2024
Fothergill, J., Kadioglu, A., & Hall, J. (2024). Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo. Nature Communications.
2023
Novel 3D in vitro human placenta-on-a-chip model derived using human trophoblast stem cells differentiated towards syncytiotrophoblasts and extravillous trophoblasts to mimic both villi and implantation sides of the placenta. (Conference Paper)
Radziun, K., Sharp, A., Aye, I., Turner, D., Kadioglu, A., & Yang, M. (2023). Novel 3D in vitro human placenta-on-a-chip model derived using human trophoblast stem cells differentiated towards syncytiotrophoblasts and extravillous trophoblasts to mimic both villi and implantation sides of the placenta.. In Placenta Vol. 140 (pp. e27). Elsevier BV. doi:10.1016/j.placenta.2023.07.101DOI: 10.1016/j.placenta.2023.07.101
NOVEL 3D IN VITRO HUMAN PLACENTA-ON-A-CHIP MODEL DERIVED USING HUMAN TROPHOBLAST STEM CELLS DIFFERENTIATED TOWARDS SYNCYTIOTROPHOBLASTS AND EXTRAVILLOUS TROPHOBLASTS TO MIMIC BOTH VILLI AND IMPLANTATION SIDES OF THE PLACENTA (Conference Paper)
Radziun, K., Sharp, A., Aye, I., Turner, D., Kadioglu, A., & Yang, M. (2023). NOVEL 3D IN VITRO HUMAN PLACENTA-ON-A-CHIP MODEL DERIVED USING HUMAN TROPHOBLAST STEM CELLS DIFFERENTIATED TOWARDS SYNCYTIOTROPHOBLASTS AND EXTRAVILLOUS TROPHOBLASTS TO MIMIC BOTH VILLI AND IMPLANTATION SIDES OF THE PLACENTA. In PLACENTA Vol. 140 (pp. E27-E28). Retrieved from https://www.webofscience.com/
Xu, R., Jacques, L. C., Khandaker, S., Leon-Rios, M., Beentjes, D., Wei, X., . . . Kadioglu, A. (2023). TNFR2<SUP>+</SUP> regulatory T cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing y? T cells in the lung. CELL REPORTS, 42(2). doi:10.1016/j.celrep.2023.112054DOI: 10.1016/j.celrep.2023.112054
Jacques, L. C., Green, A. E., Barton, T. E., Baltazar, M., Aleksandrowicz, J., Xu, R., . . . Neill, D. R. (2022). Influence of Streptococcus pneumoniae Within-Strain Population Diversity on Virulence and Pathogenesis. MICROBIOLOGY SPECTRUM. doi:10.1128/spectrum.03103-22DOI: 10.1128/spectrum.03103-22
2022
Hasan, C. M., Pottenger, S., Green, A. E., Cox, A. A., White, J. S., Jones, T., . . . Fothergill, J. L. (2022). Pseudomonas aeruginosa utilizes the host-derived polyamine spermidine to facilitate antimicrobial tolerance. JCI INSIGHT, 7(22). doi:10.1172/jci.insight.158879DOI: 10.1172/jci.insight.158879
Mechanistic Insights into the Impact of Air Pollution on Pneumococcal Pathogenesis and Transmission (Journal article)
Beentjes, D., Shears, R. K., French, N., Neill, D. R., & Kadioglu, A. (2022). Mechanistic Insights into the Impact of Air Pollution on Pneumococcal Pathogenesis and Transmission. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 206(9), 1070-1080. doi:10.1164/rccm.202112-2668TRDOI: 10.1164/rccm.202112-2668TR
Audshasai, T., Coles, J. A., Panagiotou, S., Khandaker, S., Scales, H. E., Kjos, M., . . . Yang, M. (2022). Streptococcus pneumoniae Rapidly Translocate from the Nasopharynx through the Cribriform Plate to Invade the Outer Meninges. MBIO, 13(4). doi:10.1128/mbio.01024-22DOI: 10.1128/mbio.01024-22
Salgado, B. A. B., Waters, E. M., Moran, J. C., Kadioglu, A., & Horsburgh, M. J. (n.d.). Selection of Staphylococcus aureus in a murine nasopharyngeal colonization model. Frontiers in Cellular and Infection Microbiology, 12. doi:10.3389/fcimb.2022.874138DOI: 10.3389/fcimb.2022.874138
Serotype 1 pneumococcus: epidemiology, genomics, and disease mechanisms (Journal article)
Chaguza, C., Yang, M., Jacques, L. C., Bentley, S. D., & Kadioglu, A. (2022). Serotype 1 pneumococcus: epidemiology, genomics, and disease mechanisms. TRENDS IN MICROBIOLOGY, 30(6), 581-592. doi:10.1016/j.tim.2021.11.007DOI: 10.1016/j.tim.2021.11.007
Wezen, X. C., Chandran, A., Eapen, R. S., Waters, E., Bricio-Moreno, L., Tosi, T., . . . Rahman, T. (2022). Structure-Based Discovery of Lipoteichoic Acid Synthase Inhibitors. JOURNAL OF CHEMICAL INFORMATION AND MODELING, 62(10), 2586-2599. doi:10.1021/acs.jcim.2c00300DOI: 10.1021/acs.jcim.2c00300
Miyashita, L., Shears, R., Foley, G., Semple, S., Kadioglu, A., & Grigg, J. (2022). Underground railway particulate matter and susceptibility to pneumococcal infection. EBIOMEDICINE, 80. doi:10.1016/j.ebiom.2022.104063DOI: 10.1016/j.ebiom.2022.104063
Chaguza, C., Ebruke, C., Senghore, M., Lo, S. W., Tientcheu, P. -E., Gladstone, R. A., . . . Bentley, S. D. (2022). Comparative Genomics of Disease and Carriage Serotype 1 Pneumococci. GENOME BIOLOGY AND EVOLUTION, 14(4). doi:10.1093/gbe/evac052DOI: 10.1093/gbe/evac052
Panagiotou, S., Chaguza, C., Yahya, R., Audshasai, T., Baltazar, M., Ressel, L., . . . Yang, M. (2022). Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity (vol 10, 17313, 2020). SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-08813-wDOI: 10.1038/s41598-022-08813-w
2021
Clarke, J., Baltazar, M., Alsahag, M., Panagiotou, S., Pouget, M., Paxton, W. A., . . . Kadioglu, A. (2021). Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-97866-4DOI: 10.1038/s41598-021-97866-4
Law, A. E., Shears, R. K., Lopez Rodas, A. A., Grencis, R. K., Cooper, P. J., Neill, D. R., & Kadioglu, A. (2021). Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-86508-4DOI: 10.1038/s41598-021-86508-4
Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity (vol 10, 17313, 2020) (Journal article)
Panagiotou, S., Chaguza, C., Yahya, R., Audshasai, T., Baltazar, M., Ressel, L., . . . Yang, M. (2021). Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity (vol 10, 17313, 2020). SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-86214-1DOI: 10.1038/s41598-021-86214-1
2020
Panagiotou, S., Chaguza, C., Yahya, R., Audshasai, T., Baltazar, M., Ressel, L., . . . Yang, M. (2020). Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-73454-wDOI: 10.1038/s41598-020-73454-w
Chaguza, C., Yang, M., Cornick, J. E., du Plessis, M., Gladstone, R. A., Kwambana-Adams, B. A., . . . Bentley, S. D. (2020). Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism. COMMUNICATIONS BIOLOGY, 3(1). doi:10.1038/s42003-020-01290-9DOI: 10.1038/s42003-020-01290-9
Nyazika, T. K., Law, A., Swarthout, T. D., Sibale, L., ter Braake, D., French, N., . . . Neill, D. R. (2020). Influenza-like illness is associated with high pneumococcal carriage density in Malawian children. JOURNAL OF INFECTION, 81(4), 549-556. doi:10.1016/j.jinf.2020.06.079DOI: 10.1016/j.jinf.2020.06.079
IL-35 is critical in suppressing superantigenic <i>Staphylococcus aureus</i>-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue (Journal article)
