Dr Simon Tew BSc, Ph.D
Senior Lecturer in Orthopaedic Sciences Musculoskeletal & Ageing Science
- +44 (0)151 794 9029 / +44 (0)151 795 6235
- Work email Simon.Tew@liverpool.ac.uk
- Personal WebsiteSimon Tew Lab Website
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Publications
Selected Publications
- Translational regulation contributes to the secretory response of chondrocytic cells following exposure to Interleukin-1β (Journal article - 2019)
- Cross-species gene modules emerge from a systems biology approach to osteoarthritis (Journal article - 2017)
- A systems biology approach to defining regulatory mechanisms for cartilage and tendon cell phenotypes (Journal article - 2016)
- RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes (Journal article - 2016)
- Transcriptome‐Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes (Journal article - 2014)
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2023
Analysis of RNA Polyadenylation in Healthy and Osteoarthritic Human Articular Cartilage (Journal article)
Winstanley-Zarach, P., Rot, G., Kuba, S., Smagul, A., Peffers, M. J. J., & Tew, S. R. R. (2023). Analysis of RNA Polyadenylation in Healthy and Osteoarthritic Human Articular Cartilage. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(7). doi:10.3390/ijms24076611Editorial: Epigenetic regulation of the musculoskeletal system in health, disease, and aging (Journal article)
Goljanek-Whysall, K., Tew, S., Peffers, M. J., & Kanakis, I. (2023). Editorial: Epigenetic regulation of the musculoskeletal system in health, disease, and aging. FRONTIERS IN ENDOCRINOLOGY, 14. doi:10.3389/fendo.2023.1143210Identifying alternative polyadenylation events associated with osteoarthritis (Conference Paper)
Winstanley-Zarach, P., Rot, G., Smagul, A., Peffers, M., & Tew, S. R. (2023). Identifying alternative polyadenylation events associated with osteoarthritis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 104 (pp. A17-A18). Retrieved from https://www.webofscience.com/2022
Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations (Journal article)
Al-Maslamani, N. A., Oldershaw, R., Tew, S., Curran, J., D'Hooghe, P., Yamamoto, K., & Horn, H. F. (2022). Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations. CELLS, 11(24). doi:10.3390/cells11244011USE OF A 3′ RNA SEQUENCING APPROACH TO DETERMINE DIFFERENTIAL TRANSCRIPT EXPRESSION AND ALTERNATIVE POLYADENYLATION SITE USAGE BETWEEN AGE MATCHED, HEALTHY AND OSTEOARTHRITIC KNEE CARTILAGE (Conference Paper)
Winstanley-Zarach, P., Kuba, S., Smagul, A., Peffers, M. J., Rot, G., & Tew, S. R. (2022). USE OF A 3′ RNA SEQUENCING APPROACH TO DETERMINE DIFFERENTIAL TRANSCRIPT EXPRESSION AND ALTERNATIVE POLYADENYLATION SITE USAGE BETWEEN AGE MATCHED, HEALTHY AND OSTEOARTHRITIC KNEE CARTILAGE. In OSTEOARTHRITIS AND CARTILAGE Vol. 30 (pp. S351-S352). Retrieved from https://www.webofscience.com/2021
Characterisation of key proteoglycans in the cranial cruciate ligaments (CCLs) from two dog breeds with different predispositions to CCL disease and rupture. (Journal article)
Allaith, S., Tew, S. R., Hughes, C. E., Clegg, P. D., Canty-Laird, E. G., & Comerford, E. J. (2021). Characterisation of key proteoglycans in the cranial cruciate ligaments (CCLs) from two dog breeds with different predispositions to CCL disease and rupture.. Veterinary journal (London, England : 1997), 272, 105657. doi:10.1016/j.tvjl.2021.1056572019
Insulin-like growth factor binding protein (IGFBP6) is a cross-species tendon marker. (Journal article)
Turlo, A. J., Mueller-Breckenridge, A. J., Zamboulis, D. E., Tew, S. R., Canty-Laird, E. G., & Clegg, P. D. (2019). Insulin-like growth factor binding protein (IGFBP6) is a cross-species tendon marker.. European Cells and Materials, 38, 123-136. doi:10.22203/ecm.v038a10Translational regulation contributes to the secretory response of chondrocytic cells following exposure to Interleukin-1β (Journal article)
Mcdermott, B., Peffers, M., McDonagh, B., & Tew, S. R. (2019). Translational regulation contributes to the secretory response of chondrocytic cells following exposure to Interleukin-1β. Journal of Biological Chemistry, 294(35), 13027-13029. doi:10.1074/jbc.RA118.006865Evidence for alternative polyadenylation of the ADAMTS5 mRNA creating a heterogenous pool of transcripts that differ in their response to post-transcriptional cues (Conference Paper)
McDermott, B. T., Chinaemerem, O., Chesters, L., & Tew, S. R. (2019). Evidence for alternative polyadenylation of the ADAMTS5 mRNA creating a heterogenous pool of transcripts that differ in their response to post-transcriptional cues. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A27). Retrieved from https://www.webofscience.com/2018
