguanine: A Self-Labeling Modification. Chemistry (Weinheim an der Bergstrasse, Germany), 23(44), 10663-10669. doi:10.1002/chem.201701791

    DOI: 10.1002/chem.201701791

    2016

    Tautomerism in 8-Nitroguanosine Studied by NMR and Theoretical Calculations (Journal article)

    Barbosa, T. M., Rittner, R., Alexander, K., Cosstick, R., & Abraham, R. J. (2016). Tautomerism in 8-Nitroguanosine Studied by NMR and Theoretical Calculations. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 35(2), 53-63. doi:10.1080/15257770.2015.1114127

    DOI: 10.1080/15257770.2015.1114127

    2015

    Nicked-site substrates for a serine recombinase reveal enzyme–DNA communications and an essential tethering role of covalent enzyme–DNA linkages (Journal article)

    Olorunniji, F. J., McPherson, A. L., Pavlou, H. J., McIlwraith, M. J., Brazier, J. A., Cosstick, R., & Stark, W. M. (2015). Nicked-site substrates for a serine recombinase reveal enzyme–DNA communications and an essential tethering role of covalent enzyme–DNA linkages. Nucleic Acids Research, 43(12), 6134-6143. doi:10.1093/nar/gkv521

    DOI: 10.1093/nar/gkv521

    Stabilization of a Bimolecular Triplex by 3'-S-Phosphorothiolate Modifications: An NMR and UV Thermal Melting Investigation (Journal article)

    Evans, K., Bhamra, I., Wheelhouse, R. T., Arnold, J. R. P., Cosstick, R., & Fisher, J. (2015). Stabilization of a Bimolecular Triplex by 3'-S-Phosphorothiolate Modifications: An NMR and UV Thermal Melting Investigation. Chemistry - A European Journal, 21(19), 7278-7284. doi:10.1002/chem.201500369

    DOI: 10.1002/chem.201500369

    Probing the Run-On Oligomer of Activated SgrAI Bound to DNA (Journal article)

    Shah, S., Sanchez, J., Stewart, A., Piperakis, M. M., Cosstick, R., Nichols, C., . . . Horton, N. C. (2015). Probing the Run-On Oligomer of Activated SgrAI Bound to DNA. PLOS ONE, 10(4). doi:10.1371/journal.pone.0124783

    DOI: 10.1371/journal.pone.0124783

    2013

    Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation (Journal article)

    La Pensee, L., Sabbani, S., Sharma, R., Bhamra, I., Shore, E., Chadwick, A. E., . . . O'Neill, P. M. (2013). Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation. CHEMMEDCHEM, 8(5), 709-718. doi:10.1002/cmdc.201200536

    DOI: 10.1002/cmdc.201200536

    Thermal stabilisation of RNA·RNA duplexes and G-quadruplexes by phosphorothiolate linkages. (Journal article)

    Piperakis, M. M., Gaynor, J. W., Fisher, J., & Cosstick, R. (2013). Thermal stabilisation of RNA·RNA duplexes and G-quadruplexes by phosphorothiolate linkages.. Organic & biomolecular chemistry, 11(6), 966-974. doi:10.1039/c2ob26940f

    DOI: 10.1039/c2ob26940f

    2012

    Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine † (Journal article)

    Bhamra, I., Compagnone-Post, P., O’Neil, I. A., Iwanejko, L. A., Bates, A. D., & Cosstick, R. (2012). Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine †. Nucleic Acids Research, 40(21), 11126-11138. doi:10.1093/nar/gks799

    DOI: 10.1093/nar/gks799

    Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine. (Journal article)

    Bhamra, I., Compagnone-Post, P., O'Neil, I. A., Iwanejko, L. A., Bates, A. D., & Cosstick, R. (2012). Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine.. Nucleic acids research, 40(21), 11126-11138. doi:10.1093/nar/gks799

    DOI: 10.1093/nar/gks799

    2011

    Dinucleotides containing 3'-S-phosphorothiolate linkages. (Journal article)

    Gaynor, J. W., & Cosstick, R. (2011). Dinucleotides containing 3'-S-phosphorothiolate linkages.. Methods in molecular biology (Clifton, N.J.), 764, 17-30. doi:10.1007/978-1-61779-188-8_2

    DOI: 10.1007/978-1-61779-188-8_2

    2010

    A novel mechanism for the scission of double-stranded DNA: BfiI cuts both 3'-5' and 5'-3' strands by rotating a single active site (Journal article)

    Sasnauskas, G., Zakrys, L., Zaremba, M., Cosstick, R., Gaynor, J. W., Halford, S. E., & Siksnys, V. (2010). A novel mechanism for the scission of double-stranded DNA: BfiI cuts both 3'-5' and 5'-3' strands by rotating a single active site. NUCLEIC ACIDS RESEARCH, 38(7), 2399-2410. doi:10.1093/nar/gkp1194

    DOI: 10.1093/nar/gkp1194

    Reverse-direction (5 '-> 3 ') synthesis of oligonucleotides containing a 3 '-S-phosphorothiolate linkage and 3 '-terminal 3 '-thionucleosides (Journal article)

    Gaynor, J. W., Piperakis, M. M., Fisher, J., & Cosstick, R. (2010). Reverse-direction (5 '-> 3 ') synthesis of oligonucleotides containing a 3 '-S-phosphorothiolate linkage and 3 '-terminal 3 '-thionucleosides. ORGANIC & BIOMOLECULAR CHEMISTRY, 8(6), 1463-1470. doi:10.1039/b923545k