Xu, R., Shears, R. K., Sharma, R., Krishna, M., Webb, C., Ali, R., . . . Zhang, Q. (2020). IL-35 is critical in suppressing superantigenic <i>Staphylococcus aureus</i>-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue. MUCOSAL IMMUNOLOGY, 13(3), 460-470. doi:10.1038/s41385-019-0246-1DOI: 10.1038/s41385-019-0246-1
Jacques, L. C., Panagiotou, S., Baltazar, M., Senghore, M., Khandaker, S., Xu, R., . . . Kadioglu, A. (2020). Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-15751-6DOI: 10.1038/s41467-020-15751-6
Early Signals of Vaccine-driven Perturbation Seen in Pneumococcal Carriage Population Genomic Data (Journal article)
Chaguza, C., Heinsbroek, E., Gladstone, R., Tafatatha, T., Alaerts, M., Peno, C., . . . Bentley, S. (2020). Early Signals of Vaccine-driven Perturbation Seen in Pneumococcal Carriage Population Genomic Data. Clinical Infectious Diseases, 70(7), 1294-1303. doi:10.1093/cid/ciz404DOI: 10.1093/cid/ciz404
Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease (Journal article)
Shears, R. K., Jacques, L. C., Naylor, G., Miyashita, L., Shadia, K., Lebre, F., . . . Kadioglu, A. (2020). Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease. Journal of Allergy and Clinical Immunology, 145(4), 1272-1284.e6. doi:10.1016/j.jaci.2019.11.039DOI: 10.1016/j.jaci.2019.11.039
Gallagher, L. A., Shears, R. K., Fingleton, C., Alvarez, L., Waters, E. M., Clarke, J., . . . O'Gara, J. P. (2020). Impaired alanine transport or exposure to d-cycloserine increases the susceptibility of MRSA to β-lactam antibiotics.. The Journal of infectious diseases, 221(6), 1000-1016. doi:10.1093/infdis/jiz542DOI: 10.1093/infdis/jiz542
2019
Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival (Journal article)
Subramanian, K., Neill, D. R., Malak, H., Spelmink, L., Khandaker, S., Marchiori, G., . . . Henriques-Normark, B. (2019). Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival. Nature Microbiology, 4(1), 62-70. doi:10.1038/s41564-018-0280-xDOI: 10.1038/s41564-018-0280-x
Pneumolysin interaction with the mannose receptor promotes pneumococcal invasion of the airways by blocking inflammatory responses (Conference Paper)
Subramanian, K., Neill, D. R., Malak, H. A., Spelmink, L., Khandaker, S., Marchiori, G. D. L., . . . Henriques-Normark, B. (2019). Pneumolysin interaction with the mannose receptor promotes pneumococcal invasion of the airways by blocking inflammatory responses. In SCANDINAVIAN JOURNAL OF IMMUNOLOGY Vol. 90. Retrieved from https://www.webofscience.com/
2018
Chaguza, C., Heinsbroek, E., Gladstone, R., Tafatatha, T., Alaerts, M., Peno, C., . . . Bentley, S. (n.d.). Early signals of vaccine driven perturbation seen in pneumococcal carriage population genomic data. BioRxiv. doi:10.1101/459693DOI: 10.1101/459693
Cornick, J. E., Kiran, A. M., Vivancos, R., Van Aartsen, J., Clarke, J., Bevan, E., . . . Everett, D. B. (2018). Epidemiological and Molecula Characterization of an Invasive Group A Streptococcus <i>emm</i>32.2 Outbreak (vol 55, pg 1837, 2017). JOURNAL OF CLINICAL MICROBIOLOGY, 56(9). doi:10.1128/JCM.01001-18DOI: 10.1128/JCM.01001-18
Bricio-Moreno, L., Sheridan, V. H., Goodhead, I., Armstrong, S., Wong, J. K. L., Waters, E. M., . . . Neill, D. R. (2018). Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa. Nature Communications, 9. doi:10.1038/s41467-018-04996-xDOI: 10.1038/s41467-018-04996-x
Francis, V. I., Waters, E. M., Finton-James, S. E., Gori, A., Kadioglu, A., Brown, A. R., & Porter, S. L. (2018). Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-04640-8DOI: 10.1038/s41467-018-04640-8
Graham-Brown, J., Hartley, C., Clough, H., Kadioglu, A., Baylis, M., & Williams, D. J. L. (2018). Erratum for Graham-Brown et al., “Dairy Heifers Naturally Exposed to Fasciola hepatica Develop a Type 2 Immune Response and Concomitant Suppression of Leukocyte Proliferation”. Infection and Immunity, 86(6). doi:10.1128/IAI.00247-18DOI: 10.1128/IAI.00247-18
Miyashita, L., Suri, R., Dearing, E., Mudway, I., Dove, R. E., Neill, D. R., . . . Grigg, J. (2018). E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells. EUROPEAN RESPIRATORY JOURNAL, 51(02), 10 pages. doi:10.1183/13993003.01592-2017DOI: 10.1183/13993003.01592-2017
Dairy heifers naturally exposed to Fasciola hepatica develop a type-2 immune response and concomitant suppression of leukocyte proliferation. (Journal article)
Graham-Brown, J., Hartley, C., Clough, H., Kadioglu, A., Baylis, M., & Williams, D. J. L. (2018). Dairy heifers naturally exposed to Fasciola hepatica develop a type-2 immune response and concomitant suppression of leukocyte proliferation.. Infection and Immunity, 86(1). doi:10.1128/iai.00607-17DOI: 10.1128/iai.00607-17
2017
Bricio-Moreno, L., Ebruke, C., Chaguza, C., Cornick, J., Kwambana-Adams, B., Yang, M., . . . Kadioglu, A. (2017). Comparative genomic analysis and in vivo modelling of Streptococcus pneumoniae ST3081 and ST618 isolates reveal key genetic and phenotypic differences contributing to clonal replacement of serotype 1 in The Gambia.. The Journal of infectious diseases, 216(10), 1318-1327. doi:10.1093/infdis/jix472DOI: 10.1093/infdis/jix472
Chaguza, C., Cornick, J. E., Andam, C. P., Gladstone, R. A., Alaerts, M., Musicha, P., . . . Everett, D. B. (2017). Population genetic structure, antibiotic resistance, capsule switching and evolution of invasive pneumococci before conjugate vaccination in Malawi. VACCINE, 35(35), 4594-4602. doi:10.1016/j.vaccine.2017.07.009DOI: 10.1016/j.vaccine.2017.07.009
Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections (Journal article)
Hassane, M., Demon, D., Soulard, D., Fontaine, J., Keller, L. E., Patin, E. C., . . . Paget, C. (2017). Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections. MUCOSAL IMMUNOLOGY, 10(4), 1056-1068. doi:10.1038/mi.2016.113DOI: 10.1038/mi.2016.113
Bandara, M., Skehel, J. M., Kadioglu, A., Collinson, I., Nobbs, A. H., Blocker, A. J., & Jenkinson, H. F. (2017). The accessory Sec system (SecY2A2) in <i>Streptococcus pneumoniae</i> is involved in export of pneumolysin toxin, adhesion and biofilm formation. MICROBES AND INFECTION, 19(7-8), 402-412. doi:10.1016/j.micinf.2017.04.003DOI: 10.1016/j.micinf.2017.04.003
Waters, E. M., Neill, D. R., Kaman, B., Sahota, J. S., Clokie, M. R. J., Winstanley, C., & Kadioglu, A. (2017). Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa.. Thorax, 72, 666-667. doi:10.1136/thoraxjnl-2016-209265DOI: 10.1136/thoraxjnl-2016-209265
Cornick, J. E., Kiran, A. M., Vivancos, R., Van Aartsen, J., Clarke, J., Bevan, E., . . . Everett, D. B. (n.d.). Epidemiological and Molecular Characterization of an Invasive Group A Streptococcus emm32.2 Outbreak. Journal of Clinical Microbiology, 55(6), 1837-1846. doi:10.1128/JCM.00191-17DOI: 10.1128/JCM.00191-17
