Photo of Dr Marco Giardiello

Dr Marco Giardiello PhD, MChem, AFHEA

UKRI Research Fellow Chemistry

Publications

2019

Nanomedicines towards targeting intracellularMtbfor the treatment of tuberculosis (Journal article)

Donnellan, S., & Giardiello, M. (2019). Nanomedicines towards targeting intracellularMtbfor the treatment of tuberculosis. Journal of Interdisciplinary Nanomedicine, 4(3), 76-85. doi:10.1002/jin2.61

DOI: 10.1002/jin2.61

2018

Barriers for the development, translation, and implementation of nanomedicine: an African perspective (Journal article)

Saravanan, M., Ramachandran, B., Hamed, B., & Giardiello, M. (n.d.). Barriers for the development, translation, and implementation of nanomedicine: an African perspective. Journal of Interdisciplinary Nanomedicine. doi:10.1002/jin2.43

DOI: 10.1002/jin2.43

Assessment of interactions of efavirenz solid drug nanoparticles with human immunological and haematological systems (Journal article)

Liptrott, N. J., Giardiello, M., McDonald, T. O., Rannard, S. P., & Owen, A. (2018). Assessment of interactions of efavirenz solid drug nanoparticles with human immunological and haematological systems. JOURNAL OF NANOBIOTECHNOLOGY, 16. doi:10.1186/s12951-018-0349-y

DOI: 10.1186/s12951-018-0349-y

2017

In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line (Journal article)

Curley, P., Giardiello, M., Liptrott, N. J., Dickens, D., Moss, D. M., Hobson, J. J., . . . Owen, A. (2017). In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line. Journal of Interdisciplinary Nanomedicine, 2(3), 157-169. doi:10.1002/jin2.32

DOI: 10.1002/jin2.32

Intracellular delivery of nano-formulated antituberculosis drugs enhances bactericidal activity (Journal article)

Donnellan, S., Stone, V., Johnston, H., Giardiello, M., Owen, A., Rannard, S., . . . Stevenson, K. (2017). Intracellular delivery of nano-formulated antituberculosis drugs enhances bactericidal activity. Journal of Interdisciplinary Nanomedicine, 2(3), 146-156. doi:10.1002/jin2.27

DOI: 10.1002/jin2.27

Lack of interaction of lopinavir solid drug nanoparticles with cells of the immune system (Journal article)

Liptrott, N. J., Giardiello, M., McDonald, T. O., Rannard, S. P., & Owen, A. (2017). Lack of interaction of lopinavir solid drug nanoparticles with cells of the immune system. NANOMEDICINE, 12(17), 2043-2054. doi:10.2217/nnm-2017-0095

DOI: 10.2217/nnm-2017-0095

Dual-stimuli responsive injectable nanogel/solid drug nanoparticle nanocomposites for release of poorly soluble drugs (Conference Paper)

Town, A., Gurjar, R., Giardiello, M., Briggs, M., Akhtar, R., Siccardi, M., & McDonald, T. (2017). Dual-stimuli responsive injectable nanogel/solid drug nanoparticle nanocomposites for release of poorly soluble drugs. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 254. doi:10.1039/C6NR07858C

DOI: 10.1039/C6NR07858C

Six year manufacturing to human clinical trial programme for the first oral dosed HIV nanomedicines (Conference Paper)

Giardiello, M., McDonald, T., Liptrott, N., Martin, P., Smith, D., Siccardi, M., . . . Rannard, S. (2017). Six year manufacturing to human clinical trial programme for the first oral dosed HIV nanomedicines. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 254. Retrieved from http://gateway.webofknowledge.com/

Dual-stimuli responsive injectable microgel/solid drug nanoparticle nanocomposites for release of poorly soluble drugs (Journal article)

Town, A. R., Giardiello, M., Gurjar, R., Siccardi, M., Briggs, M. E., Akhtar, R., & McDonald, T. O. (2017). Dual-stimuli responsive injectable microgel/solid drug nanoparticle nanocomposites for release of poorly soluble drugs. Nanoscale, 9(19), 6302-6314. doi:10.1039/c6nr07858c

DOI: 10.1039/c6nr07858c

Assessment of the potential interactions of hyperbranched polydendrons with immunological and haematological systems. (Poster)

David, C., Giardiello, M., Rannard, S. P., Owen, A., & Liptrott, N. J. (2017). Assessment of the potential interactions of hyperbranched polydendrons with immunological and haematological systems.. Poster session presented at the meeting of BSNM Early Career Researchers' Meeting. Belfast.