    DOI: 10.1039/b923545k

    RNA interference: a chemist's perspective (Journal article)

    Gaynor, J. W., Campbell, B. J., & Cosstick, R. (2010). RNA interference: a chemist's perspective. CHEMICAL SOCIETY REVIEWS, 39(11), 4169-4184. doi:10.1039/b920362c

    DOI: 10.1039/b920362c

    2009

    Antitumour and antimalarial activity of artemisinin-acridine hybrids (Journal article)

    Jones, M., Mercer, A. E., Stocks, P. A., La Pensee, L. J. I., Cosstick, R., Park, B. K., . . . O'Neill, P. M. (2009). Antitumour and antimalarial activity of artemisinin-acridine hybrids. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(7), 2033-2037. doi:10.1016/j.bmcl.2009.02.028

    DOI: 10.1016/j.bmcl.2009.02.028

    Antitumour and antimalarial activity of artemisinin–acridine hybrids (Journal article)

    Jones, M., Mercer, A. E., Stocks, P. A., La Pensée, L. J. I., Cosstick, R., Park, B. K., . . . O’Neill, P. M. (2009). Antitumour and antimalarial activity of artemisinin–acridine hybrids. Bioorganic & Medicinal Chemistry Letters, 19(7), 2033-2037. doi:10.1016/j.bmcl.2009.02.028

    DOI: 10.1016/j.bmcl.2009.02.028

    Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P-falciparum malaria parasites and HL-60 cancer cells (Journal article)

    Chadwick, J., Mercer, A. E., Park, B. K., Cosstick, R., & O'Neill, P. M. (2009). Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P-falciparum malaria parasites and HL-60 cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY, 17(3), 1325-1338. doi:10.1016/j.bmc.2008.12.017

    DOI: 10.1016/j.bmc.2008.12.017

    Nitrobenzyl Phototrigger for Fast Protein Folding Processes (Journal article)

    Whynes, R., Gonzales Barriuso, M., Cosstick, R., & Volk, M. (2009). Nitrobenzyl Phototrigger for Fast Protein Folding Processes. Biophysical Journal, Supple, 324a.

    2008

    Foldamers derived from nucleoside beta-amino acids: a new twist on the DNA helix. (Journal article)

    Cosstick, R., Threlfall, R., & Fisher, J. (2008). Foldamers derived from nucleoside beta-amino acids: a new twist on the DNA helix.. Nucleic acids symposium series (2004), (52), 313-314. doi:10.1093/nass/nrn158

    DOI: 10.1093/nass/nrn158

    Incorporation of 3'-S-phosphorothiolates into RNA: potential applications in RNAi. (Journal article)

    Gaynor, J., Fisher, J., Campbell, B., & Cosstick, R. (2008). Incorporation of 3'-S-phosphorothiolates into RNA: potential applications in RNAi.. Nucleic acids symposium series (2004), (52), 319-320. doi:10.1093/nass/nrn161

    DOI: 10.1093/nass/nrn161

    Towards fluorous-phase synthesis of nucleoside beta-peptides. (Journal article)

    Threlfall, R., Cosstick, R., & Wada, T. (2008). Towards fluorous-phase synthesis of nucleoside beta-peptides.. Nucleic acids symposium series (2004), (52), 337-338. doi:10.1093/nass/nrn170

    DOI: 10.1093/nass/nrn170

    The effect of 2'-fluorine substitutions on DNA i-motif conformation and stability. (Journal article)

    Fenna, C. P., Wilkinson, V. J., Arnold, J. R. P., Cosstick, R., & Fisher, J. (2008). The effect of 2'-fluorine substitutions on DNA i-motif conformation and stability.. Chemical communications (Cambridge, England), (30), 3567-3569. doi:10.1039/b804833a

    DOI: 10.1039/b804833a

    Synthesis, Properties and Application of Nucleic Acids Containing Phosphorothiolate Linkages (Journal article)

    Cosstick, R., & Gaynor, J. (2008). Synthesis, Properties and Application of Nucleic Acids Containing Phosphorothiolate Linkages. Current Organic Chemistry, 12(4), 291-308. doi:10.2174/138527208783743769

    DOI: 10.2174/138527208783743769

    Synthesis, properties and application of nucleic acids containing phosphorothiolate linkages (Journal article)

    Gaynor, J. W., & Cosstick, R. (2008). Synthesis, properties and application of nucleic acids containing phosphorothiolate linkages. Current Organic Chemistry, 12(4), 291-308.

    Peptides derived from nucleoside beta-amino acids form an unusual 8-helix. (Journal article)

    Threlfall, R., Davies, A., Howarth, N. M., Fisher, J., & Cosstick, R. (2008). Peptides derived from nucleoside beta-amino acids form an unusual 8-helix.. Chemical communications (Cambridge, England), (5), 585-587. doi:10.1039/b714350h

    DOI: 10.1039/b714350h

    Incorporation of 3'-S-phosphorothiolates into RNA; potential applications in RNAi (Journal article)

    Gaynor, J. W., Fisher, J., Campbell, B., & Cosstick, R. (2008). Incorporation of 3'-S-phosphorothiolates into RNA; potential applications in RNAi. Nucleic Acids Symposium Series, 52(1), 319-320.

