Photo of Dr James Hobson

Dr James Hobson BSc (Hons) MSc MRes PhD

Research Associate Chemistry

Publications

2019

Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations (Journal article)

Hobson, J. J., Curley, P., Savage, A. C., Al-khouja, A., Siccardi, M., Flexner, C., . . . Rannard, S. P. (n.d.). Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations. Nanoscale Advances, 1(11), 4301-4307. doi:10.1039/c9na00529c

DOI: 10.1039/c9na00529c

Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies (Journal article)

Hobson, J. J., Al-Khouja, A., Curley, P., Meyers, D., Flexner, C., Siccardi, M., . . . Rannard, S. P. (2019). Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-019-09354-z

DOI: 10.1038/s41467-019-09354-z

2018

The potential value of nanomedicine and novel oral dosage forms in the treatment of HIV. (Journal article)

Hobson, J. J., Owen, A., & Rannard, S. P. (2018). The potential value of nanomedicine and novel oral dosage forms in the treatment of HIV. NANOMEDICINE, 13(16), 1963-1965. doi:10.2217/nnm-2018-0182

DOI: 10.2217/nnm-2018-0182

Solid drug nanoparticles synthesised using spontaneous nanoprecipitation of tenofovir disoproxil fumerate: From proof of concept to in vivo pharmacokinetics of improved oral dosage (Conference Paper)

Hobson, J., Curley, P., Al-khouja, A., Siccardi, M., Flexner, C., Meyers, C., . . . Rannard, S. (2018). Solid drug nanoparticles synthesised using spontaneous nanoprecipitation of tenofovir disoproxil fumerate: From proof of concept to in vivo pharmacokinetics of improved oral dosage. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 256. Retrieved from http://gateway.webofknowledge.com/

Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems (Journal article)

Hobson, J., Edwards, S., Slater, R., Martin, P., Owen, A., & Rannard, S. P. (2018). Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems. RSC Advances. doi:10.1039/c8ra01944d

DOI: 10.1039/c8ra01944d

Development of Prodrug Approaches for Long-Acting Nanoformulations of Emtricitabine-Based Regimens (Conference Paper)

Al-Khouja, A., Hobson, J. J., Henriquez, S., Meyers, D., Curley, P., Siccardi, M., . . . Meyers, C. L. F. (2018). Development of Prodrug Approaches for Long-Acting Nanoformulations of Emtricitabine-Based Regimens. In FASEB JOURNAL Vol. 32. Retrieved from http://gateway.webofknowledge.com/

2017

In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line (Journal article)

Curley, P., Giardiello, M., Liptrott, N. J., Dickens, D., Moss, D. M., Hobson, J. J., . . . Owen, A. (2017). In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line. Journal of Interdisciplinary Nanomedicine, 2(3), 157-169. doi:10.1002/jin2.32

DOI: 10.1002/jin2.32

Development of prodrug approaches for long-acting nanoformulations of emtricitabine-based regimens (Conference Paper)

Al-Khouja, A., Hobson, J., Meyers, D., Curley, P., Siliciano, J., Siliciano, R., . . . Meyers, C. (2017). Development of prodrug approaches for long-acting nanoformulations of emtricitabine-based regimens. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 254. Retrieved from http://gateway.webofknowledge.com/

New branched polymer architectures for nano and macro emulsion stabilisation and targeting/delivery of therapeutic molecules (Conference Paper)

Hobson, J., Edwards, S., Owen, A., & Rannard, S. (2017). New branched polymer architectures for nano and macro emulsion stabilisation and targeting/delivery of therapeutic molecules. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 254. Retrieved from http://gateway.webofknowledge.com/

Semi-solid pro-drug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs for combination HIV therapies (Conference Paper)

Hobson, J., Al-Khouja, A., Curley, P., Flexner, C., Meyers, C., Owen, A., & Rannard, S. (2017). Semi-solid pro-drug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs for combination HIV therapies. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 254. Retrieved from http://gateway.webofknowledge.com/

Solid drug nanoparticles synthesised using water-in-oil emulsion templating and nanoprecipitation: From proof of concept to in vitro validation of long acting depot (Conference Paper)

Hobson, J., Curley, P., Al-khouja, A., Meyers, C., Flexner, C., Owen, A., & Rannard, S. (2017). Solid drug nanoparticles synthesised using water-in-oil emulsion templating and nanoprecipitation: From proof of concept to in vitro validation of long acting depot. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 254. Retrieved from http://gateway.webofknowledge.com/

Long Acting Release of Water-Soluble Compounds Formulated as Solid Drug Nanoparticles Dispersed in Injectable Oils (Conference Paper)

Hobson, J. J., Curley, P., Al-Khouja, A., Freel Meyers, C., Flexner, C., Owen, A., & Rannard, S. (2017, July 10). Long Acting Release of Water-Soluble Compounds Formulated as Solid Drug Nanoparticles Dispersed in Injectable Oils. In Royal Society of Chemistry UK Colloids 2017. Manchester, UK.