2016

Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies (Journal article)

Giardiello, M., Liptrott, M. J., McDonald, T. O., Moss, D., Siccardi, M., Martin, P., . . . Owen, A. (2016). Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies. Nature Communications, 7. doi:10.1038/ncomms13184

DOI: 10.1038/ncomms13184

Towards a rational design of solid drug nanoparticles with optimised pharmacological properties. (Journal article)

Siccardi, M., Martin, P., Smith, D., Curley, P., McDonald, T., Giardiello, M., . . . Owen, A. (2016). Towards a rational design of solid drug nanoparticles with optimised pharmacological properties.. Journal of interdisciplinary nanomedicine, 1(3), 110-123. doi:10.1002/jin2.21

DOI: 10.1002/jin2.21

Early Investigation of the Stabilisation Effects of Polymer and Surfactant Combinations in the Formulation of Solid Drug Nanoparticles (Conference Paper)

Savage, A. C., Giardiello, M., Owen, A., & Rannard, S. (2016). Early Investigation of the Stabilisation Effects of Polymer and Surfactant Combinations in the Formulation of Solid Drug Nanoparticles. In British Society of Nanomedicine Early Career Meeting Vol. 1 (pp. 78). Swansea University. doi:10.1002/jin2.14

DOI: 10.1002/jin2.14

Early Investigation of the Stabilisation Effects of Polymer and Surfactant Combinations in the Formulation of Solid Drug Nanoparticles (Poster)

Savage, A. C., Giardiello, M., Owen, A., & Rannard, S. P. (2016). Early Investigation of the Stabilisation Effects of Polymer and Surfactant Combinations in the Formulation of Solid Drug Nanoparticles. Poster session presented at the meeting of Royal Society of Chemistry Early Career Symposium. University of Strathclyde.

Stable, polymer-directed and SPION-nucleated magnetic amphiphilic block copolymer nanoprecipitates with readily reversible assembly in magnetic fields (Journal article)

Giardiello, M., Hatton, F. L., Slater, R. A., Chambon, P., North, J., Peacock, A. K., . . . Rannard, S. P. (2016). Stable, polymer-directed and SPION-nucleated magnetic amphiphilic block copolymer nanoprecipitates with readily reversible assembly in magnetic fields. Nanoscale, 8(13), 7224-7231. doi:10.1039/c6nr00788k

DOI: 10.1039/c6nr00788k

2015

Augmented Inhibition of CYP3A4 in Human Primary Hepatocytes by Ritonavir Solid Drug Nanoparticles (Journal article)

Martin, P., Giardiello, M., McDonald, T. C., Smith, D., Siccardi, M., Rannard, S. P., & Owen, A. (2015). Augmented Inhibition of CYP3A4 in Human Primary Hepatocytes by Ritonavir Solid Drug Nanoparticles. MOLECULAR PHARMACEUTICS, 12(10), 3556-3568. doi:10.1021/acs.molpharmaceut.5b00204

DOI: 10.1021/acs.molpharmaceut.5b00204

The Application of Nanotechnology to Drug Delivery in Medicine (Chapter)

McDonald, T. O., Siccardi, M., Moss, D., Liptrott, N., Giardiello, M., Rannard, S., & Owen, A. (2015). The Application of Nanotechnology to Drug Delivery in Medicine. In Nanoengineering (pp. 173-223). Elsevier. doi:10.1016/b978-0-444-62747-6.00007-5

DOI: 10.1016/b978-0-444-62747-6.00007-5

Flow cytometric analysis of the physical and protein-binding characteristics of solid drug nanoparticle suspensions (Journal article)

Liptrott, N. J., Giardiello, M., Hunter, J. W., Tatham, L., Tidbury, L. R., Siccardi, M., . . . Owen, A. (2015). Flow cytometric analysis of the physical and protein-binding characteristics of solid drug nanoparticle suspensions. NANOMEDICINE, 10(9), 1407-1421. doi:10.2217/NNM.14.77

