Photo of Professor Mandy Peffers

Professor Mandy Peffers BSc(Hons)MPhil PhD BVetMed FRCVS

Wellcome Trust Clinical Intermediate Fellow Musculoskeletal & Ageing Science

    Publications

    2021

    Sox9 Determines Translational Capacity During Early Chondrogenic Differentiation of ATDC5 Cells by Regulating Expression of Ribosome Biogenesis Factors and Ribosomal Proteins (Journal article)

    Caron, M. M. J., Eveque, M., Cillero-Pastor, B., Heeren, R. M. A., Housmans, B., Derks, K., . . . Welting, T. J. M. (2021). Sox9 Determines Translational Capacity During Early Chondrogenic Differentiation of ATDC5 Cells by Regulating Expression of Ribosome Biogenesis Factors and Ribosomal Proteins. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 9. doi:10.3389/fcell.2021.686096

    DOI: 10.3389/fcell.2021.686096

    Small-RNA Sequencing Reveals Altered Skeletal Muscle microRNAs and snoRNAs Signatures in Weanling Male Offspring from Mouse Dams Fed a Low Protein Diet during Lactation (Journal article)

    Kanakis, I., Alameddine, M., Folkes, L., Moxon, S., Myrtziou, I., Ozanne, S. E., . . . Vasilaki, A. (2021). Small-RNA Sequencing Reveals Altered Skeletal Muscle microRNAs and snoRNAs Signatures in Weanling Male Offspring from Mouse Dams Fed a Low Protein Diet during Lactation. CELLS, 10(5). doi:10.3390/cells10051166

    DOI: 10.3390/cells10051166

    Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome After Microfracture or Osteotomy (Journal article)

    Hulme, C. H., Peffers, M. J., Harrington, G. M. B., Wilson, E., Perry, J., Roberts, S., . . . Wright, K. T. (2021). Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome After Microfracture or Osteotomy. AMERICAN JOURNAL OF SPORTS MEDICINE, 49(6), 1512-1523. doi:10.1177/0363546521995565

    DOI: 10.1177/0363546521995565

    EPIGENETIC CHANGES IN AGEING HUMAN TENDON TISSUE (Conference Paper)

    Riasat, K., Cockell, S. J., Green, D. C., Pease, L. I., & Peffers, M. J. (2021). EPIGENETIC CHANGES IN AGEING HUMAN TENDON TISSUE. In OSTEOARTHRITIS AND CARTILAGE Vol. 29 (pp. S309-S310). Retrieved from http://gateway.webofknowledge.com/

    SYNOVIAL FLUID AND SERUM SMALL NON-CODING RNA SIGNATURES IN EQUINE OSTEOARTHRITIS (Conference Paper)

    Castanheira, C., James, V., Taylor, S., Skioldebrand, E., Clegg, P. D., & Peffers, M. J. (2021). SYNOVIAL FLUID AND SERUM SMALL NON-CODING RNA SIGNATURES IN EQUINE OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 29 (pp. S162). Retrieved from http://gateway.webofknowledge.com/

    Nuclear magnetic resonance spectroscopy of biofluids for osteoarthritis (Journal article)

    Clarke, E. J., Anderson, J. R., & Peffers, M. J. (2021). Nuclear magnetic resonance spectroscopy of biofluids for osteoarthritis. BRITISH MEDICAL BULLETIN, 137(1), 28-41. doi:10.1093/bmb/ldaa037

    DOI: 10.1093/bmb/ldaa037

    Small-RNA sequencing reveals altered skeletal muscle microRNAs and snoRNAs signatures in weanling male offspring from mouse dams fed a low protein diet during lactation (Journal article)

    Kanakis, I., Alameddine, M., Folkes, L., Moxon, S., Myrtziou, I., Ozanne, S., . . . Vasilaki, A. (2021). Small-RNA sequencing reveals altered skeletal muscle microRNAs and snoRNAs signatures in weanling male offspring from mouse dams fed a low protein diet during lactation. doi:10.1101/2021.02.22.432208

    DOI: 10.1101/2021.02.22.432208

    Equine synovial fluid small non-coding RNA signatures in early osteoarthritis (Journal article)

    Castanheira, C., Balaskas, P., Falls, C., Ashraf-Kharaz, Y., Clegg, P., Burke, K., . . . Peffers, M. J. (2021). Equine synovial fluid small non-coding RNA signatures in early osteoarthritis. BMC VETERINARY RESEARCH, 17(1). doi:10.1186/s12917-020-02707-7

    DOI: 10.1186/s12917-020-02707-7

    Identification of tissue-dependent proteins in knee OA synovial fluid (Journal article)

    Timur, U. T., Jahr, H., Anderson, J., Green, D. C., Emans, P. J., Smagul, A., . . . Welting, T. J. M. (2021). Identification of tissue-dependent proteins in knee OA synovial fluid. OSTEOARTHRITIS AND CARTILAGE, 29(1), 124-133. doi:10.1016/j.joca.2020.09.005

    DOI: 10.1016/j.joca.2020.09.005

    Small Nucleolar RNA Expression Profiling in Cartilage. (Chapter)

    Peffers, M. J., Cremers, A., & Welting, T. J. M. (2021). Small Nucleolar RNA Expression Profiling in Cartilage.. In Unknown Book (Vol. 2245, pp. 135-149). doi:10.1007/978-1-0716-1119-7_10

    DOI: 10.1007/978-1-0716-1119-7_10

    2020

    Epigenetic mechanisms in tendon ageing (Journal article)

    Riasat, K., Bardell, D., Goljanek-Whysall, K., Clegg, P., & Peffers, M. (n.d.). Epigenetic mechanisms in tendon ageing. British Medical Bulletin. doi:10.1093/bmb/ldaa023

    DOI: 10.1093/bmb/ldaa023

    Impaired chondrocyte U3 snoRNA expression in osteoarthritis impacts the chondrocyte protein translation apparatus (Journal article)

    Peffers, M. (2020). Impaired chondrocyte U3 snoRNA expression in osteoarthritis impacts the chondrocyte protein translation apparatus. Scientific Reports, 10. doi:10.1038/s41598-020-70453-9

    DOI: 10.1038/s41598-020-70453-9

    Small Non-Coding RNAome of Ageing Chondrocytes (Journal article)

    Balaskas, P., Green, J. A., Haqqi, T. M., Dyer, P., Kharaz, Y. A., Fang, Y., . . . Peffers, M. J. (2020). Small Non-Coding RNAome of Ageing Chondrocytes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(16). doi:10.3390/ijms21165675

    DOI: 10.3390/ijms21165675

    Ex-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study. (Journal article)

    Anderson, J. R., Phelan, M. M., Foddy, L., Clegg, P. D., & Peffers, M. J. (2020). Ex-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study.. Journal of proteome research. doi:10.1021/acs.jproteome.0c00143

    DOI: 10.1021/acs.jproteome.0c00143

    Optimization of Synovial Fluid Collection and Processing for NMR Metabolomics and LC-MS/MS Proteomics (Journal article)

