2021
Gale, C., Dorling, J., Arch, B., Woolfall, K., Deja, E., Roper, L., . . . Tume, L. (2021). Optimal outcome measures for a trial of not routinely measuring gastric residual volume in neonatal care: a mixed methods consensus process. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 106(3), F292-F297. doi:10.1136/archdischild-2020-319469DOI: 10.1136/archdischild-2020-319469
Brogan, P. A., Arch, B., Hickey, H., Anton, J., Iglesias, E., Baildam, E., . . . Eleftheriou, D. (2021). Mycophenolate mofetil versus cyclophosphamide for remission induction in childhood polyarteritis nodosa: An open label, randomised, Bayesian, non-inferiority trial.. Arthritis & rheumatology (Hoboken, N.J.). doi:10.1002/art.41730DOI: 10.1002/art.41730
Is a trial of no routine gastric residual volume monitoring to guide enteral feeding is possible in uk picus and nicus? (Conference Paper)
Tume, L., Woolfall, K., Deja, E., Roper, L., Valla, F., Gale, C., . . . Dorling, J. (n.d.). Is a trial of no routine gastric residual volume monitoring to guide enteral feeding is possible in uk picus and nicus?. In Pediatric Critical Care Medicine.
Roper, L., Lyttle, M. D., Gamble, C., Humphreys, A., Messahel, S., Lee, E. D., . . . Woolfall, K. (n.d.). Planning for success: overcoming challenges to recruitment and conduct of an open-label emergency department–led paediatric trial. Emergency Medicine Journal. doi:10.1136/emermed-2020-209487DOI: 10.1136/emermed-2020-209487
Roper, L., Lyttle, M. D., Gamble, C., Humphreys, A., Messahel, S., Lee, E. D., . . . Woolfall, K. (2021). Seven-step framework to enhance practitioner explanations and parental understandings of research without prior consent in paediatric emergency and critical care trials. EMERGENCY MEDICINE JOURNAL, 38(3), 198-204. doi:10.1136/emermed-2020-209488DOI: 10.1136/emermed-2020-209488
Deja, E., Roper, L., Tume, L. N., Dorling, J., Gale, C., Arch, B., . . . Woolfall, K. (2021). Can they stomach it? Parent and practitioner acceptability of a trial comparing gastric residual volume measurement versus no gastric residual volume in UK NNU and PICUs: a feasibility study. PILOT AND FEASIBILITY STUDIES, 7(1). doi:10.1186/s40814-021-00784-5DOI: 10.1186/s40814-021-00784-5
Tume, L. N., Arch, B., Woolfall, K., Roper, L., Deja, E., Jones, A. P., . . . Dorling, J. (n.d.). Determining Optimal Outcome Measures in a Trial Investigating No Routine Gastric Residual Volume Measurement in Critically Ill Children. Journal of Parenteral and Enteral Nutrition. doi:10.1002/jpen.1817DOI: 10.1002/jpen.1817
Hewer, S. C. L., Smyth, A. R., Brown, M., Jones, A. P., Hickey, H., Kenna, D., . . . Williamson, P. R. (2021). Intravenous or oral antibiotic treatment in adults and children with cystic fibrosis and <i>Pseudomonas</i> <i>aeruginosa</i> infection: the TORPEDO-CF RCT. HEALTH TECHNOLOGY ASSESSMENT, 25(65), 1-+. doi:10.3310/hta25650DOI: 10.3310/hta25650
2020
Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT. (Journal article)
Appleton, R. E., Rainford, N. E., Gamble, C., Messahel, S., Humphreys, A., Hickey, H., . . . Lyttle, M. D. (2020). Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT.. Health technology assessment (Winchester, England), 24(58), 1-96. doi:10.3310/hta24580DOI: 10.3310/hta24580
Hewer, S. C. L., Smyth, A. R., Brown, M., Jones, A. P., Hickey, H., Kenna, D., . . . Grp, T. O. R. P. E. D. O. -C. F. S. (2020). Intravenous versus oral antibiotics for eradication of Pseudomonas aeruginosa in cystic fibrosis (TORPEDO-CF): a randomised controlled trial. LANCET RESPIRATORY MEDICINE, 8(10), 975-986. doi:10.1016/S2213-2600(20)30331-3DOI: 10.1016/S2213-2600(20)30331-3
Dorling, J., Tume, L., Arch, B., Woolfall, K., Latten, L., Roper, L., . . . Gale, C. (2020). Gastric residual volume measurement in British neonatal intensive care units: a survey of practice. BMJ PAEDIATRICS OPEN, 4(1). doi:10.1136/bmjpo-2019-000601DOI: 10.1136/bmjpo-2019-000601
