Professor Malcolm Jackson BSc, PhD, DSc, FRCPath FTPS

Research Grants

Investigating mitochondrial dynamics and ER-mitochondrial communication in RPE in ageing and macular disease

MACULAR DISEASE SOCIETY (UK)

September 2021 - August 2024

Bench fees for Ufuk Ersoy / 201443759

TURKISH EMBASSY (LONDON)

February 2021 - January 2025

HDHL- Combining vitamin E-functionalized chocolate with physical exercise to reduce the risk of protein-energy malnutrition in aged people (CHOKO-AGE)

UK RESEARCH AND INNOVATION

April 2021 - April 2025

Close regulation of peroxiredoxin oxidation is essential for maintenance of muscle mass and function in the elderly.

MEDICAL RESEARCH COUNCIL

December 2021 - November 2024

University of Liverpool Translational Institutional Partnership (TRAP)

WELLCOME TRUST (UK)

February 2021 - February 2024

Mitochondria as a key regulator of muscle loss in microgravity and during ageing on earth (MicroAge II)

SCIENCE AND TECHNOLOGY FACILITIES COUNCIL

October 2020 - March 2021

Mitochondrial hydrogen peroxide as the mediator of skeletal muscle loss under microgravity and during ageing on earth

UK SPACE AGENCY (UK)

October 2021 - September 2022

PROSPER

RESEARCH ENGLAND (UK)

April 2021 - September 2023

Aquaporins: A hole in our understanding of ROS signalling

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

September 2019 - November 2022

Microgravity as a model for accelerated skeletal muscle ageing

UK SPACE AGENCY (UK)

November 2018 - May 2022

CIMA Centre Renewal

MEDICAL RESEARCH COUNCIL, VERSUS ARTHRITIS (UK)

June 2017 - May 2028

Neuromuscular redox homeostasis in mice lacking SOD1 and aging wild type mice

NATIONAL INSTITUTES OF HEALTH (USA)

September 2016 - April 2022

Disruption of redox relays in the age-related failure of muscle responses to contractile activity

MEDICAL RESEARCH COUNCIL

March 2017 - September 2021

2014 allocation - Wellcome ISSF non clinical fellowships

WELLCOME TRUST (UK)

May 2015 - October 2018

Gene editing of Age related Macular Degeneration risk factor in retinal pigment epithelial cells: could modulation of proteolytic control lead to new therapeutic interventions for Age related Macular Degeneration?

MACULAR DISEASE SOCIETY (UK)

November 2016 - November 2019

Microgravity as a model for accelerated skeletal muscle ageing

UK SPACE AGENCY (UK)

October 2017 - April 2018

Paraneoplastic neurological syndromes (PNS). Strengthening the European Network.

EUROPEAN COMMISSION

January 2006 - June 2009

Denervation of small numbers of fibres during ageing leads to dysregulation of ROS and functional changes in whole skeletal muscles

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

April 2013 - March 2016

Site-specific failure of redox homeostasis as a cause of age-related loss of skeletal muscle mass and function

MEDICAL RESEARCH COUNCIL

May 2008 - May 2011

University of Liverpool Institutional Discipline Bridging.

MEDICAL RESEARCH COUNCIL

October 2003 - October 2006

CIMA centre capital equipment

MEDICAL RESEARCH COUNCIL

April 2014 - May 2017

The role of copper and zinc in osteoporosis.

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

February 1997 - July 2001

Ageing-Related Skeletal Muscle Weakness: Mechanisms of Prevention by Stress Proteins.

RESEARCH INTO AGEING

October 2001 - September 2006

Molecular mechanisms of preservation of muscle with age by HSP70.

EUROPEAN COMMISSION

August 2002 - July 2004

Examination of the effect of antioxidant supplementation on the ability of cells from the elderly to respond to stress.

ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

August 2001 - July 2002

European research on functional effects of dietary antioxydants (EUROFEDA).

EUROPEAN COMMISSION

January 2000 - December 2002

Centre of Excellence in musculoskeletal ageing research (MRC CIMA)

MEDICAL RESEARCH COUNCIL

June 2012 - December 2017

Value in People Award 2005.

WELLCOME TRUST (UK)

October 2005 - September 2009

Correction of marginal dietary selenium intake and cancer risk in the UK.

WORLD CANCER RESEARCH FUND (UK)

October 2002 - April 2006

Capacity building award in integrative mammalian biology

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

January 2007 - October 2015

Insulin resistance mediates age-related loss of muscle mass and function

RESEARCH INTO AGEING

February 2007 - February 2010

Modulation of aberrant mitochondrial and cytokine production in muscles of patients with CFS by polyphenols

MEDICAL RESEARCH COUNCIL, THE ME ASSOCIATION (UK)

September 2012 - April 2016

Functional markers of selenium status in man (AN0545).