    Anderson, J. R., Phelan, M. M., Rubio-Martinez, L. M., Fitzgerald, M. M., Jones, S. W., Clegg, P. D., & Peffers, M. J. (2020). Optimization of Synovial Fluid Collection and Processing for NMR Metabolomics and LC-MS/MS Proteomics. Journal of Proteome Research, 19(7), 2585-2597. doi:10.1021/acs.jproteome.0c00035

    DOI: 10.1021/acs.jproteome.0c00035

    SnoRNA signatures in cartilage ageing and osteoarthritis (Conference Paper)

    Peffers, M. J., Chabronova, A., Balaskas, P., Fang, Y., Dyer, P., Cremers, A., . . . Welting, T. J. M. (2020). SnoRNA signatures in cartilage ageing and osteoarthritis. In SCIENTIFIC REPORTS Vol. 10. doi:10.1038/s41598-020-67446-z

    DOI: 10.1038/s41598-020-67446-z

    SnoRNA signatures in cartilage ageing and osteoarthritis. (Journal article)

    Peffers, M. J., Chabronova, A., Balaskas, P., Fang, Y., Dyer, P., Cremers, A., . . . Welting, T. J. M. (2020). SnoRNA signatures in cartilage ageing and osteoarthritis.. Scientific Reports, 10. doi:10.1038/s41598-020-67446-z

    DOI: 10.1038/s41598-020-67446-z

    The use of technology in the subcategorisation of osteoarthritis: a Delphi study approach (Journal article)

    Mennan, C., Hopkins, T., Channon, A., Elliott, M., Johnstone, B., Kadir, T., . . . Roberts, S. (2020). The use of technology in the subcategorisation of osteoarthritis: a Delphi study approach. Osteoarthritis and Cartilage Open, 100081. doi:10.1016/j.ocarto.2020.100081

    DOI: 10.1016/j.ocarto.2020.100081

    Small RNA signatures of the anterior cruciate ligament from patients with knee joint osteoarthritis (Journal article)

    Kharaz, Y., Fang, Y., Welting, T., Peffers, M., & Comerford, E. (2020). Small RNA signatures of the anterior cruciate ligament from patients with knee joint osteoarthritis. doi:10.1101/2020.05.14.20101048

    DOI: 10.1101/2020.05.14.20101048

    Metabolomic and Proteomic Stratification of Equine Osteoarthritis (Journal article)

    Anderson, J., Phelan, M., Caamaño-Gutiérrez, E., Clegg, P., Rubio-Martinez, L., & Peffers, M. (2020). Metabolomic and Proteomic Stratification of Equine Osteoarthritis. doi:10.1101/2020.05.04.077305

    DOI: 10.1101/2020.05.04.077305

    IMPAIRED CHONDRCOYTE U3 SNORNA EXPRESSION IN OSTEOARTHRITIS AND ITS IMPACT ON THE CHONDROCYTE'S PROTEIN TRANSLATION APPARATUS (Conference Paper)

    Ripmeester, E. G., Caron, M. M., Balaskas, P., Dyer, P., Chabronova, A., van den Akker, G. G., . . . Welting, T. J. (2020). IMPAIRED CHONDRCOYTE U3 SNORNA EXPRESSION IN OSTEOARTHRITIS AND ITS IMPACT ON THE CHONDROCYTE'S PROTEIN TRANSLATION APPARATUS. In OSTEOARTHRITIS AND CARTILAGE Vol. 28 (pp. S47). Retrieved from http://gateway.webofknowledge.com/

    SMALL NON-CODING RNA SIGNATURES IN CARTILAGE AGEING (Conference Paper)

    Peffers, M. J., Balaskas, P., Fang, Y., Green, J. A., Haqqi, T. M., & Welting, T. J. (2020). SMALL NON-CODING RNA SIGNATURES IN CARTILAGE AGEING. In OSTEOARTHRITIS AND CARTILAGE Vol. 28 (pp. S347-S348). Retrieved from http://gateway.webofknowledge.com/

    SMALL NUCLEOLAR RNAS AS MEDIATORS OF OXIDATIVE STRESS IN CROSS SPECIES CARTILAGE AND OSTEOARTHRITIS (Conference Paper)

    Pimlott, Z., Hontoir, F., Kharaz, Y. A., Anderson, J., Dyer, P., Collins, J., . . . Peffers, M. J. (2020). SMALL NUCLEOLAR RNAS AS MEDIATORS OF OXIDATIVE STRESS IN CROSS SPECIES CARTILAGE AND OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 28 (pp. S342). Retrieved from http://gateway.webofknowledge.com/

    TGF-BETA INDUCES RIBOSOME ACTIVITY, ALTERS RIBOSOME COMPOSITION AND INHIBITS IRES-MEDIATED TRANSLATION IN CHONDROCYTES (Conference Paper)

    van den Akker, G. G., Surtel, D. A., Chabronova, A., Housmans, B. A., Caron, M. M., Peffers, M. J., & Welting, T. J. (2020). TGF-BETA INDUCES RIBOSOME ACTIVITY, ALTERS RIBOSOME COMPOSITION AND INHIBITS IRES-MEDIATED TRANSLATION IN CHONDROCYTES. In OSTEOARTHRITIS AND CARTILAGE Vol. 28 (pp. S348-S349). Retrieved from http://gateway.webofknowledge.com/

    THE ROLE OF SNORD116 IN CARTILAGE AGEING AND OSTEOARTHRITIS (Conference Paper)

    Peffers, M. J., Dale, A. G., Clough, H., Dyer, P., Ellis, J., Tew, S., . . . Welting, T. (2020). THE ROLE OF SNORD116 IN CARTILAGE AGEING AND OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 28 (pp. S342-S343). Retrieved from http://gateway.webofknowledge.com/

    Ex-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study (Journal article)

    Anderson, J., Phelan, M., Foddy, L., Clegg, P., & Peffers, M. (2020). Ex-VivoEquine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study. doi:10.1101/2020.03.03.974501

    DOI: 10.1101/2020.03.03.974501

    2019

    Translational regulation contributes to the secretory response of chondrocytic cells following exposure to Interleukin-1ß (Journal article)

    Mcdermott, B., Peffers, M., McDonagh, B., & Tew, S. R. (2019). Translational regulation contributes to the secretory response of chondrocytic cells following exposure to Interleukin-1ß. Journal of Biological Chemistry, 294(35), 13027-13029. doi:10.1074/jbc.RA118.006865

    DOI: 10.1074/jbc.RA118.006865

    Comparison of RNA extraction methods in equine synovial fluid in the determination of the expression of small non-coding RNAs (Conference Paper)

    Kharaz, Y. A., Comerford, E., & Peffers, M. (2019). Comparison of RNA extraction methods in equine synovial fluid in the determination of the expression of small non-coding RNAs. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A23). Retrieved from http://gateway.webofknowledge.com/

    Defining the role and mechanism of microRNAs in osteoarthritis (Conference Paper)

    Balaskas, P., Whysall, K., Clegg, P., Welting, T., & Peffers, M. (2019). Defining the role and mechanism of microRNAs in osteoarthritis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A10). Retrieved from http://gateway.webofknowledge.com/

    Small non-coding RNA transcriptome signatures of chondrocyte ageing (Conference Paper)

