Professor Peter Clegg MA Vet MB PhD CertEO DipECVS FRCVS Professor Musculoskeletal & Ageing Science Work email P.D.Clegg@liverpool.ac.uk About Research Publications Teaching Professional Activities Teaching Modules for 2023-24 GRAND CHALLENGES IN BIOLOGY Module code: LIFE105 Role: Teaching Supervised ThesesA descriptive study of the ultrastucture of the equine superficial digital flexor tendonA systems biology approach to musculoskeletal tissue engineering: transcriptomic and proteomic analysis of cartilage and tendon cellsAn Investigation into the Significance of Tissue pH and Biofilms on Wound HealingAn investigation into the use of hoof balance metrics to test the reliability of a commonly used foot trimming protocol and their association with biomechanics and pathologies of the equine digit.Defining the role and mechanisms of miRNAs in cartilage ageing and diseaseDevelopment of Sustained Release, Anti-Cytokine Short Interfering RNA (siRNA) Therapy for Equine OsteoarthritisHoof shape and loading in sound and lame horses; how this is influenced by farrieryInvestigating the effects of glucose exposure on synoviocytes and chondrocytes as a model for musculoskeletal ageingPROTEOMIC AND METABOLOMIC SIGNATURES OF ARTHROPATHIESProteomic analysis of tendons at different risk of injury.TGF-β mediated synthesis of degradation-resistant collagen (I) homotrimer in musculoskeletal cellsTendon and ligament stem cells and their nicheThe emerging problem of antimicrobial resistance in horses: Investigating faecal carriage and environmental contamination with resistant Escherichia coli in equine hospitals and clinical infections with multidrug resistant bacteriaThe role of Nuclear Lamins in regulating the circadian molecular clockwork; daily oscillations and response to mechanical stimulation.Transcriptional Regulation of the Aggrecan GenemicroRNA:target interactions in tendinopathy