2024
Lisauskaitė, M., Nixon, G. L., Woodley, C. M., Berry, N. G., Coninckx, A., Qie, L. C., . . . O'Neill, P. M. (2024). Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in <i>Plasmodium falciparum</i>.. RSC chemical biology, 5(1), 19-29. doi:10.1039/d3cb00109aDOI: 10.1039/d3cb00109a
Hegde, S., Marriott, A. E., Pionnier, N., Steven, A., Bulman, C., Gunderson, E., . . . Turner, J. D. (2024). Combinations of the azaquinazoline anti-<i>Wolbachia</i> agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis.. Frontiers in microbiology, 15, 1346068. doi:10.3389/fmicb.2024.1346068DOI: 10.3389/fmicb.2024.1346068
2023
Larvicidal, acetylcholinesterase inhibitory activities of four essential oils and their constituents against <i>Aedes albopictus</i>, and nanoemulsion preparation (Journal article)
Li, Y., Wu, W., Jian, R., Ren, X., Chen, X., Hong, W. D., . . . Sheng, Z. (2022). Larvicidal, acetylcholinesterase inhibitory activities of four essential oils and their constituents against <i>Aedes albopictus</i>, and nanoemulsion preparation. JOURNAL OF PEST SCIENCE. doi:10.1007/s10340-022-01555-8DOI: 10.1007/s10340-022-01555-8
Hong, W. D., O'Neill, P. M., Taylor, M. J., Turner, J. D., Ward, S. A., Gusovsky, F., . . . Khile, A. S. (2023). Transformation of the Manufacturing Process from Discovery to Kilogram Scale for AWZ1066S: A Highly Specific Anti-Wolbachia Drug Candidate for a Short-Course Treatment of Filariasis. ORGANIC PROCESS RESEARCH & DEVELOPMENT. doi:10.1021/acs.oprd.2c00167DOI: 10.1021/acs.oprd.2c00167
Jeffreys, L. N., Ardrey, A., Hafiz, T. A., Dyer, L. -A., Warman, A. J., Mosallam, N., . . . Biagini, G. A. (2023). Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis. ACS INFECTIOUS DISEASES. doi:10.1021/acsinfecdis.2c00283DOI: 10.1021/acsinfecdis.2c00283
Marriott, A. E., Dagley, J. L., Hegde, S., Steven, A., Fricks, C., DiCosty, U., . . . Turner, J. D. (2023). Dirofilariasis mouse models for heartworm preclinical research. FRONTIERS IN MICROBIOLOGY, 14. doi:10.3389/fmicb.2023.1208301DOI: 10.3389/fmicb.2023.1208301
2022
Wu, W., Yang, Y., Feng, Y., Ren, X., Li, Y., Li, W., . . . Hong, W. (2022). Study of the Repellent Activity of 60 Essential Oils and Their Main Constituents against Aedes albopictus, and Nano-Formulation Development. INSECTS, 13(12). doi:10.3390/insects13121077DOI: 10.3390/insects13121077
Larvicidal Activity of Two Rutaceae Plant Essential Oils and Their Constituents Against Aedes albopictus (Diptera: Culicidae) in Multiple Formulations (Journal article)
Jian, R., Lin, Y., Li, Y., Wu, W., Ren, X., Liang, Z., . . . Sheng, Z. (2022). Larvicidal Activity of Two Rutaceae Plant Essential Oils and Their Constituents Against Aedes albopictus (Diptera: Culicidae) in Multiple Formulations. JOURNAL OF MEDICAL ENTOMOLOGY, 59(5), 1669-1677. doi:10.1093/jme/tjac083DOI: 10.1093/jme/tjac083
Tu, B., Cao, N., Zhang, B., Zheng, W., Li, J., Tang, X., . . . Wu, P. (2022). Synthesis and Biological Evaluation of Novel Fusidic Acid Derivatives as Two-in-One Agent with Potent Antibacterial and Anti-Inflammatory Activity. ANTIBIOTICS-BASEL, 11(8). doi:10.3390/antibiotics11081026DOI: 10.3390/antibiotics11081026
