Welcome to the Centre for Proteome Research at The University of Liverpool. We are a well equipped laboratory led by two academics, addressing a range of challenges in proteomics and protein mass spectrometry as applied to biology and biomedical. In these pages, you will find a brief description of our capabilities, our research themes and projects, our publications and the team.

In addition to driving our own research, the CPR also operates under the auspices of the University of Liverpool Technology Directorate, as as Shared Research Facility. This means that we are very outward facing and very willing to engage with colleagues, both internal and external, and with industry, to apply our skills to a range of problems. Details on routes to access the SRF can also be found within these pages.
  • News
  • Proteomics Service
  • Publications

Welcome to new members of CPR
We're delighted to extend a warm welcome to new members of the group.

Joscelyn Saxby joins us from Birmingham, where she became an MS Imaging expert and brings that expertise to the group. Jos joins us to work on the CoPY project, in the first instance.

Sam Ferries, a PhD student working with Claire and Pat Eyers.

Amy Campbell, a PhD student working with Claire.

Karen Sanders, an M.Phil. student who joins us on a project on MS Imaging of equine tendons. Karen's degree was in biochemistry, but she then obtained a BVSc. After some years in practice, the lure of academia proved too strong.

Grace Loxley, an M.Res student who like Karen, has previously completed her first degree in Biochemistry here at Liverpool. Grace will be completing her project on urinary proteins in mouse lemurs, in collaboration with colleagues in Hanover.

Grant successes providing new instrumentation and capability
In 2015, we’ll be installing new instrumentation for a variety of projects. These have been funded by BBSRC, MRC and the University of Liverpool Technology Directorate. Claire led an application to the BBSRC ALERT 14 call (Claire Eyers (PI), Rob Beynon, Pat Eyers, Perdita Barran (Manchester), Kathryn Lilley (Cambridge) to establish advanced MS capability for top down proteomics and deep bottom up proteomics.

Rob was a co-applicant on the
MRC Clinical Research Capabilities and Technologies Initiative that will result in the installation of a new MS capability for metabolomics and a system for automated size or charge based quantitative western blotting. In addition, tis grant provided for the installation of a mass cytometer, and CPR will play an active role in delivering this advanced technology to users.

Congratulations, Professor Claire Eyers
We’re delighted to celebrate the promotion of Claire to full professorship in the Institute of Integrative Biology. Tempting to embark on a poetic stanza since ‘Chair’ and ‘Claire’ fit together so well!

Well done Claire, we’re hugely thrilled for you.

A short eulogy
The first week in May saw us bid '
au revoir' to our oldest instrument - the Waters QTOF micro. Bought in 2001, it was mainly purchased for peptide LCMS/MS and intact protein profiling. And boy, has it delivered! Over ten years later, it still functioned, meets its specifications and can still generate great data. It ran innumerable MUP profiles, and we're still looking at the data from this instrument.

Known locally as QTOFU, or more recently, as 'TOFU', it has a future life, with Prof Steve Taylor in Electrical Engineering [LINK]. We suspect there is life in the old thing yet (the analogies are not lost on the webmaster) and may well have a long and happpy retirement.

The first paper was from Julia Hayter on intact mass profiling [
LINK]. We showed that really quite complex protein mixtures could be resolved using a modest system of resolution 5,000, and after MaxEnt processing, were able to gain baseline resolution, and identify, many of the proteins in the biological system.

Bought with a BBSRC REI grant, we think that represents excellent value to the taxpayer!

Have a happy retirement, TOFU!