Dr Simon Abrams PhD

Personal Statement

I am a basic scientist with a research interest in Haemostasis & Thrombosis. Our groups main research focus utilizes strong clinical links within the NHS to improve patient care in critically ill patients, particularly in intensive care units (ICU). Our current research utilizes in vitro and in vivo models, along side clinical samples to comprehensively undertake translational research. Our main area of research is understanding the underlying pathological mechanisms which drive poor outcomes in ICU patients, with the aim of developing new diagnostic & prognostic tests, along with therapeutic interventions. Over the past decade, we have investigated the pathological role of circulating histones and neutrophil extracellular traps (NETs) in critical illness, particularly in promoting coagulation activation, inflammation and multiple organ dysfunction. Disease areas of interest include sepsis, trauma and severe acute pancreatitis.