Mitchell, E., Goodman, K., Hartley, S., Hickey, H., McDonald, A. M., Meadows, H. M., . . . Farrell, B. (2020). Where do we go from here? - Opportunities and barriers to the career development of trial managers: a survey of UK-based trial management professionals. TRIALS, 21(1). doi:10.1186/s13063-020-04316-zDOI: 10.1186/s13063-020-04316-z
Tume, L. N., Woolfall, K., Arch, B., Roper, L., Deja, E., Jones, A. P., . . . Dorling, J. (2020). Routine gastric residual volume measurement to guide enteral feeding in mechanically ventilated infants and children: the GASTRIC feasibility study. HEALTH TECHNOLOGY ASSESSMENT, 24(23), 1-+. doi:10.3310/hta24230DOI: 10.3310/hta24230
Challenges Conveying Clinical Equipoise and Exploring Patient Treatment Preferences in an Oncology Trial Comparing Active Monitoring with Radiotherapy (ROAM/EORTC 1308) (Journal article)
Sherratt, F. C., Brown, S. L., Haylock, B. J., Francis, P., Hickey, H., Gamble, C., . . . Young, B. (2020). Challenges Conveying Clinical Equipoise and Exploring Patient Treatment Preferences in an Oncology Trial Comparing Active Monitoring with Radiotherapy (ROAM/EORTC 1308). ONCOLOGIST, 25(4), E691-E700. doi:10.1634/theoncologist.2019-0571DOI: 10.1634/theoncologist.2019-0571
2019
Tume, L. N., Arch, B., Woolfall, K., Latten, L., Deja, E., Roper, L., . . . Dorling, J. (2019). Gastric Residual Volume Measurement in UK PICUs: A Survey of Practice*. PEDIATRIC CRITICAL CARE MEDICINE, 20(8), 707-713. doi:10.1097/PCC.0000000000001944DOI: 10.1097/PCC.0000000000001944
Lyttle, M., Rainford, N., Gamble, C., Messahel, S., Humphreys, A., Hickey, H., . . . Appleton, R. (2019). Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. The Lancet, 393(10186), 2125-2134. doi:10.1016/S0140-6736(19)30724-XDOI: 10.1016/S0140-6736(19)30724-X
Ramanan, A. V., Dick, A. D., Jones, A. P., Hughes, D. A., McKay, A., Rosala-Halas, A., . . . Grp, S. Y. C. A. M. O. R. E. S. (2019). Adalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis: a RCT. HEALTH TECHNOLOGY ASSESSMENT, 23(15), 1-139. doi:10.3310/hta23150DOI: 10.3310/hta23150
Woolfall, K., Roper, L., Humphreys, A., Lyttle, M. D., Messahel, S., Lee, E., . . . Appleton, R. (2019). Enhancing practitioners' confidence in recruitment and consent in the EcLiPSE trial: a mixed-method evaluation of site training - a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study. TRIALS, 20. doi:10.1186/s13063-019-3273-zDOI: 10.1186/s13063-019-3273-z
Hughes, D. A., Culeddu, G., Plumpton, C. O., Wood, E., Dick, A. D., Jones, A. P., . . . Ramanan, A. V. (2019). Cost-Effectiveness Analysis of Adalimumab for the Treatment of Uveitis Associated with Juvenile Idiopathic Arthritis. Ophthalmology, 126(3), 415-424. doi:10.1016/j.ophtha.2018.09.043DOI: 10.1016/j.ophtha.2018.09.043
2018
A phase II trial protocol of Tocilizumab in anti-TNF refractory patients with JIA-associated uveitis (the APTITUDE trial) (Journal article)
Ramanan, A. V., Dick, A. D., Jones, A. P., Guly, C., Hardwick, B., Hickey, H., . . . Beresford, M. W. (2018). A phase II trial protocol of Tocilizumab in anti-TNF refractory patients with JIA-associated uveitis (the APTITUDE trial). BMC RHEUMATOLOGY, 2(1). doi:10.1186/s41927-018-0010-2DOI: 10.1186/s41927-018-0010-2
2017
Lyttle, M. D., Gamble, C., Messahel, S., Hickey, H., Iyer, A., Woolfall, K., . . . Appleton, R. E. (2017). Emergency treatment with levetiracetam or phenytoin in status epilepticus in children-the EcLiPSE study: study protocol for a randomised controlled trial. TRIALS, 18. doi:10.1186/s13063-017-2010-8DOI: 10.1186/s13063-017-2010-8