DOI: 10.2217/NNM.14.77

Multiple and Co-Nanoprecipitation Studies of Branched Hydrophobic Copolymers and A-B Amphiphilic Block Copolymers, Allowing Rapid Formation of Sterically Stabilized Nanoparticles in Aqueous Media (Journal article)

Ford, J., Chambon, P., North, J., Hatton, F. L., Giardiello, M., Owen, A., & Rannard, S. P. (2015). Multiple and Co-Nanoprecipitation Studies of Branched Hydrophobic Copolymers and A-B Amphiphilic Block Copolymers, Allowing Rapid Formation of Sterically Stabilized Nanoparticles in Aqueous Media. MACROMOLECULES, 48(6), 1883-1893. doi:10.1021/acs.macromol.5b00099

DOI: 10.1021/acs.macromol.5b00099

2014

Antiretroviral Solid Drug Nanoparticles with Enhanced Oral Bioavailability: Production, Characterization, and In Vitro–In Vivo Correlation (Journal article)

McDonald, T. O., Giardiello, M., Martin, P., Siccardi, M., Liptrott, N. J., Roberts, P., . . . Owen, A. (2014). Antiretroviral Solid Drug Nanoparticles with Enhanced Oral Bioavailability: Production, Characterization, and In Vitro–In Vivo Correlation. Advanced Healthcare Materials, 3(3), 400-411. doi:10.1002/adhm.201300280

DOI: 10.1002/adhm.201300280

Flow cytometric analysis of the physical and protein-binding characteristics of solid drug nanoparticle suspensions (Journal article)

Liptrott, N., Giardiello, M., Hunter, J. W., Tatham, L., Tidbury, L. R., Siccardi, M., . . . Owen, A. (2014). Flow cytometric analysis of the physical and protein-binding characteristics of solid drug nanoparticle suspensions. Nanomedicine (London).

In vitro characterization of efavirenz-containing solid drug nanoparticles (Conference Paper)

King, S. C., Oliveira, M., Moisi, D., Brenner, B., Giardiello, M., Rannard, S. P., . . . Geretti, A. M. (2014). In vitro characterization of efavirenz-containing solid drug nanoparticles. In ANTIVIRAL THERAPY Vol. 19 (pp. A126). Retrieved from http://gateway.webofknowledge.com/

The in vivo effects of solid drug nanoparticle and conventional efavirenz on anxiogenesis in rodents (Poster)

Curley, P., Giardiello, M., Liptrott, N., Martin, P., McDonald, T., Siccardi, M., . . . Owen, A. (2014). The in vivo effects of solid drug nanoparticle and conventional efavirenz on anxiogenesis in rodents. Poster session presented at the meeting of 21st Conference on Retroviruses and Opportunistic Infections. Boston, USA.

2013

pH-Responsive Lanthanide Complexes Based on Reversible Ligation of a Diphenylphosphinamide (Journal article)

Giardiello, M., Botta, M., & Lowe, M. P. (2013). pH-Responsive Lanthanide Complexes Based on Reversible Ligation of a Diphenylphosphinamide. INORGANIC CHEMISTRY, 52(24), 14264-14269. doi:10.1021/ic402205j

DOI: 10.1021/ic402205j

High-throughput nanoprecipitation of the organic antimicrobial triclosan and enhancement of activity against Escherichia coli (Journal article)

McDonald, T. O., Tatham, L. M., Southworth, F. Y., Giardiello, M., Martin, P., Liptrott, N. J., . . . Rannard, S. P. (2013). High-throughput nanoprecipitation of the organic antimicrobial triclosan and enhancement of activity against Escherichia coli. JOURNAL OF MATERIALS CHEMISTRY B, 1(35), 4455-4465. doi:10.1039/c3tb20543f

DOI: 10.1039/c3tb20543f

Mediation of in Vitro Cytochrome P450 Activity by Common Pharmaceutical Excipients (Journal article)

Martin, P., Giardiello, M., McDonald, T. O., Rannard, S. P., & Owen, A. (2013). Mediation of in Vitro Cytochrome P450 Activity by Common Pharmaceutical Excipients. MOLECULAR PHARMACEUTICS, 10(7), 2739-2748. doi:10.1021/mp400175n

DOI: 10.1021/mp400175n

Compositions of Lopinavir and Ritonavir (Patent)

Rannard, S., Owen, A., Smith, D., Giardiello, M., McDonald, T., & Martin, P. (2013). Compositions of Lopinavir and Ritonavir.