    Peffers, M. J., Smaghul, A., Balaska, P., Fang, Y., & Welting, S. T. M. (2019). Small non-coding RNA transcriptome signatures of chondrocyte ageing. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A30). Retrieved from http://gateway.webofknowledge.com/

    The articular cartilage proteome is dependent on zone, age and disease state (Conference Paper)

    Smagul, A., Simpson, D., Tew, S., & Peffers, M. J. (2019). The articular cartilage proteome is dependent on zone, age and disease state. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A36). Retrieved from http://gateway.webofknowledge.com/

    The synovial fluid proteome differentiates between septic and nonseptic articular pathologies (Journal article)

    Anderson, J. R., Smagul, A., Simpson, D., Clegg, P. D., Rubio-Martinez, L. M., & Peffers, M. J. (2019). The synovial fluid proteome differentiates between septic and nonseptic articular pathologies. JOURNAL OF PROTEOMICS, 202. doi:10.1016/j.jprot.2019.04.020

    DOI: 10.1016/j.jprot.2019.04.020

    Proteomic analysis of synovial fluid: current and potential uses to improve clinical outcomes. (Journal article)

    Peffers, M. J., Smagul, A., & Anderson, J. R. (2019). Proteomic analysis of synovial fluid: current and potential uses to improve clinical outcomes. EXPERT REVIEW OF PROTEOMICS, 16(4), 287-302. doi:10.1080/14789450.2019.1578214

    DOI: 10.1080/14789450.2019.1578214

    COMPARISON MICRORNAS EXPRESSION IN NORMAL AND RUPTURED CANINE CRUCIATE LIGAMENTS (Conference Paper)

    Kharaz, Y. A., Peffers, M., & Comerford, E. (2019). COMPARISON MICRORNAS EXPRESSION IN NORMAL AND RUPTURED CANINE CRUCIATE LIGAMENTS. In OSTEOARTHRITIS AND CARTILAGE Vol. 27 (pp. S477). doi:10.1016/j.joca.2019.02.524

    DOI: 10.1016/j.joca.2019.02.524

    THE GATE TO CONTROLLING CHONDROGENIC DIFFERENTIATION: TRANSCRIPTIONAL REGULATION BY SOX9 IN ATDC5 CELLS (Conference Paper)

    Caron, M. M., Derks, K., Sanderink, L., van Rhijn, L., Peffers, M., & Welting, T. (2019). THE GATE TO CONTROLLING CHONDROGENIC DIFFERENTIATION: TRANSCRIPTIONAL REGULATION BY SOX9 IN ATDC5 CELLS. In OSTEOARTHRITIS AND CARTILAGE Vol. 27 (pp. S196). doi:10.1016/j.joca.2019.02.303

    DOI: 10.1016/j.joca.2019.02.303

    The antiviral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion. (Journal article)

    Steinbusch, M. M. F., Caron, M. M. J., Surtel, D. A. M., van den Akker, G. G. H., van Dijk, P. J., Friedrich, F., . . . Welting, T. J. M. (2019). The antiviral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion.. The Journal of Biological Chemistry, 294(13), 5121-5136. doi:10.1074/jbc.ra119.007356

    DOI: 10.1074/jbc.ra119.007356

    Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy to diagnose osteoarthritis in equine serum. (Journal article)

    Paraskevaidi, M., Hook, P. D., Morais, C. L. M., Anderson, J. R., White, R., Martin-Hirsch, P. L., . . . Martin, F. L. (2019). Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy to diagnose osteoarthritis in equine serum.. Equine veterinary journal. doi:10.1111/evj.13115

    DOI: 10.1111/evj.13115

    Differences in plasma and peritoneal fluid proteomes identifies potential biomarkers associated with survival following strangulating small intestinal disease (Journal article)

    Bardell, D. A., Milner, P., Whysall, K., & Peffers, M. (2019). Differences in plasma and peritoneal fluid proteomes identifies potential biomarkers associated with survival following strangulating small intestinal disease. Equine Veterinary Journal. doi:10.1111/evj.13094

    DOI: 10.1111/evj.13094

    The antiviral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion (Journal article)

    Peffers, M. J. (2019). The antiviral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion. Journal of Biological Chemistry. doi:10.1074/jbc.RA119.007356

    DOI: 10.1074/jbc.RA119.007356

    2018

    Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs) (Conference Paper)

    Hulme, C. H., Wilson, E., Fuller, H. R., Roberts, S., Richardson, J. B., Gallacher, P., . . . Wright, K. T. (2018). Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs). In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A2). Retrieved from http://gateway.webofknowledge.com/

    Insulin-like growth factor binding protein (Igfbp6) is a cross-species transcriptomic tendon marker (Conference Paper)

    Mueller-Breckenridge, A. J., Turlo, A. J., Zamboulis, D., Peffers, M. J., & Clegg, P. D. (2018). Insulin-like growth factor binding protein (Igfbp6) is a cross-species transcriptomic tendon marker. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A2-A3). Retrieved from http://gateway.webofknowledge.com/

    1H NMR metabolomics identifies underlying inflammatory pathology in osteoarthritis and rheumatoid arthritis synovial joints (Journal article)

    Anderson, J., Chokesuwattanaskul, S., Phelan, M., Welting, T., Lian, L. Y., Peffers, M., & Wright, H. L. (2018). 1H NMR metabolomics identifies underlying inflammatory pathology in osteoarthritis and rheumatoid arthritis synovial joints. Journal of Proteome Research, 17(11), 3780-3790. doi:10.1021/acs.jproteome.8b00455

    DOI: 10.1021/acs.jproteome.8b00455

    Towards a toolkit for the assessment and monitoring of musculoskeletal ageing (Journal article)

    Kemp, G. J., Jackson, M. J., Mccloskey, E. V., Mathers, J. C., & Grp, C. I. M. A. T. W. (2018). Towards a toolkit for the assessment and monitoring of musculoskeletal ageing. AGE AND AGEING, 47(6), 774-777. doi:10.1093/ageing/afy078

    DOI: 10.1093/ageing/afy078

    Developing a toolkit for the assessment and monitoring of musculoskeletal ageing (Journal article)

    Kemp, G. J., Birrell, F., Clegg, P. D., Cuthbertson, D. J., De Vito, G., van Dieen, J. H., . . . Mathers, J. C. (2018). Developing a toolkit for the assessment and monitoring of musculoskeletal ageing. AGE AND AGEING, 47(suppl_4), iv1-iv19. doi:10.1093/ageing/afy143

    DOI: 10.1093/ageing/afy143

    Synovial Fluid Metabolites Differentiate between Septic and Nonseptic Joint Pathologies (Journal article)

    Anderson, J. R., Phelan, M. M., Clegg, P. D., Peffers, M. J., & Rubio-Martinez, L. M. (2018). Synovial Fluid Metabolites Differentiate between Septic and Nonseptic Joint Pathologies. Journal of Proteome Research, 17(8), 2735-2743. doi:10.1021/acs.jproteome.8b00190

    DOI: 10.1021/acs.jproteome.8b00190

    Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation (Journal article)