    2007

    Foldamers derived from nucleoside beta-amino acids: PNA Or DNA? Can we have both in one place? (Journal article)

    Threlfall, R., Davies, A., Howarth, N., & Cosstick, R. (2007). Foldamers derived from nucleoside beta-amino acids: PNA Or DNA? Can we have both in one place?. Nucleosides, nucleotides & nucleic acids, 26(6-7), 611-614. doi:10.1080/15257770701490399

    DOI: 10.1080/15257770701490399

    Stabilization of multi-stranded nucleic acid structures using 3'-S-phosphorothiolate linkages. (Journal article)

    Cosstick, R., Buckingham, J., Brazier, J., & Fisher, J. (2007). Stabilization of multi-stranded nucleic acid structures using 3'-S-phosphorothiolate linkages.. Nucleosides, nucleotides & nucleic acids, 26(6-7), 555-558. doi:10.1080/15257770701490001

    DOI: 10.1080/15257770701490001

    Synthesis of 3 '-S-phosphorothiolate oligonucleotides for their potential use in RNA interference (Journal article)

    Gaynor, J. W., Brazier, J., & Cosstick, R. (2007). Synthesis of 3 '-S-phosphorothiolate oligonucleotides for their potential use in RNA interference. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 26(6-7), 709-712. doi:10.1080/15257770701490753

    DOI: 10.1080/15257770701490753

    Duplex stability of DNA.DNA and DNA.RNA duplexes containing 3'-S-phosphorothiolate linkages. (Journal article)

    Bentley, J., Brazier, J. A., Fisher, J., & Cosstick, R. (2007). Duplex stability of DNA.DNA and DNA.RNA duplexes containing 3'-S-phosphorothiolate linkages.. Organic & biomolecular chemistry, 5(22), 3698-3702. doi:10.1039/b713292a

    DOI: 10.1039/b713292a

    Enzymatic disassembly of DNA-gold nanostructures (Journal article)

    Kanaras, A. G., Wang, Z., Brust, M., Cosstick, R., & Bates, A. D. (2007). Enzymatic disassembly of DNA-gold nanostructures. SMALL, 3(4), 590-594. doi:10.1002/smll.200600494

    DOI: 10.1002/smll.200600494

    NMR studies of the conformational effect of single and double 3 '-S-phosphorothiolate substitutions within deoxythymidine trinucleotides (Journal article)

    Jayakumar, H. K., Buckingham, J. L., Brazier, J. A., Berry, N. G., Cosstick, R., & Fisher, J. (2007). NMR studies of the conformational effect of single and double 3 '-S-phosphorothiolate substitutions within deoxythymidine trinucleotides. MAGNETIC RESONANCE IN CHEMISTRY, 45(4), 340-345. doi:10.1002/mrc.1977

    DOI: 10.1002/mrc.1977

    Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity. (Journal article)

    Beckman, J., Kincaid, K., Hocek, M., Spratt, T., Engels, J., Cosstick, R., & Kuchta, R. D. (2007). Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity.. Biochemistry, 46(2), 448-460. doi:10.1021/bi061243s

    DOI: 10.1021/bi061243s

    Incorporation of a S-glycosidic linkage into a glyconucleoside changes the conformational preference of both furanose sugars. (Journal article)

    Buckingham, J., Brazier, J. A., Fisher, J., & Cosstick, R. (2007). Incorporation of a S-glycosidic linkage into a glyconucleoside changes the conformational preference of both furanose sugars.. Carbohydrate research, 342(1), 16-22. doi:10.1016/j.carres.2006.11.007

    DOI: 10.1016/j.carres.2006.11.007

    Site-specific ligation of DNA-modified gold nanoparticles activated by the restriction enzyme StyI (Journal article)

    Kanaras, A. G., Wang, Z., Hussain, I., Brust, M., Cosstick, R., & Bates, A. D. (2007). Site-specific ligation of DNA-modified gold nanoparticles activated by the restriction enzyme StyI. SMALL, 3(1), 67-70. doi:10.1002/smll.200600464

    DOI: 10.1002/smll.200600464

    Syntheses of 2'-C-amidoalkyl and 2'-C-cyanoalkyl containing oligodeoxyribonucleotides and assessment of their hybridisation affinity for complementary DNA and RNA (Journal article)

    Brennan, L., Cosstick, R., O'Neil, I. A., & Van Aerschot, A. (2007). Syntheses of 2'-C-amidoalkyl and 2'-C-cyanoalkyl containing oligodeoxyribonucleotides and assessment of their hybridisation affinity for complementary DNA and RNA. Tetrahedron, 63(3), 577-585. doi:10.1016/j.tet.2006.11.024

    DOI: 10.1016/j.tet.2006.11.024

    Synthesis of the 3 '-thio-nucleosides and subsequent automated synthesis of oligodeoxynucleotides containing a 3 '-S-phosphorothiolate linkage (Journal article)

    Gaynor, J. W., Bentley, J., & Cosstick, R. (2007). Synthesis of the 3 '-thio-nucleosides and subsequent automated synthesis of oligodeoxynucleotides containing a 3 '-S-phosphorothiolate linkage. NATURE PROTOCOLS, 2(12), 3122-3135. doi:10.1038/nprot.2007.451

    DOI: 10.1038/nprot.2007.451

    The Biochemical and Physiological Genesis of Alliin in Garlic (Journal article)

    Jones, M. G., Colin, H. A., Tregova, A., Trueman, L., Brown, L., Cosstick, R., . . . Thomas, B. (2007). The Biochemical and Physiological Genesis of Alliin in Garlic. Medicinal and Aromatic Plant Science and Biotechnology, 1(1).

