Prof Julian Hiscox BSc PhD

Chair in Infection and Global Health Infection Biology

    Publications

    2019

    Antibody correlates of protection for Ebola virus infection: Effects of mutations within the viral glycoprotein on immune escape. (Thesis / Dissertation)

    Steeds, K. (2019, January 28). Antibody correlates of protection for Ebola virus infection: Effects of mutations within the viral glycoprotein on immune escape..

    Experimental infection of rabbit with swine-derived hepatitis E virus genotype 4 (Journal article)

    Liu, B., Chen, Y., Sun, Y., Nan, Y., Li, H., Du, T., . . . Zhou, E. -M. (2019). Experimental infection of rabbit with swine-derived hepatitis E virus genotype 4. VETERINARY MICROBIOLOGY, 229, 168-175. doi:10.1016/j.vetmic.2019.01.001

    DOI: 10.1016/j.vetmic.2019.01.001

    Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak (Journal article)

    Kafetzopoulou, L. E., Pullan, S. T., Lemey, P., Suchard, M. A., Ehichioya, D. U., Pahlmann, M., . . . Duraffour, S. (2019). Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak. SCIENCE, 363(6422), 74-+. doi:10.1126/science.aau9343

    DOI: 10.1126/science.aau9343

    Using label-free proteomics to elucidate factors involved in the human response to orthohantavirus infection (Thesis / Dissertation)

    Bar-Yaacov, S. B. (2019, January 19). Using label-free proteomics to elucidate factors involved in the human response to orthohantavirus infection.

    2018

    Assessment of metagenomic Nanopore and Illumina sequencing for recovering whole genome sequences of chikungunya and dengue viruses directly from clinical samples (Journal article)

    Kafetzopoulou, L. E., Efthymiadis, K., Lewandowski, K., Crook, A., Carter, D., Osborne, J., . . . Pullan, S. T. (2018). Assessment of metagenomic Nanopore and Illumina sequencing for recovering whole genome sequences of chikungunya and dengue viruses directly from clinical samples. EUROSURVEILLANCE, 23(50), 18-30. doi:10.2807/1560-7917.ES.2018.23.50.1800228

    DOI: 10.2807/1560-7917.ES.2018.23.50.1800228

    Characterising the host response to the emerging Ebola virus, Makona variant from West Africa (Thesis / Dissertation)

    Bosworth, A. J. (2018, November 6). Characterising the host response to the emerging Ebola virus, Makona variant from West Africa.

    Characterization of Three Novel Linear Neutralizing B-Cell Epitopes in the Capsid Protein of Swine Hepatitis E Virus (Journal article)

    Chen, Y., Liu, B., Sun, Y., Li, H., Du, T., Nan, Y., . . . Zhao, Q. (2018). Characterization of Three Novel Linear Neutralizing B-Cell Epitopes in the Capsid Protein of Swine Hepatitis E Virus. JOURNAL OF VIROLOGY, 92(13). doi:10.1128/JVI.00251-18

    DOI: 10.1128/JVI.00251-18

    Cross-species infection of mice by rabbit hepatitis E virus (Journal article)

    Sun, Y., Lu, Q., Liu, B., Sheng, Y., Du, T., Hiscox, J. A., . . . Zhao, Q. (2018). Cross-species infection of mice by rabbit hepatitis E virus. VETERINARY MICROBIOLOGY, 225, 48-52. doi:10.1016/j.vetmic.2018.09.015

    DOI: 10.1016/j.vetmic.2018.09.015

    Evaluating models of Influenza A virus Infection (Thesis / Dissertation)

    Zekeng, E. (2018, December 4). Evaluating models of Influenza A virusInfection.

    Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathway (Journal article)

    Song, L., Han, X., Jia, C., Zhang, X., Jiao, Y., Du, T., . . . Mu, Y. (2018). Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathway. VIROLOGY JOURNAL, 15. doi:10.1186/s12985-018-1081-9

    DOI: 10.1186/s12985-018-1081-9

    Recombinant MYH9 protein C-terminal domain blocks porcine reproductive and respiratory syndrome virus internalization by direct interaction with viral glycoprotein 5 (Journal article)

    Li, L., Xue, B., Sun, W., Gu, G., Hou, G., Zhang, L., . . . Zhou, E. -M. (2018). Recombinant MYH9 protein C-terminal domain blocks porcine reproductive and respiratory syndrome virus internalization by direct interaction with viral glycoprotein 5. ANTIVIRAL RESEARCH, 156, 10-20. doi:10.1016/j.antiviral.2018.06.001

    DOI: 10.1016/j.antiviral.2018.06.001

    T-Cell Receptor Diversity and the Control of T-Cell Homeostasis Mark Ebola Virus Disease Survival in Humans (Journal article)

    Speranza, E., Ruibal, P., Port, J. R., Feng, F., Burkhardt, L., Grundhoff, A., . . . Munoz-Fontela, C. (2018). T-Cell Receptor Diversity and the Control of T-Cell Homeostasis Mark Ebola Virus Disease Survival in Humans. JOURNAL OF INFECTIOUS DISEASES, 218, S508-S518. doi:10.1093/infdis/jiy352

    DOI: 10.1093/infdis/jiy352

    The Epidemiology and Surveillance of Culicoides-borne Diseases of Ruminants in the UK (Thesis / Dissertation)

    Stokes, J. E. (2018, March 5). The Epidemiology and Surveillance of Culicoides-borne Diseases of Ruminants in the UK.

    Viperin Poisons Viral Replication (Journal article)

    Ng, L. F. P., & Hiscox, J. A. (2018). Viperin Poisons Viral Replication. CELL HOST & MICROBE, 24(2), 181-183. doi:10.1016/j.chom.2018.07.014

    DOI: 10.1016/j.chom.2018.07.014

    Zika Virus Infection Preferentially Counterbalances Human Peripheral Monocyte and/or NK Cell Activity (Journal article)

    Lum, F. -M., Lee, D., Chua, T. -K., Tan, J. J. L., Lee, C. Y. P., Liu, X., . . . Ng, L. F. P. (2018). Zika Virus Infection Preferentially Counterbalances Human Peripheral Monocyte and/or NK Cell Activity. MSPHERE, 3(2). doi:10.1128/mSphereDirect.00120-18

    DOI: 10.1128/mSphereDirect.00120-18

    2017

    A comparison of host gene expression signatures associated with infection in vitro by the Makona and Ecran (Mayinga) variants of Ebola virus (Journal article)