Amporndanai, K., Pinthong, N., O'Neill, P. M., Hong, W. D., Amewu, R. K., Pidathala, C., . . . Antonyuk, S. V. (2022). Targeting the Ubiquinol-Reduction (Q<sub>i</sub>) Site of the Mitochondrial Cytochrome <i>bc<sub>1</sub></i> Complex for the Development of Next Generation Quinolone Antimalarials. BIOLOGY-BASEL, 11(8). doi:10.3390/biology11081109DOI: 10.3390/biology11081109
Novel 18β-glycyrrhetinic acid derivatives as a Two-in-One agent with potent antimicrobial and anti-inflammatory activity (Journal article)
Tu, B., Liang, J., Ou, Y., Zhang, X., Zheng, W., Wu, R., . . . Hong, W. D. (2022). Novel 18β-glycyrrhetinic acid derivatives as a Two-in-One agent with potent antimicrobial and anti-inflammatory activity. BIOORGANIC CHEMISTRY, 122. doi:10.1016/j.bioorg.2022.105714DOI: 10.1016/j.bioorg.2022.105714
Jeffreys, L. N., Pennington, S. H., Duggan, J., Caygill, C. H., Lopeman, R. C., Breen, A. F., . . . Biagini, G. A. (2022). Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 59(3). doi:10.1016/j.ijantimicag.2022.106542DOI: 10.1016/j.ijantimicag.2022.106542
2021
Super-rapid formation of a novel super-supramolecular hydrogel with excellent antimicrobial activity (Journal article)
Guo, S., Fan, Y., Hong, W. D., Liang, J., Luo, Z., Zheng, W., . . . Zhang, K. (2021). Super-rapid formation of a novel super-supramolecular hydrogel with excellent antimicrobial activity. COMPOSITES COMMUNICATIONS, 28. doi:10.1016/j.coco.2021.100955DOI: 10.1016/j.coco.2021.100955
A novel 18β-glycyrrhetinic acid derivative supramolecular self-assembly hydrogel with antibacterial activity (Journal article)
Guo, S., Chen, S., Cao, N., Zheng, W., Li, D., Sheng, Z., . . . Hong, W. D. (2021). A novel 18β-glycyrrhetinic acid derivative supramolecular self-assembly hydrogel with antibacterial activity. JOURNAL OF MATERIALS SCIENCE, 56(30), 17254-17267. doi:10.1007/s10853-021-06396-xDOI: 10.1007/s10853-021-06396-x
McGillan, P., Berry, N. G., Nixon, G. L., Leung, S. C., Webborn, P. J. H., Wenlock, M. C., . . . O’Neill, P. M. (2021). Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis. ACS Medicinal Chemistry Letters, 12(9), 1421-1426. doi:10.1021/acsmedchemlett.1c00216DOI: 10.1021/acsmedchemlett.1c00216
Woodley, C. M., Nixon, G. L., Basilico, N., Parapini, S., Hong, W. D., Ward, S. A., . . . O'Neill, P. M. (2021). Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205. ACS MEDICINAL CHEMISTRY LETTERS, 12(7), 1077-1085. doi:10.1021/acsmedchemlett.1c00031DOI: 10.1021/acsmedchemlett.1c00031
Johnston, K. L., Hong, W. D., Turner, J. D., O'Neill, P. M., Ward, S. A., & Taylor, M. J. (2021). Anti-Wolbachia drugs for filariasis. TRENDS IN PARASITOLOGY, 37(12), 1068-1081. doi:10.1016/j.pt.2021.06.004DOI: 10.1016/j.pt.2021.06.004
Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2? (Journal article)
Stachulski, A. V., Taujanskas, J., Pate, S. L., Rajoli, R. K. R., Aljayyoussi, G., Pennington, S. H., . . . O'Neill, P. M. (2021). Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2?. ACS INFECTIOUS DISEASES, 7(6), 1317-1331. doi:10.1021/acsinfecdis.0c00478DOI: 10.1021/acsinfecdis.0c00478