The emerging fibroblast-like synoviocyte channelome (Journal article)
Tew, S. R., & Barrett-Jolley, R. (2018). The emerging fibroblast-like synoviocyte channelome. EXPERIMENTAL PHYSIOLOGY, 103(8), 1043-1044. doi:10.1113/EP087087Variations in internal structure, composition and protein distribution between intra- and extra-articular knee ligaments and tendons (Journal article)
Kharaz, Y. A., Canty-Laird, E. G., Tew, S. R., & Comerford, E. J. (2018). Variations in internal structure, composition and protein distribution between intra- and extra-articular knee ligaments and tendons. JOURNAL OF ANATOMY, 232(6), 943-955. doi:10.1111/joa.12802CHARACTERISATION OF STEM CELL POPULATIONS WITHIN NORMAL AND RUPTURED ANTERIOR CRUCIATE LIGAMENTS' (Conference Paper)
Barrow, M., Tew, S., Comerford, E., McNicholas, M., & Oldershaw, R. (2018). CHARACTERISATION OF STEM CELL POPULATIONS WITHIN NORMAL AND RUPTURED ANTERIOR CRUCIATE LIGAMENTS'. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S405-S406). doi:10.1016/j.joca.2018.02.786THE EFFECT OF U3 SNORNA KNOCKDOWN ON THE CHONDROCYTE PROTEOME (Conference Paper)
Smagul, A., Tew, S., & Peffers, M. J. (2018). THE EFFECT OF U3 SNORNA KNOCKDOWN ON THE CHONDROCYTE PROTEOME. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S165). doi:10.1016/j.joca.2018.02.359Interaction with macrophages attenuates equine fibroblast-like synoviocyte ADAMTS5 (aggrecanase-2) gene expression following inflammatory stimulation (Journal article)
Morgan, R. E., Clegg, P. D., Hunt, J. A., Innes, J. F., & Tew, S. R. (2018). Interaction with macrophages attenuates equine fibroblast-like synoviocyte ADAMTS5 (aggrecanase-2) gene expression following inflammatory stimulation. JOURNAL OF ORTHOPAEDIC RESEARCH, 36(08), 2178-2185. doi:10.1002/jor.238912017
Cross-species gene modules emerge from a systems biology approach to osteoarthritis (Journal article)
Mueller, A. J., Canty-Laird, E. G., Clegg, P. D., & Tew, S. R. (2017). Cross-species gene modules emerge from a systems biologyapproach to osteoarthritis. NPJ Systems Biology and Applications, 3. doi:10.1038/s41540-017-0014-32016
A systems biology approach to defining regulatory mechanisms for cartilage and tendon cell phenotypes (Journal article)
Mueller, A. J., Tew, S. R., Vasieva, O., Clegg, P. D., & Canty-Laird, E. G. (2016). A systems biology approach to defining regulatory mechanisms for cartilage and tendon cell phenotypes. SCIENTIFIC REPORTS, 6, 1-14. doi:10.1038/srep33956RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes (Journal article)
McDermott, B., Ellis, S., Bou-Gharios, G., Clegg, P., & Tew, S. (2016). RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes. Osteoarthritis and Cartilage, 24(7), 1263-1273. doi:10.1016/j.joca.2016.01.988Proteomic differences between native and tissue-engineered tendon and ligament (Journal article)
Kharaz, Y. A., Tew, S. R., Peffers, M., Canty-Laird, E. G., & Comerford, E. (2016). Proteomic differences between native and tissue-engineered tendon and ligament. PROTEOMICS, 16(10), 1547-1556. doi:10.1002/pmic.201500459Modest, transient high-glucose exposure has the potential to alter DNA methylation profiles of musculoskeletal cells and induce DNA damage (Conference Paper)
Tregilgas, L., Reynard, L., Tew, S., Loughlin, J., Clegg, P., & Canty-Laird, E. (2016). Modest, transient high-glucose exposure has the potential to alter DNA methylation profiles of musculoskeletal cells and induce DNA damage. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A14). Retrieved from https://www.webofscience.com/2015
PI-3K signalling is a consensus pathway in musculoskeletal de- and re-differentiation (Conference Paper)
Mueller, A. J., Tew, S. R., Canty-Laird, E. G., & Clegg, P. D. (2015). PI-3K signalling is a consensus pathway in musculoskeletal de- and re-differentiation. In Bone and Joint Journal Vol. 97-B. British Editorial Society of Bone and Joint Surgery. Retrieved from http://www.bjjprocs.boneandjoint.org.uk/content/97-B/SUPP_11/8Magnetic resonance compositional imaging of articular cartilage: What can we expect in veterinary medicine? (Journal article)
Hontoir, F., Clegg, P., Nisolle, J. -F., Tew, S., & Vandeweerd, J. -M. (2015). Magnetic resonance compositional imaging of articular cartilage: What can we expect in veterinary medicine?. VETERINARY JOURNAL, 205(1), 11-20. doi:10.1016/j.tvjl.2015.04.035The effects of adiopokines on canine cruciate ligament and meniscus (Journal article)
