Photo of Dr David Hong

Dr David Hong Ph.D, MRSC

Lecturer Chemistry

    Publications

    2021

    Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis (Journal article)

    Rajoli, R. K. R., Pertinez, H., Arshad, U., Box, H., Tatham, L., Curley, P., . . . Owen, A. (2021). Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(4), 2078-2088. doi:10.1111/bcp.14619

    DOI: 10.1111/bcp.14619

    Synthesis and biological evaluation of pentacyclic triterpenoid derivatives as potential novel antibacterial agents. (Journal article)

    Wu, P., Tu, B., Liang, J., Guo, S., Cao, N., Chen, S., . . . Hong, W. D. (2021). Synthesis and biological evaluation of pentacyclic triterpenoid derivatives as potential novel antibacterial agents.. Bioorganic chemistry, 109, 104692. doi:10.1016/j.bioorg.2021.104692

    DOI: 10.1016/j.bioorg.2021.104692

    Oleanolic acid indole derivatives as novel alpha-glucosidase inhibitors: Synthesis, biological evaluation, and mechanistic analysis (Journal article)

    Wu, P., He, H., Ma, H., Tu, B., Li, J., Guo, S., . . . Zhang, K. (2021). Oleanolic acid indole derivatives as novel alpha-glucosidase inhibitors: Synthesis, biological evaluation, and mechanistic analysis. BIOORGANIC CHEMISTRY, 107. doi:10.1016/j.bioorg.2020.104580

    DOI: 10.1016/j.bioorg.2020.104580

    2020

    Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2? (Journal article)

    Stachulski, A. V., Taujanskas, J., Pate, S. L., Rajoli, R. K. R., Aljayyoussi, G., Pennington, S. H., . . . O'Neill, P. M. (2020). Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2?. ACS infectious diseases. doi:10.1021/acsinfecdis.0c00478

    DOI: 10.1021/acsinfecdis.0c00478

    A novel fluorescent probe for the detection of AmpC beta-lactamase and the application in screening beta-lactamase inhibitors. (Journal article)

    Yu, P., Yang, J. -N., Yan, J. -W., Meng, Z. -Z., Hong, W. D., Roberts, A. P., . . . Li, S. (2020). A novel fluorescent probe for the detection of AmpC beta-lactamase and the application in screening beta-lactamase inhibitors.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 234. doi:10.1016/j.saa.2020.118257

    DOI: 10.1016/j.saa.2020.118257

    Novel anti-Wolbachia drugs, a new approach in the treatment and prevention of veterinary filariasis? (Journal article)

    Turner, J. D., Marriott, A. E., Hong, D., O'Neill, P., Ward, S. A., & Taylor, M. J. (2020). Novel anti-Wolbachia drugs, a new approach in the treatment and prevention of veterinary filariasis?. VETERINARY PARASITOLOGY, 279. doi:10.1016/j.vetpar.2020.109057

    DOI: 10.1016/j.vetpar.2020.109057

    Screening of larvicidal activity of 53 essential oils and their synergistic effect for the improvement of deltamethrin efficacy against Aedes albopictus (Journal article)

    Sheng, Z., Jian, R., Xie, F., Chen, B., Zhang, K., Li, D., . . . Hong, W. D. (2020). Screening of larvicidal activity of 53 essential oils and their synergistic effect for the improvement of deltamethrin efficacy against Aedes albopictus. Industrial Crops and Products, 145, 112131. doi:10.1016/j.indcrop.2020.112131

    DOI: 10.1016/j.indcrop.2020.112131

    Design, synthesis and alpha-glucosidase inhibition study of novel embelin derivatives (Journal article)

    Chen, X., Gao, M., Jian, R., Hong, W. D., Tang, X., Li, Y., . . . Wu, P. (2020). Design, synthesis and alpha-glucosidase inhibition study of novel embelin derivatives. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 35(1), 565-573. doi:10.1080/14756366.2020.1715386