MINISTRY AGRIC/FISHERIES/FOOD

April 1998 - March 2001

Angiotensin 11 blockade in the proximal renal tubular cell : mechanisms of injury, metabolism and renoprotection.

MERSEY KIDNEY FIRST (UK)

January 2001 - December 2007

YEAR 1 (part2) Wellcome Trust ISSF Non-Clinical Fellowships

WELLCOME TRUST (UK)

October 2012 - March 2023

Liverpool Imaging Partnership: Molecular physiology and drug response

MEDICAL RESEARCH COUNCIL

February 2013 - February 2017

Hydrogen peroxide generation regulates proximal tubular cell responses to excessive protein exposure.

MERSEY KIDNEY FIRST (UK)

January 2006 - December 2008

Free radical generation by skeletal muscle: signals for adaptation to contractile activity?

WELLCOME TRUST (UK)

February 2001 - February 2004

Selenium, immune status and viral handling.

FOOD STANDARDS AGENCY (UK)

January 2005 - September 2010

New non-angiotensinII type 1 receptor-mediated mechanisms of inducing oxidative stress and modulating stress-related gene expression in renal proximal tubular cells implications for transplant patients with chronic allograft nephropathy.

ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

March 2007 - May 2007

The role of heat shock proteins in ageing-related loss of muscle function.

RESEARCH INTO AGEING

April 1998 - April 2001

A PCR based technique for cloning the sites of oxidative DNA damage and measuring the 'in vivo' protective effects of dietary antioxidants.

MINISTRY AGRIC/FISHERIES/FOOD

April 1998 - May 2001

Liverpool BioAFM: an integrated optical and atomic force microscope for research across the life sciences

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

January 2015 - January 2016

Glutathione Metabolism in Muscle and Kidney in Severe Systemic Inflammation.

WELLCOME TRUST (UK)

August 1998 - September 2001

Admin. and Secretarial Support to the NWCRF Sci.Comte.

NORTH WEST CANCER RESEARCH FUND

January 1990 - December 2019

Protein overload, oxidative metabolism and the proximal tubules.

ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

April 2004 - November 2007

Extracellular Reactive Oxygen Species as Propagators of Tissue Ageing.

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

July 2002 - February 2006

Generation of reactive oxygen species by skeletal muscle mitochondria as a target for interventions to prevent age-related loss of muscle mass and function

MEDICAL RESEARCH COUNCIL

September 2011 - November 2013

Cystatin C in age-related macular degeneration: mechanism of action and consequences on cellular processes.

RESEARCH INTO AGEING

October 2010 - December 2013

Cross-Linked Actin Networks (CLANs). Are they a morphological fingerprint of trabecular meshwork cell malfunction in glaucoma that may be targeted as a new treatment direction?

THE GUIDE DOGS FOR THE BLIND ASSOCIATION (UK)

April 2006 - March 2009

Translational research into Frailty for the benefit of Older People

THE DOWAGER COUNTESS ELEANOR PEEL TRUST (UK)

February 2009 - April 2012

Novel renal proximal tubular pathways of injury: Angiotensin II induces fibrosis via Angiiotensin II receptors other than type I.

MERSEY KIDNEY FIRST (UK)

May 2007 - December 2010

Assessment of individual variability in functional responses to selenium.

FOOD STANDARDS AGENCY (UK)

October 2001 - March 2003

Fluorescence Light Sheet Microscopy for Live 3D and 4D imaging

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

January 2014 - June 2014

YEAR 1 Wellcome Trust ISSF Non-Clinical Fellowships

WELLCOME TRUST (UK)

October 2011 - May 2018

Ageing-related muscle dysfunction: A failure of adaptation to oxidative stress?

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

November 1998 - November 2001

Wellcome VIP - Pearson

WELLCOME TRUST (UK)

May 2011 - August 2011

A failure of neuroprotective redox signalling from skeletal muscle to motor neurons leads to loss of motor units with ageing

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

September 2011 - August 2014

Dietary polyphenols as modulators of redox signalling pathways to reduce chronio inflammation in the elderly

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

April 2011 - January 2015

The effects of dietary selenium supplementation on depression in older subjects.

ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

November 2003 - July 2006

Nitric oxide-superoxide interactions in the regulation of skeletal muscle adaptations and damage following contractile activity.

WELLCOME TRUST (UK)

January 2004 - October 2009

Motor unit remodelling contributes to the age-related loss of skeletal muscle fibres

MEDICAL RESEARCH COUNCIL

June 2015 - June 2018

Wellcome VIP Award - Victoria Kearns

WELLCOME TRUST (UK)

July 2011 - September 2011

Research Collaborations