    Hulme, C. H., Wilson, E. L., Fuller, H. R., Roberts, S., Richardson, J. B., Gallacher, P., . . . Wright, K. T. (2018). Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation. ARTHRITIS RESEARCH & THERAPY, 20. doi:10.1186/s13075-018-1573-4

    DOI: 10.1186/s13075-018-1573-4

    A ROLE FOR SMALL NUCLEOLAR RNA HOST GENES IN CARTILAGE AGEING AND OSTEOARTHRITIS (Conference Paper)

    Peffers, M. J., Balaska, P., Dyers, P., Welting, T., & Cremers, A. (2018). A ROLE FOR SMALL NUCLEOLAR RNA HOST GENES IN CARTILAGE AGEING AND OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S160-S161). Retrieved from http://gateway.webofknowledge.com/

    A ROLE FOR THE SNORNA U3 IN THE ALTERED TRANSLATIONAL CAPACITY OF AGEING AND OSTEOARTHRITIC CHONDROCYTES (Conference Paper)

    Peffers, M. J., Ripmeester, E., Caron, M., Steinbusch, M., Balaskas, P., Cremers, A., . . . Welting, T. J. (2018). A ROLE FOR THE SNORNA U3 IN THE ALTERED TRANSLATIONAL CAPACITY OF AGEING AND OSTEOARTHRITIC CHONDROCYTES. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S45-S46). Retrieved from http://gateway.webofknowledge.com/

    ACUTE PHASE RESPONSE SIGNALLING IS ALTERED FOLLOWING CARTILAGE HARVEST IN NON-RESPONDERS TO AUTOLOGOUS CHONDROCYTE IMPLANTATION (Conference Paper)

    Hulme, C. H., Wilson, E. L., Fuller, H. R., Roberts, S. R., Richardson, J. B., Gallacher, P., . . . Wright, K. T. (2018). ACUTE PHASE RESPONSE SIGNALLING IS ALTERED FOLLOWING CARTILAGE HARVEST IN NON-RESPONDERS TO AUTOLOGOUS CHONDROCYTE IMPLANTATION. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S167). Retrieved from http://gateway.webofknowledge.com/

    COMPREHENSIVE EXPRESSION ANALYSIS OF SMALL NON CODING RNAS IN EARLY OSTEOARTHRITIS SYNOVIAL FLUID (Conference Paper)

    Peffers, M. J., Balaska, P., Fang, Y., Anderson, J., Burke, K., & Welting, T. (2018). COMPREHENSIVE EXPRESSION ANALYSIS OF SMALL NON CODING RNAS IN EARLY OSTEOARTHRITIS SYNOVIAL FLUID. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S186-S187). Retrieved from http://gateway.webofknowledge.com/

    DEFINING THE ROLE AND MECHANISMS OF MICRORNAS IN CARTILAGE AGEING AND DISEASE (Conference Paper)

    Balaskas, P., Goljanek-Whysall, K., Clegg, P., Welting, T., & Peffers, M. (2018). DEFINING THE ROLE AND MECHANISMS OF MICRORNAS IN CARTILAGE AGEING AND DISEASE. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S165). Retrieved from http://gateway.webofknowledge.com/

    IDENTIFICATION OF TISSUE-SPECIFIC BIOMARKERS IN KNEE OSTEOARTHRITIS SYNOVIAL FLUID: A PROTEOMIC APPROACH (Conference Paper)

    Timur, U., Jahr, H., Emans, P., van Rhijn, L., Peffers, M., & Welting, T. (2018). IDENTIFICATION OF TISSUE-SPECIFIC BIOMARKERS IN KNEE OSTEOARTHRITIS SYNOVIAL FLUID: A PROTEOMIC APPROACH. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S42). Retrieved from http://gateway.webofknowledge.com/

    Proteomic Analysis of Equine Plasma and Peritoneal Fluid in Strangulating Small Intestinal Disease (Conference Paper)

    Bardell, D., Peffers, M. J., & Milner, P. (2018). Proteomic Analysis of Equine Plasma and Peritoneal Fluid in Strangulating Small Intestinal Disease. In FASEB JOURNAL Vol. 32. Retrieved from http://gateway.webofknowledge.com/

    RIBOSOMAL PROFILING AND SECRETOME ANALYSIS IDENTIFY THAT INTERLEUKIN-1B DRIVEN CYTOKINE/CHEMOKINE RELEASE FROM CHONDROCYTIC CELLS IS UNDERPINNED BY DIFFERENTIAL TRANSLATION (Conference Paper)

    McDermott, B. T., Peffers, M. J., McDonagh, B., & Tew, S. R. (2018). RIBOSOMAL PROFILING AND SECRETOME ANALYSIS IDENTIFY THAT INTERLEUKIN-1B DRIVEN CYTOKINE/CHEMOKINE RELEASE FROM CHONDROCYTIC CELLS IS UNDERPINNED BY DIFFERENTIAL TRANSLATION. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S105). Retrieved from http://gateway.webofknowledge.com/

    STRATIFYING OSTEOARTHRITIS USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY PROTEOMIC ANALYSIS OF SYNOVIAL FLUID (Conference Paper)

    Anderson, J. R., Clegg, P. D., Rubio-Martinez, L. M., Riggs, C. M., & Peffers, M. J. (2018). STRATIFYING OSTEOARTHRITIS USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY PROTEOMIC ANALYSIS OF SYNOVIAL FLUID. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S171). Retrieved from http://gateway.webofknowledge.com/

    SYNOVIAL FLUID METABOLITE PROFILES DIFFER BETWEEN OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS (Conference Paper)

    Anderson, J. R., Chokesuwattanaskul, S., Phelan, M. P., Welting, T. J. M., Lian, L. -Y., Peffers, M. J., & Wright, H. L. (2018). SYNOVIAL FLUID METABOLITE PROFILES DIFFER BETWEEN OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS. In RHEUMATOLOGY Vol. 57. Retrieved from http://gateway.webofknowledge.com/

    THE EFFECT OF U3 SNORNA KNOCKDOWN ON THE CHONDROCYTE PROTEOME (Conference Paper)

    Smagul, A., Tew, S., & Peffers, M. J. (2018). THE EFFECT OF U3 SNORNA KNOCKDOWN ON THE CHONDROCYTE PROTEOME. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S165). Retrieved from http://gateway.webofknowledge.com/

    THE GATE TO CONTROLLING CHONDROGENIC DIFFERENTIATION: TRANSCRIPTIONAL REGULATION BY SOX9 IN ATDC5 CELLS (Conference Paper)

    Caron, M. M., Derks, K. W., Sanderink, L., van Rhijn, L. W., Peffers, M. J., & Welting, T. J. (2018). THE GATE TO CONTROLLING CHONDROGENIC DIFFERENTIATION: TRANSCRIPTIONAL REGULATION BY SOX9 IN ATDC5 CELLS. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S109). Retrieved from http://gateway.webofknowledge.com/

    THE ROLE OF MICRORNAS IN TENDON DYSFUNCTION (Conference Paper)

    Bardell, D., Peffers, M. J., Clegg, P. D., Molloy, A. P., & Goljanek-Whysall, K. (2018). THE ROLE OF MICRORNAS IN TENDON DYSFUNCTION. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S165-S166). Retrieved from http://gateway.webofknowledge.com/