    DOI: 10.1080/14756366.2020.1715386

    2019

    ANEWRAPID ACTING ANTI-WOLBACHIA DRUG FOR ONCHOCERCIASIS AND LYMPHATIC FILARIASIS (Conference Paper)

    Hong, W. D., Johnston, K. L., Berry, N. G., Gusovsky, F., Heming-Way, J., Turner, J. D., . . . O'Neill, P. M. (2019). ANEWRAPID ACTING ANTI-WOLBACHIA DRUG FOR ONCHOCERCIASIS AND LYMPHATIC FILARIASIS. In TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE Vol. 113 (pp. S4). Retrieved from http://gateway.webofknowledge.com/

    AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis (Journal article)

    Hong, W. D., Benayoud, F., Nixon, G. L., Ford, L., Johnston, K. L., Clare, R. H., . . . O'Neill, P. M. (2019). AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(4), 1414-1419. doi:10.1073/pnas.1816585116

    DOI: 10.1073/pnas.1816585116

    Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides (Journal article)

    Clare, R. H., Bardelle, C., Harper, P., Hong, W. D., Borjesson, U., Johnston, K. L., . . . Ward, S. A. (2019). Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-018-07826-2

    DOI: 10.1038/s41467-018-07826-2

    2018

    Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties (Journal article)

    David Hong, W., Leung, S. C., Amporndanai, K., Davies, J., Priestley, R. S., Nixon, G. L., . . . O'Neill, P. M. (2018). Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties. ACS Medicinal Chemistry Letters, 9(12), 1205-1210. doi:10.1021/acsmedchemlett.8b00371

    DOI: 10.1021/acsmedchemlett.8b00371

    The biological evaluation of fusidic acid and its hydrogenation derivative as antimicrobial and anti-inflammatory agents (Journal article)

    Wu, P. -P., He, H., Hong, W. D., Wu, T. -R., Huang, G. -Y., Zhong, Y. -Y., . . . Zhang, K. (2018). The biological evaluation of fusidic acid and its hydrogenation derivative as antimicrobial and anti-inflammatory agents. INFECTION AND DRUG RESISTANCE, 11, 1945-1957. doi:10.2147/IDR.S176390

    DOI: 10.2147/IDR.S176390

    STEREOSELECTIVE METABOLISM OF PYRIDO[3,2-D]PYRIMIDINE-CONTAINING COMPOUNDS BY ALDEHYDE OXIDASE (Conference Paper)

    He, X., Siu, Y. A., Hong, W. D., Benayoud, F., & Lai, W. G. (2018). STEREOSELECTIVE METABOLISM OF PYRIDO[3,2-D]PYRIMIDINE-CONTAINING COMPOUNDS BY ALDEHYDE OXIDASE. In DRUG METABOLISM AND PHARMACOKINETICS Vol. 33 (pp. S83). Retrieved from http://gateway.webofknowledge.com/

    2017

    Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library (Journal article)

    Johnston, K. L., Cook, D. A. N., Berry, N. G., Hong, W. D., Clare, R. H., Goddard, M., . . . Taylor, M. J. (2017). Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library. SCIENCE ADVANCES, 3(09). doi:10.1126/sciadv.aao1551

    DOI: 10.1126/sciadv.aao1551

    A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance (Journal article)

    O'Neill, P. M., Amewu, R. K., Charman, S. A., Sabbani, S., Gnädig, N. F., Straimer, J., . . . Ward, S. A. (2017). A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance. Nature Communications, 8. doi:10.1038/ncomms15159

    DOI: 10.1038/ncomms15159

    Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis. (Journal article)

    Hong, W. D., Gibbons, P. D., Leung, S. C., Amewu, R., Stocks, P. A., Stachulski, A. V., . . . Nixon, G. L. (2017). Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis.. Journal of medicinal chemistry, 60(9), 3703-3726. doi:10.1021/acs.jmedchem.6b01718