    Bosworth, A., Dowall, S. D., Garcia-Dorival, I., Rickett, N. Y., Bruce, C. B., Matthews, D. A., . . . Hiscox, J. A. (2017). A comparison of host gene expression signatures associated with infection in vitro by the Makona and Ecran (Mayinga) variants of Ebola virus. SCIENTIFIC REPORTS, 7. doi:10.1038/srep43144

    DOI: 10.1038/srep43144

    Deep Sequencing of RNA from Blood and Oral Swab Samples Reveals the Presence of Nucleic Acid from a Number of Pathogens in Patients with Acute Ebola Virus Disease and Is Consistent with Bacterial Translocation across the Gut (Journal article)

    Carroll, M. W., Haldenby, S., Rickett, N. Y., Palyi, B., Garcia-Dorival, I., Liu, X., . . . Hiscox, J. A. (2017). Deep Sequencing of RNA from Blood and Oral Swab Samples Reveals the Presence of Nucleic Acid from a Number of Pathogens in Patients with Acute Ebola Virus Disease and Is Consistent with Bacterial Translocation across the Gut. MSPHERE, 2(4). doi:10.1128/mSphereDirect.00325-17

    DOI: 10.1128/mSphereDirect.00325-17

    Deep sequencing of RNA from blood and oral swab samples reveals the presence of nucleic acid from a number of pathogens in patients with acute Ebola virus disease and is consistent with bacterial translocation across the gut (Journal article)

    Carroll, M. W., Haldenby, S., Rickett, N. Y., Pályi, B., Garcia-Dorival, I., Liu, X., . . . Hiscox, J. A. (2017). Deep sequencing of RNA from blood and oral swab samples reveals the presence of nucleic acid from a number of pathogens in patients with acute Ebola virus disease and is consistent with bacterial translocation across the gut. mSphere, 2(4). doi:10.1128/mSphereDirect.00325-17

    DOI: 10.1128/mSphereDirect.00325-17

    Examining the Pathogenesis of Enterovirus 71 Using Human Cellular Models (Thesis / Dissertation)

    Cox, J. A. (2017, October 31). Examining the Pathogenesis of Enterovirus 71 Using Human Cellular Models.

    Heme oxygenase-1 metabolite biliverdin, not iron, inhibits porcine reproductive and respiratory syndrome virus replication (Journal article)

    Zhang, A., Duan, H., Li, N., Zhao, L., Pu, F., Huang, B., . . . Xiao, S. (2017). Heme oxygenase-1 metabolite biliverdin, not iron, inhibits porcine reproductive and respiratory syndrome virus replication. FREE RADICAL BIOLOGY AND MEDICINE, 102, 149-161. doi:10.1016/j.freeradbiomed.2016.11.044

    DOI: 10.1016/j.freeradbiomed.2016.11.044

    Immunopathogenesis and Virus-Host Interactions of Enterovirus 71 in Patients with Hand, Foot and Mouth Disease (Journal article)

    Cox, J. A., Hiscox, J. A., Solomon, T., Ooi, M. -H., & Ng, L. F. P. (2017). Immunopathogenesis and Virus-Host Interactions of Enterovirus 71 in Patients with Hand, Foot and Mouth Disease. FRONTIERS IN MICROBIOLOGY, 8. doi:10.3389/fmicb.2017.02249

    DOI: 10.3389/fmicb.2017.02249

    Rabbit hepatitis E virus is an opportunistic pathogen in specific-pathogen-free rabbits with the capability of cross-species transmission (Journal article)

    Liu, B., Sun, Y., Du, T., Chen, Y., Wang, X., Huan, B., . . . Zhao, Q. (2017). Rabbit hepatitis E virus is an opportunistic pathogen in specific-pathogen-free rabbits with the capability of cross-species transmission. VETERINARY MICROBIOLOGY, 201, 72-77. doi:10.1016/j.vetmic.2016.10.029

    DOI: 10.1016/j.vetmic.2016.10.029

    The role of infectious bronchitis virus accessory proteins 3a, 3b and 4b (Thesis / Dissertation)

    Hall, R. H. (2017, September 30). The role of infectious bronchitis virus accessory proteins 3a, 3b and 4b.

    Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus (Journal article)

    Liu, X., Speranza, E., Munoz-Fontela, C., Haldenby, S., Rickett, N. Y., Garcia-Dorival, I., . . . Hiscox, J. A. (2017). Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus. GENOME BIOLOGY, 18. doi:10.1186/s13059-016-1137-3

    DOI: 10.1186/s13059-016-1137-3

    Virus genomes reveal factors that spread and sustained the Ebola epidemic (Journal article)

    Dudas, G., Carvalho, L. M., Bedford, T., Tatem, A. J., Baele, G., Faria, N. R., . . . Rambaut, A. (2017). Virus genomes reveal factors that spread and sustained the Ebola epidemic. NATURE, 544(7650), 309-+. doi:10.1038/nature22040

    DOI: 10.1038/nature22040

    2016

    Antiviral Screening of Multiple Compounds against Ebola Virus (Journal article)

    Dowall, S. D., Bewley, K., Watson, R. J., Vasan, S. S., Ghosh, C., Konai, M. M., . . . Carroll, M. W. (2016). Antiviral Screening of Multiple Compounds against Ebola Virus. VIRUSES-BASEL, 8(11). doi:10.3390/v8110277

    DOI: 10.3390/v8110277

    Characterization of the Interactome of the Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 2 Reveals the Hyper Variable Region as a Binding Platform for Association with 14-3-3 Proteins (Journal article)

    Xiao, Y., Wu, W., Gao, J., Smith, N., Burkard, C., Xia, D., . . . Hiscox, J. A. (2016). Characterization of the Interactome of the Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 2 Reveals the Hyper Variable Region as a Binding Platform for Association with 14-3-3 Proteins. JOURNAL OF PROTEOME RESEARCH, 15(5), 1388-1401. doi:10.1021/acs.jproteome.5b00396

    DOI: 10.1021/acs.jproteome.5b00396

    Determination of the interactome of non-structural protein12 from highly pathogenic porcine reproductive and respiratory syndrome virus with host cellular proteins using high throughput proteomics and identification of HSP70 as a cellular factor for virus replication (Journal article)

    Dong, S., Liu, L., Wu, W., Armstrong, S. D., Xia, D., Nan, H., . . . Chen, H. (2016). Determination of the interactome of non-structural protein12 from highly pathogenic porcine reproductive and respiratory syndrome virus with host cellular proteins using high throughput proteomics and identification of HSP70 as a cellular factor for virus replication. JOURNAL OF PROTEOMICS, 146, 58-69. doi:10.1016/j.jprot.2016.06.019

