Dr Guozheng Wang MBChB, MD, PhD.
Consultant Clinical Scientist and Honorary Professor Clinical Infection, Microbiology & Immunology
- +44 (0)151 706 4081
- Work email G.Wang@liverpool.ac.uk
- Personal Websitehttps://www.liverpool.ac.uk/infection-and-global-health/staff/guozheng-wang/
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2023
Immune dysregulation in sepsis: experiences, lessons and perspectives. (Journal article)
Cao, M., Wang, G., & Xie, J. (2023). Immune dysregulation in sepsis: experiences, lessons and perspectives.. Cell death discovery, 9(1), 465. doi:10.1038/s41420-023-01766-7Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia. (Journal article)
Abrams, S. T., Du, M., Shaw, R. J., Johnson, C., McGuinness, D., Schofield, J., . . . Toh, C. -H. (2023). Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia.. Journal of thrombosis and haemostasis : JTH, S1538-7836(23)00873-5. doi:10.1016/j.jtha.2023.12.008Are NETs a Novel, Exciting, Thrombosis Risk Marker? (Journal article)
Wang, G., Abrams, S. T., & Toh, C. -H. (2023). Are NETs a Novel, Exciting, Thrombosis Risk Marker?. Thrombosis and haemostasis. doi:10.1055/a-2187-0645Development of genomic phenotype and immunophenotype of acute respiratory distress syndrome using autophagy and metabolism-related genes. (Journal article)
Xia, F., Chen, H., Liu, Y., Huang, L., Meng, S., Xu, J., . . . Guo, F. (2023). Development of genomic phenotype and immunophenotype of acute respiratory distress syndrome using autophagy and metabolism-related genes.. Frontiers in immunology, 14, 1209959. doi:10.3389/fimmu.2023.1209959OC 78.5 Systemic Snakebite Envenoming Causes Histone-Induced Thrombocytopaenia (Journal article)
Schofield, J., Abrams, S., Alhamdi, Y., Ainsworth, S., Evans, C., Albulescu, L., . . . Toh, C. (2023). OC 78.5 Systemic Snakebite Envenoming Causes Histone-Induced Thrombocytopaenia. Research and Practice in Thrombosis and Haemostasis, 7, 100487. doi:10.1016/j.rpth.2023.100487PB0794 Fibrinogen Protects against Histone-Induced Thrombocytopaenia (Journal article)
Yong, J., Abrams, S., Alhamdi, Y., Wang, G., & Toh, C. (2023). PB0794 Fibrinogen Protects against Histone-Induced Thrombocytopaenia. Research and Practice in Thrombosis and Haemostasis, 7, 101370. doi:10.1016/j.rpth.2023.101370Targeted Destruction of S100A4 Inhibits Metastasis of Triple Negative Breast Cancer Cells (Journal article)
Ismail, T. M., Crick, R. G., Du, M., Shivkumar, U., Carnell, A., Barraclough, R., . . . Rudland, P. S. (2023). Targeted Destruction of S100A4 Inhibits Metastasis of Triple Negative Breast Cancer Cells. BIOMOLECULES, 13(7). doi:10.3390/biom13071099Cell-free histones and the cell-based model of coagulation. (Journal article)
Yong, J., Abrams, S. T., Wang, G., & Toh, C. -H. (2023). Cell-free histones and the cell-based model of coagulation.. Journal of thrombosis and haemostasis : JTH, S1538-7836(23)00340-9. doi:10.1016/j.jtha.2023.04.018Neutrophil Extracellular Traps Removal During Ex Vivo Lung Perfusion Improves Lung Function in Aspiration Damaged Porcine Lungs (Conference Paper)
Mittendorfer, M., Pierre, L., Kjellberg, G., Schofield, J., Abrams, S., Wang, G., . . . Lindstedt, S. (2023). Neutrophil Extracellular Traps Removal During Ex Vivo Lung Perfusion Improves Lung Function in Aspiration Damaged Porcine Lungs. In JOURNAL OF HEART AND LUNG TRANSPLANTATION Vol. 42 (pp. S115). Retrieved from https://www.webofscience.com/Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis (Journal article)
Abrams, S. T. T., Alhamdi, Y., Zi, M., Guo, F., Du, M., Wang, G., . . . Toh, C. -H. (2023). Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(4). doi:10.3390/ijms24043225Systemic snakebite envenoming causes histone-induced thrombocytopaenia (Conference Paper)
Schofield, J., Abrams, S., Alhamdi, Y., Ainsworth, S., Evans, C., Albulescu, L. -O., . . . Toh, C. -H. (2023). Systemic snakebite envenoming causes histone-induced thrombocytopaenia. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 201 (pp. 52-53). Retrieved from https://www.webofscience.com/2022
The Importance of Pore-Forming Toxins in Multiple Organ Injury and Dysfunction (Journal article)
