2022
Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., de Silva, T. I., Siggins, M. K., . . . Young, P. (2022). Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. Open Forum Infectious Diseases, 9(5). doi:10.1093/ofid/ofac179DOI: 10.1093/ofid/ofac179
Alsabani, M., Abrams, S. T., Cheng, Z., Morton, B., Lane, S., Alosaimi, S., . . . Toh, C. -H. (2022). Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis. British Journal of Anaesthesia, 128(2), 283-293. doi:10.1016/j.bja.2021.10.039DOI: 10.1016/j.bja.2021.10.039
2021
Shaw, R. J., Abrams, S. T., Austin, J., Taylor, J. M., Lane, S., Dutt, T., . . . Toh, C. -H. (2021). Circulating histones play a central role in COVID-19-associated coagulopathy and mortality. HAEMATOLOGICA, 106(9), 2493-2498. doi:10.3324/haematol.2021.278492DOI: 10.3324/haematol.2021.278492
Shaw, R. J., Bradbury, C., Abrams, S. T., Wang, G., & Toh, C. -H. (2021). COVID-19 and immunothrombosis: emerging understanding and clinical management. BRITISH JOURNAL OF HAEMATOLOGY, 194(3), 518-529. doi:10.1111/bjh.17664DOI: 10.1111/bjh.17664
Thwaites, R. S., Sanchez Sevilla Uruchurtu, A., Siggins, M. K., Liew, F., Russell, C. D., Moore, S. C., . . . ISARIC4C investigators. (2021). Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.. Science Immunology, 6(57). doi:10.1126/sciimmunol.abg9873DOI: 10.1126/sciimmunol.abg9873
2020
Wang, Z., Cheng, Z. -X., Abrams, S. T., Lin, Z. -Q., Yates, E. D., Yu, Q., . . . Wang, G. -Z. (2020). Extracellular histones stimulate collagen expression <i>in vitro</i> and promote liver fibrogenesis in a mouse model <i>via </i>the TLR4-MyD88 signaling pathway. WORLD JOURNAL OF GASTROENTEROLOGY, 26(47), 7513-7527. doi:10.3748/wjg.v26.i47.7513DOI: 10.3748/wjg.v26.i47.7513
The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development (Journal article)
Cheng, Z., Abrams, S. T., Austin, J., Toh, J., Wang, S. S., Wang, Z., . . . Wang, G. (2020). The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development. MEDIATORS OF INFLAMMATION, 2020. doi:10.1155/2020/7418342DOI: 10.1155/2020/7418342
Cheng, Z., Abrams, S. T., Toh, J., Wang, S. S., Wang, Z., Yu, Q., . . . Wang, G. (2020). The Critical Roles and Mechanisms of Immune Cell Death in Sepsis. FRONTIERS IN IMMUNOLOGY, 11. doi:10.3389/fimmu.2020.01918DOI: 10.3389/fimmu.2020.01918
Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation (Journal article)
Abrams, S. T., Su, D., Sahraoui, Y., Lin, Z., Cheng, Z., Nesbitt, K., . . . Toh, C. -H. (2021). Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation. BLOOD, 137(1), 103-114. doi:10.1182/blood.2019002973DOI: 10.1182/blood.2019002973
Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria (Journal article)
Moxon, C. A., Alhamdi, Y., Storm, J., Toh, J. M. H., McGuinness, D., Ko, J. Y., . . . Toh, C. (n.d.). Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria. Blood Advances, 4(13), 2851-2864. doi:10.1182/bloodadvances.2019001258DOI: 10.1182/bloodadvances.2019001258
Cheng, Z., Abrams, S. T., Toh, J., Wang, S. S., Downey, C., Ge, X., . . . Toh, C. -H. (2020). Complexes between C-Reactive Protein and Very Low Density Lipoprotein Delay Bacterial Clearance in Sepsis. Journal of Immunology, 204(10), 2712-2721. doi:10.4049/jimmunol.1900962DOI: 10.4049/jimmunol.1900962
Moxon, C., Alhamdi, Y., Storm, J., Toh, J., Ko, J. Y., Murphy, G., . . . Toh, C. -H. (2020). Parasite histones mediate blood-brain barrier disruption in cerebral malaria.. Clinical medicine (London, England), 20(Suppl 2), s96-s97. doi:10.7861/clinmed.20-2-s96DOI: 10.7861/clinmed.20-2-s96
Abrams, S., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2020). A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit.. Clinical medicine (London, England), 20(Suppl 2), s114-s115. doi:10.7861/clinmed.20-2-s114DOI: 10.7861/clinmed.20-2-s114
2019
Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Lane, S., Welters, I. D., . . . Toh, C. -H. (2019). A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients. American journal of respiratory and critical care medicine, 200(07), 869-880. doi:10.1164/rccm.201811-2111ocDOI: 10.1164/rccm.201811-2111oc
Cheng, Z., Abrams, S. T., Alhamdi, Y., Toh, J., Yu, W., Wang, G., & Toh, C. -H. (2019). Circulating Histones Are Major Mediators of Multiple Organ Dysfunction Syndrome in Acute Critical Illnesses.. Critical care medicine, 47(8), e677-e684. doi:10.1097/ccm.0000000000003839DOI: 10.1097/ccm.0000000000003839
Disseminated intravascular coagulation - what can we do? (Journal article)
Toh, C. -H., Toh, J. M. H., & Abrams, S. T. (2019). Disseminated intravascular coagulation - what can we do?. HEMASPHERE, 3, 92-94. doi:10.1097/HS9.0000000000000232DOI: 10.1097/HS9.0000000000000232
Welters, I. D. M., Waite, A., Alhamdi, Y., Abrams, S., Toh, C., Iqbal, R., & Venugopal, N. (2019). Sepsis-associated coagulopathy and the association of platelet count with mortality. In Critical Care Vol. 23, Suppl 2 (pp. 146). Brussels: Springer Nature.