Simulating intestinal transporter and enzyme activity in a physiologically based pharmacokinetic model for tenofovir disoproxil fumarate. (Journal article)

Moss, D. M., Domanico, P., Watkins, M., Park, S., Randolph, R., Wring, S., . . . Owen, A. (2017). Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 61(7). doi:10.1128/AAC.00105-17

DOI: 10.1128/aac.00105-17

A Proof-of-Concept for Long Acting Release of Water-Soluble Compounds as Solid Drug Nanoparticles Dispersed in Injectable Oils (Conference Paper)

Hobson, J. J., Widger, B., Farrance, K., Curley, P., Al-Khouja, A., Flexner, C., . . . Rannard, S. (2017, April 3). A Proof-of-Concept for Long Acting Release of Water-Soluble Compounds as Solid Drug Nanoparticles Dispersed in Injectable Oils. In European Nanomedicine Conference. Kings College, London.

Improving Intestinal Permeation of Poorly Water Soluble Drugs Using Polymer Stabilised Oil-in-Water Nanoemulsions (Conference Paper)

Hobson, J. J., Slater, R., Martin, P., Owen, A., & Rannard, S. (2017, January 26). Improving Intestinal Permeation of Poorly Water Soluble Drugs Using Polymer Stabilised Oil-in-Water Nanoemulsions. In Royal Society of Chemisty: Chemical Nanosciences and Nanotecnology Network Meeting. Keele Hall.

2016

Development and Characterisation of Antiretroviral Drugs Encapsulated in Polymer Stabilised Oil-in-Water Nanoemulsions (Conference Paper)

Hobson, J. J., Slater, R., Martin, P., Owen, A., & Rannard, S. (2016, September 25). Development and Characterisation of Antiretroviral Drugs Encapsulated in Polymer Stabilised Oil-in-Water Nanoemulsions. In 4th Congress on Innovation in Drug Delivery. Juan-Le-Pins, Antibes, France.

Development and Characterisation of Antiretroviral Drugs Encapsulated in Polymer Stabilised oil-in-water Nanoemulsions (Conference Paper)

Abstract (2016). In Journal of Interdisciplinary Nanomedicine Vol. 1 (pp. 35-82). Wiley. doi:10.1002/jin2.14

DOI: 10.1002/jin2.14

Nanoemulsions (Patent)

Rannard, S., Owen, A., Hobson, J., Liptrott, N., & Chambon, P. (2016, February 3). WO2016124925, Nanoemulsions.

2014

Development and characterisation of antiretroviral drugs encapsulated in polymer stabilised oil-in-water nanoemulsions (Thesis / Dissertation)

Hobson, J. (n.d.). Development and characterisation of antiretroviral drugs encapsulated in polymer stabilised oil-in-water nanoemulsions. (PhD Thesis, University of Liverpool).

2013

Immunological Safety Assessment and Viral Efficacy of Novel Pickering Stabilised Nanoemulsions Containing Lopinavir and Efavirenz (Conference Paper)

Hobson, J. J., Liptrott, N., Martin, P., Ford, J., Slater, R., Rannard, S., & Owen, A. (2013, June 23). Immunological Safety Assessment and Viral Efficacy of Novel Pickering Stabilised Nanoemulsions Containing Lopinavir and Efavirenz. In Clinical Nanomedicine and Targeted Medicine. Basel, Switzerland.

Prediction of Etravirine Pharmacogenetics using a Physiologically Based Pharmacokinetic approach (Conference Paper)

Siccardi, M., Olagunju, A., Curley, P., Hobson, J., Khoo, S., Back, D., & Owen, A. (2013). Prediction of Etravirine Pharmacogenetics using a Physiologically Based Pharmacokinetic approach. In 20th Conference on Retroviruses and Opportunistic Infections. Atlanta, USA.

2011

Development and Cytotoxic assessment of novel “Pickering-like” stabilisers for emulsion based delivery of Antiretroviral drugs (Poster)

Hobson, J. J., Slater, R., Rannard, S., & Owen, A. (n.d.). Development and Cytotoxic assessment of novel “Pickering-like” stabilisers for emulsion based delivery of Antiretroviral drugs. Poster session presented at the meeting of In Vitro Toxicology Society Annual Meeting. Liverpool, UK.