Abrams, S. T. T., Wang, L., Yong, J., Yu, Q., Du, M., Alhamdi, Y., . . . Wang, G. (2022). The Importance of Pore-Forming Toxins in Multiple Organ Injury and Dysfunction. BIOMEDICINES, 10(12). doi:10.3390/biomedicines10123256The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia (Journal article)
Toh, C. -H., Wang, G., & Parker, A. L. (2022). The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia. CLINICAL MEDICINE, 22(2), 140-144. doi:10.7861/clinmed.2022-0006Extracellular histones cause intestinal epithelium injury and disrupt its barrier function in vitro and in vivo. (Journal article)
Chen, C., Lin, Z., Zhang, X., Zhang, X., Cheng, Z., Jin, T., . . . Xia, Q. (2022). Extracellular histones cause intestinal epithelium injury and disrupt its barrier function in vitro and in vivo.. Toxicology, 469, 153117. doi:10.1016/j.tox.2022.153117Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis (Journal article)
Alsabani, M., Abrams, S. T., Cheng, Z., Morton, B., Lane, S., Alosaimi, S., . . . Toh, C. -H. (2022). Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis. British Journal of Anaesthesia, 128(2), 283-293. doi:10.1016/j.bja.2021.10.0392021
Circulating histones play a central role in COVID-19-associated coagulopathy and mortality (Journal article)
Shaw, R. J., Abrams, S. T., Austin, J., Taylor, J. M., Lane, S., Dutt, T., . . . Toh, C. -H. (2021). Circulating histones play a central role in COVID-19-associated coagulopathy and mortality. HAEMATOLOGICA, 106(9), 2493-2498. doi:10.3324/haematol.2021.278492COVID-19 and immunothrombosis: emerging understanding and clinical management (Journal article)
Shaw, R. J., Bradbury, C., Abrams, S. T., Wang, G., & Toh, C. -H. (2021). COVID-19 and immunothrombosis: emerging understanding and clinical management. BRITISH JOURNAL OF HAEMATOLOGY, 194(3), 518-529. doi:10.1111/bjh.176642020
Extracellular histones stimulate collagen expression <i>in vitro</i> and promote liver fibrogenesis in a mouse model <i>via </i>the TLR4-MyD88 signaling pathway (Journal article)
Wang, Z., Cheng, Z. -X., Abrams, S. T., Lin, Z. -Q., Yates, E. D., Yu, Q., . . . Wang, G. -Z. (2020). Extracellular histones stimulate collagen expression <i>in vitro</i> and promote liver fibrogenesis in a mouse model <i>via </i>the TLR4-MyD88 signaling pathway. WORLD JOURNAL OF GASTROENTEROLOGY, 26(47), 7513-7527. doi:10.3748/wjg.v26.i47.7513Circulating Histone Levels Correlate with the Severity of COVID-19 and the Extent of Coagulation Activation and Inflammation (Conference Paper)
Shaw, R. J., Austin, J., Taylor, J., Dutt, T., Wang, G., Abrams, S. T., & Toh, C. H. (2020). Circulating Histone Levels Correlate with the Severity of COVID-19 and the Extent of Coagulation Activation and Inflammation. In BLOOD Vol. 136. doi:10.1182/blood-2020-142344Extracellular histones stimulate collagen expression and potentially promote liver fibrogenesis via TLR4-MyD88 signalling pathway (Preprint)
The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development (Journal article)
Cheng, Z., Abrams, S. T., Austin, J., Toh, J., Wang, S. S., Wang, Z., . . . Wang, G. (2020). The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development. MEDIATORS OF INFLAMMATION, 2020. doi:10.1155/2020/7418342The Critical Roles and Mechanisms of Immune Cell Death in Sepsis (Journal article)
Cheng, Z., Abrams, S. T., Toh, J., Wang, S. S., Wang, Z., Yu, Q., . . . Wang, G. (2020). The Critical Roles and Mechanisms of Immune Cell Death in Sepsis. FRONTIERS IN IMMUNOLOGY, 11. doi:10.3389/fimmu.2020.01918Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation (Journal article)
Abrams, S. T., Su, D., Sahraoui, Y., Lin, Z., Cheng, Z., Nesbitt, K., . . . Toh, C. -H. (2021). Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation. BLOOD, 137(1), 103-114. doi:10.1182/blood.2019002973Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria (Journal article)
Moxon, C. A., Alhamdi, Y., Storm, J., Toh, J. M. H., McGuinness, D., Ko, J. Y., . . . Toh, C. (n.d.). Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria. Blood Advances, 4(13), 2851-2864. doi:10.1182/bloodadvances.2019001258Complexes between C-Reactive Protein and Very Low Density Lipoprotein Delay Bacterial Clearance in Sepsis (Journal article)