    VIPERIN REGULATES CHONDROGENIC DIFFERENTIATION VIA CXCL10 PROTEIN SECRETION (Conference Paper)

    Steinbusch, M. M., Caroni, M. M., Surtel, D. A., van Dijk, P. J., Friedrich, F., Zabel, B., . . . Welting, T. J. (2018). VIPERIN REGULATES CHONDROGENIC DIFFERENTIATION VIA CXCL10 PROTEIN SECRETION. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S93). Retrieved from http://gateway.webofknowledge.com/

    Effects of stanozolol on normal and IL-1 beta-stimulated equine chondrocytes in vitro (Journal article)

    Martins, M. C., Peffers, M. J., Lee, K., & Rubio-Martinez, L. M. (2018). Effects of stanozolol on normal and IL-1 beta-stimulated equine chondrocytes in vitro. BMC VETERINARY RESEARCH, 14. doi:10.1186/s12917-018-1426-z

    DOI: 10.1186/s12917-018-1426-z

    Proteomic analysis of equine plasma and peritoneal fluid in strangulating small intestinal disease (Journal article)

    Bardell, D. A., Peffers, M. J., & Milner, P. I. (n.d.). Proteomic analysis of equine plasma and peritoneal fluid in strangulating small intestinal disease. The FASEB Journal.

    Biomarkers for equine joint injury and osteoarthritis (Journal article)

    McIlwraith, C. W., Kawcak, C. E., Frisbie, D. D., Little, C. B., Clegg, P. D., Peffers, M. J., . . . Kraus, V. B. (2018). Biomarkers for equine joint injury and osteoarthritis. JOURNAL OF ORTHOPAEDIC RESEARCH, 36(3), 823-831. doi:10.1002/jor.23738

    DOI: 10.1002/jor.23738

    Osteoarthritis year in review 2017: genetics and epigenetics (Journal article)

    Peffers, M. J., Balaskas, P., & Smagul, A. (2018). Osteoarthritis year in review 2017: genetics and epigenetics. OSTEOARTHRITIS AND CARTILAGE, 26(3), 304-311. doi:10.1016/j.joca.2017.09.009

    DOI: 10.1016/j.joca.2017.09.009

    The role of microRNA:target interactions in tendon dysfunction (Journal article)

    Bardell, D. A., Peffers, M. J., Clegg, P. D., Molloy, A., & Whysall, K. A. (n.d.). The role of microRNA:target interactions in tendon dysfunction. Osteoarthritis and Cartilage.

    Donor age affects proteome composition of tenocyte-derived engineered tendon (Journal article)

    Turlo, A. J., Kharaz, Y. A., Clegg, P. D., Anderson, J., & Peffers, M. J. (2018). Donor age affects proteome composition of tenocyte-derived engineered tendon. BMC BIOTECHNOLOGY, 18. doi:10.1186/s12896-018-0414-5

    DOI: 10.1186/s12896-018-0414-5

    2017

    Local anaesthetics or their combination with morphine and/or magnesium sulphate are toxic for equine chondrocytes and synoviocytes in vitro (Journal article)

    Rubio Martinez, L. M., Rioja, E., Castro Martins, M., Wipawee, S., Clegg, P., & Peffers, M. J. (2017). Local anaesthetics or their combination with morphine and/or magnesium sulphate are toxic for equine chondrocytes and synoviocytes in vitro. Arthritis Research and Therapy. doi:10.1186/s12917-017-1244-8

    DOI: 10.1186/s12917-017-1244-8

    Local anaesthetics or their combination with morphine and/or magnesium sulphate are toxic for equine chondrocytes and synoviocytes in vitro (Journal article)

    Rubio-Martinez, L. M., Rioja, E., Martins, M. C., Wipawee, S., Clegg, P., & Peffers, M. J. (2017). Local anaesthetics or their combination with morphine and/or magnesium sulphate are toxic for equine chondrocytes and synoviocytes in vitro. BMC VETERINARY RESEARCH, 13. doi:10.1186/s12917-017-1244-8

    DOI: 10.1186/s12917-017-1244-8

    Cross platform analysis of transcriptomic data identifies ageing has distinct and opposite effects on tendon in males and females (Journal article)

    Pease, L. I., Clegg, P. D., Proctor, C. J., Shanley, D. J., Cockell, S. J., & Peffers, M. J. (2017). Cross platform analysis of transcriptomic data identifies ageing has distinct and opposite effects on tendon in males and females. Scientific Reports, 7. doi:10.1038/s41598-017-14650-z

    DOI: 10.1038/s41598-017-14650-z

    MicroRNA Profiling in Cartilage Ageing (Journal article)

    Balaskas, P., Goljanek-Whysall, K., Clegg, P., Fang, Y., Cremers, A., Emans, P., . . . Peffers, M. (2017). MicroRNA Profiling in Cartilage Ageing. INTERNATIONAL JOURNAL OF GENOMICS, 2017. doi:10.1155/2017/2713725

    DOI: 10.1155/2017/2713725

    Identification of Equid herpesvirus 2 in tissue-engineered equine tendon. (Journal article)

    Wardle, R., Pullman, J. A., Haldenby, S., Ressel, L., Pope, M., Clegg, P. D., . . . Peffers, M. J. (2017). Identification of Equid herpesvirus 2 in tissue-engineered equine tendon.. Wellcome open research, 2, 60. doi:10.12688/wellcomeopenres.12176.2

    DOI: 10.12688/wellcomeopenres.12176.2

    Systems Approaches in Osteoarthritis: Identifying Routes to Novel Diagnostic and Therapeutic Strategies (Journal article)

    Mueller, A. J., Peffers, M. J., Proctor, C. J., & Clegg, P. D. (2017). Systems Approaches in Osteoarthritis: Identifying Routes to Novel Diagnostic and Therapeutic Strategies. JOURNAL OF ORTHOPAEDIC RESEARCH, 35(8), 1573-1588. doi:10.1002/jor.23563

    DOI: 10.1002/jor.23563

    Comparison between chaotropic and detergent-based sample preparation workflow in tendon for mass spectrometry analysis (Journal article)

    Ashraf Kharaz, Y., Zamboulis, D., Sander, K., Comerford, E., Clegg, P., & Peffers, M. (2017). Comparison between chaotropic and detergent-based sample preparation workflow in tendon for mass spectrometry analysis. Proteomics, 17(13-14). doi:10.1002/pmic.201700018

    DOI: 10.1002/pmic.201700018

    POOR CLINICAL RESPONSE TO AUTOLOGOUS CHONDROCYTE IMPLANTATION IS ASSOCIATED WITH A UNIQUE SYNOVIAL FLUID PROTEOME PROFILE (Conference Paper)

    Hulme, C. H., Wilson, E. L., Peffers, M. J., Peffers, M. J., Fuller, H., Roberts, S., . . . Wright, K. T. (2017). POOR CLINICAL RESPONSE TO AUTOLOGOUS CHONDROCYTE IMPLANTATION IS ASSOCIATED WITH A UNIQUE SYNOVIAL FLUID PROTEOME PROFILE. In OSTEOARTHRITIS AND CARTILAGE Vol. 25 (pp. S92). doi:10.1016/j.joca.2017.02.146