Jusot, J. -F., Neill, D. R., Waters, E., Bangert, M., Collins, M., Bricio Moreno, L., . . . Kadioglu, A. (2017). Airborne dust and high temperatures are risk factors for invasive bacterial disease. Journal of Allergy and Clinical Immunology, 139(3), 977-986.E2. doi:10.1016/j.jaci.2016.04.062DOI: 10.1016/j.jaci.2016.04.062
Cornick, J. E., Bishop, O. T., Yalcin, F., Kiran, A. M., Kumwenda, B., Chaguza, C., . . . Consortium, P. (2017). The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1. VACCINE, 35(6), 972-980. doi:10.1016/j.vaccine.2016.12.037DOI: 10.1016/j.vaccine.2016.12.037
NX-AS-401: A QUORUM SENSING INHIBITOR THAT ENHANCES THE EFFECT OF TOBRAMYCIN ON <i>P</i>. <i>AERUGINOSA</i> IN VITRO AND IN VIVO (Conference Paper)
Williams, D., Sykes, L., Bricio-Marino, L., Fothergill, J., Kadioglu, A., Oldham, H., . . . Graz, M. (2017). NX-AS-401: A QUORUM SENSING INHIBITOR THAT ENHANCES THE EFFECT OF TOBRAMYCIN ON <i>P</i>. <i>AERUGINOSA</i> IN VITRO AND IN VIVO. In PEDIATRIC PULMONOLOGY Vol. 52 (pp. S350-S351). Retrieved from https://www.webofscience.com/
Waters, E. M., Rudkin, J. K., Coughlan, S., Clair, G. C., Adkins, J. N., Gore, S., . . . O'Gara, J. P. (2017). Redeploying β-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections. JOURNAL OF INFECTIOUS DISEASES, 215(1), 80-87. doi:10.1093/infdis/jiw461DOI: 10.1093/infdis/jiw461
2016
Chaguza, C., Cornick, J. E., Harris, S. R., Andam, C. P., Bricio-Moreno, L., Yang, M., . . . Bentley, S. D. (2016). Understanding pneumococcal serotype 1 biology through population genomic analysis. BMC INFECTIOUS DISEASES, 16. doi:10.1186/s12879-016-1987-zDOI: 10.1186/s12879-016-1987-z
Chaguza, C., Andam, C. P., Harris, S. R., Cornick, J. E., Yang, M., Bricio-Moreno, L., . . . Hanage, W. P. (2016). Recombination in <i>Streptococcus pneumoniae</i> Lineages Increase with Carriage Duration and Size of the Polysaccharide Capsule. MBIO, 7(5). doi:10.1128/mBio.01053-16DOI: 10.1128/mBio.01053-16
Pneumococcal Biology, Diversity, Evolution and Host Responses to Infection (Chapter)
Neill, D. R., Yang, M., & Kadioglu, A. (2016). Pneumococcal Biology, Diversity, Evolution and Host Responses to Infection. In ENCYCLOPEDIA OF IMMUNOBIOLOGY, VOL 4: IMMUNITY TO PATHOGENS AND TUMORS (pp. 60-65). doi:10.1016/B978-0-12-374279-7.13019-XDOI: 10.1016/B978-0-12-374279-7.13019-X
Alternatives to antibiotics-a pipeline portfolio review (Journal article)
Czaplewski, L., Bax, R., Clokie, M., Dawson, M., Fairhead, H., Fischetti, V. A., . . . Rex, J. H. (2016). Alternatives to antibiotics-a pipeline portfolio review. LANCET INFECTIOUS DISEASES, 16(2), 239-251. doi:10.1016/S1473-3099(15)00466-1DOI: 10.1016/S1473-3099(15)00466-1
Morton, B., Mitsi, E., Pennington, S. H., Reine, J., Wright, A. D., Parker, R., . . . Gordon, S. B. (2016). AUGMENTED PASSIVE IMMUNOTHERAPY WITH P4 PEPTIDE IMPROVES PHAGOCYTE ACTIVITY IN SEVERE SEPSIS. SHOCK, 46(6), 635-641. doi:10.1097/SHK.0000000000000715DOI: 10.1097/SHK.0000000000000715
2015
Bacteriophage Delivery by Nebulization and Efficacy Against Phenotypically Diverse <i>Pseudomonas aeruginosa</i> from Cystic Fibrosis Patients (Journal article)
Sahota, J. S., Smith, C. M., Radhakrishnan, P., Winstanley, C., Goderdzishvili, M., Chanishvili, N., . . . Clokie, M. R. J. (2015). Bacteriophage Delivery by Nebulization and Efficacy Against Phenotypically Diverse <i>Pseudomonas aeruginosa</i> from Cystic Fibrosis Patients. JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 28(5), 353-360. doi:10.1089/jamp.2014.1172DOI: 10.1089/jamp.2014.1172
Ca²⁺-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins. (Journal article)
Wolfmeier, H., Schoenauer, R., Atanassoff, A. P., Neill, D. R., Kadioglu, A., Draeger, A., & Babiychuk, E. B. (2015). Ca²⁺-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins.. Biochimica et biophysica acta, 1853(9), 2045-2054. doi:10.1016/j.bbamcr.2014.09.005DOI: 10.1016/j.bbamcr.2014.09.005
Alhamdi, Y., Neill, D., Abrams, S., Malak, H., Yahya, R., Barrett-Jolley, R., . . . Toh, C. -H. (2015). Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection. PLoS Pathogens, 11(5). doi:10.1371/journal.ppat.1004836DOI: 10.1371/journal.ppat.1004836
Pneumolysin (Chapter)
Neill, D. R., Mitchell, T. J., & Kadioglu, A. (2015). Pneumolysin. In Streptococcus Pneumoniae (pp. 257-275). Elsevier. doi:10.1016/b978-0-12-410530-0.00014-4DOI: 10.1016/b978-0-12-410530-0.00014-4
Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K<SUP>+</SUP> Efflux (Journal article)
Karmakar, M., Katsnelson, M., Malak, H. A., Greene, N. G., Howell, S. J., Hise, A. G., . . . Pearlman, E. (2015). Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K<SUP>+</SUP> Efflux. JOURNAL OF IMMUNOLOGY, 194(4), 1763-1775. doi:10.4049/jimmunol.1401624DOI: 10.4049/jimmunol.1401624
Henry, B. D., Neill, D., Becker, K. A., Gore, S., Bricio Moreno, L., Ziobro, R., . . . Babiychuk, E. B. (2015). Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice. Nature Biotechnology, 33(1), 81-88. doi:10.1038/nbt.3037DOI: 10.1038/nbt.3037
2014
Density and duration of experimental human pneumococcal carriage (Journal article)
Gritzfeld, J. F., Cremers, A. J. H., Ferwerda, G., Ferreira, D. M., Kadioglu, A., Hermans, P. W. M., & Gordon, S. B. (2014). Density and duration of experimental human pneumococcal carriage. CLINICAL MICROBIOLOGY AND INFECTION, 20(12), O1145-O1151. doi:10.1111/1469-0691.12752DOI: 10.1111/1469-0691.12752
Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs. (Journal article)
Fothergill, J. L., Neill, D. R., Loman, N., Winstanley, C., & Kadioglu, A. (2014). Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs.. Nature Communications, 5, 9 pages. doi:10.1038/ncomms5780DOI: 10.1038/ncomms5780
Ca<SUP>2+</SUP>-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins (Journal article)
Wolfmeier, H., Schoenauer, R., Atanassoff, A. P., Neill, D. R., Kadioglu, A., Draeger, A., & Babiychuk, E. B. (2015). Ca<SUP>2+</SUP>-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1853(9), 2045-2054. doi:10.1016/j.bbamcr.2014.09.005DOI: 10.1016/j.bbamcr.2014.09.005
Neill, D. R., Saint, G. L., Bricio-Moreno, L., Fothergill, J., Southern, K. W., Winstanley, C., . . . Flanagan, B. F. (2014). THE B LYMPHOCYTE DIFFERENTIATION FACTOR (BAFF) IS EXPRESSED IN THE AIRWAYS OF CHILDREN WITH CF AND IN LUNGS OF MICE INFECTED WITH PSEUDOMONAS AERUGINOSA. PLoS One, 9(5). doi:10.1371/journal.pone.0095892.DOI: 10.1371/journal.pone.0095892.