Cheng, Z., Abrams, S. T., Toh, J., Wang, S. S., Downey, C., Ge, X., . . . Toh, C. -H. (2020). Complexes between C-Reactive Protein and Very Low Density Lipoprotein Delay Bacterial Clearance in Sepsis. Journal of Immunology, 204(10), 2712-2721. doi:10.4049/jimmunol.1900962Parasite histones mediate blood-brain barrier disruption in cerebral malaria. (Journal article)
Moxon, C., Alhamdi, Y., Storm, J., Toh, J., Ko, J. Y., Murphy, G., . . . Toh, C. -H. (2020). Parasite histones mediate blood-brain barrier disruption in cerebral malaria.. Clinical medicine (London, England), 20(Suppl 2), s96-s97. doi:10.7861/clinmed.20-2-s96Direct interaction of metastasis-inducing S100P protein with tubulin causes enhanced cell migration without changes in cell adhesion (Journal article)
Du, M., Wang, G., Barsukov, I. L., Gross, S. R., Smith, R., & Rudland, P. S. (2020). Direct interaction of metastasis-inducing S100P protein with tubulin causes enhanced cell migration without changes in cell adhesion. BIOCHEMICAL JOURNAL, 477(6), 1159-1178. doi:10.1042/BCJ20190644A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit. (Journal article)
Abrams, S., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2020). A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit.. Clinical medicine (London, England), 20(Suppl 2), s114-s115. doi:10.7861/clinmed.20-2-s1142019
A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies (Conference Paper)
Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2019). A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies. In BLOOD Vol. 134. doi:10.1182/blood-2019-128493A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients (Journal article)
Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Lane, S., Welters, I. D., . . . Toh, C. -H. (2019). A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients. American journal of respiratory and critical care medicine, 200(07), 869-880. doi:10.1164/rccm.201811-2111ocCirculating Histones Are Major Mediators of Multiple Organ Dysfunction Syndrome in Acute Critical Illnesses. (Journal article)
Cheng, Z., Abrams, S. T., Alhamdi, Y., Toh, J., Yu, W., Wang, G., & Toh, C. -H. (2019). Circulating Histones Are Major Mediators of Multiple Organ Dysfunction Syndrome in Acute Critical Illnesses.. Critical care medicine, 47(8), e677-e684. doi:10.1097/ccm.0000000000003839Parasite histones mediate leak and coagulopathy in cerebral malaria (Preprint)
Parasite histones are associated with poor outcome in cerebral malaria (Conference Paper)
Moxon, C., Alhamdi, Y., Storm, J., Toh, J., Ko, J. Y., Murphy, G., . . . Toh, C. -H. (2019). Parasite histones are associated with poor outcome in cerebral malaria. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 185 (pp. 33). Retrieved from https://www.webofscience.com/2018
Histones Bind Prothrombin to Generate Alternative Prothrombinase Complexes That Can Disseminate Intravascular Coagulation (Conference Paper)
Abrams, S. T., Su, D., Sahraoui, Y., Alhamdi, Y., Wang, G., & Toh, C. H. (2018). Histones Bind Prothrombin to Generate Alternative Prothrombinase Complexes That Can Disseminate Intravascular Coagulation. In BLOOD Vol. 132. doi:10.1182/blood-2018-99-116117Proteolysis-targeting chimera (PROTAC) compounds to degrade S100A4 and inhibit breast cancer metastasis (Conference Paper)
Du, M., Wang, G., Ismail, T. M., Crick, R., Barraclough, R., Daimark, B. H., . . . Rudland, P. (2018). Proteolysis-targeting chimera (PROTAC) compounds to degrade S100A4 and inhibit breast cancer metastasis. In ANNALS OF ONCOLOGY Vol. 29. Retrieved from https://www.webofscience.com/Extracellular Histones Inhibit Complement Activation through Interacting with Complement Component 4 (Journal article)
Qaddoori, Y., Abrams, S. T., Mould, P., Alhamdi, Y., Christmas, S. E., Wang, G., & Toh, C. -H. (2018). Extracellular Histones Inhibit Complement Activation through Interacting with Complement Component 4. JOURNAL OF IMMUNOLOGY, 200(12), 4125-4133. doi:10.4049/jimmunol.17007792017
Systemic histone release disrupts plasmalemma and contributes to necrosis in acute pancreatitis (Journal article)
Szatmary, P., Liu, T., Abrams, S. T., Voronina, S., Wen, L., Chvanov, M., . . . Sutton, R. (2017). Systemic histone release disrupts plasmalemma and contributes to necrosis in acute pancreatitis. PANCREATOLOGY, 17(6), 884-892. doi:10.1016/j.pan.2017.10.002Extracellular histones inhibit complement activation through interactions with complement component C4b (Conference Paper)