    DOI: 10.1016/j.jprot.2016.06.019

    Elucidation of the Cellular Interactome of Ebola Virus Nucleoprotein and Identification of Therapeutic Targets (Journal article)

    Garcia-Dorival, I., Wu, W., Armstrong, S. D., Barr, J. N., Carroll, M. W., Hewson, R., & Hiscox, J. A. (2016). Elucidation of the Cellular Interactome of Ebola Virus Nucleoprotein and Identification of Therapeutic Targets. JOURNAL OF PROTEOME RESEARCH, 15(12), 4290-4303. doi:10.1021/acs.jproteome.6b00337

    DOI: 10.1021/acs.jproteome.6b00337

    Heat Shock Protein 70 Family Members Interact with Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus Nucleocapsid Proteins and Perform a Functional Role in the Nairovirus Replication Cycle (Journal article)

    Surtees, R., Dowall, S. D., Shaw, A., Armstrong, S., Hewson, R., Carroll, M. W., . . . Barr, J. N. (2016). Heat Shock Protein 70 Family Members Interact with Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus Nucleocapsid Proteins and Perform a Functional Role in the Nairovirus Replication Cycle. JOURNAL OF VIROLOGY, 90(20), 9305-9316. doi:10.1128/JVI.00661-16

    DOI: 10.1128/JVI.00661-16

    Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of Infection (Journal article)

    Marriott, A. C., Dennis, M., Kane, J. A., Gooch, K. E., Hatch, G., Sharpe, S., . . . Carroll, M. W. (2016). Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of Infection. PLOS ONE, 11(6). doi:10.1371/journal.pone.0157887

    DOI: 10.1371/journal.pone.0157887

    MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection (Journal article)

    Gao, J., Xiao, S., Xiao, Y., Wang, X., Zhang, C., Zhao, Q., . . . Zhou, E. -M. (2016). MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection. SCIENTIFIC REPORTS, 6. doi:10.1038/srep25120

    DOI: 10.1038/srep25120

    Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Protein Interacts with Nsp9 and Cellular DHX9 To Regulate Viral RNA Synthesis (Journal article)

    Liu, L., Tian, J., Nan, H., Tian, M., Li, Y., Xu, X., . . . Chen, H. (2016). Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Protein Interacts with Nsp9 and Cellular DHX9 To Regulate Viral RNA Synthesis. JOURNAL OF VIROLOGY, 90(11), 5384-5398. doi:10.1128/JVI.03216-15

    DOI: 10.1128/JVI.03216-15

    Real-time, portable genome sequencing for Ebola surveillance (Journal article)

    Quick, J., Loman, N. J., Duraffour, S., Simpson, J. T., Severi, E., Cowley, L., . . . Carroll, M. W. (2016). Real-time, portable genome sequencing for Ebola surveillance. NATURE, 530(7589), 228-+. doi:10.1038/nature16996

    DOI: 10.1038/nature16996

    The role of the PI3K/AKT signalling pathway during avian infectious bronchitis infection (Thesis / Dissertation)

    Batra, A. (2016, December 20). The role of the PI3K/AKT signalling pathway during avian infectious bronchitis infection.

    2015

    Glycoprotein 5 of porcine reproductive and respiratory syndrome virus strain SD16 inhibits viral replication and causes G2/M cell cycle arrest, but does not induce cellular apoptosis in Marc-145 cells (Journal article)

    Mu, Y., Li, L., Zhang, B., Huang, B., Gao, J., Wang, X., . . . Zhou, E. -M. (2015). Glycoprotein 5 of porcine reproductive and respiratory syndrome virus strain SD16 inhibits viral replication and causes G2/M cell cycle arrest, but does not induce cellular apoptosis in Marc-145 cells. VIROLOGY, 484, 136-145. doi:10.1016/j.virol.2015.05.019

    DOI: 10.1016/j.virol.2015.05.019

    Human respiratory syncytial virus non-structural protein NS1 modifies miR-24 expression via transforming growth factor-β. (Journal article)

    Bakre, A., Wu, W., Hiscox, J., Spann, K., Teng, M. N., & Tripp, R. A. (2015). Human respiratory syncytial virus non-structural protein NS1 modifies miR-24 expression via transforming growth factor-β.. The Journal of general virology, 96(11), 3179-3191. doi:10.1099/jgv.0.000261

    DOI: 10.1099/jgv.0.000261

    Intranasal inoculation of sows with highly pathogenic porcine reproductive and respiratory syndrome virus at mid-gestation causes transplacental infection of fetuses (Journal article)

    Wang, T., Wang, X., Li, X. -A., Zhang, M., Liu, S., Zhao, X., . . . Xiao, Y. (2015). Intranasal inoculation of sows with highly pathogenic porcine reproductive and respiratory syndrome virus at mid-gestation causes transplacental infection of fetuses. VETERINARY RESEARCH, 46. doi:10.1186/s13567-015-0283-z

    DOI: 10.1186/s13567-015-0283-z

    Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach (Journal article)

    Aljabr, W., Touzelet, O., Pollakis, G., Wu, W., Munday, D. C., Hughes, M., . . . Hiscox, J. A. (2016). Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach. JOURNAL OF VIROLOGY, 90(10), 4876-4888. doi:10.1128/JVI.02349-15

    DOI: 10.1128/JVI.02349-15

    MicroRNA miR-24-3p Promotes Porcine Reproductive and Respiratory Syndrome Virus Replication through Suppression of Heme Oxygenase-1 Expression (Journal article)

    Xiao, S., Wang, X., Ni, H., Li, N., Zhang, A., Liu, H., . . . Zhou, E. -M. (2015). MicroRNA miR-24-3p Promotes Porcine Reproductive and Respiratory Syndrome Virus Replication through Suppression of Heme Oxygenase-1 Expression. JOURNAL OF VIROLOGY, 89(8), 4494-4503. doi:10.1128/JVI.02810-14

    DOI: 10.1128/JVI.02810-14

    Resolution of the cellular proteome of the nucleocapsid protein from a highly pathogenic isolate of porcine reproductive and respiratory syndrome virus identifies PARP-1 as a cellular target whose interaction is critical for virus biology (Journal article)

