Photo of Dr Maya Wardeh

Dr Maya Wardeh MEng, PhD

NPIF Rsearch Fellow Livestock & One Health

Research

Big Data approaches to identifying potential sources of emerging pathogens

Example of shared-pathogens ecological multi-host networks
Example of shared-pathogens ecological multi-host networks

Emerging infectious diseases continue to pose major threats to humans, animals and plants. Recent years have seen significant outbreaks of several emerging diseases, ranging from the well-known (Ebola and Olive quick decline syndrome), to the previously little known (Zika), to the entirely novel (Schmallenberg), to name but a few. It is well established that the ability of a pathogen to infect multiple hosts, particularly hosts in different taxonomic orders or wildlife, is a risk factor for emergence in human and livestock pathogens. Emerging wild-life diseases have also been linked to 'spill-overs' from humans or domesticated animals. Despite the importance of cross-species disease transmission, there has been relatively little attention paid to which species are the most important sources cross communities (e.g., zoonotic, wild-life to domestic, plants to other kingdoms), which are the most prolific vectors, how those species acquired the pathogens, and by what means the diseases entered new species or populations. A major reason for this limited understanding is the lack of comprehensive data on the pathogens in animal and plant populations and, in most cases, poorly documented information on how they are transmitted, including to humans.

Currently I am investigating the factors which lead to emergence of pathogens, asking the following questions:
1. What are the characteristics of the networks that connect species via shared pathogens? How central are humans and their domesticated animals and crops in these networks and which other species are each of those communities most closely connected to?
2. What is the role of different pathogen transmission routes on the nature of these networks? Are the potential species-to-species transmission pathways different for direct, food-borne, water-borne and vector-borne pathogens?
3. What factors determine the host ranges of pathogens? Are host species more likely to become exposed to pathogens that infect a wide range of species? From species that are closer to them genetically? Or from those species with which they often interact?
4. What are we missing? Given the networks, transmission routes and host ranges, what is the risk associated with each pathogen emerging in new species? What are the pathogens that can be prioritised as more-likely to emerge in the future?

Big Data Epidemiology - The Enhanced Infectious Diseases Database (EID2)

Network of shared major vector-borne pathogens between hosts and vectors
Network of shared major vector-borne pathogens between hosts and vectors

EID2 database

Recent years have seen a massive increase in open-access scientific output, both in terms of publications and genomic sequences. For instance, last year alone saw the publication of over 16% of the total number of papers indexed by PubMed, and approximately 20% of the total number of sequences uploaded to Genbank. The sheer volume, not to mention other complexities, of scientific output exceeds the ability of researchers, using traditional methods, to make effective use and assessment of all available findings. The Enhanced Infectious Diseases Database system (EID2) utilises data and text mining tools, with minimal expert input, in order to answer a range of questions such as: 1) What is the host-range of given pathogen/microbe ? 2) What are all the pathogens/microbes of given host? 3) What are all the vector species of certain pathogen? And which hosts do they transmit this pathogen to? 4) What is the geographical range of an organism (host, pathogen or vector)?
In order to provide answers to these questions the EID2 system comprises the following components:
1. Data repositories: EID2 maintains a number of complex data repositories and mapping dictionaries to facilitate interaction discovery and named entity recognition, including: 1) Organisms and their taxonomic lineage relationships (over 1 million organisms to date). 2) Alternative names (e.g. common names, common misspelling, breeds and acronyms), inclusion (AND) and exclusion (NOT) terms for the organisms. 3) Geographical names and hierarchies, including countries, administrative divisions, major cities and natural features. 4) Climate (e.g., temperature and rainfall) and demographic (human and livestock) data for the whole world.
2. Data acquisition layer: EID2 continually retrieves and classifies evidence from two sources: NCBI Nucleotide Sequences database; and PubMed (and soon to include Scopus as a third). Each piece of evidence is then linked to the organisms and geographical location. Sequences are often linked to one “cargo” organism which is either microbe (pathogen) or arthropod vector, one host organism and one location. Publications however are often linked to multiple organisms and locations. One powerful utilisation of EID2 is our ability to quickly extract and filter evidence based on the number of hosts/pathogens/vectors species or locations it mentions. This facilitates other process of EID2, and it enables us to conduct research in other avenues (such as transmission route discovery and co-infection interactions discovery).
3. Interactions discovery pipeline: EID2 extracts three types of interactions from its evidence bases: organism-organism interactions, organism-location interactions and organism-organism-location interactions. (Wardeh et al) provides detailed explanation of the process.
4. EID2 Portal: publically accessible at: https://eid2.liverpool.ac.uk/. The portal enables users to browse through EID2 data, lookup interactions for one or more organisms, and produce tailored maps.

Research Grants

Big data approaches to identifying potential sources of emerging pathogens in humans, domesticated animals and crops: NPIF Fellowship for Maya Wardeh

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC), UK RESEARCH AND INNOVATION (UKRI) (UK)

November 2017 - September 2021

Big Data approaches to host-pathogen mapping: EID2 - an open-access, taxonomically- and spatially-referenced database of pathogens and their hosts

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

October 2016 - March 2018