HIV Drug Nanodispersions (Patent)

Rannard, S., Owen, A., Giardiello, M., McDonald, T., Smith, D., & Martin, P. (2013). HIV Drug Nanodispersions.

Nanoparticles Formulation of Lopinavir (Patent)

Rannard, S., Owen, A., Smith, S., Giardiello, M., McDonald, T., Martin, P., & Long, J. (2013). Nanoparticles Formulation of Lopinavir.

Nanomedicines for HIV therapy. (Journal article)

Siccardi, M., Martin, P., McDonald, T. O., Liptrott, N. J., Giardiello, M., Rannard, S., & Owen, A. (2013). Nanomedicines for HIV therapy.. Therapeutic delivery, 4(2), 153-156. doi:10.4155/tde.12.156

DOI: 10.4155/tde.12.156

Enhanced Pharmacological Properties of Efavirenz Formulated as Solid Drug Nanoparticles (Conference Paper)

Martin, P., Liptrott, N., McDonald, T., Giardiello, M., Roberts, P., Curley, P., . . . Owen, A. (2013). Enhanced Pharmacological Properties of Efavirenz Formulated as Solid Drug Nanoparticles. In 20th Conference on Retroviruses and Opportunistic Infections. Atlanta, USA.

High-throughput nanoprecipitation of the organic antimicrobial triclosan and enhancement of activity against Escherichia coli (Journal article)

McDonald, T. O., Tatham, L. M., Southworth, F. Y., Giardiello, M., Martin, P., Liptrott, N. J., . . . Rannard, S. P. (2013). High-throughput nanoprecipitation of the organic antimicrobial triclosan and enhancement of activity against Escherichia coli. Journal of Materials Chemistry B, 1(35), 4455. doi:10.1039/c3tb20543f

DOI: 10.1039/c3tb20543f

Reactions of hydrophobic organic nanoparticle mixtures in water: nanoparticle-on-nanoparticle oxidative dye bleaching (Journal article)

Giardiello, M., McDonald, T. O., Lee, J. -S., Roberts, A. D., Owen, A., & Rannard, S. P. (2013). Reactions of hydrophobic organic nanoparticle mixtures in water: nanoparticle-on-nanoparticle oxidative dye bleaching. GREEN CHEMISTRY, 15(6), 1590-1599. doi:10.1039/c3gc40573g

DOI: 10.1039/c3gc40573g

2012

Facile synthesis of complex multi-component organic and organic-magnetic inorganic nanocomposite particles (Journal article)

Giardiello, M., McDonald, T. O., Martin, P., Owen, A., & Rannard, S. P. (2012). Facile synthesis of complex multi-component organic and organic-magnetic inorganic nanocomposite particles. JOURNAL OF MATERIALS CHEMISTRY, 22(47), 24744-24752. doi:10.1039/c2jm34974d

DOI: 10.1039/c2jm34974d

Rapid "bottom-up" production of organic nanoparticles: From drug bioavailability enhancement to fluorescence studies of cellular accumulation (Journal article)

Rannard, S. P., McDonald, T. O., Owen, A., Giardiello, M., Martin, P., & Liptrot, N. (2012). Rapid "bottom-up" production of organic nanoparticles: From drug bioavailability enhancement to fluorescence studies of cellular accumulation. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 244. Retrieved from http://gateway.webofknowledge.com/

Multicomponent Organic Nanoparticles for Fluorescence Studies in Biological Systems (Journal article)

McDonald, T. O., Martin, P., Patterson, J. P., Smith, D., Giardiello, M., Marcello, M., . . . Rannard, S. (2012). Multicomponent Organic Nanoparticles for Fluorescence Studies in Biological Systems. ADVANCED FUNCTIONAL MATERIALS, 22(12), 2469-2478. doi:10.1002/adfm.201103059