    Liu, L., Lear, Z., Hughes, D. J., Wu, W., Zhou, E. -M., Whitehouse, A., . . . Hiscox, J. A. (2015). Resolution of the cellular proteome of the nucleocapsid protein from a highly pathogenic isolate of porcine reproductive and respiratory syndrome virus identifies PARP-1 as a cellular target whose interaction is critical for virus biology. VETERINARY MICROBIOLOGY, 176(1-2), 109-119. doi:10.1016/j.vetmic.2014.11.023

    DOI: 10.1016/j.vetmic.2014.11.023

    Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa (Journal article)

    Carroll, M. W., Matthews, D. A., Hiscox, J. A., Elmore, M. J., Pollakis, G., Rambaut, A., . . . Guenther, S. (2015). Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa. NATURE, 524(7563), 97-U201. doi:10.1038/nature14594

    DOI: 10.1038/nature14594

    The crystal structure of the Hazara virus nucleocapsid protein (Journal article)

    Surtees, R., Ariza, A., Punch, E. K., Trinh, C. H., Dowall, S. D., Hewson, R., . . . Edwards, T. A. (2015). The crystal structure of the Hazara virus nucleocapsid protein. BMC STRUCTURAL BIOLOGY, 15. doi:10.1186/s12900-015-0051-3

    DOI: 10.1186/s12900-015-0051-3

    2014

    Anti-idiotypic antibodies reduce efficacy of the attenuated vaccine against highly pathogenic PRRSV challenge (Journal article)

    Yu, Y., Cai, X., Wang, G., Kong, N., Liu, Y., Xiao, Y., . . . Zhou, E. -M. (2014). Anti-idiotypic antibodies reduce efficacy of the attenuated vaccine against highly pathogenic PRRSV challenge. BMC VETERINARY RESEARCH, 10. doi:10.1186/1746-6148-10-39

    DOI: 10.1186/1746-6148-10-39

    Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation (Journal article)

    Tanner, S. J., Ariza, A., Richard, C. -A., Kyle, H. F., Dods, R. L., Blondot, M. -L., . . . Barr, J. N. (2014). Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(4), 1580-1585. doi:10.1073/pnas.1317262111

    DOI: 10.1073/pnas.1317262111

    Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicity (Journal article)

    Dowall, S. D., Matthews, D. A., Garcia-Dorival, I., Taylor, I., Kenny, J., Hertz-Fowler, C., . . . Hiscox, J. A. (2014). Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicity. GENOME BIOLOGY, 15(11). doi:10.1186/s13059-014-0540-x

    DOI: 10.1186/s13059-014-0540-x

    Elucidation of the Ebola Virus VP24 Cellular Interactome and Disruption of Virus Biology through Targeted Inhibition of Host-Cell Protein Function (Journal article)

    Garcia-Dorival, I., Wu, W., Dowall, S., Armstrong, S., Touzelet, O., Wastling, J., . . . Hiscox, J. A. (2014). Elucidation of the Ebola Virus VP24 Cellular Interactome and Disruption of Virus Biology through Targeted Inhibition of Host-Cell Protein Function. JOURNAL OF PROTEOME RESEARCH, 13(11), 5120-5135. doi:10.1021/pr500556d

    DOI: 10.1021/pr500556d

    Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host cell protein function. (Journal article)

    García-Dorival, I., Wu, W., Dowall, S., Armstrong, S., Touzelet, O., Wastling, J., . . . Hiscox, J. A. (2014). Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host cell protein function.. Journal of Proteome Research.

    Factors affecting de novo RNA synthesis and back-priming by the respiratory syncytial virus polymerase (Journal article)

    Noton, S. L., Aljabr, W., Hiscox, J. A., Matthews, D. A., & Fearns, R. (2014). Factors affecting de novo RNA synthesis and back-priming by the respiratory syncytial virus polymerase. VIROLOGY, 462, 318-327. doi:10.1016/j.virol.2014.05.032

    DOI: 10.1016/j.virol.2014.05.032

    GP5 expression in Marc-145 cells inhibits porcine reproductive and respiratory syndrome virus infection by inducing beta interferon activity (Journal article)

    Gao, J., Ji, P., Zhang, M., Wang, X., Li, N., Wang, C., . . . Zhou, E. -M. (2014). GP5 expression in Marc-145 cells inhibits porcine reproductive and respiratory syndrome virus infection by inducing beta interferon activity. VETERINARY MICROBIOLOGY, 174(3-4), 409-418. doi:10.1016/j.vetmic.2014.09.030

    DOI: 10.1016/j.vetmic.2014.09.030

    Heme oxygenase-1 acts as an antiviral factor for porcine reproductive and respiratory syndrome virus infection and over-expression inhibits virus replication in vitro (Journal article)

    Xiao, S., Zhang, A., Zhang, C., Ni, H., Gao, J., Wang, C., . . . Zhou, E. -M. (2014). Heme oxygenase-1 acts as an antiviral factor for porcine reproductive and respiratory syndrome virus infection and over-expression inhibits virus replication in vitro. ANTIVIRAL RESEARCH, 110, 60-69. doi:10.1016/j.antiviral.2014.07.011

    DOI: 10.1016/j.antiviral.2014.07.011

    Heme oxygenase-1 acts as an antiviral factor for porcine reproductive and respiratory syndrome virus infection and over-expression inhibits virus replication in vitro. (Journal article)

    Xiao, S., Zhang, A., Zhang, C., Ni, H., Gao, J., Wang, C., . . . Zhou, E. M. (2014). Heme oxygenase-1 acts as an antiviral factor for porcine reproductive and respiratory syndrome virus infection and over-expression inhibits virus replication in vitro.. Anti-viral research, 110, 60-69.

    Interactome Analysis of the Human Respiratory Syncytial Virus RNA Polymerase Complex Identifies Protein Chaperones as Important Cofactors That Promote L-Protein Stability and RNA Synthesis (Journal article)

    Munday, D. C., Wu, W., Smith, N., Fix, J., Noton, S. L., Galloux, M., . . . Hiscox, J. A. (2015). Interactome Analysis of the Human Respiratory Syncytial Virus RNA Polymerase Complex Identifies Protein Chaperones as Important Cofactors That Promote L-Protein Stability and RNA Synthesis. JOURNAL OF VIROLOGY, 89(2), 917-930. doi:10.1128/JVI.01783-14

    DOI: 10.1128/JVI.01783-14

    Proteomic analysis of mitochondria in respiratory epithelial cells infected with human respiratory syncytial virus and functional implications for virus and cell biology (Journal article)

    Munday, D. C., Howell, G., Barr, J. N., & Hiscox, J. A. (2015). Proteomic analysis of mitochondria in respiratory epithelial cells infected with human respiratory syncytial virus and functional implications for virus and cell biology. JOURNAL OF PHARMACY AND PHARMACOLOGY, 67(3), 300-318. doi:10.1111/jphp.12349