    2006

    A combined top-down bottom-up approach for introducing nanoparticle networks into nanoelectrode gaps (Journal article)

    Xu, C., van Zalinge, H., Pearson, J. L., Glidle, A., Cooper, J. M., Cumming, D. R. S., . . . Nichols, R. J. (2006). A combined top-down bottom-up approach for introducing nanoparticle networks into nanoelectrode gaps. NANOTECHNOLOGY, 17(14), 3333-3339. doi:10.1088/0957-4484/17/14/001

    DOI: 10.1088/0957-4484/17/14/001

    Effect of low storage temperature on some of the flavour precursors in garlic (Allium sativum). (Journal article)

    Hughes, J., Collin, H. A., Tregova, A., Tomsett, A. B., Cosstick, R., & Jones, M. G. (2006). Effect of low storage temperature on some of the flavour precursors in garlic (Allium sativum).. Plant foods for human nutrition (Dordrecht, Netherlands), 61(2), 81-85. doi:10.1007/s11130-006-0018-4

    DOI: 10.1007/s11130-006-0018-4

    Construction and characterization of a gold nanoparticle wire assembled using Mg2+-dependent RNA-RNA interactions. (Journal article)

    Bates, A. D., Callen, B. P., Cooper, J. M., Cosstick, R., Geary, C., Glidle, A., . . . Cumming, D. R. S. (2006). Construction and characterization of a gold nanoparticle wire assembled using Mg2+-dependent RNA-RNA interactions.. Nano letters, 6(3), 445-448. doi:10.1021/nl052316g

    DOI: 10.1021/nl052316g

    Gold nanoparticle wires made using RNA-based self-assembly (Journal article)

    Cumming, D. R. S., Bates, A. D., Callen, B. P., Cooper, J. M., Cosstick, R., Geary, C., . . . Xu, C. (2006). Gold nanoparticle wires made using RNA-based self-assembly. Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures, 24(6), 3196. doi:10.1116/1.2363404

    DOI: 10.1116/1.2363404

    2005

    Stabilization of the DNA I-motif structure by incorporation of 3'-S-phosphorothiolate linkages. (Journal article)

    Brazier, J. A., Fisher, J., & Cosstick, R. (2005). Stabilization of the DNA I-motif structure by incorporation of 3'-S-phosphorothiolate linkages.. Angewandte Chemie (International ed. in English), 45(1), 114-117. doi:10.1002/anie.200503110

    DOI: 10.1002/anie.200503110

    Mechanism of the Escherichia coli DNA T:G-mismatch endonuclease (Vsr protein) probed with thiophosphate-containing oligodeoxynucleotides. (Journal article)

    Elliott, S. L., Brazier, J., Cosstick, R., & Connolly, B. A. (2005). Mechanism of the Escherichia coli DNA T:G-mismatch endonuclease (Vsr protein) probed with thiophosphate-containing oligodeoxynucleotides.. Journal of molecular biology, 353(3), 692-703. doi:10.1016/j.jmb.2005.08.048

    DOI: 10.1016/j.jmb.2005.08.048

    Control of DNA conformation using 3'-S-phosphorothiolate-modified linkages. (Journal article)

    Buckingham, J., Sabbagh, G., Brazier, J., Fisher, J., & Cosstick, R. (2005). Control of DNA conformation using 3'-S-phosphorothiolate-modified linkages.. Nucleosides, nucleotides & nucleic acids, 24(5-7), 491-495. doi:10.1081/ncn-200061776

    DOI: 10.1081/ncn-200061776

    Studies on the attachment of DNA to silica-coated nanoparticles through a Diels-Alder reaction (Journal article)

    Proupin-Perez, M., Cosstick, R., Liz-Marzan, L. M., Salgueirino-Maceira, V., & Brust, M. (2005). Studies on the attachment of DNA to silica-coated nanoparticles through a Diels-Alder reaction. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 24(5-7), 1075-1079. doi:10.1081/NCN-200059170

    DOI: 10.1081/NCN-200059170

    SULFUR BIOCHEMISTRY OF GARLIC: THE BIOSYNTHESIS OF FLAVOR PRECURSORS (Conference Paper)

    Collin, H. A., Hughes, J., Tregova, A., Milne, J. G. C., van der Werff, G., Wilkinson, M., . . . Thomas, B. (2005). SULFUR BIOCHEMISTRY OF GARLIC: THE BIOSYNTHESIS OF FLAVOR PRECURSORS. In Acta Horticulturae (pp. 165-172). International Society for Horticultural Science (ISHS). doi:10.17660/actahortic.2005.688.20

    DOI: 10.17660/actahortic.2005.688.20

    Synthesis of the flavour precursor, alliin, in garlic tissue cultures. (Journal article)

    Hughes, J., Tregova, A., Tomsett, A. B., Jones, M. G., Cosstick, R., & Collin, H. A. (2005). Synthesis of the flavour precursor, alliin, in garlic tissue cultures.. Phytochemistry, 66(2), 187-194. doi:10.1016/j.phytochem.2004.11.009

    DOI: 10.1016/j.phytochem.2004.11.009

    2004

    Synthesis and transcription studies on 5'-triphosphates derived from 2'-C-branched-uridines: 2'-homouridine-5'-triphosphate is a substrate for T7 RNA polymerase. (Journal article)

    Pavey, J. B. J., Lawrence, A. J., O'Neil, I. A., Vortler, S., & Cosstick, R. (2004). Synthesis and transcription studies on 5'-triphosphates derived from 2'-C-branched-uridines: 2'-homouridine-5'-triphosphate is a substrate for T7 RNA polymerase.. Organic & biomolecular chemistry, 2(6), 869-875. doi:10.1039/b314348a

