2022
Lenart, I., Truong, L. -H., Nguyen, D. D., Rasiukiene, O., Tsao, E., Armstrong, J., . . . Antoniou, A. N. (2022). Intrinsic Folding Properties of the HLA-B27 Heavy Chain Revealed by Single Chain Trimer Versions of Peptide-Loaded Class I Major Histocompatibility Complex Molecules. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.902135DOI: 10.3389/fimmu.2022.902135
Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review (Journal article)
Sivasudhan, E., Blake, N., Lu, Z., Meng, J., & Rong, R. (2022). Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review. CELLS, 11(4). doi:10.3390/cells11040741DOI: 10.3390/cells11040741
2021
Sivasudhan, E., Blake, N., Lu, Z. -L., Meng, J., & Rong, R. (2021). Dynamics of m6A RNA Methylome on the Hallmarks of Hepatocellular Carcinoma. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 9. doi:10.3389/fcell.2021.642443DOI: 10.3389/fcell.2021.642443
Iaconis, G., Jackson, B., Childs, K., Boyce, M., Goodbourn, S., Blake, N., . . . Seago, J. (2021). Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction. VIRUSES-BASEL, 13(4). doi:10.3390/v13040589DOI: 10.3390/v13040589
2019
Antoniou, A. N., Lenart, L., Kriston-Vizi, J., Lwawaki, T., Turmaine, M., McHugh, K., . . . Powis, S. J. (2019). Salmonella exploits HLA-B27 and host unfolded protein responses to promote intracellular replication. ANNALS OF THE RHEUMATIC DISEASES, 78(1), 74-82. doi:10.1136/annrheumdis-2018-213532DOI: 10.1136/annrheumdis-2018-213532
2018
Antoniou, A. N., Lenart, I., Kriston-Vizi, J., Iwawaki, T., Turmaine, M., McHugh, K., . . . Powis, S. J. (2018). Salmonella exploits HLA-B27 and host unfolded protein responses to promote intracellular replication. Annals of the Rheumatic Diseases, 78(1), 74-82. doi:10.1136/annrheumdis-2018-213532DOI: 10.1136/annrheumdis-2018-213532
2015
Halawi, M., Khan, N., & Blake, N. (2015). Identification of novel CD8+ T cell epitopes in human herpesvirus 6B U11 and U90. Immunity, Inflammation and Disease, 3(2), 118-131. doi:10.1002/iid3.55DOI: 10.1002/iid3.55
2010
Immune evasion by gammaherpesvirus genome maintenance proteins (Journal article)
Blake, N. (2010). Immune evasion by gammaherpesvirus genome maintenance proteins. Unknown Journal, 91(4), 829-846.
2009
Reduction in RNA Levels Rather than Retardation of Translation Is Responsible for the Inhibition of Major Histocompatibility Complex Class I Antigen Presentation by the Glutamic Acid-Rich Repeat of Herpesvirus Saimiri Open Reading Frame 73 (Journal article)
Gao, J., Coulson, J. M., Whitehouse, A., & Blake, N. (2009). Reduction in RNA Levels Rather than Retardation of Translation Is Responsible for the Inhibition of Major Histocompatibility Complex Class I Antigen Presentation by the Glutamic Acid-Rich Repeat of Herpesvirus Saimiri Open Reading Frame 73. JOURNAL OF VIROLOGY, 83(1), 273-282. doi:10.1128/JVI.01532-08DOI: 10.1128/JVI.01532-08
SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer (Journal article)
Moss, A. C., Jacobson, G. M., Walker, L. E., Blake, N. W., Marshall, E., & Coulson, J. M. (2009). SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer. CLINICAL CANCER RESEARCH, 15(1), 274-283. doi:10.1158/1078-0432.CCR-08-1163DOI: 10.1158/1078-0432.CCR-08-1163
2007
Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 Mimics Epstein-Barr Virus EBNA1 Immune Evasion through Central Repeat Domain Effects on Protein Processing (Journal article)
Kwun, H. J., da Silva, S. R., Shah, I. M., Blake, N., Moore, P. S., & Chang, Y. (2007). Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 Mimics Epstein-Barr Virus EBNA1 Immune Evasion through Central Repeat Domain Effects on Protein Processing. Journal of Virology, 81(15), 8225-8235. doi:10.1128/jvi.00411-07DOI: 10.1128/jvi.00411-07