    DOI: 10.1111/jphp.12349

    2013

    Characterization of antigenic domains and epitopes in the ORF3 protein of a Chinese isolate of avian hepatitis E virus (Journal article)

    Zhao, Q., Sun, Y. -N., Hu, S. -B., Wang, X. -J., Xiao, Y. -H., Hsu, W. H., . . . Zhou, E. -M. (2013). Characterization of antigenic domains and epitopes in the ORF3 protein of a Chinese isolate of avian hepatitis E virus. Veterinary Microbiology, 167(3-4), 242-249. doi:10.1016/j.vetmic.2013.08.006

    DOI: 10.1016/j.vetmic.2013.08.006

    Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization. (Journal article)

    Ariza, A., Tanner, S. J., Walter, C. T., Dent, K. C., Shepherd, D. A., Wu, W., . . . Edwards, T. A. (2013). Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization.. Nucleic acids research, 41(11), 5912-5926. doi:10.1093/nar/gkt268

    DOI: 10.1093/nar/gkt268

    PK-15cells transfected with porcine CD163 by PiggyBac transposon system are susceptible to porcine reproductive and respiratory syndrome virus (Journal article)

    Wang, X., Wei, R., Li, Q., Liu, H., Huang, B., Gao, J., . . . Zhou, E. -M. (2013). PK-15cells transfected with porcine CD163 by PiggyBac transposon system are susceptible to porcine reproductive and respiratory syndrome virus. Journal of Virological Methods, 193(2), 383-390. doi:10.1016/j.jviromet.2013.06.035

    DOI: 10.1016/j.jviromet.2013.06.035

    The Asymmetric Structure of an Icosahedral Virus Bound to Its Receptor Suggests a Mechanism for Genome Release (Journal article)

    Dent, K., Thompson, R., Barker, A., Hiscox, J., Barr, J., Stockley, P., & Ranson, N. (2013). The Asymmetric Structure of an Icosahedral Virus Bound to Its Receptor Suggests a Mechanism for Genome Release. Structure, 21(7), 1225-1234. doi:10.1016/j.str.2013.05.012

    DOI: 10.1016/j.str.2013.05.012

    The Cellular Interactome of the Coronavirus Infectious Bronchitis Virus Nucleocapsid Protein and Functional Implications for Virus Biology (Journal article)

    Emmott, E., Munday, D., Bickerton, E., Britton, P., Rodgers, M. A., Whitehouse, A., . . . Hiscox, J. A. (2013). The Cellular Interactome of the Coronavirus Infectious Bronchitis Virus Nucleocapsid Protein and Functional Implications for Virus Biology. Journal of Virology, 87(17), 9486-9500. doi:10.1128/JVI.00321-13

    DOI: 10.1128/JVI.00321-13

    2012

    A quantitative proteomic analysis of lung epithelial (A549) cells infected with 2009 pandemic influenza A virus using stable isotope labelling with amino acids in cell culture. (Journal article)

    Dove, B. K., Surtees, R., Bean, T. J., Munday, D., Wise, H. M., Digard, P., . . . Hiscox, J. A. (2012). A quantitative proteomic analysis of lung epithelial (A549) cells infected with 2009 pandemic influenza A virus using stable isotope labelling with amino acids in cell culture.. Proteomics, 12, 1431-1436.

    An interactome map of the nucleocapsid protein from a highly pathogenic North American porcine reproductive and respiratory syndrome virus strain generated using SILAC-based quantitative proteomics. (Journal article)

    Jourdan, S. S., Osorio, F., & Hiscox, J. A. (2012). An interactome map of the nucleocapsid protein from a highly pathogenic North American porcine reproductive and respiratory syndrome virus strain generated using SILAC-based quantitative proteomics.. Proteomics, 12, 1015-1023.

    Biophysical characterisation of the nucleocapsid protein from a highly pathogenic porcine reproductive and respiratory syndrome virus strain. (Journal article)

    Jourdan, S. S., Osorio, F. A., & Hiscox, J. A. (2012). Biophysical characterisation of the nucleocapsid protein from a highly pathogenic porcine reproductive and respiratory syndrome virus strain.. Biochem Biophys Res Commun., 419, 137-141.

    Different NF-κB activation characteristics of human respiratory syncytial virus subgroups A and B. (Journal article)

    Wu, W., Macdonald, A., Hiscox, J. A., & Barr, J. N. (2012). Different NF-κB activation characteristics of human respiratory syncytial virus subgroups A and B.. Microb Pathog., 52, 184-191.

    Structure, function and evolution of the Crimean-Congo hemorrhagic fever virus nucleocapsid protein. (Journal article)

    Carter, S. D., Surtees, R., Walter, C. T., Ariza, A., Bergeron, E., Nichol, S. T., . . . Barr, J. N. (2012). Structure, function and evolution of the Crimean-Congo hemorrhagic fever virus nucleocapsid protein.. Journal of Virology, 86, 10914-10923.

    The Interactome of the Human Respiratory Syncytial Virus NS1 Protein Highlights Multiple Effects on Host Cell Biology (Journal article)

    Wu, W., Tran, K. C., Teng, M. N., Heesom, K. J., Matthews, D. A., Barr, J. N., & Hiscox, J. A. (2012). The Interactome of the Human Respiratory Syncytial Virus NS1 Protein Highlights Multiple Effects on Host Cell Biology. Journal of Virology, 86(15), 7777-7789. doi:10.1128/JVI.00460-12

    DOI: 10.1128/JVI.00460-12

    Using SILAC and quantitative proteomics to investigate the interactions between viral and host proteomes. (Journal article)

    Munday, D. C., Surtees, R., Emmott, E., Dove, B. K., Digard, P., Barr, J. N., . . . Hiscox, J. A. (2012). Using SILAC and quantitative proteomics to investigate the interactions between viral and host proteomes.. Proteomics, 12, 666-672.