    DOI: 10.1016/j.joca.2017.02.146

    Autologous chondrocyte implantation-derived synovial fluids display distinct responder and non-responder proteomic profiles (Journal article)

    Hulme, C. H., Wilson, E. L., Peffers, M. J., Roberts, S., Simpson, D. M., Richardson, J. B., . . . Wright, K. T. (2017). Autologous chondrocyte implantation-derived synovial fluids display distinct responder and non-responder proteomic profiles. Arthritis Research and Therapy, 19. doi:10.1186/s13075-017-1336-7

    DOI: 10.1186/s13075-017-1336-7

    Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint (Journal article)

    Davidson, R., Gardner, S., Jupp, O., Bullough, A., Butters, S., Watts, L., . . . Clark, I. (2017). Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint. Scientific Reports, 7. doi:10.1038/s41598-017-03629-5

    DOI: 10.1038/s41598-017-03629-5

    THE EFFECT OF DONOR AGE ON ENGINEERED TENDON TISSUE DERIVED FROM TENOCYTES AND MESENCHYMAL STEM CELLS (Conference Paper)

    Turlo, A. J., Kharaz, Y. A., Clegg, P. D., Anderson, J., & Peffers, M. J. (2017). THE EFFECT OF DONOR AGE ON ENGINEERED TENDON TISSUE DERIVED FROM TENOCYTES AND MESENCHYMAL STEM CELLS. In OSTEOARTHRITIS AND CARTILAGE Vol. 25 (pp. S88). doi:10.1016/j.joca.2017.02.137

    DOI: 10.1016/j.joca.2017.02.137

    Neopeptide Analyser: A software tool for neopeptide discovery in proteomics data. (Journal article)

    Peffers, M., Jones, A. R., McCabe, A., & Anderson, J. (2017). Neopeptide Analyser: A software tool for neopeptide discovery in proteomics data.. Wellcome open research, 2, 24. doi:10.12688/wellcomeopenres.11275.1

    DOI: 10.12688/wellcomeopenres.11275.1

    YEAR IN REVIEW - GENETICS/GENOMICS AND EPIGENETICS (Conference Paper)

    Peffers, M. J. (2017). YEAR IN REVIEW - GENETICS/GENOMICS AND EPIGENETICS. In OSTEOARTHRITIS AND CARTILAGE Vol. 25 (pp. S7). doi:10.1016/j.joca.2017.02.026

    Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis (Journal article)

    Steinbusch, M. M. F., Fang, Y., Milner, P. I., Clegg, P. D., Young, D. A., Welting, T. J. M., & Peffers, M. J. (2017). Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis. Scientific reports, 7, 11 pages. doi:10.1038/srep43558

    DOI: 10.1038/srep43558

    2016

    A role for small nucleolar RNAs in musculoskeletal ageing and osteoarthritis (Conference Paper)

    Peffers, M., Steinbusch, M., Milner, P., Fang, Y., Young, D., Welting, T., & Clegg, P. (2016). A role for small nucleolar RNAs in musculoskeletal ageing and osteoarthritis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A11). Retrieved from http://gateway.webofknowledge.com/

    Comparison of protein extraction methods in tendon for mass spectrometry analysis (Conference Paper)

    Ashraf Kharaz, Y., Zamboulis, D., Sander, K., Comerford, E., Clegg, P., & Peffers, M. (2016). Comparison of protein extraction methods in tendon for mass spectrometry analysis. In International Journal of Experimental Pathology Vol. 9 (pp. A26). Chester University.

    Comparison of protein extraction methods in tendon for mass spectrometry analysis (Conference Paper)

    Kharaz, Y. A., Zamboulis, D., Sanders, K., Comerford, E., Clegg, P., & Peffers, M. (2016). Comparison of protein extraction methods in tendon for mass spectrometry analysis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A26). Retrieved from http://gateway.webofknowledge.com/

    A proteomic analysis of chondrogenic, osteogenic and tenogenic constructs from ageing mesenchymal stem cells (Journal article)

    Peffers, M. J., Collins, J., Loughlin, J., proctor, C., & Clegg, P. (2016). A proteomic analysis of chondrogenic, osteogenic and tenogenic constructs from ageing mesenchymal stem cells. Stem Cell Research & Therapy. doi:10.1186/s13287-016-0384-2

    DOI: 10.1186/s13287-016-0384-2

    Decoding the Regulatory Landscape of Ageing in Musculoskeletal Engineered Tissues Using Genome-Wide DNA Methylation and RNASeq (Journal article)

    Peffers, M. J., Goljanek-Whysall, K., Collins, J., Fang, Y., Rushton, M., Loughlin, J., . . . Clegg, P. D. (2016). Decoding the Regulatory Landscape of Ageing in Musculoskeletal Engineered Tissues Using Genome-Wide DNA Methylation and RNASeq. PLOS ONE, 11(8). doi:10.1371/journal.pone.0160517

    DOI: 10.1371/journal.pone.0160517

    Proteomic differences between native and tissue-engineered tendon and ligament (Journal article)

    Kharaz, Y. A., Tew, S. R., Peffers, M., Canty-Laird, E. G., & Comerford, E. (2016). Proteomic differences between native and tissue-engineered tendon and ligament. PROTEOMICS, 16(10), 1547-1556. doi:10.1002/pmic.201500459

    DOI: 10.1002/pmic.201500459

    BIG TASKS FOR SMALL RNAS; A NEW CLASS OF RNAS IN THE PATHGENESIS OF OSTEARTHRITIS (Conference Paper)

    Peffers, M. J., Clegg, P. D., Boothroyd, E., Cremer, A., Durtel, D. A., Caron, M. M., & Welting, T. J. (2016). BIG TASKS FOR SMALL RNAS; A NEW CLASS OF RNAS IN THE PATHGENESIS OF OSTEARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 24 (pp. S372). doi:10.1016/j.joca.2016.01.665

    DO BIOACTIVE COMPOUNDS FROM CRUCIFEROUS VEGETABLES REACH THE KNEE JOINT? (Conference Paper)

    Davidson, R. K., Gardner, S., Jupp, O., Bullough, A., Butters, S., Watts, L., . . . Clark, I. M. (2016). DO BIOACTIVE COMPOUNDS FROM CRUCIFEROUS VEGETABLES REACH THE KNEE JOINT?. In OSTEOARTHRITIS AND CARTILAGE Vol. 24 (pp. S459). doi:10.1016/j.joca.2016.01.838

    DOI: 10.1016/j.joca.2016.01.838

    IDENTIFICATION OF SERUM SNORNAS AS BIOMARKERS OF MUSCULOSKELETAL AGEING AND DISEASE (Conference Paper)

    Peffers, M. J., Milner, P. M., Fang, Y., Young, D., Whysall, K., & Clegg, P. D. (2016). IDENTIFICATION OF SERUM SNORNAS AS BIOMARKERS OF MUSCULOSKELETAL AGEING AND DISEASE. In OSTEOARTHRITIS AND CARTILAGE Vol. 24 (pp. S41-S42). doi:10.1016/j.joca.2016.01.099