Ramanan, A. V., Dick, A. D., Jones, A. P., McKay, A., Williamson, P. R., Compeyrot-Lacassagne, S., . . . Grp, S. Y. C. A. M. O. R. E. S. (2017). Adalimumab plus Methotrexate for Uveitis in Juvenile Idiopathic Arthritis. New England Journal of Medicine, 376(17), 1637-1646. doi:10.1056/NEJMoa1614160DOI: 10.1056/NEJMoa1614160
de Graaf, H., Sukhtankar, P., Arch, B., Ahmad, N., Lees, A., Bennett, A., . . . Faust, S. N. (2017). Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study. HEALTH TECHNOLOGY ASSESSMENT, 21(48), 1-+. Retrieved from https://www.webofscience.com/
2016
Altowati, M. A., Jones, A. P., Hickey, H., Williamson, P. R., Barakat, F. M., Plaatjies, N. C., . . . Sanderson, I. R. (2016). Assessing the feasibility of injectable growth-promoting therapy in Crohn's disease.. Pilot and feasibility studies, 2, 71. doi:10.1186/s40814-016-0112-9DOI: 10.1186/s40814-016-0112-9
Bagley, H. J., Short, H., Harman, N. L., Hickey, H. R., Gamble, C. L., Woolfall, K., . . . Williamson, P. R. (2016). A patient and public involvement (PPI) toolkit for meaningful and flexible involvement in clinical trials - a work in progress.. Research involvement and engagement, 2, 15. doi:10.1186/s40900-016-0029-8DOI: 10.1186/s40900-016-0029-8
2015
Jenkinson, M. D., Javadpour, M., Haylock, B. J., Young, B., Gillard, H., Vinten, J., . . . Weber, D. C. (2015). The ROAM/EORTC-1308 trial: Radiation versus Observation following surgical resection of Atypical Meningioma: study protocol for a randomised controlled trial. TRIALS, 16. doi:10.1186/s13063-015-1040-3DOI: 10.1186/s13063-015-1040-3
Elicitation of Expert Prior Opinion: Application to the MYPAN Trial in Childhood Polyarteritis Nodosa (Journal article)
Hampson, L. V., Whitehead, J., Eleftheriou, D., Tudur-Smith, C., Jones, R., Jayne, D., . . . Brogan, P. A. (2015). Elicitation of Expert Prior Opinion: Application to the MYPAN Trial in Childhood Polyarteritis Nodosa. PLOS ONE, 10(3). doi:10.1371/journal.pone.0120981DOI: 10.1371/journal.pone.0120981
2014
Kearney, A., McKay, A., Hickey, H., Balabanova, S., Marson, A. G., Gamble, C., & Williamson, P. (2014). Opening research sites in multicentre clinical trials within the UK: a detailed analysis of delays. BMJ Open, 4(9). doi:10.1136/bmjopen-2014-005874DOI: 10.1136/bmjopen-2014-005874
Opening research sites in multicentre clinical trials within the UK: a detailed analysis of delays (Journal article)
Kearney, A., McKay, A., Hickey, H., Balabanova, S., Marson, A. G., Gamble, C., & Williamson, P. (2014). Opening research sites in multicentre clinical trials within the UK: a detailed analysis of delays. BMJ OPEN, 4(9). doi:10.1136/bmjopen-2014-005874DOI: 10.1136/bmjopen-2014-005874
Woolfall, K., Young, B., Frith, L., Appleton, R., Iyer, A., Messahel, S., . . . Gamble, B. (2014). Doing challenging research studies in a patient centred way: qualitative study to inform a randomised controlled trial in the paediatric emergency care setting. BMJ Open, 4(e005045), 11 pages. doi:10.1136/bmjopen-2014-005045DOI: 10.1136/bmjopen-2014-005045
The trials methodological research agenda: results from a priority setting exercise (Journal article)
Smith, C. T., Hickey, H., Clarke, M., Blazeby, J., & Williamson, P. (2014). The trials methodological research agenda: results from a priority setting exercise. TRIALS, 15. doi:10.1186/1745-6215-15-32DOI: 10.1186/1745-6215-15-32
A Randomised Controlled Trial of the Clinical Effectiveness, Safety and Cost-Effectiveness of Adalimumab in Combination with Methotrexate for the Treatment of Juvenile Idiopathic Arthritis Associated Uveitis (Journal article)
Ramanan, A. V., Dick, A. D., McKay, A., Jones, A., Williamson, P., Compeyrot-Lacassagne, S., . . . Beresford, M. W. (2015). A Randomised Controlled Trial of the Clinical Effectiveness, Safety and Cost-Effectiveness of Adalimumab in Combination with Methotrexate for the Treatment of Juvenile Idiopathic Arthritis Associated Uveitis. ARTHRITIS & RHEUMATOLOGY, 67. Retrieved from https://www.webofscience.com/
