Prof Julian Hiscox BSc PhD

Chair in Infection and Global Health Infection Biology

    Research

    Research on high consequence infectious diseases

    His laboratory uses RNA sequencing and proteomics as basis to study the functional interactions of high consequence infectious diseases and biological threats with the host. The laboratory focuses mainly on Ebola virus, MERS-coronavirus and ricin. For the West African Ebola virus outbreak many members of his team deployed to West Africa and he led the sequencing of diagnostic left over samples for the European Mobile Laboratory. In a series of papers, this data was used to track evolution of the virus, the interaction with the host and the role of co-infections in Ebola virus disease. The laboratory used machine learning approaches to identify a series of validated biomarkers that together with viral load information allowed the prediction of outcome (life/death) in patients acutely ill with Ebola virus disease. This can information can be used to inform case management and in the evaluation of medical countermeasures. His group have been working with scientists in Saudi Arabia on the analysis of samples from patients with MERS-coronavirus, particularly studying how the underlying microbiome may contribute to severe disease. Most recently, his laboratory have begun studies on SARS-CoV-2 and COVID-19.

    Research Grants

    Comparison of EBOV infection and Ebola virus disease in animal models and humans, and assessing animal models for MCM development

    FOOD AND DRUG ADMINISTATION (USA)

    October 2017 - September 2020

    Case Studentship Abbie Harrison

    DEFENCE SCIENCE & TECHNOLOGY LABORATORY (DSTL) (UK)

    October 2017 - September 2020

    Proteomic analysis of mouse lung tissue treated with ricin 20k

    DEFENCE SCIENCE & TECHNOLOGY LABORATORY (DSTL) (UK)

    February 2017 - June 2017

    Proteomic analysis of mouse lung tissue treated with ricin 12k

    DEFENCE SCIENCE & TECHNOLOGY LABORATORY (DSTL) (UK)

    January 2017 - April 2017

    Quantitative Proteomics

    THE PIRBRIGHT INSTITUTE (UK)

    December 2016 - November 2021

    Proteomic analysis of samples provided by Dstl

    DEFENCE SCIENCE & TECHNOLOGY LABORATORY (DSTL) (UK)

    October 2017 - September 2020

    Agreement for offsite supervision of research programme Sofia Riccio

    THE PIRBRIGHT INSTITUTE (UK)

    October 2017 - October 2021

    Case Award for Yan Ryan

    DEFENCE SCIENCE & TECHNOLOGY LABORATORY (DSTL) (UK)

    February 2019 - February 2022

    Zika Preparedness Latin American Network — ZikaPLAN

    EUROPEAN COMMISSION

    October 2016 - September 2020

    Ebola virus Correlates of Protection, Biomarkers of Disease Outcome and Mutations with Implications for Efficacy of Vaccines and Therapeutics

    FOOD AND DRUG ADMINISTATION (USA)

    September 2015 - September 2020

    Investigating the link between Zika virus infection and neurological disease in ex vivo and in vivo models

    DEPARTMENT FOR BUSINESS, ENERGY AND INDUSTRIAL STRATEGY (BEIS) (UK)

    March 2016 - March 2017

    Rapid sequencing of Ebola virus

    WORLD HEALTH ORGANISATION (SWITZERLAND)

    July 2016 - December 2016

    Interfering and Co-Evolving Prevention and Therapy

    DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) (USA)

    July 2017 - September 2019

    Sparking Impact

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    June 2013 - July 2014

    Pathogen Proteomics

    THE PIRBRIGHT INSTITUTE (UK)

    February 2013 - November 2016

    Bench fees for J Perez Lazo

    PRESIDENCIA DEL CONSEJO DE MINISTROS (PERU)

    October 2016 - September 2020

    EVIDENT - High throughput analysis of samples from the West African ebola outbreak

    EUROPEAN COMMISSION

    December 2014 - October 2016

    Health Protection Research Unit: Emerging Infections (including zoonoses) and Biological Threats.

    DEPARTMENT OF HEALTH (UK) (NIHR)

    April 2014 - March 2020

    EMBO Workshop on Integrating omic approaches to host pathogen interactions

    EUROPEAN MOLECULAR BIOLOGY ORGANISATION (GERMANY)

    November 2012 - September 2013

    Analysis of the function of infectious bronchitis virus accessory proteins - towards better vaccines

    THE PIRBRIGHT INSTITUTE (UK)

    October 2013 - September 2017

    Zana Mahmood - bench fees

    KURDISTAN REGIONAL GOVERNMENT (IRAQ)

    October 2014 - September 2015

    Waleed Al Jabr bench fees

    ROYAL EMBASSY OF SAUDI ARABIA

    October 2013 - September 2015

    Predicting Influenza severity by proteomics (PrInSeP).

    ALDER HEY CHILDREN'S NHS FOUNDATION TRUST (UK)

    January 2014 - June 2016

    The role of cellular RNA editing in human respiratory syncytial virus and influenza virus biology.

    MEDICAL RESEARCH COUNCIL (MRC)

    October 2012 - November 2015

    Research Collaborations

    Dr. Roger Hewson and Prof. Miles Carroll

    External: Health Protection Agency

    Collaborate on emerging viral pathogens

    Prof. Paul Digard

    External: University of Edinburgh

    Collaborate on an MRC funded project looking at the interaction of human respiratory syncytial virus and influenza A virus with the host.

    Dr. John N. Barr

    External: University of Leeds

    Investigating respiratory and emerging pathogens on joint MRC and Health Protection Agency funded projects.