    THE ROLE OF MICRORNAS IN OSTEOARTHRITIS AND AGEING RELATED FUNCTIONAL DECLINE IN JOINT TISSUE HOMEOSTASIS. (Conference Paper)

    House, L., Bou-Gharios, G., Peffers, M., Milner, P., Clegg, P. D., Young, D. A., & Whysall, K. A. (2016). THE ROLE OF MICRORNAS IN OSTEOARTHRITIS AND AGEING RELATED FUNCTIONAL DECLINE IN JOINT TISSUE HOMEOSTASIS.. In OSTEOARTHRITIS AND CARTILAGE Vol. 24 (pp. S63-S64). doi:10.1016/j.joca.2016.01.141

    DOI: 10.1016/j.joca.2016.01.141

    AGE-RELATED CHANGES IN MESENCHYMAL STEM CELLS IDENTIFIED USING A MULTI-OMICS APPROACH (Journal article)

    Peffers, M. J., Collins, J., Fang, Y., Goljanek-Whysall, K., Rushton, M., Loughlin, J., . . . Clegg, P. D. (2016). AGE-RELATED CHANGES IN MESENCHYMAL STEM CELLS IDENTIFIED USING A MULTI-OMICS APPROACH. EUROPEAN CELLS & MATERIALS, 31, 136-159. doi:10.22203/eCM.v031a10

    DOI: 10.22203/eCM.v031a10

    Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition (Journal article)

    Thorpe, C. T., Peffers, M. J., Simpson, D., Halliwell, E., Screen, H. R. C., & Clegg, P. D. (2016). Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition. Scientific Reports, 6. doi:10.1038/srep20455

    DOI: 10.1038/srep20455

    Characterization of Neopeptides in Equine Articular Cartilage Degradation (Journal article)

    Peffers, M. J., Thornton, D. J., & Clegg, P. D. (2016). Characterization of Neopeptides in Equine Articular Cartilage Degradation. JOURNAL OF ORTHOPAEDIC RESEARCH, 34(1), 106-120. doi:10.1002/jor.22963

    DOI: 10.1002/jor.22963

    Influence of Ageing on Tendon Homeostasis (Journal article)

    Birch, H. L., Peffers, M. J., & Clegg, P. D. (2016). Influence of Ageing on Tendon Homeostasis. METABOLIC INFLUENCES ON RISK FOR TENDON DISORDERS, 920, 247-260. doi:10.1007/978-3-319-33943-6_24

    DOI: 10.1007/978-3-319-33943-6_24

    2015

    Comprehensive protein profiling of synovial fluid in osteoarthritis following protein equalization (Journal article)

    Peffers, M., McDermott, B., Clegg, P., & Riggs, C. (2015). Comprehensive protein profiling of synovial fluid in osteoarthritis following protein equalization. Osteoarthritis and Cartilage, 23(7), 1204-1213. doi:10.1016/j.joca.2015.03.019

    DOI: 10.1016/j.joca.2015.03.019

    Transcriptome analysis of ageing in uninjured human Achilles tendon (Journal article)

    Peffers, M. J., Fang, Y., Cheung, K., Wei, T. K. J., Clegg, P. D., & Birch, H. L. (2015). Transcriptome analysis of ageing in uninjured human Achilles tendon. ARTHRITIS RESEARCH & THERAPY, 17. doi:10.1186/s13075-015-0544-2

    DOI: 10.1186/s13075-015-0544-2

    2014

    Transcriptome-Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes (Journal article)

    Tew, S., McDermott, B., Fentem, R. B., Peffers, M., & Clegg, P. (2014). Transcriptome-Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes. Arthritis and Rheumatology, 66(11), 3052-3061. doi:10.1002/art.38849

    DOI: 10.1002/art.38849

    Proteomic Analysis Reveals Age-related Changes in Tendon Matrix Composition, with Age- and Injury-specific Matrix Fragmentation (Journal article)

    Peffers, M., Thorpe, C., Collins, J., Eong, R., Wei, T., Screen, H., & Clegg, P. (2014). Proteomic Analysis Reveals Age-related Changes in Tendon Matrix Composition, with Age- and Injury-specific Matrix Fragmentation. The Journal of Biological Chemistry, 289(37), 25867-25878. doi:10.1074/jbc.M114.566554

    DOI: 10.1074/jbc.M114.566554

    Biosynthetic alterations in collagen production in ruptured canine anterior cruciate ligament (Conference Paper)

    Williamson, K. A., Peffers, M., Pettitt, R., Comerford, E., & Canty-Laird, E. G. (2014). Biosynthetic alterations in collagen production in ruptured canine anterior cruciate ligament. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 95 (pp. A37). Retrieved from http://gateway.webofknowledge.com/

    Characterisation of neopeptides in articular cartilage identifies novel degradative cleavage sites (Conference Paper)

    Peffers, M. J., McKnight, W., & Clegg, P. D. (2014). Characterisation of neopeptides in articular cartilage identifies novel degradative cleavage sites. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 95 (pp. A27-A28). Retrieved from http://gateway.webofknowledge.com/

    Matrix assisted laser desorption ionization mass spectrometry imaging identifies markers of ageing and osteoarthritic cartilage (Journal article)

    Peffers, M. J., Cillero-Pastor, B., Eijkel, G. B., Clegg, P. D., & Heeren, R. M. A. (2014). Matrix assisted laser desorption ionization mass spectrometry imaging identifies markers of ageing and osteoarthritic cartilage. Arthritis Research and Therapy, 16. doi:10.1186/ar4560

    DOI: 10.1186/ar4560

    Under pressure: the cell's response (Conference Paper)

    Under pressure: the cell's response (2014). In International Journal of Experimental Pathology Vol. 95 (pp. A1-A38). Wiley. doi:10.1111/iep.12078

    DOI: 10.1111/iep.12078

    COMPREHENSIVE PROTEIN PROFILING OF SYNOVIAL FLUID IN OSTEOARTHRITIS (Conference Paper)

    Peffers, M. J., McDermott, B. T., Riggs, C. M., & Clegg, P. D. (2014). COMPREHENSIVE PROTEIN PROFILING OF SYNOVIAL FLUID IN OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 22 (pp. S65-S66). doi:10.1016/j.joca.2014.02.134

    DOI: 10.1016/j.joca.2014.02.134

    POST 'TRANSCRIPTIONAL GENE REGULATION IN AGEING CARTILAGE AND CHONDROCYTES (Conference Paper)

    Peffers, M. J., Fentom, R., Tew, S. R., & Clegg, P. D. (2014). POST 'TRANSCRIPTIONAL GENE REGULATION IN AGEING CARTILAGE AND CHONDROCYTES. In OSTEOARTHRITIS AND CARTILAGE Vol. 22 (pp. S62-S63). doi:10.1016/j.joca.2014.02.128

    DOI: 10.1016/j.joca.2014.02.128

    Transcriptomic profiling of cartilage ageing. (Journal article)

    Peffers, M. J., Liu, X., & Clegg, P. D. (2014). Transcriptomic profiling of cartilage ageing.. Genomics data, 2, 27-28. doi:10.1016/j.gdata.2014.03.001