Density and duration of pneumococcal carriage is maintained by transforming growth factor β1 and T regulatory cells. (Journal article)
Neill, D., Coward, W. R., Gritzfeld, J., Richards, L., Garcia-Garcia, F. J., Dotor, J., . . . Kadioglu, A. (2014). Density and duration of pneumococcal carriage is maintained by transforming growth factor β1 and T regulatory cells.. American journal of respiratory and critical care medicine, 189(10), 1250-1259. doi:10.1164/rccm.201401-0128OCDOI: 10.1164/rccm.201401-0128OC
<i>Streptococcus pneumoniae</i> detects and responds to foreign bacterial peptide fragments in its environment (Journal article)
Hathaway, L. J., Baettig, P., Reber, S., Rotzetter, J. U., Aebi, S., Hauser, C., . . . Muehlemann, K. (2014). <i>Streptococcus pneumoniae</i> detects and responds to foreign bacterial peptide fragments in its environment. OPEN BIOLOGY, 4(4). doi:10.1098/rsob.130224DOI: 10.1098/rsob.130224
The Pneumococcal Polysaccharide Capsule and Pneumolysin Differentially Affect CXCL8 and IL-6 Release from Cells of the Upper and Lower Respiratory Tract (Journal article)
Kueng, E., Coward, W. R., Neill, D. R., Malak, H. A., Muehlemann, K., Kadioglu, A., . . . Hathaway, L. J. (2014). The Pneumococcal Polysaccharide Capsule and Pneumolysin Differentially Affect CXCL8 and IL-6 Release from Cells of the Upper and Lower Respiratory Tract. PLOS ONE, 9(3). doi:10.1371/journal.pone.0092355DOI: 10.1371/journal.pone.0092355
A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia (Journal article)
De Filippo, K., Neill, D. R., Mathies, M., Bangert, M., McNeill, E., Kadioglu, A., & Hogg, N. (2014). A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia. FASEB JOURNAL, 28(8), 3600-3608. doi:10.1096/fj.13-247460DOI: 10.1096/fj.13-247460
Characterisation of regulatory T cells in human nasopharynx-associated lymphoid tissue (NALT) and relationship with <i>streptococcus pneumoniae</i> (Journal article)
Rider, A., Vaughan, C., Upile, N., Sharma, R., Beer, H., McCormick, M., . . . Zhang, Q. (2014). Characterisation of regulatory T cells in human nasopharynx-associated lymphoid tissue (NALT) and relationship with <i>streptococcus pneumoniae</i>. IMMUNOLOGY, 143, 146. Retrieved from https://www.webofscience.com/
Elucidation of the pathogenesis of pneumococcal meningitis in a nasopharynx-to-meninges translocation mouse model (Journal article)
Yang, M., Engel, H., Clauzier, L., Riley, L., Pottinger, S., Cornick, J., . . . Kadioglu, A. (2014). Elucidation of the pathogenesis of pneumococcal meningitis in a nasopharynx-to-meninges translocation mouse model. IMMUNOLOGY, 143, 165. Retrieved from https://www.webofscience.com/
Septicaemia models using <i>Streptococcus pneumoniae</i> and <i>Listeria monocytogenes</i>: understanding the role of complement properdin (Journal article)
Dupont, A., Mohamed, F., Salehen, N., Glenn, S., Francescut, L., Adib, R., . . . Stover, C. (2014). Septicaemia models using <i>Streptococcus pneumoniae</i> and <i>Listeria monocytogenes</i>: understanding the role of complement properdin. MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 203(4), 257-271. doi:10.1007/s00430-013-0324-zDOI: 10.1007/s00430-013-0324-z
The role of the pneumococcal toxin pneumolysin during nasopharyngeal colonisation (Journal article)
Malak, H. A., Neill, D., & Kadioglu, A. (2014). The role of the pneumococcal toxin pneumolysin during nasopharyngeal colonisation. IMMUNOLOGY, 143, 102. Retrieved from https://www.webofscience.com/
2013
Immunoactivating Peptide P4 Augments Alveolar Macrophage Phagocytosis in Two Diverse Human Populations (Journal article)
Bangert, M., Wright, A. K., Rylance, J., Kelly, M. J., Wright, A. D., Carlone, G. M., . . . Gordon, S. B. (2013). Immunoactivating Peptide P4 Augments Alveolar Macrophage Phagocytosis in Two Diverse Human Populations. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 57(9), 4566-4569. doi:10.1128/AAC.00742-13DOI: 10.1128/AAC.00742-13
Distribution sampling and linear modelling for the analysis and validation of worm egg count methods in the diagnosis of <i>Fasciola hepatica</i> (Journal article)
Graham-Brown, J. J. D., Swales, H., Van, D. J., Kadioglu, A., Baylis, M., & Williams, D. J. L. (2013). Distribution sampling and linear modelling for the analysis and validation of worm egg count methods in the diagnosis of <i>Fasciola hepatica</i>. CATTLE PRACTICE, 21, 89. Retrieved from https://www.webofscience.com/
Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B (Journal article)
Neill, D. R., Smeaton, S., Bangert, M., & Kadioglu, A. (2013). Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B. Journal of Allergy and Clinical Immunology, 131(5), 1433-1435.e1. doi:10.1016/j.jaci.2012.11.004DOI: 10.1016/j.jaci.2012.11.004
The AgI/II Family Adhesin AspA Is Required for Respiratory Infection by <i>Streptococcus pyogenes</i> (Journal article)
Franklin, L., Nobbs, A. H., Bricio-Moreno, L., Wright, C. J., Maddocks, S. E., Sahota, J. S., . . . Kadioglu, A. (2013). The AgI/II Family Adhesin AspA Is Required for Respiratory Infection by <i>Streptococcus pyogenes</i>. PLOS ONE, 8(4). doi:10.1371/journal.pone.0062433DOI: 10.1371/journal.pone.0062433
Controlled Human Infection and Rechallenge with Streptococcus pneumoniae Reveals the Protective Efficacy of Carriage in Healthy Adults (Journal article)
Ferreira, D. M., Neill, D. R., Bangert, M., Gritzfeld, J. F., Green, N., Wright, A. K. A., . . . Gordon, S. B. (2013). Controlled Human Infection and Rechallenge with Streptococcus pneumoniae Reveals the Protective Efficacy of Carriage in Healthy Adults. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 187(8), 855-864. doi:10.1164/rccm.201212-2277OCDOI: 10.1164/rccm.201212-2277OC
<i>Spir2</i>; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice (Journal article)
Wisby, L., Fernandes, V. E., Neill, D. R., Kadioglu, A., Andrew, P. W., & Denny, P. (2013). <i>Spir2</i>; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice. BMC GENOMICS, 14. doi:10.1186/1471-2164-14-242DOI: 10.1186/1471-2164-14-242
Experimental Human Pneumococcal Carriage (Journal article)
