Dr Guozheng Wang MBChB, MD, PhD.

Consultant Clinical Scientist and Honorary Professor Clinical Infection, Microbiology & Immunology

Research

Sepsis and other critical illnesses, pathophysiology, diagnosis, monitoring and therapy

My current interest is mainly in the physiopathology of sepsis to understand molecular mechanisms and develop diagnostic, prognostic and therapeutic tools. In addition, I am also interested in the acute phase response, the transition from infection/inflammation to carcinogenesis and arthrosclerosis. The genetic matching between host and pathogen in septic shock is also within our research scope. Currently, the innate immunity to DAMPs and their roles in sepsis development from localised infection as well as the mechanisms of immunosuppression in critical illnesses become new focuses.

Our laboratory employs basic research tools, including particularly molecular and cellular biology, protein biochemistry flow cytometry, confocal imaging of cells and calcium signals, cardiomyocyte contractions etc, mass spectrometry, including proteomics and phosphoproteomics; animal models, including sepsis, pancreatitis, and trauma mouse or rat models; and clinical studies, including patients enrolled in different Intensive Care Units.

Molecular/immune mechanisms of sepsis development from localised infection in initial stage and emerging immunosuppression in late stage

The roles of Damage-associated molecular patterns (DAMPs) in critical illnesses

Research Grants

Bench Fees for Mohmad Alsabani

ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

November 2016 - October 2020

The mechanisms of extracellular histone-induced immunothrombosis and its roles in microvascular circulatory failure during critical illnesses

BRITISH HEART FOUNDATION (UK)

September 2016 - March 2020

Pilot project for the establishment of a breast cancer-related protein interaction map.

CANCER AND POLIO RESEARCH FUND LTD (UK)

September 2005 - September 2007

Determination of the structure of the complex between S100P and Tubulin and its role in cell migration and metastasis

CANCER AND POLIO RESEARCH FUND LTD (UK)

April 2013 - April 2015

British Society for Haematology

BRITISH SOCIETY FOR HAEMATOLOGY (UK)

January 2014 - December 2014

ISTH XXII Congress International Society on Thrombosis and Haemostasis - Royal Society International Travel Grant application

ROYAL SOCIETY (CHARITABLE)

July 2009

Ishtar Adnan Mohammed Alethari - Bench Fees

REPUBLIC OF IRAQ MINISTRY OF EDUCATION🚩

October 2014 - September 2017

Developing a rapid, robust and comprehensive assay for histones and chromatin breakdown products via xMAP technology

DEPARTMENT OF HEALTH & SOCIAL CARE (UK)

March 2011 - September 2012

The Role of Circulating Histones in the Cardiac Dysfunction of Sepsis.

BRITISH HEART FOUNDATION (UK)

September 2014 - August 2016