The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol (Journal article)
Jenkinson, M. D., Gamble, C., Hartley, J. C., Hickey, H., Hughes, D., Blundell, M., . . . Mallucci, C. L. (2014). The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol. TRIALS, 15. doi:10.1186/1745-6215-15-4DOI: 10.1186/1745-6215-15-4
2013
Parents' Agendas in Paediatric Clinical Trial Recruitment Are Different from Researchers' and Often Remain Unvoiced: A Qualitative Study (Journal article)
Woolfall, K., Shilling, V., Hickey, H., Smyth, R. L., Sowden, E., Williamson, P. R., & Young, B. (2013). Parents' Agendas in Paediatric Clinical Trial Recruitment Are Different from Researchers' and Often Remain Unvoiced: A Qualitative Study. PLOS ONE, 8(7). doi:10.1371/journal.pone.0067352DOI: 10.1371/journal.pone.0067352
2012
Gamble, C., Nadel, S., Snape, D., McKay, A., Hickey, H., Williamson, P., . . . Young, B. (n.d.). What Parents of Children Who Have Received Emergency Care Think about Deferring Consent in Randomised Trials of Emergency Treatments: Postal Survey. PLoS ONE, 7(5), e35982. doi:10.1371/journal.pone.0035982DOI: 10.1371/journal.pone.0035982
2011
Shilling, V., Williamson, P. R., Hickey, H., Sowden, E., Beresford, M. W., Smyth, R. L., & Young, B. (2011). Communication about Children's Clinical Trials as Observed and Experienced: Qualitative Study of Parents and Practitioners. PLOS ONE, 6(7). doi:10.1371/journal.pone.0021604DOI: 10.1371/journal.pone.0021604
Processes in recruitment to randomised controlled trials of medicines for children (RECRUIT): a qualitative study (Journal article)
Shilling, V., Williamson, P. R., Hickey, H., Sowden, E., Smyth, R. L., & Young, B. (2011). Processes in recruitment to randomised controlled trials of medicines for children (RECRUIT): a qualitative study. HEALTH TECHNOLOGY ASSESSMENT, 15(15), 1-+. doi:10.3310/hta15150DOI: 10.3310/hta15150
2010
Parent/carer views about deferred consent in trials of emergency treatments in children with life-threatening illness (Journal article)
Nadel, S., Young, B., Gamble, C., Hickey, H., Williamson, P., Snape, D., . . . Glennie, L. (2010). Parent/carer views about deferred consent in trials of emergency treatments in children with life-threatening illness. Archives of Disease in Childhood, 95(Suppl 1), A39.2-A39. doi:10.1136/adc.2010.186338.87DOI: 10.1136/adc.2010.186338.87
Feasibility study to inform the design of a randomised controlled trial to eradicate <i>Pseudomonas aeruginosa</i> infection in individuals with Cystic Fibrosis (Journal article)
Hickey, H. R., Jones, A. P., Lenney, W., Williamson, P. R., & Smyth, R. L. (2010). Feasibility study to inform the design of a randomised controlled trial to eradicate <i>Pseudomonas aeruginosa</i> infection in individuals with Cystic Fibrosis. TRIALS, 11. doi:10.1186/1745-6215-11-11DOI: 10.1186/1745-6215-11-11
2005
Influence of surgical resection and post-operative complications on survival following adjuvant treatment for pancreatic cancer in the ESPAC-1 randomized controlled trial. (Journal article)
Bassi, C., Stocken, D. D., Olah, A., Friess, H., Buckels, J., Hickey, H., . . . European Study Group for Pancreatic Cancer (ESPAC). (2005). Influence of surgical resection and post-operative complications on survival following adjuvant treatment for pancreatic cancer in the ESPAC-1 randomized controlled trial.. Digestive surgery, 22(5), 353-363. doi:10.1159/000089771DOI: 10.1159/000089771
2004
A Randomized Trial of Chemoradiotherapy and Chemotherapy after Resection of Pancreatic Cancer (Journal article)
A Randomized Trial of Chemoradiotherapy and Chemotherapy after Resection of Pancreatic Cancer (2004). New England Journal of Medicine, 351(7), 726. doi:10.1056/nejm200408123510725DOI: 10.1056/nejm200408123510725