Gritzfeld, J. F., Wright, A. D., Collins, A. M., Pennington, S. H., Wright, A. K. A., Kadioglu, A., . . . Gordon, S. B. (2013). Experimental Human Pneumococcal Carriage. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (72). doi:10.3791/50115DOI: 10.3791/50115
Induction of T regulatory cells by streptococcus pneumonia (Conference Paper)
Rider, A., Mubarak, A., Derbyshire, S., McNamara, P., Kadioglu, A., & Zhang, Q. (2013). Induction of T regulatory cells by streptococcus pneumonia. In IMMUNOLOGY Vol. 140 (pp. 151). Retrieved from https://www.webofscience.com/
Nasopharyngeal carriage with <i>Streptococcus pneumoniae</i> augments the immunizing effect of pneumolysin toxoid B (Journal article)
Neill, D. R., Smeaton, S., Bangert, M., & Kadioglu, A. (2013). Nasopharyngeal carriage with <i>Streptococcus pneumoniae</i> augments the immunizing effect of pneumolysin toxoid B. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131(5), 1433-+. doi:10.1016/j.jaci.2012.11.004DOI: 10.1016/j.jaci.2012.11.004
Novel approach towards the development of vaccine candidates against pneumococcal meningitis (Conference Paper)
Yang, M., Engel, H., Chaguza, C., Cornick, J., Hathaway, L., Everett, D., & Kadioglu, A. (2013). Novel approach towards the development of vaccine candidates against pneumococcal meningitis. In IMMUNOLOGY Vol. 140 (pp. 201). Retrieved from https://www.webofscience.com/
Novel treatment for bacterial sepsis - augmented passive immunotherapy (Conference Paper)
Gore, S., Bangert, M., Rajam, G., Ades, E. W., Gordon, S. B., & Kadioglu, A. (2013). Novel treatment for bacterial sepsis - augmented passive immunotherapy. In IMMUNOLOGY Vol. 140 (pp. 201). Retrieved from https://www.webofscience.com/
TGFb and T regulatory cells mediate nasopharyngeal carriage of Streptococcus pneumoniae (Conference Paper)
Neill, D. R., Coward, W. R., Gritzfeld, J. F., Richards, L., Gordon, S. B., & Kadioglu, A. (2013). TGFb and T regulatory cells mediate nasopharyngeal carriage of Streptococcus pneumoniae. In IMMUNOLOGY Vol. 140 (pp. 101). Retrieved from https://www.webofscience.com/
2012
Nicotinamide nucleotide transhydrogenase (NNT) acts as a novel modulator of macrophage inflammatory responses (Journal article)
Ripoll, V. M., Meadows, N. A., Bangert, M., Lee, A. W., Kadioglu, A., & Cox, R. D. (2012). Nicotinamide nucleotide transhydrogenase (NNT) acts as a novel modulator of macrophage inflammatory responses. FASEB JOURNAL, 26(8), 3550-3562. doi:10.1096/fj.11-199935DOI: 10.1096/fj.11-199935
Pneumococcal neuraminidase A: an essential upper airway colonization factor for Streptococcus pneumoniae (Journal article)
Brittan, J. L., Buckeridge, T. J., Finn, A., Kadioglu, A., & Jenkinson, H. F. (2012). Pneumococcal neuraminidase A: an essential upper airway colonization factor for Streptococcus pneumoniae. MOLECULAR ORAL MICROBIOLOGY, 27(4), 270-283. doi:10.1111/j.2041-1014.2012.00658.xDOI: 10.1111/j.2041-1014.2012.00658.x
The Lectin Pathway of Complement Activation Is a Critical Component of the Innate Immune Response to Pneumococcal Infection (Journal article)
Ali, Y. M., Lynch, N. J., Haleem, K. S., Fujita, T., Endo, Y., Hansen, S., . . . Schwaeble, W. J. (2012). The Lectin Pathway of Complement Activation Is a Critical Component of the Innate Immune Response to Pneumococcal Infection. PLOS PATHOGENS, 8(7). doi:10.1371/journal.ppat.1002793DOI: 10.1371/journal.ppat.1002793
Death Is Associated with Complement C3 Depletion in Cerebrospinal Fluid of Patients with Pneumococcal Meningitis (Journal article)
Goonetilleke, U. R., Scarborough, M., Ward, S. A., Hussain, S., Kadioglu, A., & Gordon, S. B. (2012). Death Is Associated with Complement C3 Depletion in Cerebrospinal Fluid of Patients with Pneumococcal Meningitis. MBIO, 3(2). doi:10.1128/mBio.00272-11DOI: 10.1128/mBio.00272-11
Lower Density and Shorter Duration of Nasopharyngeal Carriage by Pneumococcal Serotype 1 (ST217) May Explain Its Increased Invasiveness over Other Serotypes. (Journal article)
Bricio-Moreno, L., Chaguza, C., Yahya, R., Shears, R. K., Cornick, J. E., Hokamp, K., . . . Kadioglu, A. (2012). Lower Density and Shorter Duration of Nasopharyngeal Carriage by Pneumococcal Serotype 1 (ST217) May Explain Its Increased Invasiveness over Other Serotypes.. mBio, 11(6). doi:10.1093/infdis/jis223DOI: 10.1093/infdis/jis223
P4-Mediated Antibody Therapy in an Acute Model of Invasive Pneumococcal Disease (Journal article)
Bangert, M., Bricio-Moreno, L., Gore, S., Rajam, G., Ades, E. W., Gordon, S. B., & Kadioglu, A. (2012). P4-Mediated Antibody Therapy in an Acute Model of Invasive Pneumococcal Disease. JOURNAL OF INFECTIOUS DISEASES, 205(9), 1399-1407. doi:10.1093/infdis/jis223DOI: 10.1093/infdis/jis223
T Regulatory Cells Control Susceptibility to Invasive Pneumococcal Pneumonia in Mice (Journal article)
Neill, D. R., Fernandes, V. E., Wisby, L., Haynes, A. R., Ferreira, D. M., Laher, A., . . . Andrew, P. W. (2012). T Regulatory Cells Control Susceptibility to Invasive Pneumococcal Pneumonia in Mice. PLOS PATHOGENS, 8(4). doi:10.1371/journal.ppat.1002660DOI: 10.1371/journal.ppat.1002660
Capsule Type of <i>Streptococcus pneumoniae</i> Determines Growth Phenotype (Journal article)
Hathaway, L. J., Brugger, S. D., Morand, B., Bangert, M., Rotzetter, J. U., Hauser, C., . . . Muehlemann, K. (2012). Capsule Type of <i>Streptococcus pneumoniae</i> Determines Growth Phenotype. PLOS PATHOGENS, 8(3). doi:10.1371/journal.ppat.1002574DOI: 10.1371/journal.ppat.1002574
Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients With Pneumococcal Meningitis Is Associated With Mortality (Journal article)
Wall, E. C., Gordon, S. B., Hussain, S., Goonetilleke, U. R. S., Gritzfeld, J., Scarborough, M., & Kadioglu, A. (2012). Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients With Pneumococcal Meningitis Is Associated With Mortality. CLINICAL INFECTIOUS DISEASES, 54(5), 701-705. doi:10.1093/cid/cir926DOI: 10.1093/cid/cir926
Absence of the lectin activation pathway of complement does not increase susceptibility to <i>Pseudomonas aeruginosa</i> infections (Journal article)