    2011

    Characterization of the Interaction between Human Respiratory Syncytial Virus and the Cell Cycle in Continuous Cell Culture and Primary Human Airway Epithelial Cells (Journal article)

    Wu, W., Munday, D. C., Howell, G., Platt, G., Barr, J. N., & Hiscox, J. A. (2011). Characterization of the Interaction between Human Respiratory Syncytial Virus and the Cell Cycle in Continuous Cell Culture and Primary Human Airway Epithelial Cells. JOURNAL OF VIROLOGY, 85(19), 10300-10309. doi:10.1128/JVI.05164-11

    DOI: 10.1128/JVI.05164-11

    Nucleolar NF-κB/RelA mediates apoptosis by causing cytoplasmic relocalization of nucleophosmin (Journal article)

    Khandelwal, N., Simpson, J., Taylor, G., Rafique, S., Whitehouse, A., Hiscox, J., & Stark, L. A. (2011). Nucleolar NF-κB/RelA mediates apoptosis by causing cytoplasmic relocalization of nucleophosmin. Cell Death & Differentiation, 18(12), 1889-1903. doi:10.1038/cdd.2011.79

    DOI: 10.1038/cdd.2011.79

    2010

    Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability (Journal article)

    Carter, S. D., Dent, K. C., Atkins, E., Foster, T. L., Verow, M., Gorny, P., . . . Barr, J. N. (2010). Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability. FEBS Letters, 584(13), 2786-2790. doi:10.1016/j.febslet.2010.05.006

    DOI: 10.1016/j.febslet.2010.05.006

    Elucidation of the avian nucleolar proteome by quantitative proteomics using SILAC and changes in cells infected with the coronavirus infectious bronchitis virus (Journal article)

    Emmott, E., Smith, C., Emmett, S. R., Dove, B. K., & Hiscox, J. A. (2010). Elucidation of the avian nucleolar proteome by quantitative proteomics using SILAC and changes in cells infected with the coronavirus infectious bronchitis virus. PROTEOMICS, 10(19), 3558-3562. doi:10.1002/pmic.201000139

    DOI: 10.1002/pmic.201000139

    Nucleolar proteomics and viral infection (Journal article)

    Hiscox, J. A., Whitehouse, A., & Matthews, D. A. (2010). Nucleolar proteomics and viral infection. PROTEOMICS, 10(22), 4077-4086. doi:10.1002/pmic.201000251

    DOI: 10.1002/pmic.201000251

    Quantitative Proteomics Using SILAC Coupled to LC−MS/MS Reveals Changes in the Nucleolar Proteome in Influenza A Virus-Infected Cells (Journal article)

    Emmott, E., Wise, H., Loucaides, E. M., Matthews, D. A., Digard, P., & Hiscox, J. A. (2010). Quantitative Proteomics Using SILAC Coupled to LC−MS/MS Reveals Changes in the Nucleolar Proteome in Influenza A Virus-Infected Cells. Journal of Proteome Research, 9(10), 5335-5345. doi:10.1021/pr100593g

    DOI: 10.1021/pr100593g

    Quantitative Proteomics Using Stable Isotope Labeling with Amino Acids in Cell Culture Reveals Changes in the Cytoplasmic, Nuclear, and Nucleolar Proteomes in Vero Cells Infected with the Coronavirus Infectious Bronchitis Virus (Journal article)

    Emmott, E., Rodgers, M. A., Macdonald, A., McCrory, S., Ajuh, P., & Hiscox, J. A. (2010). Quantitative Proteomics Using Stable Isotope Labeling with Amino Acids in Cell Culture Reveals Changes in the Cytoplasmic, Nuclear, and Nucleolar Proteomes in Vero Cells Infected with the Coronavirus Infectious Bronchitis Virus. Molecular & Cellular Proteomics, 9(9), 1920-1936. doi:10.1074/mcp.M900345-MCP200

    DOI: 10.1074/mcp.M900345-MCP200

    Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus subgroup B using SILAC coupled to LC-MS/MS (Journal article)

    C. Munday, D., Hiscox, J. A., & Barr, J. N. (2010). Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus subgroup B using SILAC coupled to LC-MS/MS. PROTEOMICS, 10(23), 4320-4334. doi:10.1002/pmic.201000228

    DOI: 10.1002/pmic.201000228

    2009

    Nucleolar targeting: the hub of the matter (Journal article)

    Emmott, E., & Hiscox, J. A. (2009). Nucleolar targeting: the hub of the matter. EMBO reports, 10(3), 231-238. doi:10.1038/embor.2009.14

    DOI: 10.1038/embor.2009.14

    2008

    A model for the dynamic nuclear/nucleolar/cytoplasmic trafficking of the porcine reproductive and respiratory syndrome virus (PRRSV) nucleocapsid protein based on live cell imaging (Journal article)

    You, J. -H., Howell, G., Pattnaik, A. K., Osorio, F. A., & Hiscox, J. A. (2008). A model for the dynamic nuclear/nucleolar/cytoplasmic trafficking of the porcine reproductive and respiratory syndrome virus (PRRSV) nucleocapsid protein based on live cell imaging. Virology, 378(1), 34-47. doi:10.1016/j.virol.2008.04.037

    DOI: 10.1016/j.virol.2008.04.037

    Production of an infectious Herpesvirus saimiri-based episomally maintained amplicon system (Journal article)

    MACNAB, S., WHITE, R., HISCOX, J., & WHITEHOUSE, A. (2008). Production of an infectious Herpesvirus saimiri-based episomally maintained amplicon system. Journal of Biotechnology, 134(3-4), 287-296. doi:10.1016/j.jbiotec.2008.01.012

    DOI: 10.1016/j.jbiotec.2008.01.012

    Role of phosphorylation clusters in the biology of the coronavirus infectious bronchitis virus nucleocapsid protein (Journal article)

    Spencer, K. -A., Dee, M., Britton, P., & Hiscox, J. A. (2008). Role of phosphorylation clusters in the biology of the coronavirus infectious bronchitis virus nucleocapsid protein. Virology, 370(2), 373-381. doi:10.1016/j.virol.2007.08.016

    DOI: 10.1016/j.virol.2007.08.016

    Viral nucleolar localisation signals determine dynamic trafficking within the nucleolus (Journal article)

    Emmott, E., Dove, B. K., Howell, G., Chappell, L. A., Reed, M. L., Boyne, J. R., . . . Hiscox, J. A. (2008). Viral nucleolar localisation signals determine dynamic trafficking within the nucleolus. Virology, 380(2), 191-202. doi:10.1016/j.virol.2008.05.032

    DOI: 10.1016/j.virol.2008.05.032

    2007

    Cell cycle dependent nucleolar localization of the coronavirus nucleocapsid protein (Journal article)

    Cawood, R., Harrison, S. M., Dove, B. K., Reed, M. L., & Hiscox, J. A. (2007). Cell cycle dependent nucleolar localization of the coronavirus nucleocapsid protein. Cell Cycle, 6(7), 863-867. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/17426449