    DOI: 10.1039/b314348a

    Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10 beta-(2-hydroxyethyl)deoxoartemisinin (Journal article)

    Jeyadevan, J. P., Bray, P. G., Chadwick, J., Mercer, A. E., Byrne, A., Ward, S. A., . . . O'Neill, P. M. (2004). Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10 beta-(2-hydroxyethyl)deoxoartemisinin. JOURNAL OF MEDICINAL CHEMISTRY, 47(5), 1290-1298. doi:10.1021/jm030974c

    DOI: 10.1021/jm030974c

    Enzymatic DNA processing on gold nanoparticles (Journal article)

    Wang, Z. X., Kanaras, A. G., Bates, A. D., Cosstick, R., & Brust, M. (2004). Enzymatic DNA processing on gold nanoparticles. JOURNAL OF MATERIALS CHEMISTRY, 14(4), 578-580. doi:10.1039/b314328g

    DOI: 10.1039/b314328g

    Synthesis of phosphorothioamidites derived from 3'-thio-3'-deoxythymidine and 3'-thio-2',3'-dideoxycytidine and the automated synthesis of oligodeoxynucleotides containing a 3'-S-phosphorothiolate linkage. (Journal article)

    Sabbagh, G., Fettes, K. J., Gosain, R., O'Neil, I. A., & Cosstick, R. (2004). Synthesis of phosphorothioamidites derived from 3'-thio-3'-deoxythymidine and 3'-thio-2',3'-dideoxycytidine and the automated synthesis of oligodeoxynucleotides containing a 3'-S-phosphorothiolate linkage.. Nucleic acids research, 32(2), 495-501. doi:10.1093/nar/gkh189

    DOI: 10.1093/nar/gkh189

    NMR and UV studies of 3'-S-phosphorothiolate modified DNA in a DNA : RNA hybrid dodecamer duplex; implications for antisense drug design. (Journal article)

    Beevers, A. P. G., Fettes, K. J., Sabbagh, G., Murad, F. K., Arnold, J. R. P., Cosstick, R., & Fisher, J. (2004). NMR and UV studies of 3'-S-phosphorothiolate modified DNA in a DNA : RNA hybrid dodecamer duplex; implications for antisense drug design.. Organic & biomolecular chemistry, 2(1), 114-119. doi:10.1039/b311923h

    DOI: 10.1039/b311923h

    2003

    Towards multistep nanostructure synthesis: Programmed enzymatic self-assembly of DNA/gold systems (Journal article)

    Kanaras, A. G., Wang, Z. X., Bates, A. D., Cosstick, R., & Brust, M. (2003). Towards multistep nanostructure synthesis: Programmed enzymatic self-assembly of DNA/gold systems. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 42(2), 191-+. doi:10.1002/anie.200390075

    DOI: 10.1002/anie.200390075

    Studies on 2'-alpha-C-carboxyalkyl nucleosides and their application to a stereocontrolled nucleobase exchange process. (Journal article)

    Fehring, V., Knights, S., Chan, M. -Y., O'Neil, I. A., & Cosstick, R. (2003). Studies on 2'-alpha-C-carboxyalkyl nucleosides and their application to a stereocontrolled nucleobase exchange process.. Organic & biomolecular chemistry, 1(1), 123-128. doi:10.1039/b208786n

    DOI: 10.1039/b208786n

    2002

    Probing the effect of a 3'-S-phosphorothiolate link on the conformation of a DNA:RNA hybrid; implications for antisense drug design. (Journal article)

    Beevers, A. P. G., Fettes, K. J., O'Neil, I. A., Roberts, S. M., Arnold, J. R. P., Cosstick, R., & Fisher, J. (2002). Probing the effect of a 3'-S-phosphorothiolate link on the conformation of a DNA:RNA hybrid; implications for antisense drug design.. Chemical communications (Cambridge, England), (14), 1458-1459. doi:10.1039/b203582k

    DOI: 10.1039/b203582k

    2001

    Novel macrocycles derived from nucleosides. (Journal article)

    Calcerrada-Muñoz, N., O'Neil, I., & Cosstick, R. (2001). Novel macrocycles derived from nucleosides.. Nucleosides, nucleotides & nucleic acids, 20(4-7), 1347-1350. doi:10.1081/ncn-100002552

    DOI: 10.1081/ncn-100002552

    Solid-phase synthesis of oligodeoxynucleotides containing 3'-S-phosphorothiolate linkages. (Journal article)

    Fettes, K. J., O'Neil, I., Roberts, S. M., & Cosstick, R. (2001). Solid-phase synthesis of oligodeoxynucleotides containing 3'-S-phosphorothiolate linkages.. Nucleosides, nucleotides & nucleic acids, 20(4-7), 1351-1354. doi:10.1081/ncn-100002553

    DOI: 10.1081/ncn-100002553

    The synthesis of, and studies on, 2'-C-modified nucleotides. (Journal article)

    Brennan, L., Fettes, K. J., O'Neil, I. A., & Cosstick, R. (2001). The synthesis of, and studies on, 2'-C-modified nucleotides.. Nucleosides, nucleotides & nucleic acids, 20(4-7), 1339-1341. doi:10.1081/ncn-100002550

    DOI: 10.1081/ncn-100002550

    2000

    A novel stereo-controlled nucleobase exchange process for the synthesis of 2'-C-branched nucleosides (Journal article)

    Fehring, V., Chan, M. Y., O’Neil, I. A., & Cosstick, R. (2000). A novel stereo-controlled nucleobase exchange process for the synthesis of 2'-C-branched nucleosides. Journal of the Chemical Society, Perkin Transactions 1, (19), 3185-3187. doi:10.1039/b007099h

    DOI: 10.1039/b007099h

    Hydrolytic Reactions of the cis-methyl ester of 3 '-deoxy-3 '-thiothymidine 3 ',5 '-cyclic(phosphorothiolate) (Journal article)

    Elzagheid, M. I., Mattila, K., Oivanen, M., Jones, B. C. N. M., Cosstick, R., & Lonnberg, H. (2000). Hydrolytic Reactions of the cis-methyl ester of 3 '-deoxy-3 '-thiothymidine 3 ',5 '-cyclic(phosphorothiolate). EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (10), 1987-1991.