Kenawy, H. I., Ali, Y. M., Rajakumar, K., Lynch, N. J., Kadioglu, A., Stover, C. M., & Schwaeble, W. J. (2012). Absence of the lectin activation pathway of complement does not increase susceptibility to <i>Pseudomonas aeruginosa</i> infections. IMMUNOBIOLOGY, 217(2), 272-280. doi:10.1016/j.imbio.2011.10.001DOI: 10.1016/j.imbio.2011.10.001
2011
Sex-Based Differences in Susceptibility to Respiratory and Systemic Pneumococcal Disease in Mice (Journal article)
Kadioglu, A., Cuppone, A. M., Trappetti, C., List, T., Spreafico, A., Pozzi, G., . . . Oggioni, M. R. (2011). Sex-Based Differences in Susceptibility to Respiratory and Systemic Pneumococcal Disease in Mice. JOURNAL OF INFECTIOUS DISEASES, 204(12), 1971-1979. doi:10.1093/infdis/jir657DOI: 10.1093/infdis/jir657
<i>Streptococcus pyogenes</i> antigen I/II-family polypeptide AspA shows differential ligand-binding properties and mediates biofilm formation (Journal article)
Maddocks, S. E., Wright, C. J., Nobbs, A. H., Brittan, J. L., Franklin, L., Stromberg, N., . . . Jenkinson, H. F. (2011). <i>Streptococcus pyogenes</i> antigen I/II-family polypeptide AspA shows differential ligand-binding properties and mediates biofilm formation. MOLECULAR MICROBIOLOGY, 81(4), 1034-1049. doi:10.1111/j.1365-2958.2011.07749.xDOI: 10.1111/j.1365-2958.2011.07749.x
Gene expression in fungi (Journal article)
Kalkanci, A., Kadioglu, A., Wilson, D., & Jacobsen, M. D. (2011). Gene expression in fungi. IMA FUNGUS, 2(1), 29-32. doi:10.5598/imafungus.2011.02.01.05DOI: 10.5598/imafungus.2011.02.01.05
The Integrins Mac-1 and α<sub>4</sub>β<sub>1</sub> Perform Crucial Roles in Neutrophil and T Cell Recruitment to Lungs during <i>Streptococcus pneumoniae</i> Infection (Journal article)
Kadioglu, A., De Filippo, K., Bangert, M., Fernandes, V. E., Richards, L., Jones, K., . . . Hogg, N. (2011). The Integrins Mac-1 and α<sub>4</sub>β<sub>1</sub> Perform Crucial Roles in Neutrophil and T Cell Recruitment to Lungs during <i>Streptococcus pneumoniae</i> Infection. JOURNAL OF IMMUNOLOGY, 186(10), 5907-5915. doi:10.4049/jimmunol.1001533DOI: 10.4049/jimmunol.1001533
2010
Invasive <i>Streptococcus pneumoniae</i> trigger platelet activation via Toll-like receptor 2 (Journal article)
Keane, C., Tilley, D., Cunningham, A., Smolenski, A., Kadioglu, A., Cox, D., . . . Kerrigan, S. W. (2010). Invasive <i>Streptococcus pneumoniae</i> trigger platelet activation via Toll-like receptor 2. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 8(12), 2757-2765. doi:10.1111/j.1538-7836.2010.04093.xDOI: 10.1111/j.1538-7836.2010.04093.x
McNeela, E. A., Burke, A., Neill, D. R., Baxter, C., Fernandes, V. E., Ferreira, D., . . . Lavelle, E. C. (2010). Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4. PLOS PATHOGENS, 6(11). doi:10.1371/journal.ppat.1001191DOI: 10.1371/journal.ppat.1001191
A Subtype of a <i>Pseudomonas aeruginosa</i> Cystic Fibrosis Epidemic Strain Exhibits Enhanced Virulence in a Murine Model of Acute Respiratory Infection (Journal article)
Carter, M. E. K., Fothergill, J. L., Walshaw, M. J., Rajakumar, K., Kadioglu, A., & Winstanley, C. (2010). A Subtype of a <i>Pseudomonas aeruginosa</i> Cystic Fibrosis Epidemic Strain Exhibits Enhanced Virulence in a Murine Model of Acute Respiratory Infection. JOURNAL OF INFECTIOUS DISEASES, 202(6), 935-942. doi:10.1086/655781DOI: 10.1086/655781
Human Lung Mast Cells Mediate Pneumococcal Cell Death in Response to Activation by Pneumolysin (Journal article)
Cruse, G., Fernandes, V. E., de Salort, J., Pankhania, D., Marinas, M. S., Brewin, H., . . . Kadioglu, A. (2010). Human Lung Mast Cells Mediate Pneumococcal Cell Death in Response to Activation by Pneumolysin. JOURNAL OF IMMUNOLOGY, 184(12), 7108-7115. doi:10.4049/jimmunol.0900802DOI: 10.4049/jimmunol.0900802
Pathogenicity Islands PAPI-1 and PAPI-2 Contribute Individually and Synergistically to the Virulence of <i>Pseudomonas aeruginosa</i> Strain PA14 (Journal article)
Harrison, E. M., Carter, M. E. K., Luck, S., Ou, H. -Y., He, X., Deng, Z., . . . Rajakumar, K. (2010). Pathogenicity Islands PAPI-1 and PAPI-2 Contribute Individually and Synergistically to the Virulence of <i>Pseudomonas aeruginosa</i> Strain PA14. INFECTION AND IMMUNITY, 78(4), 1437-1446. doi:10.1128/IAI.00621-09DOI: 10.1128/IAI.00621-09
The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease (Journal article)
Richards, L., Ferreira, D. M., Miyaji, E. N., Andrew, P. W., & Kadioglu, A. (2010). The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease. IMMUNOBIOLOGY, 215(4), 251-263. doi:10.1016/j.imbio.2009.12.004DOI: 10.1016/j.imbio.2009.12.004
Pneumococcal protein PavA is important for nasopharyngeal carriage and development of sepsis (Journal article)
Kadioglu, A., Brewin, H., Haertel, T., Brittan, J. L., Klein, M., Hammerschmidt, S., & Jenkinson, H. F. (2010). Pneumococcal protein PavA is important for nasopharyngeal carriage and development of sepsis. MOLECULAR ORAL MICROBIOLOGY, 25(1), 50-60. doi:10.1111/j.2041-1014.2009.00561.xDOI: 10.1111/j.2041-1014.2009.00561.x
2009
Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to <i>Streptococcus pneumoniae</i> (Journal article)
Ripoll, V. M., Kadioglu, A., Cox, R., Hume, D. A., & Denny, P. (2010). Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to <i>Streptococcus pneumoniae</i>. JOURNAL OF LEUKOCYTE BIOLOGY, 87(4), 735-741. doi:10.1189/jlb.0509359DOI: 10.1189/jlb.0509359
Sialic Acid: A Preventable Signal for Pneumococcal Biofilm Formation, Colonization, and Invasion of the Host (Journal article)
Trappetti, C., Kadioglu, A., Carter, M., Hayre, J., Iannelli, F., Pozzi, G., . . . Oggioni, M. R. (2009). Sialic Acid: A Preventable Signal for Pneumococcal Biofilm Formation, Colonization, and Invasion of the Host. JOURNAL OF INFECTIOUS DISEASES, 199(10), 1497-1505. doi:10.1086/598483DOI: 10.1086/598483
2008
Increased TNF expression in CD43<SUP>++</SUP> murine blood monocytes (Journal article)
Burke, B., Ahmad, R., Staples, K. J., Snowden, R., Kadioglu, A., Frankenberger, M., . . . Ziegler-Heitbrock, L. (2008). Increased TNF expression in CD43<SUP>++</SUP> murine blood monocytes. IMMUNOLOGY LETTERS, 118(2), 142-147. doi:10.1016/j.imlet.2008.03.012DOI: 10.1016/j.imlet.2008.03.012