Saengsoi, W., Tew, S., Janssens, B., Bing, C., Comerford, E., & German, A. (2015). The effects of adiopokines on canine cruciate ligament and meniscus. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 96(2), A19. Retrieved from https://www.webofscience.com/2014
Transcriptome‐Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes (Journal article)
Tew, S., McDermott, B., Fentem, R. B., Peffers, M., & Clegg, P. (2014). Transcriptome‐Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes. Arthritis and Rheumatology, 66(11), 3052-3061. doi:10.1002/art.38849Identifying key proteoglycans in different regions of canine cranial cruciate ligament (Conference Paper)
Allaith, M. S., Tew, S., Clegg, P. D., Laird, E., Comerford, E., & Caterson, B. (2014). Identifying key proteoglycans in different regions of canine cranial cruciate ligament. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 95 (pp. A2-A3). Retrieved from https://www.webofscience.com/A COMPARISON OF THE EXTRACELLULAR MATRIX COMPOSITION OF TENDON/LIGAMENT TISSUE AND TISSUE ENGINEERED TENDON AND LIGAMENT CONSTRUCT (Conference Paper)
Kharaz, Y. A., Tew, S., Canty-Laird, E., & Comerford, E. (2014). A COMPARISON OF THE EXTRACELLULAR MATRIX COMPOSITION OF TENDON/LIGAMENT TISSUE AND TISSUE ENGINEERED TENDON AND LIGAMENT CONSTRUCT. In OSTEOARTHRITIS AND CARTILAGE Vol. 22 (pp. S313). doi:10.1016/j.joca.2014.02.580THE IDENTIFICATION AND DISTRIBUTION OF KEY PROTEOGLYCANS IN CANINE CRUCIATE LIGAMENT (Conference Paper)
Allaith, S., Clegg, P. D., Canty-Laird, E. G., Tew, S., Caterson, B., & Comerford, E. (2014). THE IDENTIFICATION AND DISTRIBUTION OF KEY PROTEOGLYCANS IN CANINE CRUCIATE LIGAMENT. In OSTEOARTHRITIS AND CARTILAGE Vol. 22 (pp. S332-S333). doi:10.1016/j.joca.2014.02.614BIOCHEMICAL COMPOSITION OF CARTILAGE WITH NATURALLY OCCURRING DEFECTS IN THE OVINE FEMORO-TIBIAL JOINT (Conference Paper)
Matagne, A., Clegg, P., Tew, S., Kirschvink, N., Gustin, P., Meirlaen, P., . . . Vandeweerd, J. M. (2014). BIOCHEMICAL COMPOSITION OF CARTILAGE WITH NATURALLY OCCURRING DEFECTS IN THE OVINE FEMORO-TIBIAL JOINT. In OSTEOPOROSIS INTERNATIONAL Vol. 25 (pp. S192). Retrieved from https://www.webofscience.com/Biochemical comparison of the extracellular matrix composition of tendon/ligament tissue and tissue engineered tendon/ligament constructs (Conference Paper)
Kharaz, A. K. A., Tew, S. R. T., Laird, E. G. L., & Comerford, E. C. (2014). Biochemical comparison of the extracellular matrix composition of tendon/ligament tissue and tissue engineered tendon/ligament constructs. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 95 (pp. A4-A5). Retrieved from https://www.webofscience.com/2013
TRANSCRIPTOMIC SIGNATURES IN CARTILAGE AGEING (Conference Paper)
Peffers, M. J., Tew, S. R., & Clegg, P. D. (2013). TRANSCRIPTOMIC SIGNATURES IN CARTILAGE AGEING. In OSTEOARTHRITIS AND CARTILAGE Vol. 21 (pp. S9). doi:10.1016/j.joca.2013.02.040Myocardial cytokine expression in dogs with systemic and naturally occurring cardiac diseases (Journal article)
Fonfara, S., Hetzel, U., Tew, S. R., Cripps, P., Dukes-McEwan, J., & Clegg, P. D. (2013). Myocardial cytokine expression in dogs with systemic and naturally occurring cardiac diseases. AMERICAN JOURNAL OF VETERINARY RESEARCH, 74(3), 408-416. doi:10.2460/ajvr.74.3.408Expression of matrix metalloproteinases, their inhibitors, and lysyl oxidase in myocardial samples from dogs with end-stage systemic and cardiac diseases (Journal article)
Fonfara, S., Hetzel, U., Tew, S. R., Cripps, P., Dukes-McEwan, J., & Clegg, P. D. (2013). Expression of matrix metalloproteinases, their inhibitors, and lysyl oxidase in myocardial samples from dogs with end-stage systemic and cardiac diseases. AMERICAN JOURNAL OF VETERINARY RESEARCH, 74(2), 216-223. doi:10.2460/ajvr.74.2.216CANINE DILATED CARDIOMYOPATHY IS ASSOCIATED WITH INCREASED MYOCARDIAL ICAM1 EXPRESSION (Conference Paper)
Fonfara, S., Hetzel, U., Oyama, M., Tew, S. R., & Kipar, A. (2013). CANINE DILATED CARDIOMYOPATHY IS ASSOCIATED WITH INCREASED MYOCARDIAL ICAM1 EXPRESSION. In JOURNAL OF COMPARATIVE PATHOLOGY Vol. 148 (pp. 99). doi:10.1016/j.jcpa.2012.11.213Gene expression alterations in tendon-derived cells after serial passage in 2D cell culture (Conference Paper)
Mueller, A. J., Tew, S. R., Vasieva, O., Clegg, P. D., & Canty-Laird, E. G. (2013). Gene expression alterations in tendon-derived cells after serial passage in 2D cell culture. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 94 (pp. A4-A5). Retrieved from https://www.webofscience.com/Investigating the post-transcriptional regulatory mechanisms controlling SOX9 in chondrocytes (Conference Paper)