    DOI: 10.1021/acs.jmedchem.6b01718

    Synthesis and structure-activity relationship of N-4-benzylamine-N-2-isopropyl-quinazoline-2,4-diamines derivatives as potential antibacterial agents (Journal article)

    Jiang, Z., Hong, W. D., Cui, X., Gao, H., Wu, P., Chen, Y., . . . Zhang, K. (2017). Synthesis and structure-activity relationship of N-4-benzylamine-N-2-isopropyl-quinazoline-2,4-diamines derivatives as potential antibacterial agents. RSC ADVANCES, 7(82), 52227-52237. doi:10.1039/c7ra10352b

    DOI: 10.1039/c7ra10352b

    2016

    Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action (Journal article)

    Fernandez-Alvaro, E., Hong, W. D., Nixon, G. L., O'Neil, P. M., & Calderon, F. (2016). Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action. JOURNAL OF MEDICINAL CHEMISTRY, 59(12), 5587-5603. doi:10.1021/acs.jmedchem.5b01485

    DOI: 10.1021/acs.jmedchem.5b01485

    2015

    2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties (Journal article)

    Charoensutthivarakul, S., Hong, W. D., Leung, S. C., Gibbons, P. D., Bedingfield, P. T. P., Nixon, G. L., . . . O'Neill, P. M. (2015). 2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties. MEDCHEMCOMM, 6(7), 1252-1259. doi:10.1039/c5md00062a

    DOI: 10.1039/c5md00062a

    2013

    Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions (Journal article)

    Ismail, H. M., O'Neill, P. M., Hong, D. W., Finn, R. D., Henderson, C. J., Wright, A. T., . . . Paine, M. J. I. (2013). Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions. Proceedings of the National Academy of Sciences, 110(49), 19766-19771. doi:10.1073/pnas.1320185110

    DOI: 10.1073/pnas.1320185110

    2012

    Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria (Journal article)

    Biagini, G. A., Fisher, N., Shone, A. E., Mubaraki, M. A., Srivastava, A., Hill, A., . . . Ward, S. A. (2012). Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(21), 8298-8303. doi:10.1073/pnas.1205651109

    DOI: 10.1073/pnas.1205651109

    Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods (Journal article)

    Sharma, R., Lawrenson, A. S., Fisher, N. E., Warman, A. J., Shone, A. E., Hill, A., . . . Berry, N. G. (2012). Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods. JOURNAL OF MEDICINAL CHEMISTRY, 55(7), 3144-3154. doi:10.1021/jm3001482

    DOI: 10.1021/jm3001482

    Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2) (Journal article)

    Pidathala, C., Amewu, R., Pacorel, B., Nixon, G. L., Gibbons, P., Hong, W. D., . . . O'Neill, P. M. (2012). Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2). JOURNAL OF MEDICINAL CHEMISTRY, 55(5), 1831-1843. doi:10.1021/jm201179h

    DOI: 10.1021/jm201179h

    Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2) (Journal article)

    Leung, S. C., Gibbons, P., Amewu, R., Nixon, G. L., Pidathala, C., Hong, W. D., . . . O'Neill, P. M. (2012). Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2). JOURNAL OF MEDICINAL CHEMISTRY, 55(5), 1844-1857. doi:10.1021/jm201184h

    DOI: 10.1021/jm201184h

    2010

    Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH:quinone oxidoreductase (Journal article)

    Biagini, G. A., Hill, A., Mbekeani, A., Shone, A., Nixon, G., Stocks, P., . . . Ward, S. A. (2010). Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH:quinone oxidoreductase. Malaria Journal, 9(S2). doi:10.1186/1475-2875-9-s2-o4

    DOI: 10.1186/1475-2875-9-s2-o4

    A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum (Journal article)

    Fisher, N., Hill, A., Mbekeani, A., Shone, A., Nixon, G., Stocks, P., . . . Biagini, G. A. (2010). A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1797, 80. doi:10.1016/j.bbabio.2010.04.241

    DOI: 10.1016/j.bbabio.2010.04.241