The role of <i>Streptococcus pneumoniae</i> virulence factors in host respiratory colonization and disease (Journal article)
Kadioglu, A., Weiser, J. N., Paton, J. C., & Andrew, P. W. (2008). The role of <i>Streptococcus pneumoniae</i> virulence factors in host respiratory colonization and disease. NATURE REVIEWS MICROBIOLOGY, 6(4), 288-301. doi:10.1038/nrmicro1871DOI: 10.1038/nrmicro1871
The ability to utilize mucin affects the regulation of virulence gene expression in <i>Streptococcus pneumoniae</i> (Journal article)
Yesilkaya, H., Manco, S., Kadioglu, A., Terra, V. S., & Andrew, P. W. (2008). The ability to utilize mucin affects the regulation of virulence gene expression in <i>Streptococcus pneumoniae</i>. FEMS MICROBIOLOGY LETTERS, 278(2), 231-235. doi:10.1111/j.1574-6968.2007.01003.xDOI: 10.1111/j.1574-6968.2007.01003.x
2007
MobilomeFINDER:: web-based tools for <i>in silico</i> and experimental discovery of bacterial genomic islands (Journal article)
Ou, H. -Y., He, X., Harrison, E. M., Kulasekara, B. R., Bin Thani, A., Kadioglu, A., . . . Rajakumar, K. (2007). MobilomeFINDER:: web-based tools for <i>in silico</i> and experimental discovery of bacterial genomic islands. NUCLEIC ACIDS RESEARCH, 35, W97-W104. doi:10.1093/nar/gkm380DOI: 10.1093/nar/gkm380
2006
The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo (Journal article)
Lawrence, C. P., Kadioglu, A., Yang, A. -L., Coward, W. R., & Chow, S. C. (2006). The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo. JOURNAL OF IMMUNOLOGY, 177(6), 3827-3836. doi:10.4049/jimmunol.177.6.3827DOI: 10.4049/jimmunol.177.6.3827
Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis (Journal article)
Oggioni, M. R., Trappetti, C., Kadioglu, A., Cassone, M., Iannelli, F., Ricci, S., . . . Pozzi, G. (2006). Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis. MOLECULAR MICROBIOLOGY, 61(5), 1196-1210. doi:10.1111/j.1365-2958.2006.05310.xDOI: 10.1111/j.1365-2958.2006.05310.x
Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis (Journal article)
Manco, S., Hernon, F., Yesilkaya, H., Paton, J. C., Andrew, P. W., & Kadioglu, A. (2006). Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis. INFECTION AND IMMUNITY, 74(7), 4014-4020. doi:10.1128/IAI.01237-05DOI: 10.1128/IAI.01237-05
2005
The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia (Journal article)
Jounblat, R., Clark, H., Eggleton, P., Hawgood, S., Andrew, P. W., & Kadioglu, A. (2005). The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia. RESPIRATORY RESEARCH, 6. doi:10.1186/1465-9921-6-126DOI: 10.1186/1465-9921-6-126
Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts. (Journal article)
Kerr, A. R., Kirkham, L. A. S., Kadioglu, A., Andrew, P. W., Garside, P., Thompson, H., & Mitchell, T. J. (2005). Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts.. Microbes and infection, 7(5-6), 845-852. doi:10.1016/j.micinf.2005.02.011DOI: 10.1016/j.micinf.2005.02.011
Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts (Journal article)
Kerr, A. R., Kirkham, L. A. S., Kadioglu, A., Andrew, P. W., Garside, P., Thompson, H., & Mitchell, T. J. (2005). Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts. MICROBES AND INFECTION, 7(5-6), 845-852. doi:10.1016/j.micinf.2005.02.011DOI: 10.1016/j.micinf.2005.02.011
Susceptibility and resistance to pneumococcal disease in mice. (Journal article)
Kadioglu, A., & Andrew, P. W. (2005). Susceptibility and resistance to pneumococcal disease in mice.. Briefings in functional genomics & proteomics, 4(3), 241-247. doi:10.1093/bfgp/4.3.241DOI: 10.1093/bfgp/4.3.241
2004
The role of pneumolysin in pneumococcal pneumonia and meningitis (Journal article)
Hirst, R. A., Kadioglu, A., O'Callaghan, C., & Andrew, P. W. (2004). The role of pneumolysin in pneumococcal pneumonia and meningitis. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 138(2), 195-201. doi:10.1111/j.1365-2249.2004.02611.xDOI: 10.1111/j.1365-2249.2004.02611.x
CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection (Journal article)
Kadioglu, A., Coward, W., Colston, M. J., Hewitt, C. R. A., & Andrew, P. W. (2004). CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection. INFECTION AND IMMUNITY, 72(5), 2689-2697. doi:10.1128/IAI.72.5.2689-2697.2004DOI: 10.1128/IAI.72.5.2689-2697.2004
Protein serine/threonine kinase StkP positively controls virulence and competence in <i>Streptococcus pneumoniae</i> (Journal article)
Echenique, J., Kadioglu, A., Romao, S., Andrew, P. W., & Trombe, M. C. (2004). Protein serine/threonine kinase StkP positively controls virulence and competence in <i>Streptococcus pneumoniae</i>. INFECTION AND IMMUNITY, 72(4), 2434-2437. doi:10.1128/IAI.72.4.2434-2437.2004DOI: 10.1128/IAI.72.4.2434-2437.2004
Binding and agglutination of <i>Streptococcus pneumoniae</i> by human surfactant protein D (SP-D) vary between strains but, SP-D fails to enhance killing by neutrophils (Journal article)
Jounblat, R., Kadioglu, A., Iannelli, F., Pozzi, G., Eggleton, P., & Andrew, P. W. (2004). Binding and agglutination of <i>Streptococcus pneumoniae</i> by human surfactant protein D (SP-D) vary between strains but, SP-D fails to enhance killing by neutrophils. INFECTION AND IMMUNITY, 72(2), 709-716. doi:10.1128/IAI.72.2.709-716.2004DOI: 10.1128/IAI.72.2.709-716.2004
The innate immune response to pneumococcal lung infection: the untold story (Journal article)
Kadioglu, A., & Andrew, P. W. (2004). The innate immune response to pneumococcal lung infection: the untold story. TRENDS IN IMMUNOLOGY, 25(3), 143-149. doi:10.1016/j.it.2003.12.006DOI: 10.1016/j.it.2003.12.006
2003
Pneumococcal Behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin (vol 71, pg 1813, 2003) (Journal article)
Jounblat, R., Kadioglu, A., Mitchell, T. J., & Andrew, P. W. (2003). Pneumococcal Behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin (vol 71, pg 1813, 2003). INFECTION AND IMMUNITY, 71(12), 7239. doi:10.1128/IAI.71.12.7239.2003DOI: 10.1128/IAI.71.12.7239.2003
The MicAB two-component signaling system is involved in virulence of <i>Streptococcus pneumoniae</i> (Journal article)