    1999

    Hydrolytic Reactions of 3'-Deoxy-3'-thioinosylyl-(3'? >5')-uridine; An RNA Dinucleotide Containing a 3'-S-Phosphorothiolate Linkage (Journal article)

    Elzagheid, M. I., Oivanen, M., Klika, K. D., Jones, B. C. N. M., Cosstick, R., & Lönnberg, H. (1999). Hydrolytic Reactions of 3'-Deoxy-3'-thioinosylyl-(3'? >5')-uridine; An RNA Dinucleotide Containing a 3'-S-Phosphorothiolate Linkage. Nucleosides and Nucleotides, 18(9), 2093-2108. doi:10.1080/07328319908044866

    DOI: 10.1080/07328319908044866

    Hydrolytic Reactions of an RNA Dinucleotide Containing a 3'-S-Phosphorothiolate Linkage (Journal article)

    Elzagheid, M., Oivanen, M., Colin, B., Jones, N. M., Cosstick, R., & Lönnberg, H. (1999). Hydrolytic Reactions of an RNA Dinucleotide Containing a 3'-S-Phosphorothiolate Linkage. Nucleosides and Nucleotides, 18(6-7), 1265-1266. doi:10.1080/07328319908044687

    DOI: 10.1080/07328319908044687

    Conformational analysis of 3'-S-PO3-linked ribo- and deoxyribodinucleoside monophosphates (Journal article)

    Beevers, A. P. G., Witch, E. M., Jones, B. C. N. M., Cosstick, R., Arnold, J. R. P., & Fisher, J. (1999). Conformational analysis of 3'-S-PO3-linked ribo- and deoxyribodinucleoside monophosphates. MAGNETIC RESONANCE IN CHEMISTRY, 37(11), 814-820.

    Synthesis and duplex stability of oligodeoxyribonucleotides containing a 2 '-> 5 '-amide linkage (Journal article)

    Chan, M. Y., Fairhurst, R. A., Collingwood, S. P., Fisher, J., Arnold, J. R. P., Cosstick, R., & O'Neil, I. A. (1999). Synthesis and duplex stability of oligodeoxyribonucleotides containing a 2 '-> 5 '-amide linkage. Journal of the Chemical Society-Perkin Transactions 1 (3): 315-320 FEB 7 1999, (3), 315-320.

    1998

    The synthesis of a novel 2',3'-cyclic phosphate derived from 2'-homouridine (Journal article)

    Pavey, J. B. J., Cosstick, R., & O'Neil, I. A. (1998). The synthesis of a novel 2',3'-cyclic phosphate derived from 2'-homouridine. Tetrahedron Letters, 39(48), 8923-8924. doi:10.1016/s0040-4039(98)01952-2

    DOI: 10.1016/s0040-4039(98)01952-2

    The synthesis of 2'-homouridine, its incorporation into a dinucleoside monophosphate and hydrolytic behaviour of the dimer (Journal article)

    Pavey, J. B. J., Lawrence, A. J., Potter, A. J., Cosstick, R., & O'Neil, I. A. (1998). The synthesis of 2'-homouridine, its incorporation into a dinucleoside monophosphate and hydrolytic behaviour of the dimer. Tetrahedron Letters, 39(38), 6967-6970. doi:10.1016/s0040-4039(98)01478-6

    DOI: 10.1016/s0040-4039(98)01478-6

    1997

    A second catalytic metal ion in group I ribozyme. (Journal article)

    Weinstein, L. B., Jones, B. C., Cosstick, R., & Cech, T. R. (1997). A second catalytic metal ion in group I ribozyme.. Nature, 388(6644), 805-808. doi:10.1038/42076

    DOI: 10.1038/42076

    Dinucleoside Monophosphate Analogues Containing Disulfide Linkages (Journal article)

    Witch, E. M., & Cosstick, R. (1997). Dinucleoside Monophosphate Analogues Containing Disulfide Linkages. Nucleosides and Nucleotides, 16(7-9), 1555-1558. doi:10.1080/07328319708006228

    DOI: 10.1080/07328319708006228

    The RuvC protein dimer resolves Holliday junctions by a dual incision mechanism that involves base-specific contacts. (Journal article)

    Shah, R., Cosstick, R., & West, S. C. (1997). The RuvC protein dimer resolves Holliday junctions by a dual incision mechanism that involves base-specific contacts.. The EMBO journal, 16(6), 1464-1472. doi:10.1093/emboj/16.6.1464

    DOI: 10.1093/emboj/16.6.1464

    Synthesis, structure and reactions of uridine 2'-C,3'-O-gamma-butyrolactone: versatile intermediate for the synthesis of 2'-C-branched nucleosides (Journal article)

    Lawrence, A. J., Pavey, J. B. J., Chan, M. Y., Fairhurst, R. A., Collingwood, S. P., Fisher, J., . . . ONeil, I. A. (1997). Synthesis, structure and reactions of uridine 2'-C,3'-O-gamma-butyrolactone: versatile intermediate for the synthesis of 2'-C-branched nucleosides. Journal of the Chemical Society-Perkin Transactions 1, (18), 2761-2767.