Targeting tumour cells with defects in the MHC Class I antigen processing pathway with CD8+ T cells specific for hydrophobic TAP- and Tapasin-independent peptides: the requirement for directed access into the ER (Journal article)
Aladin, F., Lautscham, G., Humphries, E., Coulson, J., & Blake, N. (2007). Targeting tumour cells with defects in the MHC Class I antigen processing pathway with CD8+ T cells specific for hydrophobic TAP- and Tapasin-independent peptides: the requirement for directed access into the ER. CANCER IMMUNOLOGY IMMUNOTHERAPY, 56(8), 1143-1152. doi:10.1007/s00262-006-0263-2DOI: 10.1007/s00262-006-0263-2
2004
CD8 T Cell Recognition of Endogenously Expressed Epstein-Barr Virus Nuclear Antigen 1 (Journal article)
Lee, S. P., Brooks, J. M., Al-Jarrah, H., Thomas, W. A., Haigh, T. A., Taylor, G. S., . . . Blake, N. W. (2004). CD8 T Cell Recognition of Endogenously Expressed Epstein-Barr Virus Nuclear Antigen 1. The Journal of Experimental Medicine, 199(10), 1409-1420. doi:10.1084/jem.20040121DOI: 10.1084/jem.20040121
2003
Epstein–Barr virus nuclear antigen 1 (EBNA1) induced cytotoxicity in epithelial cells is associated with EBNA1 degradation and processing (Journal article)
Jones, R. J., Smith, L. J., Dawson, C. W., Haigh, T., Blake, N. W., & Young, L. S. (2003). Epstein–Barr virus nuclear antigen 1 (EBNA1) induced cytotoxicity in epithelial cells is associated with EBNA1 degradation and processing. Virology, 313(2), 663-676. doi:10.1016/s0042-6822(03)00392-1DOI: 10.1016/s0042-6822(03)00392-1
Impaired recovery of Epstein-Barr virus (EBV)—specific CD8+ T lymphocytes after partially T-depleted allogeneic stem cell transplantation may identify patients at very high risk for progressive EBV reactivation and lymphoproliferative disease (Journal article)
Meij, P., van Esser, J. W. J., Niesters, H. G. M., van Baarle, D., Miedema, F., Blake, N., . . . Gratama, J. W. (2003). Impaired recovery of Epstein-Barr virus (EBV)—specific CD8+ T lymphocytes after partially T-depleted allogeneic stem cell transplantation may identify patients at very high risk for progressive EBV reactivation and lymphoproliferative disease. Blood, 101(11), 4290-4297. doi:10.1182/blood-2002-10-3001DOI: 10.1182/blood-2002-10-3001
TAP-independent antigen presentation on MHC class I molecules: lessons from Epstein–Barr virus (Journal article)
Lautscham, G., Rickinson, A., & Blake, N. (2003). TAP-independent antigen presentation on MHC class I molecules: lessons from Epstein–Barr virus. Microbes and Infection, 5(4), 291-299. doi:10.1016/s1286-4579(03)00031-5DOI: 10.1016/s1286-4579(03)00031-5
Identification of a TAP-Independent, Immunoproteasome-Dependent CD8<sup>+</sup>T-Cell Epitope in Epstein-Barr Virus Latent Membrane Protein 2 (Journal article)
Lautscham, G., Haigh, T., Mayrhofer, S., Taylor, G., Croom-Carter, D., Leese, A., . . . Blake, N. (2003). Identification of a TAP-Independent, Immunoproteasome-Dependent CD8<sup>+</sup>T-Cell Epitope in Epstein-Barr Virus Latent Membrane Protein 2. Journal of Virology, 77(4), 2757-2761. doi:10.1128/jvi.77.4.2757-2761.2003DOI: 10.1128/jvi.77.4.2757-2761.2003
2002
Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits (Journal article)
Antoniou, A. N., Ford, S., Pilley, E. S., Blake, N., & Powis, S. J. (2002). Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits. Immunology, 106(2), 182-189. doi:10.1046/j.1365-2567.2002.01415.xDOI: 10.1046/j.1365-2567.2002.01415.x
B cells immortalized by a mini-Epstein-Barr virus encoding a foreign antigen efficiently reactivate specific cytotoxic T cells. (Journal article)