2018
Qaddoori, Y., Abrams, S. T., Mould, P., Alhamdi, Y., Christmas, S. E., Wang, G., & Toh, C. -H. (2018). Extracellular Histones Inhibit Complement Activation through Interacting with Complement Component 4. JOURNAL OF IMMUNOLOGY, 200(12), 4125-4133. doi:10.4049/jimmunol.1700779DOI: 10.4049/jimmunol.1700779
2017
Szatmary, P., Liu, T., Abrams, S. T., Voronina, S., Wen, L., Chvanov, M., . . . Sutton, R. (2017). Systemic histone release disrupts plasmalemma and contributes to necrosis in acute pancreatitis. PANCREATOLOGY, 17(6), 884-892. doi:10.1016/j.pan.2017.10.002DOI: 10.1016/j.pan.2017.10.002
Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Alhamdi, Y., Lin, Z., . . . Toh, C. H. (2017). Accuracy of circulating histones in predicting persistent organ failure and mortality in patients with acute pancreatitis. BRITISH JOURNAL OF SURGERY, 104(9), 1215-1225. doi:10.1002/bjs.10538DOI: 10.1002/bjs.10538
Schoergenhofer, C., Schwameis, M., Wohlfarth, P., Brostjan, C., Abrams, S. T., Toh, C. -H., & Jilma, B. (2017). Granulocyte colony-stimulating factor (G-CSF) increases histone-complexed DNA plasma levels in healthy volunteers. CLINICAL AND EXPERIMENTAL MEDICINE, 17(2), 243-249. doi:10.1007/s10238-016-0413-6DOI: 10.1007/s10238-016-0413-6
2016
Toh, C. -H., Alhamdi, Y., & Abrams, S. T. (2016). Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation. ANNALS OF LABORATORY MEDICINE, 36(6), 505-512. doi:10.3343/alm.2016.36.6.505DOI: 10.3343/alm.2016.36.6.505
Alhamdi, Y., Zi, M., Abrams, S., Liu, T., Su, D., Welters, I., . . . Toh, C. -H. (2016). Circulating Histone Concentrations Differentially Affect the Predominance of Left or Right Ventricular Dysfunction in Critical Illness. Critical Care Medicine, 44(05), e278-e288. doi:10.1097/CCM.0000000000001413DOI: 10.1097/CCM.0000000000001413
Iqbal, R., Alhamdi, Y., Venugopal, N., Abrams, S., Downey, C., Toh, C. H., & Welters, I. D. M. (2016). Disseminated intravascular coagulation (dic) is underdiagnosed in critically ill patients: do we need d-dimer measurements?. In Critical Care Vol. 20 (pp. P127). Brussels: BioMed Central.
Alhamdi, Y., Abrams, S., Lane, S., Wang, G., & Toh, C. -H. (2016). Histone-Associated Thrombocytopenia in Patients Who Are Critically Ill. JAMA: Journal of the American Medical Association, 315(8), 817-819. doi:10.1001/jama.2016.0136DOI: 10.1001/jama.2016.0136
2015
Alhamdi, Y., Abrams, S. T., Cheng, Z., Jing, S., Su, D., Liu, Z., . . . Toh,, C. -H. (2015). Circulating histones are major mediators of cardiac injury in patients with sepsis. Critical Care Medicine, 43(10), 2094-2103. doi:10.1097/CCM.0000000000001162DOI: 10.1097/CCM.0000000000001162
Alhamdi, Y., Neill, D., Abrams, S., Malak, H., Yahya, R., Barrett-Jolley, R., . . . Toh, C. -H. (2015). Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection. PLoS Pathogens, 11(5). doi:10.1371/journal.ppat.1004836DOI: 10.1371/journal.ppat.1004836
2013
Human CRP Defends against the Toxicity of Circulating Histones (Journal article)
Abrams, S. T., Zhang, N., Dart, C., Wang, S. S., Thachil, J., Guan, Y., . . . Toh, C. -H. (2013). Human CRP Defends against the Toxicity of Circulating Histones. JOURNAL OF IMMUNOLOGY, 191(5), 2495-2502. doi:10.4049/jimmunol.1203181DOI: 10.4049/jimmunol.1203181
Abrams, S. T., Zhang, N., Manson, J., Liu, T., Dart, C., Baluwa, F., . . . Toh, C. -H. (2013). Circulating Histones Are Mediators of Trauma-associated Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 187(2), 160-169. doi:10.1164/rccm.201206-1037OCDOI: 10.1164/rccm.201206-1037OC
2010
Vascular endothelial growth factor stimulates protein kinase CβII expression in chronic lymphocytic leukemia cells (Journal article)
Abrams, S. T., Brown, B. R. B., Zuzel, M., & Slupsky, J. R. (2010). Vascular endothelial growth factor stimulates protein kinase CβII expression in chronic lymphocytic leukemia cells. BLOOD, 115(22), 4447-4454. doi:10.1182/blood-2009-06-229872DOI: 10.1182/blood-2009-06-229872
2007
B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CβII (Journal article)
Abrams, S. T., Lakum, T., Lin, K., Jones, G. M., Treweeke, A. T., Farahani, M., . . . Slupsky, J. R. (2007). B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CβII. BLOOD, 109(3), 1193-1201. doi:10.1182/blood-2006-03-012021DOI: 10.1182/blood-2006-03-012021