    DOI: 10.1016/j.gdata.2014.03.001

    2013

    Absolute Quantification of Selected Proteins in the Human Osteoarthritic Secretome (Journal article)

    Peffers, M. J., Beynon, R. J., & Clegg, P. D. (2013). Absolute Quantification of Selected Proteins in the Human Osteoarthritic Secretome. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 14(10), 20658-20681. doi:10.3390/ijms141020658

    DOI: 10.3390/ijms141020658

    MALDI imaging mass spectrometry reveals peptide markers of ageing and osteoarthritic cartilage (Conference Paper)

    Peffers, M. J., Cillero-Pastor, B., Eijkel, G., Clegg, P. D., & Heeren, R. M. A. (2013). MALDI imaging mass spectrometry reveals peptide markers of ageing and osteoarthritic cartilage. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 94 (pp. A12). Retrieved from http://gateway.webofknowledge.com/

    Protein signatures of the human osteoarthritic cartilage secretome (Conference Paper)

    Peffers, M. J., Beynon, R. J., & Clegg, P. D. (2013). Protein signatures of the human osteoarthritic cartilage secretome. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 94 (pp. A11-A12). Retrieved from http://gateway.webofknowledge.com/

    Transcriptomic signatures in cartilage ageing (Journal article)

    Peffers, M. J., Liu, X., & Clegg, P. D. (2013). Transcriptomic signatures in cartilage ageing. ARTHRITIS RESEARCH & THERAPY, 15(4). doi:10.1186/ar4278

    DOI: 10.1186/ar4278

    AGEING AND OSTEOARTHRITIS MARKERS IDENTIFIED BY MALDI IMAGING MASS SPECTROMETRY (Conference Paper)

    Peffers, M. J., Cillero-Pastor, B., Eijkel, G., Clegg, P. D., & Heeren, R. M. (2013). AGEING AND OSTEOARTHRITIS MARKERS IDENTIFIED BY MALDI IMAGING MASS SPECTROMETRY. In OSTEOARTHRITIS AND CARTILAGE Vol. 21 (pp. S63). doi:10.1016/j.joca.2013.02.140

    DOI: 10.1016/j.joca.2013.02.140

    TRANSCRIPTOMIC SIGNATURES IN CARTILAGE AGEING (Conference Paper)

    Peffers, M. J., Tew, S. R., & Clegg, P. D. (2013). TRANSCRIPTOMIC SIGNATURES IN CARTILAGE AGEING. In OSTEOARTHRITIS AND CARTILAGE Vol. 21 (pp. S9). doi:10.1016/j.joca.2013.02.040

    DOI: 10.1016/j.joca.2013.02.040

    Transcriptomic signatures in cartilage ageing (Journal article)

    Peffers, M., Liu, X., & Clegg, P. (2013). Transcriptomic signatures in cartilage ageing. Arthritis Research & Therapy, 15(4), R98. doi:10.1186/ar4278

    DOI: 10.1186/ar4278

    2012

    ABSOLUTE QUANTIFICATION OF CARTILAGE MATRIX PROTEINS (Conference Paper)

    Peffers, M. J., Beynon, R. J., Thornton, D. J., & Clegg, P. D. (2012). ABSOLUTE QUANTIFICATION OF CARTILAGE MATRIX PROTEINS. In RHEUMATOLOGY Vol. 51 (pp. 98). Retrieved from http://gateway.webofknowledge.com/

    PROTEOMIC CHARACTERISATION AND QUANTIFICATION OF AN IN-VITRO EARLY EQUINE OSTEOARTHRITIS MODEL (Conference Paper)

    Peffers, M. J., Beynon, R. J., Thornton, D., & Clegg, P. D. (2012). PROTEOMIC CHARACTERISATION AND QUANTIFICATION OF AN IN-VITRO EARLY EQUINE OSTEOARTHRITIS MODEL. In OSTEOARTHRITIS AND CARTILAGE Vol. 20 (pp. S261-S262). doi:10.1016/j.joca.2012.02.439

    DOI: 10.1016/j.joca.2012.02.439

    2011

    Absolute quantification of the equine early osteoarthritis secretome using QconCAT (Conference Paper)

    Peffers, M. J., Beynon, R. J., Thornton, D. J., & Clegg, P. D. (2011). Absolute quantification of the equine early osteoarthritis secretome using QconCAT. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 92 (pp. A20-A21). Retrieved from http://gateway.webofknowledge.com/

    Post-transcriptional gene regulation following exposure of osteoarthritic human articular chondrocytes to hyperosmotic conditions (Journal article)

    Tew, S. R., Vasieva, O., Peffers, M. J., & Clegg, P. D. (2011). Post-transcriptional gene regulation following exposure of osteoarthritic human articular chondrocytes to hyperosmotic conditions. OSTEOARTHRITIS AND CARTILAGE, 19(8), 1036-1046. doi:10.1016/j.joca.2011.04.015

    DOI: 10.1016/j.joca.2011.04.015

    Protein profiling of pathological cartilage (Conference Paper)

    Peffers, M. J., Beynon, R. J., Thornton, D. J., & Clegg, P. D. (2011). Protein profiling of pathological cartilage. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 92 (pp. A18-A19). Retrieved from http://gateway.webofknowledge.com/

    2010

    Regulation of SOX9 in normal and osteoarthritic equine articular chondrocytes by hyperosmotic loading (Journal article)

    Peffers, M. J., Milner, P. I., Tew, S. R., & Clegg, P. D. (2010). Regulation of SOX9 in normal and osteoarthritic equine articular chondrocytes by hyperosmotic loading. OSTEOARTHRITIS AND CARTILAGE, 18(11), 1502-1508. doi:10.1016/j.joca.2010.08.011

    DOI: 10.1016/j.joca.2010.08.011

    CYCLICAL HYPEROSMOLAR LOADING OF HUMAN ARTICULAR CHONDROCYTES INCREASES SOX9 GENE EXPRESSION AND P38 SIGNALLING IS REQUIRED (Conference Paper)

    Peffers, M. J., Clegg, P. D., Tew, S., & Milne, P. I. (2010). CYCLICAL HYPEROSMOLAR LOADING OF HUMAN ARTICULAR CHONDROCYTES INCREASES SOX9 GENE EXPRESSION AND P38 SIGNALLING IS REQUIRED. In OSTEOARTHRITIS AND CARTILAGE Vol. 18 (pp. S125). doi:10.1016/S1063-4584(10)60306-8

    DOI: 10.1016/S1063-4584(10)60306-8

    The MEK-ERK signalling pathway plays a role in SOX9 gene expression in human articular chondrocytes (Conference Paper)

    Peffers, M. J., Tew, S. R., Milner, P. I., & Clegg, P. D. (2010). The MEK-ERK signalling pathway plays a role in SOX9 gene expression in human articular chondrocytes. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 91 (pp. A38). Retrieved from http://gateway.webofknowledge.com/

    2009

    Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes (Journal article)

    Tew, S. R., Peffers, M. J., McKay, T. R., Lowe, E. T., Khan, W. S., Hardingham, T. E., & Clegg, P. D. (2009). Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 297(4), C898-C906. doi:10.1152/ajpcell.00571.2008

    DOI: 10.1152/ajpcell.00571.2008