Photo of Dr Simon Tew

Dr Simon Tew BSc, Ph.D

Senior Lecturer in Orthopaedic Sciences Musculoskeletal & Ageing Science

    Research

    Understanding the role of post transcriptional gene regulation in musculoskeletal disease.

    My group is interested in the biology of cells within our joints and in understanding mechanisms that lead to age-related musculoskeletal diseases such as osteoarthritis and osteoporosis. We are particularly interested in novel ways in which genes are controlled in these tissues. We are focussing on post-transcriptional regulation and have ongoing studies into the effects of mRNA decay, polyadenylation and RNA binding protein function in skeletal pathology.

    We use a range of in vivo and in vitro experimental model systems and employ an equally wide range of techniques to analyse these systems, spanning cutting edge transcriptomic analysis of cellular systems, studies of molecular interaction, gene and protein expression analysis and tissue imaging.

    Research Grants

    Sara Ibrahim AlSalhi 201369309 bench fees

    ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

    March 2020 - February 2024

    Improving the annotation of genes across the equine genome

    HORSERACE BETTING LEVY BOARD (UK)

    November 2022 - February 2024

    Bench fees - Haifa Mohammed A Majali - (201773323)

    ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

    February 2024 - January 2028

    Bench fees - Maryam Saad D Alotaibi (201772012)

    ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

    November 2023 - October 2027

    INVESTIGATING THE ROLE OF THE RNA BINDING PROTEIN HuR IN MUSCULOSKELETAL DEVELOPMENT AND DISEASE

    MEDICAL RESEARCH COUNCIL

    July 2016 - December 2019

    Anti-cytokine gene silencing in canine synovial cells

    PET PLAN CHARITABLE TRUST (UK)

    January 2012 - December 2013

    Defining the post-transcriptional regulatory mechanisms controlling a gene that performs an essential role in cartilage function and regeneration

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

    December 2012 - November 2015