McDermott, B. T., Clegg, P. D., & Tew, S. R. (2013). Investigating the post-transcriptional regulatory mechanisms controlling SOX9 in chondrocytes. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 94 (pp. A14-A15). Retrieved from https://www.webofscience.com/2012
Increased blood mRNA expression of inflammatory and anti-fibrotic markers in dogs with congestive heart failure (Journal article)
Fonfara, S., Tew, S. R., Cripps, P., Dukes-McEwan, J., & Clegg, P. D. (2012). Increased blood mRNA expression of inflammatory and anti-fibrotic markers in dogs with congestive heart failure. RESEARCH IN VETERINARY SCIENCE, 93(2), 879-885. doi:10.1016/j.rvsc.2011.10.020GLOBAL GENE EXPRESSION ANALYSIS OF DEDIFFERENTIATED CHONDROCYTES (Conference Paper)
Mueller, A. J., Laird, E. G., Tew, S. R., & Clegg, P. D. (2012). GLOBAL GENE EXPRESSION ANALYSIS OF DEDIFFERENTIATED CHONDROCYTES. In RHEUMATOLOGY Vol. 51 (pp. 49). Retrieved from https://www.webofscience.com/Fat pad-derived mesenchymal stem cells as a potential source for cell-based adipose tissue repair strategies (Journal article)
Khan, W. S., Adesida, A. B., Tew, S. R., Longo, U. G., & Hardingham, T. E. (2012). Fat pad-derived mesenchymal stem cells as a potential source for cell-based adipose tissue repair strategies. CELL PROLIFERATION, 45(2), 111-120. doi:10.1111/j.1365-2184.2011.00804.xSUBSTANTIAL ALTERATION OF POST-TRANSCRIPTIONAL GENE CONTROL IN CHONDROCYTES FROM OSTEOARTHRITIC JOINTS (Journal article)
Tew, S. R., McDermott, B., Vasieva, O., & Clegg, P. D. (2012). SUBSTANTIAL ALTERATION OF POST-TRANSCRIPTIONAL GENE CONTROL IN CHONDROCYTES FROM OSTEOARTHRITIC JOINTS. OSTEOARTHRITIS AND CARTILAGE, 20, S43. doi:10.1016/j.joca.2012.02.582MYOCARDIAL ICAM1 MRNA IS INCREASED IN CANINE DILATED CARDIOMYOPATHY. (Journal article)
Fonfara, S., Oyama, M. A., Cripps, P., Tew, S. R., & Clegg, P. D. (2012). MYOCARDIAL ICAM1 MRNA IS INCREASED IN CANINE DILATED CARDIOMYOPATHY.. JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(3), 716. Retrieved from https://www.webofscience.com/2011
Leptin Expression in Dogs with Cardiac Disease and Congestive Heart Failure (Journal article)
Fonfara, S., Hetzel, U., Tew, S. R., Dukes-Mcewan, J., Cripps, P., & Clegg, P. D. (2011). Leptin Expression in Dogs with Cardiac Disease and Congestive Heart Failure. JOURNAL OF VETERINARY INTERNAL MEDICINE, 25(5), 1017-1024. doi:10.1111/j.1939-1676.2011.00782.xPost-transcriptional gene regulation following exposure of osteoarthritic human articular chondrocytes to hyperosmotic conditions (Journal article)
Tew, S. R., Vasieva, O., Peffers, M. J., & Clegg, P. D. (2011). Post-transcriptional gene regulation following exposure of osteoarthritic human articular chondrocytes to hyperosmotic conditions. OSTEOARTHRITIS AND CARTILAGE, 19(8), 1036-1046. doi:10.1016/j.joca.2011.04.015Analysis of Post Transcriptional Regulation of SOX9 mRNA During <i>In Vitro</i> Chondrogenesis (Journal article)
Tew, S. R., & Clegg, P. D. (2011). Analysis of Post Transcriptional Regulation of SOX9 mRNA During <i>In Vitro</i> Chondrogenesis. TISSUE ENGINEERING PART A, 17(13-14), 1801-1807. doi:10.1089/ten.tea.2010.0579Development of a luciferase-based reporter system to analyse post-transcriptional gene regulation in osteoarthritis (Conference Paper)
McDermott, B. T., Tew, S. R., & Clegg, P. D. (2011). Development of a luciferase-based reporter system to analyse post-transcriptional gene regulation in osteoarthritis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 92 (pp. A31-A32). Retrieved from https://www.webofscience.com/LEPTIN EXPRESSION IN BLOOD AND MYOCARDIAL SAMPLES OF DOGS WITH CARDIAC DISEASE (Journal article)
Fonfara, S., Hetzel, U., Tew, S. R., Dukes-McEwan, J., & Clegg, P. D. (2011). LEPTIN EXPRESSION IN BLOOD AND MYOCARDIAL SAMPLES OF DOGS WITH CARDIAC DISEASE. JOURNAL OF VETERINARY INTERNAL MEDICINE, 25(3), 649-650. Retrieved from https://www.webofscience.com/Optimisation of osteogenic and chondrogenic differentiation potential using clonal mesenchymal stem cell populations derived from synovial fat pad (Conference Paper)
Khan, W. S., Tew, S. R., Adesida, A. B., Andrew, J. Q., & Hardingham, T. E. (2011). Optimisation of osteogenic and chondrogenic differentiation potential using clonal mesenchymal stem cell populations derived from synovial fat pad. In European Cells and Materials Vol. 22 (pp. 56).Regulation of SOX9 mRNA decay correlates with overall SOX9 levels in human articular chondrocytes: evidence for the involvement of the RNA binding protein tristetraprolin (Conference Paper)