    Characterisation of cyclin D1 down-regulation in coronavirus infected cells (Journal article)

    Harrison, S. M., Dove, B. K., Rothwell, L., Kaiser, P., Tarpey, I., Brooks, G., & Hiscox, J. A. (2007). Characterisation of cyclin D1 down-regulation in coronavirus infected cells. FEBS Letters, 581(7), 1275-1286. doi:10.1016/j.febslet.2007.02.039

    DOI: 10.1016/j.febslet.2007.02.039

    Characterization of the Nuclear Export Signal in the Coronavirus Infectious Bronchitis Virus Nucleocapsid Protein (Journal article)

    Reed, M. L., Howell, G., Harrison, S. M., Spencer, K. -A., & Hiscox, J. A. (2007). Characterization of the Nuclear Export Signal in the Coronavirus Infectious Bronchitis Virus Nucleocapsid Protein. Journal of Virology, 81(8), 4298-4304. doi:10.1128/JVI.02239-06

    DOI: 10.1128/JVI.02239-06

    Lithium chloride inhibits the coronavirus infectious bronchitis virus in cell culture (Journal article)

    Harrison, S. M., Tarpey, I., Rothwell, L., Kaiser, P., & Hiscox, J. A. (2007). Lithium chloride inhibits the coronavirus infectious bronchitis virus in cell culture. Avian Pathology, 36(2), 109-114. doi:10.1080/03079450601156083

    DOI: 10.1080/03079450601156083

    RNA viruses: hijacking the dynamic nucleolus (Journal article)

    Hiscox, J. A. (2007). RNA viruses: hijacking the dynamic nucleolus. Nature Reviews Microbiology, 5(2), 119-127. doi:10.1038/nrmicro1597

    DOI: 10.1038/nrmicro1597

    Recombinant viral proteins for use in diagnostic ELISAs to detect virus infection (Journal article)

    Spencer, K. -A., Osorio, F. A., & Hiscox, J. A. (2007). Recombinant viral proteins for use in diagnostic ELISAs to detect virus infection. Vaccine, 25(30), 5653-5659. doi:10.1016/j.vaccine.2007.02.053

    DOI: 10.1016/j.vaccine.2007.02.053

    Trafficking motifs in the SARS-coronavirus nucleocapsid protein (Journal article)

    You, J. -H., Reed, M. L., & Hiscox, J. A. (2007). Trafficking motifs in the SARS-coronavirus nucleocapsid protein. Biochemical and Biophysical Research Communications, 358(4), 1015-1020. doi:10.1016/j.bbrc.2007.05.036

    DOI: 10.1016/j.bbrc.2007.05.036

    2006

    Cell Cycle Perturbations Induced by Infection with the Coronavirus Infectious Bronchitis Virus and Their Effect on Virus Replication (Journal article)

    Dove, B., Brooks, G., Bicknell, K., Wurm, T., & Hiscox, J. A. (2006). Cell Cycle Perturbations Induced by Infection with the Coronavirus Infectious Bronchitis Virus and Their Effect on Virus Replication. Journal of Virology, 80(8), 4147-4156. doi:10.1128/JVI.80.8.4147-4156.2006

    DOI: 10.1128/JVI.80.8.4147-4156.2006

    Changes in nucleolar morphology and proteins during infection with the coronavirus infectious bronchitis virus (Journal article)

    Dove, B. K., You, J. -H., Reed, M. L., Emmett, S. R., Brooks, G., & Hiscox, J. A. (2006). Changes in nucleolar morphology and proteins during infection with the coronavirus infectious bronchitis virus. Cellular Microbiology, 8(7), 1147-1157. doi:10.1111/j.1462-5822.2006.00698.x

    DOI: 10.1111/j.1462-5822.2006.00698.x

    Characterisation of the RNA binding properties of the coronavirus infectious bronchitis virus nucleocapsid protein amino-terminal region (Journal article)

    Spencer, K. -A., & Hiscox, J. A. (2006). Characterisation of the RNA binding properties of the coronavirus infectious bronchitis virus nucleocapsid protein amino-terminal region. FEBS Letters, 580(25), 5993-5998. doi:10.1016/j.febslet.2006.09.052

    DOI: 10.1016/j.febslet.2006.09.052

    Delineation and Modelling of a Nucleolar Retention Signal in the Coronavirus Nucleocapsid Protein (Journal article)

    Reed, M. L., Dove, B. K., Jackson, R. M., Collins, R., Brooks, G., & Hiscox, J. A. (2006). Delineation and Modelling of a Nucleolar Retention Signal in the Coronavirus Nucleocapsid Protein. Traffic, 7(7), 833-848. doi:10.1111/j.1600-0854.2006.00424.x

    DOI: 10.1111/j.1600-0854.2006.00424.x

    Expression and structural analysis of infectious bronchitis virus nucleoprotein (Journal article)

    Spencer, K. A., & Hiscox, J. A. (2006). Expression and structural analysis of infectious bronchitis virus nucleoprotein. Adv Exp Med Biol, 581, 133-138. doi:10.1007/978-0-387-33012-9_23

    DOI: 10.1007/978-0-387-33012-9_23

    Infectious bronchitis coronavirus induces cell-cycle perturbations (Journal article)

    Dove, B. K., Bicknell, K., Brooks, G., Harrison, S., & Hiscox, J. A. (2006). Infectious bronchitis coronavirus induces cell-cycle perturbations. Adv Exp Med Biol, 581, 357-362. doi:10.1007/978-0-387-33012-9_63

    DOI: 10.1007/978-0-387-33012-9_63

    Three-dimensional reconstruction of the nucleolus using meta-confocal microscopy in cells expressing the coronavirus nucleoprotein (Journal article)

    You, J. H., Reed, M. L., Dove, B. K., & Hiscox, J. A. (2006). Three-dimensional reconstruction of the nucleolus using meta-confocal microscopy in cells expressing the coronavirus nucleoprotein. Adv Exp Med Biol, 581, 313-318. doi:10.1007/978-0-387-33012-9_55

    DOI: 10.1007/978-0-387-33012-9_55

    2005

    Mass Spectroscopic Characterization of the Coronavirus Infectious Bronchitis Virus Nucleoprotein and Elucidation of the Role of Phosphorylation in RNA Binding by Using Surface Plasmon Resonance (Journal article)