Wu, P., Tang, X., Jian, R., Li, J., Lin, M., Dai, H., . . . Hong, W. D. (2021). Chemical Composition, Antimicrobial and Insecticidal Activities of Essential Oils of Discarded Perfume Lemon and Leaves (<i>Citrus Limon</i> (L.) Burm. F.) as Possible Sources of Functional Botanical Agents. FRONTIERS IN CHEMISTRY, 9. doi:10.3389/fchem.2021.679116DOI: 10.3389/fchem.2021.679116
Rajoli, R. K. R., Pertinez, H., Arshad, U., Box, H., Tatham, L., Curley, P., . . . Owen, A. (2021). Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(4), 2078-2088. doi:10.1111/bcp.14619DOI: 10.1111/bcp.14619
Wu, P., Tu, B., Liang, J., Guo, S., Cao, N., Chen, S., . . . Hong, W. D. (2021). Synthesis and biological evaluation of pentacyclic triterpenoid derivatives as potential novel antibacterial agents. BIOORGANIC CHEMISTRY, 109. doi:10.1016/j.bioorg.2021.104692DOI: 10.1016/j.bioorg.2021.104692
Oleanolic acid indole derivatives as novel α-glucosidase inhibitors: Synthesis, biological evaluation, and mechanistic analysis (Journal article)
Wu, P., He, H., Ma, H., Tu, B., Li, J., Guo, S., . . . Zhang, K. (2021). Oleanolic acid indole derivatives as novel α-glucosidase inhibitors: Synthesis, biological evaluation, and mechanistic analysis. BIOORGANIC CHEMISTRY, 107. doi:10.1016/j.bioorg.2020.104580DOI: 10.1016/j.bioorg.2020.104580
2020
Yu, P., Yang, J. -N., Yan, J. -W., Meng, Z. -Z., Hong, W. D., Roberts, A. P., . . . Li, S. (2020). A novel fluorescent probe for the detection of AmpC beta-lactamase and the application in screening beta-lactamase inhibitors.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 234. doi:10.1016/j.saa.2020.118257DOI: 10.1016/j.saa.2020.118257
Novel anti-<i>Wolbachia</i> drugs, a new approach in the treatment and prevention of veterinary filariasis? (Journal article)
Turner, J. D., Marriott, A. E., Hong, D., O'Neill, P., Ward, S. A., & Taylor, M. J. (2020). Novel anti-<i>Wolbachia</i> drugs, a new approach in the treatment and prevention of veterinary filariasis?. VETERINARY PARASITOLOGY, 279. doi:10.1016/j.vetpar.2020.109057DOI: 10.1016/j.vetpar.2020.109057
Screening of larvicidal activity of 53 essential oils and their synergistic effect for the improvement of deltamethrin efficacy against Aedes albopictus (Journal article)
Sheng, Z., Jian, R., Xie, F., Chen, B., Zhang, K., Li, D., . . . Hong, W. D. (2020). Screening of larvicidal activity of 53 essential oils and their synergistic effect for the improvement of deltamethrin efficacy against Aedes albopictus. Industrial Crops and Products, 145, 112131. doi:10.1016/j.indcrop.2020.112131DOI: 10.1016/j.indcrop.2020.112131
Design, synthesis and α-glucosidase inhibition study of novel embelin derivatives (Journal article)
Chen, X., Gao, M., Jian, R., Hong, W. D., Tang, X., Li, Y., . . . Wu, P. (2020). Design, synthesis and α-glucosidase inhibition study of novel embelin derivatives. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 35(1), 565-573. doi:10.1080/14756366.2020.1715386DOI: 10.1080/14756366.2020.1715386
2019
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis (Journal article)