Tew, S. R., & Clegg, P. D. (2011). Regulation of SOX9 mRNA decay correlates with overall SOX9 levels in human articular chondrocytes: evidence for the involvement of the RNA binding protein tristetraprolin. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 92 (pp. A31). Retrieved from https://www.webofscience.com/2010
Post-transcriptional gene regulation in chondrocytes (Journal article)
Tew, S. R., & Clegg, P. D. (2010). Post-transcriptional gene regulation in chondrocytes. BIOCHEMICAL SOCIETY TRANSACTIONS, 38, 1627-1631. doi:10.1042/BST0381627Regulation of SOX9 in normal and osteoarthritic equine articular chondrocytes by hyperosmotic loading (Journal article)
Peffers, M. J., Milner, P. I., Tew, S. R., & Clegg, P. D. (2010). Regulation of SOX9 in normal and osteoarthritic equine articular chondrocytes by hyperosmotic loading. OSTEOARTHRITIS AND CARTILAGE, 18(11), 1502-1508. doi:10.1016/j.joca.2010.08.011CYCLICAL HYPEROSMOLAR LOADING OF HUMAN ARTICULAR CHONDROCYTES INCREASES SOX9 GENE EXPRESSION AND P38 SIGNALLING IS REQUIRED (Conference Paper)
Peffers, M. J., Clegg, P. D., Tew, S., & Milne, P. I. (2010). CYCLICAL HYPEROSMOLAR LOADING OF HUMAN ARTICULAR CHONDROCYTES INCREASES SOX9 GENE EXPRESSION AND P38 SIGNALLING IS REQUIRED. In OSTEOARTHRITIS AND CARTILAGE Vol. 18 (pp. S125). doi:10.1016/S1063-4584(10)60306-8IDENTIFICATION OF POST-TRANSCRIPTIONALLY REGULATED GENES FOLLOWING EXPOSURE OF HUMAN ARTICULAR CHONDROCYTES TO HYPEROSMOTIC CONDITIONS (Conference Paper)
Tew, S. R., & Clegg, P. D. (2010). IDENTIFICATION OF POST-TRANSCRIPTIONALLY REGULATED GENES FOLLOWING EXPOSURE OF HUMAN ARTICULAR CHONDROCYTES TO HYPEROSMOTIC CONDITIONS. In OSTEOARTHRITIS AND CARTILAGE Vol. 18 (pp. S99). doi:10.1016/S1063-4584(10)60237-3Bone Marrow-Derived Mesenchymal Stem Cells Express the Pericyte Marker 3G5 in Culture and Show Enhanced Chondrogenesis in Hypoxic Conditions (Journal article)
Khan, W. S., Adesida, A. B., Tew, S. R., Lowe, E. T., & Hardingham, T. E. (2010). Bone Marrow-Derived Mesenchymal Stem Cells Express the Pericyte Marker 3G5 in Culture and Show Enhanced Chondrogenesis in Hypoxic Conditions. JOURNAL OF ORTHOPAEDIC RESEARCH, 28(6), 834-840. doi:10.1002/jor.21043Bone and Cartilage Biology - lessons from development, vascular interactions and dysplasias (Conference Paper)
Brakspear, K., Culley, K., Davidson, R., Sofat, N., & Tew, S. (2010). Bone and Cartilage Biology - lessons from development, vascular interactions and dysplasias. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 91 (pp. A1-A14). Retrieved from https://www.webofscience.com/CYTOKINE AND MATRIX METALLOPROTEINASE EXPRESSION IN BLOOD SAMPLES OF DOGS WITH CONGESTIVE HEART FAILURE (Conference Paper)
Fonfara, S., Tew, S., Clegg, P., & Dukes-McEwan, J. (2010). CYTOKINE AND MATRIX METALLOPROTEINASE EXPRESSION IN BLOOD SAMPLES OF DOGS WITH CONGESTIVE HEART FAILURE. In JOURNAL OF VETERINARY INTERNAL MEDICINE Vol. 24 (pp. 671). Retrieved from https://www.webofscience.com/Clonal esenchymal stem cell populations derived from the synovial fat pad exhibit a similar cell surface characterisation profile but variable osteogenic and chondrogenic differentiation potential (Conference Paper)
Khan, W. S., Tew, S. R., Adesida, A., Andrew, J. G., & Hardingham, T. E. (2010). Clonal esenchymal stem cell populations derived from the synovial fat pad exhibit a similar cell surface characterisation profile but variable osteogenic and chondrogenic differentiation potential. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 91 (pp. A19-A20). Retrieved from https://www.webofscience.com/Hyperosmotic stimulation of chondrocytes leads to differential post transcriptional regulation of SOX9 and COL2A1 mRNA: potential role for the RNA binding proteins TTP and AUF1? (Conference Paper)
Tew, S. R., & Clegg, P. D. (2010). Hyperosmotic stimulation of chondrocytes leads to differential post transcriptional regulation of SOX9 and COL2A1 mRNA: potential role for the RNA binding proteins TTP and AUF1?. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 91 (pp. A38-A39). Retrieved from https://www.webofscience.com/The MEK-ERK signalling pathway plays a role in SOX9 gene expression in human articular chondrocytes (Conference Paper)
Peffers, M. J., Tew, S. R., Milner, P. I., & Clegg, P. D. (2010). The MEK-ERK signalling pathway plays a role in SOX9 gene expression in human articular chondrocytes. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 91 (pp. A38). Retrieved from https://www.webofscience.com/2009
Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes (Journal article)
Tew, S. R., Peffers, M. J., McKay, T. R., Lowe, E. T., Khan, W. S., Hardingham, T. E., & Clegg, P. D. (2009). Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 297(4), C898-C906. doi:10.1152/ajpcell.00571.2008The epitope characterisation and the osteogenic differentiation potential of human fat pad-derived stem cells is maintained with ageing in later life (Journal article)
Khan, W. S., Adesida, A. B., Tew, S. K., Andrew, J. G., & Hardingham, T. E. (2009). The epitope characterisation and the osteogenic differentiation potential of human fat pad-derived stem cells is maintained with ageing in later life. INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 40(2), 150-157. doi:10.1016/j.injury.2008.05.029The influence of donor and hypoxic conditions on the assembly of cartilage matrix by osteoarthritic human articular chondrocytes on Hyalograft matrices (Journal article)
Katopodi, T., Tew, S. R., Clegg, P. D., & Hardingham, T. E. (2009). The influence of donor and hypoxic conditions on the assembly of cartilage matrix by osteoarthritic human articular chondrocytes on Hyalograft matrices. BIOMATERIALS, 30(4), 535-540. doi:10.1016/j.biomaterials.2008.09.064Rapid stimulation of p38 MAPK and upregulation of SOX9 mRNA following hyperosmotic treatment of human articular chondrocytes (Conference Paper)
Tew, S. R., Hardingham, T. E., & Clegg, P. D. (2009). Rapid stimulation of p38 MAPK and upregulation of SOX9 mRNA following hyperosmotic treatment of human articular chondrocytes. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 90 (pp. A132). Retrieved from https://www.webofscience.com/2008
SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription (Journal article)
Tew, S. R., Pothacharoen, P., Katopod, T., & Hardingham, T. E. (2008). SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription. BIOCHEMICAL JOURNAL, 414, 231-236. doi:10.1042/BJ20080262Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2 (Journal article)
Khan, W. S., Tew, S. R., Adesida, A. B., & Hardingham, T. E. (2008). Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2. ARTHRITIS RESEARCH & THERAPY, 10(4). doi:10.1186/ar2448BSMB Autumn 2007 meeting report - Shaping and sensing the extracellular matrix (Journal article)
Kuiper, N., Gabriel, N., Griffiths, S., & Tew, S. (2008). BSMB Autumn 2007 meeting report - Shaping and sensing the extracellular matrix. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 89(3), A1-A4. doi:10.1111/j.1365-2613.2007.00572.xCellular methods in cartilage research: Primary human chondrocytes in culture and chondrogenesis in human bone marrow stem cells (Journal article)
Tew, S. R., Murdoch, A. D., Rauchenberg, R. P., & Hardingham, T. E. (2008). Cellular methods in cartilage research: Primary human chondrocytes in culture and chondrogenesis in human bone marrow stem cells. METHODS, 45(1), 2-9. doi:10.1016/j.ymeth.2008.01.006Notch signaling through jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis (Journal article)
Oldershaw, R. A., Tew, S. R., Russell, A. M., Meade, K., Hawkins, R., McKay, T. R., . . . Hardingham, T. E. (2008). Notch signaling through jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis. STEM CELLS, 26(3), 666-674. doi:10.1634/stemcells.2007-0806Bone marrow derived mesenchymal stem cells express pericyte markers in culture and show enhanced chondrogenesis in hypoxic conditions (Conference Paper)
Khan, W. S., Adesida, A. B., Tew, S. R., Andrew, J. G., & Hardingham, T. E. (2008). Bone marrow derived mesenchymal stem cells express pericyte markers in culture and show enhanced chondrogenesis in hypoxic conditions. In CALCIFIED TISSUE INTERNATIONAL Vol. 83 (pp. 17). Retrieved from https://www.webofscience.com/Osmotic regulation of SOX9 in human articular chondrocytes through p38 MAPK mediated mRNA stabilization (Conference Paper)
Tew, S. R., Mckay, T., Lowe, E., Clegg, P. D., & Hardingham, T. E. (2008). Osmotic regulation of SOX9 in human articular chondrocytes through p38 MAPK mediated mRNA stabilization. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 89 (pp. A26). Retrieved from https://www.webofscience.com/Vascular pericytes in human infrapatellar fat pad tissue are candidate adult stem cells (Journal article)
Khan, W. S., Tew, S. R., Adesida, A. B., & Hardingham, T. E. (2008). Vascular pericytes in human infrapatellar fat pad tissue are candidate adult stem cells. Arthritis Res Ther, 10, R74.2007