Qaddoori, Y., Abrams, S. T., Su, D., Liu, T., Alhamdi, Y., Wang, G., & Toh, C. -H. (2017). Extracellular histones inhibit complement activation through interactions with complement component C4b. In MOLECULAR IMMUNOLOGY Vol. 89 (pp. 132). doi:10.1016/j.molimm.2017.06.067Accuracy of circulating histones in predicting persistent organ failure and mortality in patients with acute pancreatitis (Journal article)
Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Alhamdi, Y., Lin, Z., . . . Toh, C. H. (2017). Accuracy of circulating histones in predicting persistent organ failure and mortality in patients with acute pancreatitis. BRITISH JOURNAL OF SURGERY, 104(9), 1215-1225. doi:10.1002/bjs.10538Circulating histones associate with severity and play important roles in acute pancreatitis (Journal article)
Lin, Z., Cheng, Z., Liu, T., Wang, G., Sutton, R., & Toh, C. -H. (2017). Circulating histones associate with severity and play important roles in acute pancreatitis. Pancreatology, 17(3), S33. doi:10.1016/j.pan.2017.05.102143 The roles and mechanisms of pore-forming toxins in cardiac injury (Journal article)
Wang, G., Alhamdi, Y., & Toh, C. -H. (2017). 143 The roles and mechanisms of pore-forming toxins in cardiac injury. Heart, 103(Suppl 5), A107.1-A107. doi:10.1136/heartjnl-2017-311726.142Elevated Circulating Histones Associate With Multiple Organ Dysfunction Syndromes in Acute Pancreatitis (Journal article)
Liu, T., Huang, W., Abrams, S., Wang, L., Szatmary, P., Alhamdi, Y., . . . Sutton, R. (2016). Elevated Circulating Histones Associate With Multiple Organ Dysfunction Syndromes in Acute Pancreatitis. PANCREAS, 45(10), 1520. Retrieved from https://www.webofscience.com/THE ROLES AND MECHANISMS OF PORE-FORMING TOXINS IN CARDIAC INJURY (Conference Paper)
Wang, G., Alhamdi, Y., & Toh, C. -H. (2017). THE ROLES AND MECHANISMS OF PORE-FORMING TOXINS IN CARDIAC INJURY. In HEART Vol. 103 (pp. A107). Retrieved from https://www.webofscience.com/2016
Feasibility Study of Using the Housing Cases of Implantable Devices as Antennas (Journal article)
Kod, M., Zhou, J., Huang, Y., Stanley, M., Hussein, M., Sohrab, A. P., . . . Wang, G. (2016). Feasibility Study of Using the Housing Cases of Implantable Devices as Antennas. IEEE Access, 4, 6939-6949. doi:10.1109/ACCESS.2016.2613968Circulating histones accurately predict persistent organ failure and mortality in patients with acute pancreatitis within 24 h of admission (Journal article)
Liu, T., Huang, W., Szatmary, P., Abrams, S., Alhamdi, Y., Lin, Z., . . . Toh, C. -H. (2016). Circulating histones accurately predict persistent organ failure and mortality in patients with acute pancreatitis within 24 h of admission. Pancreatology, 16(3), S100-S101. doi:10.1016/j.pan.2016.05.338Circulating Histone Concentrations Differentially Affect the Predominance of Left or Right Ventricular Dysfunction in Critical Illness (Journal article)
Alhamdi, Y., Zi, M., Abrams, S., Liu, T., Su, D., Welters, I., . . . Toh, C. -H. (2016). Circulating Histone Concentrations Differentially Affect the Predominance of Left or Right Ventricular Dysfunction in Critical Illness. Critical Care Medicine, 44(05), e278-e288. doi:10.1097/CCM.0000000000001413Histone-Associated Thrombocytopenia in Patients Who Are Critically Ill (Journal article)
Alhamdi, Y., Abrams, S., Lane, S., Wang, G., & Toh, C. -H. (2016). Histone-Associated Thrombocytopenia in Patients Who Are Critically Ill. JAMA: Journal of the American Medical Association, 315(8), 817-819. doi:10.1001/jama.2016.0136EXTRACELLULAR HISTONES ENHANCE FACTOR XA MEDIATED PROTHROMBIN ACTIVATION WITHOUT PHOSPHOLIPID REQUIREMENT (Conference Paper)
Sahraoui, Y., Abrams, S., Su, D., Alhamdi, Y., Foley, J., Wang, G., & Toh, C. H. (2016). EXTRACELLULAR HISTONES ENHANCE FACTOR XA MEDIATED PROTHROMBIN ACTIVATION WITHOUT PHOSPHOLIPID REQUIREMENT. In HAEMATOLOGICA Vol. 101 (pp. 310). Retrieved from https://www.webofscience.com/Early prediction of major clinical outcomes of patients with acute pancreatitis by circulating histones (Journal article)
Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Greenhalf, W., Welters, I., . . . Toh, C. H. (2016). Early prediction of major clinical outcomes of patients with acute pancreatitis by circulating histones. Pancreatology, 16(1), S34. doi:10.1016/j.pan.2015.12.107Extracellular histones promote prothrombin activation in the absence of phospholipids (Conference Paper)
Sahraoui, Y., Abrams, S. T., Su, D., Alhamdi, Y., Foley, J., Wang, G., & Toh, C. H. (2016). Extracellular histones promote prothrombin activation in the absence of phospholipids. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 173 (pp. 19). Retrieved from https://www.webofscience.com/Histone-associated thrombocytopaenia is a significant cause of thrombocytopaenia in critical illness (Conference Paper)
Alhamdi, Y., Abrams, S. T., Lane, S., Wang, G., & Toh, C. H. (2016). Histone-associated thrombocytopaenia is a significant cause of thrombocytopaenia in critical illness. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 173 (pp. 19). Retrieved from https://www.webofscience.com/2015
Carbon Monoxide-Releasing Molecule-2 Reduces Intestinal Epithelial Tight-Junction Damage and Mortality in Septic Rats (Journal article)
Zhang, S., Zheng, S., Wang, X., Shi, Q., Wang, X., Yuan, S., . . . Ji, Z. (2015). Carbon Monoxide-Releasing Molecule-2 Reduces Intestinal Epithelial Tight-Junction Damage and Mortality in Septic Rats. PLOS ONE, 10(12). doi:10.1371/journal.pone.0145988Visualizing myocardial inflammation in a rat model of type 4 cardiorenal syndrome by dual-modality molecular imaging. (Journal article)
Chang, D., Wang, Y. -C., Zhang, S. -J., Bai, Y. -Y., Liu, D. -F., Zang, F. -C., . . . Ju, S. (2015). Visualizing myocardial inflammation in a rat model of type 4 cardiorenal syndrome by dual-modality molecular imaging.. Biomaterials, 68, 67-76. doi:10.1016/j.biomaterials.2015.07.050Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis (Journal article)
Ou, X., Cheng, Z., Liu, T., Tang, Z., Huang, W., Szatmary, P., . . . Wang, G. (2015). Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis. Pancreas, 44(7), 1089-1095. doi:10.1097/MPA.0000000000000416Circulating histones are major mediators of cardiac injury in patients with sepsis (Journal article)
Alhamdi, Y., Abrams, S. T., Cheng, Z., Jing, S., Su, D., Liu, Z., . . . Toh,, C. -H. (2015). Circulating histones are major mediators of cardiac injury in patients with sepsis. Critical Care Medicine, 43(10), 2094-2103. doi:10.1097/CCM.0000000000001162Synergistic Effects of Transplanted Endothelial Progenitor Cells and RWJ 67657 in Diabetic Ischemic Stroke Models (Journal article)
Bai, Y. -Y., Wang, L., Chang, D., Zhao, Z., Lu, C. -Q., Wang, G., & Ju, S. (2015). Synergistic Effects of Transplanted Endothelial Progenitor Cells and RWJ 67657 in Diabetic Ischemic Stroke Models. STROKE, 46(7), 1938-1946. doi:10.1161/STROKEAHA.114.008495S100P REGULATES CYTOSKELETON DYNAMICS TO PROMOTE CELL MIGRATION AND METASTASIS (Conference Paper)
Du, M., Wang, G., Barraclough, R., & Rudland, P. (2015). S100P REGULATES CYTOSKELETON DYNAMICS TO PROMOTE CELL MIGRATION AND METASTASIS. In EUROPEAN JOURNAL OF CANCER Vol. 51 (pp. E6-E7). doi:10.1016/j.ejca.2015.06.022Circulating histones contribute to acute respiratory distress syndrome in acute pancreatitis (Journal article)
Liu, T., Abrams, S., Szatmary, P., Cheng, Z., Huang, W., Ou, X., . . . Toh, C. -H. (2015). Circulating histones contribute to acute respiratory distress syndrome in acute pancreatitis. Pancreatology, 15(3), S63. doi:10.1016/j.pan.2015.05.242Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection (Journal article)
Alhamdi, Y., Neill, D., Abrams, S., Malak, H., Yahya, R., Barrett-Jolley, R., . . . Toh, C. -H. (2015). Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection. PLoS Pathogens, 11(5). doi:10.1371/journal.ppat.1004836Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis (Journal article)
Ou, X., Cheng, Z., Liu, T., Tang, Z., Huang, W., Szatmary, P., . . . Wang, G. (2015). Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis.Circulating Histones Target Acinar Cells and Exacerbate Injury in Experimental Acute Pancreatitis (Journal article)