    Chen, H., Gill, A., Dove, B. K., Emmett, S. R., Kemp, C. F., Ritchie, M. A., . . . Hiscox, J. A. (2005). Mass Spectroscopic Characterization of the Coronavirus Infectious Bronchitis Virus Nucleoprotein and Elucidation of the Role of Phosphorylation in RNA Binding by Using Surface Plasmon Resonance. Journal of Virology, 79(2), 1164-1179. doi:10.1128/JVI.79.2.1164-1179.2005

    DOI: 10.1128/JVI.79.2.1164-1179.2005

    Nucleolin is regulated both at the level of transcription and translation (Journal article)

    Bicknell, K., Brooks, G., Kaiser, P., Chen, H., Dove, B. K., & Hiscox, J. A. (2005). Nucleolin is regulated both at the level of transcription and translation. Biochemical and Biophysical Research Communications, 332(3), 817-822. doi:10.1016/j.bbrc.2005.05.022

    DOI: 10.1016/j.bbrc.2005.05.022

    Subcellular localization of the severe acute respiratory syndrome coronavirus nucleocapsid protein (Journal article)

    You, J. (2005). Subcellular localization of the severe acute respiratory syndrome coronavirus nucleocapsid protein. Journal of General Virology, 86(12), 3303-3310. doi:10.1099/vir.0.81076-0

    DOI: 10.1099/vir.0.81076-0

    The cell cycle and virus infection (Journal article)

    Emmett, S. R., Dove, B., Mahoney, L., Wurm, T., & Hiscox, J. A. (2005). The cell cycle and virus infection. Methods Mol Biol, 296, 197-218. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/15576934

    2004

    ACE2: from vasopeptidase to SARS virus receptor (Journal article)

    Turner, A. J., Hiscox, J. A., & Hooper, N. M. (2004). ACE2: from vasopeptidase to SARS virus receptor. Trends in Pharmacological Sciences, 25(6), 291-294. doi:10.1016/j.tips.2004.04.001

    DOI: 10.1016/j.tips.2004.04.001

    2003

    Evaluation of a nucleoprotein-based enzyme-linked immunosorbent assay for the detection of antibodies against infectious bronchitis virus (Journal article)

    Chen, H., Coote, B., Atree, S., & Hiscox, J. A. (2003). Evaluation of a nucleoprotein-based enzyme-linked immunosorbent assay for the detection of antibodies against infectious bronchitis virus. Avian Pathology, 32(5), 519-526. doi:10.1080/0307945031000154125

    DOI: 10.1080/0307945031000154125

    The interaction of animal cytoplasmic RNA viruses with the nucleus to facilitate replication (Journal article)

    Hiscox, J. A. (2003). The interaction of animal cytoplasmic RNA viruses with the nucleus to facilitate replication. Virus Res, 95(1-2), 13-22. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12921992

    2002

    Interaction of the coronavirus nucleoprotein with nucleolar antigens and the host cell (Journal article)

    Chen, H., Wurm, T., Britton, P., Brooks, G., & Hiscox, J. A. (2002). Interaction of the coronavirus nucleoprotein with nucleolar antigens and the host cell. J Virol, 76(10), 5233-5250. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11967337

    The nucleolus – a gateway to viral infection? (Journal article)

    Hiscox, J. A. (2002). The nucleolus – a gateway to viral infection?. Archives of Virology, 147(6), 1077-1089. doi:10.1007/s00705-001-0792-0

    DOI: 10.1007/s00705-001-0792-0

    2001

    Enhancement of defective RNA expression vectors as potential vaccine delivery systems for avian infectious bronchitis virus (Journal article)

    Dove, B., Shaw, K., Hiscox, J., Cavanagh, D., & Britton, P. (2001). Enhancement of defective RNA expression vectors as potential vaccine delivery systems for avian infectious bronchitis virus. Adv Exp Med Biol, 494, 407-409. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11774500

    Localization to the Nucleolus Is a Common Feature of Coronavirus Nucleoproteins, and the Protein May Disrupt Host Cell Division (Journal article)

    Wurm, T., Chen, H., Hodgson, T., Britton, P., Brooks, G., & Hiscox, J. A. (2001). Localization to the Nucleolus Is a Common Feature of Coronavirus Nucleoproteins, and the Protein May Disrupt Host Cell Division. Journal of Virology, 75(19), 9345-9356. doi:10.1128/JVI.75.19.9345-9356.2001

    DOI: 10.1128/JVI.75.19.9345-9356.2001

    The Coronavirus Infectious Bronchitis Virus Nucleoprotein Localizes to the Nucleolus (Journal article)

    Hiscox, J. A., Wurm, T., Wilson, L., Britton, P., Cavanagh, D., & Brooks, G. (2001). The Coronavirus Infectious Bronchitis Virus Nucleoprotein Localizes to the Nucleolus. Journal of Virology, 75(1), 506-512. doi:10.1128/JVI.75.1.506-512.2001

    DOI: 10.1128/JVI.75.1.506-512.2001

    1997

    Cotranslational disassembly of flock house virus in a cell-free system (Journal article)

    Hiscox, J. A., & Ball, L. A. (1997). Cotranslational disassembly of flock house virus in a cell-free system. J Virol, 71(10), 7974-7977. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9311890

    1995

    Characterization of the transmissible gastroenteritis virus (TGEV) transcription initiation sequence. Characterization of TGEV TIS (Journal article)

    Hiscox, J. A., Mawditt, K. L., Cavanagh, D., & Britton, P. (1995). Characterization of the transmissible gastroenteritis virus (TGEV) transcription initiation sequence. Characterization of TGEV TIS. Adv Exp Med Biol, 380, 529-535. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/8830536

    Investigation of the control of coronavirus subgenomic mRNA transcription by using T7-generated negative-sense RNA transcripts (Journal article)

    Hiscox, J. A., Mawditt, K. L., Cavanagh, D., & Britton, P. (1995). Investigation of the control of coronavirus subgenomic mRNA transcription by using T7-generated negative-sense RNA transcripts. J Virol, 69(10), 6219-6227. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/7666523

    Quantification of individual subgenomic mRNA species during replication of the coronavirus transmissible gastroenteritis virus (Journal article)

    Hiscox, J. A., Cavanagh, D., & Britton, P. (1995). Quantification of individual subgenomic mRNA species during replication of the coronavirus transmissible gastroenteritis virus. Virus Res, 36(2-3), 119-130. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/7653093

    1993

    Control of TGEV mRNA transcription (Journal article)

    Hiscox, J., Pocock, D. H., & Britton, P. (1993). Control of TGEV mRNA transcription. Adv Exp Med Biol, 342, 99-104. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/8209778