2024
Marriott, A. E., Casewell, N. R., Lilley, E., Gutiérrez, J. -M., & Ainsworth, S. (2024). Improving <i>in vivo</i> assays in snake venom and antivenom research: A community discussion.. F1000Research, 13, 192. doi:10.12688/f1000research.148223.1DOI: 10.12688/f1000research.148223.1
Solano, G., Cunningham, S., Edge, R. J., Duran, G., Sanchez, A., Villalta, M., . . . Ainsworth, S. (2024). African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: evidence for increasing antivenom shelf life to aid in alleviating chronic shortages.. BMJ global health, 9(3), e014813. doi:10.1136/bmjgh-2023-014813DOI: 10.1136/bmjgh-2023-014813
Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins. (Journal article)
Khalek, I. S., Senji Laxme, R. R., Nguyen, Y. T. K., Khochare, S., Patel, R. N., Woehl, J., . . . Jardine, J. G. (2024). Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins.. Science translational medicine, 16(735), eadk1867. doi:10.1126/scitranslmed.adk1867DOI: 10.1126/scitranslmed.adk1867
Marriott, A., Casewell, N., Lilley, E., Gutiérrez, J. -M., & Ainsworth, S. (2024). Improving in vivo assays in snake venom and antivenom research: A community discussion. doi:10.12688/f1000research.148223.1DOI: 10.12688/f1000research.148223.1
2022
Menzies, S. K., Dawson, C. A., Crittenden, E., Edge, R. J., Hall, S. R., Alsolaiss, J., . . . Ainsworth, S. (2022). Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-13376-xDOI: 10.1038/s41598-022-13376-x
Alomran, N., Blundell, P., Alsolaiss, J., Crittenden, E., Ainsworth, S., Dawson, C. A., . . . Casewell, N. R. (2022). Exploring the Utility of Recombinant Snake Venom Serine Protease Toxins as Immunogens for Generating Experimental Snakebite Antivenoms. TOXINS, 14(7). doi:10.3390/toxins14070443DOI: 10.3390/toxins14070443
Exploring the utility of recombinantly expressed snake venom serine protease toxins as immunogens for generating experimental snakebite antivenoms (Preprint)
DOI: 10.1101/2022.05.07.491032
2021
Welcome to online-only production of <i>Parasitology</i> and future-proofing of the journal's academic standards (Journal article)
Stothard, J. R., Ainsworth, S., & Marriott, A. E. (2021). Welcome to online-only production of <i>Parasitology</i> and future-proofing of the journal's academic standards. PARASITOLOGY, 148(13), 1529-1531. doi:10.1017/S003118202100144XDOI: 10.1017/S003118202100144X
Virus-like particles displaying conserved toxin epitopes stimulate broadly reactive, polyspecific, murine antibody responses capable of snake venom recognition (Preprint)
DOI: 10.21203/rs.3.rs-1044937/v1
Alomran, N., Alsolaiss, J., Albulescu, L. -O., Crittenden, E., Harrison, R. A., Ainsworth, S., & Casewell, N. R. (2021). Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms.. PLoS neglected tropical diseases, 15(8), e0009659. doi:10.1371/journal.pntd.0009659DOI: 10.1371/journal.pntd.0009659
Rügen, N., Jenkins, T. P., Wielsch, N., Vogel, H., Hempel, B. -F., Süssmuth, R. D., . . . Tonk, M. (2021). Hexapod Assassins' Potion: Venom Composition and Bioactivity from the Eurasian Assassin Bug <i>Rhynocoris iracundus</i>.. Biomedicines, 9(7), 819. doi:10.3390/biomedicines9070819DOI: 10.3390/biomedicines9070819
Staton, G. J., Clegg, S. R., Ainsworth, S., Armstrong, S., Carter, S. D., Radford, A. D., . . . Evans, N. J. (2021). Dissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms. PLOS PATHOGENS, 17(3). doi:10.1371/journal.ppat.1009464DOI: 10.1371/journal.ppat.1009464
Kadam, P., Ainsworth, S., Sirur, F. M., Patel, D. C., Kuruvilla, J. J., & Majumdar, D. B. (2021). Approaches for implementing society-led community interventions to mitigate snakebite envenoming burden: The SHE-India experience.. PLoS neglected tropical diseases, 15(2), e0009078. doi:10.1371/journal.pntd.0009078DOI: 10.1371/journal.pntd.0009078
Convergent evolution of pain-inducing defensive venom components in spitting cobras (Journal article)
Kazandjian, T. D., Petras, D., Robinson, S. D., van Thiel, J., Greene, H. W., Arbuckle, K., . . . Casewell, N. R. (2021). Convergent evolution of pain-inducing defensive venom components in spitting cobras. SCIENCE, 371(6527), 386-+. doi:10.1126/science.abb9303DOI: 10.1126/science.abb9303
Animal derived antibodies should be considered alongside convalescent human plasma to deliver treatments for COVID-19 (Journal article)