Szatmary, P., Liu, T., Abrams, S., Wen, L., Huang, W., Wang, G., . . . Sutton, R. (2015). Circulating Histones Target Acinar Cells and Exacerbate Injury in Experimental Acute Pancreatitis. PANCREAS, 44(8), 1418. Retrieved from https://www.webofscience.com/Circulating histones disturb intracellular calcium homeostasis and cause calcium overload to induce cardiovascular abnormalities in sepsis (Journal article)
Alhamdi, Y., Abrams, S. T., Zi, M., Welters, I., Cartwright, E. J., Wang, G., & Toh, C. -H. (2015). Circulating histones disturb intracellular calcium homeostasis and cause calcium overload to induce cardiovascular abnormalities in sepsis. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13, 159. Retrieved from https://www.webofscience.com/Early Prediction of Major Clinical Outcomes of Patients With Acute Pancreatitis by Circulating Histones (Journal article)
Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Greenhalf, W., Welters, I., . . . Toh, C. H. (2015). Early Prediction of Major Clinical Outcomes of Patients With Acute Pancreatitis by Circulating Histones. PANCREAS, 44(8), 1393. Retrieved from https://www.webofscience.com/Histone-associated thrombocytopenia: a new cause of thrombocytopenia in critically ill patients (Journal article)
Alhamdi, Y., Abrams, S. T., Welters, I., Wang, G., & Toh, C. -H. (2015). Histone-associated thrombocytopenia: a new cause of thrombocytopenia in critically ill patients. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13, 94. Retrieved from https://www.webofscience.com/2014
Protective Effects of Carbon Monoxide-Releasing Molecule-2 on the Barrier Function of Intestinal Epithelial Cells (Journal article)
Mu, X., Pan, C., Zheng, S., Alhamdi, Y., Sun, B., Shi, Q., . . . Wang, G. (2014). Protective Effects of Carbon Monoxide-Releasing Molecule-2 on the Barrier Function of Intestinal Epithelial Cells. PLOS ONE, 9(8). doi:10.1371/journal.pone.0104032The Role of Neutrophil Extracellular Traps in Acute Pancreatitis (Journal article)
Szatmary, P., Liu, T., Wen, L., Huang, W., Awais, M., Wang, G., . . . Sutton, R. (2014). The Role of Neutrophil Extracellular Traps in Acute Pancreatitis. PANCREAS, 43(8), 1413. Retrieved from https://www.webofscience.com/Use of Citrullinated Histones and Circulating Nucleosomes in Early Prediction of Organ Failure in Acute Pancreatitis (Journal article)
Szatmary, P., Liu, T., Huang, W., Wang, G., Latawiec, D., Davies, K., . . . Sutton, R. (2014). Use of Citrullinated Histones and Circulating Nucleosomes in Early Prediction of Organ Failure in Acute Pancreatitis. PANCREAS, 43(8), 1413. Retrieved from https://www.webofscience.com/2013
Histone-Induced Lung Injury and Coagulation Activation Are Reduced By C-Reactive Protein In The Acute Phase Response (Conference Paper)
Abrams, S. T., Zhang, N., Wang, G., & Toh, C. -H. (2013). Histone-Induced Lung Injury and Coagulation Activation Are Reduced By C-Reactive Protein In The Acute Phase Response. In BLOOD Vol. 122. doi:10.1182/blood.V122.21.457.457Human CRP Defends against the Toxicity of Circulating Histones (Journal article)
Abrams, S. T., Zhang, N., Dart, C., Wang, S. S., Thachil, J., Guan, Y., . . . Toh, C. -H. (2013). Human CRP Defends against the Toxicity of Circulating Histones. JOURNAL OF IMMUNOLOGY, 191(5), 2495-2502. doi:10.4049/jimmunol.1203181Circulating Histones Are Mediators of Trauma-associated Lung Injury (Journal article)
Abrams, S. T., Zhang, N., Manson, J., Liu, T., Dart, C., Baluwa, F., . . . Toh, C. -H. (2013). Circulating Histones Are Mediators of Trauma-associated Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 187(2), 160-169. doi:10.1164/rccm.201206-1037OCActivated protein C (APC) and thrombin modulate cardiomyocytes contractility via a protease activated receptor-1 (PAR1)-cardiac troponin I (CTI) pathway (Conference Paper)
Alhamdi, Y., Wang, G., & Toh, C. -H. (2013). Activated protein C (APC) and thrombin modulate cardiomyocytes contractility via a protease activated receptor-1 (PAR1)-cardiac troponin I (CTI) pathway. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 38). Retrieved from https://www.webofscience.com/Acute phase proteins reduce histone-induced platelet aggregation and coagulation activation (Conference Paper)
