Professor Dharani Hapangama BSc(Hons) MBChB MD FRCOG

Research Overview

The human endometrium is a major theme underpinning my research. My group focuses on the understanding of three dimensional organisation, function, and regeneration of the human endometrium in order to address major unmet clinical needs in gynaecology. We therefore centre our research on pathologies related to menstrual related symptoms, fertility/ early pregnancy and endometrial cancer.
Our research is funded by MRC, Wellbeing of Women’s, NIHR and North West Cancer Research.
Our research utilises a wide range of research methodology that has been established in our labs and supported by our expert national and international collaborators including; complex 3D in vitro tissue culturing; endometrial histology, immunohistochemistry, immuno-fluorescence, in situ hybridisation, laser capture micro-dissection, NMR, mass-spectroscopy and Raman spectroscopy, microarrays, RNA sequencing, imaging mass-spectroscopy as well as non-laboratory methods including systematic reviews and system biology.


Research grants

MRC (2021-2023): Identification of key transcriptional and functional differences in adenomyotic lesions to determine novel therapeutic targets

Wellbeing of Women’s (2018-2022); Metabolomics and cytokine profile analysis in biofluids to develop a non-invasive diagnostic test for ectopic pregnancy

NIHR/EME (2014-2022); EME Ulipristal versus conventional management of heavy menstrual bleeding (HMB; including uterine fibroids): a randomised controlled trial and exploration of mechanism of action (UCON trial)

NWCR (2021-2022): Acceptable and efficient early screening tests for endometrial cancer (AESTEC) Study

Royal Saudi PhD studentship (2021-2024): Human Fallopian Tubal mucosa: phenotypical and functional characterisation in health & disease

RLUH/LWH PhD Studentships (2021-2024): Understanding the pathogenesis and symptoms of deep infiltrating endometriosis invading the bowel.
LWH/Hewitt Centre MD/PhD Studentships;
(2020-2023): Endometrial contribution to recurrent reproductive failure
(2020-2023): Comparative Analysis of Biofluids Obtained in Early Pregnancy to Predict Adverse Pregnancy Outcomes
(2020-2023): Application of MASs Spectrometry and NMR based metabolomics analysis in female biofluids in patients undergoing IVF treatment at both extremes of response
(2019-2022): Improving the diagnosis and treatment of Endometrial Cancer
(2019-2022); Assessment of Urogenital Atrophy