Ainsworth, S., Menzies, S., & Pleass, R. (2020). Animal derived antibodies should be considered alongside convalescent human plasma to deliver treatments for COVID-19. doi:10.12688/wellcomeopenres.15990.1DOI: 10.12688/wellcomeopenres.15990.1
2020
A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite (Journal article)
Albulescu, L. -O., Xie, C., Ainsworth, S., Alsolaiss, J., Crittenden, E., Dawson, C. A., . . . Casewell, N. R. (2020). A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-19981-6DOI: 10.1038/s41467-020-19981-6
Walsh, T. R., Ainsworth, S., Armstrong, S., Hodgkinson, J., & Williams, D. (2020). Differences in the antibody response to adult Fasciola hepatica excretory/secretory products in experimentally and naturally infected cattle and sheep. Veterinary Parasitology, 109321. doi:10.1016/j.vetpar.2020.109321DOI: 10.1016/j.vetpar.2020.109321
Ainsworth, S., Menzies, S. K., Casewell, N. R., & Harrison, R. A. (2020). An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management.. PLoS neglected tropical diseases, 14(8), e0008579. doi:10.1371/journal.pntd.0008579DOI: 10.1371/journal.pntd.0008579
A therapeutic combination of two small molecule toxin inhibitors provides pancontinental preclinical efficacy against viper snakebite (Preprint)
DOI: 10.1101/2020.05.13.094599
Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite (Journal article)
Albulescu, L. -O., Hale, M. S., Ainsworth, S., Alsolaiss, J., Crittenden, E., Calvete, J. J., . . . Casewell, N. R. (2020). Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite. SCIENCE TRANSLATIONAL MEDICINE, 12(542). doi:10.1126/scitranslmed.aay8314DOI: 10.1126/scitranslmed.aay8314
Snake Venom Gland Organoids (Journal article)
Post, Y., Puschhof, J., Beumer, J., Kerkkamp, H. M., de Bakker, M. A. G., Slagboom, J., . . . Clevers, H. (2020). Snake Venom Gland Organoids. CELL, 180(2), 233-+. doi:10.1016/j.cell.2019.11.038DOI: 10.1016/j.cell.2019.11.038
2019
The time is now: a call for action to translate recent momentum on tackling tropical snakebite into sustained benefit for victims (Journal article)
Harrison, R. A., Casewell, N. R., Ainsworth, S. A., & Lalloo, D. G. (2019). The time is now: a call for action to translate recent momentum on tackling tropical snakebite into sustained benefit for victims. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 113(12), 834-837. doi:10.1093/trstmh/try134DOI: 10.1093/trstmh/try134
Preclinical validation of a repurposed metal chelator as a community-based therapeutic for hemotoxic snakebite (Preprint)
DOI: 10.1101/717280
Strategy for a globally coordinated response to a priority neglected tropical disease: Snakebite envenoming (Journal article)
Williams, D. J., Abul Faiz, M., Abela-Ridder, B., Ainsworth, S., Bulfone, T. C., Nickerson, A. D., . . . Warrell, D. A. (2019). Strategy for a globally coordinated response to a priority neglected tropical disease: Snakebite envenoming. PLOS NEGLECTED TROPICAL DISEASES, 13(2). doi:10.1371/journal.pntd.0007059DOI: 10.1371/journal.pntd.0007059
A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite (Journal article)
Albulescu, L. -O., Kazandjian, T., Slagboom, J., Bruyneel, B., Ainsworth, S., Alsolaiss, J., . . . Casewell, N. R. (2019). A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite. FRONTIERS IN PHARMACOLOGY, 10. doi:10.3389/fphar.2019.00848DOI: 10.3389/fphar.2019.00848
2018
Ainsworth, S., Slagboom, J., Alomran, N., Pla, D., Alhamdi, Y., King, S. I., . . . Casewell, N. R. (2018). The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms. COMMUNICATIONS BIOLOGY, 1. doi:10.1038/s42003-018-0039-1DOI: 10.1038/s42003-018-0039-1
Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins. (Journal article)
Vanzolini, K. L., Ainsworth, S., Bruyneel, B., Herzig, V., Seraus, M. G. L., Somsen, G. W., . . . Kool, J. (2018). Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins.. Toxicon : official journal of the International Society on Toxinology, 152, 1-8. doi:10.1016/j.toxicon.2018.06.080DOI: 10.1016/j.toxicon.2018.06.080
The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms. (Journal article)
Ainsworth, S., Petras, D., Engmark, M., Süssmuth, R. D., Whiteley, G., Albulescu, L. -O., . . . Calvete, J. J. (2018). The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms.. Journal of proteomics, 172, 173-189. doi:10.1016/j.jprot.2017.08.016DOI: 10.1016/j.jprot.2017.08.016
2017
Harrison, R. A., Oluoch, G. O., Ainsworth, S., Alsolaiss, J., Bolton, F., Arias, A. -S., . . . Casewell, N. R. (2017). Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa.. PLoS neglected tropical diseases, 11(10), e0005969. doi:10.1371/journal.pntd.0005969DOI: 10.1371/journal.pntd.0005969