Abrams, S. T., Manson, J., Liu, T., Baluwa, F., Barrera, V., Brohi, K., . . . Toh, C. H. (2013). Acute phase proteins reduce histone-induced platelet aggregation and coagulation activation. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 22). Retrieved from https://www.webofscience.com/Circulating histone-induced thrombosis leads to circulatory and respiratory failure (Conference Paper)
Abrams, S. T., Manson, J., Liu, T., Alhamdi, Y., Brohi, K., Wang, G., & Toh, C. H. (2013). Circulating histone-induced thrombosis leads to circulatory and respiratory failure. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 128). Retrieved from https://www.webofscience.com/Platelet surface high mobility group box protein-1 binds receptor for advanced glycation endproducts in plasma or on monocytes in septic patients (Conference Paper)
Thachil, J., Barrera, V., Djebabri, B., Abrams, S. T., Wang, G., & Toh, C. H. (2013). Platelet surface high mobility group box protein-1 binds receptor for advanced glycation endproducts in plasma or on monocytes in septic patients. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 71). Retrieved from https://www.webofscience.com/The involvement of epigenetic silencing of Foxa2 in cellular replicative and premature senescence induced by hydrogen peroxide. (Journal article)
Zhang, W., Ji, W., Yang, L., Yao, L., Wang, G., Xuan, A., & Zhuang, Z. (2013). The involvement of epigenetic silencing of Foxa2 in cellular replicative and premature senescence induced by hydrogen peroxide.. Free radical research, 47(4), 325-332. doi:10.3109/10715762.2013.7735892012
S100P Dissociates Myosin IIA Filaments and Focal Adhesion Sites to Reduce Cell Adhesion and Enhance Cell Migration (Journal article)
Du, M., Wang, G., Ismail, T. M., Gross, S., Fernig, D. G., Barraclough, R., & Rudland, P. S. (2012). S100P Dissociates Myosin IIA Filaments and Focal Adhesion Sites to Reduce Cell Adhesion and Enhance Cell Migration. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(19), 15330-15344. doi:10.1074/jbc.M112.3497872011
Reduction of circulating histone toxicity is a major function of C-reactive protein after extensive tissue damage (Preprint)
2010
Self-association of Calcium-binding Protein S100A4 and Metastasis (Journal article)
Ismail, T. M., Zhang, S., Fernig, D. G., Gross, S., Martin-Fernandez, M. L., See, V., . . . Barraclough, R. (2010). Self-association of Calcium-binding Protein S100A4 and Metastasis. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(2), 914-922. doi:10.1074/jbc.M109.0108922008
The basic C-terminal amino acids of calcium-binding protein S100A4 promote metastasis (Journal article)
Ismail, T. M., Fernig, D. G., Rudland, P. S., Terry, C. J., Wang, G., & Barraclough, R. (2008). The basic C-terminal amino acids of calcium-binding protein S100A4 promote metastasis. CARCINOGENESIS, 29(12), 2259-2266. doi:10.1093/carcin/bgn217HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions. (Journal article)
Aucott, R., Bullwinkel, J., Yu, Y., Shi, W., Billur, M., Brown, J. P., . . . Singh, P. B. (2008). HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions.. The Journal of cell biology, 183(4), 597-606. doi:10.1083/jcb.2008040412006
Induction of metastasis by S100P in a rat mammary model and its association with poor survival of breast cancer patients (Journal article)
Wang, G. Z., Platt-Higgins, A., Carroll, J., Rudland, S. D., Winstanley, J., Barraclough, R., & Rudland, P. S. (2006). Induction of metastasis by S100P in a rat mammary model and its association with poor survival of breast cancer patients. CANCER RESEARCH, 66(2), 1199-1207. doi:10.1158/0008-5472.CAN-05-26052005
The <i>C</i>-terminal region of S100A4 is important for its metastasis-inducing properties (Journal article)
Zhang, S., Wang, G. Z., Liu, D., Bao, Z. Z., Fernig, D. G., Rudland, P. S., & Barraclough, R. (2005). The <i>C</i>-terminal region of S100A4 is important for its metastasis-inducing properties. ONCOGENE, 24(27), 4401-4411. doi:10.1038/sj.onc.1208663Mutually antagonistic actions of S100A4 and S100A1 on normal and metastatic phenotypes (Journal article)
Wang, G. Z., Zhang, S., Fernig, D. G., Martin-Fernandez, M., Rudland, P. S., & Barraclough, R. (2005). Mutually antagonistic actions of S100A4 and S100A1 on normal and metastatic phenotypes. ONCOGENE, 24(8), 1445-1454. doi:10.1038/sj.onc.1208291Interaction of metastasis-inducing S100A4 protein in vivo by fluorescence lifetime imaging microscopy (Journal article)