SOX9 transduction of a human chondrocytic cell line identifies novel genes regulated in primary human chondrocytes and in osteoarthritis (Journal article)
Tew, S. R., Clegg, P. D., Brew, C. J., Redmond, C. M., & Hardingham, T. E. (2007). SOX9 transduction of a human chondrocytic cell line identifies novel genes regulated in primary human chondrocytes and in osteoarthritis. ARTHRITIS RESEARCH & THERAPY, 9(5). doi:10.1186/ar2311Cell Culture in Tissue Engineering (Chapter)
Hardingham, T. E., Kielty, C. M., Canfield, A. E., Tew, S. R., Ball, S. G., Turner, N. J., & Ratcliffe, K. E. (2007). Cell Culture in Tissue Engineering. In Unknown Book (pp. 523-541). Wiley. doi:10.1002/9780470723791.ch28Tissue regeneration: Formation and repair of the extracellular matrix (Journal article)
Hardingham, T., Tew, S., & Murdoch, A. (2007). Tissue regeneration: Formation and repair of the extracellular matrix. The Biochemist, 29(1), 16-18. doi:10.1042/bio02901016Cell culture in tissue engineering (Chapter)
Hardingham, T. E., Kielty, C. M., Canfield, A. E., Tew, S. R., Ball, S. G., Turner, N. J., & Ratcliffe, K. E. (2007). Cell culture in tissue engineering. In G. Stacey, & J. Davis (Eds.), Biological Medicines from Cell Culture (pp. 525-543). London: John Wiley and Sons.In situ detection of cell death in articular cartilage. (Journal article)
Redman, S. N., Khan, I. M., Tew, S. R., & Archer, C. W. (2007). In situ detection of cell death in articular cartilage.. Methods in molecular medicine, 135, 183-199. doi:10.1007/978-1-59745-401-8_11Interleukin 1β activation of p38 MAPK in human osteoarthritic articular chondrocytes increases SOX9 expression and is dependent on cytoskeletal organisation (Conference Paper)
Tew, S. R., & Hardingham, T. E. (2007). Interleukin 1β activation of p38 MAPK in human osteoarthritic articular chondrocytes increases SOX9 expression and is dependent on cytoskeletal organisation. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 88 (pp. A53-A54). Retrieved from https://www.webofscience.com/2006
Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization (Journal article)
Tew, S. R., & Hardingham, T. E. (2006). Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(51), 39471-39479. doi:10.1074/jbc.M604322200Cartilage, SOX9 and notch signals in chondrogenesis (Journal article)
Hardingham, T. E., Oldershaw, R. A., & Tew, S. R. (2006). Cartilage, SOX9 and notch signals in chondrogenesis. JOURNAL OF ANATOMY, 209(4), 469-480. doi:10.1111/j.1469-7580.2006.00630.xControl of chondrogenesis and the assembly of cartilage matrix (Conference Paper)
Hardingham, T., Tew, S., Oldershaw, R., & Murdoch, A. (2006). Control of chondrogenesis and the assembly of cartilage matrix. In JOURNAL OF ANATOMY Vol. 209 (pp. 573). Retrieved from https://www.webofscience.com/SOX9 can be superinduced by cycloheximide during the early stages of human articular chondrocyte redifferentiation by a p38 MAPK-dependent mechanism (Conference Paper)
Tew, S. R., & Hardingham, T. E. (2006). SOX9 can be superinduced by cycloheximide during the early stages of human articular chondrocyte redifferentiation by a p38 MAPK-dependent mechanism. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 87 (pp. A54-A55). Retrieved from https://www.webofscience.com/2005
Co-expression of SOX 9 and SOX 6 enhances collagen 2 gene expression (Journal article)
Lunj, S., Duxbury, R., Russell, A. M., Li, Y., Tew, S. R., Hardingham, T. E., . . . Hawkins, R. E. (2005). Co-expression of SOX 9 and SOX 6 enhances collagen 2 gene expression. European Cells and Materials, 10(SUPPL.2), 52.British Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK (Conference Paper)
British Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK (2005). In International Journal of Experimental Pathology Vol. 86. Wiley. doi:10.1111/j.0959-9673.2005.00426.xMicroarray analysis of SOX9-transduced chondrocytic cells identifies genes that are regulated in osteoarthritis (Conference Paper)
Tew, S. R., Clegg, P. D., Brew, C. J., & Hardingham, T. E. (2005). Microarray analysis of SOX9-transduced chondrocytic cells identifies genes that are regulated in osteoarthritis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 86 (pp. A86-A87). Retrieved from https://www.webofscience.com/Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes (Journal article)
Tew, S. R., Li, Y., Pothacharoen, P., Tweats, L. M., Hawkins, R. E., & Hardingham, T. E. (2005). Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes. OSTEOARTHRITIS AND CARTILAGE, 13(1), 80-89. doi:10.1016/j.joca.2004.10.011Stimulation of cartilage matrix synthesis by human articular chondrocytes using SOX9 transfection and hypoxic culture conditions (Conference Paper)