Moosmann, A., Khan, N., Cobbold, M., Zentz, C., Delecluse, H. -J., Hollweck, G., . . . Hammerschmidt, W. (2002). B cells immortalized by a mini-Epstein-Barr virus encoding a foreign antigen efficiently reactivate specific cytotoxic T cells.. Blood, 100(5), 1755-1764. Retrieved from http://www.bloodjournal.org/cgi/content/full/100/5/1755
Simultaneous induction of cytolytic T cell responses to adenovirus and CMVpp65 or EBNA3C proteins (Journal article)
Hamel, Y., Blake, N., Gabrielsson, S., Haigh, T., Jooss, K., Martinache, C., . . . Cavazzana-Calvo, M. (2002). Simultaneous induction of cytolytic T cell responses to adenovirus and CMVpp65 or EBNA3C proteins. Human Gene Therapy, 13(7), 855-866.
2001
Processing of a Multiple Membrane Spanning Epstein-Barr Virus Protein for Cd8+T Cell Recognition Reveals a Proteasome-Dependent, Transporter Associated with Antigen Processing–Independent Pathway (Journal article)
Lautscham, G., Mayrhofer, S., Taylor, G., Haigh, T., Leese, A., Rickinson, A., & Blake, N. (2001). Processing of a Multiple Membrane Spanning Epstein-Barr Virus Protein for Cd8+T Cell Recognition Reveals a Proteasome-Dependent, Transporter Associated with Antigen Processing–Independent Pathway. The Journal of Experimental Medicine, 194(8), 1053-1068. doi:10.1084/jem.194.8.1053DOI: 10.1084/jem.194.8.1053
Differential Immunogenicity of Epstein-Barr Virus Latent-Cycle Proteins for Human CD4<sup>+</sup>T-Helper 1 Responses (Journal article)
Leen, A., Meij, P., Redchenko, I., Middeldorp, J., Bloemena, E., Rickinson, A., & Blake, N. (2001). Differential Immunogenicity of Epstein-Barr Virus Latent-Cycle Proteins for Human CD4<sup>+</sup>T-Helper 1 Responses. Journal of Virology, 75(18), 8649-8659. doi:10.1128/jvi.75.18.8649-8659.2001DOI: 10.1128/jvi.75.18.8649-8659.2001
2000
The Importance of Exogenous Antigen in Priming the Human CD8+ T Cell Response: Lessons from the EBV Nuclear Antigen EBNA1 (Journal article)
Blake, N., Haigh, T., Shaka’a, G., Croom-Carter, D., & Rickinson, A. (2000). The Importance of Exogenous Antigen in Priming the Human CD8+ T Cell Response: Lessons from the EBV Nuclear Antigen EBNA1. The Journal of Immunology, 165(12), 7078-7087. doi:10.4049/jimmunol.165.12.7078DOI: 10.4049/jimmunol.165.12.7078
Novel intertypic recombinants of epstein-barr virus in the chinese population. (Journal article)
Midgley, R. S., Blake, N. W., Yao, Q. Y., Croom-Carter, D., Cheung, S. T., Leung, S. F., . . . Lee, S. P. (2000). Novel intertypic recombinants of epstein-barr virus in the chinese population.. Journal of virology, 74(3), 1544-1548. doi:10.1128/jvi.74.3.1544-1548.2000DOI: 10.1128/jvi.74.3.1544-1548.2000
1999
Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules (Journal article)
Moins-Teisserenc, H. T., Gadola, S. D., Cella, M., Dunbar, P. R., Exley, A., Blake, N., . . . Cerundolo, V. (1999). Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules. The Lancet, 354(9190), 1598-1603. doi:10.1016/s0140-6736(99)04206-3DOI: 10.1016/s0140-6736(99)04206-3
Inhibition of antigen presentation by the glycine/alanine repeat domain of the Epstein-Barr virus nuclear antigen 1 homologue is not essential for persistent infection by baboon and rhesus lymphocryptoviruses (Journal article)
Blake, N. W., Moghaddam, A., Roa, P., Kaur, A., Glickman, R., Cho, Y. -G., . . . Wang, F. (1999). Inhibition of antigen presentation by the glycine/alanine repeat domain of the Epstein-Barr virus nuclear antigen 1 homologue is not essential for persistent infection by baboon and rhesus lymphocryptoviruses. Journal of Virology, 73(9), 7381-7389.