Zhang, S., Wang, G. Z., Fernig, D. G., Rudland, P. S., Webb, S. E. D., Barraclough, R., & Martin-Fernandez, M. (2005). Interaction of metastasis-inducing S100A4 protein in vivo by fluorescence lifetime imaging microscopy. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 34(1), 19-27. doi:10.1007/s00249-004-0428-x2004
Heterodimeric interaction and interfaces of S100A1 and S100P (Journal article)
Wang, G. Z., Zhang, S., Fernig, D. G., Spiller, D., Martin-Fernandez, M., Zhang, H. M., . . . Barraclough, R. (2004). Heterodimeric interaction and interfaces of S100A1 and S100P. BIOCHEMICAL JOURNAL, 382, 375-383. doi:10.1042/BJ200401422003
Purification, crystallization and preliminary X-ray analysis of human pirin. (Journal article)
Zeng, Q., Li, X., Bartlam, M., Wang, G., Pang, H., & Rao, Z. (2003). Purification, crystallization and preliminary X-ray analysis of human pirin.. Acta crystallographica. Section D, Biological crystallography, 59(Pt 8), 1496-1498. doi:10.1107/s0907444903012289The crystal structure at 2 Å resolution of the Ca<SUP>2+</SUP>-binding protein S100P (Journal article)
Zhang, H. M., Wang, G. Z., Ding, Y., Wang, Z. L., Barraclough, R., Rudland, P. S., . . . Rao, Z. H. (2003). The crystal structure at 2 Å resolution of the Ca<SUP>2+</SUP>-binding protein S100P. JOURNAL OF MOLECULAR BIOLOGY, 325(4), 785-794. doi:10.1016/S0022-2836(02)01278-02002
Purification, crystallization and preliminary X-ray diffraction studies of a Ca<SUP>2+</SUP>-binding protein, human S100P (Journal article)
Zhang, H. M., Wang, Z. L., Ding, Y., Wang, G. Z., Wang, X. D., Gao, F., . . . Rao, Z. H. (2002). Purification, crystallization and preliminary X-ray diffraction studies of a Ca<SUP>2+</SUP>-binding protein, human S100P. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 58, 694-696. doi:10.1107/S0907444902002342Crystallization and preliminary crystallographic analysis of a metastasis-inducing protein, human S100A4 (Journal article)
Zhang, H. M., Wang, Z. L., Ding, Y., Wang, G. Z., Wang, X. D., Bartlam, M., . . . Rao, Z. H. (2002). Crystallization and preliminary crystallographic analysis of a metastasis-inducing protein, human S100A4. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 58, 127-129. doi:10.1107/S090744490101650X2001
Preliminary X-ray crystallographic analysis of a Ca<SUP>2+</SUP>-binding protein human S100A1 (Journal article)
Wang, Z. L., Zhang, H. M., Ding, Y., Wang, G. Z., Wang, X. D., Ye, S., . . . Rao, Z. H. (2001). Preliminary X-ray crystallographic analysis of a Ca<SUP>2+</SUP>-binding protein human S100A1. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 57, 882-883. doi:10.1107/S09074449010052732000
Conservation of heterochromatin protein 1 function. (Journal article)
Wang, G., Ma, A., Chow, C. M., Horsley, D., Brown, N. R., Cowell, I. G., & Singh, P. B. (2000). Conservation of heterochromatin protein 1 function.. Molecular and cellular biology, 20(18), 6970-6983. doi:10.1128/mcb.20.18.6970-6983.2000Interaction <i>in vivo</i> and <i>in vitro</i> of the metastasis-inducing S100 protein, S100A4 (p9Ka) with S100A1 (Journal article)
Wang, G. Z., Rudland, P. S., White, M. R., & Barraclough, R. (2000). Interaction <i>in vivo</i> and <i>in vitro</i> of the metastasis-inducing S100 protein, S100A4 (p9Ka) with S100A1. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(15), 11141-11146. doi:10.1074/jbc.275.15.111411998
The M31 gene has a complex developmentally regulated expression profile and may encode alternative protein products that possess diverse subcellular localisation patterns. (Journal article)
Peterson, K., Wang, G., Horsley, D., Richardson, J. C., Sapienza, C., Latham, K. E., & Singh, P. B. (1998). The M31 gene has a complex developmentally regulated expression profile and may encode alternative protein products that possess diverse subcellular localisation patterns.. The Journal of experimental zoology, 280(4), 288-303. doi:3.0.co;2-k">10.1002/(sici)1097-010x(19980301)280:4<288::aid-jez3>3.0.co;2-kDOI: 10.1002/(sici)1097-010x(19980301)280:4<288::aid-jez3>3.0.co;2-k