Kadioglu, A., Echenique, J., Manco, S., Trombe, M. C., & Andrew, P. W. (2003). The MicAB two-component signaling system is involved in virulence of <i>Streptococcus pneumoniae</i>. INFECTION AND IMMUNITY, 71(11), 6676-6679. doi:10.1128/IAI.71.11.6676-6679.2003DOI: 10.1128/IAI.71.11.6676-6679.2003
Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the ctolytic and complement-activating activities of pneumolysin (Journal article)
Jounblat, R., Kadioglu, A., Mitchell, T. J., & Andrew, P. W. (2003). Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the ctolytic and complement-activating activities of pneumolysin. INFECTION AND IMMUNITY, 71(4), 1813-1819. doi:10.1128/IAI.71.4.1813-1819.2003DOI: 10.1128/IAI.71.4.1813-1819.2003
2002
Upper and lower respiratory tract infection by <i>Streptococcus pneumoniae</i> is affected by pneumolysin deficiency and differences in capsule type (Journal article)
Kadioglu, A., Taylor, S., Iannelli, F., Pozzi, G., Mitchell, T. J., & Andrew, P. W. (2002). Upper and lower respiratory tract infection by <i>Streptococcus pneumoniae</i> is affected by pneumolysin deficiency and differences in capsule type. INFECTION AND IMMUNITY, 70(6), 2886-2890. doi:10.1128/IAI.70.6.2886-2890.2002DOI: 10.1128/IAI.70.6.2886-2890.2002
Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection (Journal article)
Kerr, A. R., Irvine, J. J., Search, J. J., Gingles, N. A., Kadioglu, A., Andrew, P. W., . . . Mitchell, T. J. (2002). Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection. INFECTION AND IMMUNITY, 70(3), 1547-1557. doi:10.1128/IAI.70.3.1547-1557.2002DOI: 10.1128/IAI.70.3.1547-1557.2002
2001
Role of genetic resistance in invasive pneumococcal infection: Identification and study of susceptibility and resistance in inbred mouse strains (Journal article)
Gingles, N. A., Alexander, J. E., Kadioglu, A., Andrew, P. W., Kerr, A., Mitchell, T. J., . . . McPheat, W. L. (2001). Role of genetic resistance in invasive pneumococcal infection: Identification and study of susceptibility and resistance in inbred mouse strains. INFECTION AND IMMUNITY, 69(1), 426-434. doi:10.1128/IAI.69.1.426-434.2001DOI: 10.1128/IAI.69.1.426-434.2001
Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo (Journal article)
Kadioglu, A., Sharpe, J. A., Lazou, I., Svanborg, C., Ockleford, C., Mitchell, T. J., & Andrew, P. W. (2001). Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo. FEMS MICROBIOLOGY LETTERS, 194(1), 105-110. doi:10.1111/j.1574-6968.2001.tb09454.xDOI: 10.1111/j.1574-6968.2001.tb09454.x
Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo (Journal article)
Kadioglu, A. (2001). Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo. FEMS Microbiology Letters, 194(1), 105-110. doi:10.1016/s0378-1097(00)00497-3DOI: 10.1016/s0378-1097(00)00497-3
2000
Role of manganese-containing superoxide dismutase in oxidative stress and virulence of <i>Streptococcus pneumoniae</i> (Journal article)
Yesilkaya, H., Kadioglu, A., Gingles, N., Alexander, J. E., Mitchell, T. J., & Andrew, P. W. (2000). Role of manganese-containing superoxide dismutase in oxidative stress and virulence of <i>Streptococcus pneumoniae</i>. INFECTION AND IMMUNITY, 68(5), 2819-2826. doi:10.1128/IAI.68.5.2819-2826.2000DOI: 10.1128/IAI.68.5.2819-2826.2000
Host cellular immune response to pneumococcal lung infection in mice (Journal article)
Kadioglu, A., Gingles, N. A., Grattan, K., Kerr, A., Mitchell, T. J., & Andrew, P. W. (2000). Host cellular immune response to pneumococcal lung infection in mice. INFECTION AND IMMUNITY, 68(2), 492-501. doi:10.1128/IAI.68.2.492-501.2000DOI: 10.1128/IAI.68.2.492-501.2000
Host cellular immune response to pneumococcal lung infection in mice (vol 68, pg 492, 2000) (Journal article)
Kadioglu, A., Gingles, N. A., Grattan, K., Kerr, A., Mitchell, T. J., & Andrew, P. W. (2000). Host cellular immune response to pneumococcal lung infection in mice (vol 68, pg 492, 2000). INFECTION AND IMMUNITY, 68(4), 2390. doi:10.1128/IAI.68.4.2390-2390.2000DOI: 10.1128/IAI.68.4.2390-2390.2000
1998
Steroid pulse therapy for rheumatoid arthritis: Effect on lymphocyte subsets and mononuclear cell adhesion (Journal article)
Kadioglu, A., & Sheldon, P. (1998). Steroid pulse therapy for rheumatoid arthritis: Effect on lymphocyte subsets and mononuclear cell adhesion. BRITISH JOURNAL OF RHEUMATOLOGY, 37(3), 282-286. Retrieved from https://www.webofscience.com/
1996
Adhesion of rheumatoid lymphocytes to mucosal endothelium: The gut revisited (Journal article)
Kadioglu, A., & Sheldon, P. (1996). Adhesion of rheumatoid lymphocytes to mucosal endothelium: The gut revisited. BRITISH JOURNAL OF RHEUMATOLOGY, 35(3), 218-225. Retrieved from https://www.webofscience.com/
1995
Adherence of porcine Peyer's patch, peripheral blood and lymph node lymphocytes to Peyer's patch lamina propria (Journal article)
KADIOGLU, A., & SHELDON, P. (1995). Adherence of porcine Peyer's patch, peripheral blood and lymph node lymphocytes to Peyer's patch lamina propria. ADVANCES IN MUCOSAL IMMUNOLOGY, PTS A AND B, 371, 81-83. Retrieved from https://www.webofscience.com/
Adherence of rheumatoid lymphocytes to endothelium of lamina propria (Journal article)
KADIOGLU, A., & SHELDON, P. (1995). Adherence of rheumatoid lymphocytes to endothelium of lamina propria. ADVANCES IN MUCOSAL IMMUNOLOGY, PTS A AND B, 371, 171-173. Retrieved from https://www.webofscience.com/
1993
1992
ADHESION OF PERIPHERAL-BLOOD LYMPHOCYTES TO HIGH ENDOTHELIAL VENULES OF GUT MUCOSA - REPLY (Journal article)
SHELDON, P., & KADIOGLU, A. (1992). ADHESION OF PERIPHERAL-BLOOD LYMPHOCYTES TO HIGH ENDOTHELIAL VENULES OF GUT MUCOSA - REPLY. ANNALS OF THE RHEUMATIC DISEASES, 51(7), 926. doi:10.1136/ard.51.7.926-bDOI: 10.1136/ard.51.7.926-b
ADHESION OF RHEUMATOID PERIPHERAL-BLOOD AND SYNOVIAL-FLUID MONONUCLEAR-CELLS TO HIGH ENDOTHELIAL VENULES OF GUT MUCOSA (Journal article)
KADIOGLU, A., & SHELDON, P. (1992). ADHESION OF RHEUMATOID PERIPHERAL-BLOOD AND SYNOVIAL-FLUID MONONUCLEAR-CELLS TO HIGH ENDOTHELIAL VENULES OF GUT MUCOSA. ANNALS OF THE RHEUMATIC DISEASES, 51(1), 126-127. doi:10.1136/ard.51.1.126DOI: 10.1136/ard.51.1.126