Sadovskaya, I., Vinogradov, E., Courtin, P., Armalyte, J., Meyrand, M., Giaouris, E., . . . Chapot-Chartier, M. -P. (2017). Another Brick in the Wall: a Rhamnan Polysaccharide Trapped inside Peptidoglycan of <i>Lactococcus lactis</i>.. mBio, 8(5), e01303-e01317. doi:10.1128/mbio.01303-17DOI: 10.1128/mbio.01303-17
2016
Isolation of digital dermatitis treponemes from cattle hock skin lesions (Journal article)
Clegg, S. R., Bell, J., Ainsworth, S., Blowey, R. W., Bell, N. J., Carter, S. D., & Evans, N. J. (2016). Isolation of digital dermatitis treponemes from cattle hock skin lesions. VETERINARY DERMATOLOGY, 27(2), 106-E30. doi:10.1111/vde.12286DOI: 10.1111/vde.12286
2015
Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the <i>plasminogen</i> (<i>PLG</i>) gene (Journal article)
Ainsworth, S., Carter, S., Fisher, C., Dawson, J., Makrides, L., Nuttall, T., & Mason, S. L. (2015). Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the <i>plasminogen</i> (<i>PLG</i>) gene. ANIMAL GENETICS, 46(6), 707-710. doi:10.1111/age.12339DOI: 10.1111/age.12339
2014
The Lactococcus lactis plasmidome: much learnt, yet still lots to discover. (Journal article)
Ainsworth, S., Stockdale, S., Bottacini, F., Mahony, J., & van Sinderen, D. (2014). The Lactococcus lactis plasmidome: much learnt, yet still lots to discover.. FEMS microbiology reviews, 38(5), 1066-1088. doi:10.1111/1574-6976.12074DOI: 10.1111/1574-6976.12074
The plasmid complement of Lactococcus lactis UC509.9 encodes multiple bacteriophage resistance systems. (Journal article)
Ainsworth, S., Mahony, J., & van Sinderen, D. (2014). The plasmid complement of Lactococcus lactis UC509.9 encodes multiple bacteriophage resistance systems.. Applied and environmental microbiology, 80(14), 4341-4349. doi:10.1128/aem.01070-14DOI: 10.1128/aem.01070-14
Ainsworth, S., Sadovskaya, I., Vinogradov, E., Courtin, P., Guerardel, Y., Mahony, J., . . . van Sinderen, D. (2014). Differences in lactococcal cell wall polysaccharide structure are major determining factors in bacteriophage sensitivity.. mBio, 5(3), e00880-e00814. doi:10.1128/mbio.00880-14DOI: 10.1128/mbio.00880-14
2013
Bacteriophage orphan DNA methyltransferases: insights from their bacterial origin, function, and occurrence. (Journal article)
Murphy, J., Mahony, J., Ainsworth, S., Nauta, A., & van Sinderen, D. (2013). Bacteriophage orphan DNA methyltransferases: insights from their bacterial origin, function, and occurrence.. Applied and environmental microbiology, 79(24), 7547-7555. doi:10.1128/aem.02229-13DOI: 10.1128/aem.02229-13
Lytic infection of Lactococcus lactis by bacteriophages Tuc2009 and c2 triggers alternative transcriptional host responses. (Journal article)
Ainsworth, S., Zomer, A., Mahony, J., & van Sinderen, D. (2013). Lytic infection of Lactococcus lactis by bacteriophages Tuc2009 and c2 triggers alternative transcriptional host responses.. Applied and environmental microbiology, 79(16), 4786-4798. doi:10.1128/aem.01197-13DOI: 10.1128/aem.01197-13
Investigation of the relationship between lactococcal host cell wall polysaccharide genotype and 936 phage receptor binding protein phylogeny. (Journal article)
Mahony, J., Kot, W., Murphy, J., Ainsworth, S., Neve, H., Hansen, L. H., . . . van Sinderen, D. (2013). Investigation of the relationship between lactococcal host cell wall polysaccharide genotype and 936 phage receptor binding protein phylogeny.. Applied and environmental microbiology, 79(14), 4385-4392. doi:10.1128/aem.00653-13DOI: 10.1128/aem.00653-13
Ainsworth, S., Zomer, A., de Jager, V., Bottacini, F., van Hijum, S. A. F. T., Mahony, J., & van Sinderen, D. (2013). Complete Genome of Lactococcus lactis subsp. cremoris UC509.9, Host for a Model Lactococcal P335 Bacteriophage.. Genome announcements, 1(1), e00119-e00112. doi:10.1128/genomea.00119-12DOI: 10.1128/genomea.00119-12
2012
Phages of lactic acid bacteria: the role of genetics in understanding phage-host interactions and their co-evolutionary processes. (Journal article)
Mahony, J., Ainsworth, S., Stockdale, S., & van Sinderen, D. (2012). Phages of lactic acid bacteria: the role of genetics in understanding phage-host interactions and their co-evolutionary processes.. Virology, 434(2), 143-150. doi:10.1016/j.virol.2012.10.008DOI: 10.1016/j.virol.2012.10.008