1998
Antigen presenting phenotype of Hodgkin Reed-Sternberg cells: Analysis of the HLA class I processing pathway and the effects of interleukin 10 on Epstein-Barr virus cytotoxic T-cell recognition. (Journal article)
Lee, S. P., Constandinou, C. M., Thomas, W. A., Croom-Carter, D., Blake, N. W., Murray, P. G., . . . Rickinson, A. B. (1998). Antigen presenting phenotype of Hodgkin Reed-Sternberg cells: Analysis of the HLA class I processing pathway and the effects of interleukin 10 on Epstein-Barr virus cytotoxic T-cell recognition.. Blood, 92(3), 1020-1030.
1997
Human CD8 + T Cell Responses to EBV EBNA1: HLA Class I Presentation of the (Gly-Ala)–Containing Protein Requires Exogenous Processing (Journal article)
Blake, N., Lee, S., Redchenko, I., Thomas, W., Steven, N., Leese, A., . . . Rickinson, A. (1997). Human CD8 + T Cell Responses to EBV EBNA1: HLA Class I Presentation of the (Gly-Ala)–Containing Protein Requires Exogenous Processing. Immunity, 7(6), 791-802. doi:10.1016/s1074-7613(00)80397-0DOI: 10.1016/s1074-7613(00)80397-0
A case of primary immunodeficiency due to a defect of the major histocompatibility gene complex class I processing and presentation pathway (Journal article)
Teisserenc, H., Schmitt, W., Blake, N., Dunbar, R., Gadola, S., Gross, W. L., . . . Cerundolo, V. (1997). A case of primary immunodeficiency due to a defect of the major histocompatibility gene complex class I processing and presentation pathway. Immunology Letters, 57(1-3), 183-187. doi:10.1016/s0165-2478(97)00072-2DOI: 10.1016/s0165-2478(97)00072-2
1996
Similarity in genome organization between Molluscum contagiosum virus (MCV) and vaccinia virus (VV): identification of MCV homologues of the VV genes for protein kinase 2, structural protein VP8, RNA polymerase 35 kDa subunit and 3beta-hydroxysteroid dehydrogenase (Journal article)
Douglass, N. J., Blake, N. W., Cream, J. J., Soteriou, B. A., Zhang, H. Y., Theodoridou, A., & Archard, L. C. (1996). Similarity in genome organization between Molluscum contagiosum virus (MCV) and vaccinia virus (VV): identification of MCV homologues of the VV genes for protein kinase 2, structural protein VP8, RNA polymerase 35 kDa subunit and 3beta-hydroxysteroid dehydrogenase. Journal of General Virology, 77(12), 3113-3120. doi:10.1099/0022-1317-77-12-3113DOI: 10.1099/0022-1317-77-12-3113
Transporter (TAP)-independent processing of a multiple membrane-spanning protein, the Epstein-Barr virus latent membrane protein 2 (Journal article)
Lee, S. P., Thomas, W. A., Blake, N. W., & Rickinson, A. B. (1996). Transporter (TAP)-independent processing of a multiple membrane-spanning protein, the Epstein-Barr virus latent membrane protein 2. European Journal of Immunology, 26(8), 1875-1883. doi:10.1002/eji.1830260831DOI: 10.1002/eji.1830260831
A recombinant adenovirus expressing an Epstein -Barr virus (EBV) target antigen can selectively reactivate rare components of EBV cytotoxic T-lymphocyte memory in vitro. (Journal article)
Morgan, S. M., Wilkinson, G. W. G., Floettmann, E., Blake, N., & Rickinson, A. B. (1996). A recombinant adenovirus expressing an Epstein -Barr virus (EBV) target antigen can selectively reactivate rare components of EBV cytotoxic T-lymphocyte memory in vitro.. Journal of Virology, 70(4), 2394-2402.
