About our research

Loss of skeletal muscle mass and function during ageing (sometimes called sarcopenia) is a major contributor to increasing frailty in older people and plays a key role in loss of independence and poor quality of life in older individuals. Much of the research undertaken by the muscle research group is focussed on understanding the mechanisms that contribute to age-related loss of muscle and to identifying potential approaches to prevention or reversal of this loss.

The scope of the work undertaken ranges from novel cell and tissue culture approaches to studies of mouse models and investigations of ageing and sarcopenia in human subjects.

Loss of muscle mass and function is also associated with many chronic disorders and the key processes studied by this group are also relevant to understanding muscle loss and weakness in these patients.

These include some conditions for which the prevalence is increased during ageing, such as chronic obstructive pulmonary disease (COPD) and a range of other disorders as diverse as motor neurone disease and Chronic Fatigue Syndrome (ME/CFS). Members of the group work closely with clinical colleagues in studying these patients.