Tew, S. R., Li, Y., Tweats, L. M., Hawkins, R. E., & Hardingham, T. E. (2005). Stimulation of cartilage matrix synthesis by human articular chondrocytes using SOX9 transfection and hypoxic culture conditions. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 86 (pp. A5-A6). Retrieved from https://www.webofscience.com/2004
Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9 (Journal article)
Li, Y., Tew, S. R., Russell, A. M., Gonzalez, K. R., Hardingham, T. E., & Hawkins, R. E. (2004). Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9. TISSUE ENGINEERING, 10(3-4), 575-584. doi:10.1089/107632704323061933Transduction of human articular chondrocytes with adenoviral, retroviral and lentiviral vectors and the effects of enhanced expression of SOX9 (Journal article)
Li, Y., Tew, S. R., Russell, A. M., Gonzalez, K., Hardingham, T. E., & Hawkins, R. E. (2004). Transduction of human articular chondrocytes with adenoviral, retroviral and lentiviral vectors and the effects of enhanced expression of SOX9. Tissue Engineering, 10, 375-384.2003
SOX9 transduction and TGFβ-3 treatment of late passage human articular chondrocytes in pellet culture potentiates cartilage matrix formation (Conference Paper)
Tew, S. R., Li, Y., Tweats, L. M., Katopodi, T., Hawkins, R. E., & Hardingham, T. E. (2003). SOX9 transduction and TGFβ-3 treatment of late passage human articular chondrocytes in pellet culture potentiates cartilage matrix formation. In European Cells and Materials Vol. 6 (pp. 53).2002
Efficient transduction of human chondrocytes with retroviral, lentiviral and adenoviral vectors (Conference Paper)
Li, Y., Russell, A. M., Tew, S. R., Hardingham, T. E., & Hawkins, R. E. (2002). Efficient transduction of human chondrocytes with retroviral, lentiviral and adenoviral vectors. In Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products (pp. 103).Enhanced chondrocyte redifferentiation after SOX9 transduction (Conference Paper)
Tew, S. R., Li, Y., Russell, A., Prince, J. M., Hawkins, R., & Hardingham, T. E. (2002). Enhanced chondrocyte redifferentiation after SOX9 transduction. In Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products (pp. 48).The re-expression of chondrocytic phenotype by passaged human articular chondrocytes is improved by viral transduction of SOX9 (Conference Paper)
Tew, S. R., Li, Y., Russell, A. M., Prince, J. M., Hawkins, R. E., & Hardingham, T. E. (2002). The re-expression of chondrocytic phenotype by passaged human articular chondrocytes is improved by viral transduction of SOX9. In European Cells and Materials Vol. 4 (pp. 88).Tissue engineering: chondrocytes and cartilage (Journal article)
Hardingham, T., Tew, S., & Murdoch, A. (2002). Tissue engineering: chondrocytes and cartilage. ARTHRITIS RESEARCH & THERAPY, 4, S63-S68. doi:10.1186/ar5612001
SOX gene expression and growth factor responses of human chondrocyte cell lines in monolayer culture (Conference Paper)
Tew, S. R., Goldring, M. B., & Hardingham, T. E. (2001). SOX gene expression and growth factor responses of human chondrocyte cell lines in monolayer culture. In International Journal of Experimental Pathology Vol. 82.Differences in repair responses between immature and mature cartilage (Journal article)
Tew, S., Redman, S., Kwan, A., Walker, E., Khan, I., Dowthwaite, G., . . . Archer, C. W. (2001). Differences in repair responses between immature and mature cartilage. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, (391), S142-S152. Retrieved from https://www.webofscience.com/2000
The reactions of articular cartilage to experimental wounding - Role of apoptosis (Journal article)
Tew, S. R., Kwan, A. P. L., Hann, A., Thomson, B. M., & Archer, C. W. (2000). The reactions of articular cartilage to experimental wounding - Role of apoptosis. ARTHRITIS AND RHEUMATISM, 43(1), 215-225. doi:3.0.CO;2-X">10.1002/1529-0131(200001)43:1<215::AID-ANR26>3.0.CO;2-XDOI: 10.1002/1529-0131(200001)43:1<215::AID-ANR26>3.0.CO;2-X
The reactions of articular cartilage to experimental wounding: role of apoptosis. (Journal article)
Tew, S. R., Kwan, A. P., Hann, A., Thomson, B. M., & Archer, C. W. (2000). The reactions of articular cartilage to experimental wounding: role of apoptosis.. Arthritis and rheumatism, 43(1), 215-225. doi:3.0.co;2-x">10.1002/1529-0131(200001)43:1<215::aid-anr26>3.0.co;2-xDOI: 10.1002/1529-0131(200001)43:1<215::aid-anr26>3.0.co;2-x