    The synthesis of 2'-C-functionalised nucleosides for incorporation into catalytic RNA (Journal article)

    Lawrence, A. J., Pavey, J. B. J., ONeil, I. A., & Cosstick, R. (1997). The synthesis of 2'-C-functionalised nucleosides for incorporation into catalytic RNA. Nucleosides and Nucleotides, 16(7-9), 497-1501.

    1996

    Synthesis and Properties of 2‘-Deoxy-2‘-a-C-branched Nucleosides and Nucleotides (Journal article)

    Lawrence, A. J., Pavey, J. B. J., Cosstick, R., & O'Neil, I. A. (1996). Synthesis and Properties of 2‘-Deoxy-2‘-a-C-branched Nucleosides and Nucleotides. The Journal of Organic Chemistry, 61(26), 9213-9222. doi:10.1021/jo9614607

    DOI: 10.1021/jo9614607

    Synthesis and characterization of an RNA dinucleotide containing a 3'-S-phosphorothiolate linkage (Journal article)

    Weinstein, L. B., Earnshaw, D. J., Cosstick, R., & Cech, T. R. (1996). Synthesis and characterization of an RNA dinucleotide containing a 3'-S-phosphorothiolate linkage. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 118(43), 0341-10350.

    Synthesis and structure of S-nucleosidyl S-aryl disulfides and their reaction with phosphites (Journal article)

    Higson, A. P., Scott, G. K., Earnshaw, D. J., Baxter, A. D., Taylor, R. A., & Cosstick, R. (1996). Synthesis and structure of S-nucleosidyl S-aryl disulfides and their reaction with phosphites. Tetrahedron, 52(3), 1027-1034. doi:10.1016/0040-4020(95)00936-1

    DOI: 10.1016/0040-4020(95)00936-1

    1995

    The specific binding of Escherichia coli integration host factor involves both major and minor grooves of DNA. (Journal article)

    Wang, S., Cosstick, R., Gardner, J. F., & Gumport, R. I. (1995). The specific binding of Escherichia coli integration host factor involves both major and minor grooves of DNA.. Biochemistry, 34(40), 13082-13090. doi:10.1021/bi00040a020

    DOI: 10.1021/bi00040a020

    1993

    Thermodynamic stability and drug-binding properties of oligodeoxyribonucleotide duplexes containing 3-deazaadenine:thymine base pairs. (Journal article)

    Lever, C., Li, X., Cosstick, R., Ebel, S., & Brown, T. (1993). Thermodynamic stability and drug-binding properties of oligodeoxyribonucleotide duplexes containing 3-deazaadenine:thymine base pairs.. Nucleic acids research, 21(8), 1743-1746. doi:10.1093/nar/21.8.1743

    DOI: 10.1093/nar/21.8.1743

    1992

    Sequence- and strand-specific cleavage in oligodeoxyribonucleotides and DNA containing 3'-thiothymidine. (Journal article)

    Vyle, J. S., Connolly, B. A., Kemp, D., & Cosstick, R. (1992). Sequence- and strand-specific cleavage in oligodeoxyribonucleotides and DNA containing 3'-thiothymidine.. Biochemistry, 31(11), 3012-3018. doi:10.1021/bi00126a024

    DOI: 10.1021/bi00126a024

    1991

    Properties of the diadenosine tetraphosphate nucleoside analogue, bis (N6-adenosyl)dodecane, and its possible use in the treatment of disorders of purine metabolism. (Journal article)

    Chen, H., Cosstick, R., & McLennan, A. G. (1991). Properties of the diadenosine tetraphosphate nucleoside analogue, bis (N6-adenosyl)dodecane, and its possible use in the treatment of disorders of purine metabolism.. Biochemical Society transactions, 19(2), 123S. doi:10.1042/bst019123s

    DOI: 10.1042/bst019123s

    Synthesis of cross-linked nucleosides as potential inhibitors of thymidine kinase. (Journal article)

    Cosstick, R., & Nayyar, S. Z. (1991). Synthesis of cross-linked nucleosides as potential inhibitors of thymidine kinase.. Nucleic acids symposium series, (24), 292.

    Synthesis of oligonucleotides containing 3-deaza-2'-deoxyadenosine. Interaction of the oligonucleotides with the drug distamycin A. (Journal article)

    Cosstick, R., & Lever, C. (1991). Synthesis of oligonucleotides containing 3-deaza-2'-deoxyadenosine. Interaction of the oligonucleotides with the drug distamycin A.. Nucleic acids symposium series, (24), 291.