1995
Vaccinia virus serpins B13R and B22R do not inhibit antigen presentation to class I-restricted cytotoxic T lymphocytes (Journal article)
Blake, N. W., Kettle, S., Law, K. M., Gould, K., Bastin, J., Townsend, A. R. M., & Smith, G. L. (1995). Vaccinia virus serpins B13R and B22R do not inhibit antigen presentation to class I-restricted cytotoxic T lymphocytes. Journal of General Virology, 76(9), 2393-2398. doi:10.1099/0022-1317-76-9-2393DOI: 10.1099/0022-1317-76-9-2393
A single amino acid substitution in the capsid protein VP1 of Coxsackievirus B3 (CVB3) alters plaque phenotype in Vero cells but not cardiovirulence in a mouse model (Journal article)
Zhang, H., Blake, N. W., Ouyang, X., Pandolfino, Y. A., Morgan-Capner, P., & Archard, L. C. (1995). A single amino acid substitution in the capsid protein VP1 of Coxsackievirus B3 (CVB3) alters plaque phenotype in Vero cells but not cardiovirulence in a mouse model. Archives of Virology, 140(5), 959-966. doi:10.1007/bf01314972DOI: 10.1007/bf01314972
Vaccinia virus serpins B13R (SPI-2) and B22R (SPI-1) encode Mr 38.5 and 40K, intracellular polypeptides that do not affect virus virulence in a murine intranasal model (Journal article)
Kettle, S., Blake, N. W., Law, K. M., & Smith, G. L. (1995). Vaccinia virus serpins B13R (SPI-2) and B22R (SPI-1) encode Mr 38.5 and 40K, intracellular polypeptides that do not affect virus virulence in a murine intranasal model. Virology, 206(1), 136-147. doi:10.1016/s0042-6822(95)80028-xDOI: 10.1016/s0042-6822(95)80028-x
1993
Attenuation of a reactivated cardiovirulent coxsackievirus B3: The 5′-nontranslated region does not contain major attenuation determinants (Journal article)
Zhang, H. Y., Yousef, G. E., Cunningham, L., Blake, N. W., Yang, X. O., Bayston, T. A., . . . Archard, L. C. (1993). Attenuation of a reactivated cardiovirulent coxsackievirus B3: The 5′-nontranslated region does not contain major attenuation determinants. Journal of Medical Virology, 41(2), 129-137. doi:10.1002/jmv.1890410208DOI: 10.1002/jmv.1890410208
1992
Molluscum contagiosum virus (Chapter)
Porter, C. D., Blake, N. W., Cream, J. J., & Archard, L. C. (1992). Molluscum contagiosum virus. In D. J. M. Wright, & L. C. Archard (Eds.), Molecular and Cell Biology of Sexually Transmitted Diseases (pp. 233-257). London: Chapman and Hall.
1991
Characterization of a molluscum contagiosum virus homologue of the vaccinia virus p37K major envelope antigen. (Journal article)
Blake, N. W., Porter, C. D., & Archard, L. C. (1991). Characterization of a molluscum contagiosum virus homologue of the vaccinia virus p37K major envelope antigen.. Journal of Virology, 65(7), 3583-3589.
1989
Molluscum contagiosum virus types in genital and non-genital lesions (Journal article)
PORTER, C. D., BLAKE, N. W., ARCHARD, L. C., MUHLEMANN, M. F., ROSEDALE, N., & CREAM, J. J. (1989). Molluscum contagiosum virus types in genital and non-genital lesions. British Journal of Dermatology, 120(1), 37-41. doi:10.1111/j.1365-2133.1989.tb07763.xDOI: 10.1111/j.1365-2133.1989.tb07763.x