Hong, W. D., Benayoud, F., Nixon, G. L., Ford, L., Johnston, K. L., Clare, R. H., . . . O'Neill, P. M. (2019). AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(4), 1414-1419. doi:10.1073/pnas.1816585116DOI: 10.1073/pnas.1816585116
Clare, R. H., Bardelle, C., Harper, P., Hong, W. D., Borjesson, U., Johnston, K. L., . . . Ward, S. A. (2019). Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-018-07826-2DOI: 10.1038/s41467-018-07826-2
A NEW RAPID ACTING ANTI-WOLBACHIA DRUG FOR ONCHOCERCIASIS AND LYMPHATIC FILARIASIS (Conference Paper)
Hong, W. D., Johnston, K. L., Berry, N. G., Gusovsky, F., Heming-Way, J., Turner, J. D., . . . O'Neill, P. M. (2019). A NEW RAPID ACTING ANTI-WOLBACHIA DRUG FOR ONCHOCERCIASIS AND LYMPHATIC FILARIASIS. In TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE Vol. 113 (pp. S4). Retrieved from https://www.webofscience.com/
2018
David Hong, W., Leung, S. C., Amporndanai, K., Davies, J., Priestley, R. S., Nixon, G. L., . . . O'Neill, P. M. (2018). Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties. ACS Medicinal Chemistry Letters, 9(12), 1205-1210. doi:10.1021/acsmedchemlett.8b00371DOI: 10.1021/acsmedchemlett.8b00371
Wu, P. -P., He, H., Hong, W. D., Wu, T. -R., Huang, G. -Y., Zhong, Y. -Y., . . . Zhang, K. (2018). The biological evaluation of fusidic acid and its hydrogenation derivative as antimicrobial and anti-inflammatory agents. INFECTION AND DRUG RESISTANCE, 11, 1945-1957. doi:10.2147/IDR.S176390DOI: 10.2147/IDR.S176390
STEREOSELECTIVE METABOLISM OF PYRIDO[3,2-D]PYRIMIDINE-CONTAINING COMPOUNDS BY ALDEHYDE OXIDASE (Conference Paper)
He, X., Siu, Y. A., Hong, W. D., Benayoud, F., & Lai, W. G. (2018). STEREOSELECTIVE METABOLISM OF PYRIDO[3,2-D]PYRIMIDINE-CONTAINING COMPOUNDS BY ALDEHYDE OXIDASE. In DRUG METABOLISM AND PHARMACOKINETICS Vol. 33 (pp. S83). doi:10.1016/j.dmpk.2017.11.273DOI: 10.1016/j.dmpk.2017.11.273
2017
Johnston, K. L., Cook, D. A. N., Berry, N. G., Hong, W. D., Clare, R. H., Goddard, M., . . . Taylor, M. J. (2017). Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library. SCIENCE ADVANCES, 3(09). doi:10.1126/sciadv.aao1551DOI: 10.1126/sciadv.aao1551
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance (Journal article)
O'Neill, P. M., Amewu, R. K., Charman, S. A., Sabbani, S., Gnädig, N. F., Straimer, J., . . . Ward, S. A. (2017). A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance. Nature Communications, 8. doi:10.1038/ncomms15159DOI: 10.1038/ncomms15159
Hong, W. D., Gibbons, P. D., Leung, S. C., Amewu, R., Stocks, P. A., Stachulski, A. V., . . . Nixon, G. L. (2017). Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis.. Journal of medicinal chemistry, 60(9), 3703-3726. doi:10.1021/acs.jmedchem.6b01718DOI: 10.1021/acs.jmedchem.6b01718
Jiang, Z., Hong, W. D., Cui, X., Gao, H., Wu, P., Chen, Y., . . . Zhang, K. (2017). Synthesis and structure-activity relationship of <i>N</i><SUP>4</SUP>-benzylamine-<i>N</i><SUP>2</SUP>-isopropyl-quinazoline-2,4-diamines derivatives as potential antibacterial agents. RSC ADVANCES, 7(82), 52227-52237. doi:10.1039/c7ra10352bDOI: 10.1039/c7ra10352b
2016
Fernandez-Alvaro, E., Hong, W. D., Nixon, G. L., O'Neil, P. M., & Calderon, F. (2016). Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action. JOURNAL OF MEDICINAL CHEMISTRY, 59(12), 5587-5603. doi:10.1021/acs.jmedchem.5b01485DOI: 10.1021/acs.jmedchem.5b01485