    1990

    Incorporation of a complete set of deoxyadenosine and thymidine analogues suitable for the study of protein nucleic acid interactions into oligodeoxynucleotides. Application to the EcoRV restriction endonuclease and modification methylase. (Journal article)

    Newman, P. C., Nwosu, V. U., Williams, D. M., Cosstick, R., Seela, F., & Connolly, B. A. (1990). Incorporation of a complete set of deoxyadenosine and thymidine analogues suitable for the study of protein nucleic acid interactions into oligodeoxynucleotides. Application to the EcoRV restriction endonuclease and modification methylase.. Biochemistry, 29(42), 9891-9901. doi:10.1021/bi00494a020

    DOI: 10.1021/bi00494a020

    Interaction of the EcoRV restriction endonuclease with the deoxyadenosine and thymidine bases in its recognition hexamer d(GATATC). (Journal article)

    Newman, P. C., Williams, D. M., Cosstick, R., Seela, F., & Connolly, B. A. (1990). Interaction of the EcoRV restriction endonuclease with the deoxyadenosine and thymidine bases in its recognition hexamer d(GATATC).. Biochemistry, 29(42), 9902-9910. doi:10.1021/bi00494a021

    DOI: 10.1021/bi00494a021

    Molecular recognition in the minor groove of the DNA helix. Studies on the synthesis of oligonucleotides and polynucleotides containing 3-deaza-2'-deoxyadenosine. Interaction of the oligonucleotides with the restriction endonuclease EcoRV. (Journal article)

    Cosstick, R., Li, X., Tuli, D. K., Williams, D. M., Connolly, B. A., & Newman, P. C. (1990). Molecular recognition in the minor groove of the DNA helix. Studies on the synthesis of oligonucleotides and polynucleotides containing 3-deaza-2'-deoxyadenosine. Interaction of the oligonucleotides with the restriction endonuclease EcoRV.. Nucleic acids research, 18(16), 4771-4778.

    Synthesis and properties of dithymidine phosphate analogues containing 3'-thiothymidine. (Journal article)

    Cosstick, R., & Vyle, J. S. (1990). Synthesis and properties of dithymidine phosphate analogues containing 3'-thiothymidine.. Nucleic acids research, 18(4), 829-835. doi:10.1093/nar/18.4.829

    DOI: 10.1093/nar/18.4.829

    Aplastic anaemia associated with organochlorine pesticide: case reports and review of evidence. (Journal article)

    Rugman, F. P., & Cosstick, R. (1990). Aplastic anaemia associated with organochlorine pesticide: case reports and review of evidence.. Journal of clinical pathology, 43(2), 98-101. doi:10.1136/jcp.43.2.98

    DOI: 10.1136/jcp.43.2.98

    Synthesis of bridged dinucleosides (Journal article)

    Agathocleous, D. C., Bulman Page, P. C., Cosstick, R., Galpin, I. J., McLennan, A. G., & Prescott, M. (1990). Synthesis of bridged dinucleosides. Tetrahedron, 46(6), 2047-2058. doi:10.1016/s0040-4020(01)89771-4

    DOI: 10.1016/s0040-4020(01)89771-4

    1989

    The Inhibition of Adenosine Kinase by a,?-Di (Adenosin -N6- YL) Alkanes1 (Journal article)

    Prescott, M., McLennan, A. G., Agathocleous, D. C., Bulman Page, P. C., Cosstick, R., & Galpin, I. J. (1989). The Inhibition of Adenosine Kinase by a,?-Di (Adenosin -N6- YL) Alkanes1. Nucleosides and Nucleotides, 8(2), 297-303. doi:10.1080/07328318908054174

    DOI: 10.1080/07328318908054174

    1987

    An approach to the stereoselective synthesis of Sp-dinucleoside phosphorothioates using phosphotriester chemistry. (Journal article)

    Cosstick, R., & Williams, D. M. (1987). An approach to the stereoselective synthesis of Sp-dinucleoside phosphorothioates using phosphotriester chemistry.. Nucleic acids research, 15(23), 9921-9932. doi:10.1093/nar/15.23.9921

    DOI: 10.1093/nar/15.23.9921

    1986

    Chiral phosphorothioate analogues of B-DNA. The crystal structure of Rp-d[Gp(S)CpGp(S)CpGp(S)C]. (Journal article)

    Cruse, W. B., Salisbury, S. A., Brown, T., Cosstick, R., Eckstein, F., & Kennard, O. (1986). Chiral phosphorothioate analogues of B-DNA. The crystal structure of Rp-d[Gp(S)CpGp(S)CpGp(S)C].. Journal of molecular biology, 192(4), 891-905. doi:10.1016/0022-2836(86)90035-5

    DOI: 10.1016/0022-2836(86)90035-5

    1985

    The use of phosphorothioate-modified DNA in restriction enzyme reactions to prepare nicked DNA. (Journal article)

    Taylor, J. W., Schmidt, W., Cosstick, R., Okruszek, A., & Eckstein, F. (1985). The use of phosphorothioate-modified DNA in restriction enzyme reactions to prepare nicked DNA.. Nucleic acids research, 13(24), 8749-8764. doi:10.1093/nar/13.24.8749

    DOI: 10.1093/nar/13.24.8749

    Synthesis of d(GC) and d(CG) octamers containing alternating phosphorothioate linkages: effect of the phosphorothioate group on the B-Z transition. (Journal article)

    Cosstick, R., & Eckstein, F. (1985). Synthesis of d(GC) and d(CG) octamers containing alternating phosphorothioate linkages: effect of the phosphorothioate group on the B-Z transition.. Biochemistry, 24(14), 3630-3638. doi:10.1021/bi00335a035

    DOI: 10.1021/bi00335a035

    1984

    Fluorescent labelling of tRNA and oligodeoxynucleotides using T4 RNA ligase. (Journal article)

    Cosstick, R., McLaughlin, L. W., & Eckstein, F. (1984). Fluorescent labelling of tRNA and oligodeoxynucleotides using T4 RNA ligase.. Nucleic acids research, 12(4), 1791-1810. doi:10.1093/nar/12.4.1791

    DOI: 10.1093/nar/12.4.1791