DOI: 10.1002/adfm.201103059

2011

Synthesis of lanthanide(III) complexes appended with a diphenylphosphinamide and their interaction with human serum albumin (Journal article)

Giardiello, M., Botta, M., & Lowe, M. P. (2011). Synthesis of lanthanide(III) complexes appended with a diphenylphosphinamide and their interaction with human serum albumin. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 71(3-4), 435-444. doi:10.1007/s10847-011-0009-4

DOI: 10.1007/s10847-011-0009-4

Cell-Permeable Ln(III) Chelate-Functionalized InP Quantum Dots As Multimodal Imaging Agents (Journal article)

Stasiuk, G. J., Tamang, S., Imbert, D., Poillot, C., Giardiello, M., Tisseyre, C., . . . Mazzanti, M. (2011). Cell-Permeable Ln(III) Chelate-Functionalized InP Quantum Dots As Multimodal Imaging Agents. ACS NANO, 5(10), 8193-8201. doi:10.1021/nn202839w

DOI: 10.1021/nn202839w

Compositions of Lopinavir & Ritonavir (Patent)

Rannard, S., Owen, A., Smith, D., Giardiello, M., McDonald, T., & Martin, P. (2011). Compositions of Lopinavir & Ritonavir.

HIV Drug Nanodispersions (Patent)

Rannard, S., Owen, A., McDonald, T., Smith, D., Giardiello, M., & Martin, P. (2011). HIV Drug Nanodispersions.

Nanoparticles Formulation of Lopinavir (Patent)

Rannard, S., Owen, A., Smith, D., Giardiello, M., McDonald, T., Martin, P., & Long, J. (2011). Nanoparticles Formulation of Lopinavir.

2010

Influence of particle size and surface charge on the cytotoxicity of nanodispersions (Journal article)

Martin, P., McDonald, T., Smith, D., Giardiello, M., Rannard, S., & Owen, A. (2010). Influence of particle size and surface charge on the cytotoxicity of nanodispersions. DRUG METABOLISM REVIEWS, 42, 50-51. Retrieved from http://gateway.webofknowledge.com/

2009

Luminescence Study of Eu(III) Analogues of Esterase-Activated Magnetic Resonance Contrast Agents (Journal article)

Giardiello, M., & Lowe, M. P. (2009). Luminescence Study of Eu(III) Analogues of Esterase-Activated Magnetic Resonance Contrast Agents. INORGANIC CHEMISTRY, 48(17), 8515-8522. doi:10.1021/ic901284t

DOI: 10.1021/ic901284t

2007

An esterase-activated magnetic resonance contrast agent (Journal article)

Giardiello, M., Lowe, M. P., & Botta, M. (2007). An esterase-activated magnetic resonance contrast agent. CHEMICAL COMMUNICATIONS, (39), 4044-4046. doi:10.1039/b711989e

DOI: 10.1039/b711989e

2003

Room-temperature cyclometallation of amines, imines and oxazolines with [MCl2Cp*](2) (M = Rh, Ir) and [RuCl2(p-cymene)](2) (Journal article)

Davies, D. L., Al-Duaij, O., Fawcett, J., Giardiello, M., Hilton, S. T., & Russell, D. R. (2003). Room-temperature cyclometallation of amines, imines and oxazolines with [MCl2Cp*](2) (M = Rh, Ir) and [RuCl2(p-cymene)](2). DALTON TRANSACTIONS, (21), 4132-4138. doi:10.1039/b303737a

DOI: 10.1039/b303737a

2001

Redox behavior of boronato-functionalized 1,1 '-bis(diphenylphosphino)ferrocenes (Journal article)

Zanello, P., Cinquantini, A., Fontani, M., Giardiello, M., Giorgi, G., Landis, C. R., & Kimmich, B. F. M. (2001). Redox behavior of boronato-functionalized 1,1 '-bis(diphenylphosphino)ferrocenes. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 637, 800-804. doi:10.1016/S0022-328X(01)01132-9

DOI: 10.1016/S0022-328X(01)01132-9