2015
2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties (Journal article)
Charoensutthivarakul, S., Hong, W. D., Leung, S. C., Gibbons, P. D., Bedingfield, P. T. P., Nixon, G. L., . . . O'Neill, P. M. (2015). 2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties. MEDCHEMCOMM, 6(7), 1252-1259. doi:10.1039/c5md00062aDOI: 10.1039/c5md00062a
2013
Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions (Journal article)
Ismail, H. M., O'Neill, P. M., Hong, D. W., Finn, R. D., Henderson, C. J., Wright, A. T., . . . Paine, M. J. I. (2013). Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(49), 19766-19771. doi:10.1073/pnas.1320185110DOI: 10.1073/pnas.1320185110
2012
Generation of quinolone antimalarials targeting the <i>Plasmodium falciparum</i> mitochondrial respiratory chain for the treatment and prophylaxis of malaria (Journal article)
Biagini, G. A., Fisher, N., Shone, A. E., Mubaraki, M. A., Srivastava, A., Hill, A., . . . Ward, S. A. (2012). Generation of quinolone antimalarials targeting the <i>Plasmodium falciparum</i> mitochondrial respiratory chain for the treatment and prophylaxis of malaria. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(21), 8298-8303. doi:10.1073/pnas.1205651109DOI: 10.1073/pnas.1205651109
Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods (Journal article)
Sharma, R., Lawrenson, A. S., Fisher, N. E., Warman, A. J., Shone, A. E., Hill, A., . . . Berry, N. G. (2012). Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods. JOURNAL OF MEDICINAL CHEMISTRY, 55(7), 3144-3154. doi:10.1021/jm3001482DOI: 10.1021/jm3001482
Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2) (Journal article)
Pidathala, C., Amewu, R., Pacorel, B., Nixon, G. L., Gibbons, P., Hong, W. D., . . . O'Neill, P. M. (2012). Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2). JOURNAL OF MEDICINAL CHEMISTRY, 55(5), 1831-1843. doi:10.1021/jm201179hDOI: 10.1021/jm201179h
Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2) (Journal article)
Leung, S. C., Gibbons, P., Amewu, R., Nixon, G. L., Pidathala, C., Hong, W. D., . . . O'Neill, P. M. (2012). Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2). JOURNAL OF MEDICINAL CHEMISTRY, 55(5), 1844-1857. doi:10.1021/jm201184hDOI: 10.1021/jm201184h
2010
A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of <i>Plasmodium falciparum</i> (Journal article)
Fisher, N., Hill, A., Mbekeani, A., Shone, A., Nixon, G., Stocks, P., . . . Biagini, G. A. (2010). A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of <i>Plasmodium falciparum</i>. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1797, 80. doi:10.1016/j.bbabio.2010.04.241DOI: 10.1016/j.bbabio.2010.04.241
Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH:quinone oxidoreductase (Journal article)
Biagini, G. A., Hill, A., Mbekeani, A., Shone, A., Nixon, G., Stocks, P., . . . Ward, S. A. (2010). Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH:quinone oxidoreductase. Malaria journal, 9(Suppl 2), O4. doi:10.1186/1475-2875-9-s2-o4DOI: 10.1